Orc4 (origin recognition complex, subunit 4) - Rat Genome Database

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Gene: Orc4 (origin recognition complex, subunit 4) Rattus norvegicus
Analyze
Symbol: Orc4
Name: origin recognition complex, subunit 4
RGD ID: 735212
Description: Predicted to enable DNA replication origin binding activity and nucleotide binding activity. Predicted to be involved in DNA replication initiation; polar body extrusion after meiotic divisions; and protein polymerization. Predicted to act upstream of or within DNA replication. Predicted to be located in chromosome, telomeric region; cytosol; and nuclear lumen. Predicted to be part of nuclear origin of replication recognition complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 2. Orthologous to human ORC4 (origin recognition complex subunit 4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC72574; Orc4l; Orc4l2; origin recognition complex subunit 4; origin recognition complex, subunit 4-like; origin recognition complex, subunit 4-like (S. cerevisiae); origin recognition complex, subunit 4-like (yeast); origin recognition complex, subunit 4-like 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8353,700,046 - 53,743,293 (-)NCBIGRCr8
mRatBN7.2333,290,844 - 33,334,022 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl333,294,355 - 33,333,824 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx336,677,728 - 36,716,383 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0345,262,461 - 45,301,116 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0343,084,856 - 43,123,482 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0333,034,913 - 33,075,833 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl333,037,034 - 33,075,685 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0338,201,914 - 38,240,600 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4329,813,264 - 29,851,852 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera331,495,196 - 31,533,857 (-)NCBICelera
Cytogenetic Map3q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Identification and characterization of MmORC4 and MmORC5, two subunits of the mouse origin of replication recognition complex. Springer J, etal., Chromosoma 1999 Aug;108(4):243-9.
8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:8915587   PMID:9353276   PMID:17716973   PMID:19135898   PMID:20932478   PMID:21383955   PMID:24270157  


Genomics

Comparative Map Data
Orc4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8353,700,046 - 53,743,293 (-)NCBIGRCr8
mRatBN7.2333,290,844 - 33,334,022 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl333,294,355 - 33,333,824 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx336,677,728 - 36,716,383 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0345,262,461 - 45,301,116 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0343,084,856 - 43,123,482 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0333,034,913 - 33,075,833 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl333,037,034 - 33,075,685 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0338,201,914 - 38,240,600 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4329,813,264 - 29,851,852 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera331,495,196 - 31,533,857 (-)NCBICelera
Cytogenetic Map3q12NCBI
ORC4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382147,930,396 - 148,021,551 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2147,930,396 - 148,021,604 (-)EnsemblGRCh38hg38GRCh38
GRCh372148,687,965 - 148,779,120 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362148,408,202 - 148,495,606 (-)NCBINCBI36Build 36hg18NCBI36
Build 342148,525,463 - 148,612,868NCBI
Celera2142,405,877 - 142,493,295 (-)NCBICelera
Cytogenetic Map2q23.1NCBI
HuRef2140,685,335 - 140,777,468 (-)NCBIHuRef
CHM1_12148,693,611 - 148,784,819 (-)NCBICHM1_1
T2T-CHM13v2.02148,380,848 - 148,472,005 (-)NCBIT2T-CHM13v2.0
Orc4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39248,792,836 - 48,840,287 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl248,792,836 - 48,840,289 (-)EnsemblGRCm39 Ensembl
GRCm38248,902,824 - 48,952,902 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl248,902,824 - 48,950,277 (-)EnsemblGRCm38mm10GRCm38
MGSCv37248,758,274 - 48,804,787 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36248,724,861 - 48,771,243 (-)NCBIMGSCv36mm8
Celera250,575,226 - 50,621,420 (-)NCBICelera
Cytogenetic Map2C1.1NCBI
cM Map228.42NCBI
Orc4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544013,932,495 - 14,006,806 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544013,933,896 - 14,006,808 (-)NCBIChiLan1.0ChiLan1.0
ORC4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21326,909,798 - 26,997,388 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B26,924,800 - 27,012,354 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B11,841,808 - 11,931,620 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B152,291,976 - 152,379,639 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B152,292,822 - 152,379,487 (-)Ensemblpanpan1.1panPan2
ORC4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11949,728,812 - 49,815,599 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1949,728,344 - 49,815,604 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1949,852,526 - 49,939,229 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01951,201,322 - 51,288,103 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1951,193,458 - 51,288,099 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11949,847,294 - 49,933,994 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01949,981,280 - 50,068,020 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01951,378,650 - 51,465,414 (-)NCBIUU_Cfam_GSD_1.0
