Smad3 (SMAD family member 3) - Rat Genome Database

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Gene: Smad3 (SMAD family member 3) Mus musculus
Symbol: Smad3
Name: SMAD family member 3
RGD ID: 735647
Description: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; chromatin binding activity; and identical protein binding activity. Involved in several processes, including JNK cascade; negative regulation of osteoblast proliferation; and positive regulation of chondrocyte differentiation. Acts upstream of or within several processes, including embryonic morphogenesis; regulation of DNA-templated transcription; and transmembrane receptor protein serine/threonine kinase signaling pathway. Located in cytoplasm; nucleus; and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and limb. Used to study osteoarthritis. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 3; Lynch syndrome; and pancreatic cancer. Orthologous to human SMAD3 (SMAD family member 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AU022421; MAD homolog 3; mad3; Madh; Madh3; mMad3; mothers against decapentaplegic homolog 3; mothers against DPP homolog 3; Smad 3
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39963,554,048 - 63,665,276 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl963,554,049 - 63,665,276 (-)EnsemblGRCm39 Ensembl
GRCm38963,646,766 - 63,757,994 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl963,646,767 - 63,757,994 (-)EnsemblGRCm38mm10GRCm38
MGSCv37963,494,574 - 63,605,801 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36963,444,773 - 63,556,000 (-)NCBIMGSCv36mm8
Celera960,869,117 - 60,980,879 (-)NCBICelera
Cytogenetic Map9CNCBI
cM Map934.22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(R)-lipoic acid  (EXP)
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
1-O-oleoyl-sn-glycero-3-phosphocholine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-hydroxypropanoic acid  (ISO)
20-HETE  (ISO)
3,4-dihydroxybenzaldehyde  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-Methoxynobiletin  (ISO)
4-hydroxyphenyl retinamide  (EXP)
4-nonylphenol  (ISO)
4-vinylcyclohexene dioxide  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
9-cis-retinoic acid  (EXP)
acetaldehyde  (ISO)
aconitic acid  (EXP,ISO)
acteoside  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-naphthoflavone  (ISO)
AM-251  (ISO)
Ammothamnine  (EXP)
amphetamine  (ISO)
andrographolide  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
asbestos  (ISO)
atrazine  (ISO)
azithromycin  (ISO)
azoxystrobin  (ISO)
bellidifolin  (EXP,ISO)
benazepril  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
benzophenone  (ISO)
betulin  (ISO)
betulinic acid  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP,ISO)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP,ISO)
candesartan  (ISO)
Candesartan cilexetil  (ISO)
cantharidin  (ISO)
carbamazepine  (ISO)
carbofuran  (ISO)
casticin  (ISO)
celastrol  (ISO)
ceruletide  (EXP)
CGP 52608  (ISO)
CGS-21680  (ISO)
chlorpyrifos  (ISO)
cholesterol  (EXP)
choline  (EXP)
chromium(6+)  (ISO)
chrysin  (EXP)
cisplatin  (EXP,ISO)
cocaine  (ISO)
coenzyme Q10  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP,ISO)
corosolic acid  (EXP)
corticosterone  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
cytochalasin D  (ISO)
D-glucose  (ISO)
deguelin  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP)
dimethyl sulfoxide  (ISO)
diminazene diaceturate  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (EXP,ISO)
disulfiram  (ISO)
doxorubicin  (EXP,ISO)
ebselen  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (ISO)
fenthion  (EXP)
ferulic acid  (ISO)
fipronil  (ISO)
fluoranthene  (EXP,ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
galangin  (ISO)
gallic acid  (ISO)
Ganoderic acid A  (EXP)
genistein  (ISO)
geraniol  (ISO)
glucose  (ISO)
glyphosate  (ISO)
heptachlor  (ISO)
hexachlorobenzene  (EXP,ISO)
Honokiol  (EXP,ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
irbesartan  (ISO)
irinotecan  (ISO)
isoprenaline  (ISO)
isorhamnetin  (ISO)
L-methionine  (EXP)
lead diacetate  (ISO)
leptomycin B  (EXP)
linoleic acid  (EXP)
lipoic acid  (EXP)
lipopolysaccharide  (EXP)
lithocholic acid  (EXP)
LY-2157299  (ISO)
lycopene  (ISO)
