MCL1 (MCL1 apoptosis regulator, BCL2 family member) - Rat Genome Database

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Gene: MCL1 (MCL1 apoptosis regulator, BCL2 family member) Homo sapiens
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Symbol: MCL1
Name: MCL1 apoptosis regulator, BCL2 family member
RGD ID: 735512
HGNC Page HGNC:6943
Description: Enables BH3 domain binding activity and protein heterodimerization activity. Involved in extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of autophagy; and regulation of apoptotic process. Acts upstream of or within DNA damage response and response to cytokine. Located in membrane; mitochondrion; and nucleus. Part of Bcl-2 family protein complex. Implicated in colorectal cancer; lung adenocarcinoma; lung cancer; and lung non-small cell carcinoma. Biomarker of gastrointestinal system cancer (multiple) and lung cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: bcl-2-like protein 3; bcl-2-related protein EAT/mcl1; BCL2 family apoptosis regulator; bcl2-L-3; BCL2L3; EAT; induced myeloid leukemia cell differentiation protein Mcl-1; Mcl-1; MCL1, BCL2 family apoptosis regulator; MCL1-ES; mcl1/EAT; MCL1L; MCL1S; MGC104264; MGC1839; myeloid cell leukemia 1; myeloid cell leukemia ES; myeloid cell leukemia sequence 1; myeloid cell leukemia sequence 1 (BCL2-related); myeloid cell leukemia sequence 1, isoform 1; TM
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381150,574,558 - 150,579,610 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1150,560,895 - 150,579,738 (-)EnsemblGRCh38hg38GRCh38
GRCh371150,547,034 - 150,552,086 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361148,813,658 - 148,818,760 (-)NCBINCBI36Build 36hg18NCBI36
Build 341147,360,106 - 147,365,209NCBI
Celera1123,662,793 - 123,667,900 (-)NCBICelera
Cytogenetic Map1q21.2NCBI
HuRef1121,925,157 - 121,930,349 (-)NCBIHuRef
CHM1_11151,942,802 - 151,947,994 (-)NCBICHM1_1
T2T-CHM13v2.01149,698,578 - 149,703,635 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Tetrandrine  (EXP)
(-)-demecolcine  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(-)-marinopyrrole A  (EXP)
(1->4)-beta-D-glucan  (ISO)
(S)-naringenin  (EXP)
(S)-nicotine  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-(4-methoxybenzyl)-3-(5-nitro-1,3-thiazol-2-yl)urea  (EXP)
1-methylphenanthrene  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-methylcholine  (EXP)
3-bromopyruvic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methyladenine  (EXP)
3-phenylprop-2-enal  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-Nerolidylcatechol  (EXP)
4-nonylphenol  (ISO)
5-azacytidine  (EXP)
5-fluorouracil  (EXP,ISO)
6-bromoindirubin-3'-oxime  (EXP)
8'-apo-beta,psi-caroten-8'-al  (EXP)
ABT-737  (EXP)
acetaldehyde  (EXP)
acetochlor  (EXP)
acetylsalicylic acid  (EXP)
actinomycin D  (EXP)
afatinib  (EXP)
aflatoxin B1  (EXP)
aldehydo-D-glucosamine  (EXP)
all-trans-4-oxoretinoic acid  (EXP)
all-trans-4-oxoretinol  (EXP)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP)
alvocidib  (EXP)
ammonium chloride  (ISO)
amodiaquine  (EXP)
angiotensin II  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antimycin A  (EXP)
antirheumatic drug  (EXP)
apigenin  (ISO)
aprepitant  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
atorvastatin calcium  (EXP)
atrazine  (EXP)
auranofin  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzo[b]fluoranthene  (EXP)
beta-carotene  (EXP)
beta-D-glucosamine  (EXP)
beta-Elemonic acid  (EXP)
beta-lapachone  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bortezomib  (EXP,ISO)
bufalin  (EXP)
bupivacaine  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
cafestol  (EXP)
caffeine  (EXP)
calcitriol  (EXP)
calyculin a  (EXP)
cannabidiol  (EXP)
capsaicin  (EXP)
carbon nanotube  (ISO)
Cardanol  (EXP)
casticin  (EXP)
celecoxib  (EXP)
cepharanthine  (EXP)
ceritinib  (EXP)
CGP 52608  (EXP)
chloroacetic acid  (ISO)
chloroquine  (EXP)
ciprofloxacin  (EXP)
cirsilineol  (ISO)
cisplatin  (EXP)
clavulone II  (EXP)
clofarabine  (EXP)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (EXP)
copper(II) sulfate  (EXP)
coumarin  (EXP)
coumarins  (EXP)
crocidolite asbestos  (EXP)
Cryptotanshinone  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (EXP)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (EXP)
cytarabine  (EXP)
D-penicillamine  (EXP)
dacarbazine  (EXP)
dactolisib  (EXP)
daunorubicin  (EXP)
deguelin  (EXP)
desferrioxamine B  (EXP)
dexamethasone  (EXP,ISO)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (EXP)
Dibutyl phosphate  (EXP)
dibutyl phthalate  (ISO)
Dictamnine  (EXP)
dieldrin  (EXP)
diethylstilbestrol  (ISO)
diuron  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
emodin  (EXP,ISO)
entinostat  (EXP)
erlotinib hydrochloride  (EXP)
etacrynic acid  (EXP)
etoposide  (EXP)
fenthion  (ISO)
fenvalerate  (EXP)
flubendazole  (EXP)
fluvastatin  (EXP)
folic acid  (EXP,ISO)
formononetin  (EXP)
fucoxanthin  (EXP)
gamma-tocopherol  (EXP)
gentamycin  (ISO)
Geraniin  (EXP)
glycochenodeoxycholic acid  (EXP,ISO)
glyphosate  (EXP)
gossypol  (EXP)
Heptachlor epoxide  (ISO)
Honokiol  (EXP)
hydrogen chloride  (EXP)
hydroquinone  (EXP)
hydroxamic acid  (EXP)
hyperforin  (EXP)
ibuprofen  (EXP)
Ile(5)-angiotensin II  (EXP)
irinotecan  (EXP)
Isoangustone A  (EXP)
isoflurane  (ISO)
ivermectin  (EXP)
jaceosidin  (EXP)
ketoconazole  (EXP)
kurarinol  (EXP,ISO)
lead nitrate  (ISO)
leflunomide  (EXP)
leukotriene B4  (EXP)
lidocaine  (ISO)
lithium chloride  (EXP)
lithocholic acid  (ISO)
lonidamine  (EXP)
luteolin  (EXP)
LY294002  (EXP)
lysophosphatidylethanolamine  (EXP,ISO)
maneb  (EXP)
manganese(II) chloride  (ISO)
melatonin  (EXP,ISO)
mercury dichloride  (ISO)
metacetamol  (ISO)
metformin  (EXP)
methamphetamine  (ISO)
methidathion  (ISO)
methotrexate  (EXP,ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (ISO)
methylparaben  (EXP)
MK-2206  (EXP)
monocrotophos  (ISO)
morphine  (ISO)
Myrtucommulone A  (ISO)
N(6)-methyladenosine  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N,N-dimethylsphingosine  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
nelfinavir  (EXP)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (ISO)
niclosamide  (EXP)
nicotine  (EXP)
nitroprusside  (EXP)
Nonidet P-40  (EXP)
NORCANTHARIDIN  (EXP)
notoginsenoside R1  (ISO)
ochratoxin A  (EXP,ISO)
