Pcdha2 (protocadherin alpha 2) - Rat Genome Database

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Gene: Pcdha2 (protocadherin alpha 2) Rattus norvegicus
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Symbol: Pcdha2
Name: protocadherin alpha 2
RGD ID: 735182
Description: Predicted to enable calcium ion binding activity. Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be located in endoplasmic reticulum and nucleus. Orthologous to human PCDHA2 (protocadherin alpha 2); INTERACTS WITH 17alpha-ethynylestradiol; bisphenol A; 5-azacytidine (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cadherin-related neuronal receptor 2; protocadherin alpha-2; rCNRv02
RGD Orthologs
Human
Mouse
Bonobo
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
NCBI Annotation Information: Genome Annotation Status: not in current annotation release
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2 Ensembl1828,581,225 - 28,846,211 (+)EnsemblmRatBN7.2
Rnor_6.01829,960,072 - 30,215,896 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01829,657,322 - 29,924,443 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41829,670,538 - 29,928,030 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1828,298,905 - 28,552,754 (+)NCBICelera
RGSC_v3.11829,697,183 - 29,954,676 (+)NCBI
Cytogenetic Map18p11NCBI




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Genomic sequence and organization of the family of CNR/Pcdhalpha genes in rat. Yanase H, etal., Genomics 2004 Apr;83(4):717-26.
Additional References at PubMed
PMID:11401448   PMID:14672974   PMID:15347688   PMID:15744052   PMID:17110050  


Genomics

Comparative Map Data
Pcdha2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2 Ensembl1828,581,225 - 28,846,211 (+)EnsemblmRatBN7.2
Rnor_6.01829,960,072 - 30,215,896 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01829,657,322 - 29,924,443 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41829,670,538 - 29,928,030 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1828,298,905 - 28,552,754 (+)NCBICelera
RGSC_v3.11829,697,183 - 29,954,676 (+)NCBI
Cytogenetic Map18p11NCBI
PCDHA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385140,794,852 - 141,012,347 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5140,794,852 - 141,012,347 (+)Ensemblhg38GRCh38
GRCh375140,174,437 - 140,391,932 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365140,154,628 - 140,372,113 (+)NCBIBuild 36Build 36hg18NCBI36
Build 345140,154,627 - 140,165,386NCBI
Celera5136,251,221 - 136,468,708 (+)NCBICelera
Cytogenetic Map5q31.3NCBI
HuRef5135,319,158 - 135,536,628 (+)NCBIHuRef
CHM1_15139,607,636 - 139,825,092 (+)NCBICHM1_1
T2T-CHM13v2.05141,320,185 - 141,537,634 (+)NCBIT2T-CHM13v2.0
Pcdha2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391837,072,258 - 37,320,714 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1837,072,258 - 37,320,710 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381836,939,205 - 37,187,661 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1836,939,205 - 37,187,657 (+)Ensemblmm10GRCm38
MGSCv371837,098,859 - 37,347,315 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361837,065,292 - 37,313,631 (+)NCBIMGSCv36mm8
MGSCv361837,126,424 - 37,374,763 (+)NCBIMGSCv36mm8
Celera1837,385,976 - 37,388,476 (+)NCBICelera
Cytogenetic Map18B2- B3NCBI
cM Map1819.46NCBI
LOC100994239
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15142,274,257 - 142,276,995 (+)NCBIPanPan1.1PanPan1.1panPan2

