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Gene: CXCR2 (C-X-C motif chemokine receptor 2) Homo sapiens

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Symbol:

CXCR2

Name:

C-X-C motif chemokine receptor 2

RGD ID:

735299

HGNC Page

HGNC:6027

Description:

Enables interleukin-8 binding activity and interleukin-8 receptor activity. Involved in several processes, including cellular defense response; interleukin-8-mediated signaling pathway; and neutrophil chemotaxis. Located in several cellular components, including cell surface; mast cell granule; and mitotic spindle. Implicated in IgA glomerulonephritis; WHIM syndrome 2; acute pyelonephritis; end stage renal disease; and urinary bladder cancer. Biomarker of chronic obstructive pulmonary disease; nephroblastoma; and systemic lupus erythematosus.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

C-X-C chemokine receptor type 2; CD182; CDw128b; chemokine (C-X-C motif) receptor 2; chemokine (CXC) receptor 2; CMKAR2; CXC-R2; CXCR-2; CXCR2 gene for IL8 receptor type B; GRO/MGSA receptor; high affinity interleukin-8 receptor B; IL-8 receptor type 2; IL-8R B; IL8R2; IL8RA; IL8RB; interleukin 8 receptor B; interleukin 8 receptor type 2; interleukin 8 receptor, beta; interleukin-8 receptor type B; WHIMS2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Related Pseudogenes:

CXCR2P1

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	218,125,294 - 218,137,251 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	218,125,289 - 218,137,251 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	218,990,017 - 219,001,974 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	218,698,991 - 218,710,220 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	218,816,251 - 218,827,481	NCBI
Celera	2	212,756,449 - 212,768,411 (+)	NCBI		Celera
Cytogenetic Map	2	q35	NCBI
HuRef	2	210,842,767 - 210,854,732 (+)	NCBI		HuRef
CHM1_1	2	218,996,503 - 219,008,469 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	218,610,987 - 218,622,946 (+)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Lung Injury (ISO)

acute pyelonephritis (IAGP)

alacrima, achalasia, and impaired intellectual development syndrome (IAGP)

allergic disease (EXP)

brain disease (EXP)

bronchopneumonia (ISO)

chronic obstructive pulmonary disease (IEP)

colitis (ISO)

common cold (ISO)

COVID-19 (HEP)

cystic fibrosis (ISO)

demyelinating disease (ISO)

dengue disease (ISO)

Diabetic Nephropathies (ISO)

end stage renal disease (IAGP)

Experimental Autoimmune Encephalomyelitis (ISO)

Hyperalgesia (ISO)

hypertension (EXP)

IgA glomerulonephritis (IAGP)

Inflammation (ISO)

juvenile rheumatoid arthritis (EXP)

Kidney Reperfusion Injury (ISO)

Legionnaires' disease (ISO)

liver disease (EXP)

lung disease (ISO)

Lung Injury (ISO)

Lyme disease (ISO)

mastitis (EXP)

middle cerebral artery infarction (EXP)

nephritis (ISO)

nephroblastoma (IEP)

Neuralgia (EXP)

Neurodevelopmental Disorders (IAGP)

paroxysmal nonkinesigenic dyskinesia 1 (IAGP)

periapical periodontitis (ISO)

pneumonia (EXP)

pulmonary fibrosis (ISO)

pyelonephritis (ISO)

renal cell carcinoma (ISO)

Sepsis (EXP)

systemic lupus erythematosus (IEP)

Transplant Rejection (ISO)

ulcerative colitis (EXP)

urinary bladder cancer (IAGP)

urinary tract infection (ISO)

Vascular Remodeling (EXP)

WHIM syndrome 2 (IAGP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-nicotine (EXP)

1-chloro-2,4-dinitrobenzene (ISO)

1-nitropyrene (EXP)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,6-trinitrobenzenesulfonic acid (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2-naphthylamine (EXP)

3,4-methylenedioxymethamphetamine (ISO)

aflatoxin B1 (EXP)

all-trans-retinoic acid (EXP)

aminoguanidine (ISO)

ammonium chloride (ISO)

antirheumatic drug (EXP)

arsenous acid (EXP)

asperentin (ISO)

atrazine (EXP)

Azoxymethane (ISO)

benzamide (ISO)

benzo[a]pyrene (EXP,ISO)

benzo[b]fluoranthene (ISO)

Benzo[k]fluoranthene (ISO)

bis(2-chloroethyl) sulfide (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (ISO)

Brevianamide A (ISO)

calcium atom (EXP,ISO)

calcium(0) (EXP,ISO)

carbon nanotube (ISO)

celecoxib (ISO)

ceric oxide (ISO)

CGP 52608 (EXP)

cisplatin (EXP)

clodronic acid (ISO)

copper atom (ISO)

copper(0) (ISO)

cordycepin (ISO)

curcumin (EXP)

cytochalasin D (EXP)

Deoxycorticosterone acetate (ISO)

deoxynivalenol (ISO)

dextran sulfate (ISO)

diarsenic trioxide (EXP)

Dibutyl phosphate (EXP)

dichloroacetic acid (EXP)

dichloromethane (ISO)

dioxygen (ISO)

diphenyl diselenide (ISO)

doramapimod (EXP)

dorsomorphin (EXP)

ethyl methanesulfonate (EXP)

ethylbenzene (ISO)

excitatory amino acid agonist (ISO)

fenvalerate (ISO)

formaldehyde (EXP)

furan (ISO)

iron(2+) sulfate (anhydrous) (EXP)

isoprenaline (ISO)

lipoarabinomannan (EXP)

lipopolysaccharide (EXP,ISO)

lipoteichoic acid (EXP)

mechlorethamine (ISO)

methacholine chloride (ISO)

methotrexate (EXP)

methyl methanesulfonate (EXP)

Monobutylphthalate (ISO)

mycophenolic acid (ISO)

mycotoxin (ISO)

nickel atom (EXP)

Nicotinamide N-oxide (EXP)

nicotine (EXP)

oleandrin (EXP)

oxaliplatin (ISO)

ozone (EXP,ISO)

p-chloromercuribenzoic acid (EXP)

paracetamol (ISO)

pentachlorophenol (EXP)

phenobarbital (ISO)

phorbol 13-acetate 12-myristate (EXP)

potassium dichromate (ISO)

prednisolone (EXP)

reparixin (EXP,ISO)

S-(1,2-dichlorovinyl)-L-cysteine (EXP)

SB 203580 (EXP)

SB 431542 (EXP)

silicon dioxide (EXP,ISO)

simvastatin (ISO)

sodium arsenite (EXP)

sodium chloride (ISO)

testosterone (ISO)

tetrachloromethane (ISO)

thalidomide (EXP)

thioacetamide (ISO)

titanium dioxide (ISO)

TMC-120A (ISO)

topotecan (ISO)

tributylstannane (ISO)

trichloroethene (ISO)

triclosan (EXP)

triphenyl phosphate (EXP)

tungsten (ISO)

vinclozolin (ISO)

wortmannin (EXP)

XL147 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acute inflammatory response to antigenic stimulus (IEA,ISO)

calcium-mediated signaling (IBA)

cell surface receptor signaling pathway (IDA)

cellular defense response (IDA)

chemokine-mediated signaling pathway (IEA)

chemotaxis (IDA,IEA)

dendritic cell chemotaxis (TAS)

G protein-coupled receptor signaling pathway (IEA)

immune response (IBA)

inflammatory response (TAS)

interleukin-8-mediated signaling pathway (IDA)

metanephric tubule morphogenesis (IEA,ISO)

midbrain development (IEA,ISO)

negative regulation of apoptotic process (IEA,ISO)

negative regulation of neutrophil apoptotic process (IEA,ISO)

neutrophil activation (IDA)

neutrophil chemotaxis (IBA,IDA,IEA,ISO)

phospholipase C-activating G protein-coupled receptor signaling pathway (IDA)

positive regulation of angiogenesis (IEA,ISO)

positive regulation of cardiac muscle cell apoptotic process (IEA,ISO)

positive regulation of cell population proliferation (IDA)

positive regulation of cytosolic calcium ion concentration (IBA,IEA,ISO)

positive regulation of leukocyte chemotaxis (IEA,ISO)

positive regulation of neutrophil chemotaxis (IEA,ISO)

positive regulation of vascular permeability (IEA,ISO)

receptor internalization (IDA)

signal transduction (TAS)

Cellular Component

cell surface (IDA)

external side of plasma membrane (IBA)

mast cell granule (IDA)

membrane (IDA,IEA)

microtubule cytoskeleton (IDA)

mitotic spindle (IDA)

nucleoplasm (IDA)

plasma membrane (IDA,IEA,TAS)

secretory granule membrane (TAS)

Molecular Function

C-C chemokine binding (IBA)

C-C chemokine receptor activity (IBA)

C-X-C chemokine receptor activity (IDA,IEA)

chemokine receptor activity (IEA)

G protein-coupled receptor activity (IDA,IEA)

interleukin-8 binding (IEA,IPI)

interleukin-8 receptor activity (IDA)

protein binding (IPI)

Molecular Pathway Annotations Click to see Annotation Detail View

endocytosis pathway (IEA)

Phenotype Annotations Click to see Annotation Detail View

Human Phenotype

Autosomal recessive inheritance (IAGP)

Bacteriuria (IAGP)

Childhood onset (IAGP)

Chronic neutropenia (IAGP)

Elevated circulating C-reactive protein concentration (IAGP)

Elevated erythrocyte sedimentation rate (IAGP)

Fever (IAGP)

Myelokathexis (IAGP)

Pyuria (IAGP)

Recurrent gingivitis (IAGP)

Severe infection (IAGP)

Tetralogy of Fallot (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Contrasting roles for CXCR2 during experimental colitis.	Ajuebor MN, etal., Exp Mol Pathol. 2004 Feb;76(1):1-8.
2.	Bladder cancer SNP panel predicts susceptibility and survival.	Andrew AS, etal., Hum Genet. 2009 Jun;125(5-6):527-39. Epub 2009 Mar 1.
3.	Treatment with antileukinate, a CXCR2 chemokine receptor antagonist, protects mice against acute pancreatitis and associated lung injury.	Bhatia M and Hegde A, Regul Pept. 2007 Jan 10;138(1):40-8. Epub 2006 Oct 2.
4.	Susceptibility to experimental Lyme arthritis correlates with KC and monocyte chemoattractant protein-1 production in joints and requires neutrophil recruitment via CXCR2.	Brown CR, etal., J Immunol. 2003 Jul 15;171(2):893-901.
5.	Inhibition of the chemokine receptor CXCR2 prevents kidney graft function deterioration due to ischemia/reperfusion.	Cugini D, etal., Kidney Int. 2005 May;67(5):1753-61.
6.	Chemokine receptor CXCR2 mediates bacterial clearance rather than neutrophil recruitment in a murine model of pneumonic plague.	Eisele NA, etal., Am J Pathol. 2011 Mar;178(3):1190-200.
7.	Abnormal expression of chemokine receptors on T-cells from patients with systemic lupus erythematosus.	Eriksson C, etal., Lupus. 2003;12(10):766-74.
8.	Suppression of liver regeneration affects hepatic graft survival in small-for-size liver transplantation in rats.	Fu WY, etal., Hepatol Res. 2013 Mar;43(3):300-10. doi: 10.1111/j.1872-034X.2012.01071.x. Epub 2012 Aug 6.
9.	GOAs Human GO annotations	GOA_HUMAN data from the GO Consortium
10.	Mechanism of neutrophil recruitment to the lung after pulmonary contusion.	Hoth JJ, etal., Shock. 2011 Jun;35(6):604-9.
11.	Genetic variations of interleukin-8, CXCR1 and CXCR2 genes and risk of acute pyelonephritis in children.	Javor J, etal., Int J Immunogenet. 2012 Aug;39(4):338-45. doi: 10.1111/j.1744-313X.2012.01096.x. Epub 2012 Feb 10.
12.	Purple corn anthocyanins inhibit diabetes-associated glomerular monocyte activation and macrophage infiltration.	Kang MK, etal., Am J Physiol Renal Physiol. 2012 Oct;303(7):F1060-9. doi: 10.1152/ajprenal.00106.2012. Epub 2012 Jul 11.
13.	Inhibition of CXCR2 signaling promotes recovery in models of multiple sclerosis.	Kerstetter AE, etal., Exp Neurol. 2009 Nov;220(1):44-56. doi: 10.1016/j.expneurol.2009.07.010. Epub 2009 Jul 17.
14.	ELR+-CXC chemokines and their receptors in early metanephric development.	Levashova ZB, etal., J Am Soc Nephrol. 2007 Aug;18(8):2359-70. Epub 2007 Jul 18.
15.	IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury.	Li L, etal., J Clin Invest. 2010 Jan;120(1):331-42. doi: 10.1172/JCI38702. Epub 2009 Dec 14.
16.	CXCR2 mediates NADPH oxidase-independent neutrophil extracellular trap formation in cystic fibrosis airway inflammation.	Marcos V, etal., Nat Med. 2010 Sep;16(9):1018-23. Epub 2010 Sep 5.
17.	Mechanisms underlying the nociceptive responses induced by platelet-activating factor (PAF) in the rat paw.	Marotta DM, etal., Biochem Pharmacol. 2009 Apr 1;77(7):1223-35.
18.	Interleukin-33 contributes to disease severity in Dengue virus infection in mice.	Marques RE, etal., Immunology. 2018 Dec;155(4):477-490. doi: 10.1111/imm.12988. Epub 2018 Sep 10.
19.	Endogenous thrombospondin-1 regulates leukocyte recruitment and activation and accelerates death from systemic candidiasis.	Martin-Manso G, etal., PLoS One. 2012;7(11):e48775. doi: 10.1371/journal.pone.0048775. Epub 2012 Nov 7.
20.	The role of CXCR2/CXCR2 ligand biological axis in renal cell carcinoma.	Mestas J, etal., J Immunol. 2005 Oct 15;175(8):5351-7.
21.	CXCR2 is required for neutrophilic airway inflammation and hyperresponsiveness in a mouse model of human rhinovirus infection.	Nagarkar DR, etal., J Immunol. 2009 Nov 15;183(10):6698-707. Epub 2009 Oct 28.
22.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
23.	Biopsy neutrophilia, neutrophil chemokine and receptor gene expression in severe exacerbations of chronic obstructive pulmonary disease.	Qiu Y, etal., Am J Respir Crit Care Med. 2003 Oct 15;168(8):968-75. Epub 2003 Jul 11.
24.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
25.	A rat model of picornavirus-induced airway infection and inflammation.	Rosenthal LA, etal., Virol J. 2009 Aug 11;6:122.
26.	Role of the chemokine receptor CXCR2 in bleomycin-induced pulmonary inflammation and fibrosis.	Russo RC, etal., Am J Respir Cell Mol Biol. 2009 Apr;40(4):410-21. Epub 2008 Oct 3.
27.	Association of chemokine gene variants with end stage renal disease in North Indian population.	Singh V, etal., Transpl Immunol. 2013 Jun;28(4):189-92. doi: 10.1016/j.trim.2013.04.004. Epub 2013 Apr 21.
28.	Characterization of cigarette smoke-induced inflammatory and mucus hypersecretory changes in rat lung and the role of CXCR2 ligands in mediating this effect.	Stevenson CS, etal., Am J Physiol Lung Cell Mol Physiol. 2005 Mar;288(3):L514-22. Epub 2004 Oct 29.
29.	Polymorphisms of CXCL8 and Its Receptor CXCR2 Contribute to the Development and Progression of Childhood IgA Nephropathy.	Suh JS, etal., J Interferon Cytokine Res. 2011 Jan 8.
30.	Effects of epithelial and neutrophil CXCR2 on innate immunity and resistance to kidney infection.	Svensson M, etal., Kidney Int. 2008 Jul;74(1):81-90. doi: 10.1038/ki.2008.105. Epub 2008 Apr 9.
31.	Acute pyelonephritis and renal scarring are caused by dysfunctional innate immunity in mCxcr2 heterozygous mice.	Svensson M, etal., Kidney Int. 2011 Nov;80(10):1064-72. doi: 10.1038/ki.2011.257. Epub 2011 Aug 3.
32.	Chemokine-dependent neutrophil recruitment in a murine model of Legionella pneumonia: potential role of neutrophils as immunoregulatory cells.	Tateda K, etal., Infect Immun. 2001 Apr;69(4):2017-24.
33.	Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients.	Xiong Y, etal., Emerg Microbes Infect. 2020 Dec;9(1):761-770. doi: 10.1080/22221751.2020.1747363.
34.	Expression of angiogenic factors in rat periapical lesions.	Yamanaka Y, etal., J Endod. 2012 Mar;38(3):313-7. doi: 10.1016/j.joen.2011.11.009. Epub 2011 Dec 23.
35.	Opposing effects of 60% oxygen and neutrophil influx on alveologenesis in the neonatal rat.	Yi M, etal., Am J Respir Crit Care Med. 2004 Dec 1;170(11):1188-96. Epub 2004 Sep 3.
36.	Combinatorial model of chemokine involvement in glomerular monocyte recruitment: role of CXC chemokine receptor 2 in infiltration during nephrotoxic nephritis.	Zernecke A, etal., J Immunol. 2001 May 1;166(9):5755-62.
37.	Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients.	Zhou Z, etal., Cell Host Microbe. 2020 Jun 10;27(6):883-890.e2. doi: 10.1016/j.chom.2020.04.017. Epub 2020 May 4.

