Tbx3 (T-box transcription factor 3) - Rat Genome Database

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Gene: Tbx3 (T-box transcription factor 3) Rattus norvegicus
Analyze
Symbol: Tbx3
Name: T-box transcription factor 3
RGD ID: 735203
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in negative regulation of apoptotic process. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be part of transcription regulator complex. Predicted to be active in chromatin; cilium; and nucleus. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in ulnar-mammary syndrome. Orthologous to human TBX3 (T-box transcription factor 3); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: T-box 3; T-box 3 (ulnar mammary syndrome); T-box protein 3; T-box transcription factor TBX3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81242,540,378 - 42,555,490 (-)NCBIGRCr8
mRatBN7.21236,879,924 - 36,894,849 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1236,881,445 - 36,893,708 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1238,058,977 - 38,070,162 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01238,672,813 - 38,684,003 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01237,725,254 - 37,736,439 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01242,479,518 - 42,494,588 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1242,480,560 - 42,492,526 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01244,326,928 - 44,342,670 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41238,155,494 - 38,166,670 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11238,018,881 - 38,030,058 (-)NCBI
Celera1238,555,497 - 38,566,664 (-)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,8-cineole  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
actinomycin D  (ISO)
afimoxifene  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (ISO)
amitrole  (EXP,ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
butanal  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cannabidiol  (EXP)
carbon nanotube  (ISO)
carmustine  (ISO)
carnosic acid  (ISO)
cefaloridine  (EXP)
chlordecone  (ISO)
ciguatoxin CTX1B  (ISO)
clofibrate  (ISO)
cobalt atom  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
Cuprizon  (EXP)
cycloheximide  (ISO)
cylindrospermopsin  (ISO)
cyproconazole  (ISO)
dexamethasone  (EXP,ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dimethoate  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
endosulfan  (EXP)
enzacamene  (ISO)
epoxiconazole  (ISO)
fenvalerate  (ISO)
folic acid  (ISO)
fonofos  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
GW 4064  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
Iopanoic acid  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
metformin  (EXP)
methimazole  (EXP,ISO)
methoxychlor  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Muraglitazar  (EXP)
N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide  (ISO)
nickel atom  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
PD 0325901  (ISO)
PD173074  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
PF-3758309  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propanal  (ISO)
propiconazole  (ISO)
Ptaquiloside  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
ritodrine  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sorafenib  (ISO)
sulfadimethoxine  (EXP)
sulindac  (ISO)
sunitinib  (ISO)
taiwanin C  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (IEA,ISO)
anterior/posterior axis specification, embryo  (IEA,ISO,ISS)
atrioventricular bundle cell differentiation  (IEA,ISO)
atrioventricular canal development  (IEA,ISO)
atrioventricular canal morphogenesis  (IEA,ISO)
blood vessel development  (IEA,ISO)
branching involved in mammary gland duct morphogenesis  (IEA,ISO)
cardiac epithelial to mesenchymal transition  (IEA,ISO)
cardiac jelly development  (IEA,ISO)
cardiac muscle cell differentiation  (IEA,ISO)
cardiac muscle cell fate commitment  (IEA,ISO)
cell fate specification  (IBA)
cellular senescence  (IEA,ISO,ISS)
DNA-templated transcription  (IEA,ISO)
embryonic digit morphogenesis  (IEA,ISO,ISS)
embryonic forelimb morphogenesis  (IEA,ISO,ISS)
