Il1r1 (interleukin 1 receptor, type I) - Rat Genome Database

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Gene: Il1r1 (interleukin 1 receptor, type I) Mus musculus
Analyze
Symbol: Il1r1
Name: interleukin 1 receptor, type I
RGD ID: 735431
MGI Page MGI
Description: Enables interleukin-1 binding activity; interleukin-1 receptor activity; and protease binding activity. Involved in interleukin-1-mediated signaling pathway. Acts upstream of or within several processes, including cytokine-mediated signaling pathway; positive regulation of interleukin-1-mediated signaling pathway; and positive regulation of neutrophil extravasation. Located in external side of plasma membrane. Is expressed in aorta-gonad-mesonephros; brain; liver; spleen; and uterus. Used to study Sjogren's syndrome and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in chronic recurrent multifocal osteomyelitis; systemic scleroderma; and type 1 diabetes mellitus. Orthologous to human IL1R1 (interleukin 1 receptor type 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CD121; CD121 antigen-like family member A; CD121a; CD121b; I; IL-; IL-1 receptor alpha chain; IL-1R-1; IL-1R-alpha; IL-1R1; IL-1RT-1; IL-1RT1; IL-iR; Il1; Il1r-1; interleukin-1 receptor alpha; interleukin-1 receptor type 1; interleukin-1 receptor type I; MGC129154; p80
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39140,261,651 - 40,355,361 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl140,264,240 - 40,356,417 (+)EnsemblGRCm39 Ensembl
GRCm38140,222,480 - 40,316,201 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl140,225,080 - 40,317,257 (+)EnsemblGRCm38mm10GRCm38
MGSCv37140,281,925 - 40,373,022 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36140,169,626 - 40,260,723 (+)NCBIMGSCv36mm8
Celera140,033,653 - 40,127,353 (+)NCBICelera
Cytogenetic Map1BNCBI
cM Map118.81NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (EXP)
(S)-nicotine  (ISO)
1,10-phenanthroline  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-hydroxycyclophosphamide  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
adenosine  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
AH23848  (ISO)
albendazole  (ISO)
aldrin  (EXP)
all-trans-retinoic acid  (ISO)
aluminium hydroxide  (EXP)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
asperentin  (EXP)
atrazine  (ISO)
Bardoxolone methyl  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bortezomib  (ISO)
Brevianamide A  (EXP)
butanal  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
captan  (EXP)
carbamazepine  (ISO)
carbon nanotube  (EXP,ISO)
carmustine  (ISO)
chenodeoxycholic acid  (ISO)
CHIR 99021  (ISO)
chloroethene  (EXP)
chlorpyrifos  (EXP)
chromium(6+)  (ISO)
chrysin  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (EXP)
cisplatin  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP,ISO)
cortisol  (ISO)
coumestrol  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
DDT  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (EXP)
dexamethasone  (ISO)
dextran sulfate  (EXP)
dibenzofurans  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (EXP)
diclofenac  (EXP,ISO)
diethyl maleate  (ISO)
dimethyl sulfoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
edaravone  (ISO)
ellagic acid  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
erlotinib hydrochloride  (ISO)
fenvalerate  (ISO)
flavonoids  (ISO)
folic acid  (EXP)
folpet  (EXP)
fonofos  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (ISO)
gallic acid  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
hydrogen peroxide  (ISO)
indirubin  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
lenalidomide  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (EXP,ISO)
magnesium dihydroxide  (EXP)
manganese(II) chloride  (ISO)
methimazole  (ISO)
methoxychlor  (ISO)
methyllycaconitine  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Muraglitazar  (ISO)
mycophenolic acid  (EXP)
mycotoxin  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
naringin  (ISO)
neoechinulin A  (EXP)
nevirapine  (EXP)
nickel sulfate  (ISO)
nicotine  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
o-anisidine  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenformin  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phytoestrogen  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
prostaglandin E2  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
Soman  (EXP)
sterigmatocystin  (EXP)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sulindac sulfide  (ISO)
Sunset Yellow FCF  (ISO)
tamoxifen  (EXP)
tartrazine  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
Tesaglitazar  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
TMC-120A  (EXP)
toluene  (ISO)
triadimefon  (ISO)
tributylstannane  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimethyltin  (EXP)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vanadyl sulfate  (EXP)
vinclozolin  (ISO)
vincristine  (ISO)
XAV939  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal blood vessel physiology  (IAGP)
abnormal brain wave pattern  (IAGP)
abnormal cell death  (IAGP)
abnormal chemokine level  (IAGP)
abnormal circadian temperature homeostasis  (IAGP)
abnormal conjunctiva goblet cell morphology  (IAGP)
abnormal cornea epithelium morphology  (IAGP)
abnormal heart morphology  (IEA)
abnormal inflammatory response  (IAGP)
abnormal kidney morphology  (IEA)
abnormal lacrimal gland morphology  (IAGP)
abnormal lean body mass  (IAGP)
abnormal leukocyte cell number  (IAGP)
abnormal leukopoiesis  (IAGP)
abnormal microglial cell activation  (IAGP)
abnormal nervous system electrophysiology  (IAGP)
abnormal neutrophil physiology  (IAGP)
