Kcnt2 (potassium sodium-activated channel subfamily T member 2) - Rat Genome Database

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Gene: Kcnt2 (potassium sodium-activated channel subfamily T member 2) Rattus norvegicus
Analyze
Symbol: Kcnt2
Name: potassium sodium-activated channel subfamily T member 2
RGD ID: 735074
Description: Enables chloride-activated potassium channel activity. Involved in potassium ion export across plasma membrane. Predicted to be active in plasma membrane. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 57. Orthologous to human KCNT2 (potassium sodium-activated channel subfamily T member 2); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: potassium channel subfamily T member 2; potassium channel, sodium-activated subfamily T, member 2; potassium channel, subfamily T, member 2; sequence like an intermediate conductance potassium channel subunit; Slick; sodium and chloride-activated ATP-sensitive potassium channel Slo2.1; sodium- and chloride-activated ATP-sensitive potassium channel
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21351,664,129 - 52,059,209 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl1357,131,395 - 57,521,836 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01357,130,855 - 57,520,263 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01362,143,990 - 62,534,723 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41353,407,504 - 53,803,012 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11353,421,583 - 53,817,092 (+)NCBI
Celera1351,920,143 - 52,310,493 (+)NCBICelera
Cytogenetic Map13q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
integral component of membrane  (IBA,IEA)
plasma membrane  (IBA,IC,IEA,ISO,ISS)

References

Additional References at PubMed
PMID:15375169   PMID:15717307   PMID:18664322   PMID:19403831   PMID:25347289   PMID:26100633   PMID:26823461  


Genomics

Comparative Map Data
Kcnt2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21351,664,129 - 52,059,209 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl1357,131,395 - 57,521,836 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01357,130,855 - 57,520,263 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01362,143,990 - 62,534,723 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41353,407,504 - 53,803,012 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11353,421,583 - 53,817,092 (+)NCBI
Celera1351,920,143 - 52,310,493 (+)NCBICelera
Cytogenetic Map13q21NCBI
KCNT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1196,225,779 - 196,609,225 (-)EnsemblGRCh38hg38GRCh38
GRCh381196,225,779 - 196,608,560 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371196,194,909 - 196,577,570 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361194,461,536 - 194,844,122 (-)NCBINCBI36hg18NCBI36
Celera1169,303,964 - 169,686,483 (-)NCBI
Cytogenetic Map1q31.3NCBI
HuRef1167,436,578 - 167,819,452 (-)NCBIHuRef
CHM1_11197,616,644 - 197,999,107 (-)NCBICHM1_1
Kcnt2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391140,173,373 - 140,541,783 (+)NCBIGRCm39mm39
GRCm39 Ensembl1140,173,896 - 140,539,805 (+)Ensembl
GRCm381140,245,657 - 140,614,045 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1140,246,158 - 140,612,067 (+)EnsemblGRCm38mm10GRCm38
MGSCv371142,142,834 - 142,506,838 (+)NCBIGRCm37mm9NCBIm37
MGSCv361142,062,668 - 142,426,672 (+)NCBImm8
Celera1142,875,113 - 143,237,483 (+)NCBICelera
Cytogenetic Map1FNCBI
Kcnt2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540633,076,426 - 33,441,793 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540633,080,570 - 33,441,342 (-)NCBIChiLan1.0ChiLan1.0
KCNT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11176,001,997 - 176,391,180 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1176,003,920 - 176,390,592 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01171,722,130 - 172,112,927 (-)NCBIMhudiblu_PPA_v0panPan3
KCNT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1383,006,639 - 3,382,234 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl383,006,140 - 3,380,218 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha383,097,770 - 3,473,355 (+)NCBI
ROS_Cfam_1.0383,003,542 - 3,376,325 (+)NCBI
UMICH_Zoey_3.1382,999,648 - 3,374,824 (+)NCBI
UNSW_CanFamBas_1.0383,391,702 - 3,766,835 (+)NCBI
UU_Cfam_GSD_1.0383,591,639 - 3,964,394 (+)NCBI
Kcnt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934477,990,611 - 78,357,811 (+)NCBI
SpeTri2.0NW_0049366383,789,339 - 4,154,356 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.21023,896,301 - 24,106,816 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12532,790,439 - 33,193,936 (+)NCBI
ChlSab1.1 Ensembl2532,922,277 - 33,192,820 (+)Ensembl
Vero_WHO_p1.0NW_02366605533,705,790 - 34,115,831 (+)NCBI
Kcnt2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247983,579,528 - 3,868,717 (+)NCBI