oltipraz  (ISO)
omacetaxine mepesuccinate  (EXP)
osimertinib  (EXP)
oxaliplatin  (EXP)
ozone  (EXP)
p-menthan-3-ol  (EXP)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraoxon  (ISO)
paraquat  (EXP)
PD 0325901  (EXP)
pentobarbital  (ISO)
Pentoxifylline  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl isothiocyanate  (EXP)
phenobarbital  (ISO)
phenol  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
picropodophyllotoxin  (EXP)
pinostrobin  (EXP)
pirinixic acid  (EXP,ISO)
ponatinib  (EXP)
potassium chromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
promethazine  (EXP)
propiconazole  (ISO)
propranolol  (EXP)
propylparaben  (EXP)
pterostilbene  (EXP)
pyrethrins  (EXP)
pyrimidines  (EXP)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
quinazolines  (EXP)
reactive oxygen species  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (EXP)
romidepsin  (EXP)
sarin  (EXP)
sepantronium  (EXP)
sertraline  (EXP)
silver atom  (EXP)
silver(0)  (EXP)
sirolimus  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
Sodium salicylate  (EXP)
Soman  (ISO)
sorafenib  (EXP,ISO)
staurosporine  (EXP)
sucrose  (ISO)
tamoxifen  (EXP,ISO)
tanespimycin  (EXP)
Tautomycin  (EXP)
tebufenpyrad  (EXP)
TEMPO  (ISO)
tert-butyl hydroperoxide  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
thalidomide  (EXP)
thapsigargin  (EXP)
thiostrepton  (EXP)
titanium dioxide  (ISO)
tocopherol  (EXP)
trametinib  (EXP)
trichostatin A  (EXP)
triphenyl phosphate  (EXP)
triphenylstannane  (EXP)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tunicamycin  (EXP)
tyrphostin AG 1478  (ISO)
urethane  (EXP)
ursodeoxycholic acid  (EXP)
usnic acid  (EXP)
valproic acid  (EXP,ISO)
vemurafenib  (EXP)
venetoclax  (EXP)
vinclozolin  (ISO)
vincristine  (EXP)
vorinostat  (EXP,ISO)
withaferin A  (EXP)
wortmannin  (EXP)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
Bcl-2 family protein complex  (IDA,IEA,IPI)
cytoplasm  (IEA,TAS)
cytosol  (IEA,ISS,TAS)
membrane  (IDA,IEA,ISS)
mitochondrial outer membrane  (IBA,TAS)
mitochondrion  (HTP,IDA,IEA)
myosin complex  (TAS)
nucleoplasm  (IEA)
nucleus  (IDA,IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. The Bcl-2 apoptotic switch in cancer development and therapy. Adams JM and Cory S, Oncogene. 2007 Feb 26;26(9):1324-37.
2. Degradation of MCL-1 by bufalin reverses acquired resistance to osimertinib in EGFR-mutant lung cancer. Cao F, etal., Toxicol Appl Pharmacol. 2019 Sep 15;379:114662. doi: 10.1016/j.taap.2019.114662. Epub 2019 Jul 10.
3. Mcl-1 Interacts with Akt to Promote Lung Cancer Progression. Chen G, etal., Cancer Res. 2019 Dec 15;79(24):6126-6138. doi: 10.1158/0008-5472.CAN-19-0950. Epub 2019 Oct 29.
4. Myeloid cell leukemia-1 protein expression and myeloid cell leukemia-1 gene amplification in non small cell lung cancer. El Jabbour T, etal., Indian J Pathol Microbiol. 2018 Jan-Mar;61(1):27-30. doi: 10.4103/IJPM.IJPM_731_16.
5. FBXO4 inhibits lung cancer cell survival by targeting Mcl-1 for degradation. Feng C, etal., Cancer Gene Ther. 2017 Aug;24(8):342-347. doi: 10.1038/cgt.2017.24. Epub 2017 Aug 4.
6. Aberrant expression of deubiquitylating enzyme USP9X predicts poor prognosis in gastric cancer. Fu X, etal., Clin Res Hepatol Gastroenterol. 2017 Dec;41(6):687-692. doi: 10.1016/j.clinre.2017.01.008. Epub 2017 Mar 6.
7. MCL1 Is Required for Maintenance of Intestinal Homeostasis and Prevention of Carcinogenesis in Mice. Healy ME, etal., Gastroenterology. 2020 Jul;159(1):183-199. doi: 10.1053/j.gastro.2020.03.017. Epub 2020 Mar 14.
8. Hepatocyte apoptosis is tumor promoting in murine nonalcoholic steatohepatitis. Hirsova P, etal., Cell Death Dis. 2020 Feb 3;11(2):80. doi: 10.1038/s41419-020-2283-9.
9. Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. Hsu SY, etal., Proc Natl Acad Sci U S A 1997 Nov 11;94(23):12401-6.
10. The FOXM1-induced resistance to oxaliplatin is partially mediated by its novel target gene Mcl-1 in gastric cancer cells. Hu CJ, etal., Biochim Biophys Acta. 2015 Mar;1849(3):290-9. doi: 10.1016/j.bbagrm.2014.11.008. Epub 2014 Dec 4.
11. Functional regulatory variants of MCL1 contribute to enhanced promoter activity and reduced risk of lung cancer in nonsmokers: implications for context-dependent phenotype of an antiapoptotic and antiproliferative gene in solid tumor. Jiang Y, etal., Cancer. 2012 Apr 15;118(8):2085-95. doi: 10.1002/cncr.26502. Epub 2011 Sep 1.
12. Degradation of Mcl-1 through GSK-3β Activation Regulates Apoptosis Induced by Bufalin in Non-Small Cell Lung Cancer H1975 Cells. Kang XH, etal., Cell Physiol Biochem. 2017;41(5):2067-2076. doi: 10.1159/000475438. Epub 2017 Apr 14.
13. Myeloid cell leukemia-1 regulates the cell growth and predicts prognosis in gastric cancer. Lee WS, etal., Int J Oncol. 2015 May;46(5):2154-62. doi: 10.3892/ijo.2015.2890. Epub 2015 Feb 10.
14. Correlation Between BCL2 and Mcl1 Single Nucleotide Polymorphisms and Chemotherapy Response in Jordanian Patients with Colorectal Cancer. Mhaidat NM, etal., Curr Pharm Biotechnol. 2021;22(5):646-653. doi: 10.2174/1389201021666200703200126.
15. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. MCL1 inhibition enhances the therapeutic effect of MEK inhibitors in KRAS-mutant lung adenocarcinoma cells. Tada M, etal., Lung Cancer. 2019 Jul;133:88-95. doi: 10.1016/j.lungcan.2019.05.014. Epub 2019 May 14.
18. Demethylation of miR-9-3 and miR-193a genes suppresses proliferation and promotes apoptosis in non-small cell lung cancer cell lines. Wang J, etal., Cell Physiol Biochem. 2013;32(6):1707-19. doi: 10.1159/000356605. Epub 2013 Dec 13.
19. Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing. Wen W, etal., Cell Discov. 2020 May 4;6:31. doi: 10.1038/s41421-020-0168-9. eCollection 2020.
20. Mcl-1 mediates TWEAK/Fn14-induced non-small cell lung cancer survival and therapeutic response. Whitsett TG, etal., Mol Cancer Res. 2014 Apr;12(4):550-9. doi: 10.1158/1541-7786.MCR-13-0458. Epub 2014 Jan 27.
21. NCAPH is negatively associated with Mcl‑1 in non‑small cell lung cancer. Xiong Q, etal., Mol Med Rep. 2020 Oct;22(4):2916-2924. doi: 10.3892/mmr.2020.11359. Epub 2020 Jul 28.
22. Copy-number variation of MCL1 predicts overall survival of non-small-cell lung cancer in a Southern Chinese population. Yin J, etal., Cancer Med. 2016 Sep;5(9):2171-9. doi: 10.1002/cam4.774. Epub 2016 Jun 5.