embryonic heart tube development  (IEA,ISO)
embryonic hindlimb morphogenesis  (IEA,ISO)
endocardial cushion formation  (IEA,ISO)
female genitalia development  (IEA,ISO,ISS)
follicle-stimulating hormone secretion  (IEA,ISO,ISS)
forelimb morphogenesis  (IEA,ISO)
heart looping  (IEA,ISO)
heart morphogenesis  (IEA,ISO)
hepatoblast differentiation  (IEA,ISO)
in utero embryonic development  (IEA,ISO)
inner ear morphogenesis  (IEA,ISO)
limb morphogenesis  (IEA,ISO)
limbic system development  (IEA,ISO)
luteinizing hormone secretion  (IEA,ISO,ISS)
male genitalia development  (IEA,ISO,ISS)
mammary gland development  (IEA,ISO,ISS)
mammary placode formation  (IEA,ISO)
mesoderm morphogenesis  (IEA,ISO,ISS)
negative regulation of apoptotic process  (IEA,IMP,ISO,ISS)
negative regulation of cell proliferation involved in heart morphogenesis  (IEA,ISO)
negative regulation of DNA-templated transcription  (IEA,ISO,ISS)
negative regulation of epithelial cell differentiation  (IEA,ISO)
negative regulation of myoblast differentiation  (IEA,ISO,ISS)
negative regulation of stem cell differentiation  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,IMP,ISO)
outflow tract morphogenesis  (IEA,ISO)
positive regulation of cell cycle  (IEA,ISO,ISS)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of stem cell proliferation  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
regulation of cell population proliferation  (IEA,ISO)
regulation of DNA-templated transcription  (IEA)
regulation of protein complex stability  (IEA,ISO)
regulation of protein stability  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IBA)
roof of mouth development  (IEA,ISO)
semicircular canal morphogenesis  (IEA,ISO)
sinoatrial node cell development  (IEA,ISO)
skeletal system development  (IEA,ISO,ISS)
smooth muscle cell differentiation  (IEA,ISO)
specification of animal organ position  (IEA,ISO)
stem cell population maintenance  (IEA,ISO)
stem cell proliferation  (IEA,ISO)
ureteric peristalsis  (IEA,ISO)
ventricular septum morphogenesis  (IEA,ISO)

Cellular Component
chromatin  (IBA)
cilium  (IEA,ISO)
nucleus  (IBA,IEA,ISO,ISS)
transcription regulator complex  (ISO)

References

References - curated
# Reference Title Reference Citation
1. The ulnar-mammary syndrome gene, Tbx3, is a direct target of the retinoic acid signaling pathway, which regulates its expression during mouse limb development. Ballim RD, etal., Mol Biol Cell. 2012 Jun;23(12):2362-72. doi: 10.1091/mbc.E11-09-0790. Epub 2012 Apr 25.
2. The spectrum of mutations in TBX3: Genotype/Phenotype relationship in ulnar-mammary syndrome. Bamshad M, etal., Am J Hum Genet. 1999 Jun;64(6):1550-62.
3. Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome. Bamshad M, etal., Nat Genet 1997 Jul;16(3):311-5.
4. Msx1 and Msx2 are functional interacting partners of T-box factors in the regulation of Connexin43. Boogerd KJ, etal., Cardiovasc Res. 2008 Jun 1;78(3):485-93. doi: 10.1093/cvr/cvn049. Epub 2008 Feb 19.
5. Estrogen receptor alpha supports cardiomyocytes indirectly through post-infarct cardiac c-kit+ cells. Brinckmann M, etal., J Mol Cell Cardiol. 2009 Jul;47(1):66-75. Epub 2009 Mar 31.
6. T-box Transcription Factor Tbx3 Contributes to Human Hepatocellular Carcinoma Cell Migration and Invasion by Repressing E-Cadherin Expression. Feng X, etal., Oncol Res. 2018 Jul 5;26(6):959-966. doi: 10.3727/096504017X15145624664031. Epub 2018 Jan 2.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Down-regulation of β-catenin and the associated migration ability by Taiwanin C in arecoline and 4-NQO-induced oral cancer cells via GSK-3β activation. Hsieh CH, etal., Mol Carcinog. 2017 Mar;56(3):1055-1067. doi: 10.1002/mc.22570. Epub 2016 Oct 4.
10. Tbx3 expression is related to apoptosis and cell proliferation in rat bladder both hyperplastic epithelial cells and carcinoma cells. Ito A, etal., Cancer Lett. 2005 Feb 28;219(1):105-12.
11. Wnt-pathway activation in two molecular classes of hepatocellular carcinoma and experimental modulation by sorafenib. Lachenmayer A, etal., Clin Cancer Res. 2012 Sep 15;18(18):4997-5007. doi: 10.1158/1078-0432.CCR-11-2322. Epub 2012 Jul 18.
