Bmpr1a (bone morphogenetic protein receptor, type 1A) - Rat Genome Database

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Gene: Bmpr1a (bone morphogenetic protein receptor, type 1A) Mus musculus
Symbol: Bmpr1a
Name: bone morphogenetic protein receptor, type 1A
RGD ID: 734373
Description: Enables BMP binding activity and BMP receptor activity. Involved in several processes, including circulatory system development; fibrous ring of heart morphogenesis; and positive regulation of cell population proliferation. Acts upstream of or within several processes, including limb morphogenesis; regionalization; and regulation of gene expression. Located in cell surface. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study Ebstein anomaly; Wolff-Parkinson-White syndrome; and osteoarthritis. Human ortholog(s) of this gene implicated in hereditary mixed polyposis syndrome 2; intestinal disease; and juvenile polyposis syndrome. Orthologous to human BMPR1A (bone morphogenetic protein receptor type 1A).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1110037I22Rik; activin receptor-like kinase 3; AL; ALK-3; ALK3; AU045487; Bm; BMP; BMP type-1A receptor; BMP-2/BMP-4 receptor; Bmpr; BMPR-1A; BMPR-IA; bone morphogenetic protein receptor type-1A; serine/threonine-protein kinase receptor R5; SKR5
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391434,133,018 - 34,225,335 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1434,132,691 - 34,225,298 (-)EnsemblGRCm39 Ensembl
GRCm381434,411,061 - 34,503,336 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1434,410,734 - 34,503,341 (-)EnsemblGRCm38mm10GRCm38
MGSCv371435,224,254 - 35,315,732 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361433,240,160 - 33,331,638 (-)NCBIMGSCv36mm8
Celera1430,676,409 - 30,725,958 (-)NCBICelera
Cytogenetic Map14BNCBI
cM Map1420.81NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
anterior/posterior pattern specification  (IMP)
atrioventricular node cell development  (IMP)
atrioventricular valve development  (IMP)
BMP signaling pathway  (IBA,IDA,IGI,IMP,ISO)
cardiac conduction system development  (IMP)
cardiac right ventricle morphogenesis  (IMP)
cartilage development  (IMP)
cellular response to BMP stimulus  (ISO)
cellular response to growth factor stimulus  (IBA)
central nervous system neuron differentiation  (IGI)
chondrocyte differentiation  (IDA)
developmental growth  (IMP)
dorsal aorta morphogenesis  (IMP)
dorsal/ventral axis specification  (IMP)
dorsal/ventral pattern formation  (IBA,IGI)
ectoderm development  (IMP)
embryonic digit morphogenesis  (IGI)
embryonic morphogenesis  (IMP)
embryonic organ development  (IMP)
endocardial cushion formation  (IMP)
endocardial cushion morphogenesis  (IMP)
endoderm development  (IMP)
epithelial cell proliferation  (IMP)
fibrous ring of heart morphogenesis  (IMP)
heart development  (IMP)
heart formation  (IMP)
heart morphogenesis  (IMP)
hindlimb morphogenesis  (IMP)
immune response  (ISO)
in utero embryonic development  (IMP)
lateral mesoderm development  (IMP)
lung development  (IMP)
mesendoderm development  (IMP)
mesoderm formation  (IMP)
mitral valve morphogenesis  (IMP)
Mullerian duct regression  (IMP)
negative regulation of gene expression  (IMP)
negative regulation of muscle cell differentiation  (IMP)
negative regulation of neurogenesis  (IMP)
negative regulation of smooth muscle cell migration  (ISO)
nervous system development  (IMP)
neural crest cell development  (IMP)
neural plate mediolateral regionalization  (IMP)
neural plate pattern specification  (IMP)
odontogenesis of dentin-containing tooth  (IMP)
osteoblast differentiation  (IDA)
outflow tract morphogenesis  (IMP)
outflow tract septum morphogenesis  (IMP)
