Gpx5 (glutathione peroxidase 5) - Rat Genome Database

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Gene: Gpx5 (glutathione peroxidase 5) Mus musculus
Analyze
Symbol: Gpx5
Name: glutathione peroxidase 5
RGD ID: 735451
MGI Page MGI
Description: Predicted to enable glutathione peroxidase activity. Acts upstream of or within cellular response to oxidative stress. Located in extracellular space and sperm plasma membrane. Is expressed in several structures, including male reproductive gland or organ and placenta. Orthologous to human GPX5 (glutathione peroxidase 5).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A; Arep; arMEP24; AV379049; EGLP; epididymal secretory glutathione peroxidase; epididymis-specific glutathione peroxidase-like protein; GPx-5; GSHPx-5; lysosomal trafficking regulator, long splice form; major androgen-regulated protein; MGC124090; MGC124091; MGC124177
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391321,470,599 - 21,476,897 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1321,470,599 - 21,476,901 (-)EnsemblGRCm39 Ensembl
GRCm381321,286,429 - 21,292,727 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1321,286,429 - 21,292,731 (-)EnsemblGRCm38mm10GRCm38
MGSCv371321,378,298 - 21,384,555 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361321,293,898 - 21,300,151 (-)NCBIMGSCv36mm8
Celera1321,553,579 - 21,559,835 (-)NCBICelera
Cytogenetic Map13A3.1NCBI
cM Map137.73NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1787466   PMID:1913244   PMID:2263479   PMID:2322385   PMID:7929449   PMID:8469239   PMID:8566787   PMID:9011320   PMID:9035686   PMID:9110319   PMID:9175627   PMID:9444656  
PMID:9640275   PMID:10349636   PMID:10645275   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12211066   PMID:12477932   PMID:14681479   PMID:16141072   PMID:16141073   PMID:18577359  
PMID:18762024   PMID:19303412   PMID:19546506   PMID:21267068   PMID:21873635   PMID:22719900   PMID:24194600   PMID:27317670   PMID:32270769   PMID:32325033   PMID:38355793   PMID:38666419  


Genomics

Comparative Map Data
Gpx5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391321,470,599 - 21,476,897 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1321,470,599 - 21,476,901 (-)EnsemblGRCm39 Ensembl
GRCm381321,286,429 - 21,292,727 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1321,286,429 - 21,292,731 (-)EnsemblGRCm38mm10GRCm38
MGSCv371321,378,298 - 21,384,555 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361321,293,898 - 21,300,151 (-)NCBIMGSCv36mm8
Celera1321,553,579 - 21,559,835 (-)NCBICelera
Cytogenetic Map13A3.1NCBI
cM Map137.73NCBI
GPX5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38628,525,881 - 28,534,955 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl628,525,881 - 28,534,955 (+)EnsemblGRCh38hg38GRCh38
GRCh37628,493,658 - 28,502,732 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36628,601,768 - 28,609,923 (+)NCBINCBI36Build 36hg18NCBI36
Build 34628,601,767 - 28,609,923NCBI
Celera630,100,218 - 30,109,121 (+)NCBICelera
Cytogenetic Map6p22.1NCBI
HuRef628,300,120 - 28,309,014 (+)NCBIHuRef
CHM1_1628,496,188 - 28,505,099 (+)NCBICHM1_1
T2T-CHM13v2.0628,397,310 - 28,406,348 (+)NCBIT2T-CHM13v2.0
Gpx5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81748,131,853 - 48,138,801 (+)NCBIGRCr8
mRatBN7.21743,436,126 - 43,443,074 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1743,416,340 - 43,443,074 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1745,493,484 - 45,500,432 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01750,252,586 - 50,259,534 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01744,743,174 - 44,750,131 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01745,508,657 - 45,518,686 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1745,467,015 - 45,518,686 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01757,952,807 - 57,962,120 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.11751,091,844 - 51,098,176 (+)NCBI
Celera1753,035,706 - 53,042,631 (-)NCBICelera
Cytogenetic Map17q11NCBI
GPX5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2543,153,860 - 43,162,096 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1639,154,800 - 39,163,014 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0628,340,291 - 28,348,504 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1629,010,528 - 29,018,737 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl629,010,528 - 29,018,737 (+)Ensemblpanpan1.1panPan2
GPX5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13525,653,627 - 25,662,490 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3525,653,615 - 25,662,490 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3525,512,937 - 25,521,120 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03525,952,095 - 25,960,969 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3525,952,083 - 25,960,969 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13525,615,767 - 25,624,631 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03525,671,318 - 25,679,525 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03527,140,044 - 27,148,915 (+)NCBIUU_Cfam_GSD_1.0
Gpx5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494628,952,020 - 28,961,691 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936914487,163 - 496,465 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPX5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl722,291,986 - 22,300,727 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1722,289,432 - 22,300,727 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2724,233,520 - 24,244,829 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPX5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11744,027,538 - 44,037,304 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1744,028,543 - 44,036,686 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604428,225,741 - 28,234,766 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Gpx5
228 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:620
Count of miRNA genes:249
Interacting mature miRNAs:260
Transcripts:ENSMUST00000004456, ENSMUST00000110491
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10045625Heal23_mwound healing/regeneration 23 (mouse)Not determined13347761237477820Mouse
10402494Igmsc1_mimmunoglobulin M secreting cells 1 (mouse)Not determined131716854544918560Mouse
13463469Gssq1_mglomerulosclerosis severity QTL 1 (mouse)131906090853061050Mouse
10045624Heal24_mwound healing/regeneration (mouse)Not determined13347761237477820Mouse
12880423V25Dq7_mvitamin D inactive form serum level QTL 7 (mouse)131958398353583983Mouse
1357591Tesq1_mtestis weight QTL 1 (mouse)Not determined132061551255720517Mouse
1301367Twq1_mtestis weight QTL 1 (mouse)Not determined13361551237615672Mouse
1301015Sysbp2_msystolic blood pressure 2 (mouse)Not determined132047761259821605Mouse
1558898Hpi1_mhapatic PMN infiltration 1 (mouse)Not determined13441402553101640Mouse
4142009Pregq3_mpregnancy QTL 3 (mouse)Not determined132061551272385189Mouse
10449140Eosn2_meosinophil differential 2 (mouse)1322131134221311Mouse
1301880Hypt_mhypertension (mouse)Not determined131815679252156924Mouse
10045618Heal17_mwound healing/regeneration 17 (mouse)Not determined132074693954747056Mouse
1301661Tshp13_mtooth shape 13 (mouse)Not determined13123454672Mouse
15039338Nmrs34_mNAFLD-associated magnetic resonance shift 34 (mouse)1322131134221311Mouse
1301890Adip7_madiposity 7 (mouse)Not determined13123454672Mouse
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13395000076048119Mouse
1301984Pbd2_mpeak bone density 2 (mouse)Not determined131718950838947406Mouse
1301255Cd4ts6_mCD4 T cell subset 6 (mouse)Not determined1316854534168684Mouse
1301733Heal3_mwound healing/regeneration 3 (mouse)Not determined13368020037680343Mouse
1301227Skull19_mskull morphology 19 (mouse)Not determined13123454672Mouse
1301455Bmd3_mbone mineral density 3 (mouse)Not determined13347761237477820Mouse
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse

Markers in Region
AV379049  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381321,287,040 - 21,287,122UniSTSGRCm38
MGSCv371321,378,909 - 21,378,991UniSTSGRCm37
Celera1321,554,186 - 21,554,268UniSTS
Cytogenetic Map13A2-A4UniSTS
Whitehead/MRC_RH13259.17UniSTS
D13Mit17  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381321,293,266 - 21,293,433UniSTSGRCm38
MGSCv371321,385,135 - 21,385,302UniSTSGRCm37
Celera1321,560,415 - 21,560,566UniSTS
Cytogenetic Map13A2-A4UniSTS
cM Map138.0UniSTS
Whitehead Genetic133.3UniSTS
Whitehead/MRC_RH13260.88UniSTS
Whitehead_YAC13 UniSTS
Gpx5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13A2-A4UniSTS
Cytogenetic Map13A2-A4UniSTS
Cytogenetic Map13A2-A4UniSTS
Cytogenetic Map13A2-A4UniSTS
cM Map138.0UniSTS
Gpx5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13A2-A4UniSTS
cM Map138.0UniSTS
Gpx5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13A2-A4UniSTS
Gpx5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13A2-A4UniSTS
Gpx5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13A2-A4UniSTS
Gpx5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13A2-A4UniSTS
Gpx5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13A2-A4UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000110491   ⟹   ENSMUSP00000106117
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1321,470,599 - 21,476,901 (-)Ensembl
GRCm38.p6 Ensembl1321,286,429 - 21,292,731 (-)Ensembl
RefSeq Acc Id: NM_010343   ⟹   NP_034473
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391321,470,599 - 21,476,856 (-)NCBI
GRCm381321,286,429 - 21,292,686 (-)NCBI
MGSCv371321,378,298 - 21,384,555 (-)RGD
Celera1321,553,579 - 21,559,835 (-)RGD
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011244283   ⟹   XP_011242585
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391321,472,912 - 21,476,897 (-)NCBI
GRCm381321,288,742 - 21,292,727 (-)NCBI
Sequence:
RefSeq Acc Id: NP_034473   ⟸   NM_010343
- Peptide Label: precursor
- UniProtKB: E9QK84 (UniProtKB/Swiss-Prot),   P21765 (UniProtKB/Swiss-Prot),   Q496Q2 (UniProtKB/TrEMBL),   Q8CDQ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011242585   ⟸   XM_011244283
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSMUSP00000106117   ⟸   ENSMUST00000110491

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21765-F1-model_v2 AlphaFold P21765 1-221 view protein structure

Promoters
RGD ID:8679702
Promoter ID:EPDNEW_M17877
Type:initiation region
Name:Gpx5_1
Description:Mus musculus glutathione peroxidase 5 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381321,292,695 - 21,292,755EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104886 AgrOrtholog
Ensembl Genes ENSMUSG00000004344 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000110491 ENTREZGENE
  ENSMUST00000110491.9 UniProtKB/Swiss-Prot
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Glutathione_peroxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPX_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPX_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14780 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:104886 ENTREZGENE
NCBI Gene 14780 ENTREZGENE
PANTHER EPIDIDYMAL SECRETORY GLUTATHIONE PEROXIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11592 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GSHPx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gpx5 PhenoGen
PIRSF Glutathion_perox UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS GLUTPROXDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GLUTATHIONE_PEROXID_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLUTATHIONE_PEROXID_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLUTATHIONE_PEROXID_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E9QK84 ENTREZGENE
  GPX5_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q496Q2 ENTREZGENE, UniProtKB/TrEMBL
  Q8CC60_MOUSE UniProtKB/TrEMBL
  Q8CDQ5 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary E9QK84 UniProtKB/Swiss-Prot