Cdk6 (cyclin dependent kinase 6) - Rat Genome Database

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Gene: Cdk6 (cyclin dependent kinase 6) Mus musculus
Analyze
Symbol: Cdk6
Name: cyclin dependent kinase 6
RGD ID: 735401
MGI Page MGI
Description: Enables kinase activity. Involved in hemopoiesis. Acts upstream of or within several processes, including hemopoiesis; regulation of gene expression; and regulation of hematopoietic stem cell differentiation. Part of cyclin D2-CDK6 complex. Is expressed in several structures, including alimentary system; central nervous system; forelimb bud; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in high grade glioma; lung non-small cell carcinoma; pancreatic adenocarcinoma; pancreatic ductal carcinoma; and primary autosomal recessive microcephaly 12. Orthologous to human CDK6 (cyclin dependent kinase 6).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 5830411I20; AI504062; cell division protein kinase 6; CR2 protein kinase; Crk; Crk2; cyclin-dependent kinase 6; serine/threonine-protein kinase PLSTIRE
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm11786  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3953,391,004 - 3,581,008 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl53,391,485 - 3,581,008 (+)EnsemblGRCm39 Ensembl
GRCm3853,341,004 - 3,531,008 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl53,341,485 - 3,531,008 (+)EnsemblGRCm38mm10GRCm38
MGSCv3753,344,312 - 3,522,225 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3653,350,318 - 3,528,231 (+)NCBIMGSCv36mm8
Celera53,279,311 - 3,457,786 (+)NCBICelera
Cytogenetic Map5A1NCBI
cM Map52.04NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
(Z)-3-butylidenephthalide  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
2,4-D  (EXP)
2-methylcholine  (ISO)
3,3'-diindolylmethane  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP)
4-nitrophenol  (EXP)
5-aza-2'-deoxycytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
acrolein  (ISO)
acteoside  (ISO)
adefovir pivoxil  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
aniline  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
betulinic acid  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
BMS-754807  (ISO)
Butylparaben  (ISO)
butyric acid  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
camptothecin  (ISO)
cannabidiol  (EXP,ISO)
cantharidin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (EXP)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
choline  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
cobalt dichloride  (ISO)
columbamine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coptisine  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP)
deguelin  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
diclofenac  (ISO)
dieckol  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
dioscin  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (ISO)
dronedarone  (ISO)
embelin  (ISO)
endosulfan  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (EXP)
erlotinib hydrochloride  (ISO)
ethyl methanesulfonate  (ISO)
eugenol  (ISO)
fenpyroximate  (ISO)
fenthion  (EXP)
fenvalerate  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
fulvestrant  (ISO)
furazolidone  (ISO)
galangin  (ISO)
gefitinib  (ISO)
geldanamycin  (ISO)
genistein  (ISO)
glyphosate  (ISO)
hesperidin  (ISO)
hypochlorous acid  (EXP)
ibuprofen  (ISO)
ifosfamide  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
isoeugenol  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (EXP)
lidocaine  (ISO)
lipopolysaccharide  (EXP,ISO)
mercury dibromide  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methidathion  (EXP)
methotrexate  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
microcystin-LR  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
ouabain  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
palbociclib  (EXP,ISO)
Panduratin A  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
piperine  (EXP)
pirinixic acid  (ISO)
platycodin D  (ISO)
ponatinib  (ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP,ISO)
propylparaben  (ISO)
quercetin  (ISO)
quizartinib  (ISO)
ranitidine  (ISO)
resveratrol  (EXP,ISO)
ritonavir  (ISO)