Orc4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303112,424,304 - 112,486,767 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646929,131,789 - 29,194,863 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646929,131,892 - 29,193,258 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ORC4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl154,096,647 - 4,171,398 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1154,096,539 - 4,176,332 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2153,748,071 - 3,824,433 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ORC4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11033,314,020 - 33,401,770 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1033,314,271 - 33,355,588 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040166,136,574 - 166,225,926 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Orc4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624866622,859 - 716,787 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624866626,556 - 716,725 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Orc4
208 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:20
Count of miRNA genes:18
Interacting mature miRNAs:19
Transcripts:ENSRNOT00000006937
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)31077870450302886Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)heart rate (CMO:0000002)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)heart rate (CMO:0000002)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)body weight (CMO:0000012)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)body weight (CMO:0000012)31737470335528639Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145447233430Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)31831145447233430Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)31831145447233430Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)31831145447233430Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)31831145447233430Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)31831145447233430Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)31831145447233430Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
1298073Cm13Cardiac mass QTL 132.5heart mass (VT:0007028)heart wet weight (CMO:0000069)32501391138192233Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)32749462144188411Rat
2313049Bss72Bone structure and strength QTL 722.60.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)32749462150302886Rat
2313076Bss74Bone structure and strength QTL 7420.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)32749462150302886Rat
2313079Bss73Bone structure and strength QTL 731.5tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)32749462150302886Rat
2313093Bmd77Bone mineral density QTL 772.20.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)32749462150302886Rat
2313101Bmd76Bone mineral density QTL 763.60.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)32749462150302886Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32793691972936919Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32824968773249687Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32824968773249687Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32824968773249687Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32824968773249687Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32846857173468571Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32846857173468571Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33068464275684642Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33068464275684642Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
11565451Bw177Body weight QTL 1770.002body mass (VT:0001259)body weight (CMO:0000012)33142640370668733Rat
11565452Kidm57Kidney mass QTL 570.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33142640370668733Rat
12879866Cm94Cardiac mass QTL 940.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33142640370668733Rat
12879867Cm95Cardiac mass QTL 950.047heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33142640370668733Rat
12879868Am6Aortic mass QTL 60.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33142640370668733Rat
2301400Cm68Cardiac mass QTL 680.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33142640370668733Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 36 48 32 19 32 8 8 74 34 41 11 8
Low 7 9 9 9 3 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001429833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_199092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC060516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X94507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000006937   ⟹   ENSRNOP00000006937
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl333,294,392 - 33,333,055 (-)Ensembl
Rnor_6.0 Ensembl333,037,034 - 33,075,685 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000099552   ⟹   ENSRNOP00000085949
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl333,294,367 - 33,333,045 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103065   ⟹   ENSRNOP00000077265
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl333,294,365 - 33,333,824 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109006   ⟹   ENSRNOP00000083931
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl333,294,583 - 33,333,055 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109819   ⟹   ENSRNOP00000077188
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl333,294,355 - 33,319,460 (-)Ensembl
