Atp2b1 (ATPase, Ca++ transporting, plasma membrane 1) - Rat Genome Database

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Gene: Atp2b1 (ATPase, Ca++ transporting, plasma membrane 1) Mus musculus
Analyze
Symbol: Atp2b1
Name: ATPase, Ca++ transporting, plasma membrane 1
RGD ID: 735441
MGI Page MGI
Description: Predicted to enable several functions, including ATP hydrolysis activity; P-type calcium transporter activity; and PDZ domain binding activity. Involved in several processes, including positive regulation of bone mineralization; regulation of cytosolic calcium ion concentration; and regulation of vascular associated smooth muscle contraction. Located in basolateral plasma membrane; immunological synapse; and synaptic vesicle membrane. Is active in glutamatergic synapse; photoreceptor ribbon synapse; and presynaptic membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Used to study frontotemporal dementia and frontotemporal dementia and/or amyotrophic lateral sclerosis 7. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 66. Orthologous to human ATP2B1 (ATPase plasma membrane Ca2+ transporting 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2810442I22Rik; E130111D10Rik; plasma membrane calcium ATPase; plasma membrane calcium ATPase 1; plasma membrane calcium pump; plasma membrane calcium-transporting ATPase 1; PMC; Pmca1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391098,750,243 - 98,862,005 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1098,750,268 - 98,862,005 (+)EnsemblGRCm39 Ensembl
GRCm381098,914,630 - 99,026,143 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1098,914,406 - 99,026,143 (+)EnsemblGRCm38mm10GRCm38
MGSCv371098,377,786 - 98,488,777 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361098,344,858 - 98,453,480 (+)NCBIMGSCv36mm8
Celera10100,886,627 - 100,998,171 (+)NCBICelera
Cytogenetic Map10C3NCBI
cM Map1050.97NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,6-tribromophenol  (ISO)
2,6-dinitrotoluene  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-tert-Octylphenol  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
aminoguanidine  (ISO)
amitrole  (ISO)
antimony(0)  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
Azoxymethane  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bucladesine  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calciol  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
chromium atom  (ISO)
chromium(6+)  (EXP)
cisplatin  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (EXP,ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
disulfiram  (ISO)
diuron  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
ethanol  (EXP,ISO)
FR900359  (ISO)
gallic acid  (ISO)
gentamycin  (ISO)
gold atom  (EXP)
gold(0)  (EXP)
irinotecan  (ISO)
isoflavones  (ISO)
ivermectin  (ISO)
lipopolysaccharide  (ISO)
lycopene  (EXP)
medroxyprogesterone acetate  (ISO)
melphalan  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
miconazole  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-D-aspartic acid  (EXP)
N-nitrosodimethylamine  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
p-tert-Amylphenol  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (EXP,ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
serpentine asbestos  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (ISO)
Soman  (ISO)
streptozocin  (EXP)
succimer  (EXP)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP)
tetrahydropalmatine  (ISO)
thapsigargin  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triptonide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
tungsten  (EXP)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vinclozolin  (ISO)
zinc oxide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal auditory brainstem response  (IEA)
abnormal calcium ion homeostasis  (IAGP)
abnormal epididymis morphology  (IEA)
abnormal exploration in a new environment  (IAGP)
abnormal gait  (IAGP)
abnormal muscle electrophysiology  (IAGP)
abnormal neuromuscular synapse morphology  (IAGP)
abnormal sciatic nerve morphology  (IAGP)
abnormal social investigation  (IAGP)
abnormal urine phosphate level  (IAGP)
abnormal vibrissa morphology  (IEA)
absent primitive endoderm  (IEA)
absent trophectoderm  (IEA)
absent vibrissae  (IEA)
astrocytosis  (IAGP)
decreased anxiety-related response  (IAGP)
decreased birth body size  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral density  (IAGP)
decreased bone mineral density of femur  (IAGP)
decreased bone mineralization  (IAGP)
decreased circulating calcium level  (IEA)
decreased intestinal calcium absorption  (IAGP)
decreased urine calcium level  (IAGP)
decreased vasoconstriction  (IAGP)
decreased vertical activity  (IAGP)
embryonic lethality before implantation, complete penetrance  (IEA)
embryonic lethality prior to organogenesis  (IEA)
enlarged epididymis  (IEA)
gliosis  (IAGP)
head tossing  (IAGP)
hindlimb paralysis  (IAGP)
impaired coordination  (IAGP)
impaired righting response  (IAGP)
increased food intake  (IAGP)
increased grooming behavior  (IAGP)
increased mean systemic arterial blood pressure  (IAGP)
increased stereotypic behavior  (IAGP)
increased systemic arterial diastolic blood pressure  (IAGP)
increased systemic arterial systolic blood pressure  (IAGP)
increased vasoconstriction  (IAGP)
increased vertical stereotypic behavior  (IAGP)
jerky movement  (IAGP)
limb grasping  (IAGP)
low sweet preference  (IAGP)
muscle fasciculation  (IAGP)
neuronal cytoplasmic inclusions  (IAGP)
paralysis  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
preweaning lethality, incomplete penetrance  (IEA)
short stride length  (IAGP)
tremors  (IAGP)
weakness  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Calcium pumps in health and disease. Brini M and Carafoli E, Physiol Rev. 2009 Oct;89(4):1341-78. doi: 10.1152/physrev.00032.2008.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. MGD IEA MGD IEA
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. Mouse MP Annotation Import Pipeline RGD automated import pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Prefrontal cortex AMPA receptor plasticity is crucial for cue-induced relapse to heroin-seeking. Van den Oever MC, etal., Nat Neurosci. 2008 Sep;11(9):1053-8. doi: 10.1038/nn.2165.
