Tlr2 (toll-like receptor 2) - Rat Genome Database

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Gene: Tlr2 (toll-like receptor 2) Rattus norvegicus
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Symbol: Tlr2
Name: toll-like receptor 2
RGD ID: 735138
Description: Enables lipopeptide binding activity. Involved in several processes, including central nervous system myelin formation; positive regulation of interleukin-10 production; and response to molecule of bacterial origin. Located in cell body; cell projection; and cell surface. Used to study carotid stenosis; ileitis; keratitis; lung disease (multiple); and renal fibrosis. Biomarker of kidney failure; lung disease; metabolic dysfunction and alcohol associated liver disease; pancreatitis (multiple); and perinatal necrotizing enterocolitis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dermatitis (multiple); gastrointestinal system cancer (multiple); lung disease (multiple); and rhinitis (multiple). Orthologous to human TLR2 (toll like receptor 2); PARTICIPATES IN Toll-like receptor signaling pathway; Chagas disease pathway; Entamoebiasis pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: toll-like receptor 2 variant 1; toll-like receptor 2 variant 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Iddm54
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82171,499,189 - 171,504,831 (-)NCBIGRCr8
mRatBN7.22169,200,620 - 169,206,819 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2169,197,419 - 169,206,630 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2176,379,970 - 176,385,353 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02174,399,903 - 174,405,286 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02169,001,363 - 169,006,752 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02182,840,171 - 182,846,061 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2182,840,727 - 182,846,061 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02202,252,701 - 202,258,962 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42175,607,990 - 175,613,992 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12175,558,096 - 175,564,098 (-)NCBI
Celera2163,202,040 - 163,207,399 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome 1  (ISO)
acne  (ISO)
acute kidney failure  (ISO)
Acute Lung Injury  (IEP,IMP)
acute necrotizing pancreatitis  (IEP)
Acute Tubulointerstitial Nephritis  (ISO)
alcohol dependence  (ISO)
alcohol use disorder  (IEP,ISO)
alcohol withdrawal syndrome  (ISO)
Alcohol-Related Disorders  (ISO)
alcoholic liver cirrhosis  (ISO)
Alcoholic Liver Diseases  (ISO)
allergic conjunctivitis  (ISO)
allergic rhinitis  (ISO)
alveolar echinococcosis  (ISO)
anogenital venereal wart  (ISO)
anterior uveitis  (ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISO)
aspergillosis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
atrial fibrillation  (ISO)
Bacterial Eye Infections  (ISO)
Bacterial Keratitis  (ISO)
bacterial pneumonia  (IDA,ISO)
Behcet's disease  (ISO)
Binge Drinking  (ISO)
Brain Abscess  (ISO)
Brain Hypoxia-Ischemia  (IEP,ISO)
Brain Injuries  (IEP,ISO)
breast cancer  (ISO)
Burns  (ISO)
Cardiac Fibrosis  (IMP)
cardiomyopathy  (ISO)
Cardiotoxicity  (ISO)
carotid artery thrombosis  (ISO)
carotid stenosis  (IDA)
cholangitis  (ISO)
cholestasis  (ISO)
cholesteatoma  (ISO)
cholesteatoma of middle ear  (ISO)
Choroidal Neovascularization  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Pain  (ISO)
Chronic Periodontitis  (ISO)
clonorchiasis  (ISO)
cocaine abuse  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (ISO)
Corneal Graft Rejection  (IEP)
Cough  (ISO)
COVID-19  (ISO)
cutaneous leishmaniasis  (ISO)
cystic echinococcosis  (ISO)
dermatomyositis  (ISO)
Diabetic Nephropathies  (IEP,ISO)
diffuse scleroderma  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
dry eye syndrome  (ISO)