Additional References at PubMed

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PMID:32694731	PMID:32800946	PMID:32867211	PMID:32910411	PMID:33000506	PMID:33231340	PMID:33347356	PMID:33424860	PMID:33517283	PMID:33583159	PMID:33755965	PMID:33788733
PMID:33807899	PMID:33835690	PMID:34025668	PMID:34038868	PMID:34050991	PMID:34115261	PMID:34238119	PMID:34692853	PMID:34730557	PMID:34831316	PMID:34840630	PMID:34854278
PMID:34911941	PMID:34999169	PMID:35181615	PMID:35212311	PMID:35216283	PMID:35377900	PMID:35768823	PMID:35795659	PMID:35920183	PMID:35963638	PMID:36086981	PMID:36349481
PMID:36577281	PMID:36613703	PMID:36622345	PMID:37154009	PMID:37331296	PMID:37403022	PMID:37508478	PMID:37688444	PMID:37907543	PMID:38281854	PMID:38407596	PMID:38426279
PMID:38528533	PMID:38627393	PMID:38715171	PMID:38724465	PMID:39244903

Genomics

Comparative Map Data

CXCR2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	218,125,294 - 218,137,251 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	218,125,289 - 218,137,251 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	218,990,017 - 219,001,974 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	218,698,991 - 218,710,220 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	218,816,251 - 218,827,481	NCBI
Celera	2	212,756,449 - 212,768,411 (+)	NCBI		Celera
Cytogenetic Map	2	q35	NCBI
HuRef	2	210,842,767 - 210,854,732 (+)	NCBI		HuRef
CHM1_1	2	218,996,503 - 219,008,469 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	218,610,987 - 218,622,946 (+)	NCBI		T2T-CHM13v2.0

Cxcr2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	74,193,153 - 74,200,405 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	74,193,150 - 74,200,405 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	74,153,994 - 74,161,246 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	74,153,989 - 74,161,246 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	74,200,568 - 74,207,820 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	74,087,201 - 74,094,453 (+)	NCBI		MGSCv36	mm8
Celera	1	74,715,354 - 74,722,423 (+)	NCBI		Celera
Cytogenetic Map	1	C3	NCBI
cM Map	1	38.41	NCBI

Cxcr2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	83,178,645 - 83,185,017 (+)	NCBI		GRCr8
mRatBN7.2	9	75,729,493 - 75,735,868 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	75,729,115 - 75,739,425 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	84,182,990 - 84,189,368 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	89,311,908 - 89,318,286 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	87,698,116 - 87,704,494 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	81,427,275 - 81,435,065 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	81,427,730 - 81,434,102 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	81,193,442 - 81,199,814 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	73,470,943 - 73,477,315 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	73,617,924 - 73,624,297 (+)	NCBI
Celera	9	73,306,852 - 73,313,224 (+)	NCBI		Celera
Cytogenetic Map	9	q33	NCBI

CXCR2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	120,761,870 - 120,773,382 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	120,776,837 - 120,788,349 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	105,387,198 - 105,400,533 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	223,987,556 - 223,999,511 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	223,997,066 - 223,998,148 (+)	Ensembl	panpan1.1		panPan2

CXCR2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	37	24,831,351 - 24,846,387 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	37	24,843,171 - 24,844,247 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	37	25,659,341 - 25,664,768 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	37	24,847,511 - 24,862,398 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	37	24,855,136 - 24,860,563 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	37	24,760,631 - 24,766,058 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	37	24,694,995 - 24,700,420 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	37	24,714,358 - 24,719,785 (+)	NCBI		UU_Cfam_GSD_1.0

CXCR2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	15	120,219,657 - 120,230,203 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	133,275,203 - 133,286,266 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LOC103217855
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	104,012,906 - 104,025,599 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	104,022,811 - 104,023,893 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	95,376,101 - 95,386,709 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in CXCR2
198 total Variants

