Gdf15 (growth differentiation factor 15) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Gdf15 (growth differentiation factor 15) Mus musculus
Analyze
Symbol: Gdf15
Name: growth differentiation factor 15
RGD ID: 735622
MGI Page MGI
Description: Enables cytokine activity; hormone activity; and protein homodimerization activity. Involved in several processes, including GDF15-GFRAL signaling pathway; reduction of food intake in response to dietary excess; and regulation of signal transduction. Acts upstream of or within positive regulation of myoblast fusion. Located in extracellular region. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and liver. Orthologous to human GDF15 (growth differentiation factor 15).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: GDF-15; growth/differentiation factor 15; macrophage inhibiting cytokine-1; macrophage inhibitory cytokine 1; MIC-; MIC-1; NAG; NAG-1; SBF
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,082,043 - 71,085,106 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl871,082,043 - 71,085,106 (-)EnsemblGRCm39 Ensembl
GRCm38870,629,393 - 70,632,470 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,629,393 - 70,632,456 (-)EnsemblGRCm38mm10GRCm38
MGSCv37873,153,293 - 73,155,534 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36873,558,382 - 73,561,082 (-)NCBIMGSCv36mm8
Celera873,186,175 - 73,188,416 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-taxifolin  (ISO)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (EXP)
(S)-colchicine  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dichloroindophenol  (ISO)
2-acetamidofluorene  (EXP)
2-butoxyethanol  (EXP)
2-nitrofluorene  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3'-diindolylmethane  (ISO)
3,4-dichloroaniline  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-amino-2,6-dinitrotoluene  (ISO)
4-Hydroxybenzophenone  (EXP)
4-hydroxyphenyl retinamide  (EXP,ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-bromo-2'-deoxyuridine  (EXP)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
[6]-Shogaol  (ISO)
aceclofenac  (EXP,ISO)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
adefovir pivoxil  (ISO)
adenine  (ISO)
aflatoxin B1  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
amphibole asbestos  (ISO)
amphotericin B  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
arecoline  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
Aurin  (ISO)
azathioprine  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
Benzo[ghi]perylene  (EXP)
Benzo[k]fluoranthene  (EXP)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
bromoacetate  (ISO)
bromobenzene  (ISO)
buta-1,3-diene  (EXP)
butan-1-ol  (ISO)
butanal  (ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
camptothecin  (ISO)
cannabidiol  (EXP,ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP,ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
cefaloridine  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
chlordecone  (EXP)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
chloroprene  (EXP)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (EXP,ISO)
chrysene  (EXP)
cidofovir anhydrous  (ISO)
ciguatoxin CTX1B  (EXP)
cisplatin  (EXP,ISO)
clodronic acid  (ISO)
clofibrate  (EXP)
clothianidin  (ISO)
clozapine  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corosolic acid  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cryptolepine  (ISO)
CU-O LINKAGE  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
daunorubicin  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
dexamethasone  (EXP,ISO)
diallyl disulfide  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (EXP)
dichromium trioxide  (ISO)
diclofenac  (EXP,ISO)
dicrotophos  (ISO)
Didecyldimethylammonium  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (ISO)
dihydroxyacetone  (ISO)
dimethylarsinic acid  (EXP)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
diquat  (EXP)
disodium selenite  (ISO)
diuron  (ISO)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP)
erlotinib hydrochloride  (ISO)
esketamine  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenamidone  (EXP)
fenofibrate  (ISO)
fenpyroximate  (ISO)
flurbiprofen  (ISO)
flutamide  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
furan  (EXP,ISO)
gedunin  (ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
gingerol  (ISO)
glyphosate  (ISO)
graphene oxide  (EXP)
graphite  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroxyurea  (ISO)
ibuprofen  (ISO)
ifosfamide  (ISO)
imidacloprid  (ISO)
imidazopyrazole  (ISO)
indole-3-methanol  (ISO)
indometacin  (EXP,ISO)
inulin  (EXP)
irinotecan  (ISO)
iron dichloride  (ISO)
isotretinoin  (ISO)
ivermectin  (EXP,ISO)
jaspamide  (ISO)
Lasiocarpine  (ISO)
latrunculin B  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
lidocaine  (ISO)
lipopolysaccharide  (EXP,ISO)
lucanthone  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
metacetamol  (EXP)
metformin  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (EXP)
methylmercury chloride  (ISO)
methylparaben  (ISO)
mitomycin C  (ISO)
Mitotane  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N(4)-hydroxycytidine  (EXP)
