Smad3 Mouse (-)-ephedrine increases expression ISO Smad3 (Rattus norvegicus) 6480464 Ephedrine results in increased expression of SMAD3 mRNA and Ephedrine results in increased expression of SMAD3 protein CTD PMID:32729338 Smad3 Mouse (-)-epigallocatechin 3-gallate multiple interactions ISO SMAD3 (Homo sapiens) 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SMAD3 mRNA CTD PMID:22079256 Smad3 Mouse (-)-epigallocatechin 3-gallate decreases expression EXP 6480464 epigallocatechin gallate results in decreased expression of SMAD3 protein CTD PMID:34600025 Smad3 Mouse (-)-epigallocatechin 3-gallate increases expression EXP 6480464 epigallocatechin gallate results in increased expression of SMAD3 protein CTD PMID:35863485 Smad3 Mouse (R)-lipoic acid multiple interactions EXP 6480464 Thioctic Acid inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD3 protein] CTD PMID:35187969 Smad3 Mouse (S)-nicotine multiple interactions EXP 6480464 [Nicotine co-treated with 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 Smad3 Mouse (S)-nicotine multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 Nicotine results in increased expression of and results in increased phosphorylation of SMAD3 protein CTD PMID:22691361 Smad3 Mouse (S)-nicotine decreases expression ISO Smad3 (Rattus norvegicus) 6480464 Nicotine results in decreased expression of SMAD3 mRNA CTD PMID:29660438 Smad3 Mouse 1,2-dimethylhydrazine increases expression EXP 6480464 1 and 2-Dimethylhydrazine results in increased expression of SMAD3 mRNA CTD PMID:22206623 Smad3 Mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine decreases expression EXP 6480464 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 Smad3 Mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactions EXP 6480464 [Caffeine co-treated with 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 Smad3 Mouse 1-O-oleoyl-sn-glycero-3-phosphocholine decreases abundance EXP 6480464 SMAD3 protein results in decreased abundance of 1-oleoyl lysophosphatidylcholine CTD PMID:23034213 Smad3 Mouse 17alpha-ethynylestradiol decreases expression EXP 6480464 Ethinyl Estradiol results in decreased expression of SMAD3 mRNA CTD PMID:17942748 Smad3 Mouse 17alpha-ethynylestradiol multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of SMAD3 mRNA CTD PMID:17942748 Smad3 Mouse 17beta-estradiol decreases expression ISO SMAD3 (Homo sapiens) 6480464 Estradiol results in decreased expression of SMAD3 mRNA CTD PMID:19167446 and PMID:24758408 Smad3 Mouse 17beta-estradiol increases expression ISO SMAD3 (Homo sapiens) 6480464 Estradiol results in increased expression of SMAD3 protein CTD PMID:33181973 Smad3 Mouse 17beta-estradiol decreases phosphorylation ISO SMAD3 (Homo sapiens) 6480464 Estradiol results in decreased phosphorylation of SMAD3 protein CTD PMID:24308608 and PMID:26407941 Smad3 Mouse 17beta-estradiol affects expression ISO SMAD3 (Homo sapiens) 6480464 Estradiol affects the expression of SMAD3 mRNA CTD PMID:14699072 and PMID:22574217 Smad3 Mouse 17beta-estradiol multiple interactions ISO SMAD3 (Homo sapiens) 6480464 [Estradiol co-treated with Progesterone] results in decreased expression of SMAD3 mRNA more ... CTD PMID:20660070 more ... Smad3 Mouse 17beta-hydroxy-5alpha-androstan-3-one increases expression ISO SMAD3 (Homo sapiens) 6480464 Dihydrotestosterone results in increased expression of SMAD3 mRNA CTD PMID:16597033 Smad3 Mouse 2,3',4,4',5-Pentachlorobiphenyl affects expression EXP 6480464 2 more ... CTD PMID:31388691 Smad3 Mouse 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of SMAD3 mRNA CTD PMID:24058054 Smad3 Mouse 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Smad3 (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of SMAD3 mRNA CTD PMID:33387578 Smad3 Mouse 2,3,7,8-tetrachlorodibenzodioxine affects phosphorylation ISO SMAD3 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin affects the phosphorylation of SMAD3 protein CTD PMID:31887333 Smad3 Mouse 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO SMAD3 (Homo sapiens) 6480464 AHR protein affects the reaction [Tetrachlorodibenzodioxin affects the phosphorylation of SMAD3 protein] CTD PMID:31887333 Smad3 Mouse 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of SMAD3 mRNA CTD PMID:21570461 Smad3 Mouse 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of SMAD3 mRNA and [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of SMAD3 mRNA CTD PMID:17942748 and PMID:25975270 Smad3 Mouse 2-acetamidofluorene multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD3 protein and IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD3 protein] CTD PMID:15368444 Smad3 Mouse 2-amino-2-deoxy-D-galactopyranose increases phosphorylation ISO Smad3 (Rattus norvegicus) 6480464 Galactosamine results in increased phosphorylation of SMAD3 protein CTD PMID:27876602 Smad3 Mouse 2-amino-2-deoxy-D-galactopyranose multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 Genistein inhibits the reaction [Galactosamine results in increased phosphorylation of SMAD3 protein] CTD PMID:27876602 Smad3 Mouse 2-hydroxypropanoic acid increases expression ISO SMAD3 (Homo sapiens) 6480464 Lactic Acid results in increased expression of SMAD3 mRNA CTD PMID:30851411 Smad3 Mouse 20-HETE multiple interactions ISO SMAD3 (Homo sapiens) 6480464 20-hydroxyeicosa-5(Z) more ... CTD PMID:36368619 Smad3 Mouse 20-HETE increases phosphorylation ISO SMAD3 (Homo sapiens) 6480464 20-hydroxy-5 more ... CTD PMID:36368619 Smad3 Mouse 3,4-dihydroxybenzaldehyde multiple interactions ISO SMAD3 (Homo sapiens) 6480464 protocatechualdehyde inhibits the reaction [Glucose results in increased phosphorylation of and affects the localization of SMAD3 protein] and protocatechualdehyde inhibits the reaction [S100B protein results in increased phosphorylation of and affects the localization of SMAD3 protein] CTD PMID:17597607 Smad3 Mouse 3,4-methylenedioxymethamphetamine increases expression EXP 6480464 N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of SMAD3 mRNA CTD PMID:20188158 Smad3 Mouse 3-Methoxynobiletin affects phosphorylation ISO SMAD3 (Homo sapiens) 6480464 3 more ... CTD PMID:29470423 Smad3 Mouse 4,4'-sulfonyldiphenol increases expression ISO SMAD3 (Homo sapiens) 6480464 bisphenol S results in increased expression of SMAD3 protein CTD PMID:33181973 Smad3 Mouse 4-hydroxyphenyl retinamide increases expression EXP 6480464 Fenretinide results in increased expression of SMAD3 mRNA CTD PMID:28973697 Smad3 Mouse 4-nonylphenol multiple interactions ISO SMAD3 (Homo sapiens) 6480464 fulvestrant inhibits the reaction [4-nonylphenol results in decreased phosphorylation of SMAD3 protein] CTD PMID:24308608 Smad3 Mouse 4-nonylphenol decreases phosphorylation ISO SMAD3 (Homo sapiens) 6480464 4-nonylphenol results in decreased phosphorylation of SMAD3 protein CTD PMID:24308608 Smad3 Mouse 4-vinylcyclohexene dioxide affects expression EXP 6480464 4-vinyl-1-cyclohexene dioxide affects the expression of SMAD3 mRNA CTD PMID:20829426 Smad3 Mouse 5-aza-2'-deoxycytidine multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 Decitabine inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:24211420 Smad3 Mouse 5-aza-2'-deoxycytidine increases expression EXP 6480464 Decitabine results in increased expression of SMAD3 mRNA CTD PMID:27915011 Smad3 Mouse 6-propyl-2-thiouracil multiple interactions ISO SMAD3 (Homo sapiens) 6480464 Propylthiouracil inhibits the reaction [Monocrotaline results in increased expression of SMAD3 protein] CTD PMID:36942326 Smad3 Mouse 9-cis-retinoic acid multiple interactions EXP 6480464 [T0901317 co-treated with Alitretinoin] results in increased expression of SMAD3 protein CTD PMID:17194744 Smad3 Mouse acetaldehyde multiple interactions ISO SMAD3 (Homo sapiens) 6480464 SMAD3 protein promotes the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA] CTD PMID:16025520 Smad3 Mouse acetaldehyde increases phosphorylation ISO SMAD3 (Homo sapiens) 6480464 Acetaldehyde results in increased phosphorylation of SMAD3 protein CTD PMID:16025520 Smad3 Mouse aconitic acid multiple interactions ISO SMAD3 (Homo sapiens) 6480464 [Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Sugars co-treated with TGFB1 protein] results in increased phosphorylation of SMAD3 protein] more ... CTD PMID:38282657 Smad3 Mouse aconitic acid multiple interactions EXP 6480464 [Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased phosphorylation of SMAD3 protein] CTD PMID:38282657 Smad3 Mouse acteoside increases phosphorylation ISO SMAD3 (Homo sapiens) 6480464 acteoside results in increased phosphorylation of SMAD3 protein CTD PMID:17634406 Smad3 Mouse aflatoxin B1 increases expression ISO SMAD3 (Homo sapiens) 6480464 Aflatoxin B1 results in increased expression of SMAD3 mRNA CTD PMID:21641981 and PMID:22100608 Smad3 Mouse aldehydo-D-glucose multiple interactions ISO SMAD3 (Homo sapiens) 6480464 4-(4-((5-(4 more ... CTD PMID:17597607 and PMID:26045780 Smad3 Mouse aldehydo-D-glucose increases phosphorylation ISO SMAD3 (Homo sapiens) 6480464 Glucose results in increased phosphorylation of SMAD3 protein CTD PMID:26045780 Smad3 Mouse all-trans-retinoic acid multiple interactions ISO SMAD3 (Homo sapiens) 6480464 SMAD3 protein inhibits the reaction [Tretinoin results in decreased expression of FBN2] more ... CTD PMID:17098229 and PMID:24374174 Smad3 Mouse all-trans-retinoic acid increases expression ISO SMAD3 (Homo sapiens) 6480464 Tretinoin results in increased expression of SMAD3 mRNA CTD PMID:16012519 more ... Smad3 Mouse all-trans-retinoic acid decreases phosphorylation ISO SMAD3 (Homo sapiens) 6480464 Tretinoin results in decreased phosphorylation of SMAD3 protein CTD PMID:24374174 Smad3 Mouse all-trans-retinoic acid