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 2q32.3-37.3(chr2:194898783-236473913)x3	copy number gain	See cases [RCV000051119]	Chr2:194898783..236473913 [GRCh38] Chr2:195763507..237382556 [GRCh37] Chr2:195471752..237047295 [NCBI36] Chr2:2q32.3-37.3	pathogenic
GRCh38/hg38 2q32.2-37.3(chr2:188818195-242065208)x3	copy number gain	See cases [RCV000052958]	Chr2:188818195..242065208 [GRCh38] Chr2:189682921..243007359 [GRCh37] Chr2:189391166..242656032 [NCBI36] Chr2:2q32.2-37.3	pathogenic
GRCh38/hg38 2q32.2-37.3(chr2:190310736-241892770)x3	copy number gain	See cases [RCV000052959]	Chr2:190310736..241892770 [GRCh38] Chr2:191175462..242834921 [GRCh37] Chr2:190883707..242483594 [NCBI36] Chr2:2q32.2-37.3	pathogenic
GRCh38/hg38 2q32.3-37.3(chr2:193122313-241074980)x3	copy number gain	Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052960]\|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052960]\|See cases [RCV000052960]	Chr2:193122313..241074980 [GRCh38] Chr2:193987039..242014395 [GRCh37] Chr2:193695284..241663068 [NCBI36] Chr2:2q32.3-37.3	pathogenic
GRCh38/hg38 2q34-36.3(chr2:212614422-227121230)x3	copy number gain	Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052964]\|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052964]\|See cases [RCV000052964]	Chr2:212614422..227121230 [GRCh38] Chr2:213479146..227985946 [GRCh37] Chr2:213187391..227694190 [NCBI36] Chr2:2q34-36.3	pathogenic
GRCh38/hg38 2q34-37.3(chr2:210579676-242126245)x3	copy number gain	See cases [RCV000135934]	Chr2:210579676..242126245 [GRCh38] Chr2:211444400..243059659 [GRCh37] Chr2:211152645..242717069 [NCBI36] Chr2:2q34-37.3	pathogenic
GRCh38/hg38 2q31.3-36.2(chr2:180513793-224302848)x3	copy number gain	See cases [RCV000139446]	Chr2:180513793..224302848 [GRCh38] Chr2:181378520..225167565 [GRCh37] Chr2:181086765..224875809 [NCBI36] Chr2:2q31.3-36.2	pathogenic
GRCh38/hg38 2q32.2-37.3(chr2:189436149-241841232)x3	copy number gain	See cases [RCV000142307]	Chr2:189436149..241841232 [GRCh38] Chr2:190300875..242783384 [GRCh37] Chr2:190009120..242432057 [NCBI36] Chr2:2q32.2-37.3	pathogenic
GRCh38/hg38 2q35-37.3(chr2:218101759-242126245)x3	copy number gain	See cases [RCV000143216]	Chr2:218101759..242126245 [GRCh38] Chr2:218966482..243059659 [GRCh37] Chr2:218674727..242717069 [NCBI36] Chr2:2q35-37.3	pathogenic
NM_001557.4(CXCR2):c.235G>A (p.Gly79Ser)	single nucleotide variant	not provided [RCV000903661]\|not specified [RCV000239194]	Chr2:218135036 [GRCh38] Chr2:218999759 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.1015T>A (p.Ser339Thr)	single nucleotide variant	not specified [RCV004299654]	Chr2:218135816 [GRCh38] Chr2:219000539 [GRCh37] Chr2:2q35	uncertain significance
GRCh37/hg19 2q35-36.3(chr2:217374144-227643620)x1	copy number loss	not provided [RCV000585275]	Chr2:217374144..227643620 [GRCh37] Chr2:2q35-36.3	likely pathogenic
GRCh37/hg19 2q35(chr2:218647714-219053933)	copy number gain	Abnormal esophagus morphology [RCV000416700]	Chr2:218647714..219053933 [GRCh37] Chr2:2q35	uncertain significance
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)	copy number gain	See cases [RCV000512056]	Chr2:12771..242783384 [GRCh37] Chr2:2p25.3-q37.3	pathogenic
GRCh37/hg19 2q34-37.3(chr2:213518431-242783384)x3	copy number gain	See cases [RCV000512009]	Chr2:213518431..242783384 [GRCh37] Chr2:2q34-37.3	pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3	copy number gain	See cases [RCV000511212]	Chr2:12771..242783384 [GRCh37] Chr2:2p25.3-q37.3	pathogenic
NM_001557.4(CXCR2):c.386A>G (p.Asn129Ser)	single nucleotide variant	not specified [RCV004299341]	Chr2:218135187 [GRCh38] Chr2:218999910 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.707G>A (p.Arg236His)	single nucleotide variant	not provided [RCV000658899]	Chr2:218135508 [GRCh38] Chr2:219000231 [GRCh37] Chr2:2q35	uncertain significance
GRCh37/hg19 2q35-36.3(chr2:218813434-227450699)x1	copy number loss	not provided [RCV000682163]	Chr2:218813434..227450699 [GRCh37] Chr2:2q35-36.3	pathogenic
GRCh37/hg19 2q33.3-35(chr2:205169148-219149293)x3	copy number gain	not provided [RCV000682166]	Chr2:205169148..219149293 [GRCh37] Chr2:2q33.3-35	pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3	copy number gain	not provided [RCV000752802]	Chr2:14238..243048760 [GRCh37] Chr2:2p25.3-q37.3	pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3	copy number gain	not provided [RCV000752804]	Chr2:15672..243101834 [GRCh37] Chr2:2p25.3-q37.3	pathogenic
NM_001557.4(CXCR2):c.472A>T (p.Lys158Ter)	single nucleotide variant	not provided [RCV000997660]	Chr2:218135273 [GRCh38] Chr2:218999996 [GRCh37] Chr2:2q35	likely pathogenic
NM_001557.4(CXCR2):c.476G>T (p.Arg159Leu)	single nucleotide variant	not provided [RCV000997661]	Chr2:218135277 [GRCh38] Chr2:219000000 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.87G>T (p.Leu29=)	single nucleotide variant	CXCR2-related disorder [RCV003933142]\|not provided [RCV000926498]	Chr2:218134888 [GRCh38] Chr2:218999611 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.663C>T (p.Ile221=)	single nucleotide variant	not provided [RCV000902864]	Chr2:218135464 [GRCh38] Chr2:219000187 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.1041C>T (p.Ser347=)	single nucleotide variant	not provided [RCV000946677]	Chr2:218135842 [GRCh38] Chr2:219000565 [GRCh37] Chr2:2q35	benign
GRCh37/hg19 2q35(chr2:218271898-219825640)	copy number gain	not provided [RCV000767784]	Chr2:218271898..219825640 [GRCh37] Chr2:2q35	likely pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:1-243199373)	copy number gain	Mosaic trisomy 2 [RCV002280628]	Chr2:1..243199373 [GRCh37] Chr2:2p25.3-q37.3	pathogenic
NM_001557.4(CXCR2):c.669A>G (p.Pro223=)	single nucleotide variant	not provided [RCV000960127]	Chr2:218135470 [GRCh38] Chr2:219000193 [GRCh37] Chr2:2q35	benign
NM_001557.4(CXCR2):c.488A>T (p.Lys163Ile)	single nucleotide variant	not provided [RCV000997662]	Chr2:218135289 [GRCh38] Chr2:219000012 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.458G>A (p.Arg153His)	single nucleotide variant	CXCR2-related disorder [RCV003396582]\|not provided [RCV000997659]	Chr2:218135259 [GRCh38] Chr2:218135259..218135260 [GRCh38] Chr2:218999982 [GRCh37] Chr2:218999982..218999983 [GRCh37] Chr2:2q35	likely benign\|conflicting interpretations of pathogenicity\|uncertain significance
Single allele	duplication	Neurodevelopmental disorder [RCV000787403]	Chr2:188926928..225298653 [GRCh37] Chr2:2q32.1-36.2	pathogenic
GRCh37/hg19 2q34-37.3(chr2:210779657-239879183)x3	copy number gain	See cases [RCV000790568]	Chr2:210779657..239879183 [GRCh37] Chr2:2q34-37.3	pathogenic
NM_001557.4(CXCR2):c.721G>A (p.Ala241Thr)	single nucleotide variant	not provided [RCV000892609]	Chr2:218135522 [GRCh38] Chr2:219000245 [GRCh37] Chr2:2q35	benign
NM_001557.4(CXCR2):c.1075A>T (p.Thr359Ser)	single nucleotide variant	not provided [RCV000997663]	Chr2:218135876 [GRCh38] Chr2:219000599 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.968del (p.His323fs)	deletion	WHIM syndrome 2 [RCV001532874]	Chr2:218135769 [GRCh38] Chr2:219000492 [GRCh37] Chr2:2q35	pathogenic
NM_001557.4(CXCR2):c.90C>T (p.Pro30=)	single nucleotide variant	not provided [RCV000909356]	Chr2:218134891 [GRCh38] Chr2:218999614 [GRCh37] Chr2:2q35	benign
GRCh37/hg19 2q35(chr2:216883237-220953003)x3	copy number gain	not provided [RCV001007510]	Chr2:216883237..220953003 [GRCh37] Chr2:2q35	pathogenic
NM_001557.4(CXCR2):c.*127T>C	single nucleotide variant	not provided [RCV001599075]	Chr2:218136011 [GRCh38] Chr2:219000734 [GRCh37] Chr2:2q35	benign
GRCh37/hg19 2q34-35(chr2:215122019-220397907)x1	copy number loss	not provided [RCV001259180]	Chr2:215122019..220397907 [GRCh37] Chr2:2q34-35	likely pathogenic
NM_001557.4(CXCR2):c.550C>T (p.Arg184Ter)	single nucleotide variant	not provided [RCV001907929]	Chr2:218135351 [GRCh38] Chr2:219000074 [GRCh37] Chr2:2q35	pathogenic\|uncertain significance
GRCh37/hg19 2q31.2-37.3(chr2:178397959-243007457)x3	copy number gain	See cases [RCV001263052]	Chr2:178397959..243007457 [GRCh37] Chr2:2q31.2-37.3	pathogenic
NM_001557.4(CXCR2):c.119A>G (p.Glu40Gly)	single nucleotide variant	not provided [RCV001371695]	Chr2:218134920 [GRCh38] Chr2:218999643 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.711G>A (p.Thr237=)	single nucleotide variant	not provided [RCV001413527]	Chr2:218135512 [GRCh38] Chr2:219000235 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.743G>A (p.Arg248Gln)	single nucleotide variant	CXCR2-related disorder [RCV003956017]\|not provided [RCV001464864]	Chr2:218135544 [GRCh38] Chr2:218135544..218135545 [GRCh38] Chr2:219000267 [GRCh37] Chr2:219000267..219000268 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.-25-245G>A	single nucleotide variant	not provided [RCV001538348]	Chr2:218134532 [GRCh38] Chr2:218999255 [GRCh37] Chr2:2q35	benign
NM_001557.4(CXCR2):c.274T>C (p.Leu92=)	single nucleotide variant	not provided [RCV001475729]	Chr2:218135075 [GRCh38] Chr2:218999798 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.706C>T (p.Arg236Cys)	single nucleotide variant	CXCR2-related disorder [RCV003956020]\|not provided [RCV001466244]	Chr2:218135507 [GRCh38] Chr2:218135507..218135508 [GRCh38] Chr2:219000230 [GRCh37] Chr2:219000230..219000231 [GRCh37] Chr2:2q35	likely benign\|conflicting interpretations of pathogenicity
NM_001557.4(CXCR2):c.751C>A (p.Arg251=)	single nucleotide variant	not provided [RCV001397977]	Chr2:218135552 [GRCh38] Chr2:219000275 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.756C>T (p.Val252=)	single nucleotide variant	not provided [RCV001515255]	Chr2:218135557 [GRCh38] Chr2:219000280 [GRCh37] Chr2:2q35	benign
NM_001557.4(CXCR2):c.936C>T (p.Leu312=)	single nucleotide variant	not provided [RCV001510960]	Chr2:218135737 [GRCh38] Chr2:219000460 [GRCh37] Chr2:2q35	benign
NM_001557.4(CXCR2):c.238C>T (p.Arg80Cys)	single nucleotide variant	not provided [RCV001510710]	Chr2:218135039 [GRCh38] Chr2:218999762 [GRCh37] Chr2:2q35	benign
NM_001557.4(CXCR2):c.786C>T (p.Leu262=)	single nucleotide variant	not provided [RCV001511290]\|not specified [RCV003490273]	Chr2:218135587 [GRCh38] Chr2:219000310 [GRCh37] Chr2:2q35	benign
NM_001557.4(CXCR2):c.768C>T (p.Val256=)	single nucleotide variant	not provided [RCV001519558]	Chr2:218135569 [GRCh38] Chr2:219000292 [GRCh37] Chr2:2q35	benign
NM_001557.4(CXCR2):c.181C>T (p.Leu61=)	single nucleotide variant	CXCR2-related disorder [RCV003931074]\|not provided [RCV001513562]	Chr2:218134982 [GRCh38] Chr2:218999705 [GRCh37] Chr2:2q35	benign\|likely benign
GRCh37/hg19 2q35(chr2:218210665-220141650)	copy number gain	not specified [RCV002053284]	Chr2:218210665..220141650 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.677T>C (p.Ile226Thr)	single nucleotide variant	not provided [RCV001949823]	Chr2:218135478 [GRCh38] Chr2:219000201 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.623G>A (p.Arg208Gln)	single nucleotide variant	WHIM syndrome 2 [RCV001824265]	Chr2:218135424 [GRCh38] Chr2:219000147 [GRCh37] Chr2:2q35	likely pathogenic
NM_001557.4(CXCR2):c.572A>G (p.Asn191Ser)	single nucleotide variant	not provided [RCV001971621]	Chr2:218135373 [GRCh38] Chr2:219000096 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.863G>A (p.Arg288His)	single nucleotide variant	not provided [RCV001950532]	Chr2:218135664 [GRCh38] Chr2:219000387 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.881G>A (p.Arg294Gln)	single nucleotide variant	not provided [RCV001948761]	Chr2:218135682 [GRCh38] Chr2:219000405 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.529G>A (p.Ala177Thr)	single nucleotide variant	not provided [RCV002039975]	Chr2:218135330 [GRCh38] Chr2:219000053 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.461C>T (p.Thr154Ile)	single nucleotide variant	not provided [RCV002005859]	Chr2:218135262 [GRCh38] Chr2:218999985 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.1035G>C (p.Arg345Ser)	single nucleotide variant	not provided [RCV001892788]	Chr2:218135836 [GRCh38] Chr2:219000559 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.180G>C (p.Leu60=)	single nucleotide variant	not provided [RCV001965806]	Chr2:218134981 [GRCh38] Chr2:218999704 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.164A>T (p.Tyr55Phe)	single nucleotide variant	not provided [RCV001889319]\|not specified [RCV004897694]	Chr2:218134965 [GRCh38] Chr2:218999688 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.862C>T (p.Arg288Cys)	single nucleotide variant	not provided [RCV002023728]	Chr2:218135663 [GRCh38] Chr2:219000386 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.650C>T (p.Ser217Phe)	single nucleotide variant	not provided [RCV001963979]\|not specified [RCV004044700]	Chr2:218135451 [GRCh38] Chr2:219000174 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.431G>A (p.Arg144His)	single nucleotide variant	not provided [RCV001928339]	Chr2:218135232 [GRCh38] Chr2:218999955 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.866G>A (p.Arg289His)	single nucleotide variant	not provided [RCV002004617]\|not specified [RCV004043922]	Chr2:218135667 [GRCh38] Chr2:219000390 [GRCh37] Chr2:2q35	uncertain significance
GRCh37/hg19 2q34-36.1(chr2:215108009-221679980)	copy number gain	not specified [RCV002053282]	Chr2:215108009..221679980 [GRCh37] Chr2:2q34-36.1	pathogenic
NM_001557.4(CXCR2):c.742C>T (p.Arg248Trp)	single nucleotide variant	not provided [RCV002018050]	Chr2:218135543 [GRCh38] Chr2:219000266 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.457C>T (p.Arg153Cys)	single nucleotide variant	not provided [RCV001888535]	Chr2:218135258 [GRCh38] Chr2:218999981 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.112C>T (p.Pro38Ser)	single nucleotide variant	not provided [RCV002011809]	Chr2:218134913 [GRCh38] Chr2:218999636 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.883G>A (p.Ala295Thr)	single nucleotide variant	not provided [RCV001933455]	Chr2:218135684 [GRCh38] Chr2:219000407 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.92C>A (p.Pro31His)	single nucleotide variant	not provided [RCV001952150]	Chr2:218134893 [GRCh38] Chr2:218999616 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.931C>A (p.Pro311Thr)	single nucleotide variant	not provided [RCV002013562]	Chr2:218135732 [GRCh38] Chr2:219000455 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.61A>C (p.Ser21Arg)	single nucleotide variant	not provided [RCV002033130]	Chr2:218134862 [GRCh38] Chr2:218999585 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.944C>G (p.Ala315Gly)	single nucleotide variant	not provided [RCV002031412]	Chr2:218135745 [GRCh38] Chr2:219000468 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.854C>A (p.Thr285Asn)	single nucleotide variant	not provided [RCV001989597]	Chr2:218135655 [GRCh38] Chr2:219000378 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.109G>A (p.Ala37Thr)	single nucleotide variant	not provided [RCV001918126]	Chr2:218134910 [GRCh38] Chr2:218999633 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.999C>T (p.Gly333=)	single nucleotide variant	not provided [RCV001866441]	Chr2:218135800 [GRCh38] Chr2:219000523 [GRCh37] Chr2:2q35	likely benign\|uncertain significance
NM_001557.4(CXCR2):c.959A>T (p.Lys320Met)	single nucleotide variant	not provided [RCV001902368]	Chr2:218135760 [GRCh38] Chr2:219000483 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.244G>A (p.Val82Ile)	single nucleotide variant	not provided [RCV001921084]	Chr2:218135045 [GRCh38] Chr2:218999768 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.270A>G (p.Leu90=)	single nucleotide variant	not provided [RCV001951188]	Chr2:218135071 [GRCh38] Chr2:218999794 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.751C>T (p.Arg251Trp)	single nucleotide variant	not provided [RCV001907270]	Chr2:218135552 [GRCh38] Chr2:219000275 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.476G>A (p.Arg159His)	single nucleotide variant	not provided [RCV001999216]	Chr2:218135277 [GRCh38] Chr2:219000000 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.146A>G (p.Tyr49Cys)	single nucleotide variant	not provided [RCV001979904]	Chr2:218134947 [GRCh38] Chr2:218999670 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.865C>T (p.Arg289Cys)	single nucleotide variant	not provided [RCV001925875]	Chr2:218135666 [GRCh38] Chr2:219000389 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.752G>A (p.Arg251Gln)	single nucleotide variant	not provided [RCV001960160]\|not specified [RCV004042103]	Chr2:218135553 [GRCh38] Chr2:219000276 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.746C>A (p.Ala249Asp)	single nucleotide variant	not provided [RCV002026499]	Chr2:218135547 [GRCh38] Chr2:219000270 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.730G>A (p.Gly244Arg)	single nucleotide variant	not provided [RCV001917280]	Chr2:218135531 [GRCh38] Chr2:219000254 [GRCh37] Chr2:2q35	uncertain significance
NC_000002.11:g.(?_218999525)_(220435954_?)dup	duplication	Alacrima, achalasia, and intellectual disability syndrome [RCV001955103]\|Paroxysmal nonkinesigenic dyskinesia [RCV001962531]	Chr2:218999525..220435954 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.204C>T (p.Leu68=)	single nucleotide variant	not provided [RCV002112799]	Chr2:218135005 [GRCh38] Chr2:218999728 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.108C>T (p.Ala36=)	single nucleotide variant	not provided [RCV002107344]	Chr2:218134909 [GRCh38] Chr2:218999632 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.471G>A (p.Gln157=)	single nucleotide variant	not provided [RCV002165679]	Chr2:218135272 [GRCh38] Chr2:218999995 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.531C>T (p.Ala177=)	single nucleotide variant	not provided [RCV002126242]	Chr2:218135332 [GRCh38] Chr2:219000055 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.584C>A (p.Ala195Asp)	single nucleotide variant	not provided [RCV002130726]	Chr2:218135385 [GRCh38] Chr2:219000108 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.84C>T (p.Thr28=)	single nucleotide variant	not provided [RCV002074598]	Chr2:218134885 [GRCh38] Chr2:218999608 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.303G>A (p.Leu101=)	single nucleotide variant	not provided [RCV002128683]	Chr2:218135104 [GRCh38] Chr2:218999827 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.261G>A (p.Leu87=)	single nucleotide variant	not provided [RCV002205829]	Chr2:218135062 [GRCh38] Chr2:218999785 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.348A>G (p.Thr116=)	single nucleotide variant	not provided [RCV002132302]	Chr2:218135149 [GRCh38] Chr2:218999872 [GRCh37] Chr2:2q35	benign
NM_001557.4(CXCR2):c.781C>T (p.Leu261=)	single nucleotide variant	not provided [RCV002174045]	Chr2:218135582 [GRCh38] Chr2:219000305 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.90C>G (p.Pro30=)	single nucleotide variant	CXCR2-related disorder [RCV003893095]\|not provided [RCV002097167]	Chr2:218134891 [GRCh38] Chr2:218999614 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.693C>T (p.Tyr231=)	single nucleotide variant	not provided [RCV002105650]	Chr2:218135494 [GRCh38] Chr2:219000217 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.501C>T (p.Leu167=)	single nucleotide variant	not provided [RCV002151573]	Chr2:218135302 [GRCh38] Chr2:219000025 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.17T>G (p.Met6Arg)	single nucleotide variant	not provided [RCV002172183]	Chr2:218134818 [GRCh38] Chr2:218999541 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.234C>T (p.Val78=)	single nucleotide variant	not provided [RCV002213502]	Chr2:218135035 [GRCh38] Chr2:218999758 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.526C>T (p.Leu176=)	single nucleotide variant	not provided [RCV002185728]	Chr2:218135327 [GRCh38] Chr2:219000050 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.159T>C (p.Ile53=)	single nucleotide variant	not provided [RCV002179223]	Chr2:218134960 [GRCh38] Chr2:218999683 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.975C>T (p.Leu325=)	single nucleotide variant	not provided [RCV002084164]	Chr2:218135776 [GRCh38] Chr2:219000499 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.804C>T (p.Asn268=)	single nucleotide variant	not provided [RCV002184354]	Chr2:218135605 [GRCh38] Chr2:219000328 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.141C>T (p.Asn47=)	single nucleotide variant	not provided [RCV002140430]	Chr2:218134942 [GRCh38] Chr2:218999665 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.995A>G (p.His332Arg)	single nucleotide variant	not provided [RCV002082530]	Chr2:218135796 [GRCh38] Chr2:219000519 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.849G>A (p.Gln283=)	single nucleotide variant	not provided [RCV002751290]	Chr2:218135650 [GRCh38] Chr2:219000373 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.316G>A (p.Ala106Thr)	single nucleotide variant	not provided [RCV002616186]	Chr2:218135117 [GRCh38] Chr2:218999840 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.189G>T (p.Leu63=)	single nucleotide variant	not provided [RCV002614386]	Chr2:218134990 [GRCh38] Chr2:218999713 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.387C>T (p.Asn129=)	single nucleotide variant	not provided [RCV002618836]	Chr2:218135188 [GRCh38] Chr2:218999911 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.223T>C (p.Tyr75His)	single nucleotide variant	not provided [RCV002734891]	Chr2:218135024 [GRCh38] Chr2:218999747 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.1021C>T (p.Pro341Ser)	single nucleotide variant	not provided [RCV002903372]	Chr2:218135822 [GRCh38] Chr2:219000545 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.573T>C (p.Asn191=)	single nucleotide variant	not provided [RCV002613590]	Chr2:218135374 [GRCh38] Chr2:219000097 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.950T>C (p.Ile317Thr)	single nucleotide variant	not provided [RCV002614050]	Chr2:218135751 [GRCh38] Chr2:219000474 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.334T>C (p.Trp112Arg)	single nucleotide variant	not provided [RCV002976018]	Chr2:218135135 [GRCh38] Chr2:218999858 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.913C>G (p.Leu305Val)	single nucleotide variant	not specified [RCV004119080]	Chr2:218135714 [GRCh38] Chr2:219000437 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.1043T>C (p.Phe348Ser)	single nucleotide variant	not provided [RCV003081588]	Chr2:218135844 [GRCh38] Chr2:219000567 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.1041del (p.Phe348fs)	deletion	not provided [RCV002824595]	Chr2:218135841 [GRCh38] Chr2:219000564 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.591T>C (p.Tyr197=)	single nucleotide variant	not provided [RCV002620834]	Chr2:218135392 [GRCh38] Chr2:219000115 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.1047T>G (p.Val349=)	single nucleotide variant	not provided [RCV002871263]	Chr2:218135848 [GRCh38] Chr2:219000571 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.94T>G (p.Phe32Val)	single nucleotide variant	not provided [RCV002796096]	Chr2:218134895 [GRCh38] Chr2:218999618 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.271G>A (p.Ala91Thr)	single nucleotide variant	not provided [RCV002694828]	Chr2:218135072 [GRCh38] Chr2:218999795 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.416G>A (p.Cys139Tyr)	single nucleotide variant	not specified [RCV004164013]	Chr2:218135217 [GRCh38] Chr2:218999940 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.856T>G (p.Cys286Gly)	single nucleotide variant	not provided [RCV002886435]	Chr2:218135657 [GRCh38] Chr2:219000380 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.982A>G (p.Ile328Val)	single nucleotide variant	not provided [RCV002638956]	Chr2:218135783 [GRCh38] Chr2:219000506 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.394A>C (p.Ser132Arg)	single nucleotide variant	not provided [RCV002691169]	Chr2:218135195 [GRCh38] Chr2:218999918 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.172G>A (p.Val58Ile)	single nucleotide variant	not provided [RCV002639749]	Chr2:218134973 [GRCh38] Chr2:218999696 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.148T>C (p.Phe50Leu)	single nucleotide variant	not specified [RCV004225817]	Chr2:218134949 [GRCh38] Chr2:218999672 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.559G>A (p.Val187Ile)	single nucleotide variant	not provided [RCV002785323]	Chr2:218135360 [GRCh38] Chr2:219000083 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.67T>G (p.Tyr23Asp)	single nucleotide variant	not provided [RCV002824555]	Chr2:218134868 [GRCh38] Chr2:218999591 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.43T>C (p.Trp15Arg)	single nucleotide variant	not provided [RCV002952768]	Chr2:218134844 [GRCh38] Chr2:218999567 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.482T>G (p.Leu161Trp)	single nucleotide variant	not provided [RCV002927131]	Chr2:218135283 [GRCh38] Chr2:219000006 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.942C>T (p.Tyr314=)	single nucleotide variant	not provided [RCV002595553]	Chr2:218135743 [GRCh38] Chr2:219000466 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.664G>A (p.Val222Met)	single nucleotide variant	not provided [RCV003082201]	Chr2:218135465 [GRCh38] Chr2:219000188 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.430C>T (p.Arg144Cys)	single nucleotide variant	not provided [RCV002766172]	Chr2:218135231 [GRCh38] Chr2:218999954 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.611C>T (p.Thr204Ile)	single nucleotide variant	not provided [RCV003777633]\|not specified [RCV004088153]	Chr2:218135412 [GRCh38] Chr2:219000135 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.453C>T (p.Ala151=)	single nucleotide variant	not provided [RCV003055885]	Chr2:218135254 [GRCh38] Chr2:218999977 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.524T>A (p.Leu175His)	single nucleotide variant	not specified [RCV004168606]	Chr2:218135325 [GRCh38] Chr2:219000048 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.882G>A (p.Arg294=)	single nucleotide variant	not provided [RCV002894078]	Chr2:218135683 [GRCh38] Chr2:219000406 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.684G>A (p.Leu228=)	single nucleotide variant	not provided [RCV002643493]	Chr2:218135485 [GRCh38] Chr2:219000208 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.153G>C (p.Val51=)	single nucleotide variant	not provided [RCV002765488]	Chr2:218134954 [GRCh38] Chr2:218999677 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.945C>T (p.Ala315=)	single nucleotide variant	not provided [RCV002853292]	Chr2:218135746 [GRCh38] Chr2:219000469 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.475C>T (p.Arg159Cys)	single nucleotide variant	not provided [RCV002625250]\|not specified [RCV004907831]	Chr2:218135276 [GRCh38] Chr2:218999999 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.1080C>A (p.Leu360=)	single nucleotide variant	not provided [RCV002957880]	Chr2:218135881 [GRCh38] Chr2:219000604 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.710C>T (p.Thr237Met)	single nucleotide variant	not provided [RCV003086243]	Chr2:218135511 [GRCh38] Chr2:219000234 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.504C>T (p.Ser168=)	single nucleotide variant	not provided [RCV003030113]	Chr2:218135305 [GRCh38] Chr2:219000028 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.32T>C (p.Phe11Ser)	single nucleotide variant	not provided [RCV002921958]	Chr2:218134833 [GRCh38] Chr2:218999556 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.972A>C (p.Gly324=)	single nucleotide variant	not provided [RCV002895870]	Chr2:218135773 [GRCh38] Chr2:219000496 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.37G>C (p.Asp13His)	single nucleotide variant	not provided [RCV002646010]	Chr2:218134838 [GRCh38] Chr2:218999561 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.594G>A (p.Glu198=)	single nucleotide variant	not provided [RCV002600154]	Chr2:218135395 [GRCh38] Chr2:219000118 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.965G>A (p.Arg322His)	single nucleotide variant	not provided [RCV002649716]	Chr2:218135766 [GRCh38] Chr2:219000489 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.1021C>A (p.Pro341Thr)	single nucleotide variant	not provided [RCV002938529]	Chr2:218135822 [GRCh38] Chr2:219000545 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.829A>T (p.Met277Leu)	single nucleotide variant	not provided [RCV003030692]	Chr2:218135630 [GRCh38] Chr2:219000353 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.281A>G (p.Asp94Gly)	single nucleotide variant	not specified [RCV004182942]	Chr2:218135082 [GRCh38] Chr2:218999805 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.662del (p.Ile221fs)	deletion	not provided [RCV002597602]	Chr2:218135463 [GRCh38] Chr2:219000186 [GRCh37] Chr2:2q35	pathogenic\|uncertain significance
NM_001557.4(CXCR2):c.876C>T (p.Ile292=)	single nucleotide variant	not provided [RCV002598472]	Chr2:218135677 [GRCh38] Chr2:219000400 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.204C>G (p.Leu68=)	single nucleotide variant	not provided [RCV002599449]	Chr2:218135005 [GRCh38] Chr2:218999728 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.528G>T (p.Leu176=)	single nucleotide variant	not provided [RCV002583674]	Chr2:218135329 [GRCh38] Chr2:219000052 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.189G>C (p.Leu63=)	single nucleotide variant	not provided [RCV002815096]	Chr2:218134990 [GRCh38] Chr2:218999713 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.603C>A (p.Gly201=)	single nucleotide variant	not provided [RCV002609443]	Chr2:218135404 [GRCh38] Chr2:219000127 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.940T>C (p.Tyr314His)	single nucleotide variant	not provided [RCV002586038]	Chr2:218135741 [GRCh38] Chr2:219000464 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.315C>T (p.Ala105=)	single nucleotide variant	not provided [RCV002610247]	Chr2:218135116 [GRCh38] Chr2:218999839 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.727A>G (p.Met243Val)	single nucleotide variant	not provided [RCV003073242]\|not specified [RCV004907817]	Chr2:218135528 [GRCh38] Chr2:219000251 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.991A>G (p.Ile331Val)	single nucleotide variant	not provided [RCV002589114]\|not specified [RCV004064513]	Chr2:218135792 [GRCh38] Chr2:219000515 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.1082A>G (p.Ter361=)	single nucleotide variant	not provided [RCV002589126]	Chr2:218135883 [GRCh38] Chr2:219000606 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.185G>A (p.Ser62Asn)	single nucleotide variant	not provided [RCV002722090]	Chr2:218134986 [GRCh38] Chr2:218999709 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.18G>A (p.Met6Ile)	single nucleotide variant	not provided [RCV002583056]	Chr2:218134819 [GRCh38] Chr2:218999542 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.305C>T (p.Pro102Leu)	single nucleotide variant	not provided [RCV004792063]	Chr2:218135106 [GRCh38] Chr2:218999829 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.992T>C (p.Ile331Thr)	single nucleotide variant	not specified [RCV004273259]	Chr2:218135793 [GRCh38] Chr2:219000516 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.228C>G (p.Ser76Arg)	single nucleotide variant	not specified [RCV004266812]	Chr2:218135029 [GRCh38] Chr2:218999752 [GRCh37] Chr2:2q35	uncertain significance
GRCh37/hg19 2q32.1-36.1(chr2:186698504-223918111)x3	copy number gain	See cases [RCV003329558]	Chr2:186698504..223918111 [GRCh37] Chr2:2q32.1-36.1	pathogenic
NM_001557.4(CXCR2):c.1046T>G (p.Val349Gly)	single nucleotide variant	not specified [RCV004348810]	Chr2:218135847 [GRCh38] Chr2:219000570 [GRCh37] Chr2:2q35	uncertain significance
GRCh37/hg19 2q35-37.3(chr2:218376403-242783384)x3	copy number gain	not provided [RCV003484087]	Chr2:218376403..242783384 [GRCh37] Chr2:2q35-37.3	pathogenic
NM_001557.4(CXCR2):c.681G>A (p.Met227Ile)	single nucleotide variant	not provided [RCV003696783]	Chr2:218135482 [GRCh38] Chr2:219000205 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.779T>C (p.Phe260Ser)	single nucleotide variant	not provided [RCV003694154]	Chr2:218135580 [GRCh38] Chr2:219000303 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.877G>A (p.Asp293Asn)	single nucleotide variant	not provided [RCV003543854]	Chr2:218135678 [GRCh38] Chr2:219000401 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.619T>A (p.Trp207Arg)	single nucleotide variant	not provided [RCV003663545]	Chr2:218135420 [GRCh38] Chr2:219000143 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.663C>A (p.Ile221=)	single nucleotide variant	not provided [RCV003576818]	Chr2:218135464 [GRCh38] Chr2:219000187 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.243C>T (p.Ser81=)	single nucleotide variant	not provided [RCV003827979]	Chr2:218135044 [GRCh38] Chr2:218999767 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.294C>T (p.Ala98=)	single nucleotide variant	not provided [RCV003574364]	Chr2:218135095 [GRCh38] Chr2:218999818 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.1057T>C (p.Ser353Pro)	single nucleotide variant	not provided [RCV003687377]	Chr2:218135858 [GRCh38] Chr2:219000581 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.910A>G (p.Ile304Val)	single nucleotide variant	not provided [RCV003701250]	Chr2:218135711 [GRCh38] Chr2:219000434 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.903T>C (p.Ile301=)	single nucleotide variant	not provided [RCV003659494]	Chr2:218135704 [GRCh38] Chr2:219000427 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.1062G>A (p.Gly354=)	single nucleotide variant	not provided [RCV003700755]	Chr2:218135863 [GRCh38] Chr2:219000586 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.75C>T (p.Tyr25=)	single nucleotide variant	not provided [RCV003838572]	Chr2:218134876 [GRCh38] Chr2:218999599 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.630G>A (p.Leu210=)	single nucleotide variant	not provided [RCV003671916]	Chr2:218135431 [GRCh38] Chr2:219000154 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.512G>A (p.Gly171Asp)	single nucleotide variant	not provided [RCV003700575]	Chr2:218135313 [GRCh38] Chr2:219000036 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.272C>T (p.Ala91Val)	single nucleotide variant	not provided [RCV003854515]	Chr2:218135073 [GRCh38] Chr2:218999796 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.221T>C (p.Leu74Ser)	single nucleotide variant	not provided [RCV003697163]	Chr2:218135022 [GRCh38] Chr2:218999745 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.930C>T (p.Asn310=)	single nucleotide variant	not provided [RCV003837766]	Chr2:218135731 [GRCh38] Chr2:219000454 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.140A>G (p.Asn47Ser)	single nucleotide variant	not provided [RCV003837913]	Chr2:218134941 [GRCh38] Chr2:218999664 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.114A>G (p.Pro38=)	single nucleotide variant	not provided [RCV003705224]	Chr2:218134915 [GRCh38] Chr2:218999638 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.78C>T (p.Ser26=)	single nucleotide variant	not provided [RCV003708429]	Chr2:218134879 [GRCh38] Chr2:218999602 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.306del (p.Ile103fs)	deletion	not provided [RCV003679623]	Chr2:218135105 [GRCh38] Chr2:218999828 [GRCh37] Chr2:2q35	pathogenic
NM_001557.4(CXCR2):c.243C>A (p.Ser81=)	single nucleotide variant	not provided [RCV003682043]	Chr2:218135044 [GRCh38] Chr2:218999767 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.534G>C (p.Leu178=)	single nucleotide variant	not provided [RCV003682072]	Chr2:218135335 [GRCh38] Chr2:219000058 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.232G>A (p.Val78Ile)	single nucleotide variant	not provided [RCV003711582]	Chr2:218135033 [GRCh38] Chr2:218999756 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.549C>T (p.Phe183=)	single nucleotide variant	not provided [RCV003842324]	Chr2:218135350 [GRCh38] Chr2:219000073 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.300C>T (p.Thr100=)	single nucleotide variant	not provided [RCV003674413]	Chr2:218135101 [GRCh38] Chr2:218999824 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.597C>T (p.Asp199=)	single nucleotide variant	not provided [RCV003685298]	Chr2:218135398 [GRCh38] Chr2:219000121 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.625A>G (p.Met209Val)	single nucleotide variant	not provided [RCV003867266]	Chr2:218135426 [GRCh38] Chr2:219000149 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.880C>T (p.Arg294Trp)	single nucleotide variant	not provided [RCV003734468]\|not specified [RCV004614511]	Chr2:218135681 [GRCh38] Chr2:219000404 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.27C>T (p.Asp9=)	single nucleotide variant	not provided [RCV003860834]	Chr2:218134828 [GRCh38] Chr2:218999551 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.870T>C (p.Asn290=)	single nucleotide variant	not provided [RCV003864102]	Chr2:218135671 [GRCh38] Chr2:219000394 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.642G>T (p.Leu214=)	single nucleotide variant	not provided [RCV003720492]	Chr2:218135443 [GRCh38] Chr2:219000166 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.644C>G (p.Pro215Arg)	single nucleotide variant	not provided [RCV003682500]	Chr2:218135445 [GRCh38] Chr2:219000168 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.336G>T (p.Trp112Cys)	single nucleotide variant	not provided [RCV003860724]	Chr2:218135137 [GRCh38] Chr2:218999860 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.408_409inv (p.Leu136_Leu137=)	inversion	not provided [RCV003822499]	Chr2:218135209..218135210 [GRCh38] Chr2:218999932..218999933 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.624G>A (p.Arg208=)	single nucleotide variant	not provided [RCV003565962]	Chr2:218135425 [GRCh38] Chr2:219000148 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.190C>A (p.Leu64Met)	single nucleotide variant	not provided [RCV003842363]	Chr2:218134991 [GRCh38] Chr2:218999714 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.694G>A (p.Gly232Arg)	single nucleotide variant	not provided [RCV003705611]	Chr2:218135495 [GRCh38] Chr2:219000218 [GRCh37] Chr2:2q35	uncertain significance
GRCh37/hg19 2q35-37.3(chr2:216815496-242782258)x3	copy number gain	See cases [RCV004442836]	Chr2:216815496..242782258 [GRCh37] Chr2:2q35-37.3	pathogenic
NM_001557.4(CXCR2):c.458G>C (p.Arg153Pro)	single nucleotide variant	not specified [RCV004367595]	Chr2:218135259 [GRCh38] Chr2:218999982 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.569C>T (p.Ser190Phe)	single nucleotide variant	not specified [RCV004367596]	Chr2:218135370 [GRCh38] Chr2:219000093 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.654T>C (p.Phe218=)	single nucleotide variant	CXCR2-related disorder [RCV003893799]	Chr2:218135455 [GRCh38] Chr2:219000178 [GRCh37] Chr2:2q35	likely benign
NM_001557.4(CXCR2):c.898G>A (p.Glu300Lys)	single nucleotide variant	not specified [RCV004616198]	Chr2:218135699 [GRCh38] Chr2:219000422 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.892G>A (p.Ala298Thr)	single nucleotide variant	not specified [RCV004616202]	Chr2:218135693 [GRCh38] Chr2:219000416 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.745G>T (p.Ala249Ser)	single nucleotide variant	not specified [RCV004616200]	Chr2:218135546 [GRCh38] Chr2:219000269 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.824C>A (p.Thr275Asn)	single nucleotide variant	not specified [RCV004616199]	Chr2:218135625 [GRCh38] Chr2:219000348 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.1016C>A (p.Ser339Tyr)	single nucleotide variant	not specified [RCV004911049]	Chr2:218135817 [GRCh38] Chr2:219000540 [GRCh37] Chr2:2q35	uncertain significance
NM_001557.4(CXCR2):c.7G>A (p.Asp3Asn)	single nucleotide variant	not specified [RCV004911048]	Chr2:218134808 [GRCh38] Chr2:218999531 [GRCh37] Chr2:2q35	uncertain significance