N-acetyl-L-cysteine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methylformamide  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (ISO)
N-Nitrosopyrrolidine  (ISO)
naphthalene  (EXP,ISO)
nevirapine  (EXP)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
NS-398  (ISO)
Nutlin-3  (ISO)
O-methyleugenol  (ISO)
Octicizer  (EXP)
octreotide  (ISO)
oxaliplatin  (ISO)
ozone  (EXP)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentanal  (ISO)
perfluorodecanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
phenobarbital  (EXP)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
phloroglucinol  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (EXP)
picoxystrobin  (ISO)
pifithrin-?  (ISO)
pinosylvin  (ISO)
pioglitazone  (EXP)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
platycodin D  (ISO)
potassium dichromate  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
prostaglandin J2  (ISO)
pterostilbene  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
Ro 31-8220  (ISO)
rotenone  (ISO)
rottlerin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
SB 203580  (ISO)
SB 431542  (ISO)
SCH 23390  (ISO)
Securinine  (ISO)
serpentine asbestos  (ISO)
silibinin  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sulindac  (EXP,ISO)
sulindac sulfide  (EXP,ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (EXP,ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
tetraphene  (EXP)
thapsigargin  (ISO)
theophylline  (ISO)
thiabendazole  (ISO)
thifluzamide  (ISO)
thioacetamide  (ISO)
thiostrepton  (ISO)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (ISO)
trans-pinosylvin  (ISO)
tributyl phosphate  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
triptonide  (EXP)
tris(2-butoxyethyl) phosphate  (EXP)
tris(2-chloroethyl) phosphate  (EXP)
troglitazone  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
wortmannin  (ISO)
zinc atom  (ISO)
zinc oxide  (ISO)
zinc pyrithione  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Characterization of the rat, mouse, and human genes of growth/differentiation factor-15/macrophage inhibiting cytokine-1 (GDF-15/MIC-1). Bottner M, etal., Gene 1999 Sep 3;237(1):105-11.
2. Hepcidin and GDF15 in anemia of multiple myeloma. Mei S, etal., Int J Hematol. 2014 Sep;100(3):266-73. doi: 10.1007/s12185-014-1626-7. Epub 2014 Jul 23.
3. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10779363   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:12514175   PMID:14610273   PMID:15342483   PMID:15897808   PMID:16141072   PMID:16141073  
PMID:16154591   PMID:16397141   PMID:16397142   PMID:16602821   PMID:17286605   PMID:17982462   PMID:18210153   PMID:18799693   PMID:19074584   PMID:19375854   PMID:19401523   PMID:19864576  
PMID:20431030   PMID:20534737   PMID:21128084   PMID:21242297   PMID:21267068   PMID:21516086   PMID:21677750   PMID:21873635   PMID:22190281   PMID:22386250   PMID:22514681   PMID:22675198  
PMID:22952779   PMID:23231375   PMID:23262134   PMID:23316317   PMID:23468844   PMID:23503457   PMID:23640134   PMID:23791946   PMID:23800095   PMID:23836903   PMID:23844157   PMID:23986522  
PMID:24194600   PMID:24236027   PMID:24496615   PMID:24504814   PMID:24531647   PMID:24952961   PMID:25180886   PMID:25239873   PMID:25695521   PMID:25948320   PMID:26077927   PMID:26154268  
PMID:26657772   PMID:26733415   PMID:27115420   PMID:27120339   PMID:27235139   PMID:27353765   PMID:27421482   PMID:27626380   PMID:27986797   PMID:28081177   PMID:28223503   PMID:28432312  
PMID:28572090   PMID:28734801   PMID:28771943   PMID:28846097   PMID:28847729   PMID:28874416   PMID:28953886   PMID:29026214   PMID:29046435   PMID:29222479   PMID:29482168   PMID:29491220  
PMID:29674655   PMID:29717162   PMID:29724997   PMID:29750874   PMID:30070999   PMID:30554141   PMID:30635935   PMID:30685336   PMID:30755731   PMID:31097328   PMID:31152154   PMID:31155355  
PMID:31232176   PMID:31304450   PMID:31324641   PMID:31411815   PMID:31506384   PMID:31875646   PMID:31882966   PMID:31925461   PMID:32026535   PMID:32034106   PMID:32228886   PMID:32424099  
PMID:32464196   PMID:32492819   PMID:32691494   PMID:32694673   PMID:32723474   PMID:32929274   PMID:32977372   PMID:33003626   PMID:33069782   PMID:33151561   PMID:33207247   PMID:33337559  
PMID:33346004   PMID:33589633   PMID:33593916   PMID:33718833   PMID:33758420   PMID:34380027   PMID:34526227   PMID:34571994   PMID:34763008   PMID:34846534   PMID:34920697   PMID:34935522  
PMID:35202387   PMID:35290443   PMID:35385705   PMID:35420978   PMID:35443244   PMID:35472437   PMID:35504134   PMID:35597591   PMID:35614212   PMID:35868568   PMID:36001956   PMID:36046792  
PMID:36049542   PMID:36064109   PMID:36427806   PMID:36465107   PMID:36631664   PMID:36640326   PMID:36912475   PMID:37217020   PMID:37224335   PMID:37270567   PMID:37380764   PMID:37433299  
PMID:37473755   PMID:37499753   PMID:37584611   PMID:37766993   PMID:37818094   PMID:37819027   PMID:37847913   PMID:38013040   PMID:38056430   PMID:38092039   PMID:38176644   PMID:38253650  
PMID:38301257   PMID:38355793   PMID:38366596   PMID:38607075   PMID:38719753   PMID:39096490   PMID:39147013   PMID:39298490  


