Lyz2 (lysozyme 2) - Rat Genome Database

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Gene: Lyz2 (lysozyme 2) Mus musculus
Analyze
Symbol: Lyz2
Name: lysozyme 2
RGD ID: 735255
MGI Page MGI
Description: Enables lysozyme activity. Involved in defense response to Gram-negative bacterium and defense response to Gram-positive bacterium. Predicted to be located in several cellular components, including Golgi cis cisterna; cytoplasmic vesicle; and rough endoplasmic reticulum lumen. Is expressed in several structures, including hematopoietic system; liver; mesothelium; small intestine; and yolk sac. Human ortholog(s) of this gene implicated in familial visceral amyloidosis. Orthologous to human LYZ (lysozyme).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 1,4-beta-N-acetylmuramidase C; AI326280; L; Ly; Lys; Lysm; lysozyme C type M; lysozyme C-2; lysozyme f2; Lyzf2; Lyzs; Lz; Lzm; Lzm-; Lzm-s1; Lzp
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910117,113,446 - 117,118,177 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10117,113,236 - 117,118,226 (-)EnsemblGRCm39 Ensembl
GRCm3810117,277,541 - 117,282,272 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10117,277,331 - 117,282,321 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710116,714,597 - 116,719,328 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610116,681,443 - 116,686,374 (-)NCBIMGSCv36mm8
Celera10119,220,558 - 119,225,289 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1065.34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (ISO)
(1->4)-beta-D-glucan  (EXP)
(5Z,8Z,11Z,13E)-15-HETE  (ISO)
1,2,4-trimethylbenzene  (ISO)
1,2-dimethylhydrazine  (EXP)
1-Ethyl-2-benzimidazolinone  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,5-hexanedione  (ISO)
2-butoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
aconitine  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
ampicillin  (ISO)
antirheumatic drug  (ISO)
azathioprine  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (ISO)
buspirone  (ISO)
buta-1,3-diene  (EXP)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
captan  (EXP)
carbachol  (ISO)
carbon nanotube  (EXP)
carnosic acid  (EXP)
choline  (EXP)
cisplatin  (ISO)
cobalt atom  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cytarabine  (ISO)
deoxynivalenol  (EXP)
dexamethasone  (EXP)
dextran sulfate  (EXP)
dibutyl phthalate  (EXP)
diclofenac  (EXP)
diethylstilbestrol  (EXP)
dioxygen  (EXP)
diuron  (ISO)
dodecanoic acid  (EXP)
doxorubicin  (EXP)
endosulfan  (ISO)
ethanol  (EXP)
fenofibrate  (EXP)
ferric oxide  (EXP)
ferroheme b  (ISO)
flutamide  (ISO)
folic acid  (EXP)
folpet  (EXP)
fumonisin B1  (EXP)
furan  (ISO)
gemcitabine  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
glyburide  (ISO)
heme b  (ISO)
hydrogen peroxide  (ISO)
imidacloprid  (ISO)
irinotecan  (EXP)
L-methionine  (EXP)
lead(II) chloride  (ISO)
lipopolysaccharide  (EXP)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
metronidazole  (ISO)
milrinone  (ISO)
Muraglitazar  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
neomycin  (ISO)
nickel atom  (ISO)
nickel subsulfide  (ISO)
nimesulide  (ISO)
nitrofen  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parthenolide  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (EXP)
pifithrin-?  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 203580  (ISO)
senecionine  (EXP)
sodium arsenite  (EXP,ISO)
streptozocin  (ISO)
T-2 toxin  (ISO)
Tesaglitazar  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetradecane  (ISO)
thapsigargin  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
Tributyltin oxide  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (EXP)
triticonazole  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (EXP,ISO)
tungsten  (EXP)