paraxial mesoderm development  (IGI,IMP)
paraxial mesoderm structural organization  (IMP)
pattern specification process  (IMP)
pharyngeal arch artery morphogenesis  (IMP)
phosphorylation  (IEA)
pituitary gland development  (IMP)
positive regulation of bone mineralization  (ISO)
positive regulation of cardiac muscle cell proliferation  (IMP)
positive regulation of cardiac ventricle development  (IMP)
positive regulation of epithelial cell proliferation  (IMP)
positive regulation of gene expression  (ISO)
positive regulation of mesenchymal cell proliferation  (IMP)
positive regulation of miRNA transcription  (IDA)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of SMAD protein signal transduction  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IMP,ISO)
positive regulation of transforming growth factor beta2 production  (IMP)
positive regulation of vascular associated smooth muscle cell proliferation  (IMP,ISO)
regulation of cardiac muscle cell apoptotic process  (IMP)
regulation of cardiac muscle cell proliferation  (IMP)
regulation of cellular senescence  (IGI)
regulation of endothelial cell differentiation  (IDA)
regulation of endothelial cell proliferation  (IDA)
regulation of lateral mesodermal cell fate specification  (IGI)
regulation of neural crest cell differentiation  (IMP)
regulation of neural crest cell fate specification  (IMP)
roof of mouth development  (IMP)
somatic stem cell population maintenance  (IMP)
somitogenesis  (IMP)
transforming growth factor beta receptor signaling pathway  (ISO)
transmembrane receptor protein serine/threonine kinase signaling pathway  (IEA)
tricuspid valve morphogenesis  (IMP)
ventricular compact myocardium morphogenesis  (IMP)
ventricular septum morphogenesis  (IMP)
ventricular trabecula myocardium morphogenesis  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal articular cartilage morphology  (IAGP)
abnormal bone structure  (IAGP)
abnormal cardiomyocyte apoptosis  (IAGP)
abnormal cartilage development  (IAGP)
abnormal chondrocyte differentiation  (IAGP)
abnormal chondrocyte morphology  (IAGP)
abnormal digit development  (IAGP)
abnormal digit morphology  (IAGP)
abnormal ear shape  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal embryonic-extraembryonic boundary morphology  (IAGP)
abnormal epiphyseal plate morphology  (IAGP)
abnormal eye development  (IAGP)
abnormal fetal cardiomyocyte proliferation  (IAGP)
abnormal gastric gland morphology  (IAGP)
abnormal hair follicle dermal papilla morphology  (IAGP)
abnormal hair follicle morphology  (IAGP)
abnormal hair follicle orientation  (IAGP)
abnormal hair follicle regression  (IAGP)
abnormal hair growth  (IAGP)
abnormal hair shaft morphology  (IAGP)
abnormal heart morphology  (IAGP)
abnormal hindlimb morphology  (IAGP)
abnormal impulse conducting system conduction  (IAGP)
abnormal long bone epiphysis morphology  (IAGP)
abnormal lung development  (IAGP)
abnormal lung epithelium morphology  (IAGP)
abnormal lung morphology  (IAGP)
abnormal mitral valve cusp morphology  (IAGP)
abnormal mouth morphology  (IAGP)
abnormal nail morphology  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal notochord morphology  (IAGP)
abnormal osteoclast differentiation  (IAGP)
abnormal osteoclast physiology  (IAGP)
abnormal pituitary gland development  (IAGP)
abnormal pyloric gastric gland morphology  (IAGP)
abnormal Rathke's pouch development  (IAGP)
abnormal respiratory system physiology  (IAGP)
abnormal retina ganglion cell morphology  (IAGP)
abnormal retina morphology  (IAGP)
abnormal retina pigment epithelium morphology  (IAGP)
abnormal skeleton development  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal skeleton physiology  (IAGP)