11. Disrupted placental vitamin D metabolism and calcium signaling in gestational diabetes and pre-eclampsia patients. Varshney S, etal., Endocrine. 2023 Apr;80(1):191-200. doi: 10.1007/s12020-022-03272-9. Epub 2022 Dec 8.
12. [Effects of ANP upon ion pump activity and gene expression in aortic smooth muscle cells from spontaneously hypertensive rats]. Zhang GH, etal., Zhonghua Yi Xue Za Zhi. 2009 Nov 3;89(40):2862-6.
Additional References at PubMed
PMID:7840630   PMID:8889548   PMID:10349636   PMID:10362770   PMID:10434059   PMID:10512203   PMID:10577388   PMID:10951186   PMID:11042159   PMID:11076861   PMID:11387227   PMID:11544199  
PMID:12060584   PMID:12209837   PMID:12477932   PMID:12520002   PMID:12660151   PMID:12767889   PMID:12904583   PMID:14681479   PMID:14691545   PMID:15133509   PMID:15178683   PMID:15336967  
PMID:15741244   PMID:15840001   PMID:16141072   PMID:16141073   PMID:16182275   PMID:16291816   PMID:16352659   PMID:16512683   PMID:16735509   PMID:16956963   PMID:16959763   PMID:17938178  
PMID:17967808   PMID:18258656   PMID:18799693   PMID:19075228   PMID:19233278   PMID:20133672   PMID:20717922   PMID:21677750   PMID:21873635   PMID:22183401   PMID:22311909   PMID:22456337  
PMID:23266958   PMID:23413890   PMID:23460639   PMID:23666421   PMID:24194600   PMID:24805951   PMID:25044020   PMID:25737280   PMID:26392310   PMID:27329763   PMID:27626380   PMID:28378742  
PMID:28611155   PMID:28795531   PMID:28827723   PMID:29023784   PMID:29046519   PMID:29950683   PMID:30550785   PMID:30562941   PMID:30786075   PMID:30862855   PMID:31837425   PMID:32155320  
PMID:32325033   PMID:32554809   PMID:32581705   PMID:33098669   PMID:34321999   PMID:34948386   PMID:35926724   PMID:36130203   PMID:36293380   PMID:36674959   PMID:37142655   PMID:37839992  
PMID:38187761   PMID:38355793   PMID:38507609   PMID:39366945  


Genomics

Comparative Map Data
Atp2b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391098,750,243 - 98,862,005 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1098,750,268 - 98,862,005 (+)EnsemblGRCm39 Ensembl
GRCm381098,914,630 - 99,026,143 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1098,914,406 - 99,026,143 (+)EnsemblGRCm38mm10GRCm38
MGSCv371098,377,786 - 98,488,777 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361098,344,858 - 98,453,480 (+)NCBIMGSCv36mm8
Celera10100,886,627 - 100,998,171 (+)NCBICelera
Cytogenetic Map10C3NCBI
cM Map1050.97NCBI
ATP2B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381289,588,049 - 89,709,366 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1289,588,049 - 89,709,366 (-)EnsemblGRCh38hg38GRCh38
GRCh371289,981,826 - 90,103,143 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361288,505,957 - 88,573,975 (-)NCBINCBI36Build 36hg18NCBI36
Build 341288,484,295 - 88,552,312NCBI
Celera1289,653,490 - 89,721,509 (-)NCBICelera
Cytogenetic Map12q21.33NCBI
HuRef1287,047,680 - 87,115,698 (-)NCBIHuRef
CHM1_11289,946,885 - 90,014,891 (-)NCBICHM1_1
T2T-CHM13v2.01289,569,850 - 89,691,243 (-)NCBIT2T-CHM13v2.0
Atp2b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8735,622,267 - 35,731,904 (+)NCBIGRCr8
mRatBN7.2733,735,595 - 33,845,226 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl733,735,871 - 33,843,295 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx735,724,169 - 35,833,598 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0737,905,923 - 38,015,361 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0737,640,639 - 37,750,121 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0741,114,606 - 41,223,138 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl741,114,697 - 41,220,579 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0741,153,926 - 41,262,537 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4736,493,661 - 36,600,280 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1736,513,931 - 36,620,551 (+)NCBI
Celera730,753,051 - 30,859,194 (+)NCBICelera
Cytogenetic Map7q13NCBI
Atp2b1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540526,872,379 - 26,932,703 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540526,872,379 - 26,932,270 (-)NCBIChiLan1.0ChiLan1.0
ATP2B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21097,607,011 - 97,674,855 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11297,603,409 - 97,725,055 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01287,107,900 - 87,229,514 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11290,427,560 - 90,495,320 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1290,427,560 - 90,495,320 (-)Ensemblpanpan1.1panPan2
