Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Rdh16 | Rat | 17beta-estradiol | decreases expression | ISO | RDH16 (Homo sapiens) | 6480464 | Estradiol results in decreased expression of RDH16 mRNA | CTD | PMID:20106945 | Rdh16 | Rat | 17beta-estradiol | multiple interactions | ISO | RDH16 (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in increased expression of RDH16 mRNA | CTD | PMID:30165855 | Rdh16 | Rat | 17beta-hydroxy-5alpha-androstan-3-one | multiple interactions | EXP | | 6480464 | [RDH16 protein results in increased metabolism of Androstane-3 and 17-diol] which results in increased chemical synthesis of Dihydrotestosterone | CTD | PMID:28535922 | Rdh16 | Rat | 17beta-hydroxy-5alpha-androstan-3-one | increases chemical synthesis | EXP | | 6480464 | RDH16 protein results in increased chemical synthesis of Dihydrotestosterone | CTD | PMID:28535922 | Rdh16 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of RDH2 mRNA] | CTD | PMID:21215274 | Rdh16 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RDH16 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin affects the expression of RDH16 mRNA | CTD | PMID:22298810 | Rdh16 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RDH16 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of RDH16 mRNA | CTD | PMID:20106945 and PMID:26159488 | Rdh16 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of RDH2 mRNA | CTD | PMID:22298810 | Rdh16 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of RDH2 mRNA | CTD | PMID:21215274 | Rdh16 | Rat | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of RDH16 mRNA | CTD | PMID:31881176 | Rdh16 | Rat | aflatoxin B1 | affects expression | ISO | RDH16 (Homo sapiens) | 6480464 | Aflatoxin B1 affects the expression of RDH16 protein | CTD | PMID:20106945 | Rdh16 | Rat | aflatoxin B1 | decreases expression | ISO | RDH16 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased expression of RDH16 mRNA | CTD | PMID:22100608 and PMID:27153756 | Rdh16 | Rat | aflatoxin B1 | decreases methylation | ISO | RDH16 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of RDH16 exon and Aflatoxin B1 results in decreased methylation of RDH16 gene | CTD | PMID:27153756 and PMID:30157460 | Rdh16 | Rat | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of RDH2 mRNA | CTD | PMID:16483693 | Rdh16 | Rat | androstane-3,17-diol | increases metabolic processing | EXP | | 6480464 | RDH16 protein results in increased metabolism of Androstane-3 and 17-diol | CTD | PMID:28535922 | Rdh16 | Rat | androstane-3,17-diol | multiple interactions | EXP | | 6480464 | [RDH16 protein results in increased metabolism of Androstane-3 and 17-diol] which results in increased chemical synthesis of Dihydrotestosterone | CTD | PMID:28535922 | Rdh16 | Rat | benzo[a]pyrene | decreases expression | ISO | RDH16 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of RDH16 mRNA | CTD | PMID:20106945 more ... | Rdh16 | Rat | benzo[a]pyrene | increases methylation | ISO | RDH16 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of RDH16 3' UTR and Benzo(a)pyrene results in increased methylation of RDH16 promoter | CTD | PMID:27901495 | Rdh16 | Rat | benzo[a]pyrene | decreases methylation | ISO | RDH16 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of RDH16 exon | CTD | PMID:27901495 | Rdh16 | Rat | bexarotene | increases expression | EXP | | 6480464 | bexarotene results in increased expression of RDH2 mRNA | CTD | PMID:16648578 | Rdh16 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of RDH16 mRNA | CTD | PMID:25181051 and PMID:34947998 | Rdh16 | Rat | bisphenol A | increases expression | ISO | RDH16 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of RDH16 mRNA | CTD | PMID:31715268 | Rdh16 | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of