abnormal ocular surface morphology  (IAGP)
abnormal response/metabolism to endogenous compounds  (IAGP)
abnormal skin morphology  (IAGP)
abnormal sleep pattern  (IAGP)
abnormal spleen morphology  (IEA)
abnormal vascular wound healing  (IAGP)
cornea opacity  (IAGP)
decreased anxiety-related response  (IAGP)
decreased blood urea nitrogen level  (IAGP)
decreased circulating creatinine level  (IAGP)
decreased circulating interleukin-18 level  (IAGP)
decreased circulating interleukin-6 level  (IAGP)
decreased circulating serum amyloid protein level  (IAGP)
decreased eosinophil cell number  (IAGP)
decreased immunoglobulin level  (IAGP)
decreased incidence of tumors by chemical induction  (IAGP)
decreased interleukin-6 secretion  (IAGP)
decreased locomotor activity  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased monocyte cell number  (IAGP)
decreased neutrophil cell number  (IAGP)
decreased response to leptin  (IAGP)
decreased susceptibility to atherosclerosis  (IAGP)
decreased susceptibility to autoimmune diabetes  (IAGP)
decreased susceptibility to endotoxin shock  (IAGP)
decreased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
decreased susceptibility to experimental autoimmune uveoretinitis  (IAGP)
decreased susceptibility to induced arthritis  (IAGP)
decreased susceptibility to kidney reperfusion injury  (IAGP)
decreased susceptibility to type IV hypersensitivity reaction  (IAGP)
decreased systemic arterial blood pressure  (IAGP)
decreased T cell number  (IAGP)
decreased T cell proliferation  (IAGP)
decreased T helper 1 cell number  (IAGP)
decreased T-helper 17 cell number  (IAGP)
decreased transforming growth factor beta level  (IAGP)
decreased tumor necrosis factor secretion  (IAGP)
delayed tooth eruption  (IAGP)
dental pulp necrosis  (IAGP)
dry eyes  (IAGP)
enhanced contextual conditioning behavior  (IAGP)
enhanced wound healing  (IAGP)
enlarged heart  (IEA)
enlarged kidney  (IEA)
enlarged spleen  (IEA)
impaired febrile response  (IAGP)
impaired glucose tolerance  (IAGP)
impaired neutrophil chemotaxis  (IAGP)
impaired neutrophil recruitment  (IAGP)
increased abdominal fat pad weight  (IAGP)
increased body length  (IAGP)
increased body mass index  (IAGP)
increased body weight  (IAGP)
increased bone resorption  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating insulin-like growth factor I level  (IAGP)
increased circulating interleukin-1 beta level  (IAGP)
increased circulating interleukin-18 level  (IAGP)
increased circulating interleukin-6 level  (IAGP)
increased circulating leptin level  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased gonadal fat pad weight  (IAGP)
increased growth rate  (IAGP)
increased inguinal fat pad weight  (IAGP)
increased interleukin-1 beta secretion  (IAGP)
increased kidney weight  (IEA)
increased liver weight  (IAGP)
increased mesenteric fat pad weight  (IAGP)
increased percent body fat/body weight  (IAGP)
increased respiratory quotient  (IAGP)
increased retroperitoneal fat pad weight  (IAGP)
increased susceptibility to age related obesity  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to bacterial infection induced morbidity/mortality  (IAGP)
increased susceptibility to induced arthritis  (IAGP)
increased susceptibility to induced colitis  (IAGP)
increased susceptibility to Riboviria infection  (IAGP)
increased susceptibility to xenobiotic induced morbidity/mortality  (IAGP)
increased total body fat amount  (IAGP)
increased vasoconstriction  (IAGP)
increased vasodilation  (IAGP)
insulin resistance  (IAGP)
interstitial pneumonia  (IAGP)
keratoconjunctivitis  (IAGP)
lacrimal gland inflammation  (IAGP)
lung inflammation  (IAGP)
no abnormal phenotype detected  (IAGP)
osteomyelitis  (IAGP)
sepsis  (IAGP)
skin inflammation  (IAGP)
thrombocytopenia  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Characterization of new polymorphisms in the 5' UTR of the human interleukin-1 receptor type 1 (IL1R1) gene: linkage to type 1 diabetes and correlation to IL-1RI plasma level. Bergholdt R, etal., Genes Immun. 2000 Dec;1(8):495-500.
2. Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19. Blanco-Melo D, etal., Cell. 2020 May 28;181(5):1036-1045.e9. doi: 10.1016/j.cell.2020.04.026. Epub 2020 May 15.
3. Sensory pulpal nerve fibres and trigeminal ganglion neurons express IL-1RI: a potential mechanism for development of inflammatory hyperalgesia. Bletsa A, etal., Int Endod J. 2009 Nov;42(11):978-86. doi: 10.1111/j.1365-2591.2009.01605.x. Epub 2009 Sep 1.
4. Interleukin 1 (IL-1) and IL-1-receptor antagonist (IL-1-RA) in middle ear cholesteatoma: an analysis of protein production and biological activity. Bujia J, etal., Eur Arch Otorhinolaryngol. 1996;253(4-5):252-5.
5. Astrocyte reactivity to unconjugated bilirubin requires TNF-alpha and IL-1beta receptor signaling pathways. Fernandes A, etal., Glia. 2011 Jan;59(1):14-25. doi: 10.1002/glia.21072. Epub 2010 Oct 21.
6. Protection from experimental ventilator-induced acute lung injury by IL-1 receptor blockade. Frank JA, etal., Thorax. 2008 Feb;63(2):147-53. Epub 2007 Sep 27.
7. Gamma interferon and interleukin-1 receptor 1 regulate neutrophil recruitment to the corneal stroma in a murine model of Onchocerca volvulus keratitis. Gentil K and Pearlman E, Infect Immun. 2009 Apr;77(4):1606-12. doi: 10.1128/IAI.00671-08. Epub 2009 Jan 21.
8. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Huang C, etal., Lancet. 2020 Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5. Epub 2020 Jan 24.
9. Localization and characterization of interleukin-1 receptors in the islets of Langerhans from control and nonobese diabetic mice. Jafarian-Tehrani M, etal., Endocrinology. 1995 Feb;136(2):609-13.
