Rbp4 (retinol binding protein 4, plasma) - Rat Genome Database

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Gene: Rbp4 (retinol binding protein 4, plasma) Mus musculus
Analyze
Symbol: Rbp4
Name: retinol binding protein 4, plasma
RGD ID: 735252
MGI Page MGI
Description: Enables molecular carrier activity and retinol binding activity. Involved in several processes, including embryonic morphogenesis; heart development; and reproductive structure development. Acts upstream of or within several processes, including detection of light stimulus involved in visual perception; retinoid metabolic process; and terpenoid transport. Located in extracellular space. Is active in extracellular region. Is expressed in several structures, including adipose tissue; brain; genitourinary system; gut; and hindlimb. Human ortholog(s) of this gene implicated in coronary artery disease and type 2 diabetes mellitus. Orthologous to human RBP4 (retinol binding protein 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: plasma retinol-binding protein; PRBP; RBP; Rbp-4; retinol binding protein 4, cellular; retinol-binding protein 4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391938,105,068 - 38,113,769 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1938,105,077 - 38,113,729 (-)EnsemblGRCm39 Ensembl
GRCm381938,116,620 - 38,125,321 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1938,116,629 - 38,125,281 (-)EnsemblGRCm38mm10GRCm38
MGSCv371938,191,110 - 38,199,811 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361938,181,773 - 38,190,392 (-)NCBIMGSCv36mm8
Celera1938,908,311 - 38,919,212 (-)NCBICelera
Cytogenetic Map19C2NCBI
cM Map1932.75NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Coronary Syndrome  (ISO)
acute pyelonephritis  (ISO)
Alcoholic Liver Diseases  (ISO)
Animal Mammary Neoplasms  (ISO)
Anophthalmia  (ISO)
anterior segment dysgenesis  (ISO)
aortic disease  (IMP)
Arteriovenous Fistula  (ISO)
atherosclerosis  (IMP,ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
Cardiomegaly  (IMP)
Carotid Atherosclerosis  (ISO)
cerebral infarction  (ISO)
chronic kidney disease  (ISO)
coloboma  (ISO)
colon adenoma  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
dilated cardiomyopathy  (ISO)
Dyslipidemias  (ISO)
essential hypertension  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
Eye Abnormalities  (ISO)
familial hypercholesterolemia  (ISO)
familial temporal lobe epilepsy 1  (ISO)
fundus dystrophy  (ISO)
gallbladder cancer  (ISO)
genetic disease  (ISO)
gestational diabetes  (ISO)
hyperinsulinism  (ISO)
hypertension  (IMP,ISO)
Hypertriglyceridemia  (ISO)
Insulin Resistance  (ISO)
Jaundice  (ISO)
keratomalacia  (ISO)
kidney disease  (ISO)
liver cirrhosis  (ISO)
Metabolic Syndrome  (ISO)
microphthalmia  (ISO)
Microphthalmia/Coloboma 10  (ISO)
myocardial infarction  (ISO)
Necrosis  (ISO)
obesity  (IEP,ISO)
Pediatric Obesity  (ISO)
polycystic ovary syndrome  (ISO)
pre-eclampsia  (ISO)
Pregnancy-Induced Hypertension  (ISO)
Prehypertension  (ISO)
proliferative diabetic retinopathy  (ISO)
psoriasis  (ISO)
Retinal Dystrophy, Iris Coloboma, and Comedogenic Acne Syndrome  (ISO)
severe pre-eclampsia  (ISO)
Spontaneous Abortions  (ISO)
Stable Angina  (ISO)
Stomach Neoplasms  (ISO)
systemic scleroderma  (ISO)
type 2 diabetes mellitus  (ISO)
Vision Disorders  (ISO)
Vitamin A Deficiency  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(1->4)-beta-D-glucan  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-dihydrocoumarin  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
aconitine  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP,ISO)
allopurinol  (ISO)
alpha-Zearalanol  (ISO)
ammonium chloride  (ISO)
Ampullosporin  (ISO)
aniline  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (EXP,ISO)
berberine  (ISO)
beta-carotene  (EXP,ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A5  (ISO)
buta-1,3-diene  (EXP)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calciol  (EXP)
carbon nanotube  (EXP)
chlorpyrifos  (ISO)
choline  (EXP)
chrysin  (EXP)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
dibenzofuran  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
diuron  (ISO)
doxorubicin  (EXP)
folic acid  (EXP)
fonofos  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glucose  (ISO)
glycogen  (ISO)
GW 4064  (EXP)
hydrazine  (EXP)
indometacin  (ISO)
isoscutellarein  (EXP)
kaempferol  (EXP)
ketamine  (ISO)
L-methionine  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
metformin  (ISO)
methimazole  (ISO)
methylmercury chloride  (ISO)
mifepristone  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (EXP)
N-methyl-N-nitrosourea  (ISO)
nitrofen  (ISO)
norwogonin  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (ISO)
parathion  (ISO)
perfluorododecanoic acid  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
pirinixic acid  (EXP)
potassium dichromate  (EXP)
progesterone  (EXP,ISO)
quercetin  (EXP,ISO)
resveratrol  (EXP,ISO)
retinyl acetate  (EXP)
rimonabant  (EXP)
rotenone  (EXP)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (EXP,ISO)
streptozocin  (ISO)
sulfadimethoxine  (ISO)
sulfasalazine  (EXP)
tamoxifen  (EXP)
terbufos  (ISO)
tert-butyl ethyl ether  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
Triptolide  (ISO)
valproic acid  (EXP,ISO)
valsartan  (ISO)
vinclozolin  (ISO)
wogonin  (EXP)
zinc oxide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Serum levels of retinol-binding protein 4 and risk of colon adenoma. Abola MV, etal., Endocr Relat Cancer. 2015 Apr;22(2):L1-4. doi: 10.1530/ERC-14-0429.