Dyslipidemias  (IGI)
end stage renal disease  (ISO)
endophthalmitis  (ISO)
Endotoxemia  (IDA,ISO)
Eosinophilia  (ISO)
Escherichia Coli Meningitis  (ISO)
essential hypertension  (ISO)
eumycotic mycetoma  (ISO)
Experimental Arthritis  (IEP,ISO)
Experimental Autoimmune Encephalomyelitis  (IEP)
Experimental Autoimmune Neuritis  (IEP)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (IDA,ISO)
eye disease  (ISO)
familial combined hyperlipidemia  (IEP,ISO)
Fever  (ISO)
Fungal Eye Infections  (IEP)
gastroesophageal reflux disease  (ISO)
glomerulonephritis  (ISO)
Gram-Positive Bacterial Infections  (ISO)
Hearing Loss  (ISO)
hepatitis B  (ISO)
hepatocellular carcinoma  (ISO)
Herpes Simplex Encephalitis  (IEP,ISO)
herpes simplex virus keratitis  (ISO)
Human Influenza  (ISO)
hymenolepiasis  (IEP)
Hyperalgesia  (IDA,ISO)
Hypercholesterolemia  (ISO)
Hypertriglyceridemia  (ISO)
ileitis  (IMP)
Inflammation  (IDA,ISO)
invasive aspergillosis  (ISO)
keratitis  (IMP,ISO)
keratoconjunctivitis  (ISO)
kidney failure  (IEP)
Kidney Reperfusion Injury  (IDA,ISO)
Kuhnt-Junius degeneration  (ISO)
leprosy  (ISO)
leptospirosis  (ISO)
liver cirrhosis  (ISO)
Liver Reperfusion Injury  (IEP,ISO)
lung disease  (IDA,IEP,ISO)
mastoiditis  (ISO)
membranoproliferative glomerulonephritis  (ISO)
meningococcal meningitis  (ISO)
metabolic dysfunction and alcohol associated liver disease  (IEP)
metabolic dysfunction-associated steatohepatitis  (ISO)
metabolic dysfunction-associated steatotic liver disease  (IEP)
Metabolic Syndrome  (IEP)
middle cerebral artery infarction  (IEP,ISO)
mite infestation  (ISO)
molluscum contagiosum  (ISO)
myelodysplastic syndrome  (ISO)
Myocardial Reperfusion Injury  (IEP)
Nasal Polyps  (ISO)
obesity  (ISO)
obstructive jaundice  (ISO)
Optic Nerve Injuries  (IDA)
Oral Lichen Planus  (ISO)
otitis media  (ISO)
Otitis Media with Effusion  (ISO)
Pain  (IDA)
pancreatitis  (IEP)
perinatal necrotizing enterocolitis  (IEP)
peritonitis  (ISO)
Plaque, Atherosclerotic  (ISO)
Pneumococcal Meningitis  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumocystosis  (ISO)
pneumonia  (ISO)
Postoperative Cognitive Dysfunction  (IEP)
pre-malignant neoplasm  (HEP)
prostate cancer  (ISO)
Pseudomonas Aeruginosa Keratitis  (ISO)
psoriasis  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
renal fibrosis  (IMP)
Reperfusion Injury  (IEP,ISO)
respiratory syncytial virus infectious disease  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
Rhinosinusitis  (ISO)
sciatic neuropathy  (ISO)
seborrheic dermatitis  (ISO)
Sepsis  (IEP)
severe acute respiratory syndrome  (ISO)
sinusitis  (ISO)
skin papilloma  (ISO)
Spinal Cord Injuries  (IEP)
Staphylococcal Infections  (ISO)
steatotic liver disease  (ISO)
stomach cancer  (ISO)
Streptococcal Infections  (ISO)
suppurative otitis media  (ISO)
transient cerebral ischemia  (IEP,ISO)
Transplant Rejection  (IEP,ISO)
tuberculosis  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (IEP)
typhoid fever  (ISO)
uric acid nephrolithiasis  (IEP)
urinary bladder cancer  (ISO)
urinary tract infection  (ISO)
Ventilator-Induced Lung Injury  (IEP)
Vibrio Vulnificus Infection  (IEP)
visceral leishmaniasis  (ISO)
vitiligo  (ISO)
Wallerian Degeneration  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2,2-trichloroethanol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-mercaptopropanoic acid  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
adapalene  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
Aflatoxin G1  (ISO)
aldehydo-D-glucose  (ISO)
alfacalcidol  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
alpha-D-galactose  (EXP)
ammonium hexachloroplatinate  (ISO)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
astaxanthin  (ISO)
astemizole  (EXP)
atorvastatin calcium  (ISO)
azathioprine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bortezomib  (ISO)
