Prkab1 (protein kinase, AMP-activated, beta 1 non-catalytic subunit) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Prkab1 (protein kinase, AMP-activated, beta 1 non-catalytic subunit) Mus musculus
Analyze
Symbol: Prkab1
Name: protein kinase, AMP-activated, beta 1 non-catalytic subunit
RGD ID: 735403
MGI Page MGI
Description: Predicted to enable protein kinase activity and protein kinase binding activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within nail development. Located in nucleus. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and hemolymphoid system. Orthologous to human PRKAB1 (protein kinase AMP-activated non-catalytic subunit beta 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1300015D22Rik; 5'-AMP-activated protein kinase subunit beta-1; AMPK subunit beta-1; AMPKb; AU021155; E430008F22
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395116,151,654 - 116,162,449 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5116,151,645 - 116,162,567 (-)EnsemblGRCm39 Ensembl
GRCm385116,013,586 - 116,024,503 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5116,013,586 - 116,024,508 (-)EnsemblGRCm38mm10GRCm38
MGSCv375116,463,599 - 116,474,437 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365116,274,589 - 116,285,427 (-)NCBIMGSCv36mm8
Celera5113,114,056 - 113,125,788 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map556.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (EXP)
(S)-colchicine  (ISO)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,6-dinitrotoluene  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-vinylcyclohexene dioxide  (EXP)
acrolein  (ISO)
actinomycin D  (ISO)
adenine  (ISO)
aflatoxin B1  (EXP,ISO)
alpha-pinene  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (EXP)
atrazine  (EXP)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
camptothecin  (ISO)
captan  (EXP)
carbon nanotube  (EXP)
chloroacetaldehyde  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clofibrate  (EXP,ISO)
copper(II) sulfate  (ISO)
cordycepin  (EXP)
crocin-1  (ISO)
Curcumol  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP)
Dibutyl phosphate  (ISO)
diethyl maleate  (EXP)
dioscin  (ISO)
dioxygen  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenofibrate  (EXP,ISO)
flutamide  (ISO)
folic acid  (EXP)
folpet  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (ISO)
hydrogen sulfide  (EXP)
hydroxyurea  (ISO)
ifosfamide  (ISO)
leflunomide  (ISO)
levonorgestrel  (ISO)
lycopene  (EXP)
methyl methanesulfonate  (ISO)
morin  (ISO)
nefazodone  (ISO)
nicotine  (EXP)
nimesulide  (ISO)
Nutlin-3  (ISO)
oxycodone  (ISO)
ozone  (ISO)
paracetamol  (EXP)
parathion  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (EXP,ISO)
quercetin  (EXP,ISO)
rotenone  (ISO)
sodium arsenite  (ISO)
testosterone  (EXP)
testosterone undecanoate  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (EXP)
valproic acid  (ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA)
cytosol  (TAS)
nucleotide-activated protein kinase complex  (IBA,IEA,ISO,ISS)
nucleus  (IBA,IDA,IEA,ISO)
protein-containing complex  (IEA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal astrocyte morphology  (IAGP)
abnormal axon morphology  (IAGP)
abnormal bone marrow morphology  (IAGP)
abnormal cerebellum morphology  (IAGP)
abnormal cerebral cortex morphology  (IAGP)
abnormal dendrite morphology  (IAGP)
abnormal dentate gyrus morphology  (IAGP)
abnormal ductus venosus morphology  (IEA)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal epididymis morphology  (IEA)
abnormal erythrocyte morphology  (IAGP)
abnormal erythropoiesis  (IAGP)
abnormal freezing behavior  (IEA)
abnormal hepatocyte physiology  (IAGP)
abnormal inferior vena cava morphology  (IEA)
abnormal kidney morphology  (IEA)
abnormal lens morphology  (IEA)
abnormal lipid level  (IAGP)
abnormal myelination  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal neuronal precursor proliferation  (IAGP)
abnormal optic nerve morphology  (IAGP)
abnormal reticulocyte cell number  (IAGP)
abnormal retina blood vessel morphology  (IEA)
abnormal retina inner nuclear layer morphology  (IEA)
abnormal retina vasculature morphology  (IEA)
abnormal skeletal muscle morphology  (IAGP)
abnormal spleen morphology  (IEA)