Tungsten carbide  (ISO)
valproic acid  (EXP,ISO)
vanadyl sulfate  (ISO)
vancomycin  (EXP,ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal abdominal lymph node morphology  (IAGP)
abnormal actin cytoskeleton morphology  (IAGP)
abnormal aerobic respiration  (IAGP)
abnormal alveolar macrophage morphology  (IAGP)
abnormal alveolar macrophage physiology  (IAGP)
abnormal B cell number  (IAGP)
abnormal blood circulation  (IAGP)
abnormal blood homeostasis  (IAGP)
abnormal body temperature  (IAGP)
abnormal bone marrow cell morphology/development  (IAGP)
abnormal bone marrow cell number  (IAGP)
abnormal bone marrow cell physiology  (IAGP)
abnormal bone ossification  (IAGP)
abnormal capillary morphology  (IAGP)
abnormal CD4-positive, alpha-beta T cell number  (IAGP)
abnormal CD8-positive, alpha-beta T cell number  (IAGP)
abnormal cellular extravasation  (IAGP)
abnormal cellular respiration  (IAGP)
abnormal chemokine level  (IAGP)
abnormal chemokine secretion  (IAGP)
abnormal chloride level  (IAGP)
abnormal circulating chemokine level  (IAGP)
abnormal circulating cytokine level  (IAGP)
abnormal circulating protein level  (IAGP)
abnormal colon morphology  (IAGP)
abnormal common myeloid progenitor cell morphology  (IAGP)
abnormal compact bone morphology  (IAGP)
abnormal cued conditioning behavior  (IAGP)
abnormal cytokine level  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal endocytosis  (IAGP)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal enzyme/coenzyme level  (IAGP)
abnormal erythropoiesis  (IAGP)
abnormal gluconeogenesis  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal glycogen homeostasis  (IAGP)
abnormal immune cell physiology  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal inflammatory response  (IAGP)
abnormal interferon level  (IAGP)
abnormal interleukin-6 secretion  (IAGP)
abnormal intestinal goblet cell morphology  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal iron homeostasis  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal Kupffer cell morphology  (IAGP)
abnormal leukocyte physiology  (IAGP)
abnormal lipid homeostasis  (IAGP)
abnormal liver morphology  (IAGP)
abnormal lung interstitium morphology  (IAGP)
abnormal lung morphology  (IAGP)
abnormal lymphatic vessel morphology  (IAGP)
abnormal lymphocyte cell number  (IAGP)
abnormal macrophage activation involved in immune response  (IAGP)
abnormal macrophage antigen presentation  (IAGP)
abnormal macrophage chemotaxis  (IAGP)
abnormal macrophage differentiation  (IAGP)
abnormal macrophage morphology  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal megakaryocyte progenitor cell morphology  (IAGP)
abnormal metabolism  (IAGP)
abnormal MHC II cell surface expression on macrophages  (IAGP)
abnormal microglial cell activation  (IAGP)
abnormal microglial cell physiology  (IAGP)
abnormal mitochondrial physiology  (IAGP)
abnormal monocyte cell number  (IAGP)
abnormal myeloblast morphology/development  (IAGP)
abnormal myeloid cell number  (IAGP)
abnormal myelopoiesis  (IAGP)
abnormal myocardium layer morphology  (IAGP)
abnormal nephron morphology  (IAGP)
abnormal neutrophil differentiation  (IAGP)
abnormal neutrophil morphology  (IAGP)
abnormal neutrophil physiology  (IAGP)
abnormal NK cell differentiation  (IAGP)
abnormal NK cell physiology  (IAGP)
abnormal nociception after inflammation  (IAGP)
abnormal osteoclast differentiation  (IAGP)
abnormal osteoclast morphology  (IAGP)
abnormal osteoclast physiology  (IAGP)
abnormal peritoneal macrophage morphology  (IAGP)
abnormal physiological neovascularization  (IAGP)
abnormal pilomotor reflex  (IAGP)
abnormal podocyte foot process morphology  (IAGP)
abnormal pulmonary alveolus morphology  (IAGP)
abnormal redox activity  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal response to CNS ischemic injury  (IAGP)
