Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Chdh | Rat | 17beta-estradiol | increases expression | ISO | CHDH (Homo sapiens) | 6480464 | Estradiol results in increased expression of CHDH mRNA | CTD | PMID:23019147 and PMID:31614463 | Chdh | Rat | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of CHDH mRNA and Estradiol results in decreased expression of CHDH protein | CTD | PMID:32145629 | Chdh | Rat | 17beta-estradiol | decreases expression | ISO | Chdh (Mus musculus) | 6480464 | Estradiol results in decreased expression of CHDH mRNA | CTD | PMID:19484750 | Chdh | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | CHDH (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin affects the expression of CHDH mRNA | CTD | PMID:22298810 | Chdh | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Chdh (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of CHDH mRNA | CTD | PMID:33956508 | Chdh | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of CHDH mRNA | CTD | PMID:32109520 | Chdh | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Chdh (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of CHDH mRNA | CTD | PMID:25975270 | Chdh | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Chdh (Mus musculus) | 6480464 | [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of CHDH mRNA | CTD | PMID:25975270 | Chdh | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Chdh (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of CHDH mRNA | CTD | PMID:18343893 and PMID:21570461 | Chdh | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of CHDH mRNA | CTD | PMID:22298810 | Chdh | Rat | 2,3,7,8-Tetrachlorodibenzofuran | affects expression | ISO | Chdh (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:18343893 | Chdh | Rat | 2,4-dibromophenyl 2,4,5-tribromophenyl ether | affects expression | ISO | Chdh (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:38648751 | Chdh | Rat | 4,4'-sulfonyldiphenol | decreases methylation | ISO | CHDH (Homo sapiens) | 6480464 | bisphenol S results in decreased methylation of CHDH gene | CTD | PMID:31601247 | Chdh | Rat | 4,4'-sulfonyldiphenol | affects methylation | ISO | Chdh (Mus musculus) | 6480464 | bisphenol S affects the methylation of CHDH gene | CTD | PMID:31683443 | Chdh | Rat | 4-hydroxyphenyl retinamide | increases expression | ISO | Chdh (Mus musculus) | 6480464 | Fenretinide results in increased expression of CHDH mRNA | CTD | PMID:28973697 | Chdh | Rat | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of CHDH mRNA | CTD | PMID:24780913 | Chdh | Rat | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of CHDH mRNA | CTD | PMID:30047161 | Chdh | Rat | acetamide | decreases expression | EXP | | 6480464 | acetamide results in decreased expression of CHDH mRNA | CTD | PMID:31881176 | Chdh | Rat | acrylamide | increases expression | EXP | | 6480464 | Acrylamide results in increased expression of CHDH mRNA | CTD | PMID:28959563 | Chdh | Rat | aflatoxin B1 | decreases expression | ISO | CHDH (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased expression of CHDH mRNA | CTD | PMID:27153756 | Chdh | Rat | all-trans-retinoic acid | decreases expression | ISO | CHDH (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of CHDH mRNA | CTD | PMID:23724009 | Chdh | Rat | amitrole | decreases expression | EXP | | 6480464 | Amitrole results in decreased expression of CHDH mRNA | CTD | PMID:30047161 | Chdh | Rat | arsane | affects metabolic processing | ISO | CHDH (Homo sapiens) | 6480464 | CHDH protein affects the metabolism of Arsenic | CTD | PMID:18682255 | Chdh | Rat | arsenic atom | affects metabolic processing | ISO | CHDH (Homo sapiens) | 6480464 | CHDH protein affects the metabolism of Arsenic | CTD | PMID:18682255 | Chdh | Rat | benzo[a]pyrene | multiple interactions | ISO | Chdh (Mus musculus) | 6480464 | Benzo(a)pyrene promotes the reaction [AHR protein binds to CHDH promoter] | CTD | PMID:19654925 | Chdh | Rat | benzo[a]pyrene | increases methylation | ISO | CHDH (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of CHDH 3' UTR and Benzo(a)pyrene results in increased methylation of CHDH promoter | CTD | PMID:27901495 | Chdh | Rat | benzo[a]pyrene | increases expression | ISO | Chdh (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of CHDH mRNA | CTD | PMID:22228805 and PMID:27195522 | Chdh | Rat | beta-naphthoflavone | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CHDH mRNA | CTD | PMID:18164116 | Chdh | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of CHDH mRNA and bisphenol A results in decreased expression of CHDH protein | CTD | PMID:25181051 and PMID:32145629 | Chdh | Rat | bisphenol A | increases expression | ISO | Chdh (Mus musculus) | 6480464 | bisphenol A results in increased expression of CHDH mRNA | CTD | PMID:32156529 | Chdh | Rat | bisphenol A | multiple interactions | ISO | CHDH (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of