23. Magnolin promotes autophagy and cell cycle arrest via blocking LIF/Stat3/Mcl-1 axis in human colorectal cancers. Yu H, etal., Cell Death Dis. 2018 Jun 13;9(6):702. doi: 10.1038/s41419-018-0660-4.
24. Formononetin inhibits tumor growth by suppression of EGFR-Akt-Mcl-1 axis in non-small cell lung cancer. Yu X, etal., J Exp Clin Cancer Res. 2020 Apr 10;39(1):62. doi: 10.1186/s13046-020-01566-2.
Additional References at PubMed
PMID:7682708   PMID:7835896   PMID:7896880   PMID:8790944   PMID:9184696   PMID:9671497   PMID:9731710   PMID:9742125   PMID:10198631   PMID:10579309   PMID:10634649   PMID:10766760  
PMID:10837489   PMID:10965038   PMID:10978339   PMID:11130466   PMID:11483855   PMID:11546872   PMID:11598139   PMID:11781193   PMID:11877256   PMID:11911971   PMID:12057933   PMID:12070027  
PMID:12149273   PMID:12176902   PMID:12223490   PMID:12359245   PMID:12445202   PMID:12475993   PMID:12477932   PMID:12496428   PMID:12637318   PMID:12660820   PMID:12782407   PMID:12783855  
PMID:12787138   PMID:12855556   PMID:12901848   PMID:12915532   PMID:12960271   PMID:14633975   PMID:14982947   PMID:15014070   PMID:15077116   PMID:15078892   PMID:15122313   PMID:15126604  
PMID:15217829   PMID:15241487   PMID:15262975   PMID:15370246   PMID:15378010   PMID:15451437   PMID:15489334   PMID:15550399   PMID:15554878   PMID:15588513   PMID:15611089   PMID:15613543  
PMID:15626746   PMID:15637055   PMID:15694340   PMID:15713684   PMID:15721256   PMID:15728130   PMID:15753661   PMID:15842635   PMID:15870695   PMID:15901672   PMID:15902294   PMID:15940637  
PMID:15989957   PMID:16007132   PMID:16027162   PMID:16091744   PMID:16109713   PMID:16213503   PMID:16229017   PMID:16289418   PMID:16327976   PMID:16339575   PMID:16380381   PMID:16456709  
PMID:16478725   PMID:16538501   PMID:16543145   PMID:16697956   PMID:16710414   PMID:16725198   PMID:16761109   PMID:16782027   PMID:16822835   PMID:16901898   PMID:16969094   PMID:16978419  
PMID:17009247   PMID:17072336   PMID:17097560   PMID:17145774   PMID:17200126   PMID:17227835   PMID:17384650   PMID:17387146   PMID:17428862   PMID:17463001   PMID:17495975   PMID:17498302  
PMID:17525735   PMID:17545167   PMID:17553788   PMID:17561513   PMID:17599053   PMID:17670986   PMID:17698840   PMID:17805325   PMID:17823113   PMID:17893147   PMID:17907802   PMID:17927446  
PMID:17928528   PMID:17942758   PMID:18006817   PMID:18025305   PMID:18029348   PMID:18032706   PMID:18040043   PMID:18046444   PMID:18088462   PMID:18089567   PMID:18178565   PMID:18208354  
PMID:18209102   PMID:18234961   PMID:18292181   PMID:18415656   PMID:18452656   PMID:18483275   PMID:18495871   PMID:18543107   PMID:18552129   PMID:18599795   PMID:18609706   PMID:18647593  
PMID:18676738   PMID:18676833   PMID:18757878   PMID:18768389   PMID:18769617   PMID:18981409   PMID:19008456   PMID:19012245   PMID:19037233   PMID:19051025   PMID:19074266   PMID:19077158  
PMID:19092849   PMID:19099185   PMID:19148187   PMID:19150432   PMID:19167051   PMID:19285955   PMID:19288493   PMID:19369967   PMID:19372583   PMID:19401626   PMID:19481066   PMID:19483105  
PMID:19484260   PMID:19503096   PMID:19523441   PMID:19549371   PMID:19571464   PMID:19581935   PMID:19582795   PMID:19587033   PMID:19605477   PMID:19616548   PMID:19622586   PMID:19634140  
PMID:19654003   PMID:19676043   PMID:19683529   PMID:19684859   PMID:19734538   PMID:19737931   PMID:19748896   PMID:19763916   PMID:19773546   PMID:19782681   PMID:19808698   PMID:19838163  
PMID:19840460   PMID:19841168   PMID:19887550   PMID:19913121   PMID:19933775   PMID:19942343   PMID:19949310   PMID:19955184   PMID:19965632   PMID:19966861   PMID:19968497   PMID:19968719  
PMID:19968986   PMID:20004446   PMID:20007713   PMID:20023629   PMID:20038816   PMID:20041405   PMID:20051518   PMID:20066663   PMID:20066738   PMID:20074640   PMID:20085644   PMID:20085765  
PMID:20156337   PMID:20173022   PMID:20189983   PMID:20197552   PMID:20308427   PMID:20392693   PMID:20467439   PMID:20501829   PMID:20503275   PMID:20526282   PMID:20571074   PMID:20628086  
PMID:20647761   PMID:20677014   PMID:20693279   PMID:20802294   PMID:20829524   PMID:20836993   PMID:20921992   PMID:21036904   PMID:21132008   PMID:21138867   PMID:21139567   PMID:21139584  
PMID:21145489   PMID:21148306   PMID:21151390   PMID:21199865   PMID:21216463   PMID:21220745   PMID:21228225   PMID:21247487   PMID:21253591   PMID:21258408   PMID:21292770   PMID:21298030  
PMID:21368833   PMID:21393866   PMID:21406400   PMID:21412051   PMID:21423203   PMID:21454712   PMID:21458670   PMID:21471522   PMID:21504623   PMID:21507240   PMID:21516346   PMID:21566062  
PMID:21596068   PMID:21613222   PMID:21628457   PMID:21659544   PMID:21670080   PMID:21674276   PMID:21730980   PMID:21734342   PMID:21750559   PMID:21824245   PMID:21841196   PMID:21846680  
PMID:21863213   PMID:21873635   PMID:21896753   PMID:21899728   PMID:21907705   PMID:21923740   PMID:21947543   PMID:21951844   PMID:21952639   PMID:21983785   PMID:21993632   PMID:22024133  
PMID:22056880   PMID:22072062   PMID:22108005   PMID:22125448   PMID:22152474   PMID:22188816   PMID:22190034   PMID:22194343   PMID:22203987   PMID:22219388   PMID:22231730   PMID:22253918  
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PMID:23195034   PMID:23245996   PMID:23257783   PMID:23301543   PMID:23341456   PMID:23364598   PMID:23369735   PMID:23418490   PMID:23431241   PMID:23455323   PMID:23456625   PMID:23463670  
PMID:23478333   PMID:23503679   PMID:23524145   PMID:23546867   PMID:23547049   PMID:23580240   PMID:23585552   PMID:23608884   PMID:23611778   PMID:23618862   PMID:23636231   PMID:23640248  
PMID:23680104   PMID:23681223   PMID:23696245   PMID:23711389   PMID:23750239   PMID:23756231   PMID:23790646   PMID:23858059   PMID:23872733   PMID:23883584   PMID:23887890   PMID:23904379  
PMID:23954445   PMID:23977882   PMID:23991020   PMID:24019208   PMID:24025188   PMID:24038028   PMID:24040284   PMID:24091677   PMID:24113155   PMID:24118207   PMID:24127964   PMID:24213575  
PMID:24234443   PMID:24260268   PMID:24263101   PMID:24280938   PMID:24369359   PMID:24481815   PMID:24491548   PMID:24525728   PMID:24529193   PMID:24556678   PMID:24556687   PMID:24564888  
PMID:24568469   PMID:24650799   PMID:24680709   PMID:24735609   PMID:24742042   PMID:24756163   PMID:24769731   PMID:24789074   PMID:24811082   PMID:24811167   PMID:24852432   PMID:24865469  
PMID:24870742   PMID:24939844   PMID:24947165   PMID:24969872   PMID:24991768   PMID:24999239   PMID:25024216   PMID:25043081   PMID:25062042   PMID:25076060   PMID:25084985   PMID:25091479  
PMID:25107702   PMID:25147182   PMID:25194337   PMID:25196280   PMID:25208882   PMID:25210795   PMID:25231749   PMID:25270224   PMID:25275312   PMID:25296978   PMID:25304383   PMID:25314294  