ATP2B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11530,547,009 - 30,674,094 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1530,547,015 - 30,616,429 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1531,001,748 - 31,071,230 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01531,191,421 - 31,320,135 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1531,191,427 - 31,319,625 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11530,496,017 - 30,565,441 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01530,557,909 - 30,627,319 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01530,851,958 - 30,921,528 (-)NCBIUU_Cfam_GSD_1.0
Atp2b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494529,604,363 - 29,710,134 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365076,523,199 - 6,630,606 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365076,525,302 - 6,631,003 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP2B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl592,935,694 - 93,061,405 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1592,935,688 - 93,061,406 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2597,597,062 - 97,709,794 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ATP2B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11184,985,957 - 85,053,923 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1184,989,169 - 85,103,957 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037160,096,429 - 160,215,991 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atp2b1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475016,990,288 - 17,103,279 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Atp2b1
3763 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:649
Count of miRNA genes:439
Interacting mature miRNAs:494
Transcripts:ENSMUST00000020107
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302162Ednrbm1_mendothelin receptor type B modifier 1 (mouse)Not determined1092127383103713756Mouse
1301520Uvbi1_mUVB induced immunosuppression 1 (mouse)Not determined1086909085120909229Mouse
4142137Femwf3_mfemur work to failure 3 (mouse)Not determined75338568109338767Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
4142386Tgq20_mtriglyceride QTL 20 (mouse)Not determined88836456122836456Mouse
1357594Estoq3_membryo survival total QTL 3 (mouse)Not determined1084079650122041528Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
1357831Igf1sl2_mIGF-1 serum levels 2 (mouse)Not determined108769412799936278Mouse
4141479W10q8_mweight 10 weeks QTL 8 (mouse)Not determined84079650122041528Mouse
14747004Mancz8_mmandible centroid size 8 (mouse)1082078412116078412Mouse
4142496W6q8_mweight 6 weeks QTL 8 (mouse)Not determined84079650122041528Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
12910821Ogrq4_moverall growth rate QTL 4 (mouse)1092169056107319989Mouse
26884411Bzwq8_mbi-zygomatic width QTL 8, 10 week (mouse)1044876096115935905Mouse
11039497Ltpr5a_mLeishmania tropica response 5a (mouse)1073506901107507047Mouse
1357622Espq3_membryo survival preimplantation QTL 3 (mouse)Not determined1084079650122041528Mouse
4142365Egq9_mearly growth QTL 9 (mouse)Not determined84079650122041528Mouse
13208554Lgth11_mbody length 11 (mouse)1090835862120835905Mouse
1300533Aem3_manti-erythrocyte autoantibody modifier 3 (mouse)Not determined106549093899491121Mouse
1300921Skl4_mskeletal size (tail length) 4 (mouse)Not determined1088088254122088391Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045476096120635905Mouse
11251717Siim1_mstress induced immobility 1 (mouse)1078381268112381268Mouse
1300797Sluc22_msusceptibility to lung cancer 22 (mouse)Not determined1086713608120713756Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069735830130430862Mouse
11039516Ltpr5_mLeishmania tropica response 5 (mouse)1090506901125575232Mouse
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
13208560Wght9_mweight 9 (mouse)1059835822120835905Mouse
1301165Lith7_mlithogenic gene 7 (mouse)Not determined1082309418116309657Mouse
1302060El3_mepilepsy 3 (mouse)Not determined106549093899491121Mouse
1300908Insq4_minsulin QTL 4 (mouse)Not determined1086909085120909229Mouse
4141054mwfh_mmodifier of white forlock hypopigmentation (mouse)Not determined83017003117017136Mouse
4142461Bmd25_mbone mineral density 25 (mouse)Not determined1097217101130530862Mouse
26884447Sklq9_mskull length QTL 9, 10 week (mouse)1067335830111735905Mouse
11353832Pcholq4_mplasma cholesterol QTL 4 (mouse)1073987216125515907Mouse
