Rundc3a (RUN domain containing 3A) - Rat Genome Database

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Gene: Rundc3a (RUN domain containing 3A) Rattus norvegicus
Analyze
Symbol: Rundc3a
Name: RUN domain containing 3A
RGD ID: 735057
Description: Involved in positive regulation of cGMP-mediated signaling. Predicted to be located in intracellular membrane-bounded organelle. Orthologous to human RUNDC3A (RUN domain containing 3A); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GCRP; guanylate-cyclase regulatory protein; Rap2 interacting protein; Rap2ip; RUN domain-containing protein 3A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81087,852,746 - 87,861,903 (+)NCBIGRCr8
mRatBN7.21087,352,624 - 87,361,767 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1087,352,646 - 87,361,765 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1092,389,625 - 92,398,742 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01091,854,855 - 91,863,980 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01087,248,187 - 87,257,312 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01090,342,033 - 90,351,172 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1090,342,051 - 90,351,170 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01090,130,382 - 90,139,537 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41091,501,018 - 91,510,151 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11091,521,650 - 91,524,519 (+)NCBI
Celera1086,061,809 - 86,070,930 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Molecular cloning of a regulatory protein for membrane-bound guanylate cyclase GC-A. Chen ZJ, etal., Biochem Biophys Res Commun 2000 Nov 11;278(1):106-11.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Rundc3a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81087,852,746 - 87,861,903 (+)NCBIGRCr8
mRatBN7.21087,352,624 - 87,361,767 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1087,352,646 - 87,361,765 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1092,389,625 - 92,398,742 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01091,854,855 - 91,863,980 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01087,248,187 - 87,257,312 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01090,342,033 - 90,351,172 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1090,342,051 - 90,351,170 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01090,130,382 - 90,139,537 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41091,501,018 - 91,510,151 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11091,521,650 - 91,524,519 (+)NCBI
Celera1086,061,809 - 86,070,930 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
RUNDC3A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381744,308,601 - 44,318,670 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1744,308,413 - 44,318,670 (+)EnsemblGRCh38hg38GRCh38
GRCh371742,385,969 - 42,396,038 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361739,741,490 - 39,750,764 (+)NCBINCBI36Build 36hg18NCBI36
Celera1739,094,632 - 39,104,744 (+)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1738,149,503 - 38,159,613 (+)NCBIHuRef
CHM1_11742,621,581 - 42,631,687 (+)NCBICHM1_1
T2T-CHM13v2.01745,161,680 - 45,171,748 (+)NCBIT2T-CHM13v2.0
Rundc3a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911102,284,219 - 102,293,381 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11102,284,229 - 102,293,381 (+)EnsemblGRCm39 Ensembl
GRCm3811102,393,394 - 102,402,555 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11102,393,403 - 102,402,555 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711102,254,749 - 102,263,869 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611102,209,766 - 102,218,643 (+)NCBIMGSCv36mm8
Celera11114,102,796 - 114,111,916 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1166.29NCBI
Rundc3a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545117,346,844 - 17,352,497 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545117,348,822 - 17,352,271 (+)NCBIChiLan1.0ChiLan1.0
RUNDC3A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21920,592,172 - 20,602,207 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11722,556,531 - 22,566,565 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01713,081,422 - 13,091,457 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11713,246,838 - 13,257,275 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1713,247,285 - 13,256,771 (-)Ensemblpanpan1.1panPan2
RUNDC3A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1919,108,330 - 19,117,908 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl919,107,606 - 19,117,884 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha918,497,487 - 18,506,961 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0919,802,120 - 19,811,598 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl919,802,119 - 19,811,694 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1918,655,900 - 18,665,368 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0918,839,055 - 18,848,513 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0918,983,417 - 18,992,888 (-)NCBIUU_Cfam_GSD_1.0