CHDH gene | CTD | PMID:31601247 | Chdh | Rat | bisphenol A | affects expression | ISO | CHDH (Homo sapiens) | 6480464 | bisphenol A affects the expression of CHDH mRNA | CTD | PMID:30903817 | Chdh | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of CHDH mRNA | CTD | PMID:30816183 and PMID:32528016 | Chdh | Rat | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of CHDH gene | CTD | PMID:28505145 | Chdh | Rat | cadmium dichloride | increases expression | ISO | CHDH (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of CHDH mRNA | CTD | PMID:38568856 | Chdh | Rat | calcitriol | increases expression | ISO | CHDH (Homo sapiens) | 6480464 | Calcitriol results in increased expression of CHDH mRNA | CTD | PMID:26485663 | Chdh | Rat | carbamazepine | affects expression | ISO | CHDH (Homo sapiens) | 6480464 | Carbamazepine affects the expression of CHDH mRNA | CTD | PMID:24752500 | Chdh | Rat | CGP 52608 | multiple interactions | ISO | CHDH (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to CHDH gene] | CTD | PMID:28238834 | Chdh | Rat | chlorpyrifos | decreases expression | ISO | Chdh (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of CHDH mRNA | CTD | PMID:37019170 | Chdh | Rat | choline | affects response to substance | ISO | CHDH (Homo sapiens) | 6480464 | CHDH gene SNP affects the susceptibility to Choline | CTD | PMID:17616785 | Chdh | Rat | cisplatin | decreases expression | ISO | CHDH (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of CHDH mRNA | CTD | PMID:27392435 | Chdh | Rat | cobalt atom | increases expression | ISO | Chdh (Mus musculus) | 6480464 | Cobalt results in increased expression of CHDH mRNA | CTD | PMID:34468815 | Chdh | Rat | cobalt dichloride | decreases expression | EXP | | 6480464 | cobaltous chloride results in decreased expression of CHDH mRNA | CTD | PMID:24386269 | Chdh | Rat | copper atom | decreases expression | EXP | | 6480464 | Copper results in decreased expression of CHDH mRNA | CTD | PMID:22465980 | Chdh | Rat | copper atom | multiple interactions | ISO | CHDH (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of CHDH mRNA | CTD | PMID:20971185 | Chdh | Rat | copper(0) | decreases expression | EXP | | 6480464 | Copper results in decreased expression of CHDH mRNA | CTD | PMID:22465980 | Chdh | Rat | copper(0) | multiple interactions | ISO | CHDH (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of CHDH mRNA | CTD | PMID:20971185 | Chdh | Rat | copper(II) sulfate | decreases expression | ISO | CHDH (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of CHDH mRNA | CTD | PMID:19549813 | Chdh | Rat | Cuprizon | decreases expression | EXP | | 6480464 | Cuprizone results in decreased expression of CHDH mRNA | CTD | PMID:27523638 | Chdh | Rat | cyclosporin A | decreases expression | ISO | Chdh (Mus musculus) | 6480464 | Cyclosporine results in decreased expression of CHDH mRNA | CTD | PMID:19770486 | Chdh | Rat | cyclosporin A | decreases expression | ISO | CHDH (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of CHDH mRNA | CTD | PMID:25562108 | Chdh | Rat | dichloroacetic acid | increases expression | ISO | Chdh (Mus musculus) | 6480464 | Dichloroacetic Acid results in increased expression of CHDH mRNA | CTD | PMID:28962523 | Chdh | Rat | diclofenac | affects expression | ISO | CHDH (Homo sapiens) | 6480464 | Diclofenac affects the expression of CHDH mRNA | CTD | PMID:24752500 | Chdh | Rat | dorsomorphin | multiple interactions | ISO | CHDH (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CHDH mRNA | CTD | PMID:27188386 | Chdh | Rat | epoxiconazole | decreases expression | ISO | Chdh (Mus musculus) | 6480464 | epoxiconazole results in decreased expression of CHDH mRNA | CTD | PMID:35436446 | Chdh | Rat | ethanol | increases expression | EXP | | 6480464 | Ethanol results in increased expression of CHDH mRNA | CTD | PMID:15353170 | Chdh | Rat | ethanol | affects expression | ISO | Chdh (Mus musculus) | 6480464 | Ethanol affects the expression of CHDH mRNA | CTD | PMID:30319688 | Chdh | Rat | formaldehyde | decreases expression | ISO | CHDH (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of CHDH mRNA | CTD | PMID:23649840 | Chdh | Rat | fulvestrant | multiple interactions | ISO | CHDH (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of CHDH gene | CTD | PMID:31601247 | Chdh | Rat | lead diacetate | increases expression | ISO | Chdh (Mus musculus) | 6480464 | lead acetate results in increased expression of CHDH mRNA | CTD | PMID:22613225 | Chdh | Rat | lead(0) | affects expression | ISO | CHDH (Homo sapiens) | 6480464 | Lead affects the expression of CHDH mRNA | CTD | PMID:28903495 | Chdh | Rat | leflunomide | decreases expression | ISO | CHDH (Homo sapiens) | 6480464 | leflunomide results in decreased expression of CHDH mRNA | CTD | PMID:28988120 and PMID:29427785 | Chdh | Rat | methimazole | decreases expression | EXP | | 6480464 | Methimazole results in decreased expression of CHDH mRNA | CTD | PMID:30047161 | Chdh | Rat | methyl methanesulfonate | decreases expression | ISO | CHDH (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in decreased expression of CHDH mRNA | CTD | PMID:23649840 | Chdh | Rat | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CHDH mRNA | CTD | PMID:18164116 | Chdh | Rat | nickel atom | decreases expression | ISO | CHDH (Homo sapiens) | 6480464 | Nickel results in decreased expression of CHDH mRNA | CTD | PMID:24768652 and PMID:25583101 | Chdh | Rat | paracetamol | affects expression | ISO | Chdh (Mus musculus) | 6480464 | Acetaminophen affects the expression of CHDH mRNA | CTD | PMID:17562736 | Chdh | Rat | paracetamol | decreases expression | ISO | CHDH (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of CHDH mRNA | CTD | PMID:25704631 and PMID:26690555 | Chdh | Rat | paraquat | decreases expression | EXP | | 6480464 | Paraquat results in decreased expression of CHDH mRNA | CTD | PMID:32680482 | Chdh | Rat | perfluorooctanoic acid | decreases expression | ISO | CHDH (Homo sapiens) | 6480464 | perfluorooctanoic acid results in decreased expression of CHDH protein | CTD | PMID:26879310 | Chdh | Rat | phenobarbital | decreases expression | EXP | | 6480464 | Phenobarbital results in decreased expression of CHDH mRNA | CTD | PMID:19162173 | Chdh | Rat | pirinixic acid | increases expression | ISO | Chdh (Mus musculus) | 6480464 | pirinixic acid results in increased expression of CHDH mRNA | CTD | PMID:18301758 and PMID:23811191 | Chdh | Rat | rotenone | decreases expression | EXP | | 6480464 | Rotenone results in decreased expression of CHDH mRNA | CTD | PMID:28374803 | Chdh | Rat | rotenone | increases expression | EXP | | 6480464 | Rotenone results in increased expression of CHDH protein | CTD | PMID:35544339 | Chdh | Rat | SB 431542 | multiple interactions | ISO | CHDH (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CHDH mRNA | CTD | PMID:27188386 | Chdh | Rat | sodium arsenite | decreases expression | ISO | Chdh (Mus musculus) | 6480464 | sodium arsenite results in decreased expression of CHDH protein | CTD | PMID:29044176 | Chdh | Rat | sodium arsenite | decreases expression | ISO | CHDH (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of CHDH mRNA | CTD | PMID:38568856 | Chdh | Rat | sodium arsenite | increases expression | EXP | | 6480464 | sodium arsenite results in increased expression of CHDH protein | CTD | PMID:29459688 | Chdh | Rat | sunitinib | decreases expression | ISO | CHDH (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of CHDH mRNA | CTD | PMID:31533062 | Chdh | Rat | temozolomide | increases expression | ISO | CHDH (Homo sapiens) | 6480464 | Temozolomide results in increased expression of CHDH mRNA | CTD | PMID:31758290 | Chdh | Rat | teriflunomide | decreases expression | ISO | CHDH (Homo sapiens) | 6480464 | teriflunomide results in decreased expression of CHDH mRNA | CTD | PMID:29427785 | Chdh | Rat | tert-butyl hydroperoxide | decreases expression | ISO | CHDH (Homo sapiens) | 6480464 | tert-Butylhydroperoxide results in decreased expression of CHDH mRNA | CTD | PMID:27509014 | Chdh | Rat | tetrachloromethane | decreases expression | ISO | Chdh (Mus musculus) | 6480464 | Carbon Tetrachloride results in decreased expression of CHDH mRNA | CTD | PMID:31919559 | Chdh | Rat | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of CHDH mRNA | CTD | PMID:23411599 and PMID:34492290 | Chdh | Rat | titanium dioxide | decreases expression | ISO | Chdh (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of CHDH mRNA | CTD | PMID:35295148 | Chdh | Rat | triclosan | decreases expression | ISO | CHDH (Homo sapiens) | 6480464 | Triclosan results in decreased expression of CHDH mRNA | CTD | PMID:30510588 | Chdh | Rat | trimellitic anhydride | decreases expression | ISO | Chdh (Mus musculus) | 6480464 | trimellitic anhydride results in decreased expression of CHDH mRNA | CTD | PMID:19042947 | Chdh | Rat | troglitazone | decreases expression | ISO | Chdh (Mus musculus) | 6480464 | troglitazone results in decreased expression of CHDH protein | CTD | PMID:18495193 | Chdh | Rat | urethane | decreases expression | ISO | CHDH (Homo sapiens) | 6480464 | Urethane results in decreased expression of CHDH mRNA | CTD | PMID:28818685 | Chdh | Rat | valdecoxib | decreases expression | EXP | | 6480464 | valdecoxib results in decreased expression of CHDH mRNA | CTD | PMID:24136188 | Chdh | Rat | valproic acid | affects expression | ISO | Chdh (Mus musculus) | 6480464 | Valproic Acid affects the expression of CHDH mRNA | CTD | PMID:17292431 | Chdh | Rat | valproic acid | decreases expression | ISO | CHDH (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of CHDH mRNA | CTD | PMID:26272509 | Chdh | Rat | valproic acid | multiple interactions | ISO | CHDH (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CHDH mRNA | CTD | PMID:27188386 | |