Cyss (cystatin S) - Rat Genome Database

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Gene: Cyss (cystatin S) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Cyss
Name: cystatin S
RGD ID: 735160
Description: Enables cysteine-type endopeptidase inhibitor activity and protease binding activity. Involved in several processes, including negative regulation of peptidase activity; response to chromate; and response to protozoan. Located in extracellular space and secretory granule. Orthologous to human CST4 (cystatin S) and CST1 (cystatin SN); INTERACTS WITH ammonium chloride; cocaine; doramapimod.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cst4; cystatin-1; cystatin-S; LM protein; protein LM
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Allele / Splice: CyssTn(sb-T2/Bart3)2.173Mcwi  
Genetic Models: F344-CyssTn(sb-T2/Bart3)2.173Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83157,892,660 - 157,897,265 (-)NCBIGRCr8
mRatBN7.23137,432,049 - 137,436,654 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3137,432,049 - 137,436,610 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3141,366,270 - 141,370,587 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03149,949,958 - 149,954,275 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03147,665,268 - 147,669,606 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03144,427,430 - 144,431,768 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3144,427,207 - 144,431,806 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03150,801,395 - 150,805,733 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43138,826,625 - 138,830,963 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13138,732,197 - 138,736,536 (-)NCBI
Celera3136,119,326 - 136,123,644 (-)NCBICelera
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Abnormally high levels of cystatin S in submandibular glands, saliva, and gingiva of plaque-resistant rats. Abe K, etal., J Dent Res. 1998 Nov;77(11):1913-9.
2. Amino acid sequence of an inducible cysteine proteinase inhibitor (cystatin) from submandibular glands of isoproterenol-treated rats. Bedi GS Arch Biochem Biophys 1989 Aug 15;273(1):245-53.
3. The effect of adrenergic agonists and antagonists on cysteine-proteinase inhibitor (cystatin) in rat saliva. Bedi GS Arch Oral Biol. 1991;36(8):611-8.
4. The effect of adrenergic agonists and antagonists on the expression of proteins in rat submandibular and parotid glands. Bedi GS Crit Rev Oral Biol Med. 1993;4(3-4):565-71.
5. The effects of autonomic drugs on the concentration of kallikrein-like proteases and cysteine-proteinase inhibitor (cystatin) in rat whole saliva. Bedi GS J Dent Res. 1991 May;70(5):924-30.
6. Production of rat salivary cystatin S variant polypeptides in Escherichia coli. Bedi GS, etal., Arch Oral Biol. 1998 Mar;43(3):173-82.
7. Effect of sympathectomy on isoproterenol-induced expression of the cysteine proteinase inhibitor gene, cystatin S, in rat submandibular glands. Chaparro O, etal., Arch Oral Biol. 1997 Oct-Nov;42(10-11):743-54.
8. Induction of type 2 cystatin in rat submandibular glands by systemically administered agents. Cohen RE, etal., Arch Oral Biol. 1993 Apr;38(4):319-25.
9. Induction of type 2 salivary cystatin in immunological and chemical kidney injury. Cohen RE, etal., Crit Rev Oral Biol Med. 1993;4(3-4):553-63.
10. The effect of methotrexate on the expression of a cysteine protease inhibitor (type 2 cystatin) in rat sebaceous glands. Cohen RE, etal., J Dermatol. 1996 Dec;23(12):863-70.
11. Structure, organization and regulation of a rat cysteine proteinase inhibitor-encoding gene. Cox JL and Shaw PA, Gene 1992 Jan 15;110(2):175-80.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Impaired induction of cystatin S gene expression by isoproterenol in the submandibular gland of hypophysectomized rats. Iseki S, etal., Arch Oral Biol. 2005 Jul;50(7):653-60. Epub 2005 Jan 12.
14. Changes in submaxillary gland gene expression in F344 rats by multiple dosing of theophylline. Kajikawa S, etal., Exp Anim. 2006 Apr;55(2):143-6.
15. Bactericidal effect of rat cystatin S on an oral bacterium Porphyromonas gingivalis. Naito Y, etal., Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1995 Jan;110(1):71-5.
16. Glossopharyngeal denervation alters responses to nutrients and toxic substances. Ninomiya Y, etal., Physiol Behav. 1994 Dec;56(6):1179-84.
17. Postnatal changes of gene expression for tissue inhibitors of metalloproteinase-1 and -2 and cystatins S and C, in rat submandibular gland demonstrated by quantitative reverse transcription-polymerase chain reaction. Nishiura T and Abe K, Arch Oral Biol. 1999 Jan;44(1):15-26.
18. GOA pipeline RGD automated data pipeline
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Expression of a functional rat salivary cystatin S polypeptide in Escherichia coli. Sharma A, etal., Arch Oral Biol. 1995 Jul;40(7):639-44.
21. Beta-adrenergic induction of a cysteine-proteinase-inhibitor mRNA in rat salivary glands. Shaw PA and Barka T, Biochem J. 1989 Feb 1;257(3):685-9.
22. Sympathetic and parasympathetic regulation of cystatin S gene expression. Shaw PA and Yu WH, Life Sci. 2001 Dec 7;70(3):301-13.
23. Expression and induction by beta-adrenergic agonists of the cystatin S gene in submandibular glands of developing rats. Shaw PA, etal., Biochem J. 1990 Jan 1;265(1):115-20.
24. Cloning and sequencing of cDNA encoding a rat salivary cysteine proteinase inhibitor inducible by beta-adrenergic agonists. Shaw PA, etal., J Biol Chem 1988 Dec 5;263(34):18133-7.
25. Cystatin S in secretory granules fractions isolated from submandibular gland of infected rats by Trypanosoma cruzi. Silva GA, etal., Tissue Cell. 1995 Apr;27(2):167-72.
26. Immunofluorescence localization of cystatins in human lacrimal gland and in the exorbital lacrimal gland of the rat. Takahashi M, etal., Acta Ophthalmol (Copenh). 1992 Oct;70(5):625-31.
27. Growth inhibition of a human oral bacterium Porphyromonas gingivalis by rat cysteine proteinase inhibitor cystatin S. Umemoto T, etal., Lett Appl Microbiol. 1996 Sep;23(3):151-3.
28. Induction of a specific (LM) protein in the submandibular gland of the rat by repeated amputation of the lower incisor teeth. Yagil C and Barka T, Am J Anat. 1986 Dec;177(4):513-8.

