Nme8 (NME/NM23 family member 8) - Rat Genome Database

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Gene: Nme8 (NME/NM23 family member 8) Rattus norvegicus
Analyze
Symbol: Nme8
Name: NME/NM23 family member 8
RGD ID: 735069
Description: Predicted to enable 3'-5' exonuclease activity and microtubule binding activity. Predicted to be involved in cilium assembly and flagellated sperm motility. Predicted to act upstream of or within cellular response to reactive oxygen species. Located in sperm fibrous sheath. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 6. Orthologous to human NME8 (NME/NM23 family member 8); INTERACTS WITH bisphenol A; trichloroethene; 17alpha-ethynylestradiol (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3'-5' exonuclease NME8; spermatid-specific thioredoxin-2 protein; sptrx-2; Sptrx2; thioredoxin domain containing 3; thioredoxin domain containing 3 (spermatozoa); thioredoxin domain-containing protein 3; Txndc3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81749,932,861 - 50,000,610 (+)NCBIGRCr8
mRatBN7.21745,237,022 - 45,304,948 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1745,238,120 - 45,304,948 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1747,314,521 - 47,383,402 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01752,073,680 - 52,142,565 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01746,564,073 - 46,632,963 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01747,300,932 - 47,368,543 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1747,301,511 - 47,368,553 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01756,120,328 - 56,185,444 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41753,037,090 - 53,105,985 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11753,040,678 - 53,108,823 (+)NCBI
Celera1751,224,029 - 51,290,939 (-)NCBICelera
Cytogenetic Map17q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
axoneme  (IBA,ISO)
cytoplasm  (ISO)
cytosol  (IEA,ISO)
nuclear speck  (IEA,ISO)
nucleus  (ISO)
outer dynein arm  (IEA,ISO)
sperm cytoplasmic droplet  (IEA,ISO)
sperm fibrous sheath  (IDA)
sperm midpiece  (IEA,ISO)
sperm principal piece  (IBA,IEA,ISO)

Molecular Function
3'-5' exonuclease activity  (IEA,ISO,ISS)
microtubule binding  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Cloning and developmental analysis of murid spermatid-specific thioredoxin-2 (SPTRX-2), a novel sperm fibrous sheath protein and autoantigen. Miranda-Vizuete A, etal., J Biol Chem 2003 Nov 7;278(45):44874-85. Epub 2003 Aug 7.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:17360648   PMID:22871113   PMID:23707457  


Genomics

Comparative Map Data
Nme8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81749,932,861 - 50,000,610 (+)NCBIGRCr8
mRatBN7.21745,237,022 - 45,304,948 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1745,238,120 - 45,304,948 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1747,314,521 - 47,383,402 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01752,073,680 - 52,142,565 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01746,564,073 - 46,632,963 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01747,300,932 - 47,368,543 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1747,301,511 - 47,368,553 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01756,120,328 - 56,185,444 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41753,037,090 - 53,105,985 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11753,040,678 - 53,108,823 (+)NCBI
Celera1751,224,029 - 51,290,939 (-)NCBICelera
Cytogenetic Map17q11NCBI
NME8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38737,848,597 - 37,900,397 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl737,848,597 - 37,900,397 (+)EnsemblGRCh38hg38GRCh38
GRCh37737,888,199 - 37,939,999 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36737,854,724 - 37,906,528 (+)NCBINCBI36Build 36hg18NCBI36
Build 34737,661,438 - 37,713,238NCBI
Celera737,872,948 - 37,924,718 (+)NCBICelera
Cytogenetic Map7p14.1NCBI
HuRef737,768,407 - 37,820,357 (+)NCBIHuRef
CHM1_1737,887,675 - 37,939,959 (+)NCBICHM1_1
T2T-CHM13v2.0737,989,652 - 38,041,414 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2737,926,134 - 37,977,903 (+)NCBI
Nme8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391319,829,248 - 19,881,996 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1319,829,248 - 19,881,964 (-)EnsemblGRCm39 Ensembl
GRCm381319,645,078 - 19,697,826 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1319,645,078 - 19,697,794 (-)EnsemblGRCm38mm10GRCm38
MGSCv371319,736,947 - 19,789,629 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361319,652,543 - 19,705,225 (-)NCBIMGSCv36mm8
Celera1319,988,291 - 19,996,418 (-)NCBICelera
Cytogenetic Map13A2NCBI
cM Map137.0NCBI
Nme8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554605,680,678 - 5,718,628 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554605,672,768 - 5,718,707 (-)NCBIChiLan1.0ChiLan1.0
NME8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2642,326,546 - 42,733,330 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1790,651,590 - 91,058,066 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0738,128,610 - 38,536,611 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1738,708,937 - 38,757,802 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl738,708,937 - 38,757,795 (+)Ensemblpanpan1.1panPan2
NME8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11812,038,369 - 12,088,544 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1812,038,450 - 12,087,626 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1811,682,915 - 11,733,063 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01812,309,712 - 12,359,547 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11812,126,922 - 12,176,754 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01812,047,339 - 12,097,182 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01812,274,833 - 12,324,653 (-)NCBIUU_Cfam_GSD_1.0
Nme8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511893,964,657 - 94,040,183 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647813,177,529 - 13,243,037 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647813,176,388 - 13,243,043 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NME8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9108,358,535 - 108,392,781 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19108,358,289 - 108,393,755 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29119,105,762 - 119,136,177 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NME8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12120,617,683 - 20,670,346 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2120,620,941 - 20,668,888 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660621,671,514 - 1,725,043 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nme8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474023,349,858 - 23,396,888 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474023,351,832 - 23,396,905 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nme8
224 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:166
Count of miRNA genes:62
Interacting mature miRNAs:67
Transcripts:ENSRNOT00000059201, ENSRNOT00000059202, ENSRNOT00000066673
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
7394837Memor18Memory QTL 18exploratory behavior trait (VT:0010471)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)171864018263640182Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172308056759555013Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318457246843Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172702794956836890Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172702794960463643Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172738994653481766Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173136839162109574Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
2313854Bp343Blood pressure QTL 3433.9life span trait (VT:0005372)age at time of death (CMO:0001193)173199078450909196Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)173455084373951021Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173583708569599340Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)173828150983281509Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)173828150983281509Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174054004180387013Rat
1358295Aocep1Aortic cell protein QTL 16.10.00000071thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
631497Bp98Blood pressure QTL 983.66arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)174135465160463643Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)174207316069599340Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)174207316069599340Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7
Low 1 9 17 1 4 1
Below cutoff 1 8 17 12 2 12 8 9 11 4 13 9 8

