RARG (retinoic acid receptor gamma) - Rat Genome Database

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Gene: RARG (retinoic acid receptor gamma) Homo sapiens
Analyze
Symbol: RARG
Name: retinoic acid receptor gamma
RGD ID: 735465
HGNC Page HGNC:9866
Description: Enables sequence-specific double-stranded DNA binding activity. Involved in response to retinoic acid and retinoic acid receptor signaling pathway. Located in chromatin and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: NR1B3; nuclear receptor subfamily 1 group B member 3; RAR-gamma; RARC; RARgamma; retinoic acid nuclear receptor gamma variant 1; retinoic acid nuclear receptor gamma variant 2; retinoic acid receptor, gamma
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381253,210,569 - 53,232,209 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1253,210,567 - 53,232,980 (-)Ensemblhg38GRCh38
GRCh371253,604,353 - 53,625,993 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361251,890,620 - 51,912,303 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341251,890,620 - 51,912,247NCBI
Celera1253,252,956 - 53,274,263 (-)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1250,646,458 - 50,668,146 (-)NCBIHuRef
CHM1_11253,570,785 - 53,592,447 (-)NCBICHM1_1
T2T-CHM13v2.01253,176,168 - 53,197,803 (-)NCBIT2T-CHM13v2.0
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-naphthylamine  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (EXP)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (EXP)
9-cis-retinoic acid  (EXP,ISO)
acetamide  (ISO)
acrolein  (EXP)
acrylamide  (EXP)
adapalene  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (EXP)
aldrin  (EXP)
all-trans-4-hydroxyretinoic acid  (EXP)
all-trans-4-oxoretinoic acid  (EXP)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
aristolochic acid A  (EXP)
arotinoid acid  (EXP,ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (EXP)
beta-lapachone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
carotenoid  (ISO)
chlorpyrifos  (ISO)
cisplatin  (EXP)
cyclophosphamide  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (EXP)
dibutyl phthalate  (ISO)
dieldrin  (EXP)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
doxorubicin  (EXP)
endosulfan  (EXP)
endrin  (EXP)
enilconazole  (EXP)
ethanol  (EXP)
ezetimibe  (EXP)
gentamycin  (ISO)
glycidyl methacrylate  (EXP)
griseofulvin  (ISO)
GSK-J4  (EXP)
isotretinoin  (ISO)
lipopolysaccharide  (EXP)
methamphetamine  (ISO)
methoxychlor  (ISO)
mifepristone  (EXP)
nicotine  (EXP)
orphenadrine  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
phenytoin  (ISO)
potassium chromate  (EXP)
potassium dichromate  (ISO)
quinomethionate  (EXP)
Ro 41-5253  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
sodium arsenite  (EXP)
sunitinib  (EXP)
tamibarotene  (ISO)
tazarotene  (EXP)
tazarotenic acid  (EXP)
testosterone  (ISO)
thiazoles  (EXP)
thioacetamide  (ISO)
thiram  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
tributylstannane  (EXP,ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior pattern specification  (IEA)
apoptotic process  (IEA)
bone development  (IEA,ISO)
bone morphogenesis  (IEA)
canonical Wnt signaling pathway  (TAS)
cell differentiation  (IBA)
cell population proliferation  (IEA)
cellular response to leukemia inhibitory factor  (IEA)
cellular response to retinoic acid  (IEA,ISO)
chondrocyte development  (IEA)
embryonic camera-type eye development  (IEA)
embryonic eye morphogenesis  (IEA,ISS)
embryonic hindlimb morphogenesis  (IEA,ISS)
epithelium development  (IEA)
face development  (IEA)
gland development  (IEA)
glandular epithelial cell development  (IEA)
growth plate cartilage chondrocyte growth  (IEA)
growth plate cartilage development  (IEA)
Harderian gland development  (IEA)
limb development  (IEA,ISO)
multicellular organism growth  (IEA)
negative regulation of cartilage development  (IEA)
negative regulation of cell differentiation  (IEA)
negative regulation of cell population proliferation  (ISS)
negative regulation of chondrocyte differentiation  (IEA)
negative regulation of stem cell proliferation  (IEA)
negative regulation of transcription by RNA polymerase II  (IBA,IEA,ISS)
neural tube closure  (IEA)
positive regulation of apoptotic process  (IEA,ISS)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of gene expression  (IEA)
positive regulation of programmed cell death  (IEA,ISS)
positive regulation of transcription by RNA polymerase II  (IBA,IEA,ISS)
programmed cell death  (IEA)
prostate gland epithelium morphogenesis  (IEA)
regulation of cell size  (TAS)
regulation of DNA-templated transcription  (IEA)
regulation of gene expression  (IEA)
regulation of myelination  (IEA,ISO)
regulation of myeloid cell differentiation  (IEA)
reproductive structure development  (IEA)
response to retinoic acid  (IDA,IEA)
retinoic acid receptor signaling pathway  (IBA,IDA,IEA,ISO)
stem cell proliferation  (IEA)
trachea cartilage development  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. International Union of Pharmacology. LX. Retinoic acid receptors. Germain P, etal., Pharmacol Rev. 2006 Dec;58(4):712-25.
2. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
3. Vitamin A regulation of gene expression: molecular mechanism of a prototype gene. McGrane MM J Nutr Biochem. 2007 Aug;18(8):497-508. Epub 2007 Feb 22.
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs). Rochette-Egly C and Germain P, Nucl Recept Signal. 2009 May 8;7:e005.
Additional References at PubMed
PMID:1310259   PMID:1318502   PMID:1320193   PMID:1655630   PMID:1849262   PMID:2157210   PMID:2157970   PMID:2172793   PMID:2546152   PMID:7501014   PMID:7685085   PMID:8301142  
PMID:9083083   PMID:9491782   PMID:9501913   PMID:9852056   PMID:9865725   PMID:10318855   PMID:10336495   PMID:10428834   PMID:11855864   PMID:12189556   PMID:12220491   PMID:12399530  
PMID:12477932   PMID:12554770   PMID:12665583   PMID:14603262   PMID:14657503   PMID:14691372   PMID:14705796   PMID:15383624   PMID:15489334   PMID:15604093   PMID:15635645   PMID:15734736  
PMID:15839736   PMID:16344560   PMID:16456540   PMID:17195188   PMID:17252005   PMID:17325034   PMID:17363140   PMID:17574023   PMID:17943189   PMID:18438858   PMID:18484682   PMID:18685608  
PMID:18816836   PMID:18845237   PMID:18996102   PMID:19274049   PMID:19345331   PMID:19350571   PMID:19416972   PMID:19416983   PMID:19563758   PMID:19732752   PMID:19902255   PMID:19913121  
PMID:20133701   PMID:20346360   PMID:20387030   PMID:20413580   PMID:20420906   PMID:20602615   PMID:20628086   PMID:20634891   PMID:20857416   PMID:21131358   PMID:21178008   PMID:21254357  
PMID:21401418   PMID:21873635   PMID:21923909   PMID:21988832   PMID:21990348   PMID:22362749   PMID:22901127   PMID:23518499   PMID:23798555   PMID:24050824   PMID:25036637   PMID:25510432  
PMID:26237429   PMID:27325643   PMID:27756432   PMID:28272990   PMID:28336971   PMID:28473536   PMID:28514442   PMID:28552962   PMID:28692043   PMID:28871172   PMID:29530751   PMID:29568099  
PMID:30120411   PMID:30532072   PMID:32296183   PMID:32587261   PMID:33252195   PMID:33961781   PMID:34373451   PMID:34470463   PMID:35575683   PMID:35748872   PMID:36183362   PMID:36950384  
PMID:37828659   PMID:37897947   PMID:38245869  


Genomics

Comparative Map Data
RARG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381253,210,569 - 53,232,209 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1253,210,567 - 53,232,980 (-)Ensemblhg38GRCh38
GRCh371253,604,353 - 53,625,993 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361251,890,620 - 51,912,303 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341251,890,620 - 51,912,247NCBI
Celera1253,252,956 - 53,274,263 (-)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1250,646,458 - 50,668,146 (-)NCBIHuRef
CHM1_11253,570,785 - 53,592,447 (-)NCBICHM1_1
T2T-CHM13v2.01253,176,168 - 53,197,803 (-)NCBIT2T-CHM13v2.0
Rarg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915102,143,373 - 102,165,891 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15102,143,373 - 102,165,952 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3815102,234,938 - 102,257,522 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15102,234,938 - 102,257,517 (-)Ensemblmm10GRCm38
MGSCv3715102,065,371 - 102,087,914 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3615102,062,974 - 102,085,313 (-)NCBIMGSCv36mm8
Celera15104,391,902 - 104,414,975 (-)NCBICelera
Cytogenetic Map15F2NCBI
cM Map1557.4NCBI
Rarg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87135,246,427 - 135,268,889 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7135,246,427 - 135,268,889 (-)EnsemblGRCr8
mRatBN7.27133,367,833 - 133,390,301 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7133,367,833 - 133,390,177 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7135,129,112 - 135,151,291 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07137,358,476 - 137,380,666 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07137,343,604 - 137,365,726 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,840,739 - 143,863,206 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,839,980 - 143,863,186 (-)Ensemblrn6Rnor6.0
Rnor_5.07141,637,841 - 141,660,460 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47140,991,447 - 141,014,108 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7129,801,582 - 129,823,782 (-)NCBICelera
Cytogenetic Map7q36NCBI