4142074Tmevp2_mTheiler's murine encephalomyelitis virus persistence 2 (mouse)Not determined92729941111568319Mouse
1357779Tesq3_mtestis weight QTL 3 (mouse)Not determined1084079650122041528Mouse
11059553Lmr32d_mleishmaniasis resistance 32d (mouse)1082309418116309657Mouse
11059554Lmr32e_mleishmaniasis resistance 32e (mouse)1082309418116309657Mouse
11059555Lmr32f_mleishmaniasis resistance 32f (mouse)1082309418116309657Mouse
11533921Mvb2_mmodifier of vibrator 2 (mouse)1097217101130530862Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024675898121035905Mouse
26884424Zlq9_mzygomatic length QTL 9, 16 week (mouse)1063935779115935905Mouse
1357638Cia29_mcollagen induced arthritis 29 (mouse)Not determined1085454982118497353Mouse
26884430Zlq5_mzygomatic length QTL 5, 10 week (mouse)1067835830124835905Mouse
1357632Vtbt9_mvertebral trabecular bone trait 9 (mouse)Not determined1075338568109338767Mouse
12880413V125Dq9_mvitamin D active form serum level QTL 9 (mouse)1097535905130530862Mouse
11353843Gluq1_mblood glucose QTL 1 (mouse)1073987216125515907Mouse
4141402T2dm1sa_mtype 2 diabetes mellitus 1 in SMXA RI mice (mouse)Not determined97758644130530862Mouse
1301758Fcsa3_mfemoral cross-sectional area 3 (mouse)Not determined1089927651123927754Mouse
10043881Adip24_madiposity 24 (mouse)Not determined1082392803116392952Mouse
11533919Mvb4_mmodifier of vibrator 4 (mouse)397217101130530862Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021408154114217230Mouse
4141387Lgaq5_mlate growth adjusted QTL 5 (mouse)Not determined84079650122041528Mouse
11059550Lmr32a_mleishmaniasis resistance 32a (mouse)1082309418116309657Mouse
11059551Lmr32b_mleishmaniasis resistance 32b (mouse)1082309418116309657Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059335822122335905Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
1301737Insq9_minsulin QTL 9 (mouse)Not determined106549093899491121Mouse
1300975Fembrs3_mfemur breaking strength 3 (mouse)Not determined1075338568109338767Mouse
1357544Vtbt10_mvertebral trabecular bone trait 10 (mouse)Not determined1097217101130530862Mouse

Markers in Region
Atp2b1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10C3UniSTS
cM Map1050.97UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001359506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001359507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001359508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001359509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_026482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011243548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011243549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030245244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC153906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC160410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF162783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF357352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI892140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK013291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK027941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK031677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK042547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK053569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK078873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK133920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK136761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK137408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC024831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC025199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC029045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC030901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC049262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC057180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI732378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ176881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF750345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ128577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ321142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK393435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK624413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN691756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CV559947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U16707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000020107   ⟹   ENSMUSP00000020107