2. Serum retinol binding protein 4 level is related with renal functions in Type 2 diabetes. Akbay E, etal., J Endocrinol Invest. 2010 Nov;33(10):725-9. doi: 10.1007/BF03346678. Epub 2010 Apr 30.
3. Evaluation of irisin, retinol-binding protein 4, and leptin serum levels as biomarkers of macrovascular complications involvement in Saudi type 2 diabetes mellitus. A case-control study. Ali EY, etal., Saudi Med J. 2020 Dec;41(12):1369-1374. doi: 10.15537/smj.2020.12.25461.
4. Signaling by vitamin A and retinol-binding protein in regulation of insulin responses and lipid homeostasis. Berry DC and Noy N, Biochim Biophys Acta. 2012 Jan;1821(1):168-76. Epub 2011 Jul 12.
5. Increased plasma retinol binding protein 4 levels in patients with inflammatory cardiomyopathy. Bobbert P, etal., Eur J Heart Fail. 2009 Dec;11(12):1163-8. doi: 10.1093/eurjhf/hfp153.
6. Retinol-binding protein 4 as a plasma biomarker of renal dysfunction and cardiovascular disease in type 2 diabetes. Cabré A, etal., J Intern Med. 2007 Oct;262(4):496-503. doi: 10.1111/j.1365-2796.2007.01849.x.
7. Elevated serum retinol-binding protein 4 concentrations are associated with renal dysfunction and uric acid in type 2 diabetic patients. Chang YH, etal., Diabetes Metab Res Rev. 2008 Nov-Dec;24(8):629-34. doi: 10.1002/dmrr.894.
8. Increased levels of retinol binding protein 4 in patients with advanced heart failure correct after hemodynamic improvement through ventricular assist device placement. Chavarria N, etal., Circ J. 2012;76(9):2148-52. doi: 10.1253/circj.cj-12-0350. Epub 2012 Jun 12.
9. Serum retinol binding protein 4 and clinical outcome in postoperative biliary atresia. Chayanupatkul M, etal., Hepatol Int. 2011 Dec;5(4):906-12. doi: 10.1007/s12072-011-9262-2. Epub 2011 Mar 6.
10. Associations of metabolic factors, especially serum retinol-binding protein 4 (RBP4), with blood pressure in Japanese--the Tanno and Sobetsu study. Chiba M, etal., Endocr J. 2010;57(9):811-7. doi: 10.1507/endocrj.k10e-054. Epub 2010 Aug 24.
11. Elevated serum retinol-binding protein 4 concentrations are associated with chronic kidney disease but not with the higher carotid intima-media thickness in type 2 diabetic subjects. Chu CH, etal., Endocr J. 2011;58(10):841-7. doi: 10.1507/endocrj.ej11-0028. Epub 2011 Aug 4.
12. Retinol binding protein 4 as a candidate gene for type 2 diabetes and prediabetic intermediate traits. Craig RL, etal., Mol Genet Metab. 2007 Mar;90(3):338-44. Epub 2006 Dec 14.
13. Retinol-binding protein 4 levels and susceptibility to ischaemic events in men. Cubedo J, etal., Eur J Clin Invest. 2014;44(3):266-75. doi: 10.1111/eci.12229. Epub 2014 Jan 11.