butanal  (ISO)
butyric acid  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium telluride  (ISO)
cannabidiol  (ISO)
carbon atom  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
cefoxitin  (ISO)
ceftaroline  (ISO)
cerium trichloride  (ISO)
CGP 52608  (ISO)
chitosan  (ISO)
chlorpyrifos  (EXP)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clothianidin  (ISO)
cobalt atom  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
cordycepin  (ISO)
corilagin  (ISO)
cortisol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cyproconazole  (ISO)
D-glucose  (ISO)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (EXP,ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
dopamine  (EXP)
doxorubicin  (EXP,ISO)
elemental carbon  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP)
ethylparaben  (ISO)
fenoldopam  (EXP)
fentanyl  (EXP)
ferric oxide  (ISO)
ferulic acid  (ISO)
fipronil  (EXP)
flavokawain B  (ISO)
folic acid  (ISO)
fonofos  (ISO)
fructose  (ISO)
furan  (EXP)
galactose  (EXP)
genistein  (ISO)
gentamycin  (EXP,ISO)
glucose  (ISO)
glutathione  (ISO)
glycidol  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
graphene oxide  (ISO)
hexamethylene diisocyanate  (ISO)
histamine  (ISO)
homocysteine  (EXP)
hyaluronic acid  (ISO)
hydroxycitronellal  (ISO)
icosanoid  (ISO)
indometacin  (EXP,ISO)
indoprofen  (ISO)
irinotecan  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isoeugenol  (ISO)
ivermectin  (ISO)
kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside  (ISO)
L-ascorbic acid  (ISO)
lead(0)  (ISO)
levamisole  (ISO)
lipophosphoglycan  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (ISO)
lycopene  (ISO)
metformin  (ISO)
methamphetamine  (EXP,ISO)
methotrexate  (EXP,ISO)
methylseleninic acid  (ISO)
metronidazole  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (ISO)
muramyl dipeptide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nitrites  (ISO)
nitroprusside  (ISO)
Nutlin-3  (ISO)
o-anisidine  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (ISO)
pentachlorophenol  (ISO)
pentanal  (ISO)
pentane-2,3-dione  (EXP)
peptidoglycan  (ISO)
phenobarbital  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
poly(I:C)  (ISO)
prednisolone  (ISO)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (ISO)
prostaglandin E2  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 203580  (ISO)
SCH 23390  (EXP)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sodium acetate trihydrate  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (ISO)
sodium propionate  (ISO)
sulfasalazine  (ISO)
sulfur dioxide  (ISO)
sulindac  (EXP)
tacrolimus hydrate  (ISO)
terbufos  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thymoquinone  (EXP)
tibolone  (ISO)
Timosaponin b ii  (ISO)
titanium atom  (EXP)
titanium dioxide  (EXP,ISO)
topotecan  (EXP)
trans-isoeugenol  (ISO)
tributyrin  (EXP)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
Tungsten carbide  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vitamin D  (ISO)
vorinostat  (ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell surface pattern recognition receptor signaling pathway  (ISO)
cellular response to bacterial lipopeptide  (ISO)
cellular response to diacyl bacterial lipopeptide  (ISO)
cellular response to lipoteichoic acid  (ISO)
cellular response to peptidoglycan  (ISO)
cellular response to triacyl bacterial lipopeptide  (ISO)
cellular response to type II interferon  (ISO)
central nervous system myelin formation  (IDA)
defense response  (ISO)
defense response to Gram-positive bacterium  (ISO)
defense response to virus  (IEA)
detection of diacyl bacterial lipopeptide  (ISO)
detection of triacyl bacterial lipopeptide  (ISO)
ERK1 and ERK2 cascade  (ISO)
I-kappaB phosphorylation  (ISO)
immune response  (NAS)
inflammatory response  (IBA)
learning  (ISO)
leukocyte migration  (ISO)