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PMID:26921175   PMID:26921340   PMID:26939706   PMID:26959881   PMID:26972000   PMID:27013495   PMID:27020498   PMID:27049076   PMID:27055871   PMID:27063186   PMID:27103402   PMID:27120977  
PMID:27138804   PMID:27159593   PMID:27166195   PMID:27217294   PMID:27234233   PMID:27246906   PMID:27278254   PMID:27307592   PMID:27351224   PMID:27367564   PMID:27409838   PMID:27420766  
PMID:27432908   PMID:27453043   PMID:27455555   PMID:27465322   PMID:27479182   PMID:27517746   PMID:27528663   PMID:27537523   PMID:27582546   PMID:27686452   PMID:27697610   PMID:27701804  
PMID:27738316   PMID:27765849   PMID:27818144   PMID:27821478   PMID:27871464   PMID:27875574   PMID:27893461   PMID:27913212   PMID:27939888   PMID:27956387   PMID:28031117   PMID:28038464  
PMID:28039357   PMID:28079887   PMID:28112581   PMID:28151428   PMID:28154184   PMID:28182008   PMID:28190086   PMID:28192408   PMID:28193319   PMID:28202514   PMID:28261909   PMID:28298427  
PMID:28301598   PMID:28319085   PMID:28337703   PMID:28347402   PMID:28393212   PMID:28423543   PMID:28423654   PMID:28485156   PMID:28514442   PMID:28522751   PMID:28590547   PMID:28611106  
PMID:28619760   PMID:28649004   PMID:28663057   PMID:28667119   PMID:28681695   PMID:28687276   PMID:28692117   PMID:28751497   PMID:28751770   PMID:28760656   PMID:28765329   PMID:28863158  
PMID:28939105   PMID:28945224   PMID:28947420   PMID:28970067   PMID:28974549   PMID:28978427   PMID:29068469   PMID:29110251   PMID:29113504   PMID:29118074   PMID:29203282   PMID:29205703  
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PMID:29845223   PMID:29895675   PMID:29908077   PMID:29924888   PMID:29937479   PMID:29987118   PMID:30021884   PMID:30030896   PMID:30131584   PMID:30194290   PMID:30224339   PMID:30302867  
PMID:30445933   PMID:30468106   PMID:30518744   PMID:30538285   PMID:30543142   PMID:30569090   PMID:30596398   PMID:30631150   PMID:30633583   PMID:30649895   PMID:30718431   PMID:30728351  
PMID:30762338   PMID:30773399   PMID:30777879   PMID:30782845   PMID:30912136   PMID:31043700   PMID:31150457   PMID:31264507   PMID:31294695   PMID:31297886   PMID:31337603   PMID:31399555  
PMID:31434979   PMID:31467488   PMID:31497917   PMID:31536960   PMID:31570787   PMID:31586073   PMID:31601252   PMID:31601883   PMID:31601924   PMID:31669390   PMID:31706839   PMID:31744877  
PMID:31751869   PMID:31753743   PMID:31754782   PMID:31907390   PMID:31919392   PMID:31941601   PMID:32014946   PMID:32015503   PMID:32081857   PMID:32094511   PMID:32111816   PMID:32193910  
PMID:32203216   PMID:32204955   PMID:32223928   PMID:32249419   PMID:32296028   PMID:32296183   PMID:32319395   PMID:32352219   PMID:32371858   PMID:32378766   PMID:32423001   PMID:32430171  
PMID:32444799   PMID:32457483   PMID:32484436   PMID:32504673   PMID:32513696   PMID:32527042   PMID:32572959   PMID:32585451   PMID:32587776   PMID:32675387   PMID:32682001   PMID:32682341  
PMID:32710568   PMID:32777522   PMID:32802178   PMID:32913197   PMID:32913203   PMID:32928910   PMID:32932732   PMID:32961017   PMID:32986659   PMID:33050112   PMID:33093207   PMID:33129955  
PMID:33184242   PMID:33202208   PMID:33203722   PMID:33300066   PMID:33306668   PMID:33353284   PMID:33446629   PMID:33471866   PMID:33508399   PMID:33589591   PMID:33600840   PMID:33627786  
PMID:33658484   PMID:33690800   PMID:33851636   PMID:33898171   PMID:33961781   PMID:33977869   PMID:34079080   PMID:34099633   PMID:34107118   PMID:34270823   PMID:34299435   PMID:34305242  
PMID:34314700   PMID:34332981   PMID:34343635   PMID:34349018   PMID:34359829   PMID:34373451   PMID:34475520   PMID:34606682   PMID:34667112   PMID:34685622   PMID:34707185   PMID:34741373  
PMID:34758305   PMID:34800366   PMID:34857952   PMID:34963561   PMID:35042842   PMID:35058488   PMID:35136016   PMID:35220217   PMID:35221802   PMID:35229202   PMID:35235311   PMID:35301297  
PMID:35338135   PMID:35354755   PMID:35391656   PMID:35429048   PMID:35457012   PMID:35462114   PMID:35668118   PMID:36104324   PMID:36104628   PMID:36215168   PMID:36226498   PMID:36260529  
PMID:36346691   PMID:36416587   PMID:36535926   PMID:36724073   PMID:36869017   PMID:36918717   PMID:37142223   PMID:37160897   PMID:37167062   PMID:37259388   PMID:37314216   PMID:37317656  
PMID:37349598   PMID:37433992   PMID:37467344   PMID:37676378   PMID:38055341   PMID:38256213   PMID:38334954   PMID:38661028   PMID:39213434  


Genomics

Comparative Map Data
MCL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381150,574,558 - 150,579,610 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1150,560,895 - 150,579,738 (-)EnsemblGRCh38hg38GRCh38
GRCh371150,547,034 - 150,552,086 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361148,813,658 - 148,818,760 (-)NCBINCBI36Build 36hg18NCBI36
Build 341147,360,106 - 147,365,209NCBI
Celera1123,662,793 - 123,667,900 (-)NCBICelera
Cytogenetic Map1q21.2NCBI
HuRef1121,925,157 - 121,930,349 (-)NCBIHuRef
CHM1_11151,942,802 - 151,947,994 (-)NCBICHM1_1
T2T-CHM13v2.01149,698,578 - 149,703,635 (-)NCBIT2T-CHM13v2.0
Mcl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39395,564,017 - 95,583,553 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl395,566,099 - 95,570,487 (+)EnsemblGRCm39 Ensembl
GRCm38395,656,944 - 95,663,179 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl395,658,788 - 95,663,176 (+)EnsemblGRCm38mm10GRCm38
MGSCv37395,462,643 - 95,467,102 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36395,744,192 - 95,748,584 (+)NCBIMGSCv36mm8
MGSCv36395,942,505 - 95,946,924 (+)NCBIMGSCv36mm8
Celera397,090,304 - 97,094,626 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map340.74NCBI
Mcl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82185,884,840 - 185,912,532 (+)NCBIGRCr8
mRatBN7.22183,219,137 - 183,235,676 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2183,219,220 - 183,222,303 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2190,884,075 - 190,887,160 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02188,679,562 - 188,682,647 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02183,516,603 - 183,519,688 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02197,786,212 - 197,788,992 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02217,273,158 - 217,275,930 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2175,749,995 - 175,752,956 (+)NCBICelera
Cytogenetic Map2q34NCBI
Mcl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955413238,043 - 243,317 (+)NCBIChiLan1.0ChiLan1.0
MCL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2199,257,840 - 99,264,868 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1199,013,464 - 99,018,758 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01125,918,760 - 125,923,952 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11129,566,827 - 129,572,086 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1129,566,827 - 129,572,086 (-)Ensemblpanpan1.1panPan2