abnormal retina blood vessel morphology  (IAGP)
abnormal skeleton development  (IAGP)
abnormal small intestine morphology  (IAGP)
abnormal spatial reference memory  (IAGP)
abnormal spleen B cell follicle morphology  (IAGP)
abnormal spleen marginal zone macrophage morphology  (IAGP)
abnormal spleen marginal zone morphology  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal spleen red pulp morphology  (IAGP)
abnormal surfactant secretion  (IAGP)
abnormal systemic arterial blood pressure  (IAGP)
abnormal thymus corticomedullary boundary morphology  (IAGP)
abnormal thymus morphology  (IAGP)
abnormal trabecular bone morphology  (IAGP)
abnormal tumor pathology  (IAGP)
abnormal tumor susceptibility  (IAGP)
abnormal vascular wound healing  (IAGP)
abnormal wound healing  (IAGP)
absent B cells  (IAGP)
absent marginal zone B cells  (IAGP)
absent T cells  (IAGP)
absent type II pneumocytes  (IAGP)
albuminuria  (IAGP)
alveolitis  (IAGP)
anemia  (IAGP)
arthritis  (IAGP)
atherosclerotic lesions  (IAGP)
cellular necrosis  (IAGP)
colitis  (IAGP)
decreased acute inflammation  (IAGP)
decreased alveolar macrophage number  (IAGP)
decreased B cell number  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased body temperature  (IAGP)
decreased body weight  (IAGP)
decreased bone marrow cell number  (IAGP)
decreased bone mineral density  (IAGP)
decreased bone ossification  (IAGP)
decreased bone resorption  (IAGP)
decreased bone trabecula number  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased cerebral infarct size  (IAGP)
decreased cholesterol level  (IAGP)
decreased circulating alanine transaminase level  (IAGP)
decreased circulating aspartate transaminase level  (IAGP)
decreased circulating free fatty acids level  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating interferon-alpha level  (IAGP)
decreased circulating interferon-beta level  (IAGP)
decreased circulating interleukin-1 beta level  (IAGP)
decreased circulating interleukin-10 level  (IAGP)
decreased circulating interleukin-6 level  (IAGP)
decreased circulating LDL cholesterol level  (IAGP)
decreased circulating tumor necrosis factor level  (IAGP)
decreased collagen level  (IAGP)
decreased common myeloid progenitor cell number  (IAGP)
decreased compact bone mass  (IAGP)
decreased compact bone thickness  (IAGP)
decreased core body temperature  (IAGP)
decreased CXCL10 level  (IAGP)
decreased cytokine level  (IAGP)
decreased erythroid progenitor cell number  (IAGP)
decreased fasting circulating glucose level  (IAGP)
decreased fat cell size  (IAGP)
decreased fatty acids level  (IAGP)
decreased granulocyte number  (IAGP)
decreased hematocrit  (IAGP)
decreased hemoglobin content  (IAGP)
decreased incidence of tumors by chemical induction  (IAGP)
decreased inflammatory response  (IAGP)
decreased interferon-beta secretion  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased interleukin-1 alpha secretion  (IAGP)
decreased interleukin-1 beta secretion  (IAGP)
decreased interleukin-10 secretion  (IAGP)
decreased interleukin-12 secretion  (IAGP)
decreased interleukin-4 secretion  (IAGP)
decreased interleukin-6 secretion  (IAGP)
decreased lean body mass  (IAGP)
decreased leukocyte cell number  (IAGP)
decreased locomotor activity  (IAGP)
decreased Ly6C low monocyte number  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased macrophage cell number  (IAGP)
decreased macrophage cytokine production  (IAGP)
decreased mechanical nociceptive threshold  (IAGP)
decreased memory T cell number  (IAGP)
decreased metastatic potential  (IAGP)
decreased neuron number  (IAGP)
decreased neutrophil cell number  (IAGP)
decreased NK cell number  (IAGP)
decreased osteoclast cell number  (IAGP)
decreased pancreatic beta cell proliferation  (IAGP)
