Smad3 (SMAD family member 3) - Rat Genome Database

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Gene: Smad3 (SMAD family member 3) Mus musculus
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Symbol: Smad3
Name: SMAD family member 3
RGD ID: 735647
MGI Page MGI
Description: Enables several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and promoter-specific chromatin binding activity. Involved in several processes, including JNK cascade; negative regulation of osteoblast proliferation; and positive regulation of chondrocyte differentiation. Acts upstream of or within several processes, including cell surface receptor protein serine/threonine kinase signaling pathway; embryonic morphogenesis; and regulation of DNA-templated transcription. Located in cytoplasm; nucleus; and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and limb. Used to study osteoarthritis. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 3; Lynch syndrome; and pancreatic cancer. Orthologous to human SMAD3 (SMAD family member 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AU022421; MAD homolog 3; mad3; Madh; Madh3; mMad3; mothers against decapentaplegic homolog 3; mothers against DPP homolog 3; Smad 3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39963,554,048 - 63,665,276 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl963,554,049 - 63,665,276 (-)EnsemblGRCm39 Ensembl
GRCm38963,646,766 - 63,757,994 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl963,646,767 - 63,757,994 (-)EnsemblGRCm38mm10GRCm38
MGSCv37963,494,574 - 63,605,801 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36963,444,773 - 63,556,000 (-)NCBIMGSCv36mm8
Celera960,869,117 - 60,980,879 (-)NCBICelera
Cytogenetic Map9CNCBI
cM Map934.22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-ephedrine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(R)-lipoic acid  (EXP)
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
1-O-oleoyl-sn-glycero-3-phosphocholine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-hydroxypropanoic acid  (ISO)
20-HETE  (ISO)
3,4-dihydroxybenzaldehyde  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-Methoxynobiletin  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (EXP)
4-nonylphenol  (ISO)
4-vinylcyclohexene dioxide  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
9-cis-retinoic acid  (EXP)
acetaldehyde  (ISO)
aconitic acid  (EXP,ISO)
acteoside  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-naphthoflavone  (ISO)
AM-251  (ISO)
Ammothamnine  (EXP)
amphetamine  (ISO)
andrographolide  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
asbestos  (ISO)
atrazine  (ISO)
azithromycin  (ISO)
azoxystrobin  (ISO)
bellidifolin  (EXP,ISO)
benazepril  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
benzophenone  (ISO)
betulin  (ISO)
betulinic acid  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP,ISO)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP,ISO)
candesartan  (ISO)
Candesartan cilexetil  (ISO)
cantharidin  (ISO)
carbamazepine  (ISO)
carbofuran  (ISO)
casticin  (ISO)
celastrol  (ISO)
ceruletide  (EXP)
CGP 52608  (ISO)
CGS-21680  (ISO)
chlorpyrifos  (ISO)
cholesterol  (EXP)
choline  (EXP)
chromium(6+)  (ISO)
chrysin  (EXP)
cisplatin  (EXP,ISO)
cocaine  (ISO)
coenzyme Q10  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP,ISO)
corosolic acid  (EXP)
corticosterone  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
cytochalasin D  (ISO)
D-glucose  (ISO)
deguelin  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP)
dimethyl sulfoxide  (ISO)
diminazene diaceturate  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (EXP,ISO)
disulfiram  (ISO)
doxorubicin  (EXP,ISO)
ebselen  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (ISO)
fenthion  (EXP)
ferulic acid  (ISO)
fipronil  (ISO)
fluoranthene  (EXP,ISO)
flutamide  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
galangin  (ISO)
gallic acid  (ISO)
Ganoderic acid A  (EXP)
genistein  (ISO)
geraniol  (ISO)
glucose  (ISO)
glyphosate  (ISO)
heptachlor  (ISO)
hexachlorobenzene  (EXP,ISO)
Honokiol  (EXP,ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
irbesartan  (ISO)
irinotecan  (ISO)
isoprenaline  (ISO)
isorhamnetin  (ISO)
ivermectin  (ISO)
L-methionine  (EXP)
lactucin  (EXP,ISO)
lead diacetate  (ISO)
leptomycin B  (EXP)
linoleic acid  (EXP)
lipoic acid  (EXP)
lipopolysaccharide  (EXP)
lithocholic acid  (EXP)
LY-2157299  (ISO)
lycopene  (ISO)
melphalan  (ISO)
menadione  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methoxychlor  (ISO)
Methylazoxymethanol acetate  (ISO)
methylmercury chloride  (EXP,ISO)
methylparaben  (ISO)
mirtazapine  (EXP)
monocrotaline  (ISO)
Muraglitazar  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
naringin  (ISO)
nickel atom  (EXP)
nickel dichloride  (EXP)
niclosamide  (EXP,ISO)
nicotinamide  (ISO)
nicotine  (EXP,ISO)
nitric oxide  (ISO)
nitrofen  (EXP)
Nonylphenol  (ISO)
ochratoxin A  (EXP,ISO)
oridonin  (ISO)
osthole  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
patulin  (ISO)
perfluorohexanesulfonic acid  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perindopril  (ISO)
phenylarsine oxide  (ISO)
phenylmercury acetate  (ISO)
phloroglucinol  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
Phyllanthin  (EXP)
picoxystrobin  (ISO)
picrotoxin  (ISO)
pinostrobin  (ISO)
pirinixic acid  (EXP)
platycodin D  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
quercetin  (EXP,ISO)
quercitrin  (ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
salvianolic acid B  (EXP,ISO)
SB 203580  (ISO)
SB 431542  (EXP,ISO)
SCH 23390  (ISO)
serpentine asbestos  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
simvastatin  (EXP,ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP)
sorafenib  (EXP)
sphingosine 1-phosphate  (ISO)
streptozocin  (EXP,ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP,ISO)
Tanshinone I  (ISO)
tauro-beta-muricholic acid  (EXP)
taurochenodeoxycholic acid  (EXP)
taurolithocholic acid  (EXP)
tauroursodeoxycholic acid  (EXP)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP,ISO)
thymoquinone  (ISO)
titanium dioxide  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tungsten  (EXP)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
vitamin D  (EXP,ISO)
vitamin E  (ISO)
zearalenone  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)
ziram  (ISO)
zoledronic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activin receptor signaling pathway  (IBA,ISO,NAS)
adrenal gland development  (IEA,ISO)
anatomical structure morphogenesis  (IBA)
apoptotic process  (IMP)
apoptotic signaling pathway  (ISO)
cell differentiation  (IBA)
cell population proliferation  (IGI)
cell-cell junction organization  (IEA,ISO)
cellular response to glucose stimulus  (IEA,ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to virus  (IDA)
developmental growth  (IGI)
embryonic cranial skeleton morphogenesis  (IGI)
embryonic foregut morphogenesis  (IGI)
embryonic pattern specification  (IGI)
endoderm development  (IGI)
extrinsic apoptotic signaling pathway  (IEA,ISO)
gastrulation  (IGI)
heart looping  (IGI)
immune response  (IEA,ISO)
immune system development  (IGI)
in utero embryonic development  (IGI)
JNK cascade  (IMP)
lens fiber cell differentiation  (IMP)
liver development  (IGI)
MAPK cascade  (IMP)
mesoderm formation  (IMP)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of cardiac muscle hypertrophy in response to stress  (IEA,ISO)
negative regulation of cell growth  (IEA,ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cytosolic calcium ion concentration  (IEA,ISO)
negative regulation of fat cell differentiation  (IEA,ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of inflammatory response  (IMP)
negative regulation of lung blood pressure  (IEA,ISO)
negative regulation of miRNA transcription  (IEA,ISO)
negative regulation of ossification  (ISO)
negative regulation of osteoblast differentiation  (IGI)
negative regulation of osteoblast proliferation  (IMP)
negative regulation of protein catabolic process  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IDA,ISO)
negative regulation of wound healing  (IMP)
nodal signaling pathway  (IEA,ISO)
osteoblast development  (IGI)
osteoblast differentiation  (IMP)
paraxial mesoderm morphogenesis  (IMP)
pericardium development  (IGI)
positive regulation of alkaline phosphatase activity  (ISO)
positive regulation of bone mineralization  (IEA,ISO)
positive regulation of canonical Wnt signaling pathway  (IEA,ISO)
positive regulation of cell migration  (IEA,ISO)
positive regulation of chondrocyte differentiation  (IMP)
positive regulation of cysteine-type endopeptidase activity  (ISO)
positive regulation of DNA-templated transcription  (IDA,ISO)
positive regulation of epithelial to mesenchymal transition  (IEA,ISO)
positive regulation of extracellular matrix assembly  (IEA,ISO)
positive regulation of focal adhesion assembly  (IEA,ISO)
positive regulation of gene expression  (ISO)
positive regulation of interleukin-1 beta production  (IEA,ISO)
positive regulation of miRNA transcription  (IEA,ISO)
positive regulation of nitric oxide biosynthetic process  (IEA,ISO)
positive regulation of positive chemotaxis  (IEA,ISO)
positive regulation of SMAD protein signal transduction  (ISO)
positive regulation of stress fiber assembly  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IBA,IDA,IGI,IMP,ISO)
positive regulation of transforming growth factor beta3 production  (IEA,ISO)
protein stabilization  (IEA,ISO)
regulation of DNA-templated transcription  (ISO,NAS)
regulation of epithelial cell proliferation  (IMP)
regulation of immune response  (IMP)
regulation of mitochondrial membrane potential  (ISO)
regulation of striated muscle tissue development  (IDA)
regulation of transcription by RNA polymerase II  (ISO)
regulation of transforming growth factor beta receptor signaling pathway  (IDA)
regulation of transforming growth factor beta2 production  (IEA,ISO)
release of cytochrome c from mitochondria  (ISO)
response to angiotensin  (IEA,ISO)
response to hypoxia  (IEA,ISO)
response to transforming growth factor beta  (IGI)
signal transduction involved in regulation of gene expression  (IEA,ISO)
skeletal system development  (IGI)
SMAD protein signal transduction  (IBA,IGI,ISO)
somitogenesis  (IMP)
T cell activation  (IMP)
thyroid gland development  (IGI)
transdifferentiation  (IEA,ISO)
transforming growth factor beta receptor signaling pathway  (IBA,IDA,IMP,ISO,NAS)
ureteric bud development  (IEP)

Cellular Component

Molecular Function
beta-catenin binding  (IEA,ISO)
bHLH transcription factor binding  (IEA,ISO)
chromatin binding  (IDA)
chromatin DNA binding  (IDA)
cis-regulatory region sequence-specific DNA binding  (ISO,ISS)
co-SMAD binding  (IEA,ISO)
collagen binding  (IPI)
DEAD/H-box RNA helicase binding  (IEA,ISO)
DNA binding  (IDA,ISO)
DNA-binding transcription activator activity, RNA polymerase II-specific  (IPI,ISO)
DNA-binding transcription factor activity  (IDA,ISO)
DNA-binding transcription factor activity, RNA polymerase II-specific  (IBA,ISO)
DNA-binding transcription factor binding  (ISO)
DNA-binding transcription repressor activity  (IEA,ISO)
double-stranded DNA binding  (IDA)
enzyme binding  (ISO)
I-SMAD binding  (IBA)
identical protein binding  (IPI,ISO)
nuclear glucocorticoid receptor binding  (IEA,ISO)
nuclear mineralocorticoid receptor binding  (IEA,ISO)