10. Increased interleukin 1 receptor, type I, at messenger RNA and protein level in skin fibroblasts from patients with systemic sclerosis. Kawaguchi Y, etal., Biochem Biophys Res Commun. 1992 May 15;184(3):1504-10.
11. Elucidating the molecular physiopathology of acute respiratory distress syndrome in severe acute respiratory syndrome patients. Kong SL, etal., Virus Res. 2009 Nov;145(2):260-9. Epub 2009 Jul 25.
12. An association between type 1 diabetes and the interleukin-1 receptor type 1 gene. The DiMe Study Group. Childhood Diabetes in Finland. Metcalfe KA, etal., Hum Immunol. 1996 Nov;51(1):41-8.
13. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
14. MGDs mouse GO annotations MGD data from the GO Consortium
15. MGD IEA MGD IEA
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
18. Mouse MP Annotation Import Pipeline RGD automated import pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Comprehensive gene review and curation RGD comprehensive gene curation
22. A disintegrin and metalloprotease with thrombospondin type1 motifs (ADAMTS-1) and IL-1 receptor type 1 mRNAs are simultaneously induced in nerve injured motor neurons. Sasaki M, etal., Brain Res Mol Brain Res. 2001 Apr 18;89(1-2):158-63.
23. Combined epineurial therapy with neutralizing antibodies to tumor necrosis factor-alpha and interleukin-1 receptor has an additive effect in reducing neuropathic pain in mice. Schafers M, etal., Neurosci Lett. 2001 Sep 14;310(2-3):113-6.
24. DNA microarray analysis of the effect on inflammation in patients treated with acupuncture for allergic rhinitis. Shiue HS, etal., J Altern Complement Med. 2008 Jul;14(6):689-98.
25. The IL-1 family: regulators of immunity. Sims JE and Smith DE, Nat Rev Immunol. 2010 Feb;10(2):89-102. Epub 2010 Jan 18.
26. Additive anti-hyperalgesia of electroacupuncture and intrathecal antisense oligodeoxynucleotide to interleukin-1 receptor type I on carrageenan-induced inflammatory pain in rats. Song MJ, etal., Brain Res Bull. 2009 Mar 30;78(6):335-41. doi: 10.1016/j.brainresbull.2008.10.009. Epub 2008 Nov 18.
27. Upregulation of type I interleukin-1 receptor after traumatic spinal cord injury in adult rats. Wang XF, etal., Acta Neuropathol. 2006 Mar;111(3):220-8. Epub 2006 Feb 3.
28. Interleukin-1 contributes to an effective clearance of Mycobacterium kansasii from the respiratory tract. Wieland CW, etal., Microbes Infect. 2006 Aug;8(9-10):2409-13. Epub 2006 Jun 2.
29. Enhanced susceptibility to immune nephritis in DBA/1 mice is contingent upon IL-1 expression. Xie C, etal., Clin Immunol. 2007 Jul;124(1):49-56. Epub 2007 May 17.
30. Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19. Yang Y, etal., J Allergy Clin Immunol. 2020 Apr 29. pii: S0091-6749(20)30576-5. doi: 10.1016/j.jaci.2020.04.027.
31. Innate immune regulation of Serratia marcescens-induced corneal inflammation and infection. Zhou R, etal., Invest Ophthalmol Vis Sci. 2012 Oct 25;53(11):7382-8. doi: 10.1167/iovs.12-10238.
Additional References at PubMed
PMID:1386414   PMID:1387109   PMID:1387148   PMID:1532025   PMID:1533388   PMID:1672292   PMID:1828071   PMID:1828344   PMID:1832015   PMID:1833184   PMID:2530579   PMID:2530587  
PMID:2788176   PMID:2969618   PMID:7499265   PMID:7578987   PMID:7615010   PMID:7683560   PMID:7775431   PMID:7848516   PMID:7877456   PMID:7894170   PMID:7916701   PMID:7927486  
PMID:7953641   PMID:7959748   PMID:8007943   PMID:8018912   PMID:8020198   PMID:8031998   PMID:8034307   PMID:8127400   PMID:8276397   PMID:8376789   PMID:8432531   PMID:8530075  
PMID:8581744   PMID:8661203   PMID:8662235   PMID:8706893   PMID:8751373   PMID:8751591   PMID:8755642   PMID:8770556   PMID:8824815   PMID:8875997   PMID:8884266   PMID:8953518  
PMID:9126479   PMID:9166705   PMID:9278338   PMID:9292778   PMID:9317135   PMID:9399942   PMID:9426216   PMID:9449661   PMID:9551933   PMID:9555664   PMID:9606417   PMID:9607815  
PMID:9651547   PMID:9692874   PMID:10198176   PMID:10201952   PMID:10349636   PMID:10435584   PMID:10509653   PMID:10595943   PMID:10607711   PMID:10721695   PMID:10749768   PMID:10763993  
PMID:10854325   PMID:10946764   PMID:11015350   PMID:11035056   PMID:11042159   PMID:11076861   PMID:11122355   PMID:11133507   PMID:11217851   PMID:11238652   PMID:11493610   PMID:11673538  
PMID:11673547   PMID:11756486   PMID:11786971   PMID:11791667   PMID:11792633   PMID:11796828   PMID:11880380   PMID:11890668   PMID:11994477   PMID:12010781   PMID:12077269   PMID:12093872  
PMID:12097396   PMID:12122068   PMID:12133972   PMID:12135759   PMID:12223557   PMID:12414526   PMID:12466851   PMID:12477932   PMID:12504878   PMID:12566416   PMID:12614028   PMID:12672065  
PMID:12697697   PMID:12707352   PMID:12759568   PMID:12773775   PMID:12927619   PMID:12960098   PMID:12975454   PMID:14620878   PMID:14622131   PMID:14635056   PMID:14693705   PMID:14966082  
PMID:14978111   PMID:15044707   PMID:15100310   PMID:15161633   PMID:15240711   PMID:15277240   PMID:15292196   PMID:15353494   PMID:15509550   PMID:15664785   PMID:15668736   PMID:15678109  
PMID:15722603   PMID:15797311   PMID:15858027   PMID:15893609   PMID:15896328   PMID:15939811   PMID:15972657   PMID:16029197   PMID:16081822   PMID:16126903   PMID:16141072   PMID:16141073  
PMID:16179572   PMID:16272281   PMID:16272344   PMID:16294221   PMID:16301661   PMID:16358337   PMID:16365459   PMID:16407889   PMID:16413925   PMID:16415102   PMID:16426759   PMID:16444258  