Genomics

Comparative Map Data
Gdf15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,082,043 - 71,085,106 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl871,082,043 - 71,085,106 (-)EnsemblGRCm39 Ensembl
GRCm38870,629,393 - 70,632,470 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,629,393 - 70,632,456 (-)EnsemblGRCm38mm10GRCm38
MGSCv37873,153,293 - 73,155,534 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36873,558,382 - 73,561,082 (-)NCBIMGSCv36mm8
Celera873,186,175 - 73,188,416 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.15NCBI
GDF15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381918,386,158 - 18,389,176 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1918,374,731 - 18,389,176 (+)EnsemblGRCh38hg38GRCh38
GRCh371918,496,968 - 18,499,986 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361918,357,968 - 18,360,986 (+)NCBINCBI36Build 36hg18NCBI36
Build 341918,357,984 - 18,360,986NCBI
Celera1918,398,797 - 18,401,815 (+)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1918,062,378 - 18,063,268 (+)NCBIHuRef
CHM1_11918,497,209 - 18,500,231 (+)NCBICHM1_1
T2T-CHM13v2.01918,515,920 - 18,523,324 (+)NCBIT2T-CHM13v2.0
Gdf15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,838,436 - 18,842,022 (+)NCBIGRCr8
mRatBN7.21618,804,457 - 18,808,043 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,805,239 - 18,808,055 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,847,005 - 18,849,564 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,979,943 - 19,982,528 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,899,963 - 18,902,522 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01620,555,395 - 20,557,978 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,555,395 - 20,557,978 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,411,167 - 20,413,750 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,310,882 - 19,313,465 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11619,310,851 - 19,313,463 (+)NCBI
Celera1618,997,242 - 18,999,829 (+)NCBICelera
Cytogenetic Map16p14NCBI
Gdf15
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555243,123,760 - 3,125,621 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555243,123,513 - 3,125,642 (-)NCBIChiLan1.0ChiLan1.0
GDF15
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22023,235,317 - 23,249,754 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11922,255,036 - 22,258,089 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01917,864,840 - 17,867,883 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11918,835,216 - 18,838,470 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1918,835,216 - 18,838,470 (+)Ensemblpanpan1.1panPan2
GDF15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12044,633,131 - 44,636,842 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2044,634,588 - 44,636,821 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2044,547,490 - 44,551,239 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02045,119,086 - 45,122,834 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2045,120,542 - 45,122,775 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12044,356,357 - 44,360,107 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02044,766,491 - 44,770,241 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02045,041,907 - 45,045,657 (-)NCBIUU_Cfam_GSD_1.0
Gdf15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118203,305,463 - 203,310,650 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365962,854,841 - 2,857,111 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365962,854,620 - 2,857,018 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GDF15
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl259,408,904 - 59,411,358 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1259,409,035 - 59,411,356 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GDF15
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1616,853,397 - 16,861,924 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl616,852,971 - 16,861,964 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660742,479,299 - 2,485,699 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gdf15
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249081,634,174 - 1,636,242 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249081,633,927 - 1,636,242 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gdf15
69 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:280
Count of miRNA genes:133
Interacting mature miRNAs:138
Transcripts:ENSMUST00000003808, ENSMUST00000110103
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81477316071498244Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined866326836100326976Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3250657271740637Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83663015493455280Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84809006482090180Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84924559183245673Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85892810792928107Mouse