Genomics

Variants

.
Variants in Cyss
31 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:17
Count of miRNA genes:17
Interacting mature miRNAs:17
Transcripts:ENSRNOT00000044345
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3121056165145956249Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat

Markers in Region
D1Mgh18  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23137,433,117 - 137,433,250 (+)MAPPERmRatBN7.2
Rnor_6.03144,428,276 - 144,428,408NCBIRnor6.0
Rnor_5.03150,802,241 - 150,802,373UniSTSRnor5.0
RGSC_v3.43138,826,150 - 138,831,740RGDRGSC3.4
RGSC_v3.43138,827,471 - 138,827,603UniSTSRGSC3.4
RGSC_v3.13138,733,043 - 138,733,176RGD
Celera3136,120,172 - 136,120,284UniSTS
RH 3.4 Map31280.5RGD
RH 3.4 Map31280.5UniSTS
Cytogenetic Map3q41UniSTS


Genetic Models
This gene Cyss is modified in the following models/strains:
F344-CyssTn(sb-T2/Bart3)2.173Mcwi    


Expression

RNA-SEQ Expression

ectoderm
endocrine system
endoderm
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
7 7 1 6 6 1 2 1

Sequence


Ensembl Acc Id: ENSRNOT00000044345   ⟹   ENSRNOP00000044719
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3137,432,049 - 137,436,610 (-)Ensembl
Rnor_6.0 Ensembl3144,427,207 - 144,431,806 (-)Ensembl
RefSeq Acc Id: NM_198685   ⟹   NP_941958
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83157,892,660 - 157,897,265 (-)NCBI
mRatBN7.23137,432,049 - 137,436,654 (-)NCBI
Rnor_6.03144,427,430 - 144,431,768 (-)NCBI
Rnor_5.03150,801,395 - 150,805,733 (-)NCBI
RGSC_v3.43138,826,625 - 138,830,963 (-)RGD
Celera3136,119,326 - 136,123,644 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_941958 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41068 (Get FASTA)   NCBI Sequence Viewer  
  AAB59703 (Get FASTA)   NCBI Sequence Viewer  
  EDL95066 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000044719.1
  ENSRNOP00055032442
  ENSRNOP00060001322
  ENSRNOP00065030406
GenBank Protein P19313 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_941958   ⟸   NM_198685
- Peptide Label: precursor
- UniProtKB: P19313 (UniProtKB/Swiss-Prot),   A6K7F3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000044719   ⟸   ENSRNOT00000044345
Protein Domains
Cystatin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P19313-F1-model_v2 AlphaFold P19313 1-141 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735160 AgrOrtholog
BioCyc Gene G2FUF-47467 BioCyc
Ensembl Genes ENSRNOG00000030857 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055023275 UniProtKB/Swiss-Prot
  ENSRNOG00060001450 UniProtKB/Swiss-Prot
  ENSRNOG00065022087 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000044345.3 UniProtKB/Swiss-Prot
  ENSRNOT00055039981 UniProtKB/Swiss-Prot
  ENSRNOT00060002127 UniProtKB/Swiss-Prot
  ENSRNOT00065037617 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.450.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cystatin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cystatin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_inh_cystat_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:296234 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 296234 ENTREZGENE
PANTHER CYSTATIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYSTATIN-C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cystatin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cyss PhenoGen
PROSITE CYSTATIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000030857 RatGTEx
  ENSRNOG00055023275 RatGTEx
  ENSRNOG00060001450 RatGTEx
  ENSRNOG00065022087 RatGTEx
SMART SM00043 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Cystatin/monellin UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6K7F3 ENTREZGENE, UniProtKB/TrEMBL
  CYTS_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-03-13 Cyss    CysS  cystatin S  Symbol updated 1299863 PROVISIONAL
2006-02-09 CysS  cystatin S      Symbol and Name status set to provisional 70820 PROVISIONAL