PMID:16477040   PMID:16565512   PMID:16569679   PMID:16574667   PMID:16602821   PMID:16644674   PMID:16645594   PMID:16670325   PMID:16688680   PMID:16818675   PMID:16886064   PMID:16941354  
PMID:16954498   PMID:16983331   PMID:17122101   PMID:17182684   PMID:17192486   PMID:17229673   PMID:17283089   PMID:17322383   PMID:17339472   PMID:17404295   PMID:17507369   PMID:17512577  
PMID:17549256   PMID:17572686   PMID:17575079   PMID:17590392   PMID:17617611   PMID:17631139   PMID:17700577   PMID:17728444   PMID:17869478   PMID:17881516   PMID:17898219   PMID:17908936  
PMID:17942936   PMID:17976923   PMID:17982084   PMID:17992263   PMID:18037570   PMID:18096436   PMID:18178625   PMID:18178857   PMID:18191113   PMID:18211965   PMID:18250441   PMID:18256152  
PMID:18268142   PMID:18287559   PMID:18295350   PMID:18322211   PMID:18329246   PMID:18434191   PMID:18477692   PMID:18480244   PMID:18490717   PMID:18495787   PMID:18515164   PMID:18535174  
PMID:18559949   PMID:18562486   PMID:18566426   PMID:18617619   PMID:18787019   PMID:18805969   PMID:18931327   PMID:18941239   PMID:18950689   PMID:18996842   PMID:19006696   PMID:19074813  
PMID:19075023   PMID:19079579   PMID:19100239   PMID:19158675   PMID:19196714   PMID:19218193   PMID:19229053   PMID:19247983   PMID:19289507   PMID:19295146   PMID:19342509   PMID:19342666  
PMID:19347044   PMID:19362022   PMID:19389930   PMID:19406986   PMID:19414781   PMID:19414802   PMID:19429130   PMID:19501000   PMID:19501001   PMID:19535637   PMID:19541630   PMID:19576795  
PMID:19587162   PMID:19633315   PMID:19652710   PMID:19657352   PMID:19724062   PMID:19762681   PMID:19833765   PMID:19853894   PMID:19875664   PMID:19932745   PMID:19940113   PMID:19950169  
PMID:19959756   PMID:20007584   PMID:20042577   PMID:20166142   PMID:20181656   PMID:20200276   PMID:20220089   PMID:20364087   PMID:20393140   PMID:20430449   PMID:20488784   PMID:20545758  
PMID:20558823   PMID:20585036   PMID:20605606   PMID:20617171   PMID:20696775   PMID:20815704   PMID:20817874   PMID:20854134   PMID:20854891   PMID:20920344   PMID:20926563   PMID:20956347  
PMID:20971730   PMID:20974829   PMID:20980463   PMID:21041641   PMID:21048113   PMID:21057511   PMID:21059855   PMID:21091783   PMID:21093318   PMID:21115691   PMID:21169541   PMID:21170027  
PMID:21170303   PMID:21191403   PMID:21206087   PMID:21270399   PMID:21282379   PMID:21300825   PMID:21349431   PMID:21421554   PMID:21421852   PMID:21464320   PMID:21474346   PMID:21482737  
PMID:21490151   PMID:21497116   PMID:21515659   PMID:21515850   PMID:21525884   PMID:21540455   PMID:21551232   PMID:21565393   PMID:21576463   PMID:21600797   PMID:21670171   PMID:21741932  
PMID:21828249   PMID:21835155   PMID:21844393   PMID:21856425   PMID:21858022   PMID:21873635   PMID:21880915   PMID:21975862   PMID:21983279   PMID:22000287   PMID:22000485   PMID:22025515  
PMID:22025550   PMID:22058415   PMID:22123924   PMID:22137454   PMID:22140485   PMID:22158745   PMID:22163019   PMID:22201681   PMID:22206014   PMID:22213805   PMID:22231738   PMID:22236482  
PMID:22238457   PMID:22241982   PMID:22245214   PMID:22251454   PMID:22297845   PMID:22307620   PMID:22331066   PMID:22345651   PMID:22345669   PMID:22387068   PMID:22403439   PMID:22414156  
PMID:22466646   PMID:22516259   PMID:22541070   PMID:22547706   PMID:22565313   PMID:22586037   PMID:22592923   PMID:22636321   PMID:22674984   PMID:22706077   PMID:22723524   PMID:22745710  
PMID:22778412   PMID:22780103   PMID:22802353   PMID:22825446   PMID:22829762   PMID:22841542   PMID:22854286   PMID:22856653   PMID:22904305   PMID:22908325   PMID:22911706   PMID:22914048  
PMID:22945633   PMID:22949675   PMID:22980983   PMID:22985464   PMID:23034169   PMID:23034280   PMID:23035103   PMID:23064362   PMID:23090995   PMID:23115038   PMID:23142783   PMID:23148704  
PMID:23209417   PMID:23219391   PMID:23255360   PMID:23297192   PMID:23314004   PMID:23341960   PMID:23371061   PMID:23395675   PMID:23407395   PMID:23440414   PMID:23460727   PMID:23460746  
PMID:23475218   PMID:23487424   PMID:23492189   PMID:23555256   PMID:23592480   PMID:23658628   PMID:23664095   PMID:23675299   PMID:23696660   PMID:23708119   PMID:23708969   PMID:23750260  
PMID:23845567   PMID:23850243   PMID:23921145   PMID:23935505   PMID:23995233   PMID:24012762   PMID:24013028   PMID:24042114   PMID:24048027   PMID:24055061   PMID:24067878   PMID:24078695  
PMID:24082072   PMID:24084736   PMID:24089191   PMID:24093676   PMID:24098823   PMID:24143217   PMID:24157462   PMID:24205219   PMID:24395802   PMID:24439266   PMID:24458363   PMID:24458711  
PMID:24477914   PMID:24523548   PMID:24525743   PMID:24614655   PMID:24625929   PMID:24651866   PMID:24663677   PMID:24681250   PMID:24706750   PMID:24732356   PMID:24745336   PMID:24805106  
PMID:24807222   PMID:24849347   PMID:24909159   PMID:24927559   PMID:24943488   PMID:24947356   PMID:24952961   PMID:24973819   PMID:24988285   PMID:25015831   PMID:25024136   PMID:25043000  
PMID:25046000   PMID:25050810   PMID:25114230   PMID:25166912   PMID:25197170   PMID:25198773   PMID:25200056   PMID:25220465   PMID:25225402   PMID:25240383   PMID:25244011   PMID:25263489  
PMID:25295542   PMID:25326801   PMID:25362351   PMID:25474208   PMID:25500839   PMID:25551609   PMID:25583527   PMID:25607238   PMID:25607885   PMID:25621893   PMID:25628461   PMID:25629406  