12. Expression of TBX3 in Hepatocellular Carcinoma and Its Clinical Implication. Li Z, etal., Med Sci Monit. 2018 Dec 22;24:9324-9333. doi: 10.12659/MSM.909378.
13. TBX3 functions as a tumor suppressor downstream of activated CTNNB1 mutants during hepatocarcinogenesis. Liang B, etal., J Hepatol. 2021 Jul;75(1):120-131. doi: 10.1016/j.jhep.2021.01.044. Epub 2021 Feb 10.
14. The T-box repressors TBX2 and TBX3 specifically regulate the tumor suppressor gene p14ARF via a variant T-site in the initiator. Lingbeek ME, etal., J Biol Chem 2002 Jul 19;277(29):26120-7. Epub 2002 May 08.
15. Tbx3 overexpression in human gastric cancer is correlated with advanced tumor stage and nodal status and promotes cancer cell growth and invasion. Miao ZF, etal., Virchows Arch. 2016 Nov;469(5):505-513. doi: 10.1007/s00428-016-2007-9. Epub 2016 Aug 24.
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Comprehensive gene review and curation RGD comprehensive gene curation
21. Overexpression of Tbx3 is correlated with Epithelial-Mesenchymal Transition phenotype and predicts poor prognosis of colorectal cancer. Shan ZZ, etal., Am J Cancer Res. 2014 Dec 15;5(1):344-53. eCollection 2015.
22. Proteomics success story. Towards early detection of breast and ovarian cancer: plasma proteomics as a tool to find novel markers. Souchelnytskyi S, etal., Proteomics. 2006 Sep;6 Suppl 2:65-8.
23. [Inhibitory effect of Biejiajian pills on HepG2 cell xenograft growth and expression of β-catenin and Tbx3 in nude mice]. Wen B, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2016 Feb;36(2):210-4.
Additional References at PubMed
PMID:10468588   PMID:11689487   PMID:11748239   PMID:12032820   PMID:12116211   PMID:12668638   PMID:16222716   PMID:17071745   PMID:17234970   PMID:17460765   PMID:17473172   PMID:18356246  
PMID:18467625   PMID:18534921   PMID:18723448   PMID:19096026   PMID:19765559   PMID:19769959   PMID:22002537   PMID:22164283   PMID:23844108   PMID:30478225  


Genomics

Comparative Map Data
Tbx3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81242,540,378 - 42,555,490 (-)NCBIGRCr8
mRatBN7.21236,879,924 - 36,894,849 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1236,881,445 - 36,893,708 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1238,058,977 - 38,070,162 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01238,672,813 - 38,684,003 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01237,725,254 - 37,736,439 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01242,479,518 - 42,494,588 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1242,480,560 - 42,492,526 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01244,326,928 - 44,342,670 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41238,155,494 - 38,166,670 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11238,018,881 - 38,030,058 (-)NCBI
Celera1238,555,497 - 38,566,664 (-)NCBICelera
Cytogenetic Map12q16NCBI
TBX3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812114,670,255 - 114,684,175 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12114,670,255 - 114,684,175 (-)EnsemblGRCh38hg38GRCh38
GRCh3712115,108,060 - 115,121,980 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612113,592,442 - 113,606,352 (-)NCBINCBI36Build 36hg18NCBI36
Build 3412113,570,778 - 113,584,689NCBI
Celera12114,735,560 - 114,749,458 (-)NCBICelera
Cytogenetic Map12q24.21NCBI
HuRef12112,116,904 - 112,130,825 (-)NCBIHuRef
CHM1_112115,075,996 - 115,089,899 (-)NCBICHM1_1
T2T-CHM13v2.012114,647,343 - 114,661,251 (-)NCBIT2T-CHM13v2.0
Tbx3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395119,808,600 - 119,822,789 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5119,808,734 - 119,822,789 (+)EnsemblGRCm39 Ensembl
GRCm385119,670,534 - 119,684,724 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5119,670,669 - 119,684,724 (+)EnsemblGRCm38mm10GRCm38
MGSCv375120,120,678 - 120,134,610 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365119,931,286 - 119,945,218 (+)NCBIMGSCv36mm8
Celera5116,764,719 - 116,778,686 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map560.34NCBI
Tbx3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545515,988,663 - 16,000,063 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545515,988,153 - 16,000,156 (+)NCBIChiLan1.0ChiLan1.0