nuclear receptor binding  (ISO)
phosphatase binding  (IEA,ISO)
promoter-specific chromatin binding  (IDA)
protein binding  (IPI)
protein homodimerization activity  (IEA,ISO)
protein kinase binding  (IEA,ISO)
R-SMAD binding  (IEA,ISO)
RNA polymerase II cis-regulatory region sequence-specific DNA binding  (IBA,ISO)
RNA polymerase II transcription regulatory region sequence-specific DNA binding  (IDA,ISO)
RNA polymerase II-specific DNA-binding transcription factor binding  (IPI,ISO)
sequence-specific DNA binding  (ISO)
sterol response element binding  (IEA,ISO)
transcription cis-regulatory region binding  (ISO)
transcription coactivator binding  (IEA,ISO)
transcription corepressor binding  (IEA,ISO)
transcription factor binding  (ISO)
transforming growth factor beta receptor binding  (IEA,ISO)
ubiquitin binding  (IEA,ISO)
ubiquitin protein ligase binding  (IEA,ISO)
zinc ion binding  (IEA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal anterior definitive endoderm morphology  (IAGP)
abnormal articular cartilage morphology  (IAGP)
abnormal B cell proliferation  (IAGP)
abnormal carpal bone morphology  (IAGP)
abnormal cartilage morphology  (IAGP)
abnormal CD4-positive T cell differentiation  (IAGP)
abnormal cell morphology  (IAGP)
abnormal cell physiology  (IAGP)
abnormal cell proliferation  (IAGP)
abnormal chondrocyte morphology  (IAGP)
abnormal circulating interleukin-6 level  (IAGP)
abnormal colon morphology  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal cumulus expansion  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal developmental patterning  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal endoderm development  (IAGP)
abnormal epiphyseal plate morphology  (IAGP)
abnormal fertility/fecundity  (IAGP)
abnormal foregut morphology  (IAGP)
abnormal forelimb morphology  (IAGP)
abnormal gastrulation  (IAGP)
abnormal heart development  (IAGP)
abnormal heart looping  (IAGP)
abnormal hepatic cord morphology  (IAGP)
abnormal hepatoblast migration  (IAGP)
abnormal hepatocyte physiology  (IAGP)
abnormal immune system morphology  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal joint morphology  (IAGP)
abnormal keratinocyte physiology  (IAGP)
abnormal kidney epithelium morphology  (IAGP)
abnormal leukocyte physiology  (IAGP)
abnormal liver morphology  (IAGP)
abnormal locomotor behavior  (IAGP)
abnormal Meckel's cartilage morphology  (IAGP)
abnormal mesangial matrix morphology  (IAGP)
abnormal mesendoderm development  (IAGP)
abnormal ovarian follicle morphology  (IAGP)
abnormal ovarian folliculogenesis  (IAGP)
abnormal pericardial cavity morphology  (IAGP)
abnormal physiological response to xenobiotic  (IAGP)
abnormal posture  (IAGP)
abnormal prechordal plate morphology  (IAGP)
abnormal primitive streak formation  (IAGP)
abnormal rectum morphology  (IAGP)
abnormal renal glomerulus basement membrane thickness  (IAGP)
abnormal rib morphology  (IAGP)
abnormal skeleton physiology  (IAGP)
abnormal somite development  (IAGP)
abnormal sternum morphology  (IAGP)
abnormal synovial joint capsule morphology  (IAGP)
abnormal T cell activation  (IAGP)
abnormal T cell physiology  (IAGP)
abnormal T cell proliferation  (IAGP)
abnormal talus morphology  (IAGP)
abnormal tarsal bone morphology  (IAGP)
abnormal thoracic cage morphology  (IAGP)
abnormal thymus involution  (IAGP)
abnormal vascular wound healing  (IAGP)
absent foregut  (IAGP)
calcified joint  (IAGP)
colitis  (IAGP)
colon polyps  (IAGP)
cyclopia  (IAGP)
decreased apoptosis  (IAGP)
decreased B cell apoptosis  (IAGP)
decreased blood urea nitrogen level  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral density  (IAGP)
decreased circulating alkaline phosphatase level  (IEA)
decreased circulating creatinine level  (IAGP)
decreased hepatocyte proliferation  (IAGP)