14. [Serum levels of retinol-binding protein-4 and its association with metabolic syndrome in first-degree relatives of type 2 diabetes mellitus]. Gao S, etal., Zhonghua Yi Xue Za Zhi. 2009 Aug 11;89(30):2129-33.
15. Leptin, adiponectin, visfatin and retinol-binding protein-4 - mediators of comorbidities in patients with psoriasis? Gerdes S, etal., Exp Dermatol. 2012 Jan;21(1):43-7. doi: 10.1111/j.1600-0625.2011.01402.x.
16. Circulating retinol-binding protein 4, cardiovascular risk factors and prevalent cardiovascular disease in elderly. Ingelsson E, etal., Atherosclerosis. 2009 Sep;206(1):239-44. doi: 10.1016/j.atherosclerosis.2009.02.029. Epub 2009 Mar 11.
17. Elevated level of serum retinol-binding protein 4 in pregnancy-induced hypertension. Inoue S, etal., J Obstet Gynaecol Res. 2009 Apr;35(2):293-300. doi: 10.1111/j.1447-0756.2008.00950.x.
18. The relationship of novel adipokines, RBP4 and omentin-1, with carotid atherosclerosis severity and vulnerability. Kadoglou NP, etal., Atherosclerosis. 2014 Aug;235(2):606-12. doi: 10.1016/j.atherosclerosis.2014.05.957. Epub 2014 Jun 8.
19. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
20. Novel role for retinol-binding protein 4 in the regulation of blood pressure. Kraus BJ, etal., FASEB J. 2015 Aug;29(8):3133-40. doi: 10.1096/fj.14-266064. Epub 2015 Apr 24.
21. Association of retinol binding protein 4 and transthyretin with triglyceride levels and insulin resistance in rural thais with high type 2 diabetes risk. Kwanbunjan K, etal., BMC Endocr Disord. 2018 May 10;18(1):26. doi: 10.1186/s12902-018-0254-2.
22. Serum levels of retinol-binding protein-4 are associated with the presence and severity of coronary artery disease. Lambadiari V, etal., Cardiovasc Diabetol. 2014 Aug 21;13:121. doi: 10.1186/s12933-014-0121-z.
23. Association of serum retinol binding protein 4 and insulin resistance in apparently healthy adolescents. Lee DC, etal., Metabolism. 2007 Mar;56(3):327-31. doi: 10.1016/j.metabol.2006.10.011.
24. Retinol-binding protein 4 as a novel risk factor for cardiovascular disease in patients with coronary artery disease and hyperinsulinemia. Li F, etal., Am J Med Sci. 2014 Dec;348(6):474-9. doi: 10.1097/MAJ.0000000000000347.
25. Elevated RBP4 plasma levels were associated with diabetic retinopathy in type 2 diabetes. Li JY, etal., Biosci Rep. 2018 Sep 12;38(5):BSR20181100. doi: 10.1042/BSR20181100. Print 2018 Oct 31.
26. Retinol-binding protein 4 is closely correlated to blood pressure level and E/A in untreated essential hypertension patients. Li X, etal., Ann Palliat Med. 2019 Nov;8(5):645-650. doi: 10.21037/apm.2019.11.07.
27. Serum retinol-binding protein 4 levels in patients with diabetic retinopathy. Li ZZ, etal., J Int Med Res. 2010 Jan-Feb;38(1):95-9. doi: 10.1177/147323001003800111.
28. Retinol-Binding Protein 4 Predicts Lesion Volume (Determined by MRI) and Severity of Acute Ischemic Stroke. Liu C and Che Y, Neurotox Res. 2019 Jan;35(1):92-99. doi: 10.1007/s12640-018-9933-z. Epub 2018 Jul 20.
29. Circulating retinol binding protein 4 is associated with coronary lesion severity of patients with coronary artery disease. Liu Y, etal., Atherosclerosis. 2015 Jan;238(1):45-51. doi: 10.1016/j.atherosclerosis.2014.11.016. Epub 2014 Nov 20.
30. Retinol-Binding Protein-Dependent Cholesterol Uptake Regulates Macrophage Foam Cell Formation and Promotes Atherosclerosis. Liu Y, etal., Circulation. 2017 Apr 4;135(14):1339-1354. doi: 10.1161/CIRCULATIONAHA.116.024503. Epub 2017 Jan 25.
31. Serum markers of pre-eclampsia identified on proteomics. Lu Q, etal., J Obstet Gynaecol Res. 2016 Sep;42(9):1111-8. doi: 10.1111/jog.13037. Epub 2016 Jun 8.
