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Gene: RET (ret proto-oncogene) Homo sapiens

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Symbol:

RET

Name:

ret proto-oncogene

RGD ID:

735296

HGNC Page

HGNC:9967

Description:

Enables calcium ion binding activity and transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including GDF15-GFRAL signaling pathway; neuron cell-cell adhesion; and positive regulation of signal transduction. Located in endosome membrane. Part of plasma membrane protein complex and receptor complex. Is active in plasma membrane. Implicated in several diseases, including Hirschsprung's disease; familial medullary thyroid carcinoma; multiple endocrine neoplasia type 2A; multiple endocrine neoplasia type 2B; and pheochromocytoma. Biomarker of pancreatic cancer.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

cadherin family member 12; cadherin-related family member 16; CDHF12; CDHR16; CUX1/RET fusion; HSCR1; hydroxyaryl-protein kinase; MEN2A; MEN2B; MTC1; proto-oncogene c-Ret; proto-oncogene tyrosine-protein kinase receptor Ret; PTC; rearranged during transfection; receptor tyrosine kinase; ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease); RET receptor tyrosine kinase; RET transforming sequence; RET-ELE1; RET51

RGD Orthologs

Alliance Orthologs

More Info

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More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Ret (ret proto-oncogene)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Ret (ret proto-oncogene)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Chinchilla lanigera (long-tailed chinchilla):	Ret (ret proto-oncogene)	NCBI	Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):	RET (ret proto-oncogene)	NCBI	Ortholog
Canis lupus familiaris (dog):	RET (ret proto-oncogene)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ret (ret proto-oncogene)	NCBI	Ortholog
Sus scrofa (pig):	RET (ret proto-oncogene)	HGNC	EggNOG, Ensembl, NCBI, OMA, OrthoDB, Panther, Treefam
Chlorocebus sabaeus (green monkey):	RET (ret proto-oncogene)	NCBI	Ortholog
Heterocephalus glaber (naked mole-rat):	Ret (ret proto-oncogene)	NCBI	Ortholog
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Ret (ret proto-oncogene)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ret (ret proto-oncogene)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ret (ret proto-oncogene receptor tyrosine kinase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Drosophila melanogaster (fruit fly):	Ret	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus laevis (African clawed frog):	ret.L	Alliance	DIOPT (Xenbase)
Xenopus tropicalis (tropical clawed frog):	ret	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus laevis (African clawed frog):	ret.S	Alliance	DIOPT (Xenbase)

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	43,077,069 - 43,130,351 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	43,077,064 - 43,130,351 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	43,572,517 - 43,625,799 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	42,892,523 - 42,945,805 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	42,892,532 - 42,944,955	NCBI
Celera	10	39,575,663 - 39,628,954 (+)	NCBI		Celera
Cytogenetic Map	10	q11.21	NCBI
HuRef	10	40,098,756 - 40,151,896 (+)	NCBI		HuRef
CHM1_1	10	43,611,715 - 43,665,000 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	43,954,542 - 44,007,848 (+)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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