rottlerin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
SB 203580  (ISO)
SB 431542  (ISO)
seliciclib  (ISO)
silibinin  (ISO)
sodium arsenite  (EXP,ISO)
sorafenib  (ISO)
sulforaphane  (EXP)
sulindac  (ISO)
tamoxifen  (EXP)
tebufenpyrad  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetracaine  (ISO)
tetrachloromethane  (EXP)
thimerosal  (ISO)
thioacetamide  (ISO)
torcetrapib  (ISO)
trans-isoeugenol  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (EXP)
Triptolide  (EXP)
troglitazone  (ISO)
Tryptanthrine  (ISO)
tunicamycin  (EXP)
usnic acid  (ISO)
valproic acid  (EXP,ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vancomycin  (EXP)
venetoclax  (ISO)
vinclozolin  (ISO)
vismodegib  (EXP)
vorinostat  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal common myeloid progenitor cell morphology  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal erythrocyte morphology  (IAGP)
abnormal eye morphology  (IEA)
abnormal gametogenesis  (IAGP)
abnormal hematopoietic stem cell physiology  (IAGP)
abnormal hematopoietic system morphology/development  (IAGP)
abnormal lymphopoiesis  (IAGP)
abnormal oogenesis  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal spleen red pulp morphology  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal thymocyte activation  (IAGP)
abnormal thymus morphology  (IAGP)
decreased body weight  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased cell proliferation  (IAGP)
decreased DN1 thymic pro-T cell number  (IAGP)
decreased DN2 thymocyte number  (IAGP)
decreased DN4 thymocyte number  (IAGP)
decreased double-negative T cell number  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased embryo size  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased hematopoietic stem cell number  (IAGP)
decreased leukocyte cell number  (IAGP)
decreased mature ovarian follicle number  (IAGP)
decreased megakaryocyte cell number  (IAGP)
decreased myocardial fiber number  (IAGP)
decreased T cell proliferation  (IAGP)
decreased thymocyte apoptosis  (IAGP)
decreased thymocyte number  (IAGP)
decreased tumor-free survival time  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
enlarged thymus  (IAGP)
extramedullary hematopoiesis  (IAGP)
increased adenoma incidence  (IAGP)
increased CD4-positive, alpha-beta T cell number  (IAGP)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased DN1 thymic pro-T cell number  (IAGP)
increased DN3 thymocyte number  (IAGP)
increased double-negative T cell number  (IAGP)
increased hematopoietic stem cell number  (IAGP)
increased lung non-small cell carcinoma incidence  (IAGP)
increased mean corpuscular hemoglobin  (IEA)
increased mean corpuscular hemoglobin concentration  (IAGP)
increased mean corpuscular volume  (IAGP)
increased single-positive T cell number  (IAGP)
increased T cell apoptosis  (IAGP)
increased T cell derived lymphoma incidence  (IAGP)
increased thymocyte number  (IAGP)
infertility  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
liver hypoplasia  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
reduced female fertility  (IAGP)
small spleen  (IAGP)
small superior vagus ganglion  (IEA)
small thymus  (IAGP)
spleen hypoplasia  (IAGP)
thin ventricular wall  (IAGP)
thymus atrophy  (IAGP)
thymus cortex atrophy  (IAGP)
thymus hypoplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Cyclin-dependent kinase 6 (CDK6) amplification in human gliomas identified using two-dimensional separation of genomic DNA. Costello JF, etal., Cancer Res. 1997 Apr 1;57(7):1250-4.
2. Rottlerin suppresses growth of human pancreatic tumors in nude mice, and pancreatic cancer cells isolated from Kras(G12D) mice. Huang M, etal., Cancer Lett. 2014 Oct 10;353(1):32-40. doi: 10.1016/j.canlet.2014.06.021. Epub 2014 Jul 19.
3. Activation of cyclin D1-related kinase in human lung adenocarcinoma. Igarashi K, etal., Br J Cancer. 1999 Oct;81(4):705-11. doi: 10.1038/sj.bjc.6690752.
4. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
5. Transcriptional alterations in hereditary and sporadic nonfunctioning pancreatic neuroendocrine tumors according to genotype. Keutgen XM, etal., Cancer. 2018 Feb 1;124(3):636-647. doi: 10.1002/cncr.31057. Epub 2017 Nov 17.