abnormal stomach epithelium morphology  (IAGP)
abnormal submucosal gland morphology  (IAGP)
abnormal suckling behavior  (IAGP)
abnormal synovial joint membrane morphology  (IAGP)
abnormal tail morphology  (IAGP)
abnormal thoracic cage shape  (IAGP)
abnormal tooth development  (IAGP)
abnormal tooth morphology  (IAGP)
abnormal tricuspid valve cusp morphology  (IAGP)
abnormal tricuspid valve morphology  (IAGP)
abnormal ulna morphology  (IAGP)
abnormal vascular branching morphogenesis  (IAGP)
abnormal vascular development  (IAGP)
abnormal vein morphology  (IAGP)
abnormal vertebrae development  (IAGP)
abnormal vertebral column morphology  (IAGP)
abnormal visceral endoderm morphology  (IAGP)
abnormal visceral yolk sac morphology  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
absent atrioventricular cushions  (IAGP)
absent hindlimb  (IAGP)
absent mesoderm  (IAGP)
absent PR interval  (IAGP)
absent teeth  (IAGP)
alopecia  (IAGP)
anophthalmia  (IAGP)
chondrodystrophy  (IAGP)
cyclopia  (IAGP)
decreased body size  (IAGP)
decreased bone ossification  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased cell proliferation  (IAGP)
decreased embryo size  (IAGP)
decreased embryonic epiblast cell proliferation  (IAGP)
decreased fetal size  (IAGP)
decreased grip strength  (IAGP)
decreased joint mobility  (IAGP)
decreased length of long bones  (IAGP)
decreased osteoclast cell number  (IAGP)
decreased radius size  (IAGP)
decreased tumor-free survival time  (IAGP)
decreased type II pneumocyte number  (IAGP)
delayed bone ossification  (IAGP)
Ebstein's malformation of tricuspid valve  (IAGP)
ectopic digits  (IAGP)
embryonic growth arrest  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
enlarged parietal bone  (IAGP)
enophthalmos  (IAGP)
eyelids open at birth  (IAGP)
failure of endochondral bone ossification  (IAGP)
failure of primitive streak formation  (IAGP)
fused joints  (IAGP)
gastric polyps  (IAGP)
hemorrhage  (IAGP)
increased bone mass  (IAGP)
increased bone mineralization  (IAGP)
increased embryonic epiblast cell apoptosis  (IAGP)
increased hair follicle number  (IAGP)
increased retina apoptosis  (IAGP)
increased salivary gland tumor incidence  (IAGP)
increased squamous cell carcinoma incidence  (IAGP)
internal hemorrhage  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
male pseudohermaphroditism  (IAGP)
microcephaly  (IAGP)
midface hypoplasia  (IAGP)
mitral valve regurgitation  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
osteoarthritis  (IAGP)
osteosclerosis  (IAGP)
pale yolk sac  (IAGP)
pallor  (IAGP)
pericardial effusion  (IAGP)
persistent truncus arteriosis  (IAGP)
polydactyly  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
preneoplasia  (IAGP)
preweaning lethality, complete penetrance  (IAGP)
respiratory distress  (IAGP)
secondary sex reversal  (IAGP)
short ears  (IAGP)
short limbs  (IAGP)
short snout  (IAGP)
short tail  (IAGP)
small hair follicles  (IAGP)
small heart  (IAGP)
small thoracic cage  (IAGP)
sparse hair  (IAGP)
stomach inflammation  (IAGP)
syndactyly  (IAGP)
thick embryonic epiblast  (IAGP)
vascular smooth muscle hypoplasia  (IAGP)

References - curated
# Reference Title Reference Citation
1. Mapping of hereditary mixed polyposis syndrome (HMPS) to chromosome 10q23 by genomewide high-density single nucleotide polymorphism (SNP) scan and identification of BMPR1A loss of function. Cao X, etal., J Med Genet. 2006 Mar;43(3):e13.
2. Contiguous gene deletion within chromosome arm 10q is associated with juvenile polyposis of infancy, reflecting cooperation between the BMPR1A and PTEN tumor-suppressor genes. Delnatte C, etal., Am J Hum Genet. 2006 Jun;78(6):1066-74. Epub 2006 Apr 14.
