Ripk3 (receptor-interacting serine-threonine kinase 3) - Rat Genome Database

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Gene: Ripk3 (receptor-interacting serine-threonine kinase 3) Mus musculus
Analyze
Symbol: Ripk3
Name: receptor-interacting serine-threonine kinase 3
RGD ID: 734463
MGI Page MGI
Description: Enables protein serine/threonine kinase activity. Involved in several processes, including execution phase of necroptosis; hematopoietic or lymphoid organ development; and positive regulation of necroptotic process. Acts upstream of or within with a positive effect on non-canonical NF-kappaB signal transduction. Acts upstream of or within several processes, including positive regulation of intrinsic apoptotic signaling pathway; positive regulation of ligase activity; and positive regulation of oxidoreductase activity. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; immune system; male reproductive gland or organ; and turbinate bone primordium. Orthologous to human RIPK3 (receptor interacting serine/threonine kinase 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2610528K09Rik; AW107945; mRIP3; R; receptor interacting protein 3; receptor-interacting protein 3; receptor-interacting serine/threonine-protein kinase 3; RIP-3; RIP-like protein kinase 3; Rip3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
NCBI Annotation Information: Note: Mprip (Gene ID: 26936) and Ripk3 (Gene ID: 56532) share the RIP3 symbol/alias in common. RIP3 is a widely used alternative name for Ripk3 (Gene ID: 56532), which can be confused with Mprip (Gene ID: 26936), which also uses RIP3 as an alternative name. [05 Mar 2019]
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391456,022,452 - 56,026,314 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1456,022,452 - 56,026,322 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381455,784,995 - 55,788,857 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1455,784,995 - 55,788,865 (-)Ensemblmm10GRCm38
MGSCv371456,403,832 - 56,407,694 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361454,739,068 - 54,742,857 (-)NCBIMGSCv36mm8
Celera1453,590,028 - 53,593,890 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.19NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
1,3-dichloropropan-2-ol  (EXP,ISO)
1-monopalmitoylglycerol  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (ISO)
2-acetamidofluorene  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (EXP,ISO)
3-methyladenine  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5,7-dihydroxy-4'-methoxyflavone  (ISO)
5-Isoxazoleacetic acid, 4,5-dihydro-3-(4-hydroxyphenyl)-, methyl ester  (EXP)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (ISO)
acetamide  (ISO)
acrolein  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
amosite asbestos  (ISO)
amphetamine  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
betaxolol  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bortezomib  (EXP)
butanal  (ISO)
butane-2,3-dione  (EXP)
C.I. Natural Red 20  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
captopril  (ISO)
carbon nanotube  (EXP)
carbonyl sulfide  (ISO)
CGP 52608  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
D-glucose  (ISO)
D-penicillamine  (EXP)
dextran sulfate  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
Dihydrotanshinone I  (EXP)
dimethyl fumarate  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (EXP,ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
eritoran  (EXP)
ethanol  (EXP,ISO)
ferric oxide  (ISO)
fingolimod hydrochloride  (ISO)
folic acid  (EXP,ISO)
fulvestrant  (ISO)
fumonisin B1  (EXP)
galangin  (ISO)
gallic acid  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glucose  (ISO)
glycerol  (ISO)
glycidol  (ISO)
GSK-J4  (ISO)
hydrogen peroxide  (EXP,ISO)
isoprenaline  (ISO)
lipopolysaccharide  (EXP)
lycopene  (ISO)
melatonin  (EXP,ISO)
metformin  (ISO)
methapyrilene  (ISO)
methimazole  (ISO)
methoxyacetic acid  (ISO)
methylarsonic acid  (EXP)
methylmercury chloride  (ISO)
minocycline  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-phosphocreatine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
ochratoxin A  (EXP)
oleic acid  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (EXP)
phenacetin  (ISO)
phenylephrine  (ISO)
phenylhydrazine  (ISO)
phenylpropanolamine  (ISO)
pirinixic acid  (EXP,ISO)
Pranoprofen  (ISO)
pterostilbene  (ISO)
quetiapine fumarate  (EXP)
rac-1-monopalmitoylglycerol  (ISO)
reactive oxygen species  (EXP)
resveratrol  (EXP)
rimonabant  (EXP)
rotenone  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
sevoflurane  (EXP)
Shikonin  (EXP)
silicon dioxide  (EXP)
simvastatin  (ISO)
SM-164  (EXP,ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP)
sodium dichromate  (EXP,ISO)
sulfadimethoxine  (ISO)
T-2 toxin  (ISO)
tamoxifen  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP)
theophylline  (ISO)
thioacetamide  (ISO)
thymoquinone  (ISO)
titanium dioxide  (EXP)
Tributyltin oxide  (ISO)
tricalcium bis(phosphate)  (EXP)
triclosan  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase activity  (ISO,ISS)
amyloid fibril formation  (IEA,ISO,ISS)
apoptotic process  (IEA)
cellular response to hydrogen peroxide  (IMP)
defense response to virus  (IDA,IMP)
execution phase of necroptosis  (IMP,ISO)
lymph node development  (IGI)
necroptotic process  (IEA,IGI,IMP,ISO)
necroptotic signaling pathway  (IEA,ISO)
non-canonical NF-kappaB signal transduction  (IMP)
positive regulation of intrinsic apoptotic signaling pathway  (IDA)
positive regulation of ligase activity  (IDA)
positive regulation of metabolic process  (IEA)
positive regulation of necroptotic process  (IDA,IEA,IMP,ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of oxidoreductase activity  (IDA)
positive regulation of reactive oxygen species metabolic process  (IMP)
positive regulation of transferase activity  (IGI)
programmed cell death  (IEA)
programmed necrotic cell death  (IMP)
reactive oxygen species metabolic process  (IMP)
regulation of activated T cell proliferation  (IGI)
regulation of activation-induced cell death of T cells  (IGI)
regulation of adaptive immune response  (IGI)
regulation of apoptotic process  (IDA,IMP)
regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation  (IGI)
regulation of gene expression  (IEA)
regulation of reactive oxygen species metabolic process  (IMP)
regulation of T cell mediated cytotoxicity  (IGI)
regulation of type II interferon production  (IGI)
signal transduction  (IBA,IEA)
spleen development  (IGI)
T cell differentiation in thymus  (IGI)
T cell homeostasis  (IGI)
thymus development  (IGI)

Cellular Component
cytoplasm  (IBA,IDA,IEA)
cytosol  (IEA,ISO,ISS)
nucleus  (IDA,IEA,ISO)
protein-containing complex  (IEA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal crypts of Lieberkuhn morphology  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal intestine physiology  (IAGP)
abnormal kidney morphology  (IEA)
abnormal liver physiology  (IAGP)
abnormal lymphocyte morphology  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal visceral yolk sac blood island morphology  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
absent vibrissae  (IEA)
blunted small intestinal villi  (IAGP)
decreased B cell number  (IAGP)
decreased body size  (IAGP)
decreased hematopoietic cell number  (IAGP)
decreased hepatocyte apoptosis  (IAGP)
decreased inflammatory response  (IAGP)
decreased leukocyte cell number  (IAGP)
decreased liver glycogen level  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased macrophage apoptosis  (IAGP)
decreased mature B cell number  (IAGP)
decreased sensitivity to induced cell death  (IAGP)
decreased susceptibility to induced morbidity/mortality  (IAGP)
decreased susceptibility to induced pancreatitis  (IAGP)
decreased T cell number  (IAGP)
decreased thymocyte apoptosis  (IAGP)
diarrhea  (IAGP)
embryonic growth arrest  (IAGP)
embryonic lethality  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality prior to tooth bud stage  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged axillary lymph nodes  (IAGP)
enlarged cervical lymph nodes  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
enlarged thymus  (IAGP)
fused small intestinal villi  (IAGP)
increased B cell number  (IAGP)
increased CD11b-high dendritic cell number  (IAGP)
increased granulocyte number  (IAGP)
increased inflammatory response  (IAGP)
increased leukocyte cell number  (IAGP)
increased macrophage cell number  (IAGP)
increased spleen white pulp amount  (IAGP)
increased T cell number  (IAGP)
intestinal edema  (IAGP)
intestinal inflammation  (IAGP)
large lymphoid organs  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lymph node hyperplasia  (IAGP)
neonatal lethality  (IAGP)
no abnormal phenotype detected  (IEA)
pallor  (IAGP)
preweaning lethality, complete penetrance  (IAGP)
scaly skin  (IAGP)
skin lesions  (IAGP)
thymus atrophy  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. RIPK3 Promotes JEV Replication in Neurons via Downregulation of IFI44L. Bian P, etal., Front Microbiol. 2020 Mar 24;11:368. doi: 10.3389/fmicb.2020.00368. eCollection 2020.
2. The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation. Bonnet MC, etal., Immunity. 2011 Oct 28;35(4):572-82. doi: 10.1016/j.immuni.2011.08.014. Epub 2011 Oct 13.
3. Dectin-1-induced RIPK1 and RIPK3 activation protects host against Candida albicans infection. Cao M, etal., Cell Death Differ. 2019 Dec;26(12):2622-2636. doi: 10.1038/s41418-019-0323-8. Epub 2019 Apr 3.
4. RIPK3 collaborates with GSDMD to drive tissue injury in lethal polymicrobial sepsis. Chen H, etal., Cell Death Differ. 2020 Sep;27(9):2568-2585. doi: 10.1038/s41418-020-0524-1. Epub 2020 Mar 9.
5. Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cho YS, etal., Cell. 2009 Jun 12;137(6):1112-23. doi: 10.1016/j.cell.2009.05.037.
6. Mitochondrial antiviral signaling protein defect links impaired antiviral response and liver injury in steatohepatitis in mice. Csak T, etal., Hepatology. 2011 Jun;53(6):1917-31. doi: 10.1002/hep.24301. Epub 2011 May 2.
7. RIPK3 interacts with MAVS to regulate type I IFN-mediated immunity to Influenza A virus infection. Downey J, etal., PLoS Pathog. 2017 Apr 14;13(4):e1006326. doi: 10.1371/journal.ppat.1006326. eCollection 2017 Apr.
8. RIP kinase-dependent necrosis drives lethal systemic inflammatory response syndrome. Duprez L, etal., Immunity. 2011 Dec 23;35(6):908-18. doi: 10.1016/j.immuni.2011.09.020.
9. Pore-forming toxin-mediated ion dysregulation leads to death receptor-independent necroptosis of lung epithelial cells during bacterial pneumonia. González-Juarbe N, etal., Cell Death Differ. 2017 May;24(5):917-928. doi: 10.1038/cdd.2017.49. Epub 2017 Apr 7.
10. Species-independent contribution of ZBP1/DAI/DLM-1-triggered necroptosis in host defense against HSV1. Guo H, etal., Cell Death Dis. 2018 Jul 26;9(8):816. doi: 10.1038/s41419-018-0868-3.
11. Receptor-Interacting Protein Kinase 3 (RIPK3) mRNA Levels Are Elevated in Blood Mononuclear Cells of Patients with Poor Prognosis of Acute-on-Chronic Hepatitis B Liver Failure. Han L, etal., Tohoku J Exp Med. 2019 Apr;247(4):237-245. doi: 10.1620/tjem.247.237.
12. RIPK3 Activates MLKL-mediated Necroptosis and Inflammasome Signaling during Streptococcus Infection. Huang HR, etal., Am J Respir Cell Mol Biol. 2021 May;64(5):579-591. doi: 10.1165/rcmb.2020-0312OC.
13. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
14. Necroptosis Promotes Staphylococcus aureus Clearance by Inhibiting Excessive Inflammatory Signaling. Kitur K, etal., Cell Rep. 2016 Aug 23;16(8):2219-2230. doi: 10.1016/j.celrep.2016.07.039. Epub 2016 Aug 11.
15. Transcription modulation by CDK9 regulates inflammatory genes and RIPK3-MLKL-mediated necroptosis in periodontitis progression. Li J, etal., Sci Rep. 2019 Nov 22;9(1):17369. doi: 10.1038/s41598-019-53910-y.
16. Immature mice are more susceptible than adult mice to acetaminophen-induced acute liver injury. Lu Y, etal., Sci Rep. 2017 Feb 16;7:42736. doi: 10.1038/srep42736.
17. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
18. MGDs mouse GO annotations MGD data from the GO Consortium
19. MGD IEA MGD IEA
20. Programmed necrosis, not apoptosis, is a key mediator of cell loss and DAMP-mediated inflammation in dsRNA-induced retinal degeneration. Murakami Y, etal., Cell Death Differ. 2013 Aug 16. doi: 10.1038/cdd.2013.109.
21. Receptor interacting protein kinase mediates necrotic cone but not rod cell death in a mouse model of inherited degeneration. Murakami Y, etal., Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14598-603. doi: 10.1073/pnas.1206937109. Epub 2012 Aug 20.
22. Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4. Newton K, etal., Mol Cell Biol 2004 Feb;24(4):1464-9.
23. RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus. Nogusa S, etal., Cell Host Microbe. 2016 Jul 13;20(1):13-24. doi: 10.1016/j.chom.2016.05.011. Epub 2016 Jun 16.
24. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
25. Close Relationship between cIAP2 and Human ARDS Induced by Severe H7N9 Infection. Qin C, etal., Biomed Res Int. 2019 Apr 7;2019:2121357. doi: 10.1155/2019/2121357. eCollection 2019.
26. Mouse MP Annotation Import Pipeline RGD automated import pipeline
27. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. Necroptosis mediators RIPK3 and MLKL suppress intracellular Listeria replication independently of host cell killing. Sai K, etal., J Cell Biol. 2019 Jun 3;218(6):1994-2005. doi: 10.1083/jcb.201810014. Epub 2019 Apr 11.
30. TNF-mediated alveolar macrophage necroptosis drives disease pathogenesis during Respiratory Syncytial Virus infection. Santos LD, etal., Eur Respir J. 2020 Dec 10. pii: 13993003.03764-2020. doi: 10.1183/13993003.03764-2020.
31. Loss of periodontal ligament fibroblasts by RIPK3-MLKL-mediated necroptosis in the progress of chronic periodontitis. Shi J, etal., Sci Rep. 2019 Feb 27;9(1):2902. doi: 10.1038/s41598-019-39721-1.
32. Is Receptor-Interacting Protein Kinase 3 a Viable Therapeutic Target for Mycobacterium tuberculosis Infection? Stutz MD, etal., Front Immunol. 2018 May 28;9:1178. doi: 10.3389/fimmu.2018.01178. eCollection 2018.
33. RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway. Wang X, etal., Nat Immunol. 2014 Dec;15(12):1126-33. doi: 10.1038/ni.3015. Epub 2014 Oct 19.
34. Direct activation of RIP3/MLKL-dependent necrosis by herpes simplex virus 1 (HSV-1) protein ICP6 triggers host antiviral defense. Wang X, etal., Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15438-43. doi: 10.1073/pnas.1412767111. Epub 2014 Oct 14.
35. RIP1 kinase activity is critical for skin inflammation but not for viral propagation. Webster JD, etal., J Leukoc Biol. 2020 Jun;107(6):941-952. doi: 10.1002/JLB.3MA1219-398R. Epub 2020 Jan 27.
36. Adjunctive dexamethasone therapy improves lung injury by inhibiting inflammation and reducing RIP3 expression during Staphylococcus aureus pneumonia in mice. Wen SH, etal., Int Immunopharmacol. 2014 Dec;23(2):709-18. doi: 10.1016/j.intimp.2014.10.027.
37. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
38. Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis. Wu J, etal., Cell Res. 2013 Aug;23(8):994-1006. doi: 10.1038/cr.2013.91. Epub 2013 Jul 9.
39. Depletion of the Receptor-Interacting Protein Kinase 3 (RIP3) Decreases Photoreceptor Cell Death During the Early Stages of Ocular Murine Cytomegalovirus Infection. Xu J, etal., Invest Ophthalmol Vis Sci. 2018 May 1;59(6):2445-2458. doi: 10.1167/iovs.18-24086.
40. Inflammation and outer blood-retina barrier (BRB) compromise following choroidal murine cytomegalovirus (MCMV) infections. Xu J, etal., Mol Vis. 2018 May 18;24:379-394. eCollection 2018.
41. RIP3 deficiency ameliorates inflammatory response in mice infected with influenza H7N9 virus infection. Xu YL, etal., Oncotarget. 2017 Apr 25;8(17):27715-27724. doi: 10.18632/oncotarget.16016.
42. Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis. Zhang T, etal., Cell. 2020 Mar 19;180(6):1115-1129.e13. doi: 10.1016/j.cell.2020.02.050.
43. Bcl-xL mediates RIPK3-dependent necrosis in M. tuberculosis-infected macrophages. Zhao X, etal., Mucosal Immunol. 2017 Nov;10(6):1553-1568. doi: 10.1038/mi.2017.12. Epub 2017 Apr 12.
Additional References at PubMed
PMID:10349636   PMID:10490590   PMID:11042159   PMID:11076861   PMID:12477932   PMID:15064760   PMID:16141072   PMID:16141073   PMID:18533105   PMID:18973680   PMID:19498109   PMID:19524512  
PMID:19590578   PMID:20413098   PMID:21052097   PMID:21098270   PMID:21267068   PMID:21368761   PMID:21368762   PMID:21368763   PMID:21402742   PMID:21677750   PMID:21804564   PMID:21873635  
PMID:21876153   PMID:21903422   PMID:21949016   PMID:22037414   PMID:22123964   PMID:22193709   PMID:22262768   PMID:22265413   PMID:22265414   PMID:22266724   PMID:22327219   PMID:22365665  
PMID:22423968   PMID:22555457   PMID:22675671   PMID:22814620   PMID:22819539   PMID:22922364   PMID:22942356   PMID:23071110   PMID:23144495   PMID:23201261   PMID:23260196   PMID:23260419  
PMID:23333278   PMID:23584955   PMID:23612963   PMID:23708968   PMID:23727238   PMID:23744808   PMID:23818611   PMID:23846218   PMID:23972991   PMID:24012422   PMID:24019532   PMID:24036366  
PMID:24059293   PMID:24078693   PMID:24095729   PMID:24103001   PMID:24174679   PMID:24194600   PMID:24210353   PMID:24434512   PMID:24439895   PMID:24441827   PMID:24453211   PMID:24453255  
PMID:24489101   PMID:24497535   PMID:24535827   PMID:24556404   PMID:24557836   PMID:24572428   PMID:24577084   PMID:24703947   PMID:24746856   PMID:24799678   PMID:24799700   PMID:24808358  
PMID:24813849   PMID:24813850   PMID:24821786   PMID:24842373   PMID:24874734   PMID:24882010   PMID:24901049   PMID:24902899   PMID:24920296   PMID:24963148   PMID:24984764   PMID:24990442  
PMID:24996547   PMID:25015821   PMID:25049377   PMID:25132550   PMID:25186904   PMID:25246544   PMID:25274309   PMID:25278099   PMID:25288762   PMID:25301392   PMID:25327580   PMID:25348793  
PMID:25367573   PMID:25423287   PMID:25443631   PMID:25450619   PMID:25459880   PMID:25500368   PMID:25563840   PMID:25567679   PMID:25575566   PMID:25607459   PMID:25674205   PMID:25674982  
PMID:25693118   PMID:25704009   PMID:25748555   PMID:25751141   PMID:25767797   PMID:25788533   PMID:25801023   PMID:25824823   PMID:25874713   PMID:25882049   PMID:25906154   PMID:25939025  
PMID:25950489   PMID:26024392   PMID:26037070   PMID:26061004   PMID:26086143   PMID:26100631   PMID:26104484   PMID:26238997   PMID:26269257   PMID:26283397   PMID:26283547   PMID:26288377  
PMID:26375003   PMID:26381214   PMID:26451737   PMID:26463424   PMID:26471282   PMID:26531064   PMID:26549703   PMID:26555174   PMID:26559832   PMID:26649818   PMID:26726877   PMID:26752649  
PMID:26769846   PMID:26817517   PMID:26842216   PMID:26859455   PMID:26900751   PMID:26969469   PMID:26982364   PMID:26995086   PMID:26998763   PMID:27007676   PMID:27049944   PMID:27071119  
PMID:27160902   PMID:27177019   PMID:27195494   PMID:27258785   PMID:27258786   PMID:27323669   PMID:27344176   PMID:27391363   PMID:27396959   PMID:27411587   PMID:27487218   PMID:27493188  
PMID:27498868   PMID:27523270   PMID:27532042   PMID:27560715   PMID:27561390   PMID:27584790   PMID:27616656   PMID:27626380   PMID:27640145   PMID:27669412   PMID:27737018   PMID:27746097  
PMID:27756058   PMID:27819681   PMID:27819682   PMID:27840306   PMID:27856241   PMID:27917412   PMID:27998728   PMID:28017612   PMID:28060376   PMID:28096356   PMID:28151480   PMID:28176780  
PMID:28182011   PMID:28242694   PMID:28256024   PMID:28273458   PMID:28342910   PMID:28346226   PMID:28366204   PMID:28410990   PMID:28410991   PMID:28428949   PMID:28445730   PMID:28461567  
PMID:28537251   PMID:28564603   PMID:28572508   PMID:28574501   PMID:28607035   PMID:28660207   PMID:28661484   PMID:28666573   PMID:28686578   PMID:28694385   PMID:28703808   PMID:28724891  
PMID:28732308   PMID:28807105   PMID:28842570   PMID:28898696   PMID:28919893   PMID:28978351   PMID:29055012   PMID:29078325   PMID:29089374   PMID:29167229   PMID:29203883   PMID:29212904  
PMID:29229992   PMID:29238045   PMID:29244050   PMID:29248164   PMID:29262324   PMID:29358703   PMID:29413844   PMID:29415885   PMID:29434332   PMID:29470982   PMID:29491424   PMID:29500178  
PMID:29502045   PMID:29524460   PMID:29527209   PMID:29560122   PMID:29588419   PMID:29596938   PMID:29634408   PMID:29654209   PMID:29661823   PMID:29666472   PMID:29686269   PMID:29695863  
PMID:29720570   PMID:29746630   PMID:29770487   PMID:29786074   PMID:29875323   PMID:29883609   PMID:29930103   PMID:29950720   PMID:29996103   PMID:30012671   PMID:30021146   PMID:30126430  
PMID:30131368   PMID:30146158   PMID:30165576   PMID:30175514   PMID:30181240   PMID:30185824   PMID:30192300   PMID:30194111   PMID:30194302   PMID:30254289   PMID:30280195   PMID:30341420  
PMID:30344099   PMID:30361383   PMID:30381458   PMID:30420664   PMID:30423296   PMID:30442927   PMID:30451870   PMID:30485804   PMID:30485805   PMID:30635240   PMID:30683688   PMID:30683914  
PMID:30692261   PMID:30703581   PMID:30741936   PMID:30755477   PMID:30770249   PMID:30815534   PMID:30830879   PMID:30837313   PMID:30842945   PMID:30988397   PMID:31000631   PMID:31026418  
PMID:31086261   PMID:31101885   PMID:31132747   PMID:31133359   PMID:31141691   PMID:31147458   PMID:31227597   PMID:31230859   PMID:31235857   PMID:31243089   PMID:31251782   PMID:31257491  
PMID:31285326   PMID:31295018   PMID:31296735   PMID:31352002   PMID:31358656   PMID:31430539   PMID:31454332   PMID:31461645   PMID:31462647   PMID:31506635   PMID:31511692   PMID:31519886  
PMID:31519887   PMID:31659279   PMID:31665609   PMID:31685620   PMID:31690718   PMID:31719149   PMID:31723262   PMID:31801942   PMID:31819256   PMID:31848486   PMID:31869420   PMID:31944526  
PMID:31953345   PMID:31961824   PMID:31968247   PMID:31988496   PMID:32071228   PMID:32094226   PMID:32119761   PMID:32182211   PMID:32193329   PMID:32232483   PMID:32247850   PMID:32268091  
PMID:32273498   PMID:32296175   PMID:32298652   PMID:32315377   PMID:32321638   PMID:32362323   PMID:32366477   PMID:32428502   PMID:32433961   PMID:32515732   PMID:32542792   PMID:32554809  
PMID:32555451   PMID:32561755   PMID:32581129   PMID:32591618   PMID:32633835   PMID:32703968   PMID:32726624   PMID:32763970   PMID:32855420   PMID:32895234   PMID:32968282   PMID:32971525  
PMID:32979304   PMID:32989095   PMID:32999468   PMID:33024046   PMID:33109609   PMID:33119828   PMID:33125891   PMID:33126536   PMID:33140051   PMID:33206046   PMID:33221042   PMID:33271062  
PMID:33278357   PMID:33311474   PMID:33389663   PMID:33397971   PMID:33417971   PMID:33444549   PMID:33449298   PMID:33513913   PMID:33712586   PMID:33712742   PMID:33779513   PMID:33833407  
PMID:33836603   PMID:33841405   PMID:33850121   PMID:33854696   PMID:33862457   PMID:33891868   PMID:33976111   PMID:34029184   PMID:34046766   PMID:34103472   PMID:34112763   PMID:34173165  
PMID:34194608   PMID:34281454   PMID:34321999   PMID:34327615   PMID:34374150   PMID:34383769   PMID:34404478   PMID:34437534   PMID:34462571   PMID:34471287   PMID:34544877   PMID:34548542  
PMID:34551300   PMID:34572045   PMID:34625556   PMID:34625557   PMID:34633746   PMID:34648590   PMID:34675436   PMID:34686350   PMID:34687171   PMID:34752416   PMID:34753914   PMID:34778458  
PMID:34811356   PMID:34919140   PMID:34956189   PMID:34986653   PMID:34990405   PMID:35046131   PMID:35064213   PMID:35077396   PMID:35094251   PMID:35101798   PMID:35139355   PMID:35281062  
PMID:35346043   PMID:35351865   PMID:35354912   PMID:35402535   PMID:35417681   PMID:35422482   PMID:35438255   PMID:35671429   PMID:35711363   PMID:35741025   PMID:35781632   PMID:35859176  
PMID:35990890   PMID:36029129   PMID:36030035   PMID:36037995   PMID:36046685   PMID:36121858   PMID:36146839   PMID:36156290   PMID:36161785   PMID:36169895   PMID:36178467   PMID:36329033  
PMID:36367942   PMID:36602874   PMID:36638666   PMID:36650286   PMID:36651749   PMID:36755069   PMID:36774342   PMID:36795486   PMID:36891703   PMID:36912451   PMID:36991017   PMID:37005412  
PMID:37072399   PMID:37150500   PMID:37150671   PMID:37329888   PMID:37516311   PMID:37518945   PMID:37553782   PMID:37566034   PMID:37615626   PMID:37633447   PMID:37691112   PMID:37724400  
PMID:37771598   PMID:37789765   PMID:37792157   PMID:37909859   PMID:37970714   PMID:38000038   PMID:38011306   PMID:38082146   PMID:38161978   PMID:38191748   PMID:38218538   PMID:38355793  
PMID:38409108   PMID:38493248   PMID:38503474   PMID:38522486   PMID:38548850   PMID:38697117   PMID:38788712   PMID:39044278   PMID:39247823   PMID:39500322   PMID:39577420   PMID:39999836  
PMID:40100932   PMID:40128366   PMID:40158217   PMID:40252640   PMID:40267921  


Genomics

Comparative Map Data
Ripk3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391456,022,452 - 56,026,314 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1456,022,452 - 56,026,322 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381455,784,995 - 55,788,857 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1455,784,995 - 55,788,865 (-)Ensemblmm10GRCm38
MGSCv371456,403,832 - 56,407,694 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361454,739,068 - 54,742,857 (-)NCBIMGSCv36mm8
Celera1453,590,028 - 53,593,890 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.19NCBI
RIPK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381424,336,025 - 24,339,991 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1424,336,025 - 24,340,022 (-)Ensemblhg38GRCh38
GRCh371424,805,231 - 24,809,197 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361423,875,067 - 23,879,082 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341423,875,071 - 23,879,013NCBI
Celera144,669,852 - 4,673,867 (-)NCBICelera
Cytogenetic Map14q12NCBI
HuRef144,920,121 - 4,924,136 (-)NCBIHuRef
CHM1_11424,803,822 - 24,807,837 (-)NCBICHM1_1
T2T-CHM13v2.01418,534,370 - 18,538,336 (-)NCBIT2T-CHM13v2.0
Ripk3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81533,253,071 - 33,262,025 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1533,253,071 - 33,262,025 (-)EnsemblGRCr8
mRatBN7.21529,283,153 - 29,292,107 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,283,145 - 29,292,121 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1531,128,833 - 31,137,787 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01532,276,043 - 32,284,997 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01530,518,392 - 30,527,346 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01534,470,796 - 34,479,741 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,470,796 - 34,479,741 (-)Ensemblrn6Rnor6.0
Rnor_5.01538,359,304 - 38,368,247 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41533,947,406 - 33,956,351 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1528,858,091 - 28,867,036 (-)NCBICelera
RGSC_v3.11533,963,105 - 33,972,051 (-)NCBI
Cytogenetic Map15p13NCBI
Ripk3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540935,937,880 - 35,965,712 (+)Ensembl
ChiLan1.0NW_00495540935,961,604 - 35,965,477 (+)NCBIChiLan1.0ChiLan1.0
RIPK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21525,691,137 - 25,695,155 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11424,907,629 - 24,911,596 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0145,112,512 - 5,116,486 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11423,235,796 - 23,239,821 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1423,235,796 - 23,239,821 (-)EnsemblpanPan2panpan1.1
RIPK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,304,167 - 4,309,514 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,305,250 - 4,309,325 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha84,227,031 - 4,231,283 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.084,416,047 - 4,420,326 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl84,416,051 - 4,420,261 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.184,106,383 - 4,110,679 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.084,168,389 - 4,172,700 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.084,430,799 - 4,435,106 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ripk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864036,176,140 - 36,180,016 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936722209,013 - 212,839 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936722209,019 - 212,817 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RIPK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl774,951,145 - 74,955,251 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1774,951,145 - 74,955,255 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2780,222,514 - 80,226,187 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RIPK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1241,318,265 - 1,322,610 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl241,318,216 - 1,322,462 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603613,002,814 - 13,006,980 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ripk3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248208,165,546 - 8,169,172 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Ripk3
146 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:180
Count of miRNA genes:56
Interacting mature miRNAs:59
Transcripts:ENSMUST00000022830, ENSMUST00000168716, ENSMUST00000178399
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1300625Cosz2_mcocaine seizure 2 (mouse)Not determined143504579768785736Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144296241676962593Mouse
1301489Lbm10_mlean body mass 10 (mouse)Not determined145376129687761529Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144296241676962593Mouse
4142364Pbwg18_mpostnatal body weight growth 18 (mouse)Not determined145228198486282125Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144306584777066045Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
4142485Modor2_mmodifier of ocular retardation 2 (mouse)Not determined142492624858179769Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4033731974337319Mouse
27226737Metcl12_mmetatarsal-calcaneal length 12, 10 week (mouse)143322195759437449Mouse
1300605El5_mepilepsy 5 (mouse)Not determined144945542583455556Mouse
1301091Bbaa21_mB.burgdorferi-associated arthritis 21 (mouse)Not determined144306584777066045Mouse
4141484Hcbip1_mhexachlorobenzene induced porphyria 1 (mouse)Not determined4733525059962593Mouse
12880432Fgf23lq3_mFGF23 serum level QTL 3 (mouse)145393744087937440Mouse
1300998Cia17_mcollagen induced arthritis 17 (mouse)Not determined143033525064335381Mouse
10043887Cia50_mcollagen induced arthritis QTL 50 (mouse)Not determined143743018571430320Mouse
1300805Mors3_mmodifier of obesity related sterility 3 (mouse)Not determined144303727077037418Mouse
10043886Cia49_mcollagen induced arthritis QTL 49 (mouse)Not determined142999699463997133Mouse
14746973Manh76_mmandible shape 76 (mouse)142228721756287217Mouse
1300909Ath13_matherosclerosis 13 (mouse)Not determined143033525064335381Mouse
13506929Recrq10_mrecombination rate in male meiosis QTL 10 (mouse)142792195761137449Mouse

Markers in Region
AW107945  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381455,785,044 - 55,785,159UniSTSGRCm38
MGSCv371456,403,881 - 56,403,996UniSTSGRCm37
Celera1453,590,077 - 53,590,192UniSTS
Cytogenetic Map14C1UniSTS
Cytogenetic Map14D3UniSTS
Whitehead/MRC_RH14609.07UniSTS
UniSTS:237189  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381455,785,017 - 55,785,216UniSTSGRCm38
MGSCv371456,403,854 - 56,404,053UniSTSGRCm37
Celera1453,590,050 - 53,590,249UniSTS
Cytogenetic Map14D3UniSTS
Cytogenetic Map14C1UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000022830   ⟹   ENSMUSP00000022830
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1456,022,452 - 56,026,322 (-)Ensembl
GRCm38.p6 Ensembl1455,784,995 - 55,788,865 (-)Ensembl
Ensembl Acc Id: ENSMUST00000168716   ⟹   ENSMUSP00000126306
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1456,022,453 - 56,026,314 (-)Ensembl
GRCm38.p6 Ensembl1455,784,996 - 55,788,857 (-)Ensembl
Ensembl Acc Id: ENSMUST00000178399   ⟹   ENSMUSP00000137278
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1456,022,454 - 56,026,314 (-)Ensembl
GRCm38.p6 Ensembl1455,784,997 - 55,788,857 (-)Ensembl
Ensembl Acc Id: ENSMUST00000226203
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1456,025,732 - 56,026,245 (-)Ensembl
GRCm38.p6 Ensembl1455,788,275 - 55,788,788 (-)Ensembl
Ensembl Acc Id: ENSMUST00000227072
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1456,024,282 - 56,025,576 (-)Ensembl
GRCm38.p6 Ensembl1455,786,825 - 55,788,119 (-)Ensembl
Ensembl Acc Id: ENSMUST00000228077
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1456,022,453 - 56,023,440 (-)Ensembl
GRCm38.p6 Ensembl1455,784,996 - 55,785,983 (-)Ensembl
Ensembl Acc Id: ENSMUST00000228175
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1456,023,882 - 56,024,370 (-)Ensembl
GRCm38.p6 Ensembl1455,786,425 - 55,786,913 (-)Ensembl
Ensembl Acc Id: ENSMUST00000228326   ⟹   ENSMUSP00000154235
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1456,024,583 - 56,025,849 (-)Ensembl
GRCm38.p6 Ensembl1455,787,126 - 55,788,392 (-)Ensembl
Ensembl Acc Id: ENSMUST00000228476   ⟹   ENSMUSP00000153911
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1456,023,222 - 56,023,809 (-)Ensembl
GRCm38.p6 Ensembl1455,785,765 - 55,786,352 (-)Ensembl
RefSeq Acc Id: NM_001164107   ⟹   NP_001157579
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391456,022,452 - 56,026,314 (-)NCBI
GRCm381455,784,995 - 55,788,857 (-)ENTREZGENE
MGSCv371456,403,832 - 56,407,694 (-)RGD
Celera1453,590,028 - 53,593,890 (-)RGD
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001164108   ⟹   NP_001157580
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391456,022,452 - 56,026,314 (-)NCBI
GRCm381455,784,995 - 55,788,857 (-)ENTREZGENE
MGSCv371456,403,832 - 56,407,694 (-)RGD
Celera1453,590,028 - 53,593,890 (-)RGD
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_019955   ⟹   NP_064339
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391456,022,452 - 56,026,314 (-)NCBI
GRCm381455,784,995 - 55,788,857 (-)ENTREZGENE
MGSCv371456,403,832 - 56,407,694 (-)RGD
Celera1453,590,028 - 53,593,890 (-)RGD
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_064339   ⟸   NM_019955
- Peptide Label: isoform 1
- UniProtKB: Q3U3Z9 (UniProtKB/Swiss-Prot),   G3X8V8 (UniProtKB/Swiss-Prot),   Q8K2Y2 (UniProtKB/Swiss-Prot),   Q9QZL0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001157579   ⟸   NM_001164107
- Peptide Label: isoform 2
- UniProtKB: E9PZP3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001157580   ⟸   NM_001164108
- Peptide Label: isoform 2
- UniProtKB: E9PZP3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000137278   ⟸   ENSMUST00000178399
Ensembl Acc Id: ENSMUSP00000154235   ⟸   ENSMUST00000228326
Ensembl Acc Id: ENSMUSP00000126306   ⟸   ENSMUST00000168716
Ensembl Acc Id: ENSMUSP00000022830   ⟸   ENSMUST00000022830
Ensembl Acc Id: ENSMUSP00000153911   ⟸   ENSMUST00000228476
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QZL0-F1-model_v2 AlphaFold Q9QZL0 1-486 view protein structure

Promoters
RGD ID:8682478
Promoter ID:EPDNEW_M19270
Type:initiation region
Name:Ripk3_1
Description:Mus musculus receptor-interacting serine-threonine kinase 3 ,transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381455,788,819 - 55,788,879EPDNEW
RGD ID:6825342
Promoter ID:MM_KWN:16994
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_001164107,   NM_001164108,   NM_019955
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361456,407,424 - 56,407,924 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2154952 AgrOrtholog
Ensembl Genes ENSMUSG00000022221 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000022830 ENTREZGENE
  ENSMUST00000022830.14 UniProtKB/Swiss-Prot
  ENSMUST00000168716 ENTREZGENE
  ENSMUST00000178399 ENTREZGENE
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  RHIM_dom UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
  Ser/Thr_Kinases-Pseudokinases UniProtKB/Swiss-Prot
KEGG Report mmu:56532 UniProtKB/Swiss-Prot
MGD MGI:2154952 ENTREZGENE
NCBI Gene 56532 ENTREZGENE
PANTHER RECEPTOR-INTERACTING SERINE_THREONINE-PROTEIN KINASE 3 UniProtKB/Swiss-Prot
  SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
  RHIM UniProtKB/Swiss-Prot
PhenoGen Ripk3 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A2I3BPT3_MOUSE UniProtKB/TrEMBL
  A0A2I3BQW9_MOUSE UniProtKB/TrEMBL
  E9PZP3 ENTREZGENE, UniProtKB/TrEMBL
  G3X8V8 ENTREZGENE
  Q3U3Z9 ENTREZGENE
  Q8K2Y2 ENTREZGENE
  Q9QZL0 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary G3X8V8 UniProtKB/Swiss-Prot
  Q3U3Z9 UniProtKB/Swiss-Prot
  Q8K2Y2 UniProtKB/Swiss-Prot