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Gene: Wls (Wnt ligand secretion mediator) Rattus norvegicus

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Symbol:

Wls

Name:

Wnt ligand secretion mediator

RGD ID:

735139

Description:

Enables mu-type opioid receptor binding activity. Involved in positive regulation of dendrite morphogenesis. Located in dendrite cytoplasm; dendrite membrane; and nucleus. Human ortholog(s) of this gene implicated in Zaki syndrome. Orthologous to human WLS (Wnt ligand secretion mediator); PARTICIPATES IN Wnt signaling, canonical pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2-methoxyethanol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

CG6210-like; evenness interrupted homolog; EVI; G protein-coupled receptor 177; Gpr177; integral membrane protein GPR177; LOC108350151; LOC362065; uncharacterized LOC108350151; wntless homolog; wntless homolog (Drosophila); wntless Wnt ligand secretion mediator

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	WLS (Wnt ligand secretion mediator)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Wls (wntless WNT ligand secretion mediator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Wls (Wnt ligand secretion mediator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	WLS (Wnt ligand secretion mediator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	WLS (Wnt ligand secretion mediator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Wls (Wnt ligand secretion mediator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	WLS (Wnt ligand secretion mediator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	WLS (Wnt ligand secretion mediator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Wls (Wnt ligand secretion mediator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	CACNA2D3 (calcium voltage-gated channel auxiliary subunit alpha2delta 3)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Wls (wntless WNT ligand secretion mediator)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	WLS (Wnt ligand secretion mediator)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	wls (Wnt ligand secretion mediator)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	mig-14	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	wls	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	wls	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	251,590,653 - 251,705,991 (+)	NCBI		GRCr8
mRatBN7.2	2	248,931,885 - 249,047,248 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	248,931,903 - 249,048,298 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	256,651,639 - 256,774,797 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	254,545,165 - 254,668,321 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	249,504,626 - 249,627,778 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	266,315,036 - 266,431,220 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	266,315,036 - 266,432,558 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	284,950,842 - 285,064,166 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	258,014,437 - 258,128,180 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	258,029,043 - 258,141,986 (+)	NCBI
Celera	2	240,667,931 - 240,781,679 (+)	NCBI		Celera
Cytogenetic Map	2	q45	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Liver Cirrhosis (ISO)

intellectual disability (ISO)

Zaki syndrome (ISO,ISS)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-methoxyethanol (EXP)

3,3',5,5'-tetrabromobisphenol A (ISO)

3,3',5-triiodo-L-thyronine (ISO)

4,4'-diaminodiphenylmethane (EXP)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (EXP)

acrolein (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

aristolochic acid A (ISO)

Aroclor 1254 (ISO)

arsane (ISO)

arsenic atom (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbamazepine (ISO)

choline (ISO)

cisplatin (EXP,ISO)

clofibrate (ISO)

cobalt dichloride (ISO)

copper atom (EXP)

copper(0) (EXP)

Cuprizon (EXP)

DDE (ISO)

decabromodiphenyl ether (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (ISO)

dorsomorphin (ISO)

endosulfan (EXP)

entinostat (ISO)

folic acid (ISO)

furan (EXP)

genistein (ISO)

L-methionine (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methylmercury chloride (ISO)

N-methyl-4-phenylpyridinium (ISO)

N-nitrosodiethylamine (EXP)

N-nitrosodimethylamine (EXP)

oxaliplatin (EXP)

ozone (ISO)

panobinostat (ISO)

paracetamol (ISO)

permethrin (ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

progesterone (ISO)

propanal (ISO)

rotenone (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

Soman (EXP)

Tetrachlorobisphenol A (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

topotecan (EXP)

trimellitic anhydride (ISO)

triphenyl phosphate (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vitamin E (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

anterior/posterior axis specification (IEA,ISO,ISS)

cementum mineralization (IEA,ISO)

exocrine pancreas development (IEA,ISO)

hindbrain development (IEA,ISO)

intracellular protein transport (IBA,ISO)

mesoderm formation (IEA,ISO)

midbrain development (IEA,ISO)

positive regulation of canonical Wnt signaling pathway (IEA,ISO)

positive regulation of dendrite morphogenesis (IMP)

positive regulation of Wnt protein secretion (ISO,ISS)

positive regulation of Wnt signaling pathway (ISO,ISS)

Wnt protein secretion (IBA,IEA,ISO)

Wnt signaling pathway (IEA,ISO,ISS)

Cellular Component

cytoplasm (IDA)

cytoplasmic vesicle (IEA,ISO,ISS)

cytoplasmic vesicle membrane (IEA)

cytosol (ISO)

dendrite cytoplasm (IDA)

dendrite membrane (IDA)

early endosome (ISO)

early endosome membrane (IEA)

endomembrane system (IBA)

endoplasmic reticulum (IEA,ISO)

endoplasmic reticulum membrane (IEA,ISO)

endosome (IEA)

Golgi apparatus (IEA,ISO,ISS)

Golgi membrane (IEA,ISO)

membrane (IEA)

nucleus (IDA)

organelle membrane (IBA)

plasma membrane (IDA,IEA,ISO)

trans-Golgi network (ISO)

Molecular Function

identical protein binding (ISO)

mu-type opioid receptor binding (IPI)

protein binding (IPI,ISO)

Wnt-protein binding (IBA,IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Wnt signaling, canonical pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Secretion of Wnt ligands requires Evi, a conserved transmembrane protein.	Bartscherer K, etal., Cell. 2006 May 5;125(3):523-33.
2.	A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4.	Bian WJ, etal., Dev Neurobiol. 2015 Aug;75(8):805-22. doi: 10.1002/dneu.22250. Epub 2014 Dec 1.
3.	Wntless in Wnt secretion: molecular, cellular and genetic aspects.	Das S, etal., Front Biol (Beijing). 2012 Dec 1;7(6):587-593.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Morphine-induced trafficking of a mu-opioid receptor interacting protein in rat locus coeruleus neurons.	Jaremko KM, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2014 Apr 3;50:53-65. doi: 10.1016/j.pnpbp.2013.12.003. Epub 2013 Dec 12.
6.	Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence.	Jin J, etal., BMC Neurosci. 2010 Mar 9;11:33. doi: 10.1186/1471-2202-11-33.
7.	Opiate agonist-induced re-distribution of Wntless, a mu-opioid receptor interacting protein, in rat striatal neurons.	Reyes BA, etal., Exp Neurol. 2012 Jan;233(1):205-13. doi: 10.1016/j.expneurol.2011.09.037. Epub 2011 Oct 6.
8.	GOA pipeline	RGD automated data pipeline
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	Comprehensive gene review and curation	RGD comprehensive gene curation
12.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:15326124	PMID:15489334	PMID:16678095	PMID:17804805	PMID:18160348	PMID:19841259	PMID:20614471	PMID:20652957	PMID:24768165	PMID:26501177

Genomics

Comparative Map Data

Wls
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	251,590,653 - 251,705,991 (+)	NCBI		GRCr8
mRatBN7.2	2	248,931,885 - 249,047,248 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	248,931,903 - 249,048,298 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	256,651,639 - 256,774,797 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	254,545,165 - 254,668,321 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	249,504,626 - 249,627,778 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	266,315,036 - 266,431,220 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	266,315,036 - 266,432,558 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	284,950,842 - 285,064,166 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	258,014,437 - 258,128,180 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	258,029,043 - 258,141,986 (+)	NCBI
Celera	2	240,667,931 - 240,781,679 (+)	NCBI		Celera
Cytogenetic Map	2	q45	NCBI

WLS
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	68,098,459 - 68,232,546 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	68,098,473 - 68,233,120 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	68,564,142 - 68,698,229 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	68,336,739 - 68,470,841 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	1	66,854,843 - 66,988,904 (-)	NCBI		Celera
Cytogenetic Map	1	p31.3	NCBI
HuRef	1	66,674,244 - 66,808,306 (-)	NCBI		HuRef
CHM1_1	1	68,679,493 - 68,813,680 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	67,975,934 - 68,110,470 (-)	NCBI		T2T-CHM13v2.0

Wls
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	159,545,287 - 159,644,302 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	159,545,309 - 159,644,300 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	159,839,650 - 159,938,666 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	159,839,672 - 159,938,664 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	159,502,659 - 159,598,042 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	159,775,030 - 159,871,126 (+)	NCBI		MGSCv36	mm8
Celera	3	166,277,256 - 166,372,735 (+)	NCBI		Celera
Cytogenetic Map	3	H4	NCBI
cM Map	3	82.65	NCBI

Wls
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955423	23,374,401 - 23,466,475 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955423	23,374,401 - 23,465,308 (+)	NCBI	ChiLan1.0	ChiLan1.0

WLS
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	158,639,149 - 158,773,214 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	157,798,726 - 157,958,728 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	67,336,009 - 67,470,265 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	69,291,878 - 69,425,652 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	69,318,742 - 69,425,652 (-)	Ensembl	panpan1.1		panPan2

WLS
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	77,053,242 - 77,146,549 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	77,053,237 - 77,317,761 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	79,664,500 - 79,757,209 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	77,650,853 - 77,743,886 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	77,650,543 - 77,764,760 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	77,209,157 - 77,301,736 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	77,102,941 - 77,195,585 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	77,592,036 - 77,684,885 (+)	NCBI		UU_Cfam_GSD_1.0

Wls
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	80,849,811 - 80,951,545 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936591	3,537,981 - 3,639,774 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936591	3,537,981 - 3,639,774 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

WLS
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	144,399,926 - 144,555,880 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	144,242,639 - 144,529,659 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	133,711,371 - 133,819,072 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

WLS
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	64,879,594 - 64,987,460 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	64,879,864 - 64,977,038 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	52,598,873 - 52,734,627 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Wls
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624742	27,481,427 - 27,570,439 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624742	27,481,480 - 27,570,439 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	301
Count of miRNA genes:	183
Interacting mature miRNAs:	209
Transcripts:	ENSRNOT00000055245
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
7207484	Bss108	Bone structure and strength QTL 108	5.3		femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	2	214404877	251712708	Rat
2313073	Bmd75	Bone mineral density QTL 75	4.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	2	218051934	251712708	Rat
2307174	Activ3	Activity QTL 3	4.83	0.000058	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	2	210956252	251712708	Rat
1331794	Bp202	Blood pressure QTL 202	3.66819		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	143344967	251712708	Rat
7207482	Bss107	Bone structure and strength QTL 107	7		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	2	214404877	251712708	Rat
1298075	Scl17	Serum cholesterol level QTL 17	3.4		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	214404877	251712708	Rat
1331805	Cm29	Cardiac mass QTL 29	3.50746		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	2	143344967	251712708	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	151869660	251712708	Rat
1549836	Bss2	Bone structure and strength QTL 2	7.5		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	2	214404877	251712708	Rat
7207490	Bss111	Bone structure and strength QTL 111	6.4		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	2	214404877	251712708	Rat

Markers in Region

RH140979

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	249,043,273 - 249,043,463 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	266,427,246 - 266,427,435	NCBI	Rnor6.0
Rnor_5.0	2	285,060,192 - 285,060,381	UniSTS	Rnor5.0
RGSC_v3.4	2	258,128,322 - 258,128,511	UniSTS	RGSC3.4
Celera	2	240,777,705 - 240,777,894	UniSTS
Cytogenetic Map	2	q45	UniSTS

RH127338

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	249,042,476 - 249,042,657 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	266,426,449 - 266,426,629	NCBI	Rnor6.0
Rnor_5.0	2	285,059,395 - 285,059,575	UniSTS	Rnor5.0
RGSC_v3.4	2	258,127,525 - 258,127,705	UniSTS	RGSC3.4
Celera	2	240,776,908 - 240,777,088	UniSTS
RH 3.4 Map	2	1660.89	UniSTS
Cytogenetic Map	2	q45	UniSTS

RH131641

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	249,043,716 - 249,043,897 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	266,427,689 - 266,427,869	NCBI	Rnor6.0
Rnor_5.0	2	285,060,635 - 285,060,815	UniSTS	Rnor5.0
RGSC_v3.4	2	258,128,765 - 258,128,944	UniSTS	RGSC3.4
Celera	2	240,778,148 - 240,778,328	UniSTS
Cytogenetic Map	2	q45	UniSTS

RH131683

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	249,047,008 - 249,047,189 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	266,430,981 - 266,431,161	NCBI	Rnor6.0
Rnor_5.0	2	285,063,927 - 285,064,107	UniSTS	Rnor5.0
Celera	2	240,781,440 - 240,781,620	UniSTS
RH 3.4 Map	2	1654.31	UniSTS
Cytogenetic Map	2	q45	UniSTS

RH135449

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	249,042,999 - 249,043,218 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	266,426,972 - 266,427,190	NCBI	Rnor6.0
Rnor_5.0	2	285,059,918 - 285,060,136	UniSTS	Rnor5.0
RGSC_v3.4	2	258,128,048 - 258,128,266	UniSTS	RGSC3.4
Celera	2	240,777,431 - 240,777,649	UniSTS
Cytogenetic Map	2	q45	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001085353	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_199408	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039102736	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039102737	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY569010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC062391	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	MW396102	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000055245 ⟹ ENSRNOP00000052120

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	248,931,903 - 249,048,298 (+)	Ensembl
Rnor_6.0 Ensembl	2	266,315,036 - 266,431,216 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000080305 ⟹ ENSRNOP00000073668

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	248,965,421 - 249,048,298 (+)	Ensembl
Rnor_6.0 Ensembl	2	266,317,745 - 266,432,558 (+)	Ensembl

RefSeq Acc Id:

NM_001085353 ⟹ NP_001078822

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	251,590,659 - 251,701,875 (+)	NCBI
mRatBN7.2	2	248,931,916 - 249,043,132 (+)	NCBI
Rnor_6.0	2	266,315,042 - 266,427,104 (+)	NCBI
Rnor_5.0	2	284,950,842 - 285,064,166 (+)	NCBI
RGSC_v3.4	2	258,014,437 - 258,128,180 (+)	RGD
Celera	2	240,667,937 - 240,777,563 (+)	NCBI

Sequence:

show sequence

GGGAACCCAAGCGGCTTCGCCCAGGCATTCGCGCGGGCGCCCGCGGTCTGGGTCCCACCTCCTC
TGCTTTCGCACCCTTGAAGTTTTGGAGCACCAGGAAAAGAGGGCAAGGAAGGAGAGGGGAAGCG
AAAGCATATCCTAAAACATTTACTTAAAGGAGGAAAGAAAAGGGGTCGCAGAAATGGCTGGGGC
AATTATAGAAAACATGAGCACCAAGAAGCTCTGCATTGTTGGAGGGATTCTTCTGGTTTTCCAA
ATCGTTGCCTTTCTGGTGGGAGGCTTGATCGCTCCAGCACCCACAACGGCAGTGTCCTACGTGG
CAGCAAAATGTGTGGATGTCCGGAAGAACCACCATAAAACAAGATGGCTGATGCCCTGGGGACC
AAACAAGTGTAACAAGATCAATGACTTCGAAGAAGCAATTCCAAGGGAAATTGAAGCGAATGAC
ATTGTGTTTTCTGTACACATTCCCCTCCCTTCTATGGAGATGAGCCCATGGTTCCAGTTTATGC
TGTTTATCCTGCAGATAGACATTGCTTTCAAGCTAAACAACCAAATCAGAGAAAATGCAGAAGT
TTCCATGGATGTTTCCCTGGGTTACCGTGATGATATGTTTTCTGAGTGGACTGAAATGGCGCAC
GAAAGAGTACCACGTAAACTCAGATGCACTTTCACATCCCCCAAGACCCCAGAGCATGAAGGTC
GTCATTATGAATGTGATGTCCTTCCTTTCATGGAAATTGGGTCAGTGGCTCATAAGTATTACCT
TCTAAATATCCGGCTACCTGTAAATGAGAAGAAGAAAATCAATGTTGGAATTGGGGAAATAAAG
GACATTCGGTTGGTGGGAATCCACCAAAATGGAGGTTTCACTAAGGTATGGTTTGCTATGAAGA
CCTTCCTCACACCCAGCATCTTCATCATTATGGTGTGGTATTGGAGAAGGATCACCATGATGTC
CCGACCTCCAGTGCTTCTGGAAAAAGTCATCTTTGCCCTTGGGATTTCCATGACCTTTATCAAT
ATCCCTGTGGAATGGTTTTCCATTGGATTTGATTGGACCTGGATGCTGTTATTTGGTGACATAC
GACAGGGCATCTTCTATGCAATGCTTCTTTCCTTCTGGATCATCTTCTGTGGCGAGCACATGAT
GGATCAACATGAGCGGAATCACATTGCAGGGTATTGGAAGCAAGTTGGACCAATTGCTGTTGGC
TCTTTCTGCCTCTTCATATTTGACATGTGTGAGAGAGGAGTGCAACTCACAAATCCTTTCTACA
GTATCTGGACTACAGATGTTGGAACAGAACTGGCTATGGCTTTCATCATTGTGGCAGGTATCTG
CCTCTGCCTCTACTTCCTGTTTCTGTGTTTCATGGTATTTCAAGTATTCAGAAACATCAGTGGG
AAACAGTCTAGCCTCCCAGCCATGAGCAAAGTCCGGAGGCTGCACTATGAGGGTCTGATTTTCA
GGTTCAAGTTCCTCATGCTGATCACCTTGGCTTGTGCTGCCATGACTGTTATCTTCTTCATTGT
TAGTCAGGTGACAGAAGGCCATTGGAAATGGGGTGGGGTCACAGTTCAAGTGAGCAGTGCTTTC
TTCACTGGAATCTATGGGATGTGGAACCTGTATGTCTTTGCTTTGATGTTCTTGTATGCACCAT
CCCATAAGAACTATGGGGAAGACCAGTCTAATGGTGACCTGGGTGTCCACAGCGGGGAAGAACT
GCAGCTCACTACCACAATCACCCATGTAGATGGACCGACTGAGATCTACAAGTTGACCCGTAAA
GAAGCACAGGAGTAGTAGGCTATGGTATGGCACTGGGCTGGAATTGTCTCTCTGTCCAGCCTCT
TCCCCTGGAAAAGATGTCCTACTATACAGAGAGCAGTGAAAAGTGAATGCCTAATGCTTCTTAG
GTATAGTTTCTTAGAACAATGGATGGACATTTGTCAGATGACCTCCAATGGTGGCTGTTGTAAG
ACTTCTGCCTATGTAGCATATGATAACAAAAACTGATATGACACATTTTTTCTGTGATCATTGT
TAATTAGTGACATAGCAACATCTGTAGCAGCTGGGTTAATAACCCTTACATAGAGGGATATATA
GGATGGTTTGGGCCAATAGGCATTATATTGAGTAGATTATGGTTATTTTTTTCTGTTTTAGATT
CTGGGATATGTTTAAACATTCTTTGCAGGCCAAACATTTGCTGATGTCATAGCATTTTCACTCT
CCTCCATGGGCACTTTTTTTCTATTTATATCACCAAGTAGCCAACAGAGTTATTCAAGTTGTCA
GTACAAATATATCCACTTTTTAAAAAATGGATTACTATAAAATAACCAAACTTCATGAGAAATT
CTATCTTACCAGAGGCATTTCAGCTTTTAAACCAAATCTGTGTATTTGATACTAATCTGTCTGT
TGGATGTGGATTTTGAGAAATATTTGCTAAATTACCCAAATAGGATTTCTTTTATTAAATGGCC
TTTGGGTCCTAAAAAGCTTTTTAAACTTCTTGCTTGAAATGTGTTTTCTTTTGATAAGATGTTT
CAAACAGCCTCCAAAACTGTAAATCCAATCATTTGAATAAAATGAATGTAAACATGCAAAAAAA
AAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

NM_199408 ⟹ NP_955440

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	251,590,653 - 251,705,991 (+)	NCBI
mRatBN7.2	2	248,931,910 - 249,047,248 (+)	NCBI
Rnor_6.0	2	266,315,036 - 266,431,220 (+)	NCBI
Rnor_5.0	2	284,950,842 - 285,064,166 (+)	NCBI
RGSC_v3.4	2	258,014,437 - 258,128,180 (+)	RGD
Celera	2	240,667,931 - 240,781,679 (+)	RGD

Sequence:

show sequence

CATCTGGGGAACCCAAGCGGCTTCGCCCAGGCATTCGCGCGGGCGCCCGCGGTCTGGGTCCCAC
CTCCTCTGCTTTCGCACCCTTGAAGTTTTGGAGCACCAGGAAAAGAGGGCAAGGAAGGAGAGGG
GAAGCGAAAGCATATCCTAAAACATTTACTTAAAGGAGGAAAGAAAAGGGGTCGCAGAAATGGC
TGGGGCAATTATAGAAAACATGAGCACCAAGAAGCTCTGCATTGTTGGAGGGATTCTTCTGGTT
TTCCAAATCGTTGCCTTTCTGGTGGGAGGCTTGATCGCTCCAGCACCCACAACGGCAGTGTCCT
ACGTGGCAGCAAAATGTGTGGATGTCCGGAAGAACCACCATAAAACAAGATGGCTGATGCCCTG
GGGACCAAACAAGTGTAACAAGATCAATGACTTCGAAGAAGCAATTCCAAGGGAAATTGAAGCG
AATGACATTGTGTTTTCTGTACACATTCCCCTCCCTTCTATGGAGATGAGCCCATGGTTCCAGT
TTATGCTGTTTATCCTGCAGATAGACATTGCTTTCAAGCTAAACAACCAAATCAGAGAAAATGC
AGAAGTTTCCATGGATGTTTCCCTGGGTTACCGTGATGATATGTTTTCTGAGTGGACTGAAATG
GCGCACGAAAGAGTACCACGTAAACTCAGATGCACTTTCACATCCCCCAAGACCCCAGAGCATG
AAGGTCGTCATTATGAATGTGATGTCCTTCCTTTCATGGAAATTGGGTCAGTGGCTCATAAGTA
TTACCTTCTAAATATCCGGCTACCTGTAAATGAGAAGAAGAAAATCAATGTTGGAATTGGGGAA
ATAAAGGACATTCGGTTGGTGGGAATCCACCAAAATGGAGGTTTCACTAAGGTATGGTTTGCTA
TGAAGACCTTCCTCACACCCAGCATCTTCATCATTATGGTGTGGTATTGGAGAAGGATCACCAT
GATGTCCCGACCTCCAGTGCTTCTGGAAAAAGTCATCTTTGCCCTTGGGATTTCCATGACCTTT
ATCAATATCCCTGTGGAATGGTTTTCCATTGGATTTGATTGGACCTGGATGCTGTTATTTGGTG
ACATACGACAGGGCATCTTCTATGCAATGCTTCTTTCCTTCTGGATCATCTTCTGTGGCGAGCA
CATGATGGATCAACATGAGCGGAATCACATTGCAGGGTATTGGAAGCAAGTTGGACCAATTGCT
GTTGGCTCTTTCTGCCTCTTCATATTTGACATGTGTGAGAGAGGAGTGCAACTCACAAATCCTT
TCTACAGTATCTGGACTACAGATGTTGGAACAGAACTGGCTATGGCTTTCATCATTGTGGCAGG
TATCTGCCTCTGCCTCTACTTCCTGTTTCTGTGTTTCATGGTATTTCAAGTATTCAGAAACATC
AGTGGGAAACAGTCTAGCCTCCCAGCCATGAGCAAAGTCCGGAGGCTGCACTATGAGGGTCTGA
TTTTCAGGTTCAAGTTCCTCATGCTGATCACCTTGGCTTGTGCTGCCATGACTGTTATCTTCTT
CATTGTTAGTCAGGTGACAGAAGGCCATTGGAAATGGGGTGGGGTCACAGTTCAAGTGAGCAGT
GCTTTCTTCACTGGAATCTATGGGATGTGGAACCTGTATGTCTTTGCTTTGATGTTCTTGTATG
CACCATCCCATAAGAACTATGGGGAAGACCAGTCTAATGGTGACCTGGGTGTCCACAGCGGGGA
AGAACTGCAGCTCACTACCACAATCACCCATGTAGATGGACCGACTGAGATCTACAAGTTGACC
CGTAAAGAAGCACAGGAGTAGTAGGCTATGGCATTCATCCTCAGGGCAGGTGATGAAGCCAAGT
TGCTGGTGCATGCTGACCCTCATGAATATGCTTTCGTATCTTTATGTCCCAGGATCATTTTTAT
CCTGTCACGTTTACAAGAACATTTCTGACATGCATACGTTTACTTTTACCATGTATTAGTTACT
TTTATATTTCTGTGATAAAACACCATGAGAAATACAATTTACAGAAGGAAAGTATTATTTGGGT
TTATTTTTTATGGTCGGGAGGTGGGGAAGCATGTAAGCAGCATGAGGCCTGATGGCAGGAACAG
AAAAGTTAGGGCTTACATCTCAGCCGCAAGCACAAAGAAGAGAGAGAGAAAACTGGAAGTAGGG
TGAGTCTTAAACTCTCAAAACTGGGCTTCAGCAAAATACTAACTCAGCCCAACTTCACCCCATA
ATGTTCCTTCCCCAAGCAGCTATGTCAGCCGTATTCAGATACATTTCTTGTGTAAACCACTGCA
TTGTCTCCTCTGATAGATAGAATTTCCTGGTTTGTAACTACATCAGTAGCCCCTTTTCCGCTGA
TATCAGAGGGGTCTTCCAGGGATGTTTAAACTCAGGTGTAAAGAGTTTTCTCTTTTCTCACCGA
TGCACATACTCTTAGAGTTAGAAATGTCCATTAGTGTTTGTATCAGGCCTTTCCTTTCTAACTT
TCCTTTTTCGTGCTGACTGTCCCTTGCCATAGCTCCATGTGCACCCCTTCACAGTTTCCACACA
GTTTCCCCATTATTGCTGATTATCCTGTTTGGTTTCTCATGAAACCAAAATACTGCACCGAGAA
TACAGTAAGAATAAAACAGTGCTCTGACCGGAACAGGGTAATGTGAAAATGGCCCCTCTTGCAT
GTGCTGGTTAGAATAGGTATAGCTTCCCTAGACTCCTTACCAATAAGAATCATCATTGTTAGGA
GACGTGGCCTGTTCAAACTACTCCCATGGGACTCCCAGCTCCTTCTCCAGCACCATTCCTGCCT
CCATGACAATACGTGATTAAACTTCTGAAGCTCTAAGCTGACCCCAATTAAATGTTTTCCTTTG
TGAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039102736 ⟹ XP_038958664

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	251,590,768 - 251,701,778 (+)	NCBI
mRatBN7.2	2	248,931,900 - 249,043,035 (+)	NCBI

RefSeq Acc Id:

XM_039102737 ⟹ XP_038958665

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	251,590,824 - 251,701,778 (+)	NCBI
mRatBN7.2	2	248,931,885 - 249,043,035 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001078822	(Get FASTA)	NCBI Sequence Viewer
	NP_955440	(Get FASTA)	NCBI Sequence Viewer
	XP_038958664	(Get FASTA)	NCBI Sequence Viewer
	XP_038958665	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH62391	(Get FASTA)	NCBI Sequence Viewer
	AAS75313	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000052120
	ENSRNOP00000052120.2
	ENSRNOP00000073668.2
GenBank Protein	Q6P689	(Get FASTA)	NCBI Sequence Viewer
	QST78132	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_955440 ⟸ NM_199408

- UniProtKB:

Q6P689 (UniProtKB/Swiss-Prot), A0A0G2K645 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAGAIIENMSTKKLCIVGGILLVFQIVAFLVGGLIAPAPTTAVSYVAAKCVDVRKNHHKTRWLM
PWGPNKCNKINDFEEAIPREIEANDIVFSVHIPLPSMEMSPWFQFMLFILQIDIAFKLNNQIRE
NAEVSMDVSLGYRDDMFSEWTEMAHERVPRKLRCTFTSPKTPEHEGRHYECDVLPFMEIGSVAH
KYYLLNIRLPVNEKKKINVGIGEIKDIRLVGIHQNGGFTKVWFAMKTFLTPSIFIIMVWYWRRI
TMMSRPPVLLEKVIFALGISMTFINIPVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFWIIFCG
EHMMDQHERNHIAGYWKQVGPIAVGSFCLFIFDMCERGVQLTNPFYSIWTTDVGTELAMAFIIV
AGICLCLYFLFLCFMVFQVFRNISGKQSSLPAMSKVRRLHYEGLIFRFKFLMLITLACAAMTVI
FFIVSQVTEGHWKWGGVTVQVSSAFFTGIYGMWNLYVFALMFLYAPSHKNYGEDQSNGDLGVHS
GEELQLTTTITHVDGPTEIYKLTRKEAQE

hide sequence

RefSeq Acc Id:

NP_001078822 ⟸ NM_001085353

- UniProtKB:

Q6P689 (UniProtKB/Swiss-Prot), A0A0G2K645 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAGAIIENMSTKKLCIVGGILLVFQIVAFLVGGLIAPAPTTAVSYVAAKCVDVRKNHHKTRWLM
PWGPNKCNKINDFEEAIPREIEANDIVFSVHIPLPSMEMSPWFQFMLFILQIDIAFKLNNQIRE
NAEVSMDVSLGYRDDMFSEWTEMAHERVPRKLRCTFTSPKTPEHEGRHYECDVLPFMEIGSVAH
KYYLLNIRLPVNEKKKINVGIGEIKDIRLVGIHQNGGFTKVWFAMKTFLTPSIFIIMVWYWRRI
TMMSRPPVLLEKVIFALGISMTFINIPVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFWIIFCG
EHMMDQHERNHIAGYWKQVGPIAVGSFCLFIFDMCERGVQLTNPFYSIWTTDVGTELAMAFIIV
AGICLCLYFLFLCFMVFQVFRNISGKQSSLPAMSKVRRLHYEGLIFRFKFLMLITLACAAMTVI
FFIVSQVTEGHWKWGGVTVQVSSAFFTGIYGMWNLYVFALMFLYAPSHKNYGEDQSNGDLGVHS
GEELQLTTTITHVDGPTEIYKLTRKEAQE

hide sequence

Ensembl Acc Id:

ENSRNOP00000073668 ⟸ ENSRNOT00000080305

Ensembl Acc Id:

ENSRNOP00000052120 ⟸ ENSRNOT00000055245

RefSeq Acc Id:	XP_038958665 ⟸ XM_039102737
- Peptide Label:	isoform X1
- UniProtKB:	A6HWU8 (UniProtKB/TrEMBL), A0A0G2K645 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038958664 ⟸ XM_039102736
- Peptide Label:	isoform X2
- UniProtKB:	A0A0G2K645 (UniProtKB/TrEMBL)

Protein Domains

Wntless GOLD Wntless-like transmembrane

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6P689-F1-model_v2	AlphaFold	Q6P689	1-541	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691845

Promoter ID:

EPDNEW_R2369

Type:

initiation region

Name:

Wls_1

Description:

wntless Wnt ligand secretion mediator

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	266,315,019 - 266,315,079	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:735139	AgrOrtholog
BioCyc Gene	G2FUF-50682	BioCyc
Ensembl Genes	ENSRNOG00000036816	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000055245	ENTREZGENE
	ENSRNOT00000055245.4	UniProtKB/Swiss-Prot
	ENSRNOT00000080305.2	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:5621215	IMAGE-MGC_LOAD
InterPro	WLS-like_TM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	WLS_GOLD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Wntless	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:362065	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:72636	IMAGE-MGC_LOAD
NCBI Gene	362065	ENTREZGENE
PANTHER	PROTEIN WNTLESS HOMOLOG	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR13449	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	MIG-14_Wnt-bd	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	WLS_GOLD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Wls	PhenoGen
RatGTEx	ENSRNOG00000036816	RatGTEx
UniProt	A0A0G2K645	ENTREZGENE, UniProtKB/TrEMBL
	A0A8A1UKH9_RAT	UniProtKB/TrEMBL
	A6HWU8	ENTREZGENE, UniProtKB/TrEMBL
	Q6P689	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Wls	Wnt ligand secretion mediator	LOC108350151	uncharacterized LOC108350151	Data merged from RGD:11514906	737654	PROVISIONAL
2018-12-04	Wls	Wnt ligand secretion mediator	Wls	wntless Wnt ligand secretion mediator	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-08-02	LOC108350151	uncharacterized LOC108350151			Symbol and Name status set to provisional	70820	PROVISIONAL
2013-11-11	Wls	wntless Wnt ligand secretion mediator	Wls	wntless homolog (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-08-02	Wls	wntless homolog (Drosophila)	Gpr177	G protein-coupled receptor 177	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-05	Gpr177	G protein-coupled receptor 177	LOC362065	CG6210-like	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-09-30	LOC362065				Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

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