melphalan  (ISO)
menadione  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methoxychlor  (ISO)
Methylazoxymethanol acetate  (ISO)
methylmercury chloride  (EXP,ISO)
methylparaben  (ISO)
mirtazapine  (EXP)
monocrotaline  (ISO)
Muraglitazar  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
naringin  (ISO)
niclosamide  (EXP,ISO)
nicotine  (EXP,ISO)
nitric oxide  (ISO)
nitrofen  (EXP)
Nonylphenol  (ISO)
ochratoxin A  (EXP,ISO)
oridonin  (ISO)
osthole  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
patulin  (ISO)
perfluorohexanesulfonic acid  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perindopril  (ISO)
phenylarsine oxide  (ISO)
phenylmercury acetate  (ISO)
phloroglucinol  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
Phyllanthin  (EXP)
picoxystrobin  (ISO)
picrotoxin  (ISO)
pinostrobin  (ISO)
pirinixic acid  (EXP)
platycodin D  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
quercetin  (EXP,ISO)
quercitrin  (ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
salvianolic acid B  (EXP,ISO)
SB 203580  (ISO)
SB 431542  (EXP,ISO)
SCH 23390  (ISO)
serpentine asbestos  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
simvastatin  (EXP,ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP)
sorafenib  (EXP)
sphingosine 1-phosphate  (ISO)
streptozocin  (EXP,ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP,ISO)
Tanshinone I  (ISO)
tauro-beta-muricholic acid  (EXP)
taurochenodeoxycholic acid  (EXP)
taurolithocholic acid  (EXP)
tauroursodeoxycholic acid  (EXP)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP,ISO)
trichostatin A  (ISO)
troglitazone  (ISO)
tungsten  (EXP)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
vitamin D  (EXP,ISO)
vitamin E  (ISO)
zearalenone  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)
ziram  (ISO)
zoledronic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  (ISO)
activin receptor signaling pathway  (IBA,ISO,NAS)
adrenal gland development  (ISO)
anatomical structure morphogenesis  (IBA)
apoptotic process  (IMP)
cell differentiation  (IBA)
cell population proliferation  (IGI)
cell-cell junction organization  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to virus  (IDA)
developmental growth  (IGI)
embryonic cranial skeleton morphogenesis  (IGI)
embryonic foregut morphogenesis  (IGI)
embryonic pattern specification  (IGI)
endoderm development  (IGI)
extrinsic apoptotic signaling pathway  (ISO)
gastrulation  (IGI)
heart looping  (IGI)
immune response  (ISO)
immune system development  (IGI)
in utero embryonic development  (IGI)
JNK cascade  (IMP)
lens fiber cell differentiation  (IMP)
liver development  (IGI)
MAPK cascade  (IMP)
mesoderm formation  (IMP)
negative regulation of apoptotic process  (ISO)
negative regulation of cardiac muscle hypertrophy in response to stress  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cytosolic calcium ion concentration  (ISO)
negative regulation of fat cell differentiation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of inflammatory response  (IMP)
negative regulation of lung blood pressure  (ISO)
negative regulation of miRNA transcription  (ISO)
negative regulation of osteoblast differentiation  (IGI)
negative regulation of osteoblast proliferation  (IMP)
negative regulation of protein catabolic process  (ISO)
negative regulation of transcription by RNA polymerase II  (IDA,ISO)
negative regulation of wound healing  (IMP)
nodal signaling pathway  (ISO)
osteoblast development  (IGI)
osteoblast differentiation  (IMP)
paraxial mesoderm morphogenesis  (IMP)
pericardium development  (IGI)
positive regulation of alkaline phosphatase activity  (ISO)
positive regulation of bone mineralization  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of chondrocyte differentiation  (IMP)
positive regulation of DNA-templated transcription  (IDA,ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of extracellular matrix assembly  (ISO)
positive regulation of focal adhesion assembly  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of miRNA transcription  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of positive chemotaxis  (ISO)
positive regulation of stress fiber assembly  (ISO)
positive regulation of transcription by RNA polymerase II  (IBA,IDA,IGI,IMP,ISO)
