Stimate (STIM activating enhancer) - Rat Genome Database

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Gene: Stimate (STIM activating enhancer) Rattus norvegicus
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Symbol: Stimate
Name: STIM activating enhancer
RGD ID: 735152
Description: Predicted to enable calcium channel regulator activity. Predicted to be involved in calcium-mediated signaling using intracellular calcium source and positive regulation of calcineurin-NFAT signaling cascade. Predicted to be located in endoplasmic reticulum membrane and endoplasmic reticulum-plasma membrane contact site. Predicted to be active in cortical endoplasmic reticulum and membrane. Orthologous to several human genes including STIMATE (STIM activating enhancer); INTERACTS WITH 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC361110; MGC108529; STIM-activating enhancer encoded by TMEM110; store-operated calcium entry regulator STIMATE; Tmem110; transmembrane protein 110
RGD Orthologs
Human
Dog
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8166,019,788 - 6,077,272 (+)NCBIGRCr8
mRatBN7.2166,013,392 - 6,070,829 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl166,013,369 - 6,071,816 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx166,025,039 - 6,080,542 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0167,170,501 - 7,225,998 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0166,031,279 - 6,087,652 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0166,903,212 - 6,958,786 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl166,903,212 - 6,958,783 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0166,829,242 - 6,885,529 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4166,248,919 - 6,308,034 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1166,248,916 - 6,308,029 (+)NCBI
Celera169,121,057 - 9,177,183 (-)NCBICelera
Cytogenetic Map16p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12477932   PMID:15489334  


Genomics

Comparative Map Data
Stimate
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8166,019,788 - 6,077,272 (+)NCBIGRCr8
mRatBN7.2166,013,392 - 6,070,829 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl166,013,369 - 6,071,816 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx166,025,039 - 6,080,542 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0167,170,501 - 7,225,998 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0166,031,279 - 6,087,652 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0166,903,212 - 6,958,786 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl166,903,212 - 6,958,783 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0166,829,242 - 6,885,529 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4166,248,919 - 6,308,034 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1166,248,916 - 6,308,029 (+)NCBI
Celera169,121,057 - 9,177,183 (-)NCBICelera
Cytogenetic Map16p16NCBI
STIMATE-MUSTN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38352,833,121 - 52,897,548 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl352,833,121 - 52,897,562 (-)EnsemblGRCh38hg38GRCh38
GRCh37352,867,137 - 52,931,564 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map3p21.1NCBI
HuRef352,928,926 - 52,993,335 (-)NCBIHuRef
CHM1_1352,819,330 - 52,883,786 (-)NCBICHM1_1
T2T-CHM13v2.0352,866,132 - 52,930,551 (-)NCBIT2T-CHM13v2.0
LOC608110
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12036,984,436 - 37,032,198 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2036,916,027 - 36,965,387 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02037,258,227 - 37,308,591 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2037,258,060 - 37,337,173 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12036,694,438 - 36,743,840 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02037,056,761 - 37,106,173 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02037,334,324 - 37,383,708 (+)NCBIUU_Cfam_GSD_1.0

Variants

.
Variants in Stimate
643 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:448
Count of miRNA genes:222
Interacting mature miRNAs:269
Transcripts:ENSRNOT00000023314
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1619639137Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)16285170915884239Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
737825Alc13Alcohol consumption QTL 134.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760916039848Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16422773017696785Rat