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1098,751,014 - 98,862,005 (+)Ensembl
GRCm38.p6 Ensembl1098,915,152 - 99,026,143 (+)Ensembl
Ensembl Acc Id: ENSMUST00000218312
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1098,850,755 - 98,852,971 (+)Ensembl
GRCm38.p6 Ensembl1099,014,893 - 99,017,109 (+)Ensembl
Ensembl Acc Id: ENSMUST00000218419
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1098,854,899 - 98,858,795 (+)Ensembl
GRCm38.p6 Ensembl1099,019,037 - 99,022,933 (+)Ensembl
Ensembl Acc Id: ENSMUST00000218695
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1098,821,993 - 98,824,326 (+)Ensembl
GRCm38.p6 Ensembl1098,986,131 - 98,988,464 (+)Ensembl
Ensembl Acc Id: ENSMUST00000218948   ⟹   ENSMUSP00000151441
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1098,850,831 - 98,859,685 (+)Ensembl
GRCm38.p6 Ensembl1099,014,969 - 99,023,823 (+)Ensembl
Ensembl Acc Id: ENSMUST00000219090   ⟹   ENSMUSP00000151934
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1098,837,304 - 98,847,332 (+)Ensembl
GRCm38.p6 Ensembl1099,001,442 - 99,011,470 (+)Ensembl
Ensembl Acc Id: ENSMUST00000219557   ⟹   ENSMUSP00000151791
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1098,750,268 - 98,822,984 (+)Ensembl
GRCm38.p6 Ensembl1098,914,406 - 98,987,122 (+)Ensembl
Ensembl Acc Id: ENSMUST00000219624   ⟹   ENSMUSP00000151598
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1098,751,334 - 98,832,792 (+)Ensembl
GRCm38.p6 Ensembl1098,915,472 - 98,996,930 (+)Ensembl
Ensembl Acc Id: ENSMUST00000220104   ⟹   ENSMUSP00000151572
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1098,850,908 - 98,859,431 (+)Ensembl
GRCm38.p6 Ensembl1099,015,046 - 99,023,569 (+)Ensembl
Ensembl Acc Id: ENSMUST00000220124   ⟹   ENSMUSP00000151970
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1098,850,805 - 98,859,317 (+)Ensembl
GRCm38.p6 Ensembl1099,014,943 - 99,023,455 (+)Ensembl
Ensembl Acc Id: ENSMUST00000220358
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1098,826,742 - 98,830,429 (+)Ensembl
GRCm38.p6 Ensembl1098,990,880 - 98,994,567 (+)Ensembl
RefSeq Acc Id: NM_001359506   ⟹   NP_001346435
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391098,750,504 - 98,862,005 (+)NCBI
GRCm381098,914,642 - 99,026,143 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001359507   ⟹   NP_001346436
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391098,751,014 - 98,862,005 (+)NCBI
GRCm381098,915,152 - 99,026,143 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001359508   ⟹   NP_001346437
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391098,750,504 - 98,862,005 (+)NCBI
GRCm381098,914,642 - 99,026,143 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001359509   ⟹   NP_001346438
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391098,750,504 - 98,862,005 (+)NCBI
GRCm381098,914,642 - 99,026,143 (+)NCBI
Sequence:
RefSeq Acc Id: NM_026482   ⟹   NP_080758
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391098,751,014 - 98,862,005 (+)NCBI
GRCm381098,915,152 - 99,026,143 (+)NCBI
MGSCv371098,377,786 - 98,488,777 (+)RGD
Celera10100,886,627 - 100,998,171 (+)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011243548   ⟹   XP_011241850
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391098,750,686 - 98,861,449 (+)NCBI
GRCm381098,915,025 - 99,025,587 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011243549   ⟹   XP_011241851
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391098,750,243 - 98,862,005 (+)NCBI
GRCm381098,914,630 - 99,025,587 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030245244   ⟹   XP_030101104
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391098,776,302 - 98,861,449 (+)NCBI
GRCm381098,940,440 - 99,025,587 (+)NCBI
Sequence:
RefSeq Acc Id: NP_080758   ⟸   NM_026482
- Peptide Label: isoform 2
- UniProtKB: G5E829 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011241851   ⟸   XM_011243549
- Peptide Label: isoform X2
- UniProtKB: G5E829 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011241850   ⟸   XM_011243548
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001346437   ⟸   NM_001359508
- Peptide Label: isoform 3
RefSeq Acc Id: NP_001346438   ⟸   NM_001359509
- Peptide Label: isoform 4
RefSeq Acc Id: NP_001346435   ⟸   NM_001359506
- Peptide Label: isoform 1
RefSeq Acc Id: NP_001346436   ⟸   NM_001359507
- Peptide Label: isoform 3
RefSeq Acc Id: XP_030101104   ⟸   XM_030245244
- Peptide Label: isoform X1
Ensembl Acc Id: ENSMUSP00000151441   ⟸   ENSMUST00000218948
Ensembl Acc Id: ENSMUSP00000020107   ⟸   ENSMUST00000020107