positive regulation of transforming growth factor beta3 production  (ISO)
protein stabilization  (ISO)
regulation of DNA-templated transcription  (ISO,NAS)
regulation of epithelial cell proliferation  (IMP)
regulation of immune response  (IMP)
regulation of striated muscle tissue development  (IDA)
regulation of transcription by RNA polymerase II  (ISO)
regulation of transforming growth factor beta receptor signaling pathway  (IDA,ISO)
regulation of transforming growth factor beta2 production  (ISO)
response to angiotensin  (ISO)
response to hypoxia  (ISO)
response to transforming growth factor beta  (IGI)
signal transduction involved in regulation of gene expression  (ISO)
skeletal system development  (IGI)
SMAD protein signal transduction  (IBA,IGI,ISO)
somitogenesis  (IMP)
T cell activation  (IMP)
thyroid gland development  (IGI)
transdifferentiation  (ISO)
transforming growth factor beta receptor signaling pathway  (IBA,IDA,IMP,ISO,NAS)
ureteric bud development  (IEP)

Cellular Component

Molecular Function
beta-catenin binding  (ISO)
bHLH transcription factor binding  (ISO)
chromatin binding  (IDA)
chromatin DNA binding  (IDA)
cis-regulatory region sequence-specific DNA binding  (ISO)
co-SMAD binding  (ISO)
collagen binding  (IPI)
DEAD/H-box RNA helicase binding  (ISO)
DNA binding  (IDA,ISO)
DNA-binding transcription activator activity, RNA polymerase II-specific  (IPI,ISO)
DNA-binding transcription factor activity  (IDA,ISO)
DNA-binding transcription factor activity, RNA polymerase II-specific  (IBA,ISO)
DNA-binding transcription factor binding  (ISO)
DNA-binding transcription repressor activity  (ISO)
double-stranded DNA binding  (IDA)
enzyme binding  (ISO)
I-SMAD binding  (IBA)
identical protein binding  (IPI,ISO)
metal ion binding  (IEA)
nuclear glucocorticoid receptor binding  (ISO)
nuclear mineralocorticoid receptor binding  (ISO)
nuclear receptor binding  (ISO)
phosphatase binding  (ISO)
promoter-specific chromatin binding  (IDA)
protein binding  (IPI)
protein homodimerization activity  (ISO)
protein kinase binding  (ISO)
R-SMAD binding  (ISO)
RNA polymerase II cis-regulatory region sequence-specific DNA binding  (IBA,ISO)
RNA polymerase II transcription regulatory region sequence-specific DNA binding  (IDA,ISO)
RNA polymerase II-specific DNA-binding transcription factor binding  (IPI,ISO)
sequence-specific DNA binding  (ISO)
sterol response element binding  (ISO)
transcription cis-regulatory region binding  (ISO)
transcription coactivator binding  (ISO)
transcription corepressor binding  (ISO)
transcription factor binding  (ISO)
transforming growth factor beta receptor binding  (ISO)
ubiquitin binding  (ISO)
ubiquitin protein ligase binding  (ISO)
zinc ion binding  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal anterior definitive endoderm morphology  (IAGP)
abnormal articular cartilage morphology  (IAGP)
abnormal B cell proliferation  (IAGP)
abnormal carpal bone morphology  (IAGP)
abnormal cartilage morphology  (IAGP)
abnormal CD4-positive T cell differentiation  (IAGP)
abnormal cell morphology  (IAGP)
abnormal cell physiology  (IAGP)
abnormal cell proliferation  (IAGP)
abnormal chondrocyte morphology  (IAGP)
abnormal circulating interleukin-6 level  (IAGP)
abnormal colon morphology  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal cumulus expansion  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal developmental patterning  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal endoderm development  (IAGP)
abnormal epiphyseal plate morphology  (IAGP)
abnormal fertility/fecundity  (IAGP)
abnormal foregut morphology  (IAGP)
abnormal forelimb morphology  (IAGP)
abnormal gastrulation  (IAGP)
abnormal heart development  (IAGP)
abnormal heart looping  (IAGP)
abnormal hepatic cord morphology  (IAGP)
abnormal hepatoblast migration  (IAGP)
abnormal hepatocyte physiology  (IAGP)
abnormal immune system morphology  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal joint morphology  (IAGP)
abnormal keratinocyte physiology  (IAGP)
abnormal kidney epithelium morphology  (IAGP)
abnormal leukocyte physiology  (IAGP)
abnormal liver morphology  (IAGP)
abnormal locomotor behavior  (IAGP)
abnormal Meckel's cartilage morphology  (IAGP)
abnormal mesangial matrix morphology  (IAGP)
abnormal mesendoderm development  (IAGP)
abnormal ovarian follicle morphology  (IAGP)
abnormal ovarian folliculogenesis  (IAGP)
abnormal pericardial cavity morphology  (IAGP)
abnormal physiological response to xenobiotic  (IAGP)
abnormal posture  (IAGP)
abnormal prechordal plate morphology  (IAGP)
abnormal primitive streak formation  (IAGP)
abnormal rectum morphology  (IAGP)
abnormal renal glomerulus basement membrane thickness  (IAGP)
abnormal rib morphology  (IAGP)
abnormal skeleton physiology  (IAGP)
abnormal somite development  (IAGP)
abnormal sternum morphology  (IAGP)
abnormal synovial joint capsule morphology  (IAGP)
abnormal T cell activation  (IAGP)
abnormal T cell physiology  (IAGP)
abnormal T cell proliferation  (IAGP)
abnormal talus morphology  (IAGP)
abnormal tarsal bone morphology  (IAGP)
abnormal thoracic cage morphology  (IAGP)
abnormal thymus involution  (IAGP)
abnormal vascular wound healing  (IAGP)
absent foregut  (IAGP)
calcified joint  (IAGP)
colitis  (IAGP)
colon polyps  (IAGP)
cyclopia  (IAGP)
decreased apoptosis  (IAGP)
decreased B cell apoptosis  (IAGP)
decreased blood urea nitrogen level  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral density  (IAGP)
decreased circulating alkaline phosphatase level  (IEA)
decreased circulating creatinine level  (IAGP)
decreased hepatocyte proliferation  (IAGP)
decreased interleukin-6 secretion  (IAGP)
decreased kidney weight  (IAGP)
decreased litter size  (IAGP)
decreased oocyte number  (IAGP)
decreased primary ovarian follicle number  (IAGP)
decreased renal tubule apoptosis  (IAGP)
decreased secondary ovarian follicle number  (IAGP)
decreased susceptibility to injury  (IAGP)
decreased susceptibility to kidney reperfusion injury  (IAGP)
decreased tertiary ovarian follicle number  (IAGP)
delayed hepatic development  (IAGP)
dilated liver sinusoidal space  (IAGP)
distended abdomen  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
enhanced wound healing  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged mesenteric lymph nodes  (IAGP)
extramedullary hematopoiesis  (IAGP)
fused somites  (IAGP)
holoprosencephaly  (IAGP)
impaired neutrophil chemotaxis  (IAGP)
impaired ovarian folliculogenesis  (IAGP)
increased adenoma incidence  (IAGP)
increased adrenal gland tumor incidence  (IAGP)
increased atretic ovarian follicle number  (IAGP)
increased body weight  (IAGP)
increased circulating creatinine level  (IAGP)
increased circulating follicle stimulating hormone level  (IAGP)
increased circulating luteinizing hormone level  (IAGP)
increased colon adenocarcinoma incidence  (IAGP)
increased erythrocyte cell number  (IAGP)
increased fetal size  (IAGP)
increased inflammatory response  (IAGP)
increased intestinal adenocarcinoma incidence  (IAGP)
increased leukocyte cell number  (IAGP)
increased metastatic potential  (IAGP)
increased monocyte cell number  (IAGP)
increased neutrophil cell number  (IAGP)
increased ovary tumor incidence  (IAGP)
increased physiological sensitivity to xenobiotic  (IAGP)
increased primordial ovarian follicle number  (IAGP)
increased Sertoli cell number  (IAGP)
increased susceptibility to kidney reperfusion injury  (IAGP)
increased width of hypertrophic chondrocyte zone  (IAGP)
intestinal obstruction  (IAGP)
kyphoscoliosis  (IAGP)
kyphosis  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lethargy  (IAGP)
liver hypoplasia  (IAGP)
osteoarthritis  (IAGP)
pancreas inflammation  (IAGP)
premature death  (IAGP)
premature ovarian failure  (IAGP)
preweaning lethality, complete penetrance  (IEA)
rectal prolapse  (IAGP)
reduced female fertility  (IAGP)
renal interstitial fibrosis  (IAGP)
renal tubular necrosis  (IAGP)
rostral body truncation  (IAGP)
ruffled hair  (IAGP)
small intestinal inflammation  (IAGP)
small liver  (IAGP)
small spleen  (IAGP)
small thyroid gland  (IAGP)
spleen hypoplasia  (IAGP)
stomach inflammation  (IAGP)
thymus hypoplasia  (IAGP)
tubulointerstitial nephritis  (IAGP)

References - curated
# Reference Title Reference Citation
1. Cardioprotective role of growth/differentiation factor 1 in post-infarction left ventricular remodelling and dysfunction. Bao MW, etal., J Pathol. 2015 Jul;236(3):360-72. doi: 10.1002/path.4523. Epub 2015 Mar 30.