PMID:25642823   PMID:25693118   PMID:25698726   PMID:25725107   PMID:25839897   PMID:25849975   PMID:25875529   PMID:25880604   PMID:25959047   PMID:25964372   PMID:26006013   PMID:26008898  
PMID:26011644   PMID:26034210   PMID:26034289   PMID:26038565   PMID:26067604   PMID:26080440   PMID:26096304   PMID:26147228   PMID:26163371   PMID:26170030   PMID:26187411   PMID:26203636  
PMID:26231118   PMID:26269257   PMID:26272906   PMID:26279140   PMID:26305968   PMID:26341401   PMID:26358260   PMID:26367131   PMID:26367276   PMID:26384545   PMID:26440518   PMID:26536497  
PMID:26572063   PMID:26603191   PMID:26643477   PMID:26682985   PMID:26682986   PMID:26690700   PMID:26692072   PMID:26712462   PMID:26787865   PMID:26856697   PMID:26885858   PMID:26902320  
PMID:26912904   PMID:26930558   PMID:26953152   PMID:26972847   PMID:26978520   PMID:27001940   PMID:27007676   PMID:27071119   PMID:27111842   PMID:27133574   PMID:27139491   PMID:27189410  
PMID:27193261   PMID:27226621   PMID:27230858   PMID:27273552   PMID:27297888   PMID:27318131   PMID:27328989   PMID:27350651   PMID:27365531   PMID:27374884   PMID:27411587   PMID:27418552  
PMID:27526865   PMID:27542117   PMID:27551155   PMID:27551932   PMID:27569535   PMID:27595596   PMID:27632536   PMID:27716507   PMID:27820702   PMID:27824289   PMID:27827809   PMID:27846608  
PMID:27875989   PMID:27882934   PMID:27892465   PMID:27903802   PMID:27926940   PMID:27939674   PMID:27982014   PMID:28002730   PMID:28017833   PMID:28057979   PMID:28092375   PMID:28111081  
PMID:28223334   PMID:28247861   PMID:28273457   PMID:28347403   PMID:28355185   PMID:28355571   PMID:28375155   PMID:28397782   PMID:28410990   PMID:28450382   PMID:28468973   PMID:28504245  
PMID:28537251   PMID:28585438   PMID:28655587   PMID:28687790   PMID:28747793   PMID:28778995   PMID:28784844   PMID:28790324   PMID:28796783   PMID:28808159   PMID:28813659   PMID:28875549  
PMID:28895072   PMID:28895840   PMID:28978634   PMID:28982129   PMID:29036304   PMID:29045388   PMID:29062042   PMID:29072292   PMID:29101209   PMID:29120744   PMID:29123474   PMID:29146733  
PMID:29150241   PMID:29196621   PMID:29199946   PMID:29217508   PMID:29249358   PMID:29282220   PMID:29335509   PMID:29366788   PMID:29366909   PMID:29515025   PMID:29551594   PMID:29576451  
PMID:29576482   PMID:29601781   PMID:29652914   PMID:29735654   PMID:29768967   PMID:29790392   PMID:29805094   PMID:29886157   PMID:29914854   PMID:30025110   PMID:30033154   PMID:30068597  
PMID:30146391   PMID:30170814   PMID:30185516   PMID:30214011   PMID:30282719   PMID:30287499   PMID:30366930   PMID:30392829   PMID:30404813   PMID:30455400   PMID:30523277   PMID:30552020  
PMID:30635238   PMID:30650348   PMID:30650375   PMID:30662948   PMID:30675064   PMID:30683620   PMID:30755603   PMID:30811982   PMID:30833749   PMID:30858427   PMID:30910860   PMID:30914642  
PMID:30926232   PMID:30937919   PMID:30979817   PMID:31029578   PMID:31063608   PMID:31076358   PMID:31079916   PMID:31141402   PMID:31143178   PMID:31167146   PMID:31220272   PMID:31228609  
PMID:31230859   PMID:31332247   PMID:31393855   PMID:31471109   PMID:31499011   PMID:31507610   PMID:31524632   PMID:31533918   PMID:31738006   PMID:31819009   PMID:31836429   PMID:31915130  
PMID:31935195   PMID:31975434   PMID:31992567   PMID:32070376   PMID:32181339   PMID:32268786   PMID:32269339   PMID:32295905   PMID:32350081   PMID:32402278   PMID:32421904   PMID:32433977  
PMID:32444870   PMID:32561755   PMID:32573694   PMID:32703941   PMID:32719155   PMID:32733464   PMID:32750316   PMID:32758418   PMID:32817286   PMID:32841604   PMID:32973293   PMID:32973802  
PMID:33020661   PMID:33030508   PMID:33051350   PMID:33116136   PMID:33123170   PMID:33184178   PMID:33240286   PMID:33414187   PMID:33619117   PMID:33621212   PMID:33798492   PMID:33894128  
PMID:33932339   PMID:33941650   PMID:33952660   PMID:33953267   PMID:33958388   PMID:33963061   PMID:34038731   PMID:34233954   PMID:34249474   PMID:34322116   PMID:34433045   PMID:34475534  
PMID:34525198   PMID:34603325   PMID:34625556   PMID:34847078   PMID:34894725   PMID:34999736   PMID:35032573   PMID:35074921   PMID:35091314   PMID:35108537   PMID:35120600   PMID:35235356  
PMID:35244027   PMID:35288304   PMID:35332327   PMID:35483374   PMID:35670567   PMID:35777130   PMID:35908547   PMID:35962064   PMID:36112693   PMID:36184639   PMID:36288707   PMID:36443301  
PMID:36476935   PMID:36640762   PMID:36645406   PMID:36652908   PMID:36758176   PMID:36766797   PMID:36834943   PMID:37040404   PMID:37065770   PMID:37265402   PMID:37315560   PMID:37330908  
PMID:37392737   PMID:37483624   PMID:37505422   PMID:37539090   PMID:37809058   PMID:37884959   PMID:38053332   PMID:38203319   PMID:38428422   PMID:38493579   PMID:38594380   PMID:38640835  
PMID:38718049   PMID:39030280  


Genomics

Comparative Map Data
Il1r1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39140,261,651 - 40,355,361 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl140,264,240 - 40,356,417 (+)EnsemblGRCm39 Ensembl
GRCm38140,222,480 - 40,316,201 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl140,225,080 - 40,317,257 (+)EnsemblGRCm38mm10GRCm38
MGSCv37140,281,925 - 40,373,022 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36140,169,626 - 40,260,723 (+)NCBIMGSCv36mm8
Celera140,033,653 - 40,127,353 (+)NCBICelera
Cytogenetic Map1BNCBI
cM Map118.81NCBI
IL1R1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382102,070,390 - 102,179,874 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2102,064,544 - 102,179,874 (+)EnsemblGRCh38hg38GRCh38