MCL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11759,759,605 - 59,763,111 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1759,759,605 - 59,763,111 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1759,205,905 - 59,209,411 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01760,773,751 - 60,778,808 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1760,773,753 - 60,778,722 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11759,605,427 - 59,608,935 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01759,689,378 - 59,692,878 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01760,416,999 - 60,420,508 (-)NCBIUU_Cfam_GSD_1.0
Mcl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505821,772,943 - 21,777,059 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936580804,903 - 806,796 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936580803,452 - 806,966 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MCL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl498,534,812 - 98,567,006 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1498,562,092 - 98,567,014 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24107,809,204 - 107,814,036 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MCL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366603812,707,472 - 12,712,711 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mcl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477218,289,509 - 18,319,033 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477218,287,587 - 18,292,384 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MCL1
19 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1q21.2-25.2(chr1:149854269-180267197)x3 copy number gain See cases [RCV000143515] Chr1:149854269..180267197 [GRCh38]
Chr1:149825831..180236332 [GRCh37]
Chr1:148092455..178502955 [NCBI36]
Chr1:1q21.2-25.2
pathogenic
GRCh37/hg19 1q21.3(chr1:150531540-150679158)x3 copy number gain Breast ductal adenocarcinoma [RCV000207143] Chr1:150531540..150679158 [GRCh37]
Chr1:1q21.3
uncertain significance
GRCh37/hg19 1q21.1-21.3(chr1:144927578-153223600)x3 copy number gain Chromosome 1q21.1 duplication syndrome [RCV000223957] Chr1:144927578..153223600 [GRCh37]
Chr1:1q21.1-21.3
pathogenic
GRCh37/hg19 1q21.1-21.3(chr1:143753740-151399970)x3 copy number gain See cases [RCV000447109] Chr1:143753740..151399970 [GRCh37]
Chr1:1q21.1-21.3
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
NM_021960.5(MCL1):c.131C>T (p.Ala44Val) single nucleotide variant not specified [RCV004318811] Chr1:150579400 [GRCh38]
Chr1:150551876 [GRCh37]
Chr1:1q21.2
uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1q21.3(chr1:150529738-150549863)x3 copy number gain not provided [RCV000749186] Chr1:150529738..150549863 [GRCh37]
Chr1:1q21.3
benign
NM_021960.5(MCL1):c.732A>G (p.Lys244=) single nucleotide variant not provided [RCV000950063] Chr1:150578448 [GRCh38]
Chr1:150578448..150578449 [GRCh38]
Chr1:150550924 [GRCh37]
Chr1:150550924..150550925 [GRCh37]
Chr1:1q21.2
benign
NM_021960.5(MCL1):c.1031G>T (p.Gly344Val) single nucleotide variant High myopia [RCV000785738] Chr1:150577397 [GRCh38]
Chr1:150549873 [GRCh37]
Chr1:1q21.2
uncertain significance
NM_021960.5(MCL1):c.688+9G>T single nucleotide variant not provided [RCV000888901] Chr1:150578834 [GRCh38]
Chr1:150551310 [GRCh37]
Chr1:1q21.2
benign
NM_021960.5(MCL1):c.358A>G (p.Met120Val) single nucleotide variant not provided [RCV000971254] Chr1:150579173 [GRCh38]
Chr1:150551649 [GRCh37]
Chr1:1q21.2
benign
NC_000001.10:g.(?_130980840)_(248900000_?)dup duplication Gastrointestinal stromal tumor [RCV001300221]|Parathyroid carcinoma [RCV001341077] Chr1:130980840..248900000 [GRCh37]
Chr1:1q12-44
uncertain significance
NC_000001.10:g.(?_149895434)_(156851434_?)dup duplication Autosomal recessive mendelian susceptibility to mycobacterial diseases due to complete RORgamma receptor deficiency [RCV001958273]|Congenital neutropenia-myelofibrosis-nephromegaly syndrome [RCV001958271]|Kostmann syndrome [RCV003120769]|MHC class II deficiency [RCV001992607] Chr1:149895434..156851434 [GRCh37]
Chr1:1q21.2-23.1
uncertain significance
NM_021960.5(MCL1):c.133C>T (p.Arg45Trp) single nucleotide variant not specified [RCV004098987] Chr1:150579398 [GRCh38]
Chr1:150551874 [GRCh37]
Chr1:1q21.2
uncertain significance
NM_021960.5(MCL1):c.307C>T (p.Arg103Cys) single nucleotide variant not specified [RCV004074972] Chr1:150579224 [GRCh38]
Chr1:150551700 [GRCh37]
Chr1:1q21.2
uncertain significance
NM_021960.5(MCL1):c.431T>C (p.Leu144Pro) single nucleotide variant not specified [RCV004246621] Chr1:150579100 [GRCh38]
Chr1:150551576 [GRCh37]
Chr1:1q21.2
uncertain significance
NM_021960.5(MCL1):c.929G>A (p.Arg310Lys) single nucleotide variant not specified [RCV004122144] Chr1:150578251 [GRCh38]
Chr1:150550727 [GRCh37]
Chr1:1q21.2
uncertain significance
NM_021960.5(MCL1):c.322C>G (p.Leu108Val) single nucleotide variant not specified [RCV004101152] Chr1:150579209 [GRCh38]
Chr1:150551685 [GRCh37]
Chr1:1q21.2
uncertain significance
NM_021960.5(MCL1):c.304A>C (p.Thr102Pro) single nucleotide variant not specified [RCV004170694] Chr1:150579227 [GRCh38]
Chr1:150551703 [GRCh37]
Chr1:1q21.2
uncertain significance
GRCh37/hg19 1q12-23.1(chr1:142535935-157648813)x3 copy number gain Chromosome 1q21.1 duplication syndrome [RCV003329522] Chr1:142535935..157648813 [GRCh37]
Chr1:1q12-23.1
pathogenic
NM_021960.5(MCL1):c.960T>C (p.His320=) single nucleotide variant not specified [RCV004340203] Chr1:150577468 [GRCh38]
Chr1:150549944 [GRCh37]
Chr1:1q21.2
likely benign
GRCh37/hg19 1q21.1-23.1(chr1:144368497-158992086)x3 copy number gain not specified [RCV003986717] Chr1:144368497..158992086 [GRCh37]
Chr1:1q21.1-23.1
pathogenic
GRCh37/hg19 1q21.1-23.1(chr1:146577511-157155587)x3 copy number gain not specified [RCV003987261] Chr1:146577511..157155587 [GRCh37]
Chr1:1q21.1-23.1
pathogenic
NM_021960.5(MCL1):c.1038A>G (p.Ala346=) single nucleotide variant not specified [RCV004419161] Chr1:150577390 [GRCh38]
Chr1:150549866 [GRCh37]
Chr1:1q21.2
likely benign
NM_021960.5(MCL1):c.673G>C (p.Glu225Gln) single nucleotide variant not specified [RCV004419162] Chr1:150578858 [GRCh38]
Chr1:150551334 [GRCh37]
Chr1:1q21.2
uncertain significance
NM_021960.5(MCL1):c.1002T>C (p.Ala334=) single nucleotide variant not specified [RCV004636637] Chr1:150577426 [GRCh38]
Chr1:150549902 [GRCh37]
Chr1:1q21.2
likely benign
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR512-2hsa-miR-512-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI19503096
MIR512-2hsa-miR-512-5pOncomiRDBexternal_infoNANA19503096
MIR661hsa-miR-661Mirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20829195
MIR101-2hsa-miR-101-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blot//Functional MTI19155302
