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Gene: Plce1 (phospholipase C, epsilon 1) Mus musculus
Symbol: Plce1
Name: phospholipase C, epsilon 1
RGD ID: 735564
Description: Predicted to have Ras GTPase binding activity and phosphatidylinositol phospholipase C activity. Predicted to be involved in several processes, including diacylglycerol biosynthetic process; intracellular signal transduction; and regulation of signal transduction. Predicted to localize to cytosol; lamellipodium; and plasma membrane. Is expressed in several structures, including facial bone primordium; heart; liver; nervous system; and thymus. Human ortholog(s) of this gene implicated in nephrotic syndrome; nephrotic syndrome type 2; and nephrotic syndrome type 3. Orthologous to human PLCE1 (phospholipase C epsilon 1); PARTICIPATES IN inositol phosphate metabolic pathway; phosphatidylinositol 3-kinase signaling pathway; INTERACTS WITH 1,1-dichloroethene; 1,2-dichloroethane; 2,3',4,4',5-Pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1; 4933403A21Rik; Gm3865; mKIAA1516; phosphoinositide phospholipase C-epsilon-1; phospholipase C-epsilon-1; PL; PLC-epsilon-1; Plce; PLCepsilon; predicted gene 3865
Homo sapiens (human) : PLCE1 (phospholipase C epsilon 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Plce1 (phospholipase C, epsilon 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Plce1 (phospholipase C epsilon 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PLCE1 (phospholipase C epsilon 1)
Canis lupus familiaris (dog) : PLCE1 (phospholipase C epsilon 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Plce1 (phospholipase C epsilon 1)
Sus scrofa (pig) : PLCE1 (phospholipase C epsilon 1)
Chlorocebus sabaeus (African green monkey) : PLCE1 (phospholipase C epsilon 1)
Heterocephalus glaber (naked mole-rat) : Plce1 (phospholipase C epsilon 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1938,481,109 - 38,785,030 (+)EnsemblGRCm38mm10GRCm38
GRCm381938,481,034 - 38,785,105 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371938,598,687 - 38,859,595 (+)NCBIGRCm37mm9NCBIm37
MGSCv361938,589,341 - 38,848,444 (+)NCBImm8
Celera1939,314,226 - 39,575,892 (+)NCBICelera
Cytogenetic Map19C3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Plce1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735564
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.