Rarg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955458480,070 - 501,356 (-)Ensembl
ChiLan1.0NW_004955458480,257 - 501,172 (-)NCBIChiLan1.0ChiLan1.0
RARG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21040,953,035 - 40,975,357 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11240,950,506 - 40,972,122 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01235,521,276 - 35,542,814 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11236,303,328 - 36,325,111 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1236,303,359 - 36,325,111 (+)EnsemblpanPan2panpan1.1
RARG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1271,958,432 - 1,978,471 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl271,958,204 - 1,978,476 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2744,271,142 - 44,291,835 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0271,961,941 - 1,982,664 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl271,962,558 - 1,982,661 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1271,980,967 - 2,000,875 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0271,965,173 - 1,985,840 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02744,671,821 - 44,692,522 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rarg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494562,640,418 - 62,661,874 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651210,500,622 - 10,524,824 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493651210,502,954 - 10,524,796 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RARG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl518,436,270 - 18,458,624 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1518,436,267 - 18,458,625 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2518,869,535 - 18,878,967 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RARG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11149,319,104 - 49,340,725 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1149,319,839 - 49,328,656 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037196,719,056 - 196,740,773 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rarg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249041,255,854 - 1,277,946 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in RARG
15 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12q13.13(chr12:53099658-53724525)x1 copy number loss See cases [RCV000052811] Chr12:53099658..53724525 [GRCh38]
Chr12:53493442..54118309 [GRCh37]
Chr12:51779709..52404576 [NCBI36]
Chr12:12q13.13		 pathogenic
GRCh38/hg38 12q13.13(chr12:53224024-54222450)x1 copy number loss See cases [RCV000052812] Chr12:53224024..54222450 [GRCh38]
Chr12:53617808..54616234 [GRCh37]
Chr12:51904075..52902501 [NCBI36]
Chr12:12q13.13		 pathogenic
NM_000966.5(RARG):c.1236C>T (p.Ile412=) single nucleotide variant Malignant melanoma [RCV000070061] Chr12:53211805 [GRCh38]
Chr12:53605589 [GRCh37]
Chr12:51891856 [NCBI36]
Chr12:12q13.13		 not provided
GRCh38/hg38 12q13.13(chr12:52851850-53558824)x3 copy number gain See cases [RCV000138030] Chr12:52851850..53558824 [GRCh38]
Chr12:53245634..53952608 [GRCh37]
Chr12:51531901..52238875 [NCBI36]
Chr12:12q13.13		 likely pathogenic
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33		 pathogenic
GRCh38/hg38 12q13.12-13.13(chr12:50122359-53248460)x1 copy number loss See cases [RCV000142033] Chr12:50122359..53248460 [GRCh38]
Chr12:50516142..53642244 [GRCh37]
Chr12:48802409..51928511 [NCBI36]
Chr12:12q13.12-13.13		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic|likely pathogenic
NM_000966.6(RARG):c.245C>T (p.Pro82Leu) single nucleotide variant Irido-corneo-trabecular dysgenesis [RCV000207406] Chr12:53215734 [GRCh38]
Chr12:53609518 [GRCh37]
Chr12:12q13.13		 likely benign
GRCh37/hg19 12q13.13(chr12:53421635-53645669)x3 copy number gain Breast ductal adenocarcinoma [RCV000207107] Chr12:53421635..53645669 [GRCh37]
Chr12:12q13.13		 uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
NC_000012.11:g.26370251_54361538inv inversion not specified [RCV000714265] Chr12:26370251..54361538 [GRCh37]
Chr12:12p12.1-q13.13		 uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
NM_000966.6(RARG):c.511G>A (p.Val171Met) single nucleotide variant not specified [RCV004320665] Chr12:53214571 [GRCh38]