decreased interleukin-6 secretion  (IAGP)
decreased kidney weight  (IAGP)
decreased litter size  (IAGP)
decreased lymphocyte cell number  (IEA)
decreased oocyte number  (IAGP)
decreased primary ovarian follicle number  (IAGP)
decreased renal tubule apoptosis  (IAGP)
decreased secondary ovarian follicle number  (IAGP)
decreased susceptibility to injury  (IAGP)
decreased susceptibility to kidney reperfusion injury  (IAGP)
decreased tertiary ovarian follicle number  (IAGP)
delayed hepatic development  (IAGP)
dilated liver sinusoidal space  (IAGP)
distended abdomen  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
enhanced wound healing  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged mesenteric lymph nodes  (IAGP)
extramedullary hematopoiesis  (IAGP)
fused somites  (IAGP)
holoprosencephaly  (IAGP)
impaired neutrophil chemotaxis  (IAGP)
impaired ovarian folliculogenesis  (IAGP)
increased adenoma incidence  (IAGP)
increased adrenal gland tumor incidence  (IAGP)
increased atretic ovarian follicle number  (IAGP)
increased body weight  (IAGP)
increased circulating creatinine level  (IAGP)
increased circulating follicle stimulating hormone level  (IAGP)
increased circulating luteinizing hormone level  (IAGP)
increased colon adenocarcinoma incidence  (IAGP)
increased erythrocyte cell number  (IAGP)
increased fetal size  (IAGP)
increased inflammatory response  (IAGP)
increased intestinal adenocarcinoma incidence  (IAGP)
increased leukocyte cell number  (IAGP)
increased metastatic potential  (IAGP)
increased monocyte cell number  (IAGP)
increased neutrophil cell number  (IAGP)
increased ovary tumor incidence  (IAGP)
increased physiological sensitivity to xenobiotic  (IAGP)
increased primordial ovarian follicle number  (IAGP)
increased Sertoli cell number  (IAGP)
increased susceptibility to kidney reperfusion injury  (IAGP)
increased width of hypertrophic chondrocyte zone  (IAGP)
intestinal obstruction  (IAGP)
kyphoscoliosis  (IAGP)
kyphosis  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lethargy  (IAGP)
liver hypoplasia  (IAGP)
osteoarthritis  (IAGP)
pancreas inflammation  (IAGP)
premature death  (IAGP)
premature ovarian failure  (IAGP)
preweaning lethality, complete penetrance  (IEA)
rectal prolapse  (IAGP)
reduced female fertility  (IAGP)
renal interstitial fibrosis  (IAGP)
renal tubular necrosis  (IAGP)
rostral body truncation  (IAGP)
ruffled hair  (IAGP)
small intestinal inflammation  (IAGP)
small liver  (IAGP)
small spleen  (IAGP)
small thyroid gland  (IAGP)
spleen hypoplasia  (IAGP)
stomach inflammation  (IAGP)
thymus hypoplasia  (IAGP)
tubulointerstitial nephritis  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Cardioprotective role of growth/differentiation factor 1 in post-infarction left ventricular remodelling and dysfunction. Bao MW, etal., J Pathol. 2015 Jul;236(3):360-72. doi: 10.1002/path.4523. Epub 2015 Mar 30.
2. Ovarian follicle populations of the rat express TGF-beta signalling pathways. Drummond AE, etal., Mol Cell Endocrinol. 2003 Apr 28;202(1-2):53-7.
3. Bone marrow derived-mesenchymal stem cells downregulate IL17A dependent IL6/STAT3 signaling pathway in CCl4-induced rat liver fibrosis. Farouk S, etal., PLoS One. 2018 Oct 22;13(10):e0206130. doi: 10.1371/journal.pone.0206130. eCollection 2018.
4. Tumor suppression effects of bilberry extracts and enzymatically modified isoquercitrin in early preneoplastic liver cell lesions induced by piperonyl butoxide promotion in a two-stage rat hepatocarcinogenesis model. Hara S, etal., Exp Toxicol Pathol. 2014 Aug;66(5-6):225-34. doi: 10.1016/j.etp.2014.02.002. Epub 2014 Mar 26.
5. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Jones S, etal., Science. 2008 Sep 26;321(5897):1801-6. Epub 2008 Sep 4.
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