abnormal testis morphology  (IEA)
absent cerebellar granule layer  (IAGP)
absent pinna reflex  (IEA)
acanthocytosis  (IAGP)
anisocytosis  (IAGP)
anophthalmia  (IEA)
astrocytosis  (IAGP)
ataxia  (IAGP)
brain vacuoles  (IAGP)
cataract  (IEA)
cerebellum atrophy  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral content  (IEA)
decreased bone mineral density  (IEA)
decreased brain size  (IAGP)
decreased cerebellar granule cell number  (IAGP)
decreased circulating amylase level  (IEA)
decreased circulating chloride level  (IEA)
decreased circulating cholesterol level  (IEA)
decreased circulating HDL cholesterol level  (IEA)
decreased circulating insulin level  (IAGP)
decreased circulating interleukin-6 level  (IAGP)
decreased circulating iron level  (IAGP)
decreased circulating LDL cholesterol level  (IEA)
decreased circulating leptin level  (IAGP)
decreased circulating magnesium level  (IEA)
decreased circulating phosphate level  (IEA)
decreased epididymal fat pad weight  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased erythrocyte osmotic fragility  (IAGP)
decreased fasting circulating glucose level  (IEA)
decreased food intake  (IAGP)
decreased grip strength  (IEA)
decreased hematocrit  (IAGP)
decreased hemoglobin content  (IAGP)
decreased kidney weight  (IEA)
decreased liver triglyceride level  (IAGP)
decreased locomotor activity  (IAGP)
decreased lung elastance  (IEA)
decreased Ly6C-positive mature NK cell number  (IEA)
decreased lymphocyte cell number  (IEA)
decreased mean corpuscular hemoglobin  (IEA)
decreased mean corpuscular hemoglobin concentration  (IAGP)
decreased mean corpuscular volume  (IEA)
decreased muscle cell glucose uptake  (IAGP)
decreased neuron number  (IAGP)
decreased oligodendrocyte number  (IAGP)
decreased susceptibility to diet-induced hepatic steatosis  (IAGP)
decreased susceptibility to diet-induced obesity  (IAGP)
decreased total retina thickness  (IEA)
echinocytosis  (IAGP)
enlarged epididymis  (IEA)
enlarged heart  (IEA)
enlarged kidney  (IEA)
enlarged spleen  (IAGP)
enlarged testis  (IEA)
extramedullary hematopoiesis  (IAGP)
hemolytic anemia  (IAGP)
impaired contextual conditioning behavior  (IEA)
impaired exercise endurance  (IAGP)
impaired glucose tolerance  (IEA)
increased circulating alanine transaminase level  (IEA)
increased circulating alkaline phosphatase level  (IEA)
increased circulating bilirubin level  (IEA)
increased circulating erythropoietin level  (IAGP)
increased circulating ferritin level  (IAGP)
increased circulating glucose level  (IAGP)
increased erythroblast number  (IAGP)
increased erythroid progenitor cell number  (IAGP)
increased fasting circulating glucose level  (IEA)
increased glycosylated hemoglobin level  (IEA)
increased heart rate  (IEA)
increased heart weight  (IEA)
increased insulin sensitivity  (IAGP)
increased lung compliance  (IEA)
increased mean platelet volume  (IAGP)
increased memory-marker CD4-negative NK T cell number  (IEA)
increased memory-marker gamma-delta T cell number  (IEA)
increased muscle fatigability  (IAGP)
increased neutrophil cell number  (IEA)
increased red blood cell distribution width  (IAGP)
increased spleen iron level  (IAGP)
increased spleen red pulp amount  (IAGP)
increased spleen weight  (IAGP)
lethality, complete penetrance  (IAGP)
loss of hippocampal neurons  (IAGP)
microcytic anemia  (IAGP)
microcytosis  (IAGP)
no abnormal phenotype detected  (IEA)
no spontaneous movement  (IEA)
optic nerve hypoplasia  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
preweaning lethality, incomplete penetrance  (IEA)
reticulocytosis  (IAGP)
schistocytosis  (IAGP)
seizures  (IAGP)
shortened RR interval  (IEA)
slow postnatal weight gain  (IAGP)
stomatocytosis  (IAGP)
tremors  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Expression of the AMP-activated protein kinase beta1 and beta2 subunits in skeletal muscle. Chen Z, etal., FEBS Lett 1999 Oct 29;460(2):343-8.
2. Renoprotective Effects of Metformin are Independent of Organic Cation Transporters 1 &2 and AMP-activated Protein Kinase in the Kidney. Christensen M, etal., Sci Rep. 2016 Oct 26;6:35952. doi: 10.1038/srep35952.
3. The AMP-activated protein kinase pathway--new players upstream and downstream. Hardie DG J Cell Sci. 2004 Nov 1;117(Pt 23):5479-87.