Chr12:53608355 [GRCh37]
Chr12:12q13.13		 uncertain significance
GRCh37/hg19 12q13.13(chr12:53614278-53971802)x1 copy number loss not provided [RCV001259613] Chr12:53614278..53971802 [GRCh37]
Chr12:12q13.13		 likely pathogenic
GRCh37/hg19 12q13.13(chr12:53372321-53864490)x1 copy number loss not provided [RCV001259614] Chr12:53372321..53864490 [GRCh37]
Chr12:12q13.13		 uncertain significance
NM_000966.6(RARG):c.1280C>T (p.Ser427Leu) single nucleotide variant not provided [RCV001690475] Chr12:53211761 [GRCh38]
Chr12:53605545 [GRCh37]
Chr12:12q13.13		 benign
NM_000966.6(RARG):c.495C>G (p.Asn165Lys) single nucleotide variant not specified [RCV004078006] Chr12:53214587 [GRCh38]
Chr12:53608371 [GRCh37]
Chr12:12q13.13		 uncertain significance
GRCh37/hg19 12q13.13(chr12:53583828-53922629)x3 copy number gain not provided [RCV003484869] Chr12:53583828..53922629 [GRCh37]
Chr12:12q13.13		 uncertain significance
NM_000966.6(RARG):c.511G>C (p.Val171Leu) single nucleotide variant not specified [RCV004438521] Chr12:53214571 [GRCh38]
Chr12:53608355 [GRCh37]
Chr12:12q13.13		 uncertain significance
GRCh37/hg19 12q13.13(chr12:53502510-54256094)x3 copy number gain not specified [RCV003986989] Chr12:53502510..54256094 [GRCh37]
Chr12:12q13.13		 uncertain significance
NM_000966.6(RARG):c.383G>A (p.Arg128His) single nucleotide variant not specified [RCV004438520] Chr12:53215385 [GRCh38]
Chr12:53609169 [GRCh37]
Chr12:12q13.13		 uncertain significance
NM_000966.6(RARG):c.82G>A (p.Ala28Thr) single nucleotide variant not specified [RCV004438522] Chr12:53227464 [GRCh38]
Chr12:53621248 [GRCh37]
Chr12:12q13.13		 uncertain significance
NM_000966.6(RARG):c.490C>T (p.Arg164Trp) single nucleotide variant not specified [RCV004669602] Chr12:53214592 [GRCh38]
Chr12:53608376 [GRCh37]
Chr12:12q13.13		 uncertain significance
NM_000966.6(RARG):c.382C>T (p.Arg128Cys) single nucleotide variant not specified [RCV004860437] Chr12:53215386 [GRCh38]
Chr12:53609170 [GRCh37]
Chr12:12q13.13		 uncertain significance
NM_000966.6(RARG):c.29C>T (p.Ala10Val) single nucleotide variant not specified [RCV004860439] Chr12:53227517 [GRCh38]
Chr12:53621301 [GRCh37]
Chr12:12q13.13		 uncertain significance
NM_000966.6(RARG):c.281A>G (p.Asn94Ser) single nucleotide variant not specified [RCV004860438] Chr12:53215698 [GRCh38]
Chr12:53609482 [GRCh37]
Chr12:12q13.13		 uncertain significance
NM_000966.6(RARG):c.577G>A (p.Val193Ile) single nucleotide variant not specified [RCV004854301] Chr12:53214505 [GRCh38]
Chr12:53608289 [GRCh37]
Chr12:12q13.13		 uncertain significance
NM_000966.6(RARG):c.1015G>A (p.Gly339Arg) single nucleotide variant not specified [RCV005265635] Chr12:53213499 [GRCh38]
Chr12:53607283 [GRCh37]
Chr12:12q13.13		 uncertain significance
NM_000966.6(RARG):c.1024A>G (p.Met342Val) single nucleotide variant not specified [RCV005265636] Chr12:53213238 [GRCh38]
Chr12:53607022 [GRCh37]
Chr12:12q13.13		 uncertain significance
NM_000966.6(RARG):c.520G>C (p.Glu174Gln) single nucleotide variant not specified [RCV005265637] Chr12:53214562 [GRCh38]
Chr12:53608346 [GRCh37]
Chr12:12q13.13		 uncertain significance
NM_000966.6(RARG):c.947G>A (p.Gly316Glu) single nucleotide variant not specified [RCV005265640] Chr12:53213567 [GRCh38]
Chr12:53607351 [GRCh37]
Chr12:12q13.13		 uncertain significance
NM_000966.6(RARG):c.524G>C (p.Gly175Ala) single nucleotide variant not specified [RCV005265641] Chr12:53214558 [GRCh38]
Chr12:53608342 [GRCh37]
Chr12:12q13.13		 uncertain significance
NM_000966.6(RARG):c.29C>A (p.Ala10Glu) single nucleotide variant not specified [RCV005265638] Chr12:53227517 [GRCh38]
Chr12:53621301 [GRCh37]
Chr12:12q13.13		 uncertain significance
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR182hsa-miR-182-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19782699
MIR182hsa-miR-182-3pMirecordsexternal_infoNANA19782699

Predicted Target Of
Summary Value
Count of predictions:8479
Count of miRNA genes:1050
Interacting mature miRNAs:1342
Transcripts:ENST00000327550, ENST00000338561, ENST00000394426, ENST00000425354, ENST00000543726, ENST00000543762, ENST00000546377, ENST00000546717, ENST00000548284, ENST00000548317, ENST00000549859, ENST00000550265, ENST00000550350, ENST00000550362, ENST00000550721, ENST00000551158, ENST00000551501, ENST00000551580, ENST00000552901