Position Markers
UniSTS:225072  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21351,851,064 - 51,851,245 (+)MAPPERmRatBN7.2
Rnor_6.01357,316,406 - 57,316,586NCBIRnor6.0
Rnor_5.01362,329,932 - 62,330,112UniSTSRnor5.0
RGSC_v3.41353,594,840 - 53,595,020UniSTSRGSC3.4
Celera1352,105,283 - 52,105,463UniSTS
Cytogenetic Map13q13UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133614753399968921Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)134250834587508345Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)135157782490675199Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134567662990676629Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133734634882346348Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132858445273584452Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)134231074487310744Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)135156924896569248Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131981081464810814Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)132148248158537177Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13901690682995569Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1312193394108478121Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13901690682995569Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1335301263107975663Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133614753364868393Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131107975663Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131107975663Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131107975663Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134357571788575717Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132907693474076934Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131462463159624631Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131462463159624631Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133937292784372927Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)134250834587508345Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132800833873008338Rat
4889861Pur29Proteinuria QTL 2913.80.005total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)134231074486833540Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132907693474076934Rat
6893344Cm79Cardiac mass QTL 791.50.04heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)134905850767207219Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)131409633059096330Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)132005247765052477Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1324502279108770533Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)131409633059096330Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)135108098996080989Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133950130093652524Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:22
Count of miRNA genes:21
Interacting mature miRNAs:22
Transcripts:ENSRNOT00000017884
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 22
Low 12 14 4 4 4 8 8 50 26 31 8 8
Below cutoff 3 31 30 24 13 24 3 2 8 10 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_198762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005492244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC112858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY359443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000017884   ⟹   ENSRNOP00000017884
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1357,131,395 - 57,519,674 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000083693   ⟹   ENSRNOP00000071443
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1357,243,877 - 57,521,836 (+)Ensembl
RefSeq Acc Id: NM_198762   ⟹   NP_942057
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21351,664,612 - 52,057,244 (+)NCBI
Rnor_6.01357,131,395 - 57,519,674 (+)NCBI
Rnor_5.01362,143,990 - 62,534,723 (+)NCBI
RGSC_v3.41353,407,504 - 53,803,012 (+)RGD
Celera1351,920,143 - 52,310,493 (+)RGD
Sequence:
RefSeq Acc Id: XM_006249943   ⟹   XP_006250005
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21351,664,132 - 52,059,209 (+)NCBI
Rnor_6.01357,130,856 - 57,520,263 (+)NCBI
Rnor_5.01362,143,990 - 62,534,723 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017598802   ⟹   XP_017454291
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21351,664,130 - 52,059,209 (+)NCBI
Rnor_6.01357,130,855 - 57,520,263 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017598803   ⟹   XP_017454292
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21351,664,130 - 52,059,209 (+)NCBI
Rnor_6.01357,130,855 - 57,520,263 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017598804   ⟹   XP_017454293
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21351,664,131 - 52,059,209 (+)NCBI
Rnor_6.01357,130,855 - 57,520,263 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017598805   ⟹   XP_017454294
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21351,664,129 - 52,004,838 (+)NCBI
Rnor_6.01357,130,855 - 57,470,614 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039090723   ⟹   XP_038946651
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21351,664,131 - 52,059,209 (+)NCBI
RefSeq Acc Id: XM_039090725   ⟹   XP_038946653
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21351,664,129 - 52,059,209 (+)NCBI
RefSeq Acc Id: XM_039090726   ⟹   XP_038946654
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21351,664,130 - 51,963,784 (+)NCBI
RefSeq Acc Id: XM_039090727   ⟹   XP_038946655
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21351,847,463 - 52,059,209 (+)NCBI
RefSeq Acc Id: XM_039090728   ⟹   XP_038946656
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21351,664,130 - 51,963,779 (+)NCBI
RefSeq Acc Id: XR_005492244
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21351,664,130 - 52,035,300 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_942057   ⟸   NM_198762
- Sequence:
RefSeq Acc Id: XP_006250005   ⟸   XM_006249943
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_017454291   ⟸   XM_017598802
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017454292   ⟸   XM_017598803
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017454293   ⟸   XM_017598804
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017454294   ⟸   XM_017598805
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: ENSRNOP00000071443   ⟸   ENSRNOT00000083693
RefSeq Acc Id: ENSRNOP00000017884   ⟸   ENSRNOT00000017884
RefSeq Acc Id: XP_038946653   ⟸   XM_039090725
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038946654   ⟸   XM_039090726
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038946656   ⟸   XM_039090728
- Peptide Label: isoform X10
RefSeq Acc Id: XP_038946651   ⟸   XM_039090723
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038946655   ⟸   XM_039090727
- Peptide Label: isoform X9
Protein Domains
BK_channel_a   Ion_trans_2   RCK N-terminal

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735074 AgrOrtholog
Ensembl Genes ENSRNOG00000013312 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000017884 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000071443 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017884 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000083693 UniProtKB/TrEMBL
InterPro K_chnl_BK_asu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:304827 UniProtKB/Swiss-Prot
NCBI Gene 304827 ENTREZGENE
Pfam BK_channel_a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcnt2 PhenoGen
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K0H1_RAT UniProtKB/TrEMBL
  KCNT2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnt2  potassium sodium-activated channel subfamily T member 2  Kcnt2  potassium channel, sodium-activated subfamily T, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnt2  potassium channel, sodium-activated subfamily T, member 2  Kcnt2  potassium channel, subfamily T, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Kcnt2  potassium channel, subfamily T, member 2  Slick  sodium- and chloride-activated ATP-sensitive potassium channel  Symbol and Name updated 1299863 APPROVED
2005-07-08 Slick  sodium- and chloride-activated ATP-sensitive potassium channel      Symbol and Name status set to approved 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains C-terminal ATP binding site is required for ATP to reduce the channel's open probability 1299633
gene_expression expressed in the central nervous system and the heart 1299633