6. Expression of p19INK4d, CDK4, CDK6 in glioblastoma multiforme. Lam PY, etal., Br J Neurosurg. 2000 Feb;14(1):28-32.
7. Knockdown of CDK6 enhances glioma sensitivity to chemotherapy. Li B, etal., Oncol Rep. 2012 Sep;28(3):909-14. doi: 10.3892/or.2012.1884. Epub 2012 Jun 25.
8. Mammalian cyclin-dependent kinases. Malumbres M and Barbacid M, Trends Biochem Sci. 2005 Nov;30(11):630-41. Epub 2005 Oct 19.
9. Embelin suppresses pancreatic cancer growth by modulating tumor immune microenvironment. Marsh JL, etal., Front Biosci (Landmark Ed). 2014 Jan 1;19:113-25.
10. Genomic and protein expression profiling identifies CDK6 as novel independent prognostic marker in medulloblastoma. Mendrzyk F, etal., J Clin Oncol. 2005 Dec 1;23(34):8853-62. doi: 10.1200/JCO.2005.02.8589.
11. A family of human cdc2-related protein kinases. Meyerson M, etal., EMBO J 1992 Aug;11(8):2909-17.
12. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
13. MGDs mouse GO annotations MGD data from the GO Consortium
14. MGD IEA MGD IEA
15. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. Mouse MP Annotation Import Pipeline RGD automated import pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. The Pezcoller lecture: cancer cell cycles revisited. Sherr CJ Cancer Res. 2000 Jul 15;60(14):3689-95.
21. Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death. Tian B, etal., Nat Cell Biol. 2009 Feb;11(2):211-8. doi: 10.1038/ncb1829. Epub 2009 Jan 18.
22. A dual-color FISH gene map of the proximal region of rat Chromosome 4 and comparative analysis in human and mouse. Walentinsson A, etal., Mamm Genome 2001 Dec;12(12):900-8.
23. Therapeutic Delivery of MicroRNA-29b by Cationic Lipoplexes for Lung Cancer. Wu Y, etal., Mol Ther Nucleic Acids. 2013 Apr 16;2:e84. doi: 10.1038/mtna.2013.14.
24. miR-377 inhibited tumorous behaviors of non-small cell lung cancer through directly targeting CDK6. Zhang J, etal., Eur Rev Med Pharmacol Sci. 2016 Nov;20(21):4494-4499.
Additional References at PubMed
PMID:1459009   PMID:7651726   PMID:7739547   PMID:7739548   PMID:8444355   PMID:8822197   PMID:8889548   PMID:9372237   PMID:9438340   PMID:9584157   PMID:9664690   PMID:10349636  
PMID:10384057   PMID:10915795   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11254678   PMID:11544199   PMID:11804782   PMID:12007403   PMID:12196289   PMID:12215429   PMID:12477932  
PMID:12520002   PMID:12592386   PMID:12833137   PMID:12852854   PMID:12861051   PMID:13679319   PMID:14500367   PMID:14610273   PMID:14630948   PMID:14647273   PMID:14724578   PMID:15110774  
PMID:15254224   PMID:15315760   PMID:15315761   PMID:15738651   PMID:15761153   PMID:15782199   PMID:15795936   PMID:16102793   PMID:16141072   PMID:16141073   PMID:16169709   PMID:16413468  
PMID:16602821   PMID:16678773   PMID:16767702   PMID:16869759   PMID:17431401   PMID:17699765   PMID:17700700   PMID:18191580   PMID:18799693   PMID:19040567   PMID:19155308   PMID:19265663  
PMID:19501046   PMID:19667758   PMID:19860623   PMID:19955566   PMID:20100483   PMID:20354191   PMID:20534551   PMID:20609353   PMID:20609517   PMID:21135503   PMID:21224071   PMID:21300982  
PMID:21319271   PMID:21508411   PMID:21628465   PMID:21652635   PMID:21677750   PMID:21873635   PMID:22241836   PMID:22325351   PMID:22465667   PMID:22564414   PMID:22898775   PMID:22922362  
PMID:23079656   PMID:23159226   PMID:23342106   PMID:23622063   PMID:23624920   PMID:23684768   PMID:23803733   PMID:23839966   PMID:23888052   PMID:23918663   PMID:23948297   PMID:24194600  
PMID:24876127   PMID:24929016   PMID:24982181   PMID:25157181   PMID:25342715   PMID:25483078   PMID:25784544   PMID:25986147   PMID:26238476   PMID:26534984   PMID:26707936   PMID:26744331  
PMID:26876175   PMID:27059142   PMID:27099147   PMID:27107080   PMID:27122033   PMID:27141870   PMID:27349859   PMID:27484146   PMID:27653684   PMID:27701148   PMID:27827819   PMID:27915416  