2. Ovarian follicle populations of the rat express TGF-beta signalling pathways. Drummond AE, etal., Mol Cell Endocrinol. 2003 Apr 28;202(1-2):53-7.
3. Bone marrow derived-mesenchymal stem cells downregulate IL17A dependent IL6/STAT3 signaling pathway in CCl4-induced rat liver fibrosis. Farouk S, etal., PLoS One. 2018 Oct 22;13(10):e0206130. doi: 10.1371/journal.pone.0206130. eCollection 2018.
4. Tumor suppression effects of bilberry extracts and enzymatically modified isoquercitrin in early preneoplastic liver cell lesions induced by piperonyl butoxide promotion in a two-stage rat hepatocarcinogenesis model. Hara S, etal., Exp Toxicol Pathol. 2014 Aug;66(5-6):225-34. doi: 10.1016/j.etp.2014.02.002. Epub 2014 Mar 26.
5. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Jones S, etal., Science. 2008 Sep 26;321(5897):1801-6. Epub 2008 Sep 4.
6. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
7. Lefty1 Ameliorates Post-infarction Fibrosis by Suppressing p-Smad2 and p-ERK1/2 Signaling Pathways. Li CY, etal., J Cardiovasc Transl Res. 2021 Aug;14(4):636-646. doi: 10.1007/s12265-020-10089-2. Epub 2021 Jan 6.
8. Requirement of Smad3 and CREB-1 in mediating transforming growth factor-beta (TGF beta) induction of TGF beta 3 secretion. Liu G, etal., J Biol Chem. 2006 Oct 6;281(40):29479-90. Epub 2006 Aug 4.
9. cAMP inhibits transforming growth factor-beta-stimulated collagen synthesis via inhibition of extracellular signal-regulated kinase 1/2 and Smad signaling in cardiac fibroblasts. Liu X, etal., Mol Pharmacol. 2006 Dec;70(6):1992-2003. Epub 2006 Sep 7.
10. Smad3 is overexpressed in advanced human prostate cancer and necessary for progressive growth of prostate cancer cells in nude mice. Lu S, etal., Clin Cancer Res. 2007 Oct 1;13(19):5692-702.
11. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
12. MGDs mouse GO annotations MGD data from the GO Consortium
14. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
15. Altered expression of Smad family members in injured motor neurons of rat. Okuyama N, etal., Brain Res. 2007 Feb 9;1132(1):36-41. Epub 2006 Dec 12.
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. Expression and intracellular localization of Smad proteins in human endometrial cancer. Piestrzeniewicz-Ulanska D, etal., Oncol Rep. 2003 Sep-Oct;10(5):1539-44.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
20. Mouse MP Annotation Import Pipeline RGD automated import pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Mutation analysis of SMAD2, SMAD3, and SMAD4 genes in hereditary non-polyposis colorectal. Roth S, etal., J Med Genet. 2000 Apr;37(4):298-300.