leukotriene metabolic process  (IDA)
microglia development  (ISO)
microglial cell activation  (IDA)
MyD88-dependent toll-like receptor signaling pathway  (ISO)
negative regulation of actin filament polymerization  (ISO)
negative regulation of cell population proliferation  (IDA)
negative regulation of interleukin-12 production  (ISO)
negative regulation of interleukin-17 production  (ISO)
negative regulation of phagocytosis  (ISO)
negative regulation of synapse assembly  (ISO)
neutrophil migration  (ISO)
nitric oxide biosynthetic process  (ISO)
nitric oxide metabolic process  (IDA)
positive regulation of cell migration  (IMP)
positive regulation of cellular response to macrophage colony-stimulating factor stimulus  (ISO)
positive regulation of chemokine production  (ISO)
positive regulation of cytokine production  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of inflammatory response  (IMP,ISO)
positive regulation of interferon-beta production  (ISO)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-10 production  (IDA)
positive regulation of interleukin-12 production  (ISO)
positive regulation of interleukin-18 production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of intracellular signal transduction  (ISO)
positive regulation of leukocyte migration  (ISO)
positive regulation of macrophage cytokine production  (ISO)
positive regulation of MAPK cascade  (IMP)
positive regulation of matrix metallopeptidase secretion  (ISO)
positive regulation of neuron projection development  (IDA)
positive regulation of neutrophil migration  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of non-canonical NF-kappaB signal transduction  (ISO)
positive regulation of oligodendrocyte differentiation  (IDA)
positive regulation of phagocytosis  (IMP)
positive regulation of receptor signaling pathway via JAK-STAT  (IDA)
positive regulation of striated muscle cell apoptotic process  (IMP)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of vascular associated smooth muscle cell migration  (IMP)
positive regulation of Wnt signaling pathway  (ISO)
positive regulation of xenophagy  (ISO)
regulation of dendritic cell cytokine production  (ISO)
response to bacterial lipoprotein  (IDA)
response to bacterium  (ISO)
response to ethanol  (IEP)
response to fatty acid  (IDA)
response to hypoxia  (IEP)
response to insulin  (IEP)
response to lipopolysaccharide  (IEP)
response to molecule of fungal origin  (ISO)
response to peptidoglycan  (ISO)
response to progesterone  (IEP)
response to toxic substance  (IEP)
toll-like receptor 2 signaling pathway  (ISO)
toll-like receptor signaling pathway  (IBA,IDA,IMP,ISO)
toll-like receptor TLR6:TLR2 signaling pathway  (ISO)
xenophagy  (ISO)

References

References - curated
# Reference Title Reference Citation
1. [Changes of Toll-like Receptor mRNA and Related Cytokines in Patients with Hepatic Alveolar Echinococcosis]. Abudusalamu A, etal., Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2016 Dec;34(6):542-6.
2. Serum Toll-Like Receptor-2, Toll-Like Receptor-4 Levels in Patients with HBeAg-Negative Chronic Viral Hepatitis B. Akbal E, etal., Viral Immunol. 2017 May;30(4):278-282. doi: 10.1089/vim.2016.0131. Epub 2017 Apr 17.
3. Complement activation and toll-like receptor-2 signaling contribute to cytokine production after renal ischemia/reperfusion. Amura CR, etal., Mol Immunol. 2012 Oct;52(3-4):249-57. doi: 10.1016/j.molimm.2012.05.020. Epub 2012 Jun 27.
4. Pivotal advance: HMGB1 expression in active lesions of human and experimental multiple sclerosis. Andersson A, etal., J Leukoc Biol. 2008 Nov;84(5):1248-55. Epub 2008 Jul 21.
5. Thymoquinone attenuates rheumatoid arthritis by downregulating TLR2, TLR4, TNF-α, IL-1, and NFκB expression levels. Arjumand S, etal., Biomed Pharmacother. 2019 Mar;111:958-963. doi: 10.1016/j.biopha.2019.01.006. Epub 2019 Jan 9.