3. Bone morphogenetic protein signalling in heritable versus idiopathic pulmonary hypertension. Dewachter L, etal., Eur Respir J. 2009 Nov;34(5):1100-10. Epub 2009 Mar 26.
4. Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis. Howe JR, etal., Nat Genet. 2001 Jun;28(2):184-7.
5. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
6. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
7. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
8. MGDs mouse GO annotations MGD data from the GO Consortium
10. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
14. Mouse MP Annotation Import Pipeline RGD automated import pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes. Zhou XP, etal., Am J Hum Genet 2001 Oct;69(4):704-11. Epub 2001 Aug 30.
Additional References at PubMed
PMID:1793820   PMID:3268409   PMID:7671812   PMID:7750489   PMID:7798324   PMID:7818535   PMID:7937936   PMID:8065329   PMID:8543149   PMID:8592941   PMID:8605036   PMID:8674409  
PMID:8707881   PMID:8889548   PMID:9207184   PMID:9268344   PMID:9303341   PMID:9547239   PMID:9851982   PMID:9876182   PMID:10349636   PMID:10512203   PMID:10564272   PMID:10631181  
PMID:10749566   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11171689   PMID:11401393   PMID:11511541   PMID:11544199   PMID:11698278   PMID:11701996   PMID:11714671   PMID:11714695  
PMID:11854453   PMID:11857780   PMID:11884477   PMID:12141440   PMID:12351174   PMID:12354394   PMID:12368913   PMID:12399319   PMID:12421925   PMID:12477932   PMID:12520002   PMID:12654290  
PMID:12666204   PMID:12783783   PMID:12805214   PMID:12904583   PMID:12923052   PMID:14574412   PMID:14584896   PMID:14610062   PMID:14610273   PMID:14633973   PMID:14656471   PMID:14681479  
PMID:14701881   PMID:15064755   PMID:15073157   PMID:15084466   PMID:15090551   PMID:15102710   PMID:15124223   PMID:15136139   PMID:15136140   PMID:15239668   PMID:15289457   PMID:15322331  
PMID:15342482   PMID:15342483   PMID:15378062   PMID:15469980   PMID:15489334   PMID:15492776   PMID:15531373   PMID:15556938   PMID:15558476   PMID:15582152   PMID:15673568   PMID:15716346  
PMID:15752764   PMID:15781876   PMID:15840001   PMID:15897891   PMID:15913604   PMID:15963767   PMID:15969004   PMID:16037571   PMID:16049014   PMID:16127465   PMID:16141072   PMID:16141073  
PMID:16314491   PMID:16324690   PMID:16414041   PMID:16432712   PMID:16481421   PMID:16537572   PMID:16556916   PMID:16602821   PMID:16604073   PMID:16622178   PMID:16630606   PMID:16783635  
PMID:16809539   PMID:16887829   PMID:16943278   PMID:16959237   PMID:17065231   PMID:17301089   PMID:17339028   PMID:17359964   PMID:17391983   PMID:17537800   PMID:17553962   PMID:17588538  
PMID:17605791   PMID:17626200   PMID:17678919   PMID:17699604   PMID:17804727   PMID:17823941   PMID:17913790   PMID:17928452   PMID:17967808   PMID:17998461   PMID:18000065   PMID:18079409  
PMID:18087045   PMID:18159948   PMID:18178801   PMID:18233958   PMID:18243104   PMID:18258849   PMID:18272594   PMID:18272846   PMID:18281466   PMID:18287559   PMID:18322278   PMID:18449905  
PMID:18483623   PMID:18498827   PMID:18501628   PMID:18543407   PMID:18579678   PMID:18594511   PMID:18614674   PMID:18667463   PMID:18684091   PMID:18799693   PMID:18927151   PMID:18974875  
PMID:19141668   PMID:19153163   PMID:19211807   PMID:19224984   PMID:19246680   PMID:19272526   PMID:19327734   PMID:19358156   PMID:19369394   PMID:19393343   PMID:19416967   PMID:19442313  
PMID:19592576   PMID:19717734   PMID:19726563   PMID:19733164   PMID:19793887   PMID:19793892   PMID:19804412   PMID:19812316   PMID:19874086   PMID:20043884   PMID:20059955   PMID:20130193  
PMID:20130285   PMID:20211162   PMID:20360068   PMID:20363875   PMID:20392740   PMID:20406889   PMID:20413717   PMID:20417197   PMID:20445055   PMID:20493948   PMID:20522595   PMID:20534673  
PMID:20554972   PMID:20621052   PMID:20663871   PMID:20689554   PMID:20724449   PMID:20730911   PMID:20837004   PMID:20875817   PMID:21034733   PMID:21056086   PMID:21068065   PMID:21068310  