TBX3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210122,724,799 - 122,741,407 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112122,721,192 - 122,735,426 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012112,240,050 - 112,254,299 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112115,618,420 - 115,632,327 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12115,620,002 - 115,631,316 (-)Ensemblpanpan1.1panPan2
TBX3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12611,694,885 - 11,709,594 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2611,696,565 - 11,708,918 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2611,753,296 - 11,767,965 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02611,953,157 - 11,967,841 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2611,954,731 - 11,966,470 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12611,914,521 - 11,929,199 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02611,977,110 - 11,991,787 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02612,026,728 - 12,041,404 (-)NCBIUU_Cfam_GSD_1.0
Tbx3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118152,235,738 - 152,248,370 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365587,230,668 - 7,244,361 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365587,230,361 - 7,243,651 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TBX3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1437,582,822 - 37,596,766 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11437,582,704 - 37,596,767 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21440,012,569 - 40,026,314 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TBX3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111109,952,100 - 109,966,328 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11109,952,054 - 109,965,065 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037135,142,552 - 135,156,757 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tbx3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474718,128,028 - 18,142,451 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474718,128,003 - 18,142,366 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tbx3
77 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:101
Count of miRNA genes:84
Interacting mature miRNAs:88
Transcripts:ENSRNOT00000011552
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121983578938193007Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122308134044726024Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123210317445899022Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1556747Calcic1Intracellular calcium level QTL 13.6platelet calcium amount (VT:0010500)platelet intracellular calcium level (CMO:0000922)122806443340130419Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)122806443345899022Rat
631829Alc6Alcohol consumption QTL 64.7consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)122860752637691617Rat
8693658Alc33Alcohol consumption QTL 332.10.68drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122308134043551788Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)122806455740218380Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat

Markers in Region
AU047822  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81242,543,200 - 42,543,481 (+)Marker Load Pipeline
mRatBN7.21236,882,747 - 36,883,028 (+)MAPPERmRatBN7.2
Rnor_6.01242,482,341 - 42,482,621NCBIRnor6.0
Rnor_5.01244,329,751 - 44,330,031UniSTSRnor5.0
RGSC_v3.41238,156,683 - 38,156,963UniSTSRGSC3.4
Celera1238,556,680 - 38,556,962UniSTS
Cytogenetic Map12q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000011552   ⟹   ENSRNOP00000011552
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1236,881,445 - 36,893,708 (-)Ensembl
Rnor_6.0 Ensembl1242,481,152 - 42,492,328 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000084018   ⟹   ENSRNOP00000074567
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1236,881,445 - 36,893,708 (-)Ensembl
Rnor_6.0 Ensembl1242,480,560 - 42,492,526 (-)Ensembl
RefSeq Acc Id: NM_181638   ⟹   NP_853669