RefSeq Acc Id: NM_199092   ⟹   NP_954523
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,703,611 - 53,742,264 (-)NCBI
mRatBN7.2333,294,351 - 33,333,005 (-)NCBI
Rnor_6.0333,037,032 - 33,075,685 (-)NCBI
Rnor_5.0338,201,914 - 38,240,600 (-)NCBI
RGSC_v3.4329,813,264 - 29,851,852 (-)RGD
Celera331,495,196 - 31,533,857 (-)RGD
Sequence:
RefSeq Acc Id: XM_008761705   ⟹   XP_008759927
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,700,046 - 53,742,311 (-)NCBI
mRatBN7.2333,292,232 - 33,333,041 (-)NCBI
Rnor_6.0333,035,204 - 33,075,832 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039104460   ⟹   XP_038960388
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,700,046 - 53,742,311 (-)NCBI
mRatBN7.2333,290,844 - 33,333,041 (-)NCBI
RefSeq Acc Id: XM_039104461   ⟹   XP_038960389
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,700,046 - 53,742,320 (-)NCBI
mRatBN7.2333,290,844 - 33,333,041 (-)NCBI
RefSeq Acc Id: XM_039104463   ⟹   XP_038960391
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,700,046 - 53,742,322 (-)NCBI
mRatBN7.2333,290,844 - 33,333,041 (-)NCBI
RefSeq Acc Id: XM_039104464   ⟹   XP_038960392
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,700,046 - 53,743,117 (-)NCBI
mRatBN7.2333,290,844 - 33,333,858 (-)NCBI
RefSeq Acc Id: XM_039104465   ⟹   XP_038960393
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,700,046 - 53,743,117 (-)NCBI
mRatBN7.2333,290,844 - 33,333,858 (-)NCBI
RefSeq Acc Id: XM_039104466   ⟹   XP_038960394
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,700,046 - 53,735,172 (-)NCBI
mRatBN7.2333,290,844 - 33,325,923 (-)NCBI
RefSeq Acc Id: XM_039104469   ⟹   XP_038960397
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,700,046 - 53,743,117 (-)NCBI
mRatBN7.2333,290,844 - 33,333,858 (-)NCBI
RefSeq Acc Id: XM_039104470   ⟹   XP_038960398
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,700,046 - 53,743,293 (-)NCBI
mRatBN7.2333,290,844 - 33,334,022 (-)NCBI
RefSeq Acc Id: XM_039104471   ⟹   XP_038960399
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,700,046 - 53,743,103 (-)NCBI
mRatBN7.2333,290,844 - 33,333,847 (-)NCBI
RefSeq Acc Id: XM_039104472   ⟹   XP_038960400
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,700,046 - 53,742,128 (-)NCBI
mRatBN7.2333,290,844 - 33,332,897 (-)NCBI
RefSeq Acc Id: XM_039104473   ⟹   XP_038960401
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,700,046 - 53,735,203 (-)NCBI
mRatBN7.2333,290,844 - 33,325,944 (-)NCBI
RefSeq Acc Id: XM_039104474   ⟹   XP_038960402
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,700,046 - 53,743,117 (-)NCBI
mRatBN7.2333,290,844 - 33,333,858 (-)NCBI
RefSeq Acc Id: XM_063283239   ⟹   XP_063139309
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,700,046 - 53,743,278 (-)NCBI
RefSeq Acc Id: XM_063283240   ⟹   XP_063139310
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,700,046 - 53,743,101 (-)NCBI
RefSeq Acc Id: XM_063283242   ⟹   XP_063139312
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,700,046 - 53,742,311 (-)NCBI
RefSeq Acc Id: XM_063283243   ⟹   XP_063139313
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,700,046 - 53,742,322 (-)NCBI
RefSeq Acc Id: XM_063283244   ⟹   XP_063139314
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,700,046 - 53,743,101 (-)NCBI
RefSeq Acc Id: XM_063283246   ⟹   XP_063139316
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8353,700,046 - 53,743,103 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001416762 (Get FASTA)   NCBI Sequence Viewer  
  NP_954523 (Get FASTA)   NCBI Sequence Viewer  
  XP_008759927 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960388 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960389 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960391 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960392 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960393 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960394 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960397 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960398 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960399 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960400 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960401 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960402 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139309 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139310 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139312 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139313 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139314 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139316 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH60516 (Get FASTA)   NCBI Sequence Viewer  
  EDM00467 (Get FASTA)   NCBI Sequence Viewer  
  EDM00468 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006937
  ENSRNOP00000006937.4
  ENSRNOP00000077188.1
  ENSRNOP00000077265
  ENSRNOP00000077265.1
  ENSRNOP00000083931.1
  ENSRNOP00000085949.1
  ENSRNOP00055001892
  ENSRNOP00060046208
  ENSRNOP00065009734
GenBank Protein Q6P9Z8 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_954523   ⟸   NM_199092
- UniProtKB: Q6P9Z8 (UniProtKB/Swiss-Prot),   A6JEZ2 (UniProtKB/TrEMBL),   A0A8L2Q2Z8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759927   ⟸   XM_008761705
- Peptide Label: isoform X4
- UniProtKB: A0A8I5Y5K9 (UniProtKB/TrEMBL),   A0A8L2Q2Z8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000006937   ⟸   ENSRNOT00000006937
RefSeq Acc Id: XP_038960398   ⟸   XM_039104470
- Peptide Label: isoform X3
- UniProtKB: A0A8L2Q2Z8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960397   ⟸   XM_039104469