24. FOSL2 positively regulates TGF-beta1 signalling in non-small cell lung cancer. Wang J, etal., PLoS One. 2014 Nov 6;9(11):e112150. doi: 10.1371/journal.pone.0112150. eCollection 2014.
25. Treatment with cardiotonic pills(®) after ischemia-reperfusion ameliorates myocardial fibrosis in rats. Wei XH, etal., Microcirculation. 2013 Jan;20(1):17-29. doi: 10.1111/micc.12002.
26. TGF-beta signaling alterations and susceptibility to colorectal cancer. Xu Y and Pasche B, Hum Mol Genet. 2007 Apr 15;16 Spec No 1:R14-20.
27. Lefty-1 inhibits renal epithelial-mesenchymal transition by antagonizing the TGF-β/Smad signaling pathway. Zhang L, etal., J Mol Histol. 2020 Feb;51(1):77-87. doi: 10.1007/s10735-020-09859-8. Epub 2020 Feb 17.
28. Negative immune factors might predominate local tumor immune status and promote carcinogenesis in cervical carcinoma. Zhao M, etal., Virol J. 2017 Jan 13;14(1):5. doi: 10.1186/s12985-016-0670-8.
Additional References at PubMed
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PMID:11438667   PMID:11585338   PMID:11711431   PMID:11839555   PMID:11850197   PMID:11891202   PMID:11906909   PMID:11937490   PMID:11959813   PMID:11984875   PMID:12069494   PMID:12086850  
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Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39963,554,048 - 63,665,276 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl963,554,049 - 63,665,276 (-)EnsemblGRCm39 Ensembl
GRCm38963,646,766 - 63,757,994 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl963,646,767 - 63,757,994 (-)EnsemblGRCm38mm10GRCm38
MGSCv37963,494,574 - 63,605,801 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36963,444,773 - 63,556,000 (-)NCBIMGSCv36mm8
Celera960,869,117 - 60,980,879 (-)NCBICelera
Cytogenetic Map9CNCBI
cM Map934.22NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381567,065,602 - 67,195,169 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1567,063,763 - 67,195,173 (+)EnsemblGRCh38hg38GRCh38
GRCh371567,357,940 - 67,487,507 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361565,145,249 - 65,274,587 (+)NCBINCBI36Build 36hg18NCBI36
Build 341565,145,248 - 65,274,586NCBI
Celera1544,246,635 - 44,375,039 (+)NCBICelera
Cytogenetic Map15q22.33NCBI
HuRef1544,193,465 - 44,321,904 (+)NCBIHuRef
CHM1_11567,476,260 - 67,605,488 (+)NCBICHM1_1
T2T-CHM13v2.01564,885,345 - 65,017,070 (+)NCBIT2T-CHM13v2.0
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8873,022,204 - 73,132,324 (-)NCBIGRCr8
mRatBN7.2864,126,829 - 64,236,960 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl864,110,039 - 64,236,960 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx869,641,910 - 69,752,073 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0867,914,370 - 68,024,539 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0865,784,499 - 65,894,665 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0868,569,530 - 68,678,349 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl868,569,530 - 68,678,349 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0868,290,927 - 68,397,727 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4867,803,909 - 67,952,056 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1867,822,964 - 67,971,110 (-)NCBI
Celera863,537,497 - 63,647,062 (-)NCBICelera
Cytogenetic Map8q24NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554508,747,651 - 8,842,136 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554508,747,651 - 8,842,003 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21656,319,096 - 56,448,455 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11560,491,695 - 60,621,061 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01546,013,764 - 46,143,126 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11564,284,949 - 64,414,185 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1564,284,949 - 64,414,185 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.13031,246,313 - 31,360,098 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3031,245,657 - 31,363,337 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3031,175,971 - 31,289,442 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03031,444,224 - 31,557,937 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3031,444,224 - 31,561,176 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13031,371,657 - 31,485,227 