decreases phosphorylation EXP 6480464 Tretinoin results in decreased phosphorylation of SMAD3 protein CTD PMID:16410076 Smad3 Mouse all-trans-retinoic acid increases phosphorylation ISO SMAD3 (Homo sapiens) 6480464 Tretinoin results in increased phosphorylation of SMAD3 protein CTD PMID:17098229 Smad3 Mouse alpha-naphthoflavone multiple interactions ISO SMAD3 (Homo sapiens) 6480464 alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of SMAD3 protein] CTD PMID:27519288 Smad3 Mouse AM-251 multiple interactions ISO SMAD3 (Homo sapiens) 6480464 AM 251 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:27936102 Smad3 Mouse Ammothamnine multiple interactions EXP 6480464 oxymatrine inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 mRNA] CTD PMID:18395914 Smad3 Mouse Ammothamnine decreases expression EXP 6480464 oxymatrine results in decreased expression of SMAD3 protein CTD PMID:35785413 Smad3 Mouse amphetamine decreases expression ISO Smad3 (Rattus norvegicus) 6480464 Amphetamine results in decreased expression of SMAD3 mRNA CTD PMID:30779732 Smad3 Mouse andrographolide multiple interactions EXP 6480464 andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:31706003 Smad3 Mouse anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 pyrazolanthrone inhibits the reaction [Diethylnitrosamine affects the phosphorylation of SMAD3 protein] CTD PMID:19418558 Smad3 Mouse anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions EXP 6480464 [pyrazolanthrone co-treated with 6 more ... CTD PMID:31447676 Smad3 Mouse antirheumatic drug decreases expression ISO SMAD3 (Homo sapiens) 6480464 Antirheumatic Agents results in decreased expression of SMAD3 mRNA CTD PMID:24449571 Smad3 Mouse aripiprazole multiple interactions ISO SMAD3 (Homo sapiens) 6480464 [Aripiprazole co-treated with Ozone] results in increased expression of SMAD3 mRNA CTD PMID:31476115 Smad3 Mouse aristolochic acid A increases expression EXP 6480464 aristolochic acid I results in increased expression of SMAD3 mRNA and aristolochic acid I results in increased expression of SMAD3 protein CTD PMID:26108275 Smad3 Mouse arsane multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 Grape Seed Extract inhibits the reaction [Arsenic results in increased expression of SMAD3 protein modified form] CTD PMID:24348802 Smad3 Mouse arsane increases expression ISO Smad3 (Rattus norvegicus) 6480464 Arsenic results in increased expression of SMAD3 protein modified form CTD PMID:24348802 Smad3 Mouse arsenic atom multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 Grape Seed Extract inhibits the reaction [Arsenic results in increased expression of SMAD3 protein modified form] CTD PMID:24348802 Smad3 Mouse arsenic atom increases expression ISO Smad3 (Rattus norvegicus) 6480464 Arsenic results in increased expression of SMAD3 protein modified form CTD PMID:24348802 Smad3 Mouse arsenite(3-) multiple interactions EXP 6480464 arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein] more ... CTD PMID:25145660 and PMID:26354774 Smad3 Mouse arsenous acid multiple interactions ISO SMAD3 (Homo sapiens) 6480464 [Arsenic Trioxide results in increased expression of MIR491 mRNA] which results in decreased expression of SMAD3 mRNA more ... CTD PMID:21649584 more ... Smad3 Mouse arsenous acid decreases expression ISO SMAD3 (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of SMAD3 mRNA and Arsenic Trioxide results in decreased expression of SMAD3 protein CTD PMID:25196641 more ... Smad3 Mouse arsenous acid decreases response to substance ISO SMAD3 (Homo sapiens) 6480464 SMAD3 protein results in decreased susceptibility to Arsenic Trioxide CTD PMID:20707922 Smad3 Mouse arsenous acid increases expression ISO SMAD3 (Homo sapiens) 6480464 Arsenic Trioxide results in increased expression of SMAD3 mRNA CTD PMID:29633893 Smad3 Mouse asbestos multiple interactions ISO SMAD3 (Homo sapiens) 6480464 [Asbestos more ... CTD PMID:25358858 Smad3 Mouse atrazine affects methylation ISO Smad3 (Rattus norvegicus) 6480464 Atrazine affects the methylation of SMAD3 gene CTD PMID:35440735 Smad3 Mouse azithromycin multiple interactions ISO SMAD3 (Homo sapiens) 6480464 Azithromycin inhibits the reaction [Transforming Growth Factor beta1 results in increased phosphorylation of SMAD3 protein] CTD PMID:36581200 Smad3 Mouse azoxystrobin decreases expression ISO SMAD3 (Homo sapiens) 6480464 azoxystrobin results in decreased expression of SMAD3 mRNA CTD PMID:33512557 Smad3 Mouse bellidifolin multiple interactions ISO SMAD3 (Homo sapiens) 6480464 bellidifolin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:35586685 Smad3 Mouse bellidifolin multiple interactions EXP 6480464 bellidifolin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:33995055 Smad3 Mouse bellidifolin multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 bellidifolin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:33995055 Smad3 Mouse benazepril affects expression ISO Smad3 (Rattus norvegicus) 6480464 benazepril affects the expression of SMAD3 mRNA and benazepril affects the expression of SMAD3 protein CTD PMID:16635409 Smad3 Mouse benazepril multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 [benazepril co-treated with candesartan] results in decreased expression of SMAD3 protein more ... CTD PMID:16635409 and PMID:19487956 Smad3 Mouse benzene increases expression ISO SMAD3 (Homo sapiens) 6480464 Benzene results in increased expression of SMAD3 mRNA CTD PMID:19162166 Smad3 Mouse benzo[a]pyrene affects methylation ISO SMAD3 (Homo sapiens) 6480464 Benzo(a)pyrene affects the methylation of SMAD3 promoter CTD PMID:27901495 and PMID:30157460 Smad3 Mouse benzo[a]pyrene multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 [Benzo(a)pyrene co-treated with 1 more ... CTD PMID:18711122 Smad3 Mouse benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of SMAD3 mRNA CTD PMID:22228805 Smad3 Mouse benzo[a]pyrene diol epoxide I decreases expression ISO SMAD3 (Homo sapiens) 6480464 7 more ... CTD PMID:19150397 and PMID:20018196 Smad3 Mouse benzo[b]fluoranthene multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 [Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of SMAD3 mRNA CTD PMID:18711122 Smad3 Mouse benzo[e]pyrene increases methylation ISO SMAD3 (Homo sapiens) 6480464 benzo(e)pyrene results in increased methylation of SMAD3 intron CTD PMID:30157460 Smad3 Mouse benzophenone decreases phosphorylation ISO SMAD3 (Homo sapiens) 6480464 benzophenone results in decreased phosphorylation of SMAD3 protein CTD PMID:24308608 Smad3 Mouse benzophenone multiple interactions ISO SMAD3 (Homo sapiens) 6480464 fulvestrant inhibits the reaction [benzophenone results in decreased phosphorylation of SMAD3 protein] CTD PMID:24308608 Smad3 Mouse betulin multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 betulin inhibits the reaction [Ethanol results in increased phosphorylation of SMAD3 protein] CTD PMID:21172400 Smad3 Mouse betulinic acid multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 Betulinic Acid inhibits the reaction [Ethanol results in increased phosphorylation of SMAD3 protein] CTD PMID:21172400 Smad3 Mouse bis(2-chloroethyl) sulfide decreases expression EXP 6480464 Mustard Gas results in decreased expression of SMAD3 mRNA CTD PMID:15674843 Smad3 Mouse bisphenol A decreases phosphorylation ISO SMAD3 (Homo sapiens) 6480464 bisphenol A results in decreased phosphorylation of SMAD3 protein CTD PMID:24308608 and PMID:26407941 Smad3 Mouse bisphenol A increases expression ISO SMAD3 (Homo sapiens) 6480464 bisphenol A results in increased expression of SMAD3 protein CTD PMID:33181973 Smad3 Mouse bisphenol A decreases expression ISO SMAD3 (Homo sapiens) 6480464 bisphenol A analog results in decreased expression of SMAD3 mRNA CTD PMID:32387340 Smad3 Mouse bisphenol A decreases expression ISO Smad3 (Rattus norvegicus) 6480464 bisphenol A results in decreased expression of SMAD3 mRNA CTD PMID:30816183 and PMID:34097993 Smad3 Mouse bisphenol A increases methylation ISO SMAD3 (Homo sapiens) 6480464 bisphenol A results in increased methylation of SMAD3 promoter CTD PMID:27271280 Smad3 Mouse bisphenol A affects methylation EXP 6480464 bisphenol A affects the methylation of SMAD3 promoter CTD PMID:27334623 Smad3 Mouse bisphenol A multiple interactions ISO SMAD3 (Homo sapiens) 6480464 [bisphenol A co-treated with Fulvestrant] affects the methylation of SMAD3 gene more ... CTD PMID:24308608 more ... Smad3 Mouse bleomycin A2 increases phosphorylation EXP 6480464 Bleomycin results in increased phosphorylation of SMAD3 protein CTD PMID:27704718 more ... Smad3 Mouse bleomycin A2 increases expression ISO Smad3 (Rattus norvegicus) 6480464 Bleomycin results in increased expression of SMAD3 mRNA CTD PMID:26093215 Smad3 Mouse bleomycin A2 multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 Phytochemicals inhibits the reaction [Bleomycin results in increased expression of SMAD3 mRNA] CTD PMID:26093215 Smad3 Mouse bleomycin A2 multiple interactions EXP 6480464 2-((dimethylamino)methyl)-9-hydroxythieno(2 more ... CTD PMID:27704718 more ... Smad3 Mouse butan-1-ol multiple interactions ISO SMAD3 (Homo sapiens) 6480464 [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of SMAD3 mRNA CTD PMID:29432896 Smad3 Mouse butanal decreases expression ISO SMAD3 (Homo sapiens) 6480464 butyraldehyde results in decreased expression of SMAD3 mRNA CTD PMID:26079696 Smad3 Mouse cadmium atom decreases expression ISO SMAD3 (Homo sapiens) 6480464 Cadmium results in decreased expression of SMAD3 mRNA CTD PMID:33559965 Smad3 Mouse cadmium atom multiple interactions ISO SMAD3 (Homo sapiens) 6480464 [Acetylcysteine co-treated with Cadmium] results in decreased expression of SMAD3 