RDH16 mRNA | CTD | PMID:30903817 | Rdh16 | Rat | cefaloridine | decreases expression | EXP | | 6480464 | Cephaloridine results in decreased expression of RDH2 mRNA | CTD | PMID:18500788 | Rdh16 | Rat | chenodeoxycholic acid | multiple interactions | ISO | RDH16 (Homo sapiens) | 6480464 | [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt] results in decreased expression of RDH16 mRNA more ... | CTD | PMID:33819548 | Rdh16 | Rat | Cuprizon | increases expression | EXP | | 6480464 | Cuprizone results in increased expression of RDH16 mRNA | CTD | PMID:26577399 | Rdh16 | Rat | cyclosporin A | decreases expression | ISO | RDH16 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of RDH16 mRNA | CTD | PMID:20106945 | Rdh16 | Rat | cyclosporin A | multiple interactions | ISO | RDH16 (Homo sapiens) | 6480464 | [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Cyclosporine] results in decreased expression of RDH16 mRNA | CTD | PMID:33819548 | Rdh16 | Rat | DDE | increases expression | ISO | RDH16 (Homo sapiens) | 6480464 | Dichlorodiphenyl Dichloroethylene results in increased expression of RDH16 mRNA | CTD | PMID:38568856 | Rdh16 | Rat | deoxycholic acid | multiple interactions | ISO | RDH16 (Homo sapiens) | 6480464 | [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt] results in decreased expression of RDH16 mRNA more ... | CTD | PMID:33819548 | Rdh16 | Rat | dexamethasone | multiple interactions | EXP | | 6480464 | Dexamethasone inhibits the reaction [Freund's Adjuvant results in decreased expression of RDH2 mRNA] | CTD | PMID:21149847 | Rdh16 | Rat | Dibutyl phosphate | affects expression | ISO | RDH16 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of RDH16 mRNA | CTD | PMID:37042841 | Rdh16 | Rat | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of RDH16 mRNA | CTD | PMID:24793618 | Rdh16 | Rat | glafenine | decreases expression | EXP | | 6480464 | Glafenine results in decreased expression of RDH2 mRNA | CTD | PMID:24136188 | Rdh16 | Rat | glutathione | increases expression | EXP | | 6480464 | Glutathione deficiency results in increased expression of RDH2 mRNA | CTD | PMID:15345336 | Rdh16 | Rat | glycochenodeoxycholic acid | multiple interactions | ISO | RDH16 (Homo sapiens) | 6480464 | [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt] results in decreased expression of RDH16 mRNA more ... | CTD | PMID:33819548 | Rdh16 | Rat | glycocholic acid | multiple interactions | ISO | RDH16 (Homo sapiens) | 6480464 | [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt] results in decreased expression of RDH16 mRNA more ... | CTD | PMID:33819548 | Rdh16 | Rat | glycodeoxycholic acid | multiple interactions | ISO | RDH16 (Homo sapiens) | 6480464 | [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt] results in decreased expression of RDH16 mRNA more ... | CTD | PMID:33819548 | Rdh16 | Rat | Lasiocarpine | decreases expression | ISO | RDH16 (Homo sapiens) | 6480464 | lasiocarpine results in decreased expression of RDH16 mRNA | CTD | PMID:32234424 | Rdh16 | Rat | N-nitrosodimethylamine | decreases expression | EXP | | 6480464 | Dimethylnitrosamine results in decreased expression of RDH2 mRNA | CTD | PMID:17072980 | Rdh16 | Rat | N-Nitrosopyrrolidine | decreases expression | ISO | RDH16 (Homo sapiens) | 6480464 | N-Nitrosopyrrolidine results in decreased expression of RDH16 mRNA | CTD | PMID:32234424 | Rdh16 | Rat | NAD zwitterion | multiple interactions | ISO | RDH16 (Homo sapiens) | 6480464 | NAD binds to and results in increased activity of RDH16 protein | CTD | PMID:25526675 | Rdh16 | Rat | NAD(+) | multiple interactions | ISO | RDH16 (Homo sapiens) | 6480464 | NAD binds to and results in increased activity of RDH16 protein | CTD | PMID:25526675 | Rdh16 | Rat | nefazodone | multiple interactions | ISO | RDH16 (Homo sapiens) | 6480464 | [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with nefazodone] results in decreased expression of RDH16 mRNA | CTD | PMID:33819548 | Rdh16 | Rat | O-methyleugenol | decreases expression | ISO | RDH16 (Homo sapiens) | 6480464 | methyleugenol results in decreased expression of RDH16 mRNA | CTD | PMID:32234424 | Rdh16 | Rat | paracetamol | increases expression | ISO | RDH16 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of RDH16 mRNA | CTD | PMID:21420995 | Rdh16 | Rat | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of RDH16 mRNA | CTD | PMID:33387578 | Rdh16 | Rat | paracetamol | multiple interactions | ISO | RDH16 (Homo sapiens) | 6480464 | [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen] results in decreased expression of RDH16 mRNA | CTD | PMID:33819548 | Rdh16 | Rat | paracetamol | decreases expression | ISO | RDH16 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of RDH16 mRNA | CTD | PMID:29067470 | Rdh16 | Rat | perfluorononanoic acid | decreases expression | ISO | RDH16 (Homo sapiens) | 6480464 | perfluoro-n-nonanoic acid results in decreased expression of RDH16 mRNA | CTD | PMID:32588087 | Rdh16 | Rat | perfluorooctane-1-sulfonic acid | decreases activity | EXP | | 6480464 | perfluorooctane sulfonic acid results in decreased activity of RDH16 protein | CTD | PMID:28535922 | Rdh16 | Rat | perfluorooctanoic acid | increases expression | EXP | | 6480464 | perfluorooctanoic acid results in increased expression of RDH2 mRNA | CTD | PMID:19162173 | Rdh16 | Rat | perfluorooctanoic acid | decreases activity | EXP | | 6480464 | perfluorooctanoic acid results in decreased activity of RDH16 protein | CTD | PMID:28535922 | Rdh16 | Rat | prednisolone | multiple interactions | EXP | | 6480464 | Prednisolone inhibits the reaction [Freund's Adjuvant results in decreased expression of RDH2 mRNA] | CTD | PMID:21149847 | Rdh16 | Rat | resveratrol | multiple interactions | EXP | | 6480464 | [resveratrol co-treated with Streptozocin] results in decreased expression of RDH2 mRNA | CTD | PMID:25905778 | Rdh16 | Rat | sodium arsenite | decreases expression | ISO | RDH16 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of RDH16 mRNA | CTD | PMID:29301061 and PMID:38568856 | Rdh16 | Rat | streptozocin | multiple interactions | EXP | | 6480464 | [resveratrol co-treated with Streptozocin] results in decreased expression of RDH2 mRNA | CTD | PMID:25905778 | Rdh16 | Rat | Sunset Yellow FCF | multiple interactions | ISO | RDH16 (Homo sapiens) | 6480464 | [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt] results in decreased expression of RDH16 mRNA | CTD | PMID:33819548 | Rdh16 | Rat | tartrazine | multiple interactions | ISO | RDH16 (Homo sapiens) | 6480464 | [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine] results in decreased expression of RDH16 mRNA | CTD | PMID:33819548 | Rdh16 | Rat | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of RDH16 mRNA | CTD | PMID:23411599 and PMID:34492290 | Rdh16 | Rat | thiram | decreases expression | ISO | RDH16 (Homo sapiens) | 6480464 | Thiram results in decreased expression of RDH16 mRNA | CTD | PMID:38568856 | Rdh16 | Rat | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of RDH16 mRNA | CTD | PMID:33387578 | Rdh16 | Rat | Triptolide | increases expression | EXP | | 6480464 | triptolide results in increased expression of RDH2 protein | CTD | PMID:32519852 | Rdh16 | Rat | valproic acid | decreases expression | ISO | RDH16 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of RDH16 mRNA | CTD | PMID:29154799 and PMID:29501571 | Rdh16 | Rat | valproic acid | affects splicing | EXP | | 6480464 | Valproic Acid affects the splicing of RDH16 mRNA | CTD | PMID:29427782 | |