32. Visceral obesity is associated with the metabolic syndrome and elevated plasma retinol binding protein-4 level in obstructive sleep apnea syndrome. Makino S, etal., Horm Metab Res. 2009 Mar;41(3):221-6. doi: 10.1055/s-0028-1100411. Epub 2008 Nov 10.
33. Retinol-binding protein 4 and prediction of incident coronary events in healthy men and women. Mallat Z, etal., J Clin Endocrinol Metab. 2009 Jan;94(1):255-60. doi: 10.1210/jc.2008-0253. Epub 2008 Oct 14.
34. Retinol-binding protein 4 and insulin resistance in preeclampsia. Masuyama H, etal., Endocr J. 2011;58(1):47-53. doi: 10.1507/endocrj.k10e-288. Epub 2010 Dec 14.
35. Retinol-binding protein 4 and nicotinamide phosphoribosyltransferase/visfatin in rat obesity models. Mercader J, etal., Horm Metab Res. 2008 Jul;40(7):467-72. Epub 2008 Mar 27.
36. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
37. MGDs mouse GO annotations MGD data from the GO Consortium
38. MGD IEA MGD IEA
39. Retinol-binding protein 4 : a possible role in cardiovascular complications. Mohapatra J, etal., Br J Pharmacol. 2011 Dec;164(8):1939-48. doi: 10.1111/j.1476-5381.2011.01492.x.
40. Physiological insights into all-trans-retinoic acid biosynthesis. Napoli JL Biochim Biophys Acta. 2012 Jan;1821(1):152-67. Epub 2011 May 19.
41. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
42. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
43. Elevated retinol binding protein 4 contributes to insulin resistance in spontaneously hypertensive rats. Ou HY, etal., Horm Metab Res. 2011 May;43(5):312-8. doi: 10.1055/s-0031-1271746. Epub 2011 Mar 1.
44. Microalbuminuria is a major determinant of elevated plasma retinol-binding protein 4 in type 2 diabetic patients. Raila J, etal., Kidney Int. 2007 Aug;72(4):505-11. doi: 10.1038/sj.ki.5002372. Epub 2007 Jun 13.
45. Mouse MP Annotation Import Pipeline RGD automated import pipeline
46. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
47. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
48. Coronary artery disease is associated with higher epicardial retinol-binding protein 4 (RBP4) and lower glucose transporter (GLUT) 4 levels in epicardial and subcutaneous adipose tissue. Salgado-Somoza A, etal., Clin Endocrinol (Oxf). 2012 Jan;76(1):51-8. doi: 10.1111/j.1365-2265.2011.04140.x.
49. Association between retinol binding protein 4 with atherosclerotic markers in obese children. Santanam N, etal., Minerva Endocrinol. 2016 Sep;41(3):291-7. Epub 2014 Oct 30.
50. Elevation of plasma retinol-binding protein 4 and reduction of plasma adiponectin in subjects with cerebral infarction. Sasaki M, etal., Metabolism. 2010 Apr;59(4):527-32. doi: 10.1016/j.metabol.2009.08.015. Epub 2009 Oct 20.
51. Phenotype in retinol deficiency due to a hereditary defect in retinol binding protein synthesis. Seeliger MW, etal., Invest Ophthalmol Vis Sci. 1999 Jan;40(1):3-11.
52. Retinol-binding protein-4 is decreased in patients with preeclampsia in comparison with normal pregnant women. Seol HJ, etal., J Perinat Med. 2011 May;39(3):287-9. doi: 10.1515/jpm.2011.016. Epub 2011 Feb 7.
53. Global gene expression profiling of chemically induced rat mammary gland carcinomas and adenomas. Shan L, etal., Toxicol Pathol. 2005;33(7):768-75.
54. Alterations in serum adipocyte fatty acid binding protein and retinol binding protein-4 in normal pregnancy and preeclampsia. Shangguan X, etal., Clin Chim Acta. 2009 Sep;407(1-2):58-61. doi: 10.1016/j.cca.2009.06.031. Epub 2009 Jun 29.
55. The inverse association between fasting blood glucose and the occurrence of gallbladder cancer in type 2 diabetes mellitus patients: a case-control study. Sheng BW, etal., J Cancer Res Clin Oncol. 2023 Jun 5. doi: 10.1007/s00432-023-04944-3.
56. The correlation of retinol-binding protein-4 and lipoprotein combine index with the prevalence and diagnosis of acute coronary syndrome. Si Y, etal., Heart Vessels. 2020 Nov;35(11):1494-1501. doi: 10.1007/s00380-020-01627-8. Epub 2020 May 24.