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_198792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005495310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010058906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC123245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF548544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC097265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000087178   ⟹   ENSRNOP00000074097
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1745,238,126 - 45,304,946 (+)Ensembl
Rnor_6.0 Ensembl1747,301,518 - 47,368,541 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000090021   ⟹   ENSRNOP00000068777
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1745,238,120 - 45,304,948 (+)Ensembl
Rnor_6.0 Ensembl1747,302,272 - 47,364,209 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092051   ⟹   ENSRNOP00000069890
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1745,238,120 - 45,304,948 (+)Ensembl
Rnor_6.0 Ensembl1747,301,511 - 47,368,553 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000095832   ⟹   ENSRNOP00000096759
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1745,238,120 - 45,255,889 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000113182   ⟹   ENSRNOP00000091968
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1745,238,120 - 45,304,808 (+)Ensembl
RefSeq Acc Id: NM_198792   ⟹   NP_942087
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81749,933,753 - 50,000,610 (+)NCBI
mRatBN7.21745,238,087 - 45,304,948 (+)NCBI
Rnor_6.01747,301,512 - 47,368,543 (+)NCBI
Rnor_5.01756,120,328 - 56,185,444 (-)NCBI
RGSC_v3.41753,037,090 - 53,105,985 (+)RGD
Celera1751,224,029 - 51,290,939 (-)RGD
Sequence:
RefSeq Acc Id: XM_017600636   ⟹   XP_017456125
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81749,932,861 - 50,000,610 (+)NCBI
mRatBN7.21745,237,422 - 45,304,948 (+)NCBI
Rnor_6.01747,300,932 - 47,368,543 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600637   ⟹   XP_017456126
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81749,933,756 - 50,000,610 (+)NCBI
mRatBN7.21745,238,090 - 45,304,948 (+)NCBI
Rnor_6.01747,301,473 - 47,368,543 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039095975   ⟹   XP_038951903
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81749,932,884 - 50,000,610 (+)NCBI
mRatBN7.21745,237,424 - 45,304,948 (+)NCBI
RefSeq Acc Id: XM_039095976   ⟹   XP_038951904
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81749,932,884 - 50,000,610 (+)NCBI
mRatBN7.21745,237,025 - 45,304,948 (+)NCBI
RefSeq Acc Id: XM_039095978   ⟹   XP_038951906
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81749,940,331 - 50,000,610 (+)NCBI
mRatBN7.21745,244,665 - 45,304,948 (+)NCBI
RefSeq Acc Id: XM_039095979   ⟹   XP_038951907
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81749,933,756 - 49,969,645 (+)NCBI
mRatBN7.21745,238,090 - 45,273,980 (+)NCBI
RefSeq Acc Id: XM_063276669   ⟹   XP_063132739
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81749,932,884 - 50,000,610 (+)NCBI
RefSeq Acc Id: XM_063276670   ⟹   XP_063132740
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81749,932,884 - 50,000,610 (+)NCBI
RefSeq Acc Id: XM_063276671   ⟹   XP_063132741
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81749,934,902 - 50,000,610 (+)NCBI
RefSeq Acc Id: XR_005495310
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81749,933,756 - 50,000,610 (+)NCBI
mRatBN7.21745,238,090 - 45,304,948 (+)NCBI
RefSeq Acc Id: XR_010058906
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81749,933,756 - 50,000,610 (+)NCBI