mRNA more ... CTD PMID:29408318 more ... Smad3 Mouse cadmium dichloride multiple interactions ISO SMAD3 (Homo sapiens) 6480464 [Acetylcysteine co-treated with Cadmium Chloride co-treated with sodium arsenite] results in decreased expression of SMAD3 mRNA more ... CTD PMID:29408318 more ... Smad3 Mouse cadmium dichloride decreases expression ISO SMAD3 (Homo sapiens) 6480464 Cadmium Chloride results in decreased expression of SMAD3 mRNA CTD PMID:38568856 Smad3 Mouse caffeine multiple interactions EXP 6480464 [Caffeine co-treated with 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 Smad3 Mouse caffeine decreases expression ISO Smad3 (Rattus norvegicus) 6480464 Caffeine results in decreased expression of SMAD3 mRNA CTD PMID:32663519 Smad3 Mouse candesartan multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 [benazepril co-treated with candesartan] results in decreased expression of SMAD3 protein CTD PMID:19487956 Smad3 Mouse Candesartan cilexetil multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 candesartan cilexetil inhibits the reaction [sodium arsenite results in increased expression of SMAD3 protein modified form] CTD PMID:27889505 Smad3 Mouse cantharidin multiple interactions ISO SMAD3 (Homo sapiens) 6480464 Cantharidin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:31652400 Smad3 Mouse carbamazepine affects expression ISO SMAD3 (Homo sapiens) 6480464 Carbamazepine affects the expression of SMAD3 mRNA CTD PMID:25979313 Smad3 Mouse carbofuran increases expression ISO Smad3 (Rattus norvegicus) 6480464 Carbofuran results in increased expression of SMAD3 mRNA CTD PMID:28982980 Smad3 Mouse carbofuran increases phosphorylation ISO Smad3 (Rattus norvegicus) 6480464 Carbofuran results in increased phosphorylation of SMAD3 protein CTD PMID:28982980 Smad3 Mouse carbofuran multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Carbofuran results in increased phosphorylation of SMAD3 protein] CTD PMID:28982980 Smad3 Mouse casticin increases expression ISO SMAD3 (Homo sapiens) 6480464 casticin results in increased expression of SMAD3 mRNA CTD PMID:27862857 Smad3 Mouse celastrol multiple interactions ISO SMAD3 (Homo sapiens) 6480464 celastrol inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:29789558 Smad3 Mouse ceruletide multiple interactions EXP 6480464 Shuangshen inhibits the reaction [Ceruletide results in increased expression of SMAD3 protein] CTD PMID:38113986 Smad3 Mouse ceruletide increases expression EXP 6480464 Ceruletide results in increased expression of SMAD3 protein CTD PMID:38113986 Smad3 Mouse CGP 52608 multiple interactions ISO SMAD3 (Homo sapiens) 6480464 CGP 52608 promotes the reaction [RORA protein binds to SMAD3 gene] CTD PMID:28238834 Smad3 Mouse CGS-21680 multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 8-(4-methoxyphenyl)-4-oxo-4 more ... CTD PMID:22063920 Smad3 Mouse chlorpyrifos increases phosphorylation ISO SMAD3 (Homo sapiens) 6480464 Chlorpyrifos results in increased phosphorylation of SMAD3 protein CTD PMID:32156659 Smad3 Mouse cholesterol multiple interactions EXP 6480464 [Cholesterol co-treated with 1 and 2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of SMAD3 mRNA CTD PMID:22129739 Smad3 Mouse choline multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SMAD3 gene more ... CTD PMID:20938992 and PMID:22915297 Smad3 Mouse chromium(6+) decreases expression ISO SMAD3 (Homo sapiens) 6480464 chromium hexavalent ion results in decreased expression of SMAD3 mRNA CTD PMID:30690063 Smad3 Mouse chrysin multiple interactions EXP 6480464 chrysin inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 mRNA] CTD PMID:26297989 Smad3 Mouse cisplatin decreases expression EXP 6480464 Cisplatin results in decreased expression of SMAD3 protein CTD PMID:23628706 Smad3 Mouse cisplatin increases expression ISO SMAD3 (Homo sapiens) 6480464 Cisplatin results in increased expression of SMAD3 mRNA CTD PMID:27392435 Smad3 Mouse cisplatin decreases expression ISO SMAD3 (Homo sapiens) 6480464 Cisplatin results in decreased expression of SMAD3 mRNA CTD PMID:19561079 Smad3 Mouse cisplatin multiple interactions ISO SMAD3 (Homo sapiens) 6480464 [Cisplatin co-treated with Paclitaxel] results in decreased expression of SMAD3 mRNA CTD PMID:20705681 Smad3 Mouse cocaine multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 Cocaine deficiency promotes the reaction [SMARCA4 protein binds to SMAD3 protein] CTD PMID:27422367 Smad3 Mouse coenzyme Q10 multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 coenzyme Q10 inhibits the reaction [sodium arsenite results in increased expression of SMAD3 mRNA] CTD PMID:27174133 Smad3 Mouse copper atom multiple interactions ISO SMAD3 (Homo sapiens) 6480464 [Chelating Agents binds to Copper] which results in increased expression of SMAD3 mRNA and [Disulfiram binds to Copper] which results in increased expression of SMAD3 mRNA CTD PMID:24690739 and PMID:30911355 Smad3 Mouse copper(0) multiple interactions ISO SMAD3 (Homo sapiens) 6480464 [Chelating Agents binds to Copper] which results in increased expression of SMAD3 mRNA and [Disulfiram binds to Copper] which results in increased expression of SMAD3 mRNA CTD PMID:24690739 and PMID:30911355 Smad3 Mouse copper(II) sulfate increases expression ISO SMAD3 (Homo sapiens) 6480464 Copper Sulfate results in increased expression of SMAD3 mRNA CTD PMID:19549813 Smad3 Mouse copper(II) sulfate increases phosphorylation EXP 6480464 Copper Sulfate results in increased phosphorylation of SMAD3 protein CTD PMID:33744278 Smad3 Mouse corosolic acid multiple interactions EXP 6480464 corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased methylation of SMAD3 gene] CTD PMID:32135139 Smad3 Mouse corticosterone decreases expression ISO Smad3 (Rattus norvegicus) 6480464 Corticosterone results in decreased expression of SMAD3 mRNA CTD PMID:29660438 and PMID:32663519 Smad3 Mouse coumestrol decreases expression ISO SMAD3 (Homo sapiens) 6480464 Coumestrol results in decreased expression of SMAD3 mRNA CTD PMID:19167446 Smad3 Mouse coumestrol multiple interactions ISO SMAD3 (Homo sapiens) 6480464 [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of SMAD3 mRNA CTD PMID:19167446 Smad3 Mouse crocidolite asbestos decreases expression EXP 6480464 Asbestos and Crocidolite results in decreased expression of SMAD3 mRNA CTD PMID:29279043 Smad3 Mouse curcumin multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 Curcumin inhibits the reaction [[SMAD4 protein binds to SMAD3 protein] which binds to PPARG promoter] more ... CTD PMID:16959952 more ... Smad3 Mouse cyclosporin A increases expression ISO SMAD3 (Homo sapiens) 6480464 Cyclosporine results in increased expression of SMAD3 mRNA CTD PMID:25562108 Smad3 Mouse cyclosporin A increases methylation ISO SMAD3 (Homo sapiens) 6480464 Cyclosporine results in increased methylation of SMAD3 promoter CTD PMID:27989131 Smad3 Mouse cytochalasin D affects localization ISO SMAD3 (Homo sapiens) 6480464 Cytochalasin D affects the localization of SMAD3 protein CTD PMID:25756282 Smad3 Mouse D-glucose multiple interactions ISO SMAD3 (Homo sapiens) 6480464 4-(4-((5-(4 more ... CTD PMID:17597607 and PMID:26045780 Smad3 Mouse D-glucose increases phosphorylation ISO SMAD3 (Homo sapiens) 6480464 Glucose results in increased phosphorylation of SMAD3 protein CTD PMID:26045780 Smad3 Mouse deguelin decreases phosphorylation ISO SMAD3 (Homo sapiens) 6480464 deguelin results in decreased phosphorylation of SMAD3 protein CTD PMID:22986522 Smad3 Mouse dexamethasone affects expression EXP 6480464 Dexamethasone affects the expression of SMAD3 mRNA CTD PMID:21277400 Smad3 Mouse dexamethasone decreases expression EXP 6480464 Dexamethasone results in decreased expression of SMAD3 mRNA CTD PMID:29329878 Smad3 Mouse diarsenic trioxide increases expression ISO SMAD3 (Homo sapiens) 6480464 Arsenic Trioxide results in increased expression of SMAD3 mRNA CTD PMID:29633893 Smad3 Mouse diarsenic trioxide decreases response to substance ISO SMAD3 (Homo sapiens) 6480464 SMAD3 protein results in decreased susceptibility to Arsenic Trioxide CTD PMID:20707922 Smad3 Mouse diarsenic trioxide multiple interactions ISO SMAD3 (Homo sapiens) 6480464 [Arsenic Trioxide results in increased expression of MIR491 mRNA] which results in decreased expression of SMAD3 mRNA more ... CTD PMID:21649584 more ... Smad3 Mouse diarsenic trioxide decreases expression ISO SMAD3 (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of SMAD3 mRNA and Arsenic Trioxide results in decreased expression of SMAD3 protein CTD PMID:25196641 more ... Smad3 Mouse dibenz[a,h]anthracene multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 [Benzo(a)pyrene co-treated with 1 more ... CTD PMID:18711122 Smad3 Mouse dibenzo[a,l]pyrene multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 [Benzo(a)pyrene co-treated with dibenzo(a and l)pyrene] affects the expression of SMAD3 mRNA CTD PMID:18711122 Smad3 Mouse dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of SMAD3 mRNA CTD PMID:21266533 Smad3 Mouse dimethyl sulfoxide multiple interactions ISO SMAD3 (Homo sapiens) 6480464 [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of SMAD3 protein modified form CTD PMID:35366062 Smad3 Mouse diminazene diaceturate decreases phosphorylation ISO SMAD3 (Homo sapiens) 6480464 diminazene aceturate results in decreased phosphorylation of SMAD3 protein CTD PMID:29977014 Smad3 Mouse dioxygen increases expression EXP 6480464 Oxygen deficiency results in increased expression of SMAD3 mRNA CTD PMID:24205000 Smad3 Mouse dioxygen multiple interactions ISO SMAD3 (Homo sapiens) 6480464 Oxygen affects the reaction [AHR protein results in decreased expression of SMAD3 mRNA] CTD PMID:27103661 Smad3 