57. Retinol-binding protein-4 in women with untreated essential hypertension. Solini A, etal., Am J Hypertens. 2009 Sep;22(9):1001-6. doi: 10.1038/ajh.2009.116. Epub 2009 Jun 25.
58. Serum retinol-binding protein 4 is associated with the presence and severity of coronary artery disease in patients with subclinical hypothyroidism. Sun HX, etal., Aging (Albany NY). 2019 Jul 6;11(13):4510-4520. doi: 10.18632/aging.102065.
59. Elevated plasma retinol-binding protein 4 is associated with increased risk of type 2 diabetes in middle-aged and elderly Chinese adults. Sun L, etal., J Nutr. 2014 May;144(5):722-8. doi: 10.3945/jn.113.189860. Epub 2014 Mar 19.
60. Plasma retinol-binding protein 4 (RBP4) levels and risk of coronary heart disease: a prospective analysis among women in the nurses' health study. Sun Q, etal., Circulation. 2013 May 14;127(19):1938-47. doi: 10.1161/CIRCULATIONAHA.113.002073. Epub 2013 Apr 12.
61. Clinical significance of serum retinol binding protein-4 levels in patients with systemic sclerosis. Toyama T, etal., J Eur Acad Dermatol Venereol. 2013 Mar;27(3):337-44. doi: 10.1111/j.1468-3083.2011.04413.x. Epub 2011 Dec 26.
62. Maternal plasma retinol binding protein 4 in acute pyelonephritis during pregnancy. Vaisbuch E, etal., J Perinat Med. 2010 Jul;38(4):359-66. doi: 10.1515/jpm.2010.066.
63. Relationship of ANGPTL6 With Neonatal Glucose Homeostasis and Fat Mass Is Disrupted in Gestational Diabetic Pregnancies. Valencia-Martínez A, etal., J Clin Endocrinol Metab. 2022 Sep 28;107(10):e4078-e4085. doi: 10.1210/clinem/dgac414.
64. An RBP4 promoter polymorphism increases risk of type 2 diabetes. van Hoek M, etal., Diabetologia. 2008 Aug;51(8):1423-8. doi: 10.1007/s00125-008-1042-8. Epub 2008 May 22.
65. A genetic polymorphism in RBP4 is associated with coronary artery disease. Wan K, etal., Int J Mol Sci. 2014 Dec 3;15(12):22309-19. doi: 10.3390/ijms151222309.
66. Retinol-binding protein 4 regulates the biological functions and molecular mechanisms of JEG-3 cells. Wang F, etal.
67. Retinol binding protein 4 induces mitochondrial dysfunction and vascular oxidative damage. Wang J, etal., Atherosclerosis. 2015 Jun;240(2):335-44. doi: 10.1016/j.atherosclerosis.2015.03.036. Epub 2015 Mar 28.
68. Association among retinol-binding protein 4, small dense LDL cholesterol and oxidized LDL levels in dyslipidemia subjects. Wu J, etal., Clin Biochem. 2012 Jun;45(9):619-22. doi: 10.1016/j.clinbiochem.2012.02.022. Epub 2012 Mar 8.
69. Association of Retinol-Binding Protein 4 with Arteriovenous Fistula Dysfunction in Hemodialysis Patients. Wu Y, etal., Blood Purif. 2021;50(6):906-913. doi: 10.1159/000513418. Epub 2021 Feb 8.
70. Retinol-binding protein 4 is associated with impaired glucose regulation and microalbuminuria in a Chinese population. Xu M, etal., Diabetologia. 2009 Aug;52(8):1511-9. Epub 2009 Jun 9.
71. Insulin resistance in liver cirrhosis is not associated with circulating retinol-binding protein 4. Yagmur E, etal., Diabetes Care. 2007 May;30(5):1168-72. doi: 10.2337/dc06-2323. Epub 2007 Mar 2.
72. Elevated serum retinol-binding protein 4 levels are correlated with blood pressure in prehypertensive Chinese. Zhang JX, etal., J Hum Hypertens. 2017 Oct;31(10):611-615. doi: 10.1038/jhh.2017.44. Epub 2017 Jun 22.
73. Elevated retinol binding protein 4 levels are associated with atherosclerosis in diabetic rats via JAK2/STAT3 signaling pathway. Zhou W, etal., World J Diabetes. 2021 Apr 15;12(4):466-479. doi: 10.4239/wjd.v12.i4.466.
74. Evaluation of serum retinol-binding protein-4 levels as a biomarker of poor short-term prognosis in ischemic stroke. Zhu YY, etal., Biosci Rep. 2018 Sep 12;38(5):BSR20180786. doi: 10.1042/BSR20180786. Print 2018 Oct 31.