RefSeq Acc Id: NP_942087   ⟸   NM_198792
- UniProtKB: F7EU06 (UniProtKB/TrEMBL),   A0A8L2R1L1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456125   ⟸   XM_017600636
- Peptide Label: isoform X1
- UniProtKB: F7EU06 (UniProtKB/TrEMBL),   A0A8L2R1L1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456126   ⟸   XM_017600637
- Peptide Label: isoform X2
- UniProtKB: A0A8L2R1L1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069890   ⟸   ENSRNOT00000092051
RefSeq Acc Id: ENSRNOP00000068777   ⟸   ENSRNOT00000090021
RefSeq Acc Id: ENSRNOP00000074097   ⟸   ENSRNOT00000087178
RefSeq Acc Id: XP_038951904   ⟸   XM_039095976
- Peptide Label: isoform X1
- UniProtKB: F7EU06 (UniProtKB/TrEMBL),   A0A8L2R1L1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951903   ⟸   XM_039095975
- Peptide Label: isoform X1
- UniProtKB: F7EU06 (UniProtKB/TrEMBL),   A0A8L2R1L1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951907   ⟸   XM_039095979
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038951906   ⟸   XM_039095978
- Peptide Label: isoform X4
RefSeq Acc Id: ENSRNOP00000091968   ⟸   ENSRNOT00000113182
RefSeq Acc Id: ENSRNOP00000096759   ⟸   ENSRNOT00000095832
RefSeq Acc Id: XP_063132739   ⟸   XM_063276669
- Peptide Label: isoform X2
- UniProtKB: A0A8L2R1L1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132740   ⟸   XM_063276670
- Peptide Label: isoform X2
- UniProtKB: A0A8L2R1L1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132741   ⟸   XM_063276671
- Peptide Label: isoform X3
Protein Domains
Thioredoxin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q715S9-F1-model_v2 AlphaFold Q715S9 1-587 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700501
Promoter ID:EPDNEW_R11023
Type:single initiation site
Name:Nme8_1
Description:NME/NM23 family member 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01747,301,488 - 47,301,548EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735069 AgrOrtholog
BioCyc Gene G2FUF-9148 BioCyc
Ensembl Genes ENSRNOG00000058285 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000087178.2 UniProtKB/TrEMBL
  ENSRNOT00000090021.2 UniProtKB/TrEMBL
  ENSRNOT00000092051 ENTREZGENE
  ENSRNOT00000092051.2 UniProtKB/TrEMBL
  ENSRNOT00000095832.1 UniProtKB/TrEMBL
  ENSRNOT00000113182 ENTREZGENE
  ENSRNOT00000113182.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.141 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro NDK-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NDK-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:364729 UniProtKB/TrEMBL
NCBI Gene 364729 ENTREZGENE
PANTHER NME/NM23 FAMILY MEMBER 8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOREDOXIN DOMAIN-CONTAINING PROTEIN 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam NDK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nme8 PhenoGen
PROSITE NDPK_LIKE UniProtKB/Swiss-Prot
  THIOREDOXIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOREDOXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000058285 RatGTEx
SMART NDK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54919 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AG97_RAT UniProtKB/TrEMBL
  A0A8I6GLR3_RAT UniProtKB/TrEMBL
  A0A8L2R1L1 ENTREZGENE, UniProtKB/TrEMBL
  F7EU06 ENTREZGENE, UniProtKB/TrEMBL
  Q4V8P5_RAT UniProtKB/TrEMBL
  Q715S9 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-17 Nme8  NME/NM23 family member 8  Txndc3  thioredoxin domain containing 3 (spermatozoa)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Txndc3  thioredoxin domain containing 3 (spermatozoa)    thioredoxin domain containing 3  Name updated 1299863 APPROVED