4. Management of cellular energy by the AMP-activated protein kinase system. Hardie DG, etal., FEBS Lett. 2003 Jul 3;546(1):113-20.
5. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
6. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
7. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
8. MGDs mouse GO annotations MGD data from the GO Consortium
9. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. Mouse MP Annotation Import Pipeline RGD automated import pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:9693118   PMID:10098881   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12520002   PMID:15226823   PMID:15489334   PMID:15782199  
PMID:15886229   PMID:16141072   PMID:16141073   PMID:17525164   PMID:17711846   PMID:17767908   PMID:18006825   PMID:18390901   PMID:18480843   PMID:19050047   PMID:19217427   PMID:19723702  
PMID:19892703   PMID:20196784   PMID:20231899   PMID:20368287   PMID:20421294   PMID:20708602   PMID:20861022   PMID:21460634   PMID:21677750   PMID:21873635   PMID:21896769   PMID:22080866  
PMID:22135324   PMID:22253816   PMID:23055939   PMID:23785098   PMID:23963743   PMID:24185692   PMID:24194600   PMID:24425763   PMID:24522207   PMID:24808538   PMID:24864274   PMID:25195104  
PMID:25340873   PMID:25773887   PMID:25940306   PMID:26023060   PMID:26034200   PMID:26039451   PMID:26332085   PMID:26398943   PMID:26517695   PMID:26952277   PMID:26961958   PMID:27411013  
PMID:27467571   PMID:27554471   PMID:27626380   PMID:27666489   PMID:27941154   PMID:28185240   PMID:28389470   PMID:28544264   PMID:29316805   PMID:29401588   PMID:29688375   PMID:29915361  
PMID:30242113   PMID:30973865   PMID:31162135   PMID:31581839   PMID:31782497   PMID:32510137   PMID:32611235   PMID:32694673   PMID:32719536   PMID:32877674   PMID:33252129   PMID:33493298  
PMID:34425254   PMID:35670459   PMID:36409897   PMID:36543129   PMID:37239114   PMID:37428711   PMID:38026185   PMID:38355793   PMID:38822427  


Genomics

Comparative Map Data
Prkab1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395116,151,654 - 116,162,449 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5116,151,645 - 116,162,567 (-)EnsemblGRCm39 Ensembl
GRCm385116,013,586 - 116,024,503 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5116,013,586 - 116,024,508 (-)EnsemblGRCm38mm10GRCm38
MGSCv375116,463,599 - 116,474,437 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365116,274,589 - 116,285,427 (-)NCBIMGSCv36mm8
Celera5113,114,056 - 113,125,788 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map556.1NCBI
PRKAB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812119,667,952 - 119,681,619 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12119,667,864 - 119,681,624 (+)EnsemblGRCh38hg38GRCh38
GRCh3712120,105,938 - 120,119,424 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612118,590,144 - 118,603,812 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412118,568,480 - 118,582,148NCBI
Celera12119,738,816 - 119,752,482 (+)NCBICelera
Cytogenetic Map12q24.23NCBI
HuRef12117,113,891 - 117,127,561 (+)NCBIHuRef
CHM1_112120,073,269 - 120,086,937 (+)NCBICHM1_1
T2T-CHM13v2.012119,655,225 - 119,668,903 (+)NCBIT2T-CHM13v2.0
Prkab1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81246,248,971 - 46,259,487 (+)NCBIGRCr8
GRCr8 Ensembl1246,249,010 - 46,259,482 (+)EnsemblGRCr8 Ensembl
mRatBN7.21240,588,140 - 40,598,673 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1240,588,211 - 40,598,661 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1241,761,540 - 41,771,903 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01242,375,265 - 42,385,628 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01241,435,725 - 41,446,088 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01246,316,298 - 46,326,789 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1246,316,236 - 46,326,790 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01248,117,478 - 48,127,960 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41241,840,866 - 41,851,241 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1242,217,411 - 42,227,786 (+)NCBICelera
RGSC_v3.11241,704,253 - 41,714,629 (+)NCBI
Cytogenetic Map12q16NCBI
Prkab1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545511,876,661 - 11,890,069 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545511,877,407 - 11,889,987 (-)NCBIChiLan1.0ChiLan1.0