PMID:21084449   PMID:21145505   PMID:21185278   PMID:21194568   PMID:21223962   PMID:21273545   PMID:21303850   PMID:21303853   PMID:21394823   PMID:21415412   PMID:21542012   PMID:21571225  
PMID:21571370   PMID:21613322   PMID:21677750   PMID:21731673   PMID:21763800   PMID:21786321   PMID:21841161   PMID:21848994   PMID:21873635   PMID:21976273   PMID:22036911   PMID:22076636  
PMID:22170575   PMID:22234613   PMID:22306733   PMID:22485132   PMID:22560297   PMID:22698281   PMID:22729085   PMID:22729646   PMID:22761317   PMID:22773757   PMID:22860096   PMID:22872577  
PMID:23077214   PMID:23103586   PMID:23197713   PMID:23250207   PMID:23292934   PMID:23341776   PMID:23360989   PMID:23485971   PMID:23527555   PMID:23560082   PMID:23584254   PMID:23604909  
PMID:23665221   PMID:23676271   PMID:23708139   PMID:23712751   PMID:23736260   PMID:23776616   PMID:23831617   PMID:23891934   PMID:24048844   PMID:24081330   PMID:24098149   PMID:24116187  
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PMID:26148958   PMID:26187948   PMID:26303528   PMID:26407529   PMID:26475222   PMID:26489086   PMID:26496610   PMID:26584636   PMID:26657771   PMID:26683138   PMID:26721398   PMID:26721501  
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PMID:27190064   PMID:27199449   PMID:27209464   PMID:27312334   PMID:27402532   PMID:27609464   PMID:27649478   PMID:27856416   PMID:28059064   PMID:28059714   PMID:28232325   PMID:28346411  
PMID:28445731   PMID:28576771   PMID:28607813   PMID:28641928   PMID:28844842   PMID:28855706   PMID:28922976   PMID:29040444   PMID:29175363   PMID:29229773   PMID:29367466   PMID:29411501  
PMID:29415997   PMID:29440304   PMID:29463648   PMID:29482530   PMID:29483282   PMID:29855498   PMID:29987355   PMID:30021173   PMID:30116001   PMID:30154100   PMID:30154465   PMID:30227271  
PMID:30271947   PMID:30352686   PMID:30446646   PMID:30548566   PMID:30625324   PMID:30692543   PMID:30854720   PMID:31028086   PMID:31036156   PMID:31038803   PMID:31311865   PMID:31586065  
PMID:31619522   PMID:31626379   PMID:31747615   PMID:31758827   PMID:31772009   PMID:31800957   PMID:31869353   PMID:32360900   PMID:32572071   PMID:32603910   PMID:32861780   PMID:32878924  
PMID:33027660   PMID:33184221   PMID:33248111   PMID:33359325   PMID:33372189   PMID:33476325   PMID:33580754   PMID:33658353   PMID:33951440   PMID:33975878   PMID:34031510   PMID:34282140  
PMID:34321999   PMID:35151207   PMID:35235783   PMID:35300973   PMID:35634660   PMID:36094016   PMID:36166408   PMID:36581316   PMID:36910145   PMID:37064883   PMID:37191048   PMID:37385754  
PMID:37607547   PMID:37680190   PMID:37702066  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391434,133,018 - 34,225,335 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1434,132,691 - 34,225,298 (-)EnsemblGRCm39 Ensembl
GRCm381434,411,061 - 34,503,336 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1434,410,734 - 34,503,341 (-)EnsemblGRCm38mm10GRCm38
MGSCv371435,224,254 - 35,315,732 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361433,240,160 - 33,331,638 (-)NCBIMGSCv36mm8
Celera1430,676,409 - 30,725,958 (-)NCBICelera
Cytogenetic Map14BNCBI
cM Map1420.81NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381086,755,763 - 86,932,844 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1086,756,596 - 86,932,825 (+)EnsemblGRCh38hg38GRCh38
GRCh371088,516,376 - 88,687,726 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361088,506,376 - 88,674,925 (+)NCBINCBI36Build 36hg18NCBI36
Build 341088,506,375 - 88,674,924NCBI
Celera1082,519,484 - 82,687,979 (+)NCBICelera
Cytogenetic Map10q23.2NCBI
HuRef1082,370,811 - 82,538,774 (+)NCBIHuRef
CHM1_11088,798,078 - 88,966,382 (+)NCBICHM1_1
T2T-CHM13v2.01087,639,833 - 87,816,596 (+)NCBIT2T-CHM13v2.0