Markers in Region
D16Got109  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2166,065,146 - 6,065,313 (+)MAPPERmRatBN7.2
Rnor_6.0166,954,971 - 6,955,135NCBIRnor6.0
Rnor_5.0166,881,714 - 6,881,878UniSTSRnor5.0
RGSC_v3.4166,304,219 - 6,304,383UniSTSRGSC3.4
Celera169,124,708 - 9,124,872UniSTS
Cytogenetic Map16p16UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 18 32 22 19 22 72 21 33 11
Low 25 25 19 19 8 11 2 14 8 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000023314   ⟹   ENSRNOP00000023314
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl166,013,392 - 6,068,961 (+)Ensembl
Rnor_6.0 Ensembl166,903,212 - 6,958,783 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000096526   ⟹   ENSRNOP00000078289
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl166,013,369 - 6,071,816 (+)Ensembl
RefSeq Acc Id: NM_198774   ⟹   NP_942069
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8166,019,843 - 6,075,411 (+)NCBI
mRatBN7.2166,013,392 - 6,068,964 (+)NCBI
Rnor_6.0166,903,212 - 6,958,786 (+)NCBI
Rnor_5.0166,829,242 - 6,885,529 (+)NCBI
RGSC_v3.4166,248,919 - 6,308,034 (+)RGD
Celera169,121,057 - 9,177,183 (-)RGD
Sequence:
RefSeq Acc Id: XM_039094618   ⟹   XP_038950546
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8166,019,979 - 6,077,272 (+)NCBI
mRatBN7.2166,013,502 - 6,070,829 (+)NCBI
RefSeq Acc Id: XM_063275490   ⟹   XP_063131560
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8166,062,520 - 6,077,272 (+)NCBI
RefSeq Acc Id: XM_063275491   ⟹   XP_063131561
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8166,060,961 - 6,077,272 (+)NCBI
RefSeq Acc Id: XM_063275492   ⟹   XP_063131562
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8166,019,788 - 6,077,272 (+)NCBI
RefSeq Acc Id: XR_010058297
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8166,058,640 - 6,062,851 (+)NCBI
RefSeq Acc Id: NP_942069   ⟸   NM_198774
- UniProtKB: Q7TSW6 (UniProtKB/Swiss-Prot),   A6KG24 (UniProtKB/TrEMBL),   A0A8I5ZKL5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023314   ⟸   ENSRNOT00000023314
RefSeq Acc Id: XP_038950546   ⟸   XM_039094618
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000078289   ⟸   ENSRNOT00000096526
RefSeq Acc Id: XP_063131562   ⟸   XM_063275492
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063131561   ⟸   XM_063275491
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063131560   ⟸   XM_063275490
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TSW6-F1-model_v2 AlphaFold Q7TSW6 1-288 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699912
Promoter ID:EPDNEW_R10436
Type:initiation region
Name:Tmem110_1
Description:transmembrane protein 110
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0166,903,165 - 6,903,225EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735152 AgrOrtholog
BioCyc Gene G2FUF-12180 BioCyc
Ensembl Genes ENSRNOG00000017051 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055021131 UniProtKB/Swiss-Prot
  ENSRNOG00060013845 UniProtKB/Swiss-Prot
  ENSRNOG00065015199 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023314 ENTREZGENE
  ENSRNOT00000023314.5 UniProtKB/Swiss-Prot
  ENSRNOT00000096526.1 UniProtKB/TrEMBL
  ENSRNOT00055036098 UniProtKB/Swiss-Prot
  ENSRNOT00060023648 UniProtKB/Swiss-Prot
  ENSRNOT00065025174 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7368117 IMAGE-MGC_LOAD
InterPro STIMATE/YPL162C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:361110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108529 IMAGE-MGC_LOAD
NCBI Gene 361110 ENTREZGENE
PANTHER PTHR31735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STORE-OPERATED CALCIUM ENTRY REGULATOR STIMATE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam STIMATE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Stimate PhenoGen
RatGTEx ENSRNOG00000017051 RatGTEx
  ENSRNOG00055021131 RatGTEx
  ENSRNOG00060013845 RatGTEx
  ENSRNOG00065015199 RatGTEx
UniProt A0A8I5ZKL5 ENTREZGENE, UniProtKB/TrEMBL
  A6KG24 ENTREZGENE, UniProtKB/TrEMBL
  Q7TSW6 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-10-12 Stimate  STIM activating enhancer  Tmem110  transmembrane protein 110  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Tmem110  transmembrane protein 110  LOC361110  hypothetical protein  Symbol and Name updated 1299863 APPROVED
2005-09-30 LOC361110        Symbol and Name status set to provisional 70820 PROVISIONAL