GRCh372102,686,850 - 102,796,334 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362102,136,834 - 102,162,766 (+)NCBINCBI36Build 36hg18NCBI36
Build 342102,228,919 - 102,254,852NCBI
Celera296,971,617 - 96,997,550 (+)NCBICelera
Cytogenetic Map2q11.2-q12.1NCBI
HuRef296,534,264 - 96,560,197 (+)NCBIHuRef
CHM1_12102,774,745 - 102,800,675 (+)NCBICHM1_1
T2T-CHM13v2.02102,528,685 - 102,638,160 (+)NCBIT2T-CHM13v2.0
Il1r1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8950,000,558 - 50,076,579 (+)NCBIGRCr8
mRatBN7.2942,504,917 - 42,580,958 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl942,504,735 - 42,579,937 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx951,042,291 - 51,080,451 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0956,165,013 - 56,203,144 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0954,441,033 - 54,478,767 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0946,962,291 - 47,038,139 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl946,962,288 - 47,036,670 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0946,647,422 - 46,723,241 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4939,434,910 - 39,473,552 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1939,434,750 - 39,475,060 (+)NCBI
Celera940,285,956 - 40,323,730 (+)NCBICelera
RH 3.4 Map9396.1RGD
Cytogenetic Map9q22NCBI
Il1r1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554707,685,498 - 7,703,374 (+)NCBIChiLan1.0ChiLan1.0
IL1R1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21226,052,033 - 26,167,680 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A26,054,794 - 26,164,430 (-)NCBINHGRI_mPanPan1
PanPan1.12A103,151,559 - 103,230,005 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A103,193,131 - 103,230,005 (+)Ensemblpanpan1.1panPan2
IL1R1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11040,825,986 - 40,897,898 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1040,827,377 - 40,897,596 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1040,751,798 - 40,823,679 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01041,692,476 - 41,764,370 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1041,692,623 - 41,811,603 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11041,406,689 - 41,478,437 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01041,688,685 - 41,760,634 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01041,880,427 - 41,952,281 (-)NCBIUU_Cfam_GSD_1.0
Il1r1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629290,252,781 - 90,324,177 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936713808,659 - 881,076 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936713808,761 - 881,070 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL1R1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl352,192,915 - 52,288,485 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1352,192,912 - 52,334,734 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2354,729,121 - 54,757,667 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL1R1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1145,781,486 - 5,852,872 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl145,781,479 - 5,855,942 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041173,465,069 - 173,539,878 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il1r1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247496,708,522 - 6,739,871 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247496,661,142 - 6,737,988 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Il1r1
3472 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1885
Count of miRNA genes:537
Interacting mature miRNAs:647
Transcripts:ENSMUST00000027241, ENSMUST00000114795
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1301011Cplaq4_mcircadian period of locomotor activity 4 (mouse)Not determined1967344243673601Mouse
1357524W6q14_mweight 6 weeks QTL 14 (mouse)Not determined13476013873976915Mouse
1301073Orch5_mautoimmune orchitis resistance 5 (mouse)Not determined11906535153065454Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
1357651Lgq5_mlate growth QTL 5 (mouse)Not determined13476013873976915Mouse
11100001Col4a1m1_mcollagen, type IV, alpha 1 modifier 1 (mouse)12555019162946882Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
1301240Sluc15_msusceptibility to lung cancer 15 (mouse)Not determined11906535153065454Mouse
1357759W3q12_mweight 3 weeks QTL 12 (mouse)Not determined13476013873976915Mouse
14700685Civq2_mcerebral infarct volume QTL 2 (mouse)11134048245340482Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139132808126445310Mouse
1301756Pgia1_mproteoglycan induced arthritis 1 (mouse)Not determined11906535153065454Mouse
1301954Lrnx11_mlearning-contextual 11 (mouse)Not determined13913280874516365Mouse
14700785Syncq2_msynovial calcification QTL 2 (mouse)13969616040499160Mouse
12880407V125Dq2_mvitamin D active form serum level QTL 2 (mouse)11933908153339081Mouse
1357824Estoq4_membryo survival total QTL 4 (mouse)Not determined13476013873976915Mouse
1357506W10q6_mweight 10 weeks QTL 6 (mouse)Not determined13476013873976915Mouse
1357475w3q13_mweight 3 weeks QTL 13 (mouse)Not determined12310959173976915Mouse
39128207Lwq16_mliver weight QTL 16 (mouse)13476013873976915Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
12880409V125Dq1_mvitamin D active form serum level QTL 1 (mouse)12603916060039160Mouse