MIR101-2hsa-miR-101-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20829195
MIR101-2hsa-miR-101-3pOncomiRDBexternal_infoNANA19155302
MIR26A1hsa-miR-26a-5pMirtarbaseexternal_infoWestern blotFunctional MTI23750239
MIR29B1hsa-miR-29b-3pMirtarbaseexternal_infoLuciferase reporter assay//Reporter assay;OtherFunctional MTI17404574
MIR29B1hsa-miR-29b-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI20041405
MIR29B1hsa-miR-29b-3pOncomiRDBexternal_infoNANA21951844
MIR29B1hsa-miR-29b-3pOncomiRDBexternal_infoNANA20657750
MIR29B1hsa-miR-29b-3pOncomiRDBexternal_infoNANA19850741
MIR29B1hsa-miR-29b-3pOncomiRDBexternal_infoNANA17404574
MIR29Ahsa-miR-29a-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI20041405
MIR29Chsa-miR-29c-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI20041405
MIR29Chsa-miR-29c-3pOncomiRDBexternal_infoNANA23142283
MIR29Chsa-miR-29c-3pOncomiRDBexternal_infoNANA23001726
MIR148Bhsa-miR-148b-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20829195
MIR582hsa-miR-582-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20829195
MIR876hsa-miR-876-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20829195
MIR125B1hsa-miR-125b-5pOncomiRDBexternal_infoNANA22942733
MIR125B1hsa-miR-125b-5pOncomiRDBexternal_infoNANA22824797
MIR181B2hsa-miR-181b-5pOncomiRDBexternal_infoNANA21636858
MIR181B2hsa-miR-181b-5pOncomiRDBexternal_infoNANA20693279
MIR26A2hsa-miR-26a-5pMirtarbaseexternal_infoWestern blotFunctional MTI23750239
MIR320Ahsa-miR-320aMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19096009
MIR320Ahsa-miR-320aMirecordsexternal_infoNANA19070389
MIR181B1hsa-miR-181b-5pOncomiRDBexternal_infoNANA21636858
MIR181B1hsa-miR-181b-5pOncomiRDBexternal_infoNANA20693279
MIR125B2hsa-miR-125b-5pOncomiRDBexternal_infoNANA22942733
MIR125B2hsa-miR-125b-5pOncomiRDBexternal_infoNANA22824797
MIR193Bhsa-miR-193b-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20103677
MIR193Bhsa-miR-193b-3pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)20304954
MIR101-1hsa-miR-101-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blot//Functional MTI19155302
MIR101-1hsa-miR-101-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20829195
MIR193Bhsa-miR-193b-3pOncomiRDBexternal_infoNANA21893020
MIR518A2hsa-miR-518a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20829195
MIR101-1hsa-miR-101-3pOncomiRDBexternal_infoNANA19155302
MIR133Bhsa-miR-133bOncomiRDBexternal_infoNANA19654003
MIR193Ahsa-miR-193a-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotNon-Functional MTI18381414
MIR193Ahsa-miR-193a-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20829195
MIR193Ahsa-miR-193a-3pMirtarbaseexternal_infoImmunofluorescence//Luciferase reporter assay//WesFunctional MTI23546867
MIR29B2hsa-miR-29b-3pMirtarbaseexternal_infoLuciferase reporter assay//Reporter assay;OtherFunctional MTI17404574
MIR29B2hsa-miR-29b-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI20041405
MIR29B2hsa-miR-29b-3pOncomiRDBexternal_infoNANA21951844
MIR29B2hsa-miR-29b-3pOncomiRDBexternal_infoNANA20657750
MIR29B2hsa-miR-29b-3pOncomiRDBexternal_infoNANA19850741
MIR29B2hsa-miR-29b-3pOncomiRDBexternal_infoNANA17404574
MIR892Bhsa-miR-892bMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20829195

Predicted Target Of
Summary Value
Count of predictions:1261
Count of miRNA genes:722
Interacting mature miRNAs:805
Transcripts:ENST00000307940, ENST00000369026, ENST00000464132
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407359367GWAS1008343_Hserum gamma-glutamyl transferase measurement QTL GWAS1008343 (human)1e-19serum gamma-glutamyl transferase measurementserum gamma-glutamyltransferase activity level (CMO:0002241)1150578851150578852Human
407272006GWAS920982_Hbody height QTL GWAS920982 (human)1e-23body height (VT:0001253)body height (CMO:0000106)1150579566150579567Human
406964357GWAS613333_Hbasophil count, eosinophil count QTL GWAS613333 (human)4e-11eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)1150578448150578449Human
406954890GWAS603866_Heosinophil count QTL GWAS603866 (human)2e-10eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)1150578448150578449Human
406926028GWAS575004_Hdiastolic blood pressure, systolic blood pressure QTL GWAS575004 (human)4e-08diastolic blood pressure, systolic blood pressuresystolic blood pressure (CMO:0000004)1150578819150578820Human
407366026GWAS1015002_Haspartate aminotransferase to alanine aminotransferase ratio QTL GWAS1015002 (human)2e-09aspartate aminotransferase to alanine aminotransferase ratioserum aspartate aminotransferase activity level to alanine aminotransferase activity level ratio (CMO:0002245)1150578851150578852Human
406999501GWAS648477_Hvital capacity QTL GWAS648477 (human)1e-33vital capacity1150575271150575272Human
407388440GWAS1037416_Hsystolic blood pressure QTL GWAS1037416 (human)2e-08systolic blood pressuresystolic blood pressure (CMO:0000004)1150578851150578852Human
407355351GWAS1004327_Hpulse pressure measurement QTL GWAS1004327 (human)7e-09pulse pressure measurementpulse pressure (CMO:0000292)1150578851150578852Human
1357381BW57_HBody weight QTL 57 (human)10.0001Body weightfat free mass after exercise training1140630236166630236Human
407054609GWAS703585_Hvital capacity QTL GWAS703585 (human)2e-31vital capacity1150575271150575272Human
406994007GWAS642983_Hmean corpuscular volume QTL GWAS642983 (human)4e-12mean corpuscular volumemean corpuscular volume (CMO:0000038)1150577050150577051Human
407205661GWAS854637_Hforced expiratory volume QTL GWAS854637 (human)2e-11forced expiratory volumeforced expiratory volume (CMO:0000254)1150578851150578852Human
406948769GWAS597745_Hprotein measurement QTL GWAS597745 (human)1e-13protein measurement1150578819150578820Human
407395820GWAS1044796_Hsystolic blood pressure QTL GWAS1044796 (human)0.000004systolic blood pressuresystolic blood pressure (CMO:0000004)1150578851150578852Human
407204321GWAS853297_HFEV/FVC ratio QTL GWAS853297 (human)6e-08FEV/FVC ratioforced expiratory volume to forced vital capacity ratio (CMO:0000241)1150579566150579567Human
407373280GWAS1022256_Hserum alanine aminotransferase measurement QTL GWAS1022256 (human)1e-14serum alanine aminotransferase measurementserum alanine aminotransferase activity level (CMO:0000575)1150578851150578852Human
406948776GWAS597752_Hkeratin, type II cytoskeletal 5 measurement QTL GWAS597752 (human)9e-19keratin, type II cytoskeletal 5 measurement1150578819150578820Human
407358062GWAS1007038_Hpulse pressure measurement QTL GWAS1007038 (human)3e-09pulse pressure measurementpulse pressure (CMO:0000292)1150578851150578852Human
407357869GWAS1006845_Hsystolic blood pressure QTL GWAS1006845 (human)9e-08systolic blood pressuresystolic blood pressure (CMO:0000004)1150578851150578852Human
406920556GWAS569532_Hcancer QTL GWAS569532 (human)0.000007cancer1150575271150575272Human