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
406977154GWAS626130_Hexercise test QTL GWAS626130 (human)0.0000002exercise test125322056553220566Human
597102115GWAS1198189_Hschizophrenia, intelligence, self reported educational attainment QTL GWAS1198189 (human)1e-10schizophrenia, intelligence, self reported educational attainment125321156053211561Human
597095312GWAS1191386_Hcardiotoxicity, response to anthracycline-based chemotherapy QTL GWAS1191386 (human)6e-08cardiotoxicity, response to anthracycline-based chemotherapy125321176153211762Human
597095313GWAS1191387_Hcardiotoxicity, response to anthracycline-based chemotherapy QTL GWAS1191387 (human)8e-08cardiotoxicity, response to anthracycline-based chemotherapy125321176153211762Human
597061695GWAS1157769_Hschizophrenia QTL GWAS1157769 (human)4e-08schizophrenia125321156053211561Human
597059359GWAS1155433_Hvital capacity QTL GWAS1155433 (human)9e-09lung capacity (VT:0001942)125321800753218008Human
597112169GWAS1208243_Hcognitive function measurement QTL GWAS1208243 (human)5e-08cognitive behavior trait (VT:0010450)125321156053211561Human
597428227GWAS1524301_Hgout QTL GWAS1524301 (human)2e-09joint integrity trait (VT:0010548)125322374253223743Human

Markers in Region
STS-M38258  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371253,605,007 - 53,605,196UniSTSGRCh37
Build 361251,891,274 - 51,891,463RGDNCBI36
Celera1253,253,610 - 53,253,799RGD
Cytogenetic Map12q13UniSTS
HuRef1250,647,115 - 50,647,304UniSTS
GeneMap99-GB4 RH Map12227.66UniSTS
NCBI RH Map12439.9UniSTS
WI-18980  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371253,605,060 - 53,605,327UniSTSGRCh37
Build 361251,891,327 - 51,891,594RGDNCBI36
Celera1253,253,663 - 53,253,930RGD
Cytogenetic Map12q13UniSTS
HuRef1250,647,168 - 50,647,435UniSTS
GeneMap99-GB4 RH Map12227.97UniSTS
Whitehead-RH Map12315.7UniSTS
NCBI RH Map12442.2UniSTS
GDB:384836  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371253,604,773 - 53,604,906UniSTSGRCh37
Build 361251,891,040 - 51,891,173RGDNCBI36
Celera1253,253,376 - 53,253,509RGD
Cytogenetic Map12q13UniSTS
HuRef1250,646,881 - 50,647,014UniSTS
Rarg  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371253,609,151 - 53,609,517UniSTSGRCh37
Build 361251,895,418 - 51,895,784RGDNCBI36
Celera1253,257,754 - 53,258,120RGD
HuRef1250,651,259 - 50,651,625UniSTS
RARG_247  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371253,604,352 - 53,605,209UniSTSGRCh37
Build 361251,890,619 - 51,891,476RGDNCBI36
Celera1253,252,955 - 53,253,812RGD
HuRef1250,646,460 - 50,647,317UniSTS
GDB:677651  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371253,604,430 - 53,604,756UniSTSGRCh37
Build 361251,890,697 - 51,891,023RGDNCBI36
Celera1253,253,033 - 53,253,359RGD
Cytogenetic Map12q13UniSTS
HuRef1250,646,538 - 50,646,864UniSTS
AFM310yh9  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371253,606,442 - 53,606,679UniSTSGRCh37
Build 361251,892,709 - 51,892,946RGDNCBI36
Celera1253,255,045 - 53,255,282RGD
Cytogenetic Map12q13UniSTS
HuRef1250,648,550 - 50,648,787UniSTS
Whitehead-RH Map12326.0UniSTS
NCBI RH Map12442.2UniSTS
GDB:376723  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12q13UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2438 2788 2251 4973 1726 2351 6 624 1943 465 2270 7298 6464 53 3733 1 852 1744 1617 175 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_029822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001042728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001243730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001243731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001243732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024449112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024449113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024449114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB307689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC021072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC073573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH009956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH010076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ250835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK297023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK297110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK297277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK297801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK316259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL701206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW002722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC019098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC064524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC072462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC093727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC093729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC098421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO394652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS542443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA436501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA552724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC294855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ692828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ692829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT583884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L12060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M24857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M32074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M38258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M57707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X57280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000338561   ⟹   ENSP00000343698
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1253,211,331 - 53,220,259 (-)Ensembl
Ensembl Acc Id: ENST00000394426   ⟹   ENSP00000377947
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1253,210,567 - 53,232,256 (-)Ensembl
Ensembl Acc Id: ENST00000425354   ⟹   ENSP00000388510
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1253,210,569 - 53,232,209 (-)Ensembl
Ensembl Acc Id: ENST00000543726   ⟹   ENSP00000444335
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1253,211,393 - 53,220,413 (-)Ensembl
Ensembl Acc Id: ENST00000543762
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1253,211,414 - 53,232,232 (-)Ensembl
Ensembl Acc Id: ENST00000546377
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1253,227,608 - 53,232,222 (-)Ensembl
Ensembl Acc Id: ENST00000546717   ⟹   ENSP00000454417
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1253,227,374 - 53,232,214 (-)Ensembl
Ensembl Acc Id: ENST00000548284
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1253,215,374 - 53,220,084 (-)Ensembl
Ensembl Acc Id: ENST00000548317
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1253,213,940 - 53,215,352 (-)Ensembl
Ensembl Acc Id: ENST00000549859
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1253,227,635 - 53,232,188 (-)Ensembl
Ensembl Acc Id: ENST00000550265
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1253,213,237 - 53,220,377 (-)Ensembl
Ensembl Acc Id: ENST00000550350
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1253,227,558 - 53,232,216 (-)Ensembl
Ensembl Acc Id: ENST00000550362   ⟹   ENSP00000454385
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1253,227,500 - 53,232,980 (-)Ensembl
Ensembl Acc Id: ENST00000550721
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1253,227,556 - 53,232,921 (-)Ensembl
Ensembl Acc Id: ENST00000551158   ⟹   ENSP00000454604
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1253,227,448 - 53,232,570 (-)Ensembl
Ensembl Acc Id: ENST00000551501
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1253,227,598 - 53,232,231 (-)Ensembl
Ensembl Acc Id: ENST00000551580
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1253,214,094 - 53,214,857 (-)Ensembl
Ensembl Acc Id: ENST00000552901
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1253,231,168 - 53,232,586 (-)Ensembl
RefSeq Acc Id: NM_000966   ⟹   NP_000957
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381253,210,569 - 53,232,209 (-)NCBI
GRCh371253,604,350 - 53,626,040 (-)NCBI
Build 361251,890,620 - 51,912,303 (-)NCBI Archive
HuRef1250,646,458 - 50,668,146 (-)NCBI
CHM1_11253,570,785 - 53,592,447 (-)NCBI
T2T-CHM13v2.01253,176,168 - 53,197,803 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001042728   ⟹   NP_001036193
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381253,210,569 - 53,220,362 (-)NCBI