14746987Manh64_mmandible shape 64 (mouse)85050595884505958Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3250657271740637Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined866084397100084549Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84809006482090180Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85474046188740637Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84819016882190288Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85515925889159407Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined871032003105032123Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832506572117965439Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3250657271740637Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6418673698186736Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86466617698666325Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85050595884505958Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837867154110326632Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85913640493136404Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85629887290298872Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86872247983326976Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83250657271740637Mouse
11039503Ccc4_mcolitis susceptibility in the Collaborative Cross 4 (mouse)86517423778002730Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86151347995513605Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)84016229795416226Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85233484386334843Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined871032003105032123Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84474791478748059Mouse

Markers in Region
Gdf15  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38870,629,917 - 70,630,153UniSTSGRCm38
MGSCv37873,153,816 - 73,154,052UniSTSGRCm37
Celera873,186,698 - 73,186,934UniSTS
Cytogenetic Map8C1UniSTS
cM Map8 UniSTS
Gdf15  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38870,631,616 - 70,631,728UniSTSGRCm38
MGSCv37873,155,515 - 73,155,627UniSTSGRCm37
Celera873,188,397 - 73,188,509UniSTS
Cytogenetic Map8C1UniSTS


Sequence


Ensembl Acc Id: ENSMUST00000003808   ⟹   ENSMUSP00000003808
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl871,082,043 - 71,084,745 (-)Ensembl
GRCm38.p6 Ensembl870,629,393 - 70,632,095 (-)Ensembl
Ensembl Acc Id: ENSMUST00000110103   ⟹   ENSMUSP00000105730
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl871,082,044 - 71,085,106 (-)Ensembl
GRCm38.p6 Ensembl870,629,394 - 70,632,456 (-)Ensembl
RefSeq Acc Id: NM_001330687   ⟹   NP_001317616
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39871,082,043 - 71,085,106 (-)NCBI
GRCm38870,629,393 - 70,632,456 (-)NCBI
Sequence:
RefSeq Acc Id: NM_011819   ⟹   NP_035949
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39871,082,043 - 71,084,288 (-)NCBI
GRCm38870,629,393 - 70,632,095 (-)NCBI
MGSCv37873,153,293 - 73,155,534 (-)RGD
Celera873,186,175 - 73,188,416 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_035949   ⟸   NM_011819
- Peptide Label: preproprotein
- UniProtKB: Q6NX63 (UniProtKB/Swiss-Prot),   Q9Z0J7 (UniProtKB/Swiss-Prot),   Q3UNI4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001317616   ⟸   NM_001330687
- Peptide Label: preproprotein
- UniProtKB: Q6NX63 (UniProtKB/Swiss-Prot),   Q9Z0J7 (UniProtKB/Swiss-Prot),   Q3UNI4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000105730   ⟸   ENSMUST00000110103
Ensembl Acc Id: ENSMUSP00000003808   ⟸   ENSMUST00000003808
Protein Domains
TGF-beta family profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z0J7-F1-model_v2 AlphaFold Q9Z0J7 1-303 view protein structure

Promoters
RGD ID:8667329
Promoter ID:EPDNEW_M11696
Type:single initiation site
Name:Gdf15_1
Description:Mus musculus growth differentiation factor 15 , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38870,631,635 - 70,631,695EPDNEW
RGD ID:6849253
Promoter ID:MM_XEF:7095
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_001174056
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36873,153,636 - 73,154,612 (-)MPROMDB
RGD ID:6843185
Promoter ID:MM_KWN:54724
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000057884,   UC009MBB.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36873,155,311 - 73,157,107 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1346047 AgrOrtholog
Ensembl Genes ENSMUSG00000038508 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000003808 ENTREZGENE
  ENSMUST00000003808.8 UniProtKB/Swiss-Prot
  ENSMUST00000110103 ENTREZGENE
  ENSMUST00000110103.2 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-b_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:23886 UniProtKB/Swiss-Prot
MGD MGI:1346047 ENTREZGENE
NCBI Gene 23886 ENTREZGENE
PANTHER GROWTH/DIFFERENTIATION FACTOR 15 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11848 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gdf15 PhenoGen
PROSITE TGF_BETA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TGFB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt GDF15_MOUSE UniProtKB/Swiss-Prot
  Q3TU76_MOUSE UniProtKB/TrEMBL
  Q3UNI4 ENTREZGENE, UniProtKB/TrEMBL
  Q6NX63 ENTREZGENE
  Q9Z0J7 ENTREZGENE
UniProt Secondary Q6NX63 UniProtKB/Swiss-Prot