Mouse disodium selenite increases expression ISO SMAD3 (Homo sapiens) 6480464 Sodium Selenite results in increased expression of SMAD3 mRNA CTD PMID:18175754 Smad3 Mouse disodium selenite multiple interactions EXP 6480464 [Folic Acid co-treated with INS protein co-treated with TF protein co-treated with Sodium Selenite] results in increased expression of SMAD3 mRNA CTD PMID:32324263 Smad3 Mouse disulfiram multiple interactions ISO SMAD3 (Homo sapiens) 6480464 [Disulfiram binds to Copper] which results in increased expression of SMAD3 mRNA CTD PMID:24690739 Smad3 Mouse doxorubicin multiple interactions ISO SMAD3 (Homo sapiens) 6480464 Doxorubicin inhibits the reaction [TGFB1 protein results in increased localization of SMAD3 protein] CTD PMID:18606404 Smad3 Mouse doxorubicin increases phosphorylation EXP 6480464 Doxorubicin results in increased phosphorylation of SMAD3 protein CTD PMID:28318631 Smad3 Mouse doxorubicin multiple interactions EXP 6480464 Niclosamide inhibits the reaction [Doxorubicin results in increased phosphorylation of SMAD3 protein] CTD PMID:28318631 Smad3 Mouse doxorubicin decreases expression ISO SMAD3 (Homo sapiens) 6480464 Doxorubicin results in decreased expression of SMAD3 mRNA and Doxorubicin results in decreased expression of SMAD3 protein CTD PMID:18606404 and PMID:29803840 Smad3 Mouse ebselen multiple interactions ISO SMAD3 (Homo sapiens) 6480464 ebselen inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:21131394 Smad3 Mouse endosulfan multiple interactions ISO SMAD3 (Homo sapiens) 6480464 Endosulfan results in increased expression of and results in increased phosphorylation of SMAD3 protein and LY2109761 inhibits the reaction [Endosulfan results in increased phosphorylation of SMAD3 protein] CTD PMID:34856488 and PMID:36513242 Smad3 Mouse endosulfan increases phosphorylation ISO SMAD3 (Homo sapiens) 6480464 Endosulfan results in increased phosphorylation of SMAD3 protein CTD PMID:34856488 Smad3 Mouse Enterolactone decreases expression ISO SMAD3 (Homo sapiens) 6480464 2 and 3-bis(3'-hydroxybenzyl)butyrolactone results in decreased expression of SMAD3 mRNA CTD PMID:19167446 Smad3 Mouse Enterolactone multiple interactions ISO SMAD3 (Homo sapiens) 6480464 [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of SMAD3 mRNA CTD PMID:19167446 Smad3 Mouse ethanol multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 8-(4-methoxyphenyl)-4-oxo-4 more ... CTD PMID:21172400 more ... Smad3 Mouse ethanol affects splicing EXP 6480464 Ethanol affects the splicing of SMAD3 mRNA CTD PMID:30319688 Smad3 Mouse ethanol increases expression ISO SMAD3 (Homo sapiens) 6480464 Ethanol results in increased expression of SMAD3 mRNA CTD PMID:23378141 Smad3 Mouse ethanol increases expression ISO Smad3 (Rattus norvegicus) 6480464 Ethanol results in increased expression of SMAD3 protein CTD PMID:23274713 Smad3 Mouse ethanol increases phosphorylation ISO Smad3 (Rattus norvegicus) 6480464 Ethanol results in increased phosphorylation of SMAD3 protein CTD PMID:21172400 and PMID:22063920 Smad3 Mouse ethyl methanesulfonate increases expression ISO SMAD3 (Homo sapiens) 6480464 Ethyl Methanesulfonate results in increased expression of SMAD3 mRNA CTD PMID:23649840 Smad3 Mouse fenofibrate multiple interactions ISO SMAD3 (Homo sapiens) 6480464 Fenofibrate inhibits the reaction [SMAD3 protein results in increased expression of SERPINE1 mRNA] and NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [SMAD3 protein results in increased expression of SERPINE1 mRNA]] CTD PMID:19593819 Smad3 Mouse fenthion decreases expression EXP 6480464 Fenthion results in decreased expression of SMAD3 mRNA CTD PMID:34813904 Smad3 Mouse ferulic acid multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 ferulic acid inhibits the reaction [Thioacetamide results in increased phosphorylation of SMAD3 protein] CTD PMID:32278740 Smad3 Mouse fipronil decreases expression ISO Smad3 (Rattus norvegicus) 6480464 fipronil results in decreased expression of SMAD3 mRNA CTD PMID:23962444 Smad3 Mouse fluoranthene multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 [Benzo(a)pyrene co-treated with fluoranthene] affects the expression of SMAD3 mRNA CTD PMID:18711122 Smad3 Mouse fluoranthene multiple interactions EXP 6480464 [1-methylanthracene co-treated with fluoranthene] results in increased expression of SMAD3 mRNA CTD PMID:28329830 Smad3 Mouse flutamide decreases expression ISO Smad3 (Rattus norvegicus) 6480464 Flutamide results in decreased expression of SMAD3 mRNA and Flutamide results in decreased expression of SMAD3 protein CTD PMID:16166221 Smad3 Mouse folic acid multiple interactions EXP 6480464 6 more ... CTD PMID:20938992 more ... Smad3 Mouse folic acid multiple interactions ISO SMAD3 (Homo sapiens) 6480464 Folic Acid inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:29380373 Smad3 Mouse folic acid increases phosphorylation EXP 6480464 Folic Acid results in increased phosphorylation of SMAD3 protein CTD PMID:31447676 Smad3 Mouse formaldehyde increases expression ISO SMAD3 (Homo sapiens) 6480464 Formaldehyde results in increased expression of SMAD3 mRNA CTD PMID:23649840 Smad3 Mouse fulvestrant multiple interactions ISO SMAD3 (Homo sapiens) 6480464 [bisphenol A co-treated with Fulvestrant] affects the methylation of SMAD3 gene more ... CTD PMID:24308608 more ... Smad3 Mouse fulvestrant increases methylation ISO SMAD3 (Homo sapiens) 6480464 Fulvestrant results in increased methylation of SMAD3 gene CTD PMID:31601247 Smad3 Mouse galangin increases expression ISO SMAD3 (Homo sapiens) 6480464 galangin results in increased expression of SMAD3 mRNA CTD PMID:25268046 Smad3 Mouse galangin multiple interactions ISO SMAD3 (Homo sapiens) 6480464 LY2109761 inhibits the reaction [galangin results in increased phosphorylation of SMAD3 protein] CTD PMID:25268046 Smad3 Mouse galangin increases phosphorylation ISO SMAD3 (Homo sapiens) 6480464 galangin results in increased phosphorylation of SMAD3 protein CTD PMID:25268046 Smad3 Mouse gallic acid multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 Gallic Acid inhibits the reaction [Thioacetamide results in increased phosphorylation of SMAD3 protein] CTD PMID:32278740 Smad3 Mouse Ganoderic acid A multiple interactions EXP 6480464 ganoderic acid A inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of SMAD3 protein] CTD PMID:34029542 Smad3 Mouse genistein multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 Genistein inhibits the reaction [Ethanol results in increased expression of SMAD3 protein] and Genistein inhibits the reaction [Galactosamine results in increased phosphorylation of SMAD3 protein] CTD PMID:23274713 and PMID:27876602 Smad3 Mouse genistein multiple interactions ISO SMAD3 (Homo sapiens) 6480464 Genistein inhibits the reaction [bisphenol A results in decreased phosphorylation of SMAD3 protein] more ... CTD PMID:26407941 Smad3 Mouse genistein affects response to substance ISO SMAD3 (Homo sapiens) 6480464 SMAD3 protein affects the susceptibility to Genistein CTD PMID:22228119 Smad3 Mouse genistein decreases expression ISO SMAD3 (Homo sapiens) 6480464 Genistein results in decreased expression of SMAD3 mRNA and Genistein results in decreased expression of SMAD3 protein CTD PMID:22228119 Smad3 Mouse geraniol decreases expression ISO SMAD3 (Homo sapiens) 6480464 geraniol results in decreased expression of SMAD3 mRNA CTD PMID:27683099 Smad3 Mouse glucose multiple interactions ISO SMAD3 (Homo sapiens) 6480464 4-(4-((5-(4 more ... CTD PMID:17597607 and PMID:26045780 Smad3 Mouse glucose increases phosphorylation ISO SMAD3 (Homo sapiens) 6480464 Glucose results in increased phosphorylation of SMAD3 protein CTD PMID:26045780 Smad3 Mouse glyphosate decreases expression ISO SMAD3 (Homo sapiens) 6480464 Glyphosate results in decreased expression of SMAD3 mRNA CTD PMID:31295307 Smad3 Mouse heptachlor increases expression ISO SMAD3 (Homo sapiens) 6480464 Heptachlor results in increased expression of SMAD3 mRNA and Heptachlor results in increased expression of SMAD3 protein modified form CTD PMID:30719927 Smad3 Mouse hexachlorobenzene increases phosphorylation EXP 6480464 Hexachlorobenzene results in increased phosphorylation of SMAD3 protein CTD PMID:28923513 Smad3 Mouse hexachlorobenzene multiple interactions ISO SMAD3 (Homo sapiens) 6480464 AG 1879 inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of SMAD3 protein] more ... CTD PMID:27519288 Smad3 Mouse Honokiol multiple interactions ISO SMAD3 (Homo sapiens) 6480464 honokiol inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:32032644 Smad3 Mouse Honokiol multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 honokiol inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:21265825 Smad3 Mouse Honokiol multiple interactions EXP 6480464 honokiol inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD3 protein] CTD PMID:32032644 Smad3 Mouse hyaluronic acid multiple interactions ISO SMAD3 (Homo sapiens) 6480464 [4-(5-benzo(1 more ... CTD PMID:21520325 Smad3 Mouse hydrogen peroxide increases secretion EXP 6480464 Hydrogen Peroxide results in increased secretion of SMAD3 mRNA CTD PMID:21179422 Smad3 Mouse hydrogen peroxide increases phosphorylation ISO SMAD3 (Homo sapiens) 6480464 Hydrogen Peroxide results in increased phosphorylation of SMAD3 protein CTD PMID:15147944 and PMID:24762191 Smad3 Mouse hydrogen peroxide multiple interactions ISO SMAD3 (Homo sapiens) 6480464 arsenic trioxide inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of SMAD3 protein] more ... CTD PMID:24762191 Smad3 Mouse irbesartan multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 [benazepril co-treated with irbesartan] affects the expression of SMAD3 mRNA and [benazepril