406942448GWAS591424_Hforced expiratory volume QTL GWAS591424 (human)2e-21forced expiratory volumeforced expiratory volume (CMO:0000254)1150575271150575272Human
407207863GWAS856839_Hmean corpuscular hemoglobin QTL GWAS856839 (human)8e-10mean corpuscular hemoglobinmean corpuscular hemoglobin (CMO:0000290)1150578819150578820Human
407203894GWAS852870_Hvital capacity QTL GWAS852870 (human)3e-18vital capacity1150578851150578852Human
407339699GWAS988675_Hmean corpuscular hemoglobin QTL GWAS988675 (human)6e-12mean corpuscular hemoglobinmean corpuscular hemoglobin (CMO:0000290)1150578819150578820Human
407005109GWAS654085_HCCL2 measurement QTL GWAS654085 (human)0.000004CCL2 measurement1150579566150579567Human
407103034GWAS752010_Hvital capacity QTL GWAS752010 (human)5e-28vital capacity1150575271150575272Human
406984697GWAS633673_Hsystolic blood pressure QTL GWAS633673 (human)1e-09systolic blood pressuresystolic blood pressure (CMO:0000004)1150578851150578852Human

Markers in Region
SHGC-34987  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371150,547,654 - 150,547,754UniSTSGRCh37
Build 361148,814,278 - 148,814,378RGDNCBI36
Celera1123,663,413 - 123,663,513RGD
Cytogenetic Map1q21UniSTS
HuRef1121,925,784 - 121,925,884UniSTS
GeneMap99-GB4 RH Map1544.14UniSTS
Whitehead-RH Map1645.1UniSTS
GeneMap99-G3 RH Map17686.0UniSTS
RH67950  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371150,547,172 - 150,547,338UniSTSGRCh37
Build 361148,813,796 - 148,813,962RGDNCBI36
Celera1123,662,931 - 123,663,097RGD
Cytogenetic Map1q21UniSTS
HuRef1121,925,302 - 121,925,468UniSTS
PMC152246P2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371150,551,457 - 150,551,533UniSTSGRCh37
Build 361148,818,081 - 148,818,157RGDNCBI36
Celera1123,667,221 - 123,667,297RGD
Cytogenetic Map1q21UniSTS
HuRef1121,929,592 - 121,929,668UniSTS
MCL1_369  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371150,548,461 - 150,549,340UniSTSGRCh37
Build 361148,815,085 - 148,815,964RGDNCBI36
Celera1123,664,220 - 123,665,103RGD
HuRef1121,926,591 - 121,927,474UniSTS
SHGC-2474  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371150,547,256 - 150,547,465UniSTSGRCh37
Build 361148,813,880 - 148,814,089RGDNCBI36
Celera1123,663,015 - 123,663,224RGD
Cytogenetic Map1q21UniSTS
HuRef1121,925,386 - 121,925,595UniSTS
GeneMap99-G3 RH Map13989.0UniSTS
RH68997  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371150,547,075 - 150,547,297UniSTSGRCh37
Build 361148,813,699 - 148,813,921RGDNCBI36
Celera1123,662,834 - 123,663,056RGD
Cytogenetic Map1q21UniSTS
HuRef1121,925,205 - 121,925,427UniSTS
GeneMap99-GB4 RH Map1544.74UniSTS
NCBI RH Map11011.4UniSTS
RH78781  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371150,551,549 - 150,551,686UniSTSGRCh37
Build 361148,818,173 - 148,818,310RGDNCBI36
Celera1123,667,313 - 123,667,450RGD
Cytogenetic Map1q21UniSTS
HuRef1121,929,684 - 121,929,821UniSTS
GeneMap99-GB4 RH Map1541.42UniSTS
NCBI RH Map11064.8UniSTS
D1S3568  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371150,548,512 - 150,548,645UniSTSGRCh37
Build 361148,815,136 - 148,815,269RGDNCBI36
Celera1123,664,271 - 123,664,404RGD
Cytogenetic Map1q21UniSTS
HuRef1121,926,642 - 121,926,775UniSTS
GeneMap99-GB4 RH Map1544.74UniSTS
WI-20019  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1q21UniSTS
GeneMap99-GB4 RH Map1537.93UniSTS
Whitehead-RH Map1643.7UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2439 2788 2253 4974 1726 2351 6 624 1951 465 2270 7306 6472 53 3734 1 852 1744 1617 175 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_029146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001197320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_021960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_182763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA453505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF118124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF118276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF118277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF118278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF147742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF198614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF203373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH009713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK294462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK297217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK304775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK316267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL356356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC017197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC071897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC107735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT006640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA421486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ088966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ917536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L08246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000307940   ⟹   ENSP00000309973
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1150,577,070 - 150,579,530 (-)Ensembl
Ensembl Acc Id: ENST00000369026   ⟹   ENSP00000358022
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1150,574,558 - 150,579,610 (-)Ensembl
Ensembl Acc Id: ENST00000464132
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1150,574,176 - 150,579,477 (-)Ensembl
Ensembl Acc Id: ENST00000617352
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1150,560,895 - 150,574,552 (-)Ensembl
Ensembl Acc Id: ENST00000620947   ⟹   ENSP00000477624
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1150,574,551 - 150,579,738 (-)Ensembl
Ensembl Acc Id: ENST00000676522
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1150,574,720 - 150,579,594 (-)Ensembl
Ensembl Acc Id: ENST00000678610   ⟹   ENSP00000503149
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1150,574,176 - 150,579,597 (-)Ensembl
Ensembl Acc Id: ENST00000678770   ⟹   ENSP00000502859
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1150,563,102 - 150,579,610 (-)Ensembl
RefSeq Acc Id: NM_001197320   ⟹   NP_001184249
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381150,574,558 - 150,579,610 (-)NCBI
GRCh371150,547,027 - 150,552,214 (-)ENTREZGENE
HuRef1121,925,157 - 121,930,349 (-)ENTREZGENE
CHM1_11151,942,802 - 151,947,994 (-)NCBI
T2T-CHM13v2.01149,698,578 - 149,703,635 (-)NCBI
Sequence:
RefSeq Acc Id: NM_021960   ⟹   NP_068779
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381150,574,558 - 150,579,610 (-)NCBI
GRCh371150,547,027 - 150,552,214 (-)ENTREZGENE
Build 361148,813,658 - 148,818,760 (-)NCBI Archive
HuRef1121,925,157 - 121,930,349 (-)ENTREZGENE
CHM1_11151,942,802 - 151,947,994 (-)NCBI