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	1841
Count of miRNA genes:	736
Interacting mature miRNAs:	825
Transcripts:	ENST00000318507, ENST00000415392, ENST00000418878, ENST00000428565, ENST00000449014, ENST00000453237, ENST00000454148
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCh38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
597611038	GWAS1667898_H	neutrophil count QTL GWAS1667898 (human)		9e-20	neutrophil quantity (VT:0000222)	blood neutrophil count (CMO:0000030)	2	218135259	218135260	Human
597081812	GWAS1177886_H	lymphocyte percentage of leukocytes QTL GWAS1177886 (human)		8e-66	lymphocyte quantity (VT:0000717)	blood lymphocyte count to total leukocyte count ratio (CMO:0000371)	2	218135259	218135260	Human
597061589	GWAS1157663_H	basophil count QTL GWAS1157663 (human)		4e-23	basophil quantity (VT:0002607)	blood basophil count (CMO:0000034)	2	218135259	218135260	Human
597081813	GWAS1177887_H	lymphocyte percentage of leukocytes QTL GWAS1177887 (human)		1e-11	lymphocyte quantity (VT:0000717)	blood lymphocyte count to total leukocyte count ratio (CMO:0000371)	2	218135544	218135545	Human
407008326	GWAS657302_H	neutrophil count QTL GWAS657302 (human)		6e-143	neutrophil quantity (VT:0000222)	blood neutrophil count (CMO:0000030)	2	218135259	218135260	Human
597081874	GWAS1177948_H	neutrophil count QTL GWAS1177948 (human)		2e-143	neutrophil quantity (VT:0000222)	blood neutrophil count (CMO:0000030)	2	218135259	218135260	Human
597610906	GWAS1667766_H	neutrophil count QTL GWAS1667766 (human)		2e-25	neutrophil quantity (VT:0000222)	blood neutrophil count (CMO:0000030)	2	218135259	218135260	Human
597103954	GWAS1200028_H	neutrophil count QTL GWAS1200028 (human)		4e-09	neutrophil quantity (VT:0000222)	blood neutrophil count (CMO:0000030)	2	218135507	218135508	Human
597103953	GWAS1200027_H	neutrophil count QTL GWAS1200027 (human)		5e-127	neutrophil quantity (VT:0000222)	blood neutrophil count (CMO:0000030)	2	218135259	218135260	Human
597195984	GWAS1292058_H	lean body mass QTL GWAS1292058 (human)		3e-08	body lean mass (VT:0010483)	total body lean mass (CMO:0003950)	2	218126824	218126828	Human
406957515	GWAS606491_H	neutrophil count, eosinophil count QTL GWAS606491 (human)		2e-41	eosinophil quantity (VT:0002602)	blood eosinophil count (CMO:0000033)	2	218135259	218135260	Human
597101021	GWAS1197095_H	neutrophil percentage of leukocytes QTL GWAS1197095 (human)		5e-14	neutrophil quantity (VT:0000222)	blood neutrophil count to total leukocyte count ratio (CMO:0000370)	2	218135544	218135545	Human
597101020	GWAS1197094_H	neutrophil percentage of leukocytes QTL GWAS1197094 (human)		9e-74	neutrophil quantity (VT:0000222)	blood neutrophil count to total leukocyte count ratio (CMO:0000370)	2	218135259	218135260	Human
597167765	GWAS1263839_H	basophil count QTL GWAS1263839 (human)		2e-13	basophil quantity (VT:0002607)	blood basophil count (CMO:0000034)	2	218135259	218135260	Human
597119706	GWAS1215780_H	neutrophil count QTL GWAS1215780 (human)		4e-28	neutrophil quantity (VT:0000222)	blood neutrophil count (CMO:0000030)	2	218135544	218135545	Human
2289332	BW376_H	Body weight QTL 376 (human)	1.87	0.00168	Body fat amount	abdominal	2	213765566	239765566	Human
597104960	GWAS1201034_H	neutrophil count QTL GWAS1201034 (human)		6e-21	neutrophil quantity (VT:0000222)	blood neutrophil count (CMO:0000030)	2	218135544	218135545	Human
597302401	GWAS1398475_H	neutrophil count QTL GWAS1398475 (human)		7e-99	neutrophil quantity (VT:0000222)	blood neutrophil count (CMO:0000030)	2	218135259	218135260	Human
406974431	GWAS623407_H	neutrophil count QTL GWAS623407 (human)		7e-42	neutrophil quantity (VT:0000222)	blood neutrophil count (CMO:0000030)	2	218135259	218135260	Human
406963038	GWAS612014_H	granulocyte percentage of myeloid white cells QTL GWAS612014 (human)		1e-20	granulocyte quantity (VT:0000334)		2	218135259	218135260	Human
406977125	GWAS626101_H	neutrophil count, basophil count QTL GWAS626101 (human)		4e-42	basophil quantity (VT:0002607)	blood granulocyte count (CMO:0000111)	2	218135259	218135260	Human
597160825	GWAS1256899_H	IGA glomerulonephritis QTL GWAS1256899 (human)		0.000004	IGA glomerulonephritis		2	218126282	218126283	Human
597611120	GWAS1667980_H	neutrophil count QTL GWAS1667980 (human)		4e-13	neutrophil quantity (VT:0000222)	blood neutrophil count (CMO:0000030)	2	218135259	218135260	Human
1643254	BW125_H	Body Weight QTL 125 (human)	1.45	0.005	Body weight	body mass index	2	200715236	226715236	Human
2293458	PRSTS291_H	Prostate tumor susceptibility QTL 291 (human)		0.012	Prostate tumor susceptibility		2	200715236	226715236	Human
406889840	GWAS538816_H	lymphocyte percentage of leukocytes QTL GWAS538816 (human)		3e-20	lymphocyte quantity (VT:0000717)	blood granulocyte count (CMO:0000111)	2	218135259	218135260	Human
1643053	BW117_H	Body Weight QTL 117 (human)	2.4	0.00044	Body weight		2	200715236	226715236	Human
406893816	GWAS542792_H	neutrophil percentage of leukocytes QTL GWAS542792 (human)		3e-25	neutrophil quantity (VT:0000222)	blood neutrophil count to total leukocyte count ratio (CMO:0000370)	2	218135259	218135260	Human
406960187	GWAS609163_H	monocyte percentage of leukocytes QTL GWAS609163 (human)		5e-11	monocyte quantity (VT:0000223)	blood monocyte count to total leukocyte count ratio (CMO:0000374)	2	218135259	218135260	Human
406960765	GWAS609741_H	granulocyte count QTL GWAS609741 (human)		8e-42	granulocyte quantity (VT:0000334)	blood granulocyte count (CMO:0000111)	2	218135259	218135260	Human
597084331	GWAS1180405_H	monocyte percentage of leukocytes QTL GWAS1180405 (human)		1e-27	monocyte quantity (VT:0000223)	blood monocyte count to total leukocyte count ratio (CMO:0000374)	2	218135259	218135260	Human