co-treated with irbesartan] affects the expression of SMAD3 protein CTD PMID:16635409 Smad3 Mouse irbesartan affects expression ISO Smad3 (Rattus norvegicus) 6480464 irbesartan affects the expression of SMAD3 mRNA and irbesartan affects the expression of SMAD3 protein CTD PMID:16635409 Smad3 Mouse irinotecan decreases expression ISO SMAD3 (Homo sapiens) 6480464 Irinotecan analog results in decreased expression of SMAD3 mRNA CTD PMID:18927307 Smad3 Mouse isoprenaline increases expression ISO Smad3 (Rattus norvegicus) 6480464 Isoproterenol results in increased expression of SMAD3 mRNA CTD PMID:35014750 Smad3 Mouse isorhamnetin multiple interactions ISO SMAD3 (Homo sapiens) 6480464 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] and NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]] CTD PMID:27151496 Smad3 Mouse ivermectin decreases phosphorylation ISO SMAD3 (Homo sapiens) 6480464 Ivermectin results in decreased phosphorylation of SMAD3 protein CTD PMID:33955514 Smad3 Mouse L-methionine multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SMAD3 gene more ... CTD PMID:20938992 and PMID:22915297 Smad3 Mouse lactucin decreases expression EXP 6480464 lactucin results in decreased expression of SMAD3 protein CTD PMID:39164375 Smad3 Mouse lactucin decreases expression ISO Smad3 (Rattus norvegicus) 6480464 lactucin results in decreased expression of SMAD3 protein CTD PMID:39164375 Smad3 Mouse lead diacetate increases methylation ISO Smad3 (Rattus norvegicus) 6480464 lead acetate results in increased methylation of SMAD3 gene CTD PMID:29571894 Smad3 Mouse leptomycin B multiple interactions EXP 6480464 leptomycin B inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]] more ... CTD PMID:26354774 Smad3 Mouse linoleic acid decreases abundance EXP 6480464 SMAD3 protein results in decreased abundance of Linoleic Acid CTD PMID:23034213 Smad3 Mouse lipoic acid multiple interactions EXP 6480464 Thioctic Acid inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD3 protein] CTD PMID:35187969 Smad3 Mouse lipopolysaccharide multiple interactions EXP 6480464 [Lipopolysaccharides results in increased phosphorylation of SMAD3 protein] promotes the reaction [Lipopolysaccharides inhibits the reaction [TGFB1 protein results in increased expression of SMAD6 mRNA]] more ... CTD PMID:21295571 Smad3 Mouse lipopolysaccharide increases response to substance EXP 6480464 SMAD3 protein results in increased susceptibility to Lipopolysaccharides CTD PMID:21131441 Smad3 Mouse lipopolysaccharide increases phosphorylation EXP 6480464 Lipopolysaccharides results in increased phosphorylation of SMAD3 protein CTD PMID:21295571 Smad3 Mouse lithocholic acid multiple interactions EXP 6480464 SMAD3 protein promotes the reaction [Lithocholic Acid results in decreased expression of SLC10A1 mRNA] more ... CTD PMID:23034213 Smad3 Mouse lithocholic acid increases response to substance EXP 6480464 SMAD3 protein results in increased susceptibility to Lithocholic Acid CTD PMID:23034213 Smad3 Mouse LY-2157299 multiple interactions ISO SMAD3 (Homo sapiens) 6480464 LY-2157299 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:35122773 Smad3 Mouse LY-2157299 multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 LY-2157299 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:35122773 Smad3 Mouse lycopene increases expression ISO SMAD3 (Homo sapiens) 6480464 lycopene results in increased expression of SMAD3 mRNA CTD PMID:16886892 Smad3 Mouse melphalan decreases expression ISO SMAD3 (Homo sapiens) 6480464 Melphalan results in decreased expression of SMAD3 mRNA CTD PMID:22363485 Smad3 Mouse menadione affects expression ISO SMAD3 (Homo sapiens) 6480464 Vitamin K 3 affects the expression of SMAD3 mRNA CTD PMID:20044591 Smad3 Mouse methamphetamine increases expression ISO Smad3 (Rattus norvegicus) 6480464 Methamphetamine results in increased expression of SMAD3 mRNA CTD PMID:19564919 Smad3 Mouse methamphetamine multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 [Methamphetamine co-treated with SCH 23390] results in increased expression of SMAD3 mRNA CTD PMID:19564919 Smad3 Mouse methapyrilene increases methylation ISO SMAD3 (Homo sapiens) 6480464 Methapyrilene results in increased methylation of SMAD3 intron CTD PMID:30157460 Smad3 Mouse methoxychlor affects methylation ISO Smad3 (Rattus norvegicus) 6480464 Methoxychlor affects the methylation of SMAD3 gene CTD PMID:35440735 Smad3 Mouse Methylazoxymethanol acetate increases expression ISO Smad3 (Rattus norvegicus) 6480464 Methylazoxymethanol Acetate results in increased expression of SMAD3 mRNA CTD PMID:28349193 Smad3 Mouse methylmercury chloride increases expression EXP 6480464 methylmercuric chloride results in increased expression of SMAD3 mRNA CTD PMID:20061341 Smad3 Mouse methylmercury chloride decreases expression ISO SMAD3 (Homo sapiens) 6480464 methylmercuric chloride results in decreased expression of SMAD3 mRNA CTD PMID:28001369 Smad3 Mouse methylparaben decreases expression ISO SMAD3 (Homo sapiens) 6480464 methylparaben results in decreased expression of SMAD3 mRNA CTD PMID:31745603 Smad3 Mouse mirtazapine multiple interactions EXP 6480464 mirtazapine inhibits the reaction [Thioacetamide results in increased expression of SMAD3 protein modified form] CTD PMID:28623179 Smad3 Mouse monocrotaline increases phosphorylation ISO SMAD3 (Homo sapiens) 6480464 Monocrotaline results in increased phosphorylation of SMAD3 protein CTD PMID:36942326 Smad3 Mouse monocrotaline multiple interactions ISO SMAD3 (Homo sapiens) 6480464 Propylthiouracil inhibits the reaction [Monocrotaline results in increased expression of SMAD3 protein] CTD PMID:36942326 Smad3 Mouse Muraglitazar decreases expression ISO Smad3 (Rattus norvegicus) 6480464 muraglitazar results in decreased expression of SMAD3 mRNA CTD PMID:21515302 Smad3 Mouse N(gamma)-nitro-L-arginine methyl ester multiple interactions EXP 6480464 [Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased phosphorylation of SMAD3 protein] and [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased phosphorylation of SMAD3 protein CTD PMID:38282657 Smad3 Mouse N-acetyl-L-cysteine multiple interactions ISO SMAD3 (Homo sapiens) 6480464 [Acetylcysteine co-treated with Cadmium Chloride co-treated with sodium arsenite] results in decreased expression of SMAD3 mRNA more ... CTD PMID:21131394 more ... Smad3 Mouse N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased phosphorylation of SMAD3 protein] CTD PMID:38488660 Smad3 Mouse N-acetyl-L-cysteine decreases phosphorylation ISO SMAD3 (Homo sapiens) 6480464 Acetylcysteine results in decreased phosphorylation of SMAD3 protein CTD PMID:34687772 Smad3 Mouse N-nitrosodiethylamine multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD3 protein more ... CTD PMID:15368444 and PMID:19418558 Smad3 Mouse N-nitrosodiethylamine decreases expression EXP 6480464 Diethylnitrosamine results in decreased expression of SMAD3 protein modified form CTD PMID:33290806 Smad3 Mouse N-nitrosodiethylamine multiple interactions EXP 6480464 salvianolic acid B affects the reaction [Diethylnitrosamine results in decreased expression of SMAD3 protein modified form] more ... CTD PMID:33290806 Smad3 Mouse N-nitrosodiethylamine increases phosphorylation EXP 6480464 Diethylnitrosamine results in increased phosphorylation of SMAD3 protein CTD PMID:33290806 Smad3 Mouse N-nitrosodiethylamine affects phosphorylation ISO Smad3 (Rattus norvegicus) 6480464 Diethylnitrosamine affects the phosphorylation of SMAD3 protein CTD PMID:19418558 Smad3 Mouse naringin multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 naringin inhibits the reaction [sodium arsenite results in increased expression of SMAD3 mRNA] CTD PMID:27174133 Smad3 Mouse nickel atom multiple interactions EXP 6480464 [nickel chloride results in increased abundance of Nickel] which results in increased phosphorylation of SMAD3 mRNA more ... CTD PMID:38488660 Smad3 Mouse nickel dichloride multiple interactions EXP 6480464 [nickel chloride results in increased abundance of Nickel] which results in increased phosphorylation of SMAD3 mRNA more ... CTD PMID:38488660 Smad3 Mouse niclosamide multiple interactions ISO SMAD3 (Homo sapiens) 6480464 HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]] more ... CTD PMID:28318631 and PMID:36870549 Smad3 Mouse niclosamide multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:28318631 Smad3 Mouse niclosamide multiple interactions EXP 6480464 Niclosamide inhibits the reaction [Doxorubicin results in increased phosphorylation of SMAD3 protein] CTD PMID:28318631 Smad3 Mouse nicotinamide increases phosphorylation ISO Smad3 (Rattus norvegicus) 6480464 Niacinamide results in increased phosphorylation of SMAD3 protein CTD PMID:38555046 Smad3 Mouse nicotinamide increases expression ISO Smad3 (Rattus norvegicus) 6480464 Niacinamide results in increased expression of SMAD3 mRNA CTD PMID:38555046 Smad3 Mouse nicotine multiple interactions EXP 6480464 [Nicotine co-treated with 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 Smad3 Mouse nicotine multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 Nicotine results in increased expression of and results in increased phosphorylation of SMAD3 protein CTD PMID:22691361 Smad3 Mouse nicotine decreases expression ISO Smad3 (Rattus norvegicus) 6480464 Nicotine results in decreased expression of SMAD3 mRNA CTD PMID:29660438 Smad3 Mouse nitric oxide multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 [SMAD4 protein co-treated with SMAD3 protein] affects the susceptibility to Nitric Oxide and Nitric Oxide results in increased activity of [SMAD4 protein binds to SMAD3 protein] CTD PMID:15949472 Smad3 Mouse nitrofen decreases