Rundc3a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560218,426,548 - 18,435,768 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936541758,790 - 770,686 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936541758,815 - 768,050 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RUNDC3A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1218,920,370 - 18,930,223 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11218,920,365 - 18,929,766 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21219,265,073 - 19,274,500 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RUNDC3A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11662,075,458 - 62,085,516 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1662,075,313 - 62,086,132 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607732,844,185 - 32,854,876 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rundc3a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624795721,318 - 727,002 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624795721,025 - 727,006 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rundc3a
45 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:46
Count of miRNA genes:40
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000028487
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108400727295933025Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108400727295933025Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108402232193995963Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
2313856Bp342Blood pressure QTL 3424.40.0001life span trait (VT:0005372)age at time of death (CMO:0001193)108730761796121100Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat

Markers in Region
RH133810  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21087,361,440 - 87,361,635 (+)MAPPERmRatBN7.2
Rnor_6.01090,350,846 - 90,351,040NCBIRnor6.0
Rnor_5.01090,139,211 - 90,139,405UniSTSRnor5.0
RGSC_v3.41091,509,825 - 91,510,019UniSTSRGSC3.4
Celera1086,070,604 - 86,070,798UniSTS
RH 3.4 Map10889.7UniSTS
Cytogenetic Map10q32.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 74 10
Low 3 36 43 27 19 27 2 3 35 31 11 2
Below cutoff 7 14 14 14 6 8 6

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_198758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006247335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006247339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006247340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC134158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF288611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC127472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC158572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB797318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DY319760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000028487   ⟹   ENSRNOP00000028487
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1087,352,646 - 87,361,765 (+)Ensembl
Rnor_6.0 Ensembl1090,342,051 - 90,351,170 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000089616   ⟹   ENSRNOP00000069763
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1087,352,646 - 87,360,939 (+)Ensembl
Rnor_6.0 Ensembl1090,348,299 - 90,351,170 (+)Ensembl
RefSeq Acc Id: NM_198758   ⟹   NP_942053
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,852,782 - 87,861,903 (+)NCBI
mRatBN7.21087,352,646 - 87,361,767 (+)NCBI
Rnor_6.01090,342,051 - 90,351,172 (+)NCBI
Rnor_5.01090,130,382 - 90,139,537 (+)NCBI
RGSC_v3.41091,501,018 - 91,510,151 (+)RGD
Celera1086,061,809 - 86,070,930 (+)RGD
Sequence:
RefSeq Acc Id: XM_006247335   ⟹   XP_006247397
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,852,764 - 87,861,903 (+)NCBI
mRatBN7.21087,352,626 - 87,361,767 (+)NCBI
Rnor_6.01090,342,033 - 90,351,172 (+)NCBI
Rnor_5.01090,130,382 - 90,139,537 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006247339   ⟹   XP_006247401
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,852,746 - 87,861,903 (+)NCBI
mRatBN7.21087,352,626 - 87,361,056 (+)NCBI
Rnor_6.01090,342,033 - 90,350,461 (+)NCBI
Rnor_5.01090,130,382 - 90,139,537 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006247340   ⟹   XP_006247402
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,852,764 - 87,861,903 (+)NCBI
mRatBN7.21087,352,626 - 87,361,056 (+)NCBI
Rnor_6.01090,342,033 - 90,350,461 (+)NCBI
Rnor_5.01090,130,382 - 90,139,537 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008768058   ⟹   XP_008766280
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,852,762 - 87,861,903 (+)NCBI
mRatBN7.21087,352,625 - 87,361,767 (+)NCBI
Rnor_6.01090,342,033 - 90,351,172 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597323   ⟹   XP_017452812
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,852,764 - 87,861,903 (+)NCBI
mRatBN7.21087,352,624 - 87,361,767 (+)NCBI
Rnor_6.01090,342,033 - 90,351,172 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597324   ⟹   XP_017452813
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,852,764 - 87,861,903 (+)NCBI
mRatBN7.21087,352,625 - 87,361,056 (+)NCBI
Rnor_6.01090,342,033 - 90,350,461 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597325   ⟹   XP_017452814