6. Blockade of toll-like receptor 2 expression and membrane translocation in rat corneal epithelial cells by glucocorticoid (TobraDex) after penetrating keratoplasty. Bai L, etal., Cornea. 2011 Nov;30(11):1253-9. doi: 10.1097/ICO.0b013e318213f389.
7. Baicalin alleviates collagen‑induced arthritis and suppresses TLR2/MYD88/NF‑κB p65 signaling in rats and HFLS‑RAs. Bai L, etal., Mol Med Rep. 2020 Oct;22(4):2833-2841. doi: 10.3892/mmr.2020.11369. Epub 2020 Jul 28.
8. TLR2 and TLR4 Expression and Inflammatory Cytokines are Altered in the Airway Epithelium of Those with Alcohol Use Disorders. Bailey KL, etal., Alcohol Clin Exp Res. 2015 Sep;39(9):1691-7. doi: 10.1111/acer.12803. Epub 2015 Jul 24.
9. Immunolocalization of toll-like receptor 2 in viral warts and molluscum contagiosum. Bakry OA, etal., Anal Quant Cytol Histol. 2013 Dec;35(6):316-23.
10. Involvement of toll-like receptor 2 in experimental invasive pulmonary aspergillosis. Balloy V, etal., Infect Immun. 2005 Sep;73(9):5420-5.
11. TLR4 links podocytes with the innate immune system to mediate glomerular injury. Banas MC, etal., J Am Soc Nephrol. 2008 Apr;19(4):704-13. doi: 10.1681/ASN.2007040395. Epub 2008 Feb 6.
12. Toll-like-receptor gene polymorphisms in a Tunisian population with Behcet's disease. Ben Dhifallah I, etal., Clin Exp Rheumatol. 2009 Mar-Apr;27(2 Suppl 53):S58-62.
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157. Regulatory actions of Toll-like receptor 2 (TLR2) and TLR4 in Leishmania donovani infection in the liver. Murray HW, etal., Infect Immun. 2013 Jul;81(7):2318-26. doi: 10.1128/IAI.01468-12. Epub 2013 Apr 15.
158. Prevention of the Severity of Post-ischemic Inflammation and Brain Damage by Simultaneous Knockdown of Toll-like Receptors 2 and 4. Nalamolu KR, etal., Neuroscience. 2018 Mar 1;373:82-91. doi: 10.1016/j.neuroscience.2018.01.014. Epub 2018 Jan 12.
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161. Role of Toll-like receptor (TLR) 2 in experimental Bacillus cereus endophthalmitis. Novosad BD, etal., PLoS One. 2011;6(12):e28619. doi: 10.1371/journal.pone.0028619. Epub 2011 Dec 6.
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163. Enhanced expression of Toll-like receptor 2 in lesional tissues and peripheral blood monocytes of patients with oral lichen planus. Ohno S, etal., J Dermatol. 2011 Apr;38(4):335-44.
164. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
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167. Toll-like receptor 2 is essential for the sensing of oxidants during inflammation. Paul-Clark MJ, etal., Am J Respir Crit Care Med. 2009 Feb 15;179(4):299-306. Epub 2008 Nov 14.
168. Combined Tlr2 and Tlr4 deficiency increases radiation-induced pulmonary fibrosis in mice. Paun A, etal., Int J Radiat Oncol Biol Phys. 2010 Jul 15;77(4):1198-205.
169. Puerarin ameliorates experimental alcoholic liver injury by inhibition of endotoxin gut leakage, Kupffer cell activation, and endotoxin receptors expression. Peng JH, etal., J Pharmacol Exp Ther. 2013 Mar;344(3):646-54. doi: 10.1124/jpet.112.201137. Epub 2012 Dec 31.
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172. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
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175. Toll-like receptor expression and activation in mice with experimental dry eye. Redfern RL, etal., Invest Ophthalmol Vis Sci. 2013 Feb 28;54(2):1554-63. doi: 10.1167/iovs.12-10739.
176. GOA pipeline RGD automated data pipeline
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178. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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191. Single-nucleotide Polymorphisms in Genes Encoding Toll-like Receptor -2, -3, -4, and -9 in a Case-Control Study with Bladder Cancer Susceptibility in a North Indian Population. Singh V, etal., Arch Med Res. 2013 Jan;44(1):54-61. doi: 10.1016/j.arcmed.2012.10.008. Epub 2012 Nov 6.