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2169,736,390 - 9,829,825 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,736,630 - 9,780,616 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx169,756,712 - 9,800,677 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01610,901,424 - 10,945,388 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0169,751,786 - 9,795,752 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01610,758,278 - 10,852,170 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1610,758,527 - 10,802,512 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0169,084,569 - 9,127,943 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41610,061,943 - 10,105,854 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11610,061,941 - 10,105,852 (-)NCBI
Celera165,436,477 - 5,480,314 (+)NCBICelera
Cytogenetic Map16p15NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049555105,905,008 - 5,936,312 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555105,812,571 - 5,936,312 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11098,750,184 - 98,925,412 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01083,185,040 - 83,353,239 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11086,742,248 - 86,912,912 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1086,837,469 - 86,912,912 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1434,499,898 - 34,582,481 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl434,517,492 - 34,578,923 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha434,508,865 - 34,570,053 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0434,801,402 - 34,942,941 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl434,769,955 - 34,941,813 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1434,723,326 - 34,784,614 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0434,892,537 - 34,953,583 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0435,397,828 - 35,459,419 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440721343,941,218 - 44,004,913 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493680448,947 - 115,412 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493680452,435 - 115,289 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1487,742,459 - 87,891,790 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11487,743,270 - 87,891,790 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21495,239,745 - 95,280,923 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1944,944,463 - 45,108,832 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl944,941,460 - 45,027,275 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660485,049,884 - 5,217,543 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_004624841219,133 - 265,397 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624841218,642 - 304,744 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Bmpr1a
3533 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1204
Count of miRNA genes:677
Interacting mature miRNAs:807
Transcripts:ENSMUST00000049005, ENSMUST00000165280, ENSMUST00000171343, ENSMUST00000171551
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301991Wta3_mweight adult 3 (mouse)Not determined14388747337887650Mouse
4141550Dbm3_mdiabetes modifier 3 (mouse)Not determined514347339143596Mouse
4141864Mrdq4_mmodifier of retinal degeneration QTL 4 (mouse)Not determined992324548765082Mouse
1300779Dyscalc4_mdystrophic cardiac calcinosis 4 (mouse)Not determined141221287146213007Mouse
27226748Femd8_mfemur midshaft diameter 8, 10 week (mouse)141376927346737457Mouse
27226752Femd4_mfemur midshaft diameter 4, 5 week (mouse)141376927347237457Mouse
1300544Hypn_mhyperinsulinemia (mouse)Not determined141516061649160765Mouse
1301372Sluc13_msusceptibility to lung cancer 13 (mouse)Not determined141882760452827726Mouse
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
14746973Manh76_mmandible shape 76 (mouse)142228721756287217Mouse
4142485Modor2_mmodifier of ocular retardation 2 (mouse)Not determined142492624858179769Mouse
13506929Recrq10_mrecombination rate in male meiosis QTL 10 (mouse)142792195761137449Mouse
10043886Cia49_mcollagen induced arthritis QTL 49 (mouse)Not determined142999699463997133Mouse
27226775Tibl7_mtibia length 7, 5 week (mouse)143032195748837457Mouse