PMID:28067227   PMID:28167794   PMID:28255017   PMID:28923932   PMID:29091030   PMID:29103955   PMID:29275959   PMID:29357734   PMID:29437706   PMID:29523786   PMID:29570951   PMID:29899063  
PMID:30093555   PMID:30635286   PMID:30936836   PMID:32183906   PMID:32325033   PMID:32344427   PMID:32701505   PMID:32703236   PMID:32731332   PMID:32800335   PMID:32855282   PMID:32877917  
PMID:33179102   PMID:33865884   PMID:34062094   PMID:34145036   PMID:34215174   PMID:34248938   PMID:34415667   PMID:34610275   PMID:34746147   PMID:34928956   PMID:34932500   PMID:35064305  
PMID:35831318   PMID:36095192   PMID:36220812   PMID:36907286   PMID:37011871   PMID:37545879   PMID:37611074   PMID:38191655   PMID:38316780  


Genomics

Comparative Map Data
Cdk6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3953,391,004 - 3,581,008 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl53,391,485 - 3,581,008 (+)EnsemblGRCm39 Ensembl
GRCm3853,341,004 - 3,531,008 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl53,341,485 - 3,531,008 (+)EnsemblGRCm38mm10GRCm38
MGSCv3753,344,312 - 3,522,225 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3653,350,318 - 3,528,231 (+)NCBIMGSCv36mm8
Celera53,279,311 - 3,457,786 (+)NCBICelera
Cytogenetic Map5A1NCBI
cM Map52.04NCBI
CDK6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38792,604,921 - 92,836,573 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl792,604,921 - 92,836,573 (-)EnsemblGRCh38hg38GRCh38
GRCh37792,234,235 - 92,465,887 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36792,072,171 - 92,301,148 (-)NCBINCBI36Build 36hg18NCBI36
Build 34791,878,887 - 92,107,863NCBI
Celera786,938,762 - 87,170,471 (-)NCBICelera
Cytogenetic Map7q21.2NCBI
HuRef786,843,599 - 87,075,188 (-)NCBIHuRef
CHM1_1792,164,273 - 92,395,977 (-)NCBICHM1_1
T2T-CHM13v2.0793,846,868 - 94,078,562 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2791,563,451 - 91,795,159 (-)NCBI
Cdk6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8431,592,384 - 31,784,732 (-)NCBIGRCr8
mRatBN7.2430,637,650 - 30,829,688 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl430,646,460 - 30,829,634 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx435,619,211 - 35,799,521 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0431,545,296 - 31,725,618 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0429,941,333 - 30,121,666 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0427,781,728 - 27,969,653 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl427,785,647 - 27,966,398 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0427,685,042 - 27,872,388 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4427,362,656 - 27,618,006 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1427,471,179 - 27,635,330 (-)NCBI
Celera426,070,823 - 26,248,747 (-)NCBICelera
Cytogenetic Map4q13NCBI
Cdk6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554329,521,794 - 9,726,417 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554329,521,794 - 9,727,772 (-)NCBIChiLan1.0ChiLan1.0
CDK6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26110,490,882 - 110,725,552 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17158,755,524 - 158,990,195 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0784,603,419 - 84,835,082 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1798,198,740 - 98,430,305 (-)NCBIpanpan1.1PanPan1.1panPan2
CDK6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11418,178,352 - 18,413,869 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1418,188,429 - 18,419,869 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1417,739,051 - 17,984,302 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01417,990,661 - 18,231,585 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1417,991,832 - 18,228,301 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11418,145,467 - 18,391,128 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01417,862,908 - 18,101,297 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01418,137,407 - 18,377,659 (-)NCBIUU_Cfam_GSD_1.0