decreased prostaglandin level  (IAGP)
decreased regulatory T cell number  (IAGP)
decreased spleen iron level  (IAGP)
decreased susceptibility to autoimmune disorder  (IAGP)
decreased susceptibility to bacterial infection  (IAGP)
decreased susceptibility to bacterial infection induced morbidity/mortality  (IAGP)
decreased susceptibility to diet-induced hepatic steatosis  (IAGP)
decreased susceptibility to diet-induced obesity  (IAGP)
decreased susceptibility to endotoxin shock  (IAGP)
decreased susceptibility to induced arthritis  (IAGP)
decreased susceptibility to induced colitis  (IAGP)
decreased susceptibility to induced morbidity/mortality  (IAGP)
decreased susceptibility to injury  (IAGP)
decreased susceptibility to ischemic brain injury  (IAGP)
decreased susceptibility to neuronal excitotoxicity  (IAGP)
decreased susceptibility to Paramyxoviridae infection  (IAGP)
decreased susceptibility to parasitic infection  (IAGP)
decreased susceptibility to viral infection  (IAGP)
decreased susceptibility to weight gain  (IAGP)
decreased susceptibility to xenobiotic induced morbidity/mortality  (IAGP)
decreased thermal nociceptive threshold  (IAGP)
decreased trabecular bone mass  (IAGP)
decreased trabecular bone volume  (IAGP)
decreased transforming growth factor beta level  (IAGP)
decreased triglyceride level  (IAGP)
decreased tumor growth/size  (IAGP)
decreased tumor necrosis factor secretion  (IAGP)
delayed wound healing  (IAGP)
diarrhea  (IAGP)
enlarged kidney  (IAGP)
enlarged liver  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
expanded mesangial matrix  (IAGP)
extramedullary hematopoiesis  (IAGP)
focal hepatic necrosis  (IAGP)
fused podocyte foot processes  (IAGP)
glomerulonephritis  (IAGP)
granulomatous inflammation  (IAGP)
hairless  (IAGP)
hepatic necrosis  (IAGP)
hunched posture  (IAGP)
impaired autophagy  (IAGP)
impaired complement alternative pathway  (IAGP)
impaired glucose tolerance  (IAGP)
impaired granulocyte bactericidal activity  (IAGP)
impaired macrophage chemotaxis  (IAGP)
impaired macrophage phagocytosis  (IAGP)
impaired neutrophil chemotaxis  (IAGP)
impaired neutrophil recruitment  (IAGP)
improved glucose tolerance  (IAGP)
increased acute promyelocytic leukemia incidence  (IAGP)
increased anti-double stranded DNA antibody level  (IAGP)
increased anti-nuclear antigen antibody level  (IAGP)
increased anti-single stranded DNA antibody level  (IAGP)
increased apoptosis  (IAGP)
increased autoantibody level  (IAGP)
increased B cell number  (IAGP)
increased blood urea nitrogen level  (IAGP)
increased bone mass  (IAGP)
increased bone mineral density  (IAGP)
increased bone resorption  (IAGP)
increased bone trabecular spacing  (IAGP)
increased bone volume  (IAGP)
increased brain size  (IAGP)
increased CD4-positive, alpha-beta T cell number  (IAGP)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased cellular sensitivity to hydrogen peroxide  (IAGP)
increased cellular sensitivity to oxidative stress  (IAGP)
increased circulating alanine transaminase level  (IAGP)
increased circulating aspartate transaminase level  (IAGP)
increased circulating creatine level  (IAGP)
increased circulating creatinine level  (IAGP)
increased circulating CXCL10 level  (IAGP)
increased circulating HDL cholesterol level  (IAGP)
increased circulating interferon-beta level  (IAGP)
increased circulating interferon-gamma level  (IAGP)
increased circulating interleukin-1 alpha level  (IAGP)
increased circulating interleukin-1 beta level  (IAGP)
increased circulating interleukin-10 level  (IAGP)
increased circulating interleukin-12 level  (IAGP)
increased circulating interleukin-12b level  (IAGP)
increased circulating interleukin-17 level  (IAGP)
increased circulating interleukin-18 level  (IAGP)
increased circulating interleukin-2 level  (IAGP)