27226744Metcl6_mmetatarsal-calcaneal length 6, 5 week (mouse)143032195752937457Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
1300909Ath13_matherosclerosis 13 (mouse)Not determined143033525064335381Mouse
1300998Cia17_mcollagen induced arthritis 17 (mouse)Not determined143033525064335381Mouse
27226737Metcl12_mmetatarsal-calcaneal length 12, 10 week (mouse)143322195759437449Mouse
14696688Rfq2_mrearing frequency QTL 2, males (mouse)143372195735721957Mouse
27226727Tibl21_mtibia length 21, 16 week (mouse)143412195752937457Mouse

Markers in Region
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381434,413,925 - 34,414,149UniSTSGRCm38
MGSCv371435,227,111 - 35,227,335UniSTSGRCm37
Celera1430,679,266 - 30,679,490UniSTS
Cytogenetic Map14BUniSTS
cM Map1413.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381434,411,437 - 34,412,409UniSTSGRCm38
MGSCv371435,224,623 - 35,225,595UniSTSGRCm37
Celera1430,676,778 - 30,677,750UniSTS
Cytogenetic Map14BUniSTS
cM Map1413.0UniSTS
cM Map1413.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14BUniSTS
cM Map1413.0UniSTS
Whitehead_YAC14 UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381434,418,566 - 34,418,667UniSTSGRCm38
MGSCv371435,231,752 - 35,231,853UniSTSGRCm37
Celera1430,683,978 - 30,684,077UniSTS
Cytogenetic Map14BUniSTS
cM Map1412.5UniSTS
Whitehead Genetic1419.7UniSTS
Whitehead_YAC14 UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381434,413,445 - 34,413,550UniSTSGRCm38
MGSCv371435,226,631 - 35,226,736UniSTSGRCm37
Celera1430,678,786 - 30,678,891UniSTS
Cytogenetic Map14BUniSTS
cM Map1413.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381434,412,037 - 34,412,146UniSTSGRCm38
MGSCv371435,225,223 - 35,225,332UniSTSGRCm37
Celera1430,677,378 - 30,677,487UniSTS
Cytogenetic Map14BUniSTS
cM Map1413.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14BUniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14BUniSTS
cM Map1413.0UniSTS



Nucleotide Sequences
RefSeq Transcripts NM_009758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006518469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006518470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036158412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036158413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide A38817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC125152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC140462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC160930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC166105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK076255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK132051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY365062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC042611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU511310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU840836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D16250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D45002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D45007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D45008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D45012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D45017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D45019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB448233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U04672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z23154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000049005   ⟹   ENSMUSP00000035900
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1434,132,691 - 34,224,644 (-)Ensembl
GRCm38.p6 Ensembl1434,410,734 - 34,502,687 (-)Ensembl
RefSeq Acc Id: ENSMUST00000165280   ⟹   ENSMUSP00000131984
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1434,136,443 - 34,182,513 (-)Ensembl
GRCm38.p6 Ensembl1434,414,486 - 34,460,556 (-)Ensembl
RefSeq Acc Id: ENSMUST00000171343   ⟹   ENSMUSP00000126852
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1434,163,063 - 34,225,298 (-)Ensembl