Cdk6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511831,562,931 - 31,777,533 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049368031,024,779 - 1,227,516 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049368031,025,047 - 1,229,396 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDK6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl972,518,101 - 72,764,129 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1972,510,858 - 72,765,631 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2979,239,881 - 79,316,977 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CDK6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12156,167,731 - 56,403,976 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2156,170,450 - 56,393,808 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604247,876,694 - 48,113,340 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdk6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624809349,404 - 579,599 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624809349,453 - 588,986 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cdk6
5175 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1552
Count of miRNA genes:558
Interacting mature miRNAs:700
Transcripts:ENSMUST00000042410, ENSMUST00000165117
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141234Pbwg14_mpostnatal body weight growth 14 (mouse)Not determined5121273552Mouse
1301468Eye1_meye weight 1 (mouse)Not determined5121929650Mouse
10412081Bwq13_mbody weight QTL 13 (mouse)Not determined5123606323Mouse
12904958Gmmq8_mgastrocnemius muscle mass QTL 8 (mouse)5129421124Mouse
10401122Pgia41_mproteoglycan induced arthritis 41 (mouse)Not determined582314434823280Mouse
12738412Lfibq4_mliver fibrosis QTL 4 (mouse)5315000020799180Mouse
15039371Nmrs21_mNAFLD-associated magnetic resonance shift 21 (mouse)5350482337504823Mouse

Markers in Region
D5Mit69  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3853,527,185 - 3,527,321UniSTSGRCm38
MGSCv3753,527,185 - 3,527,321UniSTSGRCm37
Celera53,462,746 - 3,462,882UniSTS
Cytogenetic Map5A2-A3UniSTS
cM Map51.0UniSTS
Whitehead Genetic50.0UniSTS
Whitehead_YAC5 UniSTS
Cdk6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3853,520,716 - 3,520,889UniSTSGRCm38
MGSCv3753,520,716 - 3,520,889UniSTSGRCm37
Celera53,456,277 - 3,456,450UniSTS
Cytogenetic Map5A2-A3UniSTS
cM Map5 UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_009873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030254091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC026478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC090432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC090443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF132482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF132483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK030810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK050987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK078973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK209962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC027662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC119360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC120595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ176468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X65068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000042410   ⟹   ENSMUSP00000037925
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl53,394,312 - 3,572,225 (+)Ensembl
GRCm38.p6 Ensembl53,344,312 - 3,522,225 (+)Ensembl
RefSeq Acc Id: ENSMUST00000165117   ⟹   ENSMUSP00000126024
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl53,393,893 - 3,581,008 (+)Ensembl
GRCm38.p6 Ensembl53,343,893 - 3,531,008 (+)Ensembl
RefSeq Acc Id: ENSMUST00000197385   ⟹   ENSMUSP00000143492
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl53,393,916 - 3,440,693 (+)Ensembl
GRCm38.p6 Ensembl53,343,916 - 3,390,693 (+)Ensembl
RefSeq Acc Id: ENSMUST00000197607   ⟹   ENSMUSP00000142796