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193. Effect of probiotic treatment on deranged neutrophil function and cytokine responses in patients with compensated alcoholic cirrhosis. Stadlbauer V, etal., J Hepatol. 2008 Jun;48(6):945-51. Epub 2008 Mar 25.
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198. Association of TLR2 gene Arg753Gln polymorphism with urinary tract infection in children. Tabel Y, etal., Int J Immunogenet. 2007 Dec;34(6):399-405.
199. Protective effects of hyperbaric oxygen treatment against spinal cord injury in rats via toll-like receptor 2/nuclear factor-κB signaling. Tan J, etal., Int J Clin Exp Pathol. 2014 Apr 15;7(5):1911-9. eCollection 2014.
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PMID:20023008   PMID:20113783   PMID:20421349   PMID:20441518   PMID:20534434   PMID:20665543   PMID:20717659   PMID:20945380   PMID:21109260   PMID:21343866   PMID:21618349   PMID:21870333  
PMID:21875662   PMID:22033934   PMID:22067617   PMID:22099754   PMID:22198949   PMID:22523073   PMID:23155421   PMID:23447644   PMID:23656243   PMID:23817958   PMID:23826189   PMID:24091496  
PMID:24423688   PMID:24660535   PMID:24846408   PMID:24871424   PMID:25465639   PMID:25534427   PMID:25800037   PMID:25931256   PMID:25990971   PMID:26436391   PMID:26477714   PMID:26649771  
PMID:26898123   PMID:26962463   PMID:27107801   PMID:27108485   PMID:27312383   PMID:27391866   PMID:28078022   PMID:28243080   PMID:28257481   PMID:28293064   PMID:28432060   PMID:28822965  
PMID:28889066   PMID:29536648   PMID:30031930   PMID:30107238   PMID:30222725   PMID:30480410   PMID:31002842   PMID:31678237   PMID:32384574   PMID:32634389   PMID:32879625   PMID:33652137  
PMID:34015428   PMID:35322444   PMID:36972303  


Genomics

Comparative Map Data
Tlr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82171,499,189 - 171,504,831 (-)NCBIGRCr8
mRatBN7.22169,200,620 - 169,206,819 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2169,197,419 - 169,206,630 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2176,379,970 - 176,385,353 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02174,399,903 - 174,405,286 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02169,001,363 - 169,006,752 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02182,840,171 - 182,846,061 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2182,840,727 - 182,846,061 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02202,252,701 - 202,258,962 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42175,607,990 - 175,613,992 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12175,558,096 - 175,564,098 (-)NCBI
Celera2163,202,040 - 163,207,399 (-)NCBICelera
Cytogenetic Map2q34NCBI
TLR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384153,684,280 - 153,710,637 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4153,684,050 - 153,706,260 (+)EnsemblGRCh38hg38GRCh38
GRCh374154,605,432 - 154,627,412 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364154,824,891 - 154,846,693 (+)NCBINCBI36Build 36hg18NCBI36
Build 344154,966,670 - 154,984,135NCBI
Celera4151,929,928 - 151,951,730 (+)NCBICelera
Cytogenetic Map4q31.3NCBI
HuRef4150,336,457 - 150,358,268 (+)NCBIHuRef
CHM1_14154,583,811 - 154,605,614 (+)NCBICHM1_1
T2T-CHM13v2.04157,008,777 - 157,030,716 (+)NCBIT2T-CHM13v2.0
Tlr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39383,743,579 - 83,749,045 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl383,743,579 - 83,749,074 (-)EnsemblGRCm39 Ensembl
GRCm38383,836,272 - 83,841,824 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl383,836,272 - 83,841,767 (-)EnsemblGRCm38mm10GRCm38
MGSCv37383,640,194 - 83,645,530 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36383,922,199 - 83,927,694 (-)NCBIMGSCv36mm8
Celera383,852,064 - 83,857,400 (-)NCBICelera
Cytogenetic Map3E3NCBI
cM Map337.4NCBI
Tlr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554718,014,910 - 8,017,258 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554718,011,710 - 8,019,063 (+)NCBIChiLan1.0ChiLan1.0
TLR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23151,528,318 - 151,594,177 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14151,924,943 - 151,949,250 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04146,024,653 - 146,091,388 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14157,848,058 - 157,870,324 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4157,866,977 - 157,869,331 (+)Ensemblpanpan1.1panPan2
TLR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11551,454,557 - 51,465,429 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1551,454,695 - 51,465,241 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1551,808,717 - 51,811,083 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01552,140,775 - 52,151,566 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11551,404,786 - 51,407,152 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01551,510,608 - 51,512,974 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01551,821,784 - 51,824,151 (+)NCBIUU_Cfam_GSD_1.0