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03031,431,846 - 31,545,247 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03031,673,713 - 31,787,293 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024408640109,232,767 - 109,341,735 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647127,080,575 - 27,189,793 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647127,080,662 - 27,185,861 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1164,998,103 - 165,124,449 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11164,998,457 - 165,124,455 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21182,902,348 - 182,926,370 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12616,319,959 - 16,446,472 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2616,320,933 - 16,446,527 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048125,021,354 - 125,151,320 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247815,795,652 - 5,890,371 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247815,795,652 - 5,890,047 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Smad3
3614 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2427
Count of miRNA genes:822
Interacting mature miRNAs:1111
Transcripts:ENSMUST00000034973, ENSMUST00000133108, ENSMUST00000137065, ENSMUST00000137713, ENSMUST00000154323
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13208563Bmiq8_mbody mass index QTL 8 (mouse)92491129668907282Mouse
1301365Ap5q_malcohol preference 5 QTL (mouse)Not determined93005316464053277Mouse
1357746Vtbt7_mvertebral trabecular bone trait 7 (mouse)Not determined93073991564740021Mouse
1302180Actd4_mactivity-distance traveled 4 (mouse)Not determined93243456366434857Mouse
4141148Cq5_mcholesterol QTL 5 (mouse)Not determined93245242166452546Mouse
1301692Hts_mhypothermia sensitivity (mouse)Not determined93251117266511421Mouse
4141323Ptnu3_mproteinuria 3 (mouse)Not determined93288970266889836Mouse
1357709Si5lq3_mserum IGFBP-5 level QTL 3 (mouse)Not determined93311102567111140Mouse
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93397884073439255Mouse
1301252Etohc3_methanol consumption 3 (mouse)Not determined93503447869034599Mouse
1301972Cocrb8_mcocaine related behavior 8 (mouse)Not determined93503447869034599Mouse
1558968Tbdr1_mbody temperature response to dietary restriction, QTL 1 (mouse)Not determined93503447869034599Mouse
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93730619798701707Mouse
10043971Obq32_mobesity QTL 32 (mouse)Not determined93781952871819528Mouse
12790986Pcho9_mplasma cholesterol 9 (mouse)93809957572099575Mouse
12790992Arlsq1_maortic root lesion size QTL 1 (mouse)93809957572099575Mouse
12791002Arlsq2_maortic root lesion size QTL 2 (mouse)93809957572099575Mouse
12738449Spcq2_msperm count QTL 2 (mouse)93939988573399885Mouse
4141071Ath29_matherosclerosis 29 (mouse)Not determined94041959474607925Mouse
1301702Brm1_mbrachyury modifier 1 (mouse)Not determined94080504774805204Mouse
1301558Stheal8_msoft tissue heal 8 (mouse)Not determined94348071477480860Mouse
10045639Heal28_mwound healing/regeneration 28 (mouse)Not determined94348071477480860Mouse
1301435Trigq1_mtriglyceride QTL 1 (mouse)Not determined94442817478428262Mouse
4141572Ntta3_mneurotensin transcript abundance 3 (mouse)Not determined4659767165831177Mouse
1300563Pgia5_mproteoglycan induced arthritis 5 (mouse)Not determined94883105682831177Mouse
1300716Cd4ts4_mCD4 T cell subset 4 (mouse)Not determined94883105682831177Mouse
1301049El4_mepilepsy 4 (mouse)Not determined94942029867151448Mouse
4141224Dxmod_mdoxorubicin nephropathy modifier (mouse)Not determined49452421101406120Mouse
14746993Manh66_mmandible shape 66 (mouse)94981404883814048Mouse
1301184Bdln4_mbody length 4 (mouse)Not determined95015132084151448Mouse
1301241Renf1_mrenal failure 1 (mouse)Not determined95203447899792481Mouse
13525008Hrtiq1_mheart rate time index, QTL 1 (mouse)95242609868556008Mouse
12790990Tgl7_mtriglyceride 7 (mouse)95455996088559960Mouse
10043877Adip21_madiposity 21 (mouse)Not determined95643910890439255Mouse
1301965Vmbic5_mventral midbrain iron content 5 (mouse)Not determined95759149265831177Mouse
1301549Bbaa9_mB.burgdorferi-associated arthritis 9 (mouse)Not determined95780504771481754Mouse
4141676Neogq1_mneonatal growth QTL 1 (mouse)Not determined95780504786121973Mouse