increased circulating interleukin-6 level  (IAGP)
increased circulating iron level  (IAGP)
increased circulating lactate dehydrogenase level  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased colon adenocarcinoma incidence  (IAGP)
increased colon adenoma incidence  (IAGP)
increased dendritic cell number  (IAGP)
increased effector memory CD8-positive, alpha-beta T cell number  (IAGP)
increased energy expenditure  (IAGP)
increased eosinophil cell number  (IAGP)
increased epididymal fat pad weight  (IAGP)
increased granulocyte number  (IAGP)
increased hematopoietic stem cell number  (IAGP)
increased IgG level  (IAGP)
increased IgM level  (IAGP)
increased immature B cell number  (IAGP)
increased incidence of tumors by chemical induction  (IAGP)
increased inflammatory response  (IAGP)
increased insulin secretion  (IAGP)
increased insulin sensitivity  (IAGP)
increased interferon-beta secretion  (IAGP)
increased interferon-gamma secretion  (IAGP)
increased interleukin-1 beta secretion  (IAGP)
increased interleukin-10 secretion  (IAGP)
increased interleukin-12 secretion  (IAGP)
increased interleukin-12b secretion  (IAGP)
increased interleukin-13 secretion  (IAGP)
increased interleukin-17 secretion  (IAGP)
increased interleukin-18 secretion  (IAGP)
increased interleukin-23 secretion  (IAGP)
increased interleukin-4 secretion  (IAGP)
increased interleukin-6 secretion  (IAGP)
increased kidney weight  (IAGP)
increased leukemia incidence  (IAGP)
increased leukocyte cell number  (IAGP)
increased lung adenocarcinoma incidence  (IAGP)
increased lung adenoma incidence  (IAGP)
increased lung tumor incidence  (IAGP)
increased lung weight  (IAGP)
increased lymphocyte cell number  (IAGP)
increased macrophage apoptosis  (IAGP)
increased macrophage cell number  (IAGP)
increased marginal zone B cell number  (IAGP)
increased mean systemic arterial blood pressure  (IAGP)
increased mesangial cell number  (IAGP)
increased microglial cell activation  (IAGP)
increased monocyte cell number  (IAGP)
increased neutrophil cell number  (IAGP)
increased osteoclast cell number  (IAGP)
increased prostaglandin level  (IAGP)
increased renal glomerulus apoptosis  (IAGP)
increased renal glomerulus basement membrane thickness  (IAGP)
increased sensitivity to induced cell death  (IAGP)
increased spleen weight  (IAGP)
increased splenocyte proliferation  (IAGP)
increased susceptibility to atherosclerosis  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to bacterial infection induced morbidity/mortality  (IAGP)
increased susceptibility to endotoxin shock  (IAGP)
increased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
increased susceptibility to fungal infection  (IAGP)
increased susceptibility to Herpesvirales infection  (IAGP)
increased susceptibility to Herpesvirales infection induced morbidity/mortality  (IAGP)
increased susceptibility to induced arthritis  (IAGP)
increased susceptibility to induced colitis  (IAGP)
increased susceptibility to induced morbidity/mortality  (IAGP)
increased susceptibility to injury  (IAGP)
increased susceptibility to parasitic infection  (IAGP)
increased susceptibility to Retroviridae infection  (IAGP)
increased susceptibility to Riboviria infection  (IAGP)
increased susceptibility to Riboviria infection induced morbidity/mortality  (IAGP)
increased susceptibility to systemic lupus erythematosus  (IAGP)
increased susceptibility to type I hypersensitivity reaction  (IAGP)
increased susceptibility to weight loss  (IAGP)
increased susceptibility to xenobiotic induced morbidity/mortality  (IAGP)
increased T cell number  (IAGP)
increased T cell proliferation  (IAGP)
increased trabecular bone volume  (IAGP)
increased tumor growth/size  (IAGP)
increased tumor necrosis factor secretion  (IAGP)