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,852,764 - 87,861,903 (+)NCBI
mRatBN7.21087,352,625 - 87,361,056 (+)NCBI
Rnor_6.01090,342,033 - 90,350,461 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039086113   ⟹   XP_038942041
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,852,764 - 87,861,903 (+)NCBI
mRatBN7.21087,352,626 - 87,361,056 (+)NCBI
RefSeq Acc Id: XM_063269158   ⟹   XP_063125228
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,852,814 - 87,861,903 (+)NCBI
RefSeq Acc Id: XM_063269159   ⟹   XP_063125229
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,852,865 - 87,861,903 (+)NCBI
RefSeq Acc Id: XM_063269160   ⟹   XP_063125230
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,852,773 - 87,861,903 (+)NCBI
RefSeq Acc Id: XM_063269161   ⟹   XP_063125231
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,852,764 - 87,861,903 (+)NCBI
RefSeq Acc Id: XM_063269162   ⟹   XP_063125232
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,852,806 - 87,861,903 (+)NCBI
RefSeq Acc Id: NP_942053   ⟸   NM_198758
- UniProtKB: F1LRZ9 (UniProtKB/TrEMBL),   A6HJI9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247397   ⟸   XM_006247335
- Peptide Label: isoform X2
- UniProtKB: A6HJI8 (UniProtKB/TrEMBL),   A6HJI9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247401   ⟸   XM_006247339
- Peptide Label: isoform X11
- UniProtKB: A6HJI9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247402   ⟸   XM_006247340
- Peptide Label: isoform X8
- UniProtKB: A6HJI9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008766280   ⟸   XM_008768058
- Peptide Label: isoform X4
- UniProtKB: A6HJI9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452812   ⟸   XM_017597323
- Peptide Label: isoform X1
- UniProtKB: A1L117 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452813   ⟸   XM_017597324
- Peptide Label: isoform X6
- UniProtKB: A0A0G2JW67 (UniProtKB/TrEMBL),   A6HJI9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452814   ⟸   XM_017597325
- Peptide Label: isoform X10
- UniProtKB: A6HJI9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069763   ⟸   ENSRNOT00000089616
RefSeq Acc Id: ENSRNOP00000028487   ⟸   ENSRNOT00000028487
RefSeq Acc Id: XP_038942041   ⟸   XM_039086113
- Peptide Label: isoform X7
- UniProtKB: A6HJI9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125231   ⟸   XM_063269161
- Peptide Label: isoform X12
- UniProtKB: A6HJI9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125230   ⟸   XM_063269160
- Peptide Label: isoform X9
- UniProtKB: A1L117 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125232   ⟸   XM_063269162
- Peptide Label: isoform X13
- UniProtKB: A6HJI9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125228   ⟸   XM_063269158
- Peptide Label: isoform X3
- UniProtKB: A6HJI9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125229   ⟸   XM_063269159
- Peptide Label: isoform X5
- UniProtKB: A6HJI9 (UniProtKB/TrEMBL)
Protein Domains
RUN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LRZ9-F1-model_v2 AlphaFold F1LRZ9 1-454 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697786
Promoter ID:EPDNEW_R8310
Type:initiation region
Name:Rundc3a_1
Description:RUN domain containing 3A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01090,342,050 - 90,342,110EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735057 AgrOrtholog
BioCyc Gene G2FUF-23109 BioCyc
Ensembl Genes ENSRNOG00000020970 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028487 ENTREZGENE
  ENSRNOT00000028487.4 UniProtKB/TrEMBL
  ENSRNOT00000089616.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.900 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8361889 IMAGE-MGC_LOAD
  IMAGE:8368745 IMAGE-MGC_LOAD
InterPro Run UniProtKB/TrEMBL
  Run_dom_sf UniProtKB/TrEMBL
  RUN_RUNDC3A UniProtKB/TrEMBL
  RUNDC3A_B UniProtKB/TrEMBL
KEGG Report rno:303569 UniProtKB/TrEMBL
MGC_CLONE MGC:156558 IMAGE-MGC_LOAD
  MGC:187305 IMAGE-MGC_LOAD
NCBI Gene 303569 ENTREZGENE
PANTHER RUN DOMAIN-CONTAINING 3 PROTEIN RUNDC3 UniProtKB/TrEMBL
  RUN DOMAIN-CONTAINING PROTEIN 3A UniProtKB/TrEMBL
Pfam RUN UniProtKB/TrEMBL
PhenoGen Rundc3a PhenoGen
PROSITE RUN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020970 RatGTEx
SMART RUN UniProtKB/TrEMBL
Superfamily-SCOP SSF140741 UniProtKB/TrEMBL
UniProt A0A0G2JW67 ENTREZGENE, UniProtKB/TrEMBL
  A1L117 ENTREZGENE, UniProtKB/TrEMBL
  A6HJI8 ENTREZGENE, UniProtKB/TrEMBL
  A6HJI9 ENTREZGENE, UniProtKB/TrEMBL
  F1LRZ9 ENTREZGENE, UniProtKB/TrEMBL
  Q9EQ72_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-10 Rundc3a  RUN domain containing 3A  Rap2ip  Rap2 interacting protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Rap2ip  Rap2 interacting protein  GCRP  guanylate-cyclase regulatory protein  Symbol and Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization in PC12 cells, the protein resides in the cytosol until treatment with ANF when it moves toward the plasma membrane 1299631
gene_expression of tissues tested, expression was highest in brain, liver and lung, and lower but detectable in spleen, kidney and heart; no expression was found in prostate 1299631