GRCm38.p6 Ensembl1434,441,106 - 34,503,341 (-)Ensembl
RefSeq Acc Id: ENSMUST00000171551   ⟹   ENSMUSP00000129927
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1434,165,890 - 34,224,485 (-)Ensembl
GRCm38.p6 Ensembl1434,443,933 - 34,502,528 (-)Ensembl
RefSeq Acc Id: NM_009758   ⟹   NP_033888
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm391434,133,025 - 34,224,503 (-)NCBI
GRCm381434,411,068 - 34,502,546 (-)NCBI
MGSCv371435,224,254 - 35,315,732 (-)RGD
Celera1430,676,409 - 30,725,958 (-)RGD
RefSeq Acc Id: XM_006518469   ⟹   XP_006518532
Mouse AssemblyChrPosition (strand)Source
GRCm391434,133,018 - 34,224,667 (-)NCBI
GRCm381434,411,061 - 34,502,649 (-)NCBI
RefSeq Acc Id: XM_006518470   ⟹   XP_006518533
Mouse AssemblyChrPosition (strand)Source
GRCm391434,133,018 - 34,225,335 (-)NCBI
GRCm381434,411,061 - 34,503,336 (-)NCBI
RefSeq Acc Id: XM_036158412   ⟹   XP_036014305
Mouse AssemblyChrPosition (strand)Source
GRCm391434,133,018 - 34,224,436 (-)NCBI
RefSeq Acc Id: XM_036158413   ⟹   XP_036014306
Mouse AssemblyChrPosition (strand)Source
GRCm391434,133,018 - 34,224,436 (-)NCBI
RefSeq Acc Id: NP_033888   ⟸   NM_009758
- Peptide Label: precursor
- UniProtKB: P36895 (UniProtKB/Swiss-Prot),   Q53Z43 (UniProtKB/TrEMBL),   Q60607 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006518533   ⟸   XM_006518470
- Peptide Label: isoform X1
- UniProtKB: P36895 (UniProtKB/Swiss-Prot),   Q53Z43 (UniProtKB/TrEMBL),   Q60607 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006518532   ⟸   XM_006518469
- Peptide Label: isoform X1
- UniProtKB: P36895 (UniProtKB/Swiss-Prot),   Q53Z43 (UniProtKB/TrEMBL),   Q60607 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000035900   ⟸   ENSMUST00000049005
RefSeq Acc Id: ENSMUSP00000129927   ⟸   ENSMUST00000171551
RefSeq Acc Id: ENSMUSP00000126852   ⟸   ENSMUST00000171343
RefSeq Acc Id: ENSMUSP00000131984   ⟸   ENSMUST00000165280
RefSeq Acc Id: XP_036014306   ⟸   XM_036158413
- Peptide Label: isoform X1
- UniProtKB: P36895 (UniProtKB/Swiss-Prot),   Q53Z43 (UniProtKB/TrEMBL),   Q60607 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036014305   ⟸   XM_036158412
- Peptide Label: isoform X1
- UniProtKB: P36895 (UniProtKB/Swiss-Prot),   Q53Z43 (UniProtKB/TrEMBL),   Q60607 (UniProtKB/TrEMBL)
Protein Domains
GS   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P36895-F1-model_v2 AlphaFold P36895 1-532 view protein structure

RGD ID:8681936
Promoter ID:EPDNEW_M18999
Type:initiation region
Description:Mus musculus bone morphogenetic protein receptor, type 1A , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm381434,502,540 - 34,502,600EPDNEW
RGD ID:6824734
Promoter ID:MM_KWN:16213
SO ACC ID:SO:0000170
Tissues & Cell Lines:ES_Cell
Mouse AssemblyChrPosition (strand)Source
MGSCv361435,273,536 - 35,274,327 (-)MPROMDB
RGD ID:6824733
Promoter ID:MM_KWN:16214
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4
Mouse AssemblyChrPosition (strand)Source
MGSCv361435,315,271 - 35,316,602 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1338938 AgrOrtholog
Ensembl Genes ENSMUSG00000021796 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000049005 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000165280.8 UniProtKB/TrEMBL
  ENSMUST00000171343.9 UniProtKB/TrEMBL
  ENSMUST00000171551.2 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Activin_recp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Snake_toxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFB_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12166 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23255 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Activin_recp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
  TGF_beta_GS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bmpr1a PhenoGen
  PS51256 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00467 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57302 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt BMR1A_MOUSE UniProtKB/Swiss-Prot