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81242,540,378 - 42,554,171 (-)NCBI
mRatBN7.21236,879,924 - 36,893,720 (-)NCBI
Rnor_6.01242,481,152 - 42,492,328 (-)NCBI
Rnor_5.01244,326,928 - 44,342,670 (-)NCBI
RGSC_v3.41238,155,494 - 38,166,670 (-)RGD
Celera1238,555,497 - 38,566,664 (-)RGD
Sequence:
RefSeq Acc Id: XM_006249416   ⟹   XP_006249478
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81242,540,378 - 42,555,410 (-)NCBI
mRatBN7.21236,879,924 - 36,894,849 (-)NCBI
Rnor_6.01242,479,518 - 42,494,588 (-)NCBI
Rnor_5.01244,326,928 - 44,342,670 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006249417   ⟹   XP_006249479
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81242,540,378 - 42,554,501 (-)NCBI
mRatBN7.21236,879,924 - 36,894,053 (-)NCBI
Rnor_6.01242,479,518 - 42,493,644 (-)NCBI
Rnor_5.01244,326,928 - 44,342,670 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006249418   ⟹   XP_006249480
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81242,540,378 - 42,555,391 (-)NCBI
mRatBN7.21236,879,924 - 36,894,053 (-)NCBI
Rnor_6.01242,479,518 - 42,493,600 (-)NCBI
Rnor_5.01244,326,928 - 44,342,670 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063271422   ⟹   XP_063127492
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81242,540,378 - 42,554,580 (-)NCBI
RefSeq Acc Id: XM_063271423   ⟹   XP_063127493
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81242,540,378 - 42,555,490 (-)NCBI
RefSeq Acc Id: NP_853669   ⟸   NM_181638
- UniProtKB: Q7TST9 (UniProtKB/Swiss-Prot),   A6J1K4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249478   ⟸   XM_006249416
- Peptide Label: isoform X1
- UniProtKB: Q7TST9 (UniProtKB/Swiss-Prot),   A6J1K4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249479   ⟸   XM_006249417
- Peptide Label: isoform X1
- UniProtKB: Q7TST9 (UniProtKB/Swiss-Prot),   A6J1K4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249480   ⟸   XM_006249418
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K8D7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000011552   ⟸   ENSRNOT00000011552
Ensembl Acc Id: ENSRNOP00000074567   ⟸   ENSRNOT00000084018
RefSeq Acc Id: XP_063127493   ⟸   XM_063271423
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K8D7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127492   ⟸   XM_063271422
- Peptide Label: isoform X1
- UniProtKB: Q7TST9 (UniProtKB/Swiss-Prot),   A6J1K4 (UniProtKB/TrEMBL)
Protein Domains
T-box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TST9-F1-model_v2 AlphaFold Q7TST9 1-743 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735203 AgrOrtholog
BioCyc Gene G2FUF-19147 BioCyc
Ensembl Genes ENSRNOG00000008706 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000011552 ENTREZGENE
  ENSRNOT00000011552.5 UniProtKB/Swiss-Prot
  ENSRNOT00000084018 ENTREZGENE
Gene3D-CATH 2.60.40.820 UniProtKB/Swiss-Prot
InterPro p53-like_TF_DNA-bd UniProtKB/Swiss-Prot
  T-box_DNA-bd UniProtKB/Swiss-Prot
  T-box_sf UniProtKB/Swiss-Prot
  TBX UniProtKB/Swiss-Prot
  TBX2_3_RD UniProtKB/Swiss-Prot
  TF_T-box UniProtKB/Swiss-Prot
  TF_T-box_CS UniProtKB/Swiss-Prot
KEGG Report rno:353305 UniProtKB/Swiss-Prot
NCBI Gene 353305 ENTREZGENE
PANTHER PTHR11267 UniProtKB/Swiss-Prot
  T-BOX TRANSCRIPTION FACTOR TBX3 UniProtKB/Swiss-Prot
Pfam T-box UniProtKB/Swiss-Prot
  TBX UniProtKB/Swiss-Prot
  TBX2-3_RD UniProtKB/Swiss-Prot
PhenoGen Tbx3 PhenoGen
PRINTS TBOX UniProtKB/Swiss-Prot
PROSITE TBOX_1 UniProtKB/Swiss-Prot
  TBOX_2 UniProtKB/Swiss-Prot
  TBOX_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000008706 RatGTEx
SMART TBOX UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49417 UniProtKB/Swiss-Prot
UniProt A0A0G2K8D7 ENTREZGENE, UniProtKB/TrEMBL
  A6J1K4 ENTREZGENE, UniProtKB/TrEMBL
  A6J1K5_RAT UniProtKB/TrEMBL
  A6J1K6_RAT UniProtKB/TrEMBL
  Q7TST9 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-05 Tbx3  T-box transcription factor 3  Tbx3  T-box 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Tbx3  T-box 3    T-box 3 (ulnar mammary syndrome)  Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mutation of the human homolog causes ulnar-mammary syndrome, which is characterized by defects in limb, apocrine gland, tooth and genital development 1302838