expression EXP 6480464 nitrofen results in decreased expression of SMAD3 mRNA CTD PMID:12149686 Smad3 Mouse Nonylphenol decreases phosphorylation ISO SMAD3 (Homo sapiens) 6480464 nonylphenol results in decreased phosphorylation of SMAD3 protein CTD PMID:26407941 Smad3 Mouse Nonylphenol multiple interactions ISO SMAD3 (Homo sapiens) 6480464 fulvestrant inhibits the reaction [nonylphenol results in decreased phosphorylation of SMAD3 protein] and Genistein inhibits the reaction [nonylphenol results in decreased phosphorylation of SMAD3 protein] CTD PMID:26407941 Smad3 Mouse ochratoxin A increases expression EXP 6480464 ochratoxin A results in increased expression of SMAD3 mRNA CTD PMID:32617660 Smad3 Mouse ochratoxin A increases response to substance ISO SMAD3 (Homo sapiens) 6480464 SMAD3 results in increased susceptibility to ochratoxin A CTD PMID:35543154 Smad3 Mouse ochratoxin A multiple interactions EXP 6480464 ochratoxin A results in increased expression of and results in increased phosphorylation of SMAD3 protein CTD PMID:35543154 Smad3 Mouse ochratoxin A multiple interactions ISO SMAD3 (Homo sapiens) 6480464 4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide inhibits the reaction [ochratoxin A results in increased expression of SMAD3 mRNA] more ... CTD PMID:32617660 and PMID:35543154 Smad3 Mouse ochratoxin A increases expression ISO SMAD3 (Homo sapiens) 6480464 ochratoxin A results in increased expression of SMAD3 mRNA CTD PMID:32617660 and PMID:35543154 Smad3 Mouse oridonin multiple interactions ISO SMAD3 (Homo sapiens) 6480464 oridonin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:30243739 Smad3 Mouse osthole multiple interactions ISO SMAD3 (Homo sapiens) 6480464 [platycodin D co-treated with osthol] inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] more ... CTD PMID:23603464 Smad3 Mouse ozone multiple interactions ISO SMAD3 (Homo sapiens) 6480464 [Aripiprazole co-treated with Ozone] results in increased expression of SMAD3 mRNA CTD PMID:31476115 Smad3 Mouse ozone increases expression ISO SMAD3 (Homo sapiens) 6480464 Ozone results in increased expression of SMAD3 mRNA CTD PMID:31476115 Smad3 Mouse paclitaxel multiple interactions ISO SMAD3 (Homo sapiens) 6480464 [Cisplatin co-treated with Paclitaxel] results in decreased expression of SMAD3 mRNA CTD PMID:20705681 Smad3 Mouse paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of SMAD3 mRNA CTD PMID:11752693 Smad3 Mouse paracetamol multiple interactions EXP 6480464 4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide inhibits the reaction [Acetaminophen results in increased phosphorylation of SMAD3 protein] CTD PMID:31132129 Smad3 Mouse paracetamol increases expression ISO SMAD3 (Homo sapiens) 6480464 Acetaminophen results in increased expression of SMAD3 mRNA CTD PMID:22230336 Smad3 Mouse paracetamol decreases expression ISO SMAD3 (Homo sapiens) 6480464 Acetaminophen results in decreased expression of SMAD3 mRNA CTD PMID:21420995 Smad3 Mouse paracetamol increases phosphorylation EXP 6480464 Acetaminophen results in increased phosphorylation of SMAD3 protein CTD PMID:31132129 Smad3 Mouse paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of SMAD3 mRNA CTD PMID:17562736 Smad3 Mouse paraquat increases response to substance EXP 6480464 SMAD3 protein results in increased susceptibility to Paraquat CTD PMID:22581813 Smad3 Mouse paraquat increases phosphorylation ISO SMAD3 (Homo sapiens) 6480464 Paraquat results in increased phosphorylation of SMAD3 protein CTD PMID:30265375 Smad3 Mouse paraquat multiple interactions EXP 6480464 Xuebijing inhibits the reaction [Paraquat results in increased expression of SMAD3 mRNA] and Xuebijing inhibits the reaction [Paraquat results in increased phosphorylation of SMAD3 protein] CTD PMID:32462952 Smad3 Mouse paraquat increases phosphorylation EXP 6480464 Paraquat results in increased phosphorylation of SMAD3 protein CTD PMID:32462952 Smad3 Mouse paraquat increases expression EXP 6480464 Paraquat results in increased expression of SMAD3 mRNA CTD PMID:32462952 Smad3 Mouse paraquat multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 LY2109761 inhibits the reaction [Paraquat results in increased expression of and results in increased secretion of SMAD3 protein] more ... CTD PMID:33000210 Smad3 Mouse paraquat increases expression ISO Smad3 (Rattus norvegicus) 6480464 Paraquat results in increased expression of SMAD3 mRNA CTD PMID:33000210 Smad3 Mouse paraquat multiple interactions ISO SMAD3 (Homo sapiens) 6480464 sodium bisulfide inhibits the reaction [Paraquat results in increased phosphorylation of SMAD3 protein] and TGFB1 protein promotes the reaction [Paraquat results in increased expression of SMAD3 protein modified form] CTD PMID:27682480 and PMID:30265375 Smad3 Mouse paraquat increases expression ISO SMAD3 (Homo sapiens) 6480464 Paraquat results in increased expression of SMAD3 protein modified form CTD PMID:27682480 Smad3 Mouse patulin increases phosphorylation ISO Smad3 (Rattus norvegicus) 6480464 Patulin results in increased phosphorylation of SMAD3 protein CTD PMID:34896196 Smad3 Mouse perfluorohexanesulfonic acid decreases expression ISO SMAD3 (Homo sapiens) 6480464 perfluorohexanesulfonic acid results in decreased expression of SMAD3 mRNA CTD PMID:25812627 Smad3 Mouse perfluorohexanesulfonic acid decreases expression EXP 6480464 perfluorohexanesulfonic acid results in decreased expression of SMAD3 mRNA CTD PMID:37995155 Smad3 Mouse perfluorononanoic acid decreases expression ISO SMAD3 (Homo sapiens) 6480464 perfluoro-n-nonanoic acid results in decreased expression of SMAD3 mRNA CTD PMID:25812627 Smad3 Mouse perfluorooctane-1-sulfonic acid decreases expression ISO SMAD3 (Homo sapiens) 6480464 perfluorooctane sulfonic acid results in decreased expression of SMAD3 mRNA CTD PMID:25812627 Smad3 Mouse perfluorooctanoic acid decreases expression ISO SMAD3 (Homo sapiens) 6480464 perfluorooctanoic acid results in decreased expression of SMAD3 mRNA CTD PMID:25812627 Smad3 Mouse perindopril multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein] CTD PMID:16872305 Smad3 Mouse perindopril decreases expression ISO Smad3 (Rattus norvegicus) 6480464 Perindopril results in decreased expression of SMAD3 protein CTD PMID:15619341 Smad3 Mouse phenylarsine oxide multiple interactions ISO SMAD3 (Homo sapiens) 6480464 oxophenylarsine inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:31652400 Smad3 Mouse phenylmercury acetate multiple interactions ISO SMAD3 (Homo sapiens) 6480464 Phenylmercuric Acetate inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:31652400 Smad3 Mouse phloroglucinol multiple interactions ISO SMAD3 (Homo sapiens) 6480464 Phloroglucinol analog inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:26054450 Smad3 Mouse phorbol 13-acetate 12-myristate multiple interactions EXP 6480464 corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased methylation of SMAD3 gene] CTD PMID:32135139 Smad3 Mouse phorbol 13-acetate 12-myristate increases methylation EXP 6480464 Tetradecanoylphorbol Acetate results in increased methylation of SMAD3 gene CTD PMID:32135139 Smad3 Mouse Phyllanthin multiple interactions EXP 6480464 phyllanthin inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein] CTD PMID:26337812 Smad3 Mouse picoxystrobin decreases expression ISO SMAD3 (Homo sapiens) 6480464 picoxystrobin results in decreased expression of SMAD3 mRNA CTD PMID:33512557 Smad3 Mouse picrotoxin increases expression ISO Smad3 (Rattus norvegicus) 6480464 Picrotoxin results in increased expression of SMAD3 mRNA CTD PMID:15170462 Smad3 Mouse pinostrobin increases expression ISO SMAD3 (Homo sapiens) 6480464 pinostrobin results in increased expression of SMAD3 mRNA CTD PMID:37777166 Smad3 Mouse pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of SMAD3 mRNA CTD PMID:20813756 Smad3 Mouse platycodin D multiple interactions ISO SMAD3 (Homo sapiens) 6480464 [platycodin D co-treated with osthol] inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] more ... CTD PMID:23603464 Smad3 Mouse potassium chromate multiple interactions ISO SMAD3 (Homo sapiens) 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SMAD3 mRNA CTD PMID:22079256 Smad3 Mouse potassium chromate decreases expression ISO SMAD3 (Homo sapiens) 6480464 potassium chromate(VI) results in decreased expression of SMAD3 mRNA CTD PMID:22079256 and PMID:22714537 Smad3 Mouse progesterone multiple interactions ISO SMAD3 (Homo sapiens) 6480464 [4-(5-benzo(1 more ... CTD PMID:20660070 and PMID:21520325 Smad3 Mouse progesterone decreases expression ISO SMAD3 (Homo sapiens) 6480464 Progesterone results in decreased expression of SMAD3 mRNA CTD PMID:20864642 Smad3 Mouse propiconazole increases localization ISO SMAD3 (Homo sapiens) 6480464 propiconazole results in increased localization of SMAD3 protein CTD PMID:34170130 Smad3 Mouse quercetin multiple interactions ISO SMAD3 (Homo sapiens) 6480464 Quercetin inhibits the reaction [SMAD2 protein modified form binds to SMAD3 protein modified form binds to SMAD4 protein] and SHH protein inhibits the reaction [Quercetin results in decreased phosphorylation of SMAD3 protein] CTD PMID:15580028 and PMID:33070227 Smad3 Mouse quercetin multiple interactions EXP 6480464 Quercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SMAD3 mRNA] and Quercetin promotes the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:21216973 and PMID:22915297 Smad3 Mouse quercetin decreases phosphorylation ISO SMAD3 (Homo sapiens) 6480464 Quercetin results in decreased phosphorylation of SMAD3 protein CTD PMID:33070227 Smad3 Mouse quercetin decreases expression ISO SMAD3 (Homo sapiens) 6480464 Quercetin results in decreased expression of SMAD3 protein