Markers in Region

SHGC-35278

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	2	219,000,660 - 219,000,876	UniSTS	GRCh37
GRCh37	2	218,924,793 - 218,925,009	UniSTS	GRCh37
Build 36	2	218,633,038 - 218,633,254	RGD	NCBI36
Celera	2	212,767,094 - 212,767,310	UniSTS
Celera	2	212,692,681 - 212,692,897	RGD
Cytogenetic Map	2	q35	UniSTS
HuRef	2	210,779,165 - 210,779,381	UniSTS
HuRef	2	210,853,415 - 210,853,631	UniSTS
Stanford-G3 RH Map	2	8615.0	UniSTS
GeneMap99-GB4 RH Map	2	679.36	UniSTS
Whitehead-RH Map	2	1009.2	UniSTS
NCBI RH Map	2	1775.4	UniSTS
GeneMap99-G3 RH Map	2	9454.0	UniSTS

RH69171

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	2	219,000,583 - 219,000,782	UniSTS	GRCh37
GRCh37	2	218,924,887 - 218,925,086	UniSTS	GRCh37
Build 36	2	218,633,132 - 218,633,331	RGD	NCBI36
Celera	2	212,767,017 - 212,767,216	UniSTS
Celera	2	212,692,775 - 212,692,974	RGD
Cytogenetic Map	2	q35	UniSTS
HuRef	2	210,779,259 - 210,779,458	UniSTS
HuRef	2	210,853,338 - 210,853,537	UniSTS
GeneMap99-GB4 RH Map	2	680.95	UniSTS

IL8R-1

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	2	218,999,980 - 219,000,502	UniSTS	GRCh37
Build 36	2	218,708,225 - 218,708,747	RGD	NCBI36
Celera	2	212,766,414 - 212,766,936	RGD
HuRef	2	210,852,735 - 210,853,257	UniSTS

PMC135988P2

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	2	218,999,631 - 219,000,057	UniSTS	GRCh37
Build 36	2	218,707,876 - 218,708,302	RGD	NCBI36
Celera	2	212,766,065 - 212,766,491	RGD
Cytogenetic Map	2	q35	UniSTS
HuRef	2	210,852,386 - 210,852,812	UniSTS

PMC155779P1

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	2	219,000,289 - 219,000,478	UniSTS	GRCh37
GRCh37	2	219,029,009 - 219,029,197	UniSTS	GRCh37
Build 36	2	218,708,534 - 218,708,723	RGD	NCBI36
Celera	2	212,795,594 - 212,795,782	UniSTS
Celera	2	212,766,723 - 212,766,912	RGD
Cytogenetic Map	2	q35	UniSTS
HuRef	2	210,881,752 - 210,881,940	UniSTS

PMC155779P2

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	2	218,999,843 - 219,000,478	UniSTS	GRCh37
GRCh37	2	219,029,009 - 219,029,643	UniSTS	GRCh37
Build 36	2	218,708,088 - 218,708,723	RGD	NCBI36
Celera	2	212,795,594 - 212,796,228	UniSTS
Celera	2	212,766,277 - 212,766,912	RGD
Cytogenetic Map	2	q35	UniSTS
HuRef	2	210,881,752 - 210,882,386	UniSTS