PRKAB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210127,733,557 - 127,747,256 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112127,729,754 - 127,743,635 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012117,246,691 - 117,260,465 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112120,624,004 - 120,637,585 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12120,624,004 - 120,637,585 (+)Ensemblpanpan1.1panPan2
PRKAB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12615,706,583 - 15,716,612 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2615,706,678 - 15,715,314 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2615,711,405 - 15,721,444 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02615,974,145 - 15,984,177 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2615,974,172 - 15,984,165 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12615,944,207 - 15,954,235 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02616,012,374 - 16,022,410 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02616,053,316 - 16,063,357 (+)NCBIUU_Cfam_GSD_1.0
Prkab1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118146,654,905 - 146,666,590 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366681,152,929 - 1,165,576 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366681,153,791 - 1,165,469 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKAB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1433,201,669 - 33,217,539 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11433,201,359 - 33,217,641 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21435,147,989 - 35,163,200 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRKAB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111115,008,306 - 115,021,348 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11115,008,313 - 115,023,373 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037130,084,721 - 130,097,957 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkab1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474713,922,685 - 13,935,912 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474713,923,315 - 13,935,397 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prkab1
623 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1782
Count of miRNA genes:698
Interacting mature miRNAs:882
Transcripts:ENSMUST00000031486, ENSMUST00000111999, ENSMUST00000133098, ENSMUST00000141018, ENSMUST00000143146, ENSMUST00000143524, ENSMUST00000147343, ENSMUST00000148208, ENSMUST00000152174
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301399Cpfd3_mcerebellum pattern fissures (mouse)Not determined587386871121387065Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574460661132528839Mouse
1357725Eae39_mexperimental allergic encephalomyelitis 39 (mouse)Not determined589418876118864028Mouse
14746986Manh58_mmandible shape 58 (mouse)5102446283136446283Mouse
1300993Hycdc_mhypercapnic duty cycle (mouse)Not determined590561006124561151Mouse
1301126Bwem1_mbody weight day 30 males 1 (mouse)Not determined587386871121387065Mouse
1300659Pcd8ts1_mp-glycoprotein positive CD8 T cell subset 1 (mouse)Not determined597021753131021986Mouse
1301042Elmaz1_melevated maze behavior 1 (mouse)Not determined598019649116876624Mouse
1300913Bwefm_mbody weight females and males day 10 (mouse)Not determined5109439348143439459Mouse
10402486Dipa1_mdrug induced psychomotor activation 1 (mouse)Not determined595465549129465722Mouse
10043958Chldq12_mcholesterol and HDL QTL 12 (mouse)Not determined587386871121387065Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)570057343132528839Mouse
10412202Bbaa26_mB.burgdorferi-associated arthritis 26 (mouse)Not determined5104583688138555455Mouse
1301543Hypch_mhypercholesterolemia (mouse)Not determined5109238624139118905Mouse
12904945Tammq2_mtibialis anterior muscle mass QTL 2 (mouse)5100665965134665965Mouse
4142473Chlq11_mcirculating hormone level QTL 11 (mouse)Not determined5107906299141906412Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
12904959Smmq1_msoleus muscle mass QTL 1 (mouse)5100665965134665965Mouse
10412197Bbaa25_mB.burgdorferi-associated arthritis 25 (mouse)Not determined5109167240143167381Mouse
13506928Recrq8_mrecombination rate in male meiosis QTL 8 (mouse)574460661132528839Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