Tlr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530139,016,995 - 39,024,812 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936576527,434 - 529,788 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936576522,234 - 531,660 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl875,411,993 - 75,428,330 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1875,416,257 - 75,428,370 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2879,823,867 - 79,834,881 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TLR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17100,239,533 - 100,565,955 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7100,258,441 - 100,260,795 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603779,891,761 - 79,956,832 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tlr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248584,979,485 - 4,981,833 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248584,931,820 - 4,984,175 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tlr2
49 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:121
Count of miRNA genes:103
Interacting mature miRNAs:108
Transcripts:ENSRNOT00000013025
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2122609194206936711Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168354880185122374Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072175950118Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2152413072175950118Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072175950118Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072175950118Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072175950118Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2152413072175950118Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)228484589169504100Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)228484589169504100Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat

Markers in Region
RH144365  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22169,201,531 - 169,201,724 (+)MAPPERmRatBN7.2
Rnor_6.02182,841,083 - 182,841,275NCBIRnor6.0
Rnor_5.02202,253,613 - 202,253,805UniSTSRnor5.0
RGSC_v3.42175,608,347 - 175,608,539UniSTSRGSC3.4
Celera2163,202,397 - 163,202,589UniSTS
RH 3.4 Map21105.2UniSTS
Cytogenetic Map2q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 59 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_198769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY151255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY151256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF127847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF127848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT730240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000013025   ⟹   ENSRNOP00000013025
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2169,198,149 - 169,206,630 (-)Ensembl
Rnor_6.0 Ensembl2182,840,727 - 182,846,061 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097289   ⟹   ENSRNOP00000095767
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2169,197,419 - 169,206,630 (-)Ensembl
RefSeq Acc Id: NM_198769   ⟹   NP_942064
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82171,499,189 - 171,504,557 (-)NCBI
mRatBN7.22169,201,175 - 169,206,545 (-)NCBI
Rnor_6.02182,840,726 - 182,846,061 (-)NCBI
Rnor_5.02202,252,701 - 202,258,962 (-)NCBI
RGSC_v3.42175,607,990 - 175,613,992 (-)RGD
Celera2163,202,040 - 163,207,399 (-)RGD
Sequence:
RefSeq Acc Id: XM_008761102   ⟹   XP_008759324
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82171,499,189 - 171,504,831 (-)NCBI
mRatBN7.22169,200,620 - 169,206,819 (-)NCBI
Rnor_6.02182,840,171 - 182,846,006 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_942064 (Get FASTA)   NCBI Sequence Viewer  
  XP_008759324 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAN86524 (Get FASTA)   NCBI Sequence Viewer  
  AAN86525 (Get FASTA)   NCBI Sequence Viewer  
  ABL75415 (Get FASTA)   NCBI Sequence Viewer  
  ABL75416 (Get FASTA)   NCBI Sequence Viewer  
  EDM00832 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000013025.3
  ENSRNOP00000095767.1
GenBank Protein QQJ42660 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42661 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42662 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42663 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42664 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42665 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42666 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42667 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42668 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42669 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42670 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42671 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42672 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42673 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42674 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42675 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42676 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42677 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42678 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42679 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42680 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42681 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42682 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42683 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42684 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42685 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42686 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42687 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42688 (Get FASTA)   NCBI Sequence Viewer  
  QQJ42689