PMC155779P3

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	2	218,999,843 - 219,000,092	UniSTS	GRCh37
Build 36	2	218,708,088 - 218,708,337	RGD	NCBI36
Celera	2	212,766,277 - 212,766,526	RGD
Cytogenetic Map	2	q35	UniSTS
HuRef	2	210,852,598 - 210,852,847	UniSTS

PMC310709P2

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	2	218,999,774 - 219,000,219	UniSTS	GRCh37
GRCh37	2	218,925,450 - 218,925,894	UniSTS	GRCh37
Build 36	2	218,633,695 - 218,634,139	RGD	NCBI36
Celera	2	212,693,338 - 212,693,782	RGD
Celera	2	212,766,208 - 212,766,653	UniSTS
Cytogenetic Map	2	q35	UniSTS
HuRef	2	210,882,009 - 210,882,455	UniSTS
HuRef	2	210,779,822 - 210,780,266	UniSTS
HuRef	2	210,852,529 - 210,852,974	UniSTS

IL8RB_163

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	2	219,001,235 - 219,002,016	UniSTS	GRCh37
Build 36	2	218,709,480 - 218,710,261	RGD	NCBI36
Celera	2	212,767,670 - 212,768,451	RGD
HuRef	2	210,853,991 - 210,854,772	UniSTS

RH78907

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	2	219,001,678 - 219,001,862	UniSTS	GRCh37
Build 36	2	218,709,923 - 218,710,107	RGD	NCBI36
Celera	2	212,768,113 - 212,768,297	RGD
Cytogenetic Map	2	q35	UniSTS
HuRef	2	210,854,434 - 210,854,618	UniSTS

STS-L19593

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	2	219,000,611 - 219,000,813	UniSTS	GRCh37
GRCh37	2	218,924,856 - 218,925,057	UniSTS	GRCh37
Build 36	2	218,633,101 - 218,633,302	RGD	NCBI36
Celera	2	212,767,045 - 212,767,247	UniSTS
Celera	2	212,692,744 - 212,692,945	RGD
Cytogenetic Map	2	q35	UniSTS
HuRef	2	210,779,228 - 210,779,429	UniSTS
HuRef	2	210,853,366 - 210,853,568	UniSTS
NCBI RH Map	2	1734.1	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	entire extraembryonic component	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system
1203	2280	2718	2185	4699	1651	2111	5	582	1822	423	2203	6888	6258	12	3506	785	1614	1423	169

Sequence

Nucleotide Sequences


RefSeq Transcripts	NG_052975	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001168298	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001557	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005246530	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017003990	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017003991	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017003992	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_047444187	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_047444188	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_047444189	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_047444190	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_047444191	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054341821	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054341822	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054341823	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054341824	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054341825	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054341826	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB032733	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB032734	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC124768	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AH005384	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AJ710879	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK290906	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK312664	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY714242	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC037961	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471063	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068276	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DA670033	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DA674925	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HI519532	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L19593	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M73969	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M94582	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M99412	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U11872	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U11873	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U11874	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U11875	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U11876	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U11877	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U11878	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENST00000318507 ⟹ ENSP00000319635

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	2	218,126,028 - 218,137,251 (+)	Ensembl

Ensembl Acc Id:

ENST00000415392 ⟹ ENSP00000392348

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	2	218,125,681 - 218,135,216 (+)	Ensembl

Ensembl Acc Id:

ENST00000418878 ⟹ ENSP00000416815

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	2	218,130,850 - 218,134,846 (+)	Ensembl

Ensembl Acc Id:

ENST00000428565 ⟹ ENSP00000392698

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	2	218,129,287 - 218,135,318 (+)	Ensembl

Ensembl Acc Id:

ENST00000449014 ⟹ ENSP00000410506

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	2	218,125,705 - 218,134,846 (+)	Ensembl

Ensembl Acc Id:

ENST00000453237 ⟹ ENSP00000413686

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	2	218,125,289 - 218,135,403 (+)	Ensembl

Ensembl Acc Id:

ENST00000454148 ⟹ ENSP00000415148

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	2	218,126,019 - 218,135,208 (+)	Ensembl

RefSeq Acc Id:

NM_001168298 ⟹ NP_001161770

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	2	218,125,294 - 218,137,251 (+)	NCBI
GRCh37	2	218,990,013 - 219,001,976 (+)	NCBI
HuRef	2	210,842,767 - 210,854,732 (+)	ENTREZGENE
CHM1_1	2	218,996,503 - 219,008,469 (+)	NCBI
T2T-CHM13v2.0	2	218,610,987 - 218,622,946 (+)	NCBI

Sequence:

show sequence

AGTGGTGATAGCTGAGAATATGCAGCCGTTTTCTCCTTCCTGGGTACAGTGCTATTCTGCCTAG
AGCTCTGACTACCACCCAACCTTGAGGCACAGTGAAGACATCGGTGGCCACTCCAATAACAGCA
GGTCACAGCTGCTCTTCTGGAGGTGTCCTACAGGTGAAAAGCCCAGCGACCCAGTCAGGATTTA
AGTTTACCTCAAAAATGGAAGATTTTAACATGGAGAGTGACAGCTTTGAAGATTTCTGGAAAGG
TGAAGATCTTAGTAATTACAGTTACAGCTCTACCCTGCCCCCTTTTCTACTAGATGCCGCCCCA
TGTGAACCAGAATCCCTGGAAATCAACAAGTATTTTGTGGTCATTATCTATGCCCTGGTATTCC
TGCTGAGCCTGCTGGGAAACTCCCTCGTGATGCTGGTCATCTTATACAGCAGGGTCGGCCGCTC
CGTCACTGATGTCTACCTGCTGAACCTAGCCTTGGCCGACCTACTCTTTGCCCTGACCTTGCCC
ATCTGGGCCGCCTCCAAGGTGAATGGCTGGATTTTTGGCACATTCCTGTGCAAGGTGGTCTCAC
TCCTGAAGGAAGTCAACTTCTATAGTGGCATCCTGCTACTGGCCTGCATCAGTGTGGACCGTTA
CCTGGCCATTGTCCATGCCACACGCACACTGACCCAGAAGCGCTACTTGGTCAAATTCATATGT
CTCAGCATCTGGGGTCTGTCCTTGCTCCTGGCCCTGCCTGTCTTACTTTTCCGAAGGACCGTCT
ACTCATCCAATGTTAGCCCAGCCTGCTATGAGGACATGGGCAACAATACAGCAAACTGGCGGAT
GCTGTTACGGATCCTGCCCCAGTCCTTTGGCTTCATCGTGCCACTGCTGATCATGCTGTTCTGC
TACGGATTCACCCTGCGTACGCTGTTTAAGGCCCACATGGGGCAGAAGCACCGGGCCATGCGGG
TCATCTTTGCTGTCGTCCTCATCTTCCTGCTCTGCTGGCTGCCCTACAACCTGGTCCTGCTGGC
AGACACCCTCATGAGGACCCAGGTGATCCAGGAGACCTGTGAGCGCCGCAATCACATCGACCGG
GCTCTGGATGCCACCGAGATTCTGGGCATCCTTCACAGCTGCCTCAACCCCCTCATCTACGCCT
TCATTGGCCAGAAGTTTCGCCATGGACTCCTCAAGATTCTAGCTATACATGGCTTGATCAGCAA
GGACTCCCTGCCCAAAGACAGCAGGCCTTCCTTTGTTGGCTCTTCTTCAGGGCACACTTCCACT
ACTCTCTAAGACCTCCTGCCTAAGTGCAGCCCCGTGGGGTTCCTCCCTTCTCTTCACAGTCACA
TTCCAAGCCTCATGTCCACTGGTTCTTCTTGGTCTCAGTGTCAATGCAGCCCCCATTGTGGTCA
CAGGAAGTAGAGGAGGCCACGTTCTTACTAGTTTCCCTTGCATGGTTTAGAAAGCTTGCCCTGG
TGCCTCACCCCTTGCCATAATTACTATGTCATTTGCTGGAGCTCTGCCCATCCTGCCCCTGAGC
CCATGGCACTCTATGTTCTAAGAAGTGAAAATCTACACTCCAGTGAGACAGCTCTGCATACTCA
TTAGGATGGCTAGTATCAAAAGAAAGAAAATCAGGCTGGCCAACGGGGTGAAACCCTGTCTCTA
CTAAAAATACAAAAAAAAAAAAAAATTAGCCGGGCGTGGTGGTGAGTGCCTGTAATCACAGCTA
CTTGGGAGGCTGAGATGGGAGAATCACTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCCGAGAT
TGTGCCCCTGCACTCCAGCCTGAGCGACAGTGAGACTCTGTCTCAGTCCATGAAGATGTAGAGG
AGAAACTGGAACTCTCGAGCGTTGCTGGGGGGGATTGTAAAATGGTGTGACCACTGCAGAAGAC
AGTATGGCAGCTTTCCTCAAAACTTCAGACATAGAATTAACACATGATCCTGCAATTCCACTTA
TAGGAATTGACCCACAAGAAATGAAAGCAGGGACTTGAACCCATATTTGTACACCAATATTCAT
AGCAGCTTATTCACAAGACCCAAAAGGCAGAAGCAACCCAAATGTTCATCAATGAATGAATGAA
TGGCTAAGCAAAATGTGATATGTACCTAACGAAGTATCCTTCAGCCTGAAAGAGGAATGAAGTA
CTCATACATGTTACAACACGGACGAACCTTGAAAACTTTATGCTAAGTGAAATAAGCCAGACAT
CAACAGATAAATAGTTTATGATTCCACCTACATGAGGTACTGAGAGTGAACAAATTTACAGAGA
CAGAAAGCAGAACAGTGATTACCAGGGACTGAGGGGAGGGGAGCATGGGAAGTGACGGTTTAAT
GGGCACAGGGTTTATGTTTAGGATGTTGAAAAAGTTCTGCAGATAAACAGTAGTGATAGTTGTA
CCGCAATGTGACTTAATGCCACTAAATTGACACTTAAAAATGGTTTAAATGGTCAATTTTGTTA
TGTATATTTTATATCAATTTAAAAAAAAACCTGAGCCCCAAAAGGTATTTTAATCACCAAGGCT
GATTAAACCAAGGCTAGAACCACCTGCCTATATTTTTTGTTAAATGATTTCATTCAATATCTTT
TTTTTAATAAACCATTTTTACTTGGGTGTTTA

hide sequence

RefSeq Acc Id:

NM_001557 ⟹ NP_001548

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	2	218,126,028 - 218,137,251 (+)	NCBI
GRCh37	2	218,990,013 - 219,001,976 (+)	ENTREZGENE
GRCh37	2	218,990,013 - 219,001,976 (+)	NCBI
Build 36	2	218,698,991 - 218,710,220 (+)	NCBI Archive
HuRef	2	210,842,767 - 210,854,732 (+)	ENTREZGENE
CHM1_1	2	218,997,225 - 219,008,469 (+)	NCBI
T2T-CHM13v2.0	2	218,611,719 - 218,622,946 (+)	NCBI

Sequence:

show sequence

AGAGACAGAAGGTGGATAGACAAATCTCCACCTTCAGACTGGTAGGCTCCTCCAGAAGCCATCA
GACAGGAAGATGTGAAAATCCCCAGCACTCATCCCAGAATCACTAAGTGGCACCTGTCCTGGGC
CAAAGTCCCAGGACAGACCTCATTGTTCCTCTGTGGGAATACCTCCCCAGGAGGGCATCCTGGA
TTTCCCCCTTGCAACCCAGGTCAGAAGTTTCATCGTCAAGGTTGTTTCATCTTTTTTTTCCTGT
CTAACAGCTCTGACTACCACCCAACCTTGAGGCACAGTGAAGACATCGGTGGCCACTCCAATAA
CAGCAGGTCACAGCTGCTCTTCTGGAGGTGTCCTACAGGTGAAAAGCCCAGCGACCCAGTCAGG
ATTTAAGTTTACCTCAAAAATGGAAGATTTTAACATGGAGAGTGACAGCTTTGAAGATTTCTGG
AAAGGTGAAGATCTTAGTAATTACAGTTACAGCTCTACCCTGCCCCCTTTTCTACTAGATGCCG
CCCCATGTGAACCAGAATCCCTGGAAATCAACAAGTATTTTGTGGTCATTATCTATGCCCTGGT
ATTCCTGCTGAGCCTGCTGGGAAACTCCCTCGTGATGCTGGTCATCTTATACAGCAGGGTCGGC
CGCTCCGTCACTGATGTCTACCTGCTGAACCTAGCCTTGGCCGACCTACTCTTTGCCCTGACCT
TGCCCATCTGGGCCGCCTCCAAGGTGAATGGCTGGATTTTTGGCACATTCCTGTGCAAGGTGGT
CTCACTCCTGAAGGAAGTCAACTTCTATAGTGGCATCCTGCTACTGGCCTGCATCAGTGTGGAC
CGTTACCTGGCCATTGTCCATGCCACACGCACACTGACCCAGAAGCGCTACTTGGTCAAATTCA
TATGTCTCAGCATCTGGGGTCTGTCCTTGCTCCTGGCCCTGCCTGTCTTACTTTTCCGAAGGAC
CGTCTACTCATCCAATGTTAGCCCAGCCTGCTATGAGGACATGGGCAACAATACAGCAAACTGG
CGGATGCTGTTACGGATCCTGCCCCAGTCCTTTGGCTTCATCGTGCCACTGCTGATCATGCTGT
TCTGCTACGGATTCACCCTGCGTACGCTGTTTAAGGCCCACATGGGGCAGAAGCACCGGGCCAT
GCGGGTCATCTTTGCTGTCGTCCTCATCTTCCTGCTCTGCTGGCTGCCCTACAACCTGGTCCTG
CTGGCAGACACCCTCATGAGGACCCAGGTGATCCAGGAGACCTGTGAGCGCCGCAATCACATCG
ACCGGGCTCTGGATGCCACCGAGATTCTGGGCATCCTTCACAGCTGCCTCAACCCCCTCATCTA
CGCCTTCATTGGCCAGAAGTTTCGCCATGGACTCCTCAAGATTCTAGCTATACATGGCTTGATC
AGCAAGGACTCCCTGCCCAAAGACAGCAGGCCTTCCTTTGTTGGCTCTTCTTCAGGGCACACTT
CCACTACTCTCTAAGACCTCCTGCCTAAGTGCAGCCCCGTGGGGTTCCTCCCTTCTCTTCACAG
TCACATTCCAAGCCTCATGTCCACTGGTTCTTCTTGGTCTCAGTGTCAATGCAGCCCCCATTGT
GGTCACAGGAAGTAGAGGAGGCCACGTTCTTACTAGTTTCCCTTGCATGGTTTAGAAAGCTTGC
CCTGGTGCCTCACCCCTTGCCATAATTACTATGTCATTTGCTGGAGCTCTGCCCATCCTGCCCC
TGAGCCCATGGCACTCTATGTTCTAAGAAGTGAAAATCTACACTCCAGTGAGACAGCTCTGCAT
ACTCATTAGGATGGCTAGTATCAAAAGAAAGAAAATCAGGCTGGCCAACGGGGTGAAACCCTGT
CTCTACTAAAAATACAAAAAAAAAAAAAAATTAGCCGGGCGTGGTGGTGAGTGCCTGTAATCAC
AGCTACTTGGGAGGCTGAGATGGGAGAATCACTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCC
GAGATTGTGCCCCTGCACTCCAGCCTGAGCGACAGTGAGACTCTGTCTCAGTCCATGAAGATGT
AGAGGAGAAACTGGAACTCTCGAGCGTTGCTGGGGGGGATTGTAAAATGGTGTGACCACTGCAG
AAGACAGTATGGCAGCTTTCCTCAAAACTTCAGACATAGAATTAACACATGATCCTGCAATTCC
ACTTATAGGAATTGACCCACAAGAAATGAAAGCAGGGACTTGAACCCATATTTGTACACCAATA
TTCATAGCAGCTTATTCACAAGACCCAAAAGGCAGAAGCAACCCAAATGTTCATCAATGAATGA
ATGAATGGCTAAGCAAAATGTGATATGTACCTAACGAAGTATCCTTCAGCCTGAAAGAGGAATG
AAGTACTCATACATGTTACAACACGGACGAACCTTGAAAACTTTATGCTAAGTGAAATAAGCCA
GACATCAACAGATAAATAGTTTATGATTCCACCTACATGAGGTACTGAGAGTGAACAAATTTAC
AGAGACAGAAAGCAGAACAGTGATTACCAGGGACTGAGGGGAGGGGAGCATGGGAAGTGACGGT
TTAATGGGCACAGGGTTTATGTTTAGGATGTTGAAAAAGTTCTGCAGATAAACAGTAGTGATAG
TTGTACCGCAATGTGACTTAATGCCACTAAATTGACACTTAAAAATGGTTTAAATGGTCAATTT
TGTTATGTATATTTTATATCAATTTAAAAAAAAACCTGAGCCCCAAAAGGTATTTTAATCACCA
AGGCTGATTAAACCAAGGCTAGAACCACCTGCCTATATTTTTTGTTAAATGATTTCATTCAATA
TCTTTTTTTTAATAAACCATTTTTACTTGGGTGTTTA