Additional References at PubMed
PMID:1613076   PMID:2004789   PMID:2060705   PMID:7558004   PMID:7613027   PMID:8043950   PMID:8499657   PMID:8589516   PMID:8661737   PMID:9022057   PMID:9193722   PMID:9721191  
PMID:10349636   PMID:10469643   PMID:10944490   PMID:11042159   PMID:11076861   PMID:11130978   PMID:11562477   PMID:11919667   PMID:12048218   PMID:12477932   PMID:12484775   PMID:12663486  
PMID:12819125   PMID:14610273   PMID:15314099   PMID:15489334   PMID:15767668   PMID:15994349   PMID:16034410   PMID:16141072   PMID:16141073   PMID:16289749   PMID:16586441   PMID:16602821  
PMID:17032746   PMID:17270348   PMID:18093970   PMID:18195010   PMID:18285525   PMID:18554416   PMID:18769064   PMID:19047629   PMID:19147488   PMID:19389484   PMID:19454764   PMID:19460132  
PMID:19664187   PMID:20040693   PMID:20110328   PMID:20627934   PMID:21084379   PMID:21267068   PMID:21285397   PMID:21873635   PMID:21983273   PMID:22045663   PMID:22253419   PMID:22341881  
PMID:22431523   PMID:22739378   PMID:22826435   PMID:23105095   PMID:23193184   PMID:23224267   PMID:23839944   PMID:23840311   PMID:23871845   PMID:23959802   PMID:24186946   PMID:24194600  
PMID:24401276   PMID:24590924   PMID:24606904   PMID:24852372   PMID:24956283   PMID:25524914   PMID:25728271   PMID:25732851   PMID:26564180   PMID:26631740   PMID:26901059   PMID:26936962  
PMID:26974396   PMID:27100622   PMID:27626380   PMID:27740873   PMID:27797907   PMID:28400700   PMID:28813718   PMID:28849085   PMID:28964716   PMID:29330472   PMID:29567832   PMID:29892071  
PMID:30126844   PMID:30782214   PMID:30916783   PMID:31112136   PMID:32001436   PMID:32290105   PMID:32325033   PMID:33065162   PMID:33135589   PMID:33199363   PMID:33214151   PMID:34742949  
PMID:35830795   PMID:36030930   PMID:36354743   PMID:36410431   PMID:36572267   PMID:36920550   PMID:37192624   PMID:38355793   PMID:38521877   PMID:39031684   PMID:39305123  


Genomics

Comparative Map Data
Rbp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391938,105,068 - 38,113,769 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1938,105,077 - 38,113,729 (-)EnsemblGRCm39 Ensembl
GRCm381938,116,620 - 38,125,321 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1938,116,629 - 38,125,281 (-)EnsemblGRCm38mm10GRCm38
MGSCv371938,191,110 - 38,199,811 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361938,181,773 - 38,190,392 (-)NCBIMGSCv36mm8
Celera1938,908,311 - 38,919,212 (-)NCBICelera
Cytogenetic Map19C2NCBI
cM Map1932.75NCBI
RBP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381093,591,694 - 93,601,744 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1093,591,687 - 93,601,744 (-)EnsemblGRCh38hg38GRCh38
GRCh371095,351,451 - 95,361,501 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361095,341,583 - 95,350,983 (-)NCBINCBI36Build 36hg18NCBI36
Build 341095,341,583 - 95,350,983NCBI
Celera1089,092,718 - 89,102,118 (-)NCBICelera
Cytogenetic Map10q23.33NCBI
HuRef1088,979,353 - 88,988,753 (-)NCBIHuRef
CHM1_11095,634,147 - 95,643,547 (-)NCBICHM1_1
T2T-CHM13v2.01094,471,646 - 94,481,695 (-)NCBIT2T-CHM13v2.0
Rbp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81245,306,349 - 245,313,551 (-)NCBIGRCr8
mRatBN7.21235,893,917 - 235,901,315 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1235,893,917 - 235,901,399 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1244,315,318 - 244,322,517 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01251,211,097 - 251,218,299 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01244,049,331 - 244,056,533 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01256,806,476 - 256,813,678 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1256,806,472 - 256,813,711 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01264,286,998 - 264,294,396 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41242,443,795 - 242,450,997 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11242,637,193 - 242,644,147 (-)NCBI
Celera1232,987,269 - 232,994,470 (-)NCBICelera
RH 3.4 Map11581.5RGD
Cytogenetic Map1q53NCBI
Rbp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955507108,669 - 120,584 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955507112,342 - 120,050 (-)NCBIChiLan1.0ChiLan1.0
RBP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28105,629,725 - 105,639,359 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110105,635,040 - 105,644,675 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01090,337,879 - 90,347,530 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11093,848,166 - 93,857,679 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1093,848,166 - 93,857,887 (-)Ensemblpanpan1.1panPan2