1301457Cfsw2_mcystic fibrosis survival to weaning 2 (mouse)Not determined590561006124561151Mouse
10401245Bglu18_mblood glucose level 18 (mouse)Not determined582838468116838597Mouse
1301974Chab7_mcholesterol absorption 7 (mouse)Not determined595233214129233330Mouse
1300827Cora1_mcorrelation in cytokine production 1 (mouse)Not determined5115156883149157015Mouse
11528550Sluc33_msusceptibility to lung cancer 33 (mouse)5104386871120711986Mouse
1357662Lprq4_mlipoprotein QTL 4 (mouse)Not determined5114021753129632606Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554500177127001072Mouse
10412239Alpq7_malcohol preference QTL 7 (mouse)Not determined5104705939138705939Mouse
1300801Drb2_mdopamine receptor binding 2 (mouse)Not determined587386871121387065Mouse
9587780Afw16_mabdominal fat weight QTL 16 (mouse)Not determined592830166126830285Mouse
1357644Egrd1_mearly growth rate, direct effect 1 (mouse)Not determined595434580129434786Mouse
12859290Criq2_mCitrobacter rodentium infection QTL 2 (mouse)5101332579135332579Mouse
1300940Actd3_mactivity-distance traveled 3 (mouse)Not determined596320385130320533Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
1558774Lith17_mlithogenic gene 17 (mouse)Not determined595465549129465722Mouse
1357431Cia27_mcollagen induced arthritis 27 (mouse)Not determined575315348120018629Mouse
1301624Aevm2_mautoimmune extremity vasculitis in MRL mice 2 (mouse)Not determined5101863832135864028Mouse
10043890Trigq4_mtriglyceride QTL 4 (mouse)Not determined5107906299141906412Mouse
4141652Mrdq2_mmodifier of retinal degeneration QTL 2 (mouse)Not determined110253106118093673Mouse
4141139Hmtb4_mhemostasis and thrombosis rebleeding time 4 (mouse)Not determined108762509126882944Mouse
11532736Sluc33b_msusceptibility to lung cancer 33b (mouse)5102945037136945196Mouse
4141519Hmtb5_mhemostasis and thrombosis bleeding time 5 (mouse)Not determined99949422126882944Mouse
1301858Smdq1_msegregation of mitochondrial DNA QTL 1 (mouse)Not determined597021753131021986Mouse
11049562Lmr24f_mleishmaniasis resistance 24f (mouse)590320962124321041Mouse
13464251Ahl21_mage related hearing loss, early onset 21 (mouse)5109167240143167381Mouse
13464244Ahl19_mage related hearing loss, early onset 19 (mouse)595465549129465722Mouse
1301226Bbaa2_mB.burgdorferi-associated arthritis 2 (mouse)Not determined5115156883149157015Mouse
1300968Skts4_mskin tumor susceptibility 4 (mouse)Not determined589418876124238239Mouse
13464241Ahl18_mage related hearing loss, early onset 18 (mouse)587386871121387065Mouse
1301102Cia14_mcollagen induced arthritis 14 (mouse)Not determined5113320385138555455Mouse
13464243Ahl20_mage related hearing loss, early onset 20 (mouse)5107906299141906412Mouse
13464242Ahl17_mage related hearing loss, early onset 17 (mouse)582838468116838597Mouse

Markers in Region
RH127243  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385116,013,609 - 116,013,858UniSTSGRCm38
MGSCv375116,463,618 - 116,463,867UniSTSGRCm37
Celera5113,114,075 - 113,114,324UniSTS
Cytogenetic Map5FUniSTS
Whitehead/MRC_RH51421.14UniSTS
RH136452  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385116,013,715 - 116,013,910UniSTSGRCm38
MGSCv375116,463,724 - 116,463,919UniSTSGRCm37
Celera5113,114,181 - 113,114,376UniSTS
Cytogenetic Map5FUniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000031486   ⟹   ENSMUSP00000031486
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5116,151,645 - 116,162,521 (-)Ensembl
GRCm38.p6 Ensembl5116,013,586 - 116,024,462 (-)Ensembl
Ensembl Acc Id: ENSMUST00000111999   ⟹   ENSMUSP00000107630
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5116,151,649 - 116,162,567 (-)Ensembl
GRCm38.p6 Ensembl5116,013,590 - 116,024,508 (-)Ensembl
Ensembl Acc Id: ENSMUST00000133098   ⟹   ENSMUSP00000138749
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5116,152,494 - 116,162,415 (-)Ensembl
GRCm38.p6 Ensembl5116,014,435 - 116,024,356 (-)Ensembl
Ensembl Acc Id: ENSMUST00000141018
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5116,157,766 - 116,159,705 (-)Ensembl
GRCm38.p6 Ensembl5116,019,707 - 116,021,646 (-)Ensembl
Ensembl Acc Id: ENSMUST00000143146
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5116,152,226 - 116,153,220 (-)Ensembl
GRCm38.p6 Ensembl5116,014,167 - 116,015,161 (-)Ensembl
Ensembl Acc Id: ENSMUST00000143524