- Peptide Label: isoform X3
- UniProtKB: A0A8L2Q2Z8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960402   ⟸   XM_039104474
- Peptide Label: isoform X6
- UniProtKB: A0A8L2Q2Z8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960393   ⟸   XM_039104465
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q2Z8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960392   ⟸   XM_039104464
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q2Z8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960399   ⟸   XM_039104471
- Peptide Label: isoform X3
- UniProtKB: A0A8L2Q2Z8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960391   ⟸   XM_039104463
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q2Z8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960389   ⟸   XM_039104461
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q2Z8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960388   ⟸   XM_039104460
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q2Z8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960400   ⟸   XM_039104472
- Peptide Label: isoform X3
- UniProtKB: A0A8L2Q2Z8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960401   ⟸   XM_039104473
- Peptide Label: isoform X6
- UniProtKB: A0A8L2Q2Z8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960394   ⟸   XM_039104466
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A4W8 (UniProtKB/TrEMBL),   A0A8L2Q2Z8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000083931   ⟸   ENSRNOT00000109006
RefSeq Acc Id: ENSRNOP00000077188   ⟸   ENSRNOT00000109819
RefSeq Acc Id: ENSRNOP00000077265   ⟸   ENSRNOT00000103065
RefSeq Acc Id: ENSRNOP00000085949   ⟸   ENSRNOT00000099552
RefSeq Acc Id: XP_063139309   ⟸   XM_063283239
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q2Z8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139316   ⟸   XM_063283246
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063139314   ⟸   XM_063283244
- Peptide Label: isoform X4
- UniProtKB: A0A8L2Q2Z8 (UniProtKB/TrEMBL),   A0A8I5Y5K9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139310   ⟸   XM_063283240
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q2Z8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139313   ⟸   XM_063283243
- Peptide Label: isoform X4
- UniProtKB: A0A8L2Q2Z8 (UniProtKB/TrEMBL),   A0A8I5Y5K9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139312   ⟸   XM_063283242
- Peptide Label: isoform X4
- UniProtKB: A0A8L2Q2Z8 (UniProtKB/TrEMBL),   A0A8I5Y5K9 (UniProtKB/TrEMBL)
Protein Domains
AAA+ ATPase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6P9Z8-F1-model_v2 AlphaFold Q6P9Z8 1-434 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692068
Promoter ID:EPDNEW_R2593
Type:multiple initiation site
Name:Orc4_1
Description:origin recognition complex, subunit 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0333,075,692 - 33,075,752EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735212 AgrOrtholog
BioCyc Gene G2FUF-49787 BioCyc
Ensembl Genes ENSRNOG00000005021 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055001565 UniProtKB/Swiss-Prot
  ENSRNOG00060032221 UniProtKB/Swiss-Prot
  ENSRNOG00065008296 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006937 ENTREZGENE
  ENSRNOT00000006937.6 UniProtKB/TrEMBL
  ENSRNOT00000099552.1 UniProtKB/TrEMBL
  ENSRNOT00000103065.1 UniProtKB/TrEMBL
  ENSRNOT00000109006.1 UniProtKB/TrEMBL
  ENSRNOT00000109819.1 UniProtKB/TrEMBL
  ENSRNOT00055002515 UniProtKB/Swiss-Prot
  ENSRNOT00060055865 UniProtKB/Swiss-Prot
  ENSRNOT00065013163 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5598062 IMAGE-MGC_LOAD
InterPro AAA+_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AAA_16 UniProtKB/TrEMBL
  ATPase_AAA_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_dom UniProtKB/TrEMBL
  ORC4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ORC4_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:295596 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72574 IMAGE-MGC_LOAD
NCBI Gene 295596 ENTREZGENE
PANTHER ORIGIN RECOGNITION COMPLEX SUBUNIT 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12087 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AAA_16 UniProtKB/TrEMBL
  ATPase_2 UniProtKB/TrEMBL
  ORC4_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Orc4 PhenoGen
PIRSF ORC4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005021 RatGTEx
  ENSRNOG00055001565 RatGTEx
  ENSRNOG00060032221 RatGTEx
  ENSRNOG00065008296 RatGTEx
SMART AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5Y5K9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y9D5_RAT UniProtKB/TrEMBL
  A0A8I5ZY14_RAT UniProtKB/TrEMBL
  A0A8I6A4W8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q2Z8 ENTREZGENE, UniProtKB/TrEMBL
  A6JEZ2 ENTREZGENE, UniProtKB/TrEMBL
  ORC4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-02 Orc4  origin recognition complex, subunit 4  Orc4l2  origin recognition complex, subunit 4-like 2  Data merged from RGD:619987 737654 APPROVED
2011-08-02 Orc4  origin recognition complex, subunit 4  Orc4l  origin recognition complex, subunit 4-like (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Orc4l  origin recognition complex, subunit 4-like (yeast)  Orc4l  origin recognition complex, subunit 4-like (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Orc4l  origin recognition complex, subunit 4-like (S. cerevisiae)    origin recognition complex, subunit 4-like (yeast)  Name updated 1299863 APPROVED
2002-08-07 Orc4  origin recognition complex, subunit 4      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the postsynaptic density 633356