13525007Lfhrvq1_mlow frequency time index heart rate varaiblity, QTL 1 (mouse)95878431868556008Mouse
1301803Stheal9_msoft tissue heal 9 (mouse)Not determined95902438793024534Mouse
1301172Fembrs6_mfemur breaking strength 6 (mouse)Not determined95902438793024534Mouse
1301456Adip5_madiposity 5 (mouse)Not determined95936994693370128Mouse
1300848Skull13_mskull morphology 13 (mouse)Not determined95936994693370128Mouse
5491195Mobq8_mmultigenic obesity QTL 8 (mouse)Not determined95936994693370128Mouse
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959897283109089068Mouse
1301611Lrnx3_mlearning contextual 3 (mouse)Not determined96214976796149881Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63239711120191934Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63239711120191934Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963239711120191934Mouse

Markers in Region
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9DUniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38963,646,923 - 63,647,074UniSTSGRCm38
MGSCv37963,494,730 - 63,494,881UniSTSGRCm37
Celera960,869,273 - 60,869,424UniSTS
Cytogenetic Map9DUniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38963,646,814 - 63,646,950UniSTSGRCm38
MGSCv37963,494,621 - 63,494,757UniSTSGRCm37
Celera960,869,164 - 60,869,300UniSTS
Cytogenetic Map9DUniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9DUniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9DUniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38963,667,786 - 63,667,916UniSTSGRCm38
MGSCv37963,515,593 - 63,515,723UniSTSGRCm37
Celera960,890,136 - 60,890,266UniSTS
Cytogenetic Map9DUniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38963,757,484 - 63,757,678UniSTSGRCm38
MGSCv37963,605,291 - 63,605,485UniSTSGRCm37
Celera960,980,370 - 60,980,564UniSTS
Cytogenetic Map9DUniSTS
Cytogenetic Map9CUniSTS
cM Map9 UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9DUniSTS
cM Map9 UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9DUniSTS



Nucleotide Sequences
RefSeq Transcripts NM_016769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006510819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006510821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB008192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC158515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF016189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK030926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK041743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK048626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK083158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC022904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC025486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000034973   ⟹   ENSMUSP00000034973
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl963,554,049 - 63,665,276 (-)Ensembl
GRCm38.p6 Ensembl963,646,767 - 63,757,994 (-)Ensembl
RefSeq Acc Id: ENSMUST00000133108   ⟹   ENSMUSP00000122217
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl963,573,430 - 63,658,359 (-)Ensembl
GRCm38.p6 Ensembl963,666,148 - 63,751,077 (-)Ensembl
RefSeq Acc Id: ENSMUST00000137065
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl963,575,095 - 63,650,547 (-)Ensembl
GRCm38.p6 Ensembl963,667,813 - 63,743,265 (-)Ensembl
RefSeq Acc Id: ENSMUST00000137713   ⟹   ENSMUSP00000121671
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl963,562,053 - 63,573,829 (-)Ensembl
GRCm38.p6 Ensembl963,654,771 - 63,666,547 (-)Ensembl
RefSeq Acc Id: ENSMUST00000154323   ⟹   ENSMUSP00000116790
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl963,562,081 - 63,619,251 (-)Ensembl
GRCm38.p6 Ensembl963,654,799 - 63,711,969 (-)Ensembl
RefSeq Acc Id: NM_016769   ⟹   NP_058049
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm39963,554,049 - 63,665,276 (-)NCBI
GRCm38963,646,767 - 63,757,994 (-)NCBI
MGSCv37963,494,574 - 63,605,801 (-)RGD
Celera960,869,117 - 60,980,879 (-)RGD
RefSeq Acc Id: XM_006510819   ⟹   XP_006510882
Mouse AssemblyChrPosition (strand)Source
GRCm39963,554,048 - 63,619,505 (-)NCBI
GRCm38963,646,766 - 63,712,259 (-)NCBI
RefSeq Acc Id: XM_006510821   ⟹   XP_006510884
Mouse AssemblyChrPosition (strand)Source
GRCm39963,554,048 - 63,574,172 (-)NCBI
GRCm38963,646,766 - 63,666,900 (-)NCBI
Protein Sequences