GRCh371253,604,350 - 53,626,040 (-)NCBI
Build 361251,890,620 - 51,900,417 (-)NCBI Archive
HuRef1250,646,458 - 50,668,146 (-)NCBI
CHM1_11253,570,785 - 53,580,630 (-)NCBI
T2T-CHM13v2.01253,176,168 - 53,185,961 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001243730   ⟹   NP_001230659
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381253,210,569 - 53,232,209 (-)NCBI
GRCh371253,604,350 - 53,626,040 (-)NCBI
HuRef1250,646,458 - 50,668,146 (-)NCBI
CHM1_11253,570,785 - 53,592,447 (-)NCBI
T2T-CHM13v2.01253,176,168 - 53,197,803 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001243731   ⟹   NP_001230660
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381253,210,569 - 53,232,209 (-)NCBI
GRCh371253,604,350 - 53,626,040 (-)NCBI
HuRef1250,646,458 - 50,668,146 (-)NCBI
CHM1_11253,570,785 - 53,592,447 (-)NCBI
T2T-CHM13v2.01253,176,168 - 53,197,803 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001243732   ⟹   NP_001230661
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381253,210,569 - 53,220,362 (-)NCBI
GRCh371253,604,350 - 53,626,040 (-)NCBI
HuRef1250,646,458 - 50,668,146 (-)NCBI
CHM1_11253,570,785 - 53,580,630 (-)NCBI
T2T-CHM13v2.01253,176,168 - 53,185,961 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_000957 (Get FASTA)   NCBI Sequence Viewer  
  NP_001036193 (Get FASTA)   NCBI Sequence Viewer  
  NP_001230659 (Get FASTA)   NCBI Sequence Viewer  
  NP_001230660 (Get FASTA)   NCBI Sequence Viewer  
  NP_001230661 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA52692 (Get FASTA)   NCBI Sequence Viewer  
  AAA60253 (Get FASTA)   NCBI Sequence Viewer  
  AAA60254 (Get FASTA)   NCBI Sequence Viewer  
  AAA63254 (Get FASTA)   NCBI Sequence Viewer  
  AAG41594 (Get FASTA)   NCBI Sequence Viewer  
  AAH93727 (Get FASTA)   NCBI Sequence Viewer  
  AAH93729 (Get FASTA)   NCBI Sequence Viewer  
  AAK07421 (Get FASTA)   NCBI Sequence Viewer  
  ADZ17339 (Get FASTA)   NCBI Sequence Viewer  
  ADZ17340 (Get FASTA)   NCBI Sequence Viewer  
  BAF83277 (Get FASTA)   NCBI Sequence Viewer  
  BAH02280 (Get FASTA)   NCBI Sequence Viewer  
  BAH12478 (Get FASTA)   NCBI Sequence Viewer  
  BAH12500 (Get FASTA)   NCBI Sequence Viewer  
  BAH12537 (Get FASTA)   NCBI Sequence Viewer  
  BAH12670 (Get FASTA)   NCBI Sequence Viewer  
  BAH13399 (Get FASTA)   NCBI Sequence Viewer  
  BAH14630 (Get FASTA)   NCBI Sequence Viewer  
  CAA40548 (Get FASTA)   NCBI Sequence Viewer  
  CAB60726 (Get FASTA)   NCBI Sequence Viewer  
  CAM91171 (Get FASTA)   NCBI Sequence Viewer  
  EAW96676 (Get FASTA)   NCBI Sequence Viewer  
  EAW96677 (Get FASTA)   NCBI Sequence Viewer  
  EAW96678 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000343698
  ENSP00000343698.5
  ENSP00000377947
  ENSP00000377947.2
  ENSP00000388510
  ENSP00000388510.2
  ENSP00000444335
  ENSP00000444335.1
GenBank Protein P13631 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_000957   ⟸   NM_000966
- Peptide Label: isoform 1
- UniProtKB: Q9H1I3 (UniProtKB/Swiss-Prot),   Q9BYX8 (UniProtKB/Swiss-Prot),   Q52LZ8 (UniProtKB/Swiss-Prot),   Q15281 (UniProtKB/Swiss-Prot),   P22932 (UniProtKB/Swiss-Prot),   J3KNP6 (UniProtKB/Swiss-Prot),   B7ZAE4 (UniProtKB/Swiss-Prot),   B7Z4F1 (UniProtKB/Swiss-Prot),   B7Z492 (UniProtKB/Swiss-Prot),   Q9UJ38 (UniProtKB/Swiss-Prot),   P13631 (UniProtKB/Swiss-Prot),   A8K3H3 (UniProtKB/TrEMBL),   B7Z4T4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001036193   ⟸   NM_001042728
- Peptide Label: isoform 2
- UniProtKB: F1D8P1 (UniProtKB/TrEMBL),   B7Z4T4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001230660   ⟸   NM_001243731
- Peptide Label: isoform 5
- UniProtKB: B7Z4B4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001230659   ⟸   NM_001243730
- Peptide Label: isoform 4
- UniProtKB: B7Z4B4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001230661   ⟸   NM_001243732
- Peptide Label: isoform 3
- UniProtKB: P13631 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000388510   ⟸   ENST00000425354
Ensembl Acc Id: ENSP00000444335   ⟸   ENST00000543726
Ensembl Acc Id: ENSP00000454417   ⟸   ENST00000546717
Ensembl Acc Id: ENSP00000343698   ⟸   ENST00000338561
Ensembl Acc Id: ENSP00000454385   ⟸   ENST00000550362
Ensembl Acc Id: ENSP00000454604   ⟸   ENST00000551158