4142433Hbnr1_mHeligmosomoides bakeri nematode resistance 1 (mouse)Not determined2555019158273271Mouse

Markers in Region
M20658  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38140,314,214 - 40,314,408UniSTSGRCm38
MGSCv37140,371,059 - 40,371,253UniSTSGRCm37
Celera140,125,390 - 40,125,584UniSTS
Cytogenetic Map1BUniSTS
cM Map119.5UniSTS
Whitehead/MRC_RH1632.86UniSTS
Whitehead_YAC1 UniSTS
RH94740  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38140,300,885 - 40,300,997UniSTSGRCm38
MGSCv37140,357,730 - 40,357,842UniSTSGRCm37
Celera140,112,106 - 40,112,218UniSTS
Cytogenetic Map1BUniSTS
cM Map119.5UniSTS
D1Mit232  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38140,262,417 - 40,262,558UniSTSGRCm38
MGSCv37140,319,262 - 40,319,403UniSTSGRCm37
Celera140,073,926 - 40,074,072UniSTS
Cytogenetic Map1BUniSTS
cM Map120.8UniSTS
Whitehead Genetic119.7UniSTS
Whitehead/MRC_RH1632.86UniSTS
Whitehead_YAC1 UniSTS
Il1r1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1BUniSTS
cM Map119.5UniSTS
cM Map119.5UniSTS
cM Map119.5UniSTS
Il1r1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1BUniSTS
M20658  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38140,315,573 - 40,315,669UniSTSGRCm38
MGSCv37140,372,418 - 40,372,514UniSTSGRCm37
Celera140,126,749 - 40,126,845UniSTS
Cytogenetic Map1BUniSTS
Whitehead/MRC_RH1632.86UniSTS
Il1r1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1BUniSTS
cM Map119.5UniSTS
Il1r1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1BUniSTS
cM Map119.5UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001123382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006495713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006495714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006495722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006495723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030250619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036162165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036162178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036162185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036162186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036162188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036162195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036162197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC135085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC167168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK048550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK054137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC109135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M20658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000027241   ⟹   ENSMUSP00000027241
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl140,264,240 - 40,356,417 (+)Ensembl
GRCm38.p6 Ensembl140,225,080 - 40,317,257 (+)Ensembl
Ensembl Acc Id: ENSMUST00000114795   ⟹   ENSMUSP00000110443
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl140,305,746 - 40,355,361 (+)Ensembl
GRCm38.p6 Ensembl140,266,586 - 40,316,201 (+)Ensembl
Ensembl Acc Id: ENSMUST00000195402
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl140,305,817 - 40,316,338 (+)Ensembl
GRCm38.p6 Ensembl140,266,657 - 40,277,178 (+)Ensembl
RefSeq Acc Id: NM_001123382   ⟹   NP_001116854
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39140,305,746 - 40,355,330 (+)NCBI
GRCm38140,266,586 - 40,316,177 (+)NCBI
MGSCv37140,281,925 - 40,373,022 (+)RGD
Celera140,033,653 - 40,127,353 (+)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_008362   ⟹   NP_032388
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39140,264,218 - 40,355,330 (+)NCBI
GRCm38140,225,080 - 40,316,177 (+)NCBI
MGSCv37140,281,925 - 40,373,022 (+)RGD
Celera140,033,653 - 40,127,353 (+)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006495713   ⟹   XP_006495776
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39140,261,651 - 40,355,361 (+)NCBI
GRCm38140,222,480 - 40,316,201 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006495714   ⟹   XP_006495777
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39140,305,700 - 40,355,361 (+)NCBI
GRCm38140,266,523 - 40,316,201 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006495722   ⟹   XP_006495785
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39140,264,138 - 40,355,361 (+)NCBI
GRCm38140,224,478 - 40,316,201 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006495723   ⟹   XP_006495786
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39140,286,542 - 40,355,361 (+)NCBI
GRCm38140,247,356 - 40,316,201 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030250619   ⟹   XP_030106479
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39140,264,142 - 40,355,361 (+)NCBI
GRCm38140,224,479 - 40,316,201 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036162165   ⟹   XP_036018058
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39140,305,700 - 40,355,361 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036162178   ⟹   XP_036018071
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39140,305,700 - 40,355,361 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036162185   ⟹   XP_036018078
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39140,264,174 - 40,355,361 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036162186   ⟹   XP_036018079