increased urine protein level  (IAGP)
increased vascular permeability  (IAGP)
insulin resistance  (IAGP)
joint inflammation  (IAGP)
joint swelling  (IAGP)
lethargy  (IAGP)
liver fibrosis  (IAGP)
liver inflammation  (IAGP)
lung hemorrhage  (IAGP)
lung inflammation  (IAGP)
myeloid hyperplasia  (IAGP)
no abnormal phenotype detected  (IAGP)
osteopetrosis  (IAGP)
osteoporosis  (IAGP)
oxidative stress  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
peritoneal inflammation  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
pulmonary edema  (IAGP)
pulmonary parenchymal consolidation  (IAGP)
reddish skin  (IAGP)
renal glomerulus hypertrophy  (IAGP)
renal tubular necrosis  (IAGP)
respiratory distress  (IAGP)
respiratory failure  (IAGP)
ruffled hair  (IAGP)
scaly skin  (IAGP)
skin inflammation  (IAGP)
slow postnatal weight gain  (IAGP)
small intestinal inflammation  (IAGP)
small pancreatic islets  (IAGP)
tachypnea  (IAGP)
thrombocytosis  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Differentiation of the mononuclear phagocyte system during mouse embryogenesis: the role of transcription factor PU.1. Lichanska AM, etal., Blood 1999 Jul 1;94(1):127-38.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, etal., Cell 2003 Nov 26;115(5):629-40.
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. Human lysozyme gene mutations cause hereditary systemic amyloidosis. Pepys MB, etal., Nature. 1993 Apr 8;362(6420):553-7.
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. A novel lysozyme mutation Phe57Ile associated with hereditary renal amyloidosis. Yazaki M, etal., Kidney Int. 2003 May;63(5):1652-7.
Additional References at PubMed
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PMID:19838202   PMID:19863805   PMID:19907077   PMID:19913445   PMID:19926832   PMID:19929439   PMID:19932746   PMID:19933310   PMID:19941312   PMID:19951693   PMID:20041412   PMID:20053716  
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PMID:20185763   PMID:20194441   PMID:20226692   PMID:20231695   PMID:20299514   PMID:20308544   PMID:20362473   PMID:20363918   PMID:20404134   PMID:20407037   PMID:20410508   PMID:20421389  
PMID:20435883   PMID:20457873   PMID:20472897   PMID:20479009   PMID:20483735   PMID:20498053   PMID:20498354   PMID:20505137   PMID:20516367   PMID:20516641   PMID:20519121   PMID:20519123  
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PMID:20697155   PMID:20724542   PMID:20733032   PMID:20739676   PMID:20821729   PMID:20826430   PMID:20841473   PMID:20884649   PMID:20941861   PMID:20947763   PMID:20952691   PMID:20956207  
PMID:20978081   PMID:20980680   PMID:21029863   PMID:21030556   PMID:21041726   PMID:21051439   PMID:21068720   PMID:21070799   PMID:21072211   PMID:21084629   PMID:21084708   PMID:21088048  
PMID:21093321   PMID:21099114   PMID:21119595   PMID:21135166   PMID:21151480   PMID:21156970   PMID:21173151   PMID:21191403   PMID:21216972   PMID:21217818   PMID:21224471   PMID:21242513  
PMID:21245373   PMID:21245915   PMID:21266780   PMID:21267068   PMID:21278352   PMID:21283724   PMID:21308776   PMID:21349431   PMID:21361875   PMID:21364283   PMID:21408140   PMID:21411758  
PMID:21458307   PMID:21464320   PMID:21467220   PMID:21469085   PMID:21480213   PMID:21490276   PMID:21494554   PMID:21507897   PMID:21508962   PMID:21533069   PMID:21553074   PMID:21565532  
PMID:21571064   PMID:21602809   PMID:21606371   PMID:21622562   PMID:21624767   PMID:21646388   PMID:21670502   PMID:21695272   PMID:21705499   PMID:21706006   PMID:21765015   PMID:21768286  
PMID:21775420   PMID:21778228   PMID:21799073   PMID:21799178   PMID:21805465   PMID:21810607   PMID:21841315   PMID:21841782   PMID:21873454   PMID:21873635   PMID:21875910   PMID:21876000  
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