hide sequence

RefSeq Acc Id:

XM_005246530 ⟹ XP_005246587

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	2	218,126,028 - 218,137,251 (+)	NCBI

Sequence:

show sequence

AAAACATTCAGAGACAGAAGGTGGATAGACAAATCTCCACCTTCAGACTGCTCTGACTACCACC
CAACCTTGAGGCACAGTGAAGACATCGGTGGCCACTCCAATAACAGCAGGTCACAGCTGCTCTT
CTGGAGGTGTCCTACAGGTGAAAAGCCCAGCGACCCAGTCAGGATTTAAGTTTACCTCAAAAAT
GGAAGATTTTAACATGGAGAGTGACAGCTTTGAAGATTTCTGGAAAGGTGAAGATCTTAGTAAT
TACAGTTACAGCTCTACCCTGCCCCCTTTTCTACTAGATGCCGCCCCATGTGAACCAGAATCCC
TGGAAATCAACAAGTATTTTGTGGTCATTATCTATGCCCTGGTATTCCTGCTGAGCCTGCTGGG
AAACTCCCTCGTGATGCTGGTCATCTTATACAGCAGGGTCGGCCGCTCCGTCACTGATGTCTAC
CTGCTGAACCTAGCCTTGGCCGACCTACTCTTTGCCCTGACCTTGCCCATCTGGGCCGCCTCCA
AGGTGAATGGCTGGATTTTTGGCACATTCCTGTGCAAGGTGGTCTCACTCCTGAAGGAAGTCAA
CTTCTATAGTGGCATCCTGCTACTGGCCTGCATCAGTGTGGACCGTTACCTGGCCATTGTCCAT
GCCACACGCACACTGACCCAGAAGCGCTACTTGGTCAAATTCATATGTCTCAGCATCTGGGGTC
TGTCCTTGCTCCTGGCCCTGCCTGTCTTACTTTTCCGAAGGACCGTCTACTCATCCAATGTTAG
CCCAGCCTGCTATGAGGACATGGGCAACAATACAGCAAACTGGCGGATGCTGTTACGGATCCTG
CCCCAGTCCTTTGGCTTCATCGTGCCACTGCTGATCATGCTGTTCTGCTACGGATTCACCCTGC
GTACGCTGTTTAAGGCCCACATGGGGCAGAAGCACCGGGCCATGCGGGTCATCTTTGCTGTCGT
CCTCATCTTCCTGCTCTGCTGGCTGCCCTACAACCTGGTCCTGCTGGCAGACACCCTCATGAGG
ACCCAGGTGATCCAGGAGACCTGTGAGCGCCGCAATCACATCGACCGGGCTCTGGATGCCACCG
AGATTCTGGGCATCCTTCACAGCTGCCTCAACCCCCTCATCTACGCCTTCATTGGCCAGAAGTT
TCGCCATGGACTCCTCAAGATTCTAGCTATACATGGCTTGATCAGCAAGGACTCCCTGCCCAAA
GACAGCAGGCCTTCCTTTGTTGGCTCTTCTTCAGGGCACACTTCCACTACTCTCTAAGACCTCC
TGCCTAAGTGCAGCCCCGTGGGGTTCCTCCCTTCTCTTCACAGTCACATTCCAAGCCTCATGTC
CACTGGTTCTTCTTGGTCTCAGTGTCAATGCAGCCCCCATTGTGGTCACAGGAAGTAGAGGAGG
CCACGTTCTTACTAGTTTCCCTTGCATGGTTTAGAAAGCTTGCCCTGGTGCCTCACCCCTTGCC
ATAATTACTATGTCATTTGCTGGAGCTCTGCCCATCCTGCCCCTGAGCCCATGGCACTCTATGT
TCTAAGAAGTGAAAATCTACACTCCAGTGAGACAGCTCTGCATACTCATTAGGATGGCTAGTAT
CAAAAGAAAGAAAATCAGGCTGGCCAACGGGGTGAAACCCTGTCTCTACTAAAAATACAAAAAA
AAAAAAAAATTAGCCGGGCGTGGTGGTGAGTGCCTGTAATCACAGCTACTTGGGAGGCTGAGAT
GGGAGAATCACTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCCGAGATTGTGCCCCTGCACTCC
AGCCTGAGCGACAGTGAGACTCTGTCTCAGTCCATGAAGATGTAGAGGAGAAACTGGAACTCTC
GAGCGTTGCTGGGGGGGATTGTAAAATGGTGTGACCACTGCAGAAGACAGTATGGCAGCTTTCC
TCAAAACTTCAGACATAGAATTAACACATGATCCTGCAATTCCACTTATAGGAATTGACCCACA
AGAAATGAAAGCAGGGACTTGAACCCATATTTGTACACCAATATTCATAGCAGCTTATTCACAA
GACCCAAAAGGCAGAAGCAACCCAAATGTTCATCAATGAATGAATGAATGGCTAAGCAAAATGT
GATATGTACCTAACGAAGTATCCTTCAGCCTGAAAGAGGAATGAAGTACTCATACATGTTACAA
CACGGACGAACCTTGAAAACTTTATGCTAAGTGAAATAAGCCAGACATCAACAGATAAATAGTT
TATGATTCCACCTACATGAGGTACTGAGAGTGAACAAATTTACAGAGACAGAAAGCAGAACAGT
GATTACCAGGGACTGAGGGGAGGGGAGCATGGGAAGTGACGGTTTAATGGGCACAGGGTTTATG
TTTAGGATGTTGAAAAAGTTCTGCAGATAAACAGTAGTGATAGTTGTACCGCAATGTGACTTAA
TGCCACTAAATTGACACTTAAAAATGGTTTAAATGGTCAATTTTGTTATGTATATTTTATATCA
ATTTAAAAAAAAACCTGAGCCCCAAAAGGTATTTTAATCACCAAGGCTGATTAAACCAAGGCTA
GAACCACCTGCCTATATTTTTTGTTAAATGATTTCATTCAATATCTTTTTTTTAATAAACCATT
TTTACTTGGGTGTTTATA

hide sequence

RefSeq Acc Id:

XM_017003991 ⟹ XP_016859480

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	2	218,129,310 - 218,137,251 (+)	NCBI

Sequence:

show sequence

ATAGGTCACAGCTGCTCTTCTGGAGGTGTCCTACAGGTGAAAAGCCCAGCGACCCAGTCAGGAT
TTAAGTTTACCTCAAAAATGGAAGATTTTAACATGGAGAGTGACAGCTTTGAAGATTTCTGGAA
AGGTGAAGATCTTAGTAATTACAGTTACAGCTCTACCCTGCCCCCTTTTCTACTAGATGCCGCC
CCATGTGAACCAGAATCCCTGGAAATCAACAAGTATTTTGTGGTCATTATCTATGCCCTGGTAT
TCCTGCTGAGCCTGCTGGGAAACTCCCTCGTGATGCTGGTCATCTTATACAGCAGGGTCGGCCG
CTCCGTCACTGATGTCTACCTGCTGAACCTAGCCTTGGCCGACCTACTCTTTGCCCTGACCTTG
CCCATCTGGGCCGCCTCCAAGGTGAATGGCTGGATTTTTGGCACATTCCTGTGCAAGGTGGTCT
CACTCCTGAAGGAAGTCAACTTCTATAGTGGCATCCTGCTACTGGCCTGCATCAGTGTGGACCG
TTACCTGGCCATTGTCCATGCCACACGCACACTGACCCAGAAGCGCTACTTGGTCAAATTCATA
TGTCTCAGCATCTGGGGTCTGTCCTTGCTCCTGGCCCTGCCTGTCTTACTTTTCCGAAGGACCG
TCTACTCATCCAATGTTAGCCCAGCCTGCTATGAGGACATGGGCAACAATACAGCAAACTGGCG
GATGCTGTTACGGATCCTGCCCCAGTCCTTTGGCTTCATCGTGCCACTGCTGATCATGCTGTTC
TGCTACGGATTCACCCTGCGTACGCTGTTTAAGGCCCACATGGGGCAGAAGCACCGGGCCATGC
GGGTCATCTTTGCTGTCGTCCTCATCTTCCTGCTCTGCTGGCTGCCCTACAACCTGGTCCTGCT
GGCAGACACCCTCATGAGGACCCAGGTGATCCAGGAGACCTGTGAGCGCCGCAATCACATCGAC
CGGGCTCTGGATGCCACCGAGATTCTGGGCATCCTTCACAGCTGCCTCAACCCCCTCATCTACG
CCTTCATTGGCCAGAAGTTTCGCCATGGACTCCTCAAGATTCTAGCTATACATGGCTTGATCAG
CAAGGACTCCCTGCCCAAAGACAGCAGGCCTTCCTTTGTTGGCTCTTCTTCAGGGCACACTTCC
ACTACTCTCTAAGACCTCCTGCCTAAGTGCAGCCCCGTGGGGTTCCTCCCTTCTCTTCACAGTC
ACATTCCAAGCCTCATGTCCACTGGTTCTTCTTGGTCTCAGTGTCAATGCAGCCCCCATTGTGG
TCACAGGAAGTAGAGGAGGCCACGTTCTTACTAGTTTCCCTTGCATGGTTTAGAAAGCTTGCCC
TGGTGCCTCACCCCTTGCCATAATTACTATGTCATTTGCTGGAGCTCTGCCCATCCTGCCCCTG
AGCCCATGGCACTCTATGTTCTAAGAAGTGAAAATCTACACTCCAGTGAGACAGCTCTGCATAC
TCATTAGGATGGCTAGTATCAAAAGAAAGAAAATCAGGCTGGCCAACGGGGTGAAACCCTGTCT
CTACTAAAAATACAAAAAAAAAAAAAAATTAGCCGGGCGTGGTGGTGAGTGCCTGTAATCACAG
CTACTTGGGAGGCTGAGATGGGAGAATCACTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCCGA
GATTGTGCCCCTGCACTCCAGCCTGAGCGACAGTGAGACTCTGTCTCAGTCCATGAAGATGTAG
AGGAGAAACTGGAACTCTCGAGCGTTGCTGGGGGGGATTGTAAAATGGTGTGACCACTGCAGAA
GACAGTATGGCAGCTTTCCTCAAAACTTCAGACATAGAATTAACACATGATCCTGCAATTCCAC
TTATAGGAATTGACCCACAAGAAATGAAAGCAGGGACTTGAACCCATATTTGTACACCAATATT
CATAGCAGCTTATTCACAAGACCCAAAAGGCAGAAGCAACCCAAATGTTCATCAATGAATGAAT
GAATGGCTAAGCAAAATGTGATATGTACCTAACGAAGTATCCTTCAGCCTGAAAGAGGAATGAA
GTACTCATACATGTTACAACACGGACGAACCTTGAAAACTTTATGCTAAGTGAAATAAGCCAGA
CATCAACAGATAAATAGTTTATGATTCCACCTACATGAGGTACTGAGAGTGAACAAATTTACAG
AGACAGAAAGCAGAACAGTGATTACCAGGGACTGAGGGGAGGGGAGCATGGGAAGTGACGGTTT
AATGGGCACAGGGTTTATGTTTAGGATGTTGAAAAAGTTCTGCAGATAAACAGTAGTGATAGTT
GTACCGCAATGTGACTTAATGCCACTAAATTGACACTTAAAAATGGTTTAAATGGTCAATTTTG
TTATGTATATTTTATATCAATTTAAAAAAAAACCTGAGCCCCAAAAGGTATTTTAATCACCAAG
GCTGATTAAACCAAGGCTAGAACCACCTGCCTATATTTTTTGTTAAATGATTTCATTCAATATC
TTTTTTTTAATAAACCATTTTTACTTGGGTGTTTATA

hide sequence

RefSeq Acc Id:

XM_047444187 ⟹ XP_047300143

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	2	218,125,677 - 218,137,251 (+)	NCBI

RefSeq Acc Id:

XM_047444188 ⟹ XP_047300144

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	2	218,126,028 - 218,137,251 (+)	NCBI

RefSeq Acc Id:

XM_047444189 ⟹ XP_047300145

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	2	218,125,677 - 218,137,251 (+)	NCBI

RefSeq Acc Id:

XM_047444190 ⟹ XP_047300146

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	2	218,125,294 - 218,137,251 (+)	NCBI

RefSeq Acc Id:

XM_047444191 ⟹ XP_047300147

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	2	218,125,677 - 218,137,251 (+)	NCBI

RefSeq Acc Id:

XM_054341821 ⟹ XP_054197796

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
T2T-CHM13v2.0	2	218,611,395 - 218,622,946 (+)	NCBI

RefSeq Acc Id:

XM_054341822 ⟹ XP_054197797

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
T2T-CHM13v2.0	2	218,615,005 - 218,622,946 (+)	NCBI

RefSeq Acc Id:

XM_054341823 ⟹ XP_054197798

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
T2T-CHM13v2.0	2	218,611,393 - 218,622,946 (+)	NCBI

RefSeq Acc Id:

XM_054341824 ⟹ XP_054197799

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
T2T-CHM13v2.0	2	218,611,393 - 218,622,946 (+)	NCBI

RefSeq Acc Id:

XM_054341825 ⟹ XP_054197800

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
T2T-CHM13v2.0	2	218,610,987 - 218,622,946 (+)	NCBI

RefSeq Acc Id:

XM_054341826 ⟹ XP_054197801

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
T2T-CHM13v2.0	2	218,611,411 - 218,622,946 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001161770	(Get FASTA)	NCBI Sequence Viewer
	NP_001548	(Get FASTA)	NCBI Sequence Viewer
	XP_005246587	(Get FASTA)	NCBI Sequence Viewer
	XP_016859480	(Get FASTA)	NCBI Sequence Viewer
	XP_047300143	(Get FASTA)	NCBI Sequence Viewer
	XP_047300144	(Get FASTA)	NCBI Sequence Viewer
	XP_047300145	(Get FASTA)	NCBI Sequence Viewer
	XP_047300146	(Get FASTA)	NCBI Sequence Viewer
	XP_047300147	(Get FASTA)	NCBI Sequence Viewer
	XP_054197796	(Get FASTA)	NCBI Sequence Viewer
	XP_054197797	(Get FASTA)	NCBI Sequence Viewer
	XP_054197798	(Get FASTA)	NCBI Sequence Viewer
	XP_054197799	(Get FASTA)	NCBI Sequence Viewer
	XP_054197800	(Get FASTA)	NCBI Sequence Viewer
	XP_054197801	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA36108	(Get FASTA)	NCBI Sequence Viewer
	AAA64380	(Get FASTA)	NCBI Sequence Viewer
	AAA64381	(Get FASTA)	NCBI Sequence Viewer
	AAA64382	(Get FASTA)	NCBI Sequence Viewer
	AAA64383	(Get FASTA)	NCBI Sequence Viewer
	AAA64384	(Get FASTA)	NCBI Sequence Viewer
	AAA64385	(Get FASTA)	NCBI Sequence Viewer
	AAA64386	(Get FASTA)	NCBI Sequence Viewer
	AAA83148	(Get FASTA)	NCBI Sequence Viewer
	AAB59437	(Get FASTA)	NCBI Sequence Viewer
	AAC14460	(Get FASTA)	NCBI Sequence Viewer
	AAH37961	(Get FASTA)	NCBI Sequence Viewer
	AAT97985	(Get FASTA)	NCBI Sequence Viewer
	AAY24026	(Get FASTA)	NCBI Sequence Viewer
	BAA92295	(Get FASTA)	NCBI Sequence Viewer
	BAA92296	(Get FASTA)	NCBI Sequence Viewer
	BAF83595	(Get FASTA)	NCBI Sequence Viewer
	BAG35546	(Get FASTA)	NCBI Sequence Viewer
	CBX54347	(Get FASTA)	NCBI Sequence Viewer
	EAW70589	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000319635
	ENSP00000319635.2
	ENSP00000392348.1
	ENSP00000392698.1
	ENSP00000410506.1
	ENSP00000413686.1
	ENSP00000415148.1
	ENSP00000416815.1
GenBank Protein	P25025	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001161770 ⟸ NM_001168298

- UniProtKB:

Q9P2T6 (UniProtKB/Swiss-Prot), Q8IUZ1 (UniProtKB/Swiss-Prot), Q9P2T7 (UniProtKB/Swiss-Prot), P25025 (UniProtKB/Swiss-Prot), Q53PC4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLL
GNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEV
NFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNV
SPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAV
VLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQK
FRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL

hide sequence

RefSeq Acc Id:

NP_001548 ⟸ NM_001557

- UniProtKB:

Q9P2T6 (UniProtKB/Swiss-Prot), Q8IUZ1 (UniProtKB/Swiss-Prot), Q9P2T7 (UniProtKB/Swiss-Prot), P25025 (UniProtKB/Swiss-Prot), Q53PC4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLL
GNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEV
NFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNV
SPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAV
VLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQK
FRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL

hide sequence

RefSeq Acc Id:	XP_005246587 ⟸ XM_005246530
- Peptide Label:	isoform X1
- UniProtKB:	Q9P2T6 (UniProtKB/Swiss-Prot), Q8IUZ1 (UniProtKB/Swiss-Prot), Q9P2T7 (UniProtKB/Swiss-Prot), P25025 (UniProtKB/Swiss-Prot), Q53PC4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLL GNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEV NFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNV SPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAV VLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQK FRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL hide sequence

RefSeq Acc Id:	XP_016859480 ⟸ XM_017003991
- Peptide Label:	isoform X1
- UniProtKB:	Q9P2T6 (UniProtKB/Swiss-Prot), Q8IUZ1 (UniProtKB/Swiss-Prot), Q9P2T7 (UniProtKB/Swiss-Prot), P25025 (UniProtKB/Swiss-Prot), Q53PC4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLL GNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEV NFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNV SPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAV VLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQK FRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL hide sequence

Ensembl Acc Id:

ENSP00000392698 ⟸ ENST00000428565

Ensembl Acc Id:

ENSP00000413686 ⟸ ENST00000453237

Ensembl Acc Id:

ENSP00000415148 ⟸ ENST00000454148

Ensembl Acc Id:

ENSP00000392348 ⟸ ENST00000415392

Ensembl Acc Id:

ENSP00000416815 ⟸ ENST00000418878

Ensembl Acc Id:

ENSP00000410506 ⟸ ENST00000449014

Ensembl Acc Id:

ENSP00000319635 ⟸ ENST00000318507

RefSeq Acc Id:	XP_047300146 ⟸ XM_047444190
- Peptide Label:	isoform X1
- UniProtKB:	Q9P2T6 (UniProtKB/Swiss-Prot), Q8IUZ1 (UniProtKB/Swiss-Prot), P25025 (UniProtKB/Swiss-Prot), Q9P2T7 (UniProtKB/Swiss-Prot), Q53PC4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_047300145 ⟸ XM_047444189
- Peptide Label:	isoform X1
- UniProtKB:	Q9P2T6 (UniProtKB/Swiss-Prot), Q8IUZ1 (UniProtKB/Swiss-Prot), P25025 (UniProtKB/Swiss-Prot), Q9P2T7 (UniProtKB/Swiss-Prot), Q53PC4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_047300143 ⟸ XM_047444187
- Peptide Label:	isoform X1
- UniProtKB:	Q9P2T6 (UniProtKB/Swiss-Prot), Q8IUZ1 (UniProtKB/Swiss-Prot), P25025 (UniProtKB/Swiss-Prot), Q9P2T7 (UniProtKB/Swiss-Prot), Q53PC4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_047300147 ⟸ XM_047444191
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_047300144 ⟸ XM_047444188
- Peptide Label:	isoform X1
- UniProtKB:	Q9P2T6 (UniProtKB/Swiss-Prot), Q8IUZ1 (UniProtKB/Swiss-Prot), P25025 (UniProtKB/Swiss-Prot), Q9P2T7 (UniProtKB/Swiss-Prot), Q53PC4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_054197800 ⟸ XM_054341825
- Peptide Label:	isoform X1
- UniProtKB:	Q9P2T6 (UniProtKB/Swiss-Prot), Q8IUZ1 (UniProtKB/Swiss-Prot), P25025 (UniProtKB/Swiss-Prot), Q9P2T7 (UniProtKB/Swiss-Prot), Q53PC4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_054197798 ⟸ XM_054341823
- Peptide Label:	isoform X1
- UniProtKB:	Q9P2T6 (UniProtKB/Swiss-Prot), Q8IUZ1 (UniProtKB/Swiss-Prot), P25025 (UniProtKB/Swiss-Prot), Q9P2T7 (UniProtKB/Swiss-Prot), Q53PC4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_054197799 ⟸ XM_054341824
- Peptide Label:	isoform X1
- UniProtKB:	Q9P2T6 (UniProtKB/Swiss-Prot), Q8IUZ1 (UniProtKB/Swiss-Prot), P25025 (UniProtKB/Swiss-Prot), Q9P2T7 (UniProtKB/Swiss-Prot), Q53PC4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_054197796 ⟸ XM_054341821
- Peptide Label:	isoform X1
- UniProtKB:	Q9P2T6 (UniProtKB/Swiss-Prot), Q8IUZ1 (UniProtKB/Swiss-Prot), P25025 (UniProtKB/Swiss-Prot), Q9P2T7 (UniProtKB/Swiss-Prot), Q53PC4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_054197801 ⟸ XM_054341826
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_054197797 ⟸ XM_054341822
- Peptide Label:	isoform X1
- UniProtKB:	Q9P2T6 (UniProtKB/Swiss-Prot), Q8IUZ1 (UniProtKB/Swiss-Prot), P25025 (UniProtKB/Swiss-Prot), Q9P2T7 (UniProtKB/Swiss-Prot), Q53PC4 (UniProtKB/TrEMBL)

Protein Domains

G-protein coupled receptors family 1 profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P25025-F1-model_v2	AlphaFold	P25025	1-360	view protein structure

Promoters

RGD ID:

6862774

Promoter ID:

EPDNEW_H4552

Type:

initiation region

Name:

CXCR2_4

Description:

C-X-C motif chemokine receptor 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H4553 EPDNEW_H4554 EPDNEW_H4555

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	2	218,125,294 - 218,125,354	EPDNEW

RGD ID:

6862776

Promoter ID:

EPDNEW_H4553

Type:

initiation region

Name:

CXCR2_3

Description:

C-X-C motif chemokine receptor 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H4552 EPDNEW_H4554 EPDNEW_H4555

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	2	218,125,718 - 218,125,778	EPDNEW

RGD ID:

6862778

Promoter ID:

EPDNEW_H4554

Type:

initiation region

Name:

CXCR2_1

Description:

C-X-C motif chemokine receptor 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H4552 EPDNEW_H4553 EPDNEW_H4555

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	2	218,126,028 - 218,126,088	EPDNEW

RGD ID:

6862780

Promoter ID:

EPDNEW_H4555

Type:

initiation region

Name:

CXCR2_2

Description:

C-X-C motif chemokine receptor 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H4552 EPDNEW_H4553 EPDNEW_H4554

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	2	218,129,317 - 218,129,377	EPDNEW

RGD ID:

6797657

Promoter ID:

HG_KWN:37191

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

Lymphoblastoid, NB4

Transcripts:

OTTHUMT00000256772, OTTHUMT00000338837, OTTHUMT00000338841, UC002VGZ.1, UC002VHB.1

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	2	218,698,581 - 218,699,081 (+)	MPROMDB

RGD ID:

6850200

Promoter ID:

EP57007

Type:

initiation region

Name:

HS_IL8RB

Description:

Interleukin-8 receptor B (IL-8R B), member of the G-protein-coupledrhodopsin superfamily of receptors, IL8RB or CXCR2 gene.

SO ACC ID:

SO:0000170

Source:

EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Tissues & Cell Lines:

neutrophil

Experiment Methods:

Sequencing of a full-length cDNA

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	2	218,699,020 - 218,699,080	EPD

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:6027	AgrOrtholog
COSMIC	CXCR2	COSMIC
Ensembl Genes	ENSG00000180871	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENST00000318507	ENTREZGENE
	ENST00000318507.7	UniProtKB/Swiss-Prot
	ENST00000415392.5	UniProtKB/TrEMBL
	ENST00000418878.1	UniProtKB/TrEMBL
	ENST00000428565.1	UniProtKB/TrEMBL
	ENST00000449014.5	UniProtKB/TrEMBL
	ENST00000453237.5	UniProtKB/TrEMBL
	ENST00000454148.1	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx	ENSG00000180871	GTEx
HGNC ID	HGNC:6027	ENTREZGENE
Human Proteome Map	CXCR2	Human Proteome Map
InterPro	Chemokine_CXCR2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Chemokine_CXCR_1/2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_Rhodpsn	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	hsa:3579	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	3579	ENTREZGENE
OMIM	146928	OMIM
PANTHER	C-X-C CHEMOKINE RECEPTOR TYPE 2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CELL ADHESION MOLECULE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	PA29843	PharmGKB
PRINTS	GPCRRHODOPSN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	INTRLEUKIN8R	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	INTRLEUKN8BR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	C9J1J7_HUMAN	UniProtKB/TrEMBL
	C9J2F9_HUMAN	UniProtKB/TrEMBL
	C9JG19_HUMAN	UniProtKB/TrEMBL
	C9JW47_HUMAN	UniProtKB/TrEMBL
	CXCR2_HUMAN	UniProtKB/Swiss-Prot, ENTREZGENE
	Q53PC4	ENTREZGENE, UniProtKB/TrEMBL
	Q6LCZ7_HUMAN	UniProtKB/TrEMBL
	Q8IUZ1	ENTREZGENE
	Q9P2T6	ENTREZGENE
	Q9P2T7	ENTREZGENE
UniProt Secondary	Q8IUZ1	UniProtKB/Swiss-Prot
	Q9P2T6	UniProtKB/Swiss-Prot
	Q9P2T7	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-21	CXCR2	C-X-C motif chemokine receptor 2	CXCR2	chemokine (C-X-C motif) receptor 2	Symbol and/or name change	5135510	APPROVED
2011-07-27	CXCR2	chemokine (C-X-C motif) receptor 2	IL8RB	interleukin 8 receptor, beta	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

Manual Human Phenotype Annotations - RGD

Imported Human Phenotype Annotations - HPO

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

Manual Human Phenotype Annotations - RGD

Imported Human Phenotype Annotations - HPO