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39140,264,174 - 40,355,361 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036162188   ⟹   XP_036018081
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39140,305,700 - 40,355,361 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036162195   ⟹   XP_036018088
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39140,289,804 - 40,355,361 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036162197   ⟹   XP_036018090
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39140,264,174 - 40,355,361 (+)NCBI
Sequence:
RefSeq Acc Id: NP_032388   ⟸   NM_008362
- Peptide Label: isoform 1 precursor
- UniProtKB: P13504 (UniProtKB/Swiss-Prot),   Q32MH0 (UniProtKB/TrEMBL),   Q8C6P3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001116854   ⟸   NM_001123382
- Peptide Label: isoform 2 precursor
- UniProtKB: Q8C6P3 (UniProtKB/TrEMBL),   Q8C833 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006495776   ⟸   XM_006495713
- Peptide Label: isoform X1
- UniProtKB: P13504 (UniProtKB/Swiss-Prot),   Q32MH0 (UniProtKB/TrEMBL),   Q8C6P3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006495785   ⟸   XM_006495722
- Peptide Label: isoform X2
- UniProtKB: Q8C833 (UniProtKB/TrEMBL),   Q8C6P3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006495786   ⟸   XM_006495723
- Peptide Label: isoform X2
- UniProtKB: Q8C833 (UniProtKB/TrEMBL),   Q8C6P3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006495777   ⟸   XM_006495714
- Peptide Label: isoform X2
- UniProtKB: Q8C833 (UniProtKB/TrEMBL),   Q8C6P3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030106479   ⟸   XM_030250619
- Peptide Label: isoform X2
- UniProtKB: Q8C833 (UniProtKB/TrEMBL),   Q8C6P3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000027241   ⟸   ENSMUST00000027241
Ensembl Acc Id: ENSMUSP00000110443   ⟸   ENSMUST00000114795
RefSeq Acc Id: XP_036018078   ⟸   XM_036162185
- Peptide Label: isoform X2
- UniProtKB: Q8C833 (UniProtKB/TrEMBL),   Q8C6P3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036018090   ⟸   XM_036162197
- Peptide Label: isoform X2
- UniProtKB: Q8C833 (UniProtKB/TrEMBL),   Q8C6P3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036018079   ⟸   XM_036162186
- Peptide Label: isoform X2
- UniProtKB: Q8C833 (UniProtKB/TrEMBL),   Q8C6P3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036018088   ⟸   XM_036162195
- Peptide Label: isoform X2
- UniProtKB: Q8C833 (UniProtKB/TrEMBL),   Q8C6P3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036018071   ⟸   XM_036162178
- Peptide Label: isoform X2
- UniProtKB: Q8C833 (UniProtKB/TrEMBL),   Q8C6P3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036018058   ⟸   XM_036162165
- Peptide Label: isoform X2
- UniProtKB: Q8C833 (UniProtKB/TrEMBL),   Q8C6P3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036018081   ⟸   XM_036162188
- Peptide Label: isoform X2
- UniProtKB: Q8C833 (UniProtKB/TrEMBL),   Q8C6P3 (UniProtKB/TrEMBL)
Protein Domains
Ig-like   Ig-like C2-type   TIR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P13504-F1-model_v2 AlphaFold P13504 1-576 view protein structure

Promoters
RGD ID:6873556
Promoter ID:EPDNEW_M229
Type:initiation region
Name:Il1r1_2
Description:Mus musculus interleukin 1 receptor, type I , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M230  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38140,225,112 - 40,225,172EPDNEW
RGD ID:6873558
Promoter ID:EPDNEW_M230
Type:initiation region
Name:Il1r1_1
Description:Mus musculus interleukin 1 receptor, type I , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M229  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38140,266,621 - 40,266,681EPDNEW
RGD ID:6817936
Promoter ID:MM_KWN:557
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   Liver
Transcripts:NM_008362
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36140,281,759 - 40,282,259 (+)MPROMDB
RGD ID:6817932
Promoter ID:MM_KWN:558
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day6,   Liver,   Lung,   MEF_B4,   Spleen
Transcripts:ENSMUST00000114795
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36140,323,416 - 40,323,916 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96545 AgrOrtholog
Ensembl Genes ENSMUSG00000026072 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000027241 ENTREZGENE
  ENSMUST00000027241.11 UniProtKB/Swiss-Prot
  ENSMUST00000114795 ENTREZGENE
  ENSMUST00000114795.3 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.10140 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-1_rcpt_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-1_rcpt_I-typ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-1_rcpt_I/II-typ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Toll_tir_struct_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16177 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:96545 ENTREZGENE
NCBI Gene 16177 ENTREZGENE
PANTHER INTERLEUKIN-1 RECEPTOR TYPE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11890 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB IL1R1 RGD
PhenoGen Il1r1 PhenoGen
PRINTS INTRLEUKN1R1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTRLKN1R12F UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTRLKN1R1F UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt IL1R1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q32MH0 ENTREZGENE, UniProtKB/TrEMBL
  Q8C6P3 ENTREZGENE, UniProtKB/TrEMBL
  Q8C833 ENTREZGENE, UniProtKB/TrEMBL