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5116,152,375 - 116,156,270 (-)Ensembl
GRCm38.p6 Ensembl5116,014,316 - 116,018,211 (-)Ensembl
Ensembl Acc Id: ENSMUST00000147343
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5116,155,874 - 116,162,456 (-)Ensembl
GRCm38.p6 Ensembl5116,017,815 - 116,024,397 (-)Ensembl
Ensembl Acc Id: ENSMUST00000148208   ⟹   ENSMUSP00000138221
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5116,152,709 - 116,162,510 (-)Ensembl
GRCm38.p6 Ensembl5116,014,650 - 116,024,451 (-)Ensembl
Ensembl Acc Id: ENSMUST00000152174
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5116,161,958 - 116,162,518 (-)Ensembl
GRCm38.p6 Ensembl5116,023,899 - 116,024,459 (-)Ensembl
RefSeq Acc Id: NM_001417558   ⟹   NP_001404487
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395116,151,654 - 116,162,449 (-)NCBI
RefSeq Acc Id: NM_031869   ⟹   NP_114075
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395116,151,654 - 116,162,449 (-)NCBI
GRCm385116,013,590 - 116,024,428 (-)NCBI
MGSCv375116,463,599 - 116,474,437 (-)RGD
Celera5113,114,056 - 113,125,788 (-)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_184530
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395116,151,654 - 116,162,449 (-)NCBI
RefSeq Acc Id: NP_114075   ⟸   NM_031869
- UniProtKB: Q91YN6 (UniProtKB/Swiss-Prot),   Q9R078 (UniProtKB/Swiss-Prot),   Q542K0 (UniProtKB/TrEMBL),   Q3U5I9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000107630   ⟸   ENSMUST00000111999
Ensembl Acc Id: ENSMUSP00000031486   ⟸   ENSMUST00000031486
Ensembl Acc Id: ENSMUSP00000138749   ⟸   ENSMUST00000133098
Ensembl Acc Id: ENSMUSP00000138221   ⟸   ENSMUST00000148208
RefSeq Acc Id: NP_001404487   ⟸   NM_001417558
- UniProtKB: Q9R078 (UniProtKB/Swiss-Prot),   Q91YN6 (UniProtKB/Swiss-Prot),   Q542K0 (UniProtKB/TrEMBL),   Q3U5I9 (UniProtKB/TrEMBL)
Protein Domains
AMP-activated protein kinase glycogen-binding   Association with the SNF1 complex (ASC)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R078-F1-model_v2 AlphaFold Q9R078 1-270 view protein structure

Promoters
RGD ID:6887782
Promoter ID:EPDNEW_M7342
Type:initiation region
Name:Prkab1_1
Description:Mus musculus protein kinase, AMP-activated, beta 1 non-catalyticsubunit , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385116,024,385 - 116,024,445EPDNEW
RGD ID:6838101
Promoter ID:MM_KWN:43709
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Lung,   Spleen
Transcripts:OTTMUST00000034940
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365116,464,676 - 116,465,512 (-)MPROMDB
RGD ID:6838098
Promoter ID:MM_KWN:43711
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Spleen
Transcripts:OTTMUST00000034938
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365116,471,576 - 116,472,076 (-)MPROMDB
RGD ID:6838097
Promoter ID:MM_KWN:43712
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000111999,   OTTMUST00000034932,   OTTMUST00000034934,   OTTMUST00000034935,   OTTMUST00000034936,   OTTMUST00000034937
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365116,474,301 - 116,474,801 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1336167 AgrOrtholog
Ensembl Genes ENSMUSG00000029513 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000031486 ENTREZGENE
  ENSMUST00000031486.14 UniProtKB/Swiss-Prot
  ENSMUST00000111999 ENTREZGENE
  ENSMUST00000111999.8 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
  6.20.250.60 UniProtKB/Swiss-Prot
InterPro AMPK1_CBM UniProtKB/Swiss-Prot
  ASC_dom UniProtKB/Swiss-Prot
  ASC_dom_sf UniProtKB/Swiss-Prot
  CRP1_MDG1_kinase UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_E-set UniProtKB/Swiss-Prot
KEGG Report mmu:19079 UniProtKB/Swiss-Prot
MGD MGI:1336167 ENTREZGENE
NCBI Gene 19079 ENTREZGENE
PANTHER 5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT UniProtKB/Swiss-Prot
  5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1 UniProtKB/Swiss-Prot
Pfam AMPK1_CBM UniProtKB/Swiss-Prot
  AMPKBI UniProtKB/Swiss-Prot
PhenoGen Prkab1 PhenoGen
SMART AMPKBI UniProtKB/Swiss-Prot
Superfamily-SCOP SSF160219 UniProtKB/Swiss-Prot
  SSF81296 UniProtKB/Swiss-Prot
UniProt AAKB1_MOUSE UniProtKB/Swiss-Prot
  Q3U5I9 ENTREZGENE, UniProtKB/TrEMBL
  Q542K0 ENTREZGENE, UniProtKB/TrEMBL
  Q91YN6 ENTREZGENE
  Q9R078 ENTREZGENE
  S4R2R1_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q91YN6 UniProtKB/Swiss-Prot