Markers in Region
WI-19540  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21828,845,892 - 28,846,156 (+)MAPPERmRatBN7.2
Rnor_6.01830,215,579 - 30,215,842NCBIRnor6.0
Rnor_5.01829,924,126 - 29,924,389UniSTSRnor5.0
RGSC_v3.41829,927,713 - 29,927,976UniSTSRGSC3.4
Celera1828,552,437 - 28,552,700UniSTS
Cytogenetic Map18p11UniSTS
RH65516  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21828,845,204 - 28,845,379 (+)MAPPERmRatBN7.2
Rnor_6.01830,214,891 - 30,215,065NCBIRnor6.0
Rnor_5.01829,923,438 - 29,923,612UniSTSRnor5.0
RGSC_v3.41829,927,025 - 29,927,199UniSTSRGSC3.4
Celera1828,551,749 - 28,551,923UniSTS
Cytogenetic Map18p11UniSTS
IB766  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21828,845,918 - 28,846,149 (+)MAPPERmRatBN7.2
Rnor_6.01830,215,605 - 30,215,835NCBIRnor6.0
Rnor_5.01829,924,152 - 29,924,382UniSTSRnor5.0
RGSC_v3.41829,927,739 - 29,927,969UniSTSRGSC3.4
Celera1828,552,463 - 28,552,693UniSTS
Cytogenetic Map18p11UniSTS
PMC311048P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21828,818,659 - 28,818,748 (+)MAPPERmRatBN7.2
Rnor_6.01830,188,352 - 30,188,440NCBIRnor6.0
Rnor_5.01829,896,899 - 29,896,987UniSTSRnor5.0
RGSC_v3.41829,900,486 - 29,900,574UniSTSRGSC3.4
Celera1828,525,314 - 28,525,402UniSTS
Cytogenetic Map18p11UniSTS
RH91795  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21828,843,505 - 28,843,650 (+)MAPPERmRatBN7.2
Rnor_6.01830,213,192 - 30,213,336NCBIRnor6.0
Rnor_5.01829,921,739 - 29,921,883UniSTSRnor5.0
RGSC_v3.41829,925,326 - 29,925,470UniSTSRGSC3.4
Celera1828,550,050 - 28,550,194UniSTS
Cytogenetic Map18p11UniSTS
BF389688  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21828,749,911 - 28,750,152 (+)MAPPERmRatBN7.2
Rnor_6.01830,119,568 - 30,119,808NCBIRnor6.0
Rnor_5.01829,815,629 - 29,815,869UniSTSRnor5.0
RGSC_v3.41829,831,514 - 29,831,754UniSTSRGSC3.4
Celera1828,458,199 - 28,458,439UniSTS
RH 3.4 Map18420.79UniSTS
Cytogenetic Map18p11UniSTS
PMC311048P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21828,641,804 - 28,641,941 (+)MAPPERmRatBN7.2
Rnor_6.01830,011,467 - 30,011,603NCBIRnor6.0
Rnor_5.01829,708,717 - 29,708,853UniSTSRnor5.0
RGSC_v3.41829,722,152 - 29,722,288UniSTSRGSC3.4
Celera1828,350,300 - 28,350,436UniSTS
Cytogenetic Map18p11UniSTS
PMC312645P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21828,843,709 - 28,843,897 (+)MAPPERmRatBN7.2
Rnor_6.01830,213,396 - 30,213,583NCBIRnor6.0
Rnor_5.01829,921,943 - 29,922,130UniSTSRnor5.0
RGSC_v3.41829,925,530 - 29,925,717UniSTSRGSC3.4
Celera1828,550,254 - 28,550,441UniSTS
Cytogenetic Map18p11UniSTS
UniSTS:547524  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21828,843,567 - 28,844,209 (+)MAPPERmRatBN7.2
Rnor_6.01830,213,254 - 30,213,895NCBIRnor6.0
Rnor_5.01829,921,801 - 29,922,442UniSTSRnor5.0
Celera1828,550,112 - 28,550,753UniSTS
Cytogenetic Map18p11UniSTS


Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: NM_199504   ⟹   NP_955798
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01829,960,072 - 30,215,896 (+)NCBI
Rnor_5.01829,657,322 - 29,924,443 (+)NCBI
RGSC_v3.41829,670,538 - 29,928,030 (+)RGD
Celera1828,298,905 - 28,552,754 (+)RGD
Protein Sequences
Protein RefSeqs NP_955798 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAT77558 (Get FASTA)   NCBI Sequence Viewer  
  BAD06367 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000065957.2
  ENSRNOP00000066774.3
RefSeq Acc Id: NP_955798   ⟸   NM_199504
- Peptide Label: precursor
- UniProtKB: Q767J0 (UniProtKB/TrEMBL),   M0R8Z9 (UniProtKB/TrEMBL),   A0A8J8XGC7 (UniProtKB/TrEMBL)
Protein Domains
Cadherin

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735182 AgrOrtholog
Ensembl Genes ENSRNOG00000020119 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000071366.2 UniProtKB/TrEMBL
  ENSRNOT00000075810.3 UniProtKB/TrEMBL
Gene3D-CATH Cadherins UniProtKB/TrEMBL
InterPro Cadherin UniProtKB/TrEMBL
  Cadherin-like UniProtKB/TrEMBL
  Cadherin_CBD UniProtKB/TrEMBL
  Cadherin_CS UniProtKB/TrEMBL
  Cadherin_N UniProtKB/TrEMBL
  Protocadherin/Cadherin-CA UniProtKB/TrEMBL
NCBI Gene 393086 ENTREZGENE
PANTHER CADHERIN-87A UniProtKB/TrEMBL
  PROTOCADHERIN ALPHA-2 UniProtKB/TrEMBL
Pfam Cadherin UniProtKB/TrEMBL
  Cadherin_2 UniProtKB/TrEMBL
  Cadherin_tail UniProtKB/TrEMBL
PhenoGen Pcdha2 PhenoGen
PRINTS CADHERIN UniProtKB/TrEMBL
PROSITE CADHERIN_1 UniProtKB/TrEMBL
  CADHERIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020119 RatGTEx
SMART SM00112 UniProtKB/TrEMBL
Superfamily-SCOP Cadherin UniProtKB/TrEMBL
UniProt A0A8J8XGC7 ENTREZGENE, UniProtKB/TrEMBL
  M0R8Z9 ENTREZGENE
  Q767J0 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary M0R8Z9 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-10-12 Pcdha2        Symbol and Name status set to provisional 70820 PROVISIONAL
2005-04-20   protocadherin alpha 2  Pcdha2  cadherin-related neuronal receptor 2  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED