Sfrp2 (secreted frizzled-related protein 2) - Rat Genome Database

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Gene: Sfrp2 (secreted frizzled-related protein 2) Rattus norvegicus
Analyze
Symbol: Sfrp2
Name: secreted frizzled-related protein 2
RGD ID: 735163
Description: Predicted to enable several functions, including Wnt-protein binding activity; fibronectin binding activity; and signaling receptor binding activity. Involved in negative regulation of canonical Wnt signaling pathway; positive regulation of canonical Wnt signaling pathway; and response to nutrient. Predicted to be located in collagen-containing extracellular matrix. Predicted to be active in extracellular space. Biomarker of myocardial infarction. Orthologous to human SFRP2 (secreted frizzled related protein 2); PARTICIPATES IN Wnt signaling, canonical pathway; Wnt signaling pathway; INTERACTS WITH 17beta-estradiol; 2-amino-2-deoxy-D-glucopyranose; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: putative secreted frizzled related protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82171,387,536 - 171,395,081 (+)NCBIGRCr8
mRatBN7.22169,089,517 - 169,097,064 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2169,089,517 - 169,097,063 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2176,277,331 - 176,284,893 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02174,297,265 - 174,304,827 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02168,898,730 - 168,906,293 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02182,723,732 - 182,731,277 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2182,723,854 - 182,731,764 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02202,136,233 - 202,143,778 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42175,479,320 - 175,486,865 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12175,435,856 - 175,436,574 (+)NCBI
Celera2163,105,875 - 163,113,424 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
7,12-dimethyltetraphene  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (EXP)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
beta-D-glucosamine  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromochloroacetic acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
CHIR 99021  (ISO)
chlorpyrifos  (EXP,ISO)
chrysene  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
corn oil  (EXP)
cortisol  (ISO)
Cuprizon  (EXP)
curcumin  (EXP)
cyclosporin A  (EXP)
cytarabine  (ISO)
D-glucose  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (EXP)
diiodine  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
fonofos  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (EXP)
glucose  (ISO)
glyphosate  (EXP)
hydrazine  (ISO)
imidacloprid  (EXP)
indole-3-methanol  (EXP)
indometacin  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
losartan  (EXP)
methamphetamine  (EXP)
methylmercury chloride  (ISO)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (EXP)
ochratoxin A  (EXP)
panobinostat  (ISO)
parathion  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
tamoxifen  (ISO)
terbufos  (ISO)
tetraphene  (ISO)
thalidomide  (ISO)
thiabendazole  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
XAV939  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior pattern specification  (ISO)
apoptotic process  (ISO)
BMP signaling pathway  (ISO)
branching involved in blood vessel morphogenesis  (ISO)
canonical Wnt signaling pathway  (IBA,ISO)
cardiac left ventricle morphogenesis  (ISO)
cardiac muscle cell apoptotic process  (ISO)
cartilage development  (ISO)
cell-cell signaling  (ISO)
cellular response to X-ray  (ISO)
chondrocyte development  (ISO)
collagen fibril organization  (ISO)
convergent extension involved in axis elongation  (ISO)
development of primary male sexual characteristics  (ISO)
digestive tract morphogenesis  (ISO)
embryonic digit morphogenesis  (ISO)
hematopoietic stem cell proliferation  (ISO)
male gonad development  (ISO)
mesodermal cell fate specification  (ISO)
negative regulation of BMP signaling pathway  (ISO)
negative regulation of canonical Wnt signaling pathway  (IGI,ISO)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
negative regulation of dermatome development  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of epithelial to mesenchymal transition  (ISO)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
negative regulation of JUN kinase activity  (ISO)
negative regulation of mesodermal cell fate specification  (ISO)
negative regulation of peptidyl-tyrosine phosphorylation  (IEA,ISO)
negative regulation of Wnt signaling pathway  (ISO)
neural tube closure  (ISO)
neural tube development  (ISO)
non-canonical Wnt signaling pathway  (IBA)
obsolete negative regulation of planar cell polarity pathway involved in axis elongation  (ISO)
obsolete planar cell polarity pathway involved in axis elongation  (ISO)
obsolete planar cell polarity pathway involved in neural tube closure  (ISO)
outflow tract morphogenesis  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of canonical Wnt signaling pathway  (IGI,ISO)
positive regulation of cell adhesion mediated by integrin  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of endopeptidase activity  (ISO)
positive regulation of fat cell differentiation  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of peptidyl-serine phosphorylation  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
post-anal tail morphogenesis  (ISO)
regulation of apoptotic process  (ISO)
regulation of cell population proliferation  (ISO)
regulation of establishment of planar polarity  (ISO)
regulation of midbrain dopaminergic neuron differentiation  (ISO)
regulation of neuron projection development  (ISO)
regulation of stem cell division  (ISO)
regulation of Wnt signaling pathway  (ISO)
response to nutrient  (IEP)
response to xenobiotic stimulus  (ISO)
sclerotome development  (ISO)
somitogenesis  (ISO)
stem cell fate specification  (ISO)
Wnt signaling pathway involved in somitogenesis  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The secreted frizzled related protein 2 (SFRP2) gene is a target of the Pax2 transcription factor. Brophy PD, etal., J Biol Chem 2003 Dec 26;278(52):52401-5. Epub 2003 Oct 15.
2. Secreted and transmembrane wnt inhibitors and activators. Cruciat CM and Niehrs C, Cold Spring Harb Perspect Biol. 2013 Mar 1;5(3):a015081. doi: 10.1101/cshperspect.a015081.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction. Kobayashi K, etal., Nat Cell Biol. 2009 Jan;11(1):46-55. doi: 10.1038/ncb1811. Epub 2008 Dec 14.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Expression profiling of rat mammary epithelial cells reveals candidate signaling pathways in dietary protection from mammary tumors. Su Y, etal., Physiol Genomics. 2007 Jun 19;30(1):8-16. Epub 2007 Mar 6.
10. Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/beta-catenin signaling. Xavier CP, etal., Cell Signal. 2014 Jan;26(1):94-101. doi: 10.1016/j.cellsig.2013.09.016. Epub 2013 Sep 28.
11. Secreted frizzled related protein 2 protects cells from apoptosis by blocking the effect of canonical Wnt3a. Zhang Z, etal., J Mol Cell Cardiol. 2009 Mar;46(3):370-7. Epub 2008 Dec 9.
Additional References at PubMed
PMID:9038166   PMID:9391078   PMID:10322635   PMID:10654605   PMID:10980594   PMID:11357136   PMID:12055200   PMID:12477932   PMID:14709558   PMID:16077992   PMID:16467359   PMID:17251350  
PMID:17462603   PMID:17471511   PMID:17804636   PMID:17848950   PMID:18166153   PMID:18257070   PMID:18729207   PMID:19001373   PMID:19095296   PMID:19100252   PMID:19300477   PMID:19458075  
PMID:19593212   PMID:19778523   PMID:19850029   PMID:19896444   PMID:20208569   PMID:20723538   PMID:21078975   PMID:22290867   PMID:27113532   PMID:30291843   PMID:31918758   PMID:38101654  


Genomics

Comparative Map Data
Sfrp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82171,387,536 - 171,395,081 (+)NCBIGRCr8
mRatBN7.22169,089,517 - 169,097,064 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2169,089,517 - 169,097,063 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2176,277,331 - 176,284,893 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02174,297,265 - 174,304,827 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02168,898,730 - 168,906,293 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02182,723,732 - 182,731,277 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2182,723,854 - 182,731,764 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02202,136,233 - 202,143,778 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42175,479,320 - 175,486,865 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12175,435,856 - 175,436,574 (+)NCBI
Celera2163,105,875 - 163,113,424 (+)NCBICelera
Cytogenetic Map2q34NCBI
SFRP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384153,780,591 - 153,789,083 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4153,780,591 - 153,789,083 (-)EnsemblGRCh38hg38GRCh38
GRCh374154,701,743 - 154,710,235 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364154,921,192 - 154,929,678 (-)NCBINCBI36Build 36hg18NCBI36
Build 344155,059,346 - 155,067,833NCBI
Celera4152,026,238 - 152,034,728 (-)NCBICelera
Cytogenetic Map4q31.3NCBI
HuRef4150,432,908 - 150,441,398 (-)NCBIHuRef
CHM1_14154,680,045 - 154,688,529 (-)NCBICHM1_1
T2T-CHM13v2.04157,105,099 - 157,113,596 (-)NCBIT2T-CHM13v2.0
Sfrp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39383,673,628 - 83,681,621 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl383,673,628 - 83,681,623 (+)EnsemblGRCm39 Ensembl
GRCm38383,765,750 - 83,774,314 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl383,766,321 - 83,774,316 (+)EnsemblGRCm38mm10GRCm38
MGSCv37383,570,243 - 83,578,236 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36383,852,248 - 83,860,242 (+)NCBIMGSCv36mm8
Celera383,778,926 - 83,786,923 (+)NCBICelera
Cytogenetic Map3E3NCBI
cM Map337.37NCBI
Sfrp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554718,103,783 - 8,112,321 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554718,103,937 - 8,112,596 (-)NCBIChiLan1.0ChiLan1.0
SFRP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23151,668,957 - 151,682,045 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14152,024,677 - 152,032,604 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04146,123,075 - 146,131,543 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14157,944,733 - 157,953,258 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4157,944,733 - 157,953,258 (-)Ensemblpanpan1.1panPan2
SFRP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11551,541,197 - 51,548,765 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1551,540,500 - 51,548,765 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1551,886,301 - 51,894,431 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01552,226,638 - 52,234,922 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1552,226,643 - 52,235,106 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11551,482,317 - 51,490,435 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01551,588,474 - 51,596,595 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01551,900,564 - 51,908,708 (-)NCBIUU_Cfam_GSD_1.0
Sfrp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530138,934,030 - 38,942,739 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936576604,069 - 613,021 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936576604,174 - 612,440 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SFRP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl875,337,144 - 75,345,921 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1875,337,311 - 75,345,926 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2879,743,347 - 79,751,962 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SFRP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17100,336,442 - 100,345,093 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7100,336,119 - 100,345,086 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603779,988,717 - 79,997,279 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sfrp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248585,052,518 - 5,061,591 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248585,052,736 - 5,061,495 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sfrp2
44 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:101
Count of miRNA genes:80
Interacting mature miRNAs:95
Transcripts:ENSRNOT00000012658
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168354880185122374Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072175950118Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2152413072175950118Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072175950118Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072175950118Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072175950118Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2152413072175950118Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat

Markers in Region
RH141998  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22169,096,834 - 169,097,029 (+)MAPPERmRatBN7.2
Rnor_6.02182,731,048 - 182,731,242NCBIRnor6.0
Rnor_5.02202,143,549 - 202,143,743UniSTSRnor5.0
RGSC_v3.42175,486,636 - 175,486,830UniSTSRGSC3.4
Celera2163,113,195 - 163,113,389UniSTS
RH 3.4 Map21105.0UniSTS
Cytogenetic Map2q34UniSTS
UniSTS:471844  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22169,095,932 - 169,096,074 (+)MAPPERmRatBN7.2
Rnor_6.02182,730,146 - 182,730,287NCBIRnor6.0
Rnor_5.02202,142,647 - 202,142,788UniSTSRnor5.0
RGSC_v3.42175,485,734 - 175,485,875UniSTSRGSC3.4
Celera2163,112,293 - 163,112,434UniSTS
Cytogenetic Map2q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 82 81 50 25 50 6 209 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000012658   ⟹   ENSRNOP00000012659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2169,089,517 - 169,097,063 (+)Ensembl
Rnor_6.0 Ensembl2182,723,854 - 182,731,764 (+)Ensembl
RefSeq Acc Id: NM_001100700   ⟹   NP_001094170
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82171,387,536 - 171,395,081 (+)NCBI
mRatBN7.22169,089,517 - 169,097,064 (+)NCBI
Rnor_6.02182,723,732 - 182,731,277 (+)NCBI
Rnor_5.02202,136,233 - 202,143,778 (+)NCBI
RGSC_v3.42175,479,320 - 175,486,865 (+)RGD
Celera2163,105,875 - 163,113,424 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001094170 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI61900 (Get FASTA)   NCBI Sequence Viewer  
  CAD90761 (Get FASTA)   NCBI Sequence Viewer  
  EDM00833 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012659.4
RefSeq Acc Id: NP_001094170   ⟸   NM_001100700
- Peptide Label: precursor
- UniProtKB: B1WBV2 (UniProtKB/TrEMBL),   F7EPG0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012659   ⟸   ENSRNOT00000012658
Protein Domains
FZ   NTR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B1WBV2-F1-model_v2 AlphaFold B1WBV2 1-295 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735163 AgrOrtholog
BioCyc Gene G2FUF-52649 BioCyc
Ensembl Genes ENSRNOG00000009465 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012658.7 UniProtKB/TrEMBL
Gene3D-CATH 1.10.2000.10 UniProtKB/TrEMBL
  2.40.50.120 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8367121 IMAGE-MGC_LOAD
InterPro Frizzled/SFRP UniProtKB/TrEMBL
  Frizzled_dom UniProtKB/TrEMBL
  Frizzled_dom_sf UniProtKB/TrEMBL
  Netrin_domain UniProtKB/TrEMBL
  Netrin_module_non-TIMP UniProtKB/TrEMBL
  SFRP2_CRD UniProtKB/TrEMBL
  TIMP-like_OB-fold UniProtKB/TrEMBL
KEGG Report rno:310552 UniProtKB/TrEMBL
MGC_CLONE MGC:187620 IMAGE-MGC_LOAD
NCBI Gene 310552 ENTREZGENE
PANTHER PTHR11309 UniProtKB/TrEMBL
  SECRETED FRIZZLED-RELATED PROTEIN 1 UniProtKB/TrEMBL
Pfam NTR UniProtKB/TrEMBL
  PF01392 UniProtKB/TrEMBL
PhenoGen Sfrp2 PhenoGen
PROSITE NTR UniProtKB/TrEMBL
  PS50038 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009465 RatGTEx
SMART C345C UniProtKB/TrEMBL
  FRI UniProtKB/TrEMBL
Superfamily-SCOP Frizzled_Cys-rich UniProtKB/TrEMBL
  TIMP_like UniProtKB/TrEMBL
UniProt B1WBV2 ENTREZGENE, UniProtKB/TrEMBL
  F7EPG0 ENTREZGENE, UniProtKB/TrEMBL
  Q80W55_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-07-08 Sfrp2  secreted frizzled-related protein 2      Symbol and Name status set to approved 1299863 APPROVED