and Quercetin results in decreased expression of SMAD3 protein modified form CTD PMID:15580028 Smad3 Mouse quercitrin increases expression ISO SMAD3 (Homo sapiens) 6480464 quercitrin results in increased expression of SMAD3 mRNA CTD PMID:25193878 Smad3 Mouse rac-lactic acid increases expression ISO SMAD3 (Homo sapiens) 6480464 Lactic Acid results in increased expression of SMAD3 mRNA CTD PMID:30851411 Smad3 Mouse reactive oxygen species affects expression ISO SMAD3 (Homo sapiens) 6480464 Reactive Oxygen Species affects the expression of SMAD3 mRNA CTD PMID:25800948 Smad3 Mouse resveratrol multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 resveratrol inhibits the reaction [Streptozocin results in increased phosphorylation of SMAD3 protein] CTD PMID:21300041 Smad3 Mouse resveratrol increases expression ISO Smad3 (Rattus norvegicus) 6480464 Resveratrol results in increased expression of SMAD3 mRNA CTD PMID:38555046 Smad3 Mouse resveratrol decreases phosphorylation ISO Smad3 (Rattus norvegicus) 6480464 Resveratrol results in decreased phosphorylation of SMAD3 protein CTD PMID:38555046 Smad3 Mouse resveratrol multiple interactions ISO SMAD3 (Homo sapiens) 6480464 resveratrol inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:27345520 Smad3 Mouse resveratrol multiple interactions EXP 6480464 resveratrol inhibits the reaction [lipopolysaccharide and Escherichia coli O111 B4 results in increased phosphorylation of SMAD3 protein] CTD PMID:25234611 Smad3 Mouse resveratrol decreases expression ISO SMAD3 (Homo sapiens) 6480464 resveratrol results in decreased expression of SMAD3 mRNA and resveratrol results in decreased expression of SMAD3 protein CTD PMID:18089832 and PMID:25721869 Smad3 Mouse resveratrol decreases acetylation ISO Smad3 (Rattus norvegicus) 6480464 resveratrol results in decreased acetylation of SMAD3 protein CTD PMID:20651248 Smad3 Mouse resveratrol decreases acetylation EXP 6480464 resveratrol results in decreased acetylation of SMAD3 protein CTD PMID:20651248 Smad3 Mouse resveratrol decreases phosphorylation EXP 6480464 resveratrol results in decreased phosphorylation of SMAD3 protein CTD PMID:21679764 Smad3 Mouse rotenone decreases expression ISO SMAD3 (Homo sapiens) 6480464 Rotenone results in decreased expression of SMAD3 mRNA CTD PMID:33512557 Smad3 Mouse S-(1,2-dichlorovinyl)-L-cysteine decreases expression ISO SMAD3 (Homo sapiens) 6480464 S-(1 and 2-dichlorovinyl)cysteine results in decreased expression of SMAD3 mRNA CTD PMID:33725128 and PMID:35811015 Smad3 Mouse salvianolic acid B multiple interactions ISO SMAD3 (Homo sapiens) 6480464 salvianolic acid B affects the reaction [TGFB1 protein affects the reaction [SMAD3 protein mutant form affects the expression of CDKN1A protein]] CTD PMID:33290806 Smad3 Mouse salvianolic acid B affects response to substance EXP 6480464 SMAD3 protein modified form affects the susceptibility to salvianolic acid B CTD PMID:33290806 Smad3 Mouse salvianolic acid B multiple interactions EXP 6480464 salvianolic acid B affects the reaction [Diethylnitrosamine results in decreased expression of SMAD3 protein modified form] more ... CTD PMID:33290806 Smad3 Mouse SB 203580 multiple interactions ISO SMAD3 (Homo sapiens) 6480464 SB 203580 inhibits the reaction [TGFB2 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:18253093 Smad3 Mouse SB 431542 decreases phosphorylation ISO Smad3 (Rattus norvegicus) 6480464 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased phosphorylation of SMAD3 protein CTD PMID:28982980 Smad3 Mouse SB 431542 multiple interactions EXP 6480464 4-(5-benzo(1 more ... CTD PMID:21586554 and PMID:29127033 Smad3 Mouse SB 431542 multiple interactions ISO SMAD3 (Homo sapiens) 6480464 4-(5-benzo(1 more ... CTD PMID:21520325 and PMID:28871336 Smad3 Mouse SB 431542 decreases phosphorylation EXP 6480464 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased phosphorylation of SMAD3 protein CTD PMID:29127033 Smad3 Mouse SB 431542 multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Carbofuran results in increased phosphorylation of SMAD3 protein] CTD PMID:28982980 Smad3 Mouse SCH 23390 increases expression ISO Smad3 (Rattus norvegicus) 6480464 SCH 23390 results in increased expression of SMAD3 mRNA CTD PMID:19564919 Smad3 Mouse SCH 23390 multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 [Methamphetamine co-treated with SCH 23390] results in increased expression of SMAD3 mRNA CTD PMID:19564919 Smad3 Mouse serpentine asbestos multiple interactions ISO SMAD3 (Homo sapiens) 6480464 [Asbestos more ... CTD PMID:25358858 Smad3 Mouse sevoflurane multiple interactions EXP 6480464 TGFB1 protein affects the reaction [sevoflurane affects the localization of SMAD3 protein] CTD PMID:18434384 Smad3 Mouse sevoflurane affects response to substance EXP 6480464 SMAD3 protein affects the susceptibility to sevoflurane CTD PMID:18434384 Smad3 Mouse silicon dioxide increases phosphorylation ISO SMAD3 (Homo sapiens) 6480464 Silicon Dioxide results in increased phosphorylation of SMAD3 protein CTD PMID:32097614 Smad3 Mouse silicon dioxide multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 BMP7 protein inhibits the reaction [Silicon Dioxide results in increased expression of SMAD3 protein] CTD PMID:25733726 Smad3 Mouse silicon dioxide increases expression ISO Smad3 (Rattus norvegicus) 6480464 Silicon Dioxide results in increased expression of SMAD3 protein CTD PMID:25733726 Smad3 Mouse silicon dioxide multiple interactions ISO SMAD3 (Homo sapiens) 6480464 NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased phosphorylation of SMAD3 protein]] and tanshinone inhibits the reaction [Silicon Dioxide results in increased phosphorylation of SMAD3 protein] CTD PMID:32097614 Smad3 Mouse silver atom increases expression ISO SMAD3 (Homo sapiens) 6480464 Silver results in increased expression of SMAD3 mRNA CTD PMID:28959546 Smad3 Mouse silver(0) increases expression ISO SMAD3 (Homo sapiens) 6480464 Silver results in increased expression of SMAD3 mRNA CTD PMID:28959546 Smad3 Mouse silver(1+) nitrate decreases expression ISO SMAD3 (Homo sapiens) 6480464 Silver Nitrate analog results in decreased expression of SMAD3 mRNA CTD PMID:22831968 Smad3 Mouse silver(1+) nitrate increases expression ISO SMAD3 (Homo sapiens) 6480464 Silver Nitrate results in increased expression of SMAD3 mRNA CTD PMID:22831968 Smad3 Mouse simvastatin increases expression EXP 6480464 Simvastatin results in increased expression of SMAD3 mRNA CTD PMID:18310456 Smad3 Mouse simvastatin increases phosphorylation EXP 6480464 Simvastatin results in increased phosphorylation of SMAD3 protein CTD PMID:33034787 Smad3 Mouse simvastatin multiple interactions EXP 6480464 FST protein inhibits the reaction [Simvastatin results in increased phosphorylation of SMAD3 protein] CTD PMID:33034787 Smad3 Mouse simvastatin decreases phosphorylation ISO Smad3 (Rattus norvegicus) 6480464 Simvastatin results in decreased phosphorylation of SMAD3 protein CTD PMID:19659652 Smad3 Mouse sodium arsenate increases expression EXP 6480464 sodium arsenate results in increased expression of SMAD3 mRNA CTD PMID:21795629 Smad3 Mouse sodium arsenite multiple interactions EXP 6480464 IFNG protein inhibits the reaction [sodium arsenite results in increased expression of and results in increased phosphorylation of SMAD3 protein] more ... CTD PMID:17003472 and PMID:23732083 Smad3 Mouse sodium arsenite multiple interactions ISO SMAD3 (Homo sapiens) 6480464 [Acetylcysteine co-treated with Cadmium Chloride co-treated with sodium arsenite] results in decreased expression of SMAD3 mRNA CTD PMID:29408318 Smad3 Mouse sodium arsenite increases phosphorylation ISO Smad3 (Rattus norvegicus) 6480464 sodium arsenite results in increased phosphorylation of SMAD3 protein CTD PMID:21605584 Smad3 Mouse sodium arsenite increases expression ISO Smad3 (Rattus norvegicus) 6480464 sodium arsenite results in increased expression of SMAD3 mRNA and sodium arsenite results in increased expression of SMAD3 protein modified form CTD PMID:27174133 more ... Smad3 Mouse sodium arsenite multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 candesartan cilexetil inhibits the reaction [sodium arsenite results in increased expression of SMAD3 protein modified form] more ... CTD PMID:21605584 more ... Smad3 Mouse sodium arsenite decreases phosphorylation EXP 6480464 sodium arsenite results in decreased phosphorylation of SMAD3 protein CTD PMID:23732083 Smad3 Mouse sodium fluoride multiple interactions EXP 6480464 4-(5-benzo(1 more ... CTD PMID:29127033 Smad3 Mouse sodium fluoride increases expression EXP 6480464 Sodium Fluoride results in increased expression of SMAD3 mRNA CTD PMID:29127033 Smad3 Mouse sorafenib affects localization EXP 6480464 sorafenib affects the localization of SMAD3 protein CTD PMID:21360571 Smad3 Mouse sorafenib multiple interactions EXP 6480464 sorafenib inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:21360571 Smad3 Mouse sphingosine 1-phosphate increases phosphorylation ISO Smad3 (Rattus norvegicus) 6480464 sphingosine 1-phosphate results in increased phosphorylation of SMAD3 protein CTD PMID:37169277 Smad3 Mouse streptozocin multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 resveratrol inhibits the reaction [Streptozocin results in increased phosphorylation of SMAD3 protein] CTD PMID:21300041 Smad3 Mouse streptozocin multiple interactions EXP 6480464 [fatostatin co-treated with Streptozocin] results in increased phosphorylation of SMAD3 protein more ... CTD PMID:29420703 and PMID:38282657 Smad3 Mouse streptozocin increases phosphorylation EXP 6480464 Streptozocin results in increased phosphorylation of SMAD3 protein CTD PMID:29420703 Smad3 Mouse