T2T-CHM13v2.01149,698,578 - 149,703,635 (-)NCBI
Sequence:
RefSeq Acc Id: NM_182763   ⟹   NP_877495
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381150,574,558 - 150,579,610 (-)NCBI
GRCh371150,547,027 - 150,552,214 (-)ENTREZGENE
Build 361148,813,658 - 148,818,760 (-)NCBI Archive
HuRef1121,925,157 - 121,930,349 (-)ENTREZGENE
CHM1_11151,942,802 - 151,947,994 (-)NCBI
T2T-CHM13v2.01149,698,578 - 149,703,635 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001184249 (Get FASTA)   NCBI Sequence Viewer  
  NP_068779 (Get FASTA)   NCBI Sequence Viewer  
  NP_877495 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD13299 (Get FASTA)   NCBI Sequence Viewer  
  AAF15309 (Get FASTA)   NCBI Sequence Viewer  
  AAF15310 (Get FASTA)   NCBI Sequence Viewer  
  AAF15311 (Get FASTA)   NCBI Sequence Viewer  
  AAF64255 (Get FASTA)   NCBI Sequence Viewer  
  AAF64256 (Get FASTA)   NCBI Sequence Viewer  
  AAF74821 (Get FASTA)   NCBI Sequence Viewer  
  AAG00896 (Get FASTA)   NCBI Sequence Viewer  
  AAG00904 (Get FASTA)   NCBI Sequence Viewer  
  AAH17197 (Get FASTA)   NCBI Sequence Viewer  
  AAH71897 (Get FASTA)   NCBI Sequence Viewer  
  AAI07736 (Get FASTA)   NCBI Sequence Viewer  
  AAP35286 (Get FASTA)   NCBI Sequence Viewer  
  AAY68220 (Get FASTA)   NCBI Sequence Viewer  
  ACV83304 (Get FASTA)   NCBI Sequence Viewer  
  BAG35409 (Get FASTA)   NCBI Sequence Viewer  
  BAG57694 (Get FASTA)   NCBI Sequence Viewer  
  BAG59700 (Get FASTA)   NCBI Sequence Viewer  
  BAG62213 (Get FASTA)   NCBI Sequence Viewer  
  BAG65530 (Get FASTA)   NCBI Sequence Viewer  
  BAH14638 (Get FASTA)   NCBI Sequence Viewer  
  EAW53538 (Get FASTA)   NCBI Sequence Viewer  
  EAW53539 (Get FASTA)   NCBI Sequence Viewer  
  EAW53540 (Get FASTA)   NCBI Sequence Viewer  
  EAW53541 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000309973
  ENSP00000309973.3
  ENSP00000358022
  ENSP00000358022.2
  ENSP00000477624
  ENSP00000477624.1
  ENSP00000502859.1
  ENSP00000503149.1
GenBank Protein Q07820 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001184249   ⟸   NM_001197320
- Peptide Label: isoform 3
- UniProtKB: A0A087WT64 (UniProtKB/TrEMBL),   C8YZ26 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_877495   ⟸   NM_182763
- Peptide Label: isoform 2
- UniProtKB: Q07820 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_068779   ⟸   NM_021960
- Peptide Label: isoform 1
- UniProtKB: Q9UHR9 (UniProtKB/Swiss-Prot),   Q9UHR8 (UniProtKB/Swiss-Prot),   Q9UHR7 (UniProtKB/Swiss-Prot),   Q9NRQ4 (UniProtKB/Swiss-Prot),   Q9NRQ3 (UniProtKB/Swiss-Prot),   Q9HD91 (UniProtKB/Swiss-Prot),   D3DV04 (UniProtKB/Swiss-Prot),   D3DV03 (UniProtKB/Swiss-Prot),   B2R6B2 (UniProtKB/Swiss-Prot),   Q9UNJ1 (UniProtKB/Swiss-Prot),   Q07820 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000477624   ⟸   ENST00000620947
Ensembl Acc Id: ENSP00000309973   ⟸   ENST00000307940
Ensembl Acc Id: ENSP00000358022   ⟸   ENST00000369026
Ensembl Acc Id: ENSP00000502859   ⟸   ENST00000678770
Ensembl Acc Id: ENSP00000503149   ⟸   ENST00000678610
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q07820-F1-model_v2 AlphaFold Q07820 1-350 view protein structure

Promoters
RGD ID:6809626
Promoter ID:HG_ACW:4003
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid
Transcripts:MCL1.EAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 361148,815,996 - 148,816,496 (-)MPROMDB
RGD ID:6786006
Promoter ID:HG_KWN:4941
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_182763,   OTTHUMT00000084402,   OTTHUMT00000087243
Position:
Human AssemblyChrPosition (strand)Source
Build 361148,817,476 - 148,818,787 (-)MPROMDB
RGD ID:6856982
Promoter ID:EPDNEW_H1656
Type:initiation region
Name:MCL1_1
Description:MCL1, BCL2 family apoptosis regulator
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381150,579,610 - 150,579,670EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:6943 AgrOrtholog
COSMIC MCL1 COSMIC
Ensembl Genes ENSG00000143384 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000307940 ENTREZGENE
  ENST00000307940.3 UniProtKB/Swiss-Prot
  ENST00000369026 ENTREZGENE
  ENST00000369026.3 UniProtKB/Swiss-Prot
  ENST00000620947 ENTREZGENE
  ENST00000620947.4 UniProtKB/TrEMBL
  ENST00000678610.1 UniProtKB/TrEMBL
  ENST00000678770.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.437.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
GTEx ENSG00000143384 GTEx
HGNC ID HGNC:6943 ENTREZGENE
Human Proteome Map MCL1 Human Proteome Map
InterPro Apop_reg_Mc1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bcl-2_BH1-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bcl2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bcl2_BH1_motif_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bcl2_BH2_motif_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bcl2_BH3_motif_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Blc2-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Blc2_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:4170 UniProtKB/Swiss-Prot
NCBI Gene 4170 ENTREZGENE
OMIM 159552 OMIM
PANTHER PTHR11256 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11256:SF46 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Bcl-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA30688 PharmGKB
PRINTS APOPREGMCL1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BCL2FAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BCL2_FAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BCL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56854 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087WT64 ENTREZGENE, UniProtKB/TrEMBL
  A0A7I2V2W2_HUMAN UniProtKB/TrEMBL
  B2R6B2 ENTREZGENE
  C8YZ26 ENTREZGENE, UniProtKB/TrEMBL
  D3DV03 ENTREZGENE
  D3DV04 ENTREZGENE
  MCL1_HUMAN UniProtKB/Swiss-Prot
  Q03399_HUMAN UniProtKB/TrEMBL
  Q07820 ENTREZGENE
  Q9HD91 ENTREZGENE
  Q9NRQ3 ENTREZGENE
  Q9NRQ4 ENTREZGENE
  Q9UHR7 ENTREZGENE
  Q9UHR8 ENTREZGENE
  Q9UHR9 ENTREZGENE
  Q9UNJ1 ENTREZGENE
UniProt Secondary B2R6B2 UniProtKB/Swiss-Prot
  D3DV03 UniProtKB/Swiss-Prot
  D3DV04 UniProtKB/Swiss-Prot
  Q9HD91 UniProtKB/Swiss-Prot
  Q9NRQ3 UniProtKB/Swiss-Prot
  Q9NRQ4 UniProtKB/Swiss-Prot
  Q9UHR7 UniProtKB/Swiss-Prot
  Q9UHR8 UniProtKB/Swiss-Prot
  Q9UHR9 UniProtKB/Swiss-Prot
  Q9UNJ1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-29 MCL1  MCL1 apoptosis regulator, BCL2 family member    MCL1, BCL2 family apoptosis regulator  Symbol and/or name change 5135510 APPROVED
2017-03-07 MCL1  MCL1, BCL2 family apoptosis regulator    BCL2 family apoptosis regulator  Symbol and/or name change 5135510 APPROVED
2016-06-21 MCL1  BCL2 family apoptosis regulator    myeloid cell leukemia 1  Symbol and/or name change 5135510 APPROVED
2014-03-12 MCL1  myeloid cell leukemia 1    myeloid cell leukemia sequence 1 (BCL2-related)  Symbol and/or name change 5135510 APPROVED