Ensembl Acc Id: ENSP00000377947   ⟸   ENST00000394426
Protein Domains
NR LBD   Nuclear receptor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P13631-F1-model_v2 AlphaFold P13631 1-454 view protein structure

Promoters
RGD ID:6790430
Promoter ID:HG_KWN:15746
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell
Transcripts:OTTHUMT00000109404
Position:
Human AssemblyChrPosition (strand)Source
Build 361251,896,516 - 51,897,016 (-)MPROMDB
RGD ID:6790424
Promoter ID:HG_KWN:15747
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid
Transcripts:NM_001042728
Position:
Human AssemblyChrPosition (strand)Source
Build 361251,900,266 - 51,901,407 (-)MPROMDB
RGD ID:6790425
Promoter ID:HG_KWN:15748
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3
Transcripts:NM_000966,   UC001SCF.1,   UC001SCG.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361251,912,066 - 51,912,977 (-)MPROMDB
RGD ID:7224087
Promoter ID:EPDNEW_H17789
Type:multiple initiation site
Name:RARG_3
Description:retinoic acid receptor gamma
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H17791  EPDNEW_H17790  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381253,220,042 - 53,220,102EPDNEW
RGD ID:7224091
Promoter ID:EPDNEW_H17790
Type:initiation region
Name:RARG_2
Description:retinoic acid receptor gamma
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H17789  EPDNEW_H17791  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381253,220,349 - 53,220,409EPDNEW
RGD ID:7224089
Promoter ID:EPDNEW_H17791
Type:initiation region
Name:RARG_1
Description:retinoic acid receptor gamma
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H17789  EPDNEW_H17790  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381253,232,188 - 53,232,248EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9866 AgrOrtholog
COSMIC RARG COSMIC
Ensembl Genes ENSG00000172819 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000338561 ENTREZGENE
  ENST00000338561.9 UniProtKB/Swiss-Prot
  ENST00000394426 ENTREZGENE
  ENST00000394426.5 UniProtKB/Swiss-Prot
  ENST00000425354 ENTREZGENE
  ENST00000425354.7 UniProtKB/Swiss-Prot
  ENST00000543726 ENTREZGENE
  ENST00000543726.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot
  3.30.50.10 UniProtKB/Swiss-Prot
GTEx ENSG00000172819 GTEx
HGNC ID HGNC:9866 ENTREZGENE
Human Proteome Map RARG Human Proteome Map
InterPro NHR-like_dom_sf UniProtKB/Swiss-Prot
  NR_DBD_RAR UniProtKB/Swiss-Prot
  NR_LBD_RAR UniProtKB/Swiss-Prot
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot
  Retinoic_acid_rcpt UniProtKB/Swiss-Prot
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot
  Znf_NHR/GATA UniProtKB/Swiss-Prot
KEGG Report hsa:5916 UniProtKB/Swiss-Prot
NCBI Gene 5916 ENTREZGENE
OMIM 180190 OMIM
PANTHER NUCLEAR HORMONE RECEPTOR UniProtKB/Swiss-Prot
  RETINOIC ACID RECEPTOR GAMMA UniProtKB/Swiss-Prot
Pfam Hormone_recep UniProtKB/Swiss-Prot
  zf-C4 UniProtKB/Swiss-Prot
PharmGKB PA34227 PharmGKB
PRINTS RETNOICACIDR UniProtKB/Swiss-Prot
  STRDHORMONER UniProtKB/Swiss-Prot
  STROIDFINGER UniProtKB/Swiss-Prot
PROSITE NR_LBD UniProtKB/Swiss-Prot
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot
SMART HOLI UniProtKB/Swiss-Prot
  ZnF_C4 UniProtKB/Swiss-Prot
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot
  SSF48508 UniProtKB/Swiss-Prot
UniProt A8K3H3 ENTREZGENE, UniProtKB/TrEMBL
  B7Z492 ENTREZGENE
  B7Z4B4 ENTREZGENE, UniProtKB/TrEMBL
  B7Z4F1 ENTREZGENE
  B7Z4T4 ENTREZGENE, UniProtKB/TrEMBL
  B7ZAE4 ENTREZGENE
  F1D8P1 ENTREZGENE, UniProtKB/TrEMBL
  H3BMH6_HUMAN UniProtKB/TrEMBL
  H3BMK1_HUMAN UniProtKB/TrEMBL
  H3BMY6_HUMAN UniProtKB/TrEMBL
  J3KNP6 ENTREZGENE
  P13631 ENTREZGENE
  P22932 ENTREZGENE
  Q15281 ENTREZGENE
  Q52LZ8 ENTREZGENE
  Q9BYX8 ENTREZGENE
  Q9BZI0_HUMAN UniProtKB/TrEMBL
  Q9H1I3 ENTREZGENE
  Q9UJ38 ENTREZGENE
  RARG_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary B7Z492 UniProtKB/Swiss-Prot
  B7Z4F1 UniProtKB/Swiss-Prot
  B7ZAE4 UniProtKB/Swiss-Prot
  J3KNP6 UniProtKB/Swiss-Prot
  P22932 UniProtKB/Swiss-Prot
  Q15281 UniProtKB/Swiss-Prot
  Q52LZ8 UniProtKB/Swiss-Prot
  Q9BYX8 UniProtKB/Swiss-Prot
  Q9H1I3 UniProtKB/Swiss-Prot
  Q9UJ38 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-02 RARG  retinoic acid receptor gamma    retinoic acid receptor, gamma  Symbol and/or name change 5135510 APPROVED