streptozocin increases phosphorylation ISO Smad3 (Rattus norvegicus) 6480464 Streptozocin results in increased phosphorylation of SMAD3 protein CTD PMID:21300041 Smad3 Mouse tacrolimus hydrate multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 Tacrolimus inhibits the reaction [Paraquat results in increased expression of and results in increased secretion of SMAD3 protein] and Tacrolimus inhibits the reaction [Paraquat results in increased expression of SMAD3 mRNA] CTD PMID:33000210 Smad3 Mouse tamoxifen multiple interactions ISO SMAD3 (Homo sapiens) 6480464 Tamoxifen promotes the reaction [Tretinoin results in increased phosphorylation of SMAD3 protein] CTD PMID:17098229 Smad3 Mouse tamoxifen multiple interactions EXP 6480464 [Tamoxifen co-treated with Zearalenone] results in increased expression of SMAD3 mRNA CTD PMID:30138655 Smad3 Mouse tamoxifen increases phosphorylation ISO SMAD3 (Homo sapiens) 6480464 Tamoxifen results in increased phosphorylation of SMAD3 protein CTD PMID:17098229 Smad3 Mouse Tanshinone I multiple interactions ISO SMAD3 (Homo sapiens) 6480464 NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased phosphorylation of SMAD3 protein]] and tanshinone inhibits the reaction [Silicon Dioxide results in increased phosphorylation of SMAD3 protein] CTD PMID:32097614 Smad3 Mouse tauro-beta-muricholic acid increases abundance EXP 6480464 SMAD3 protein results in increased abundance of tauromuricholic acid CTD PMID:23034213 Smad3 Mouse taurochenodeoxycholic acid increases abundance EXP 6480464 SMAD3 protein results in increased abundance of Taurochenodeoxycholic Acid CTD PMID:23034213 Smad3 Mouse taurolithocholic acid increases abundance EXP 6480464 SMAD3 protein results in increased abundance of Taurolithocholic Acid CTD PMID:23034213 Smad3 Mouse tauroursodeoxycholic acid increases abundance EXP 6480464 SMAD3 protein results in increased abundance of ursodoxicoltaurine CTD PMID:23034213 Smad3 Mouse temozolomide increases expression ISO SMAD3 (Homo sapiens) 6480464 Temozolomide results in increased expression of SMAD3 mRNA CTD PMID:31758290 Smad3 Mouse tert-butyl hydroperoxide increases expression ISO SMAD3 (Homo sapiens) 6480464 tert-Butylhydroperoxide results in increased expression of SMAD3 mRNA CTD PMID:27509014 Smad3 Mouse tert-butyl hydroperoxide increases methylation ISO SMAD3 (Homo sapiens) 6480464 tert-Butylhydroperoxide results in increased methylation of SMAD3 gene CTD PMID:27509014 Smad3 Mouse Tesaglitazar decreases expression ISO Smad3 (Rattus norvegicus) 6480464 tesaglitazar results in decreased expression of SMAD3 mRNA CTD PMID:21515302 Smad3 Mouse testosterone increases expression EXP 6480464 Testosterone results in increased expression of SMAD3 mRNA CTD PMID:22138414 Smad3 Mouse tetrachloromethane increases phosphorylation ISO Smad3 (Rattus norvegicus) 6480464 Carbon Tetrachloride results in increased phosphorylation of SMAD3 protein CTD PMID:24211420 and PMID:25150141 Smad3 Mouse tetrachloromethane increases phosphorylation EXP 6480464 Carbon Tetrachloride results in increased phosphorylation of SMAD3 protein CTD PMID:26337812 more ... Smad3 Mouse tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of SMAD3 mRNA and Carbon Tetrachloride results in increased expression of SMAD3 protein CTD PMID:18395914 more ... Smad3 Mouse tetrachloromethane increases expression ISO Smad3 (Rattus norvegicus) 6480464 Carbon Tetrachloride results in increased expression of SMAD3 mRNA and Carbon Tetrachloride results in increased expression of SMAD3 protein CTD PMID:15818738 more ... Smad3 Mouse tetrachloromethane multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in increased phosphorylation of SMAD3 protein more ... CTD PMID:15818738 more ... Smad3 Mouse tetrachloromethane increases activity ISO Smad3 (Rattus norvegicus) 6480464 Carbon Tetrachloride results in increased activity of SMAD3 protein CTD PMID:17009398 Smad3 Mouse tetrachloromethane affects response to substance EXP 6480464 SMAD3 protein affects the susceptibility to Carbon Tetrachloride CTD PMID:16382155 Smad3 Mouse tetrachloromethane multiple interactions EXP 6480464 Carbon Tetrachloride inhibits the reaction [HGF protein affects the localization of SMAD3 protein] more ... CTD PMID:18395096 more ... Smad3 Mouse thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of SMAD3 protein modified form CTD PMID:28623179 Smad3 Mouse thioacetamide increases expression ISO Smad3 (Rattus norvegicus) 6480464 Thioacetamide results in increased expression of SMAD3 mRNA CTD PMID:34492290 and PMID:38504479 Smad3 Mouse thioacetamide multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 Curcumin inhibits the reaction [Thioacetamide results in increased phosphorylation of SMAD3 protein] more ... CTD PMID:32278740 more ... Smad3 Mouse thioacetamide increases phosphorylation ISO Smad3 (Rattus norvegicus) 6480464 Thioacetamide results in increased phosphorylation of SMAD3 protein CTD PMID:32278740 and PMID:32718261 Smad3 Mouse thioacetamide multiple interactions EXP 6480464 mirtazapine inhibits the reaction [Thioacetamide results in increased expression of SMAD3 protein modified form] CTD PMID:28623179 Smad3 Mouse thymoquinone multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 thymoquinone inhibits the reaction [Thioacetamide results in increased expression of SMAD3 mRNA] CTD PMID:38504479 Smad3 Mouse titanium dioxide decreases methylation EXP 6480464 titanium dioxide results in decreased methylation of SMAD3 gene CTD PMID:35295148 Smad3 Mouse titanium dioxide increases methylation EXP 6480464 titanium dioxide results in increased methylation of SMAD3 promoter CTD PMID:35295148 Smad3 Mouse trichostatin A affects expression ISO SMAD3 (Homo sapiens) 6480464 trichostatin A affects the expression of SMAD3 mRNA CTD PMID:28542535 Smad3 Mouse triphenyl phosphate affects expression ISO SMAD3 (Homo sapiens) 6480464 triphenyl phosphate affects the expression of SMAD3 mRNA CTD PMID:37042841 Smad3 Mouse troglitazone multiple interactions ISO SMAD3 (Homo sapiens) 6480464 troglitazone inhibits the reaction [TGFB2 protein results in increased phosphorylation of and affects the localization of SMAD3 protein] CTD PMID:18253093 Smad3 Mouse troglitazone decreases expression ISO Smad3 (Rattus norvegicus) 6480464 troglitazone results in decreased expression of SMAD3 mRNA CTD PMID:21515302 Smad3 Mouse tungsten decreases expression EXP 6480464 Tungsten results in decreased expression of SMAD3 mRNA CTD PMID:30912803 Smad3 Mouse ursodeoxycholic acid decreases expression ISO Smad3 (Rattus norvegicus) 6480464 Ursodeoxycholic Acid results in decreased expression of SMAD3 mRNA and Ursodeoxycholic Acid results in decreased expression of SMAD3 protein CTD PMID:19493473 Smad3 Mouse valproic acid increases methylation ISO SMAD3 (Homo sapiens) 6480464 Valproic Acid results in increased methylation of SMAD3 gene CTD PMID:28853863 more ... Smad3 Mouse valproic acid decreases expression ISO SMAD3 (Homo sapiens) 6480464 Valproic Acid results in decreased expression of SMAD3 mRNA and Valproic Acid results in decreased expression of SMAD3 protein CTD PMID:29501571 Smad3 Mouse valsartan multiple interactions ISO Smad3 (Rattus norvegicus) 6480464 Valsartan inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein] CTD PMID:16872305 Smad3 Mouse valsartan decreases expression ISO Smad3 (Rattus norvegicus) 6480464 Valsartan results in decreased expression of SMAD3 protein CTD PMID:15619341 Smad3 Mouse vitamin D multiple interactions ISO SMAD3 (Homo sapiens) 6480464 HRC protein inhibits the reaction [Vitamin D inhibits the reaction [TGFB1 protein results in increased expression of SMAD3 protein]] more ... CTD PMID:33309619 Smad3 Mouse vitamin D multiple interactions EXP 6480464 Vitamin D inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 mRNA] and Vitamin D inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein] CTD PMID:33309619 Smad3 Mouse vitamin E increases expression ISO SMAD3 (Homo sapiens) 6480464 Vitamin E results in increased expression of SMAD3 mRNA CTD PMID:19244175 Smad3 Mouse zearalenone increases expression EXP 6480464 Zearalenone results in increased expression of SMAD3 mRNA CTD PMID:30138655 Smad3 Mouse zearalenone multiple interactions EXP 6480464 [Tamoxifen co-treated with Zearalenone] results in increased expression of SMAD3 mRNA CTD PMID:30138655 Smad3 Mouse zinc atom multiple interactions EXP 6480464 Zinc inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]] more ... CTD PMID:22228435 and PMID:26354774 Smad3 Mouse zinc(0) multiple interactions EXP 6480464 Zinc inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]] more ... CTD PMID:22228435 and PMID:26354774 Smad3 Mouse ziram multiple interactions ISO SMAD3 (Homo sapiens) 6480464 Ziram inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:31652400 Smad3 Mouse zoledronic acid increases expression ISO SMAD3 (Homo sapiens) 6480464 zoledronic acid results in increased expression of SMAD3 mRNA CTD PMID:24714768 Smad3 Mouse zoledronic acid increases phosphorylation ISO SMAD3 (Homo sapiens) 6480464 zoledronic acid results in increased phosphorylation of SMAD3 protein CTD PMID:28871336 Smad3 Mouse zoledronic acid increases phosphorylation ISO Smad3 (Rattus norvegicus) 6480464 zoledronic acid results in increased phosphorylation of SMAD3 protein CTD PMID:28871336 Smad3 Mouse zoledronic acid multiple interactions ISO SMAD3 (Homo sapiens) 6480464 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [zoledronic acid results in increased phosphorylation of SMAD3 protein] CTD PMID:28871336 Smad3 Mouse zoledronic acid increases phosphorylation EXP 6480464 zoledronic acid results in increased phosphorylation of SMAD3 protein CTD PMID:28871336