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl53,393,732 - 3,394,437 (+)Ensembl
GRCm38.p6 Ensembl53,343,732 - 3,344,437 (+)Ensembl
RefSeq Acc Id: ENSMUST00000199156   ⟹   ENSMUSP00000143564
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl53,391,485 - 3,394,453 (+)Ensembl
GRCm38.p6 Ensembl53,341,485 - 3,344,453 (+)Ensembl
RefSeq Acc Id: ENSMUST00000199396
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl53,520,949 - 3,523,180 (+)Ensembl
GRCm38.p6 Ensembl53,470,949 - 3,473,180 (+)Ensembl
RefSeq Acc Id: NM_009873   ⟹   NP_034003
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3953,393,893 - 3,581,008 (+)NCBI
GRCm3853,343,893 - 3,531,008 (+)NCBI
MGSCv3753,344,312 - 3,522,225 (+)RGD
Celera53,279,311 - 3,457,786 (+)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030254091   ⟹   XP_030109951
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3953,391,004 - 3,581,008 (+)NCBI
GRCm3853,341,004 - 3,531,008 (+)NCBI
Sequence:
RefSeq Acc Id: NP_034003   ⟸   NM_009873
- UniProtKB: Q9R1D2 (UniProtKB/Swiss-Prot),   Q9R1D3 (UniProtKB/Swiss-Prot),   Q64261 (UniProtKB/Swiss-Prot),   Q0VBK8 (UniProtKB/TrEMBL),   Q3U4J9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030109951   ⟸   XM_030254091
- Peptide Label: isoform X1
- UniProtKB: Q9R1D2 (UniProtKB/Swiss-Prot),   Q64261 (UniProtKB/Swiss-Prot),   Q9R1D3 (UniProtKB/Swiss-Prot),   Q0VBK8 (UniProtKB/TrEMBL),   Q3U4J9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000143492   ⟸   ENSMUST00000197385
RefSeq Acc Id: ENSMUSP00000142796   ⟸   ENSMUST00000197607
RefSeq Acc Id: ENSMUSP00000126024   ⟸   ENSMUST00000165117
RefSeq Acc Id: ENSMUSP00000143564   ⟸   ENSMUST00000199156
RefSeq Acc Id: ENSMUSP00000037925   ⟸   ENSMUST00000042410
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64261-F1-model_v2 AlphaFold Q64261 1-326 view protein structure

Promoters
RGD ID:6847891
Promoter ID:MM_ACW:36869
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:CDK6.DSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3653,341,296 - 3,341,796 (+)MPROMDB
RGD ID:6837239
Promoter ID:MM_KWN:41247
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell
Transcripts:UC008WGU.1,   UC008WGV.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3653,342,961 - 3,344,472 (+)MPROMDB
RGD ID:6885894
Promoter ID:EPDNEW_M6397
Type:initiation region
Name:Cdk6_1
Description:Mus musculus cyclin-dependent kinase 6 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3853,343,918 - 3,343,978EPDNEW
RGD ID:6837045
Promoter ID:MM_KWN:41248
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour
Transcripts:UC008WGW.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3653,521,721 - 3,522,221 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1277162 AgrOrtholog
Ensembl Genes ENSMUSG00000040274 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000042410.5 UniProtKB/Swiss-Prot
  ENSMUST00000165117 ENTREZGENE
  ENSMUST00000165117.8 UniProtKB/Swiss-Prot
  ENSMUST00000197385.2 UniProtKB/TrEMBL
  ENSMUST00000197607.2 UniProtKB/TrEMBL
  ENSMUST00000199156.2 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CDK6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12571 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1277162 ENTREZGENE
NCBI Gene 12571 ENTREZGENE
PANTHER CELL DIVISION PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYCLIN-DEPENDENT KINASE 6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cdk6 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JEJ6_MOUSE UniProtKB/TrEMBL
  A0A0G2JGA8_MOUSE UniProtKB/TrEMBL
  A0A0G2JGH2_MOUSE UniProtKB/TrEMBL
  CDK6_MOUSE UniProtKB/Swiss-Prot
  Q0VBK8 ENTREZGENE, UniProtKB/TrEMBL
  Q3U4J9 ENTREZGENE, UniProtKB/TrEMBL
  Q64261 ENTREZGENE
  Q9R1D2 ENTREZGENE
  Q9R1D3 ENTREZGENE
UniProt Secondary Q9R1D2 UniProtKB/Swiss-Prot
  Q9R1D3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-05-02 Cdk6  cyclin dependent kinase 6  Cdk6  cyclin-dependent kinase 6  Symbol and/or name change 5135510 APPROVED