RBP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1287,822,936 - 7,830,735 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl287,822,944 - 7,830,750 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha287,999,367 - 8,007,133 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0288,083,216 - 8,090,965 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl288,083,226 - 8,090,980 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1287,802,939 - 7,810,708 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0287,832,158 - 7,839,906 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0288,002,083 - 8,009,832 (-)NCBIUU_Cfam_GSD_1.0
Rbp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721339,768,612 - 39,777,592 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366011,402,691 - 1,410,208 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366011,401,215 - 1,410,195 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RBP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14105,037,464 - 105,044,765 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114105,037,360 - 105,044,552 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214114,769,053 - 114,775,781 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RBP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1986,831,042 - 86,840,668 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl986,830,957 - 86,840,250 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604847,606,135 - 47,615,805 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rbp4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247374,791,628 - 4,800,989 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247374,795,054 - 4,800,830 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rbp4
385 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:185
Count of miRNA genes:91
Interacting mature miRNAs:97
Transcripts:ENSMUST00000025951, ENSMUST00000112335
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13506250Renmq1_mrenal mercury accumulation QTL 1 (mouse)192738559461385705Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192023431454234461Mouse
1302170Tanidd1_mtally ho associated non-insulin dependednt diabetes mellitus 1 (mouse)Not determined193675259761420004Mouse
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19531332639313470Mouse
1301336Alcp23_malcohol preference locus 23 (mouse)Not determined191591260749912719Mouse
1558876W3q14_mweight 3 weeks QTL 14 (mouse)Not determined192231332653911504Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19978745343787602Mouse
1301633Alcp24_malcohol preference locus 24 (mouse)Not determined191591260749912719Mouse
14928311Manh85_mmandible shape 85 (mouse)191191478945914789Mouse
1301639Stnn_mstriatal neuron number (mouse)Not determined193395195261420004Mouse
1301451Ath16_matherosclerosis 16 (mouse)Not determined192542691759427005Mouse
1300683Fembm7_mfemoral bone morphometry 7 (mouse)Not determined193014122461420004Mouse
4141659Pbwg20_mpostnatal body weight growth 20 (mouse)Not determined192137870555378928Mouse
4141019Tgq29_mtriglyceride QTL 29 (mouse)Not determined3459678661420004Mouse
1301942Pas13_mpulmonary adenoma susceptibility 13 (mouse)Not determined193014123161420004Mouse
10413881Moe2_mmodifier of epilepsy 2 (mouse)191492301648923138Mouse
1302004Lfp2_mlong free running period 2 (mouse)Not determined191829516252295381Mouse
12790634Ebm1_mEpidermolysis Bullosa modifier 1 (mouse)192498843958988439Mouse
1300856Nobq2_mNew Zealand obese QTL 2 (mouse)Not determined193089788061420004Mouse
4141138Femwf11_mfemur work to failure 11 (mouse)Not determined2814034861420004Mouse
4141650Chldq9_mcholesterol and HDL QTL 9 (mouse)Not determined193788298261420004Mouse
13504736Ifvrq6_minfluenza virus resistance QTL 6 (mouse)193690291044913949Mouse
1301410Cd8mts6_mCD8 memory T cell subset 6 (mouse)Not determined193014123161420004Mouse
1301479Sluc1_msusceptibility to lung cancer 1 (mouse)Not determined193601694446761521Mouse
4142343Moen2_mmodifier of engrailed QTL 2 (mouse)Not determined192023431454234461Mouse
1302123Tlsr8_mthymic lymphoma suppressor region 8 (mouse)Not determined192513600242388916Mouse
1302063Eae19_mexperimental allergic encephalomyelitis 19 (mouse)Not determined191829516252295381Mouse
1301741Lith2_mlithogenic gene 2 (mouse)Not determined193299215861420004Mouse
1301228Iba4_minduction of brown adipocytes 4 (mouse)Not determined19930571543305821Mouse

Markers in Region