Ensembl Acc Id: ENSMUSP00000151934   ⟸   ENSMUST00000219090
Ensembl Acc Id: ENSMUSP00000151598   ⟸   ENSMUST00000219624
Ensembl Acc Id: ENSMUSP00000151791   ⟸   ENSMUST00000219557
Ensembl Acc Id: ENSMUSP00000151970   ⟸   ENSMUST00000220124
Ensembl Acc Id: ENSMUSP00000151572   ⟸   ENSMUST00000220104
Protein Domains
Cation-transporting P-type ATPase C-terminal   Cation-transporting P-type ATPase N-terminal   Plasma membrane calcium transporting P-type ATPase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G5E829-F1-model_v2 AlphaFold G5E829 1-1220 view protein structure

Promoters
RGD ID:6819021
Promoter ID:MM_KWN:5465
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000105284,   NM_026482
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361098,377,386 - 98,377,886 (+)MPROMDB
RGD ID:8673154
Promoter ID:EPDNEW_M14608
Type:initiation region
Name:Atp2b1_1
Description:Mus musculus ATPase, Ca++ transporting, plasma membrane 1 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M14609  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381098,915,152 - 98,915,212EPDNEW
RGD ID:8673156
Promoter ID:EPDNEW_M14609
Type:single initiation site
Name:Atp2b1_2
Description:Mus musculus ATPase, Ca++ transporting, plasma membrane 1 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M14608  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381098,945,683 - 98,945,743EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104653 AgrOrtholog
Ensembl Genes ENSMUSG00000019943 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000020107 ENTREZGENE
  ENSMUST00000020107.8 UniProtKB/Swiss-Prot
  ENSMUST00000218948.2 UniProtKB/TrEMBL
  ENSMUST00000219090.2 UniProtKB/TrEMBL
  ENSMUST00000219557.2 UniProtKB/TrEMBL
  ENSMUST00000219624.2 UniProtKB/TrEMBL
  ENSMUST00000220104.2 UniProtKB/TrEMBL
  ENSMUST00000220124.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.1110.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.1000 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Calcium-transporting ATPase, cytoplasmic transduction domain A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Calcium-transporting ATPase, transmembrane domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ATP_Ca_trans_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_P-typ_Ca-transp_plasma UniProtKB/Swiss-Prot
  ATPase_P-typ_cation-transptr_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_P-typ_cation-transptr_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_P-typ_cyto_dom_N UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  ATPase_P-typ_P_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_P-typ_TM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_P-typ_transduc_dom_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cation_transp_P_typ_ATPase UniProtKB/Swiss-Prot
  HAD-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HAD_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-type_ATPase_IIB UniProtKB/TrEMBL
  P_typ_ATPase UniProtKB/TrEMBL
  P_typ_ATPase_HD_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:67972 UniProtKB/Swiss-Prot
MGD MGI:104653 ENTREZGENE
NCBI Gene Atp2b1 ENTREZGENE
PANTHER CATION TRANSPORTING ATPASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24093:SF245 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ATP_Ca_trans_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cation_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cation_ATPase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cation_ATPase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  E1-E2_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Atp2b1 PhenoGen
PRINTS CATATPASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ATPASE_E1_E2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Cation_ATPase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56784 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81653 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81660 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81665 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1W2P6X7_MOUSE UniProtKB/TrEMBL
  A0A1W2P772_MOUSE UniProtKB/TrEMBL
  A0A1W2P7C7_MOUSE UniProtKB/TrEMBL
  A0A1W2P7R3_MOUSE UniProtKB/TrEMBL
  A0A1W2P867_MOUSE UniProtKB/TrEMBL
  A0A1W2P882_MOUSE UniProtKB/TrEMBL
  AT2B1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q05CJ5_MOUSE UniProtKB/TrEMBL
  Q3TC38_MOUSE UniProtKB/TrEMBL
  Q3TDJ2_MOUSE UniProtKB/TrEMBL
  Q3TSK3_MOUSE UniProtKB/TrEMBL
  Q6PG79_MOUSE UniProtKB/TrEMBL
  Q8K314_MOUSE UniProtKB/TrEMBL