RH94744  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Celera1938,908,356 - 38,908,488UniSTS
Cytogenetic Map19D1UniSTS
cM Map1938.0UniSTS
Rbp4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381938,116,815 - 38,118,298UniSTSGRCm38
MGSCv371938,191,305 - 38,192,788UniSTSGRCm37
Celera1938,908,506 - 38,909,989UniSTS
Cytogenetic Map19D1UniSTS
cM Map1938.0UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000025951   ⟹   ENSMUSP00000025951
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1938,105,077 - 38,113,696 (-)Ensembl
GRCm38.p6 Ensembl1938,116,629 - 38,125,248 (-)Ensembl
Ensembl Acc Id: ENSMUST00000112335   ⟹   ENSMUSP00000107954
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1938,105,078 - 38,113,276 (-)Ensembl
GRCm38.p6 Ensembl1938,116,630 - 38,124,828 (-)Ensembl
Ensembl Acc Id: ENSMUST00000236283   ⟹   ENSMUSP00000157743
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1938,112,518 - 38,113,173 (-)Ensembl
GRCm38.p6 Ensembl1938,124,070 - 38,124,725 (-)Ensembl
Ensembl Acc Id: ENSMUST00000237287   ⟹   ENSMUSP00000157796
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1938,112,744 - 38,113,729 (-)Ensembl
GRCm38.p6 Ensembl1938,124,296 - 38,125,281 (-)Ensembl
RefSeq Acc Id: NM_001159487   ⟹   NP_001152959
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391938,105,068 - 38,113,769 (-)NCBI
GRCm381938,116,620 - 38,125,321 (-)ENTREZGENE
MGSCv371938,191,110 - 38,199,811 (-)RGD
Celera1938,908,311 - 38,919,212 (-)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_011255   ⟹   NP_035385
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391938,105,068 - 38,113,259 (-)NCBI
GRCm381938,116,620 - 38,124,811 (-)NCBI
MGSCv371938,191,110 - 38,199,811 (-)RGD
Celera1938,908,311 - 38,919,212 (-)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_035385   ⟸   NM_011255
- Peptide Label: isoform 2 precursor
- UniProtKB: P70357 (UniProtKB/Swiss-Prot),   Q566I5 (UniProtKB/Swiss-Prot),   Q00724 (UniProtKB/Swiss-Prot),   Q3TF08 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001152959   ⟸   NM_001159487
- Peptide Label: isoform 1
- UniProtKB: H7BWY6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000157796   ⟸   ENSMUST00000237287
Ensembl Acc Id: ENSMUSP00000025951   ⟸   ENSMUST00000025951
Ensembl Acc Id: ENSMUSP00000157743   ⟸   ENSMUST00000236283
Ensembl Acc Id: ENSMUSP00000107954   ⟸   ENSMUST00000112335
Protein Domains
Lipocalin/cytosolic fatty-acid binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q00724-F1-model_v2 AlphaFold Q00724 1-201 view protein structure

Promoters
RGD ID:13679402
Promoter ID:EPDNEW_M23850
Type:multiple initiation site
Name:Rbp4_1
Description:Mus musculus retinol binding protein 4, plasma , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381938,124,808 - 38,124,868EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97879 AgrOrtholog
Ensembl Genes ENSMUSG00000024990 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000025951 ENTREZGENE
  ENSMUST00000025951.14 UniProtKB/TrEMBL
  ENSMUST00000112335 ENTREZGENE
  ENSMUST00000112335.4 UniProtKB/Swiss-Prot
  ENSMUST00000236283.2 UniProtKB/TrEMBL
  ENSMUST00000237287.2 UniProtKB/TrEMBL
Gene3D-CATH 2.40.128.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Calycin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipocalin_ApoD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipocalin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipocln_cytosolic_FA-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Retinol-bd/Purpurin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:19662 UniProtKB/Swiss-Prot
MGD MGI:97879 ENTREZGENE
NCBI Gene 19662 ENTREZGENE
PANTHER PTHR11873 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RETINOL-BINDING PROTEIN 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lipocalin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB RBP4 RGD
PhenoGen Rbp4 PhenoGen
PIRSF Lipocalin_ApoD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RBP_purpurin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS LIPOCALIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RETINOLBNDNG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LIPOCALIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50814 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A494B9P3_MOUSE UniProtKB/TrEMBL
  A0A494B9T2_MOUSE UniProtKB/TrEMBL
  H7BWY6 ENTREZGENE, UniProtKB/TrEMBL
  P70357 ENTREZGENE
  Q00724 ENTREZGENE
  Q3TF08 ENTREZGENE, UniProtKB/TrEMBL
  Q566I5 ENTREZGENE
  RET4_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary P70357 UniProtKB/Swiss-Prot
  Q566I5 UniProtKB/Swiss-Prot