Cdkn2c (cyclin dependent kinase inhibitor 2C) - Rat Genome Database

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Gene: Cdkn2c (cyclin dependent kinase inhibitor 2C) Mus musculus
Analyze
Symbol: Cdkn2c
Name: cyclin dependent kinase inhibitor 2C
RGD ID: 734347
MGI Page MGI
Description: Enables cyclin-dependent protein serine/threonine kinase inhibitor activity and protein kinase binding activity. Acts upstream of or within negative regulation of stem cell proliferation. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and respiratory system. Used to study breast cancer. Orthologous to human CDKN2C (cyclin dependent kinase inhibitor 2C).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C77269; cyclin-dependent kinase 4 inhibitor C; cyclin-dependent kinase 6 inhibitor; cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4); INK; INK4c; INK4d; p1; p18; p18-INK4c; p18-INK6; p18IN; p18INK4c
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394109,518,073 - 109,523,953 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4109,518,073 - 109,524,386 (-)EnsemblGRCm39 Ensembl
GRCm384109,660,876 - 109,666,756 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4109,660,876 - 109,667,189 (-)EnsemblGRCm38mm10GRCm38
MGSCv374109,333,481 - 109,337,977 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364109,158,808 - 109,163,304 (-)NCBIMGSCv36mm8
Celera4108,000,724 - 108,005,200 (-)NCBICelera
Cytogenetic Map4C7NCBI
cM Map451.32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (ISO)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (EXP)
5-fluorouracil  (ISO)
acetamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (ISO)
amiodarone  (ISO)
amitriptyline  (ISO)
ammonium chloride  (ISO)
apigenin  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
auraptene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
Benzo[ghi]perylene  (EXP)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP)
buspirone  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (EXP)
chloroprene  (EXP)
chlorpromazine  (ISO)
choline  (EXP)
chromium(6+)  (EXP,ISO)
chrysin  (ISO)
cisplatin  (ISO)
clomipramine  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (EXP)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
ethanol  (ISO)
fluoranthene  (EXP)
flutamide  (ISO)
folic acid  (EXP)
genistein  (ISO)
geraniol  (ISO)
GW 4064  (ISO)
imipramine  (ISO)
isoflavones  (ISO)
kaempferol  (ISO)
ketoconazole  (ISO)
L-methionine  (EXP)
lamivudine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
lidocaine  (ISO)
linalool  (ISO)
luteolin  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP)
mono(2-ethylhexyl) phthalate  (EXP)
monobenzyl phthalate  (EXP)
monoethyl phthalate  (EXP)
myricetin  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nimesulide  (ISO)
oxaliplatin  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parathion  (ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP)
SB 431542  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
silver(1+) nitrate  (ISO)
sodium arsenite  (ISO)
Soman  (ISO)
sterigmatocystin  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (ISO)
Tributyltin oxide  (EXP,ISO)
trichloroethene  (ISO)
trimellitic anhydride  (EXP)
Triptolide  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (EXP)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (ISO)
vincristine  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
nucleus  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal apoptosis  (IAGP)
abnormal cell physiology  (IAGP)
abnormal cerebellar molecular layer  (IAGP)
abnormal germ cell morphology  (IAGP)
abnormal Langerhans cell morphology  (IAGP)
abnormal Leydig cell differentiation  (IAGP)
abnormal lymph node medulla morphology  (IAGP)
abnormal lymphocyte morphology  (IAGP)
abnormal male meiosis  (IAGP)
abnormal mammary gland epithelium morphology  (IAGP)
abnormal mammary gland morphology  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal neuronal migration  (IAGP)
abnormal pituitary intermediate lobe morphology  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal T cell physiology  (IAGP)
abnormal testis morphology  (IAGP)
abnormal thymus size  (IAGP)
asthenozoospermia  (IAGP)
ataxia  (IAGP)
cortical renal glomerulopathies  (IAGP)
decreased circulating testosterone level  (IAGP)
decreased germ cell number  (IAGP)
decreased tumor latency  (IAGP)
decreased tumor-free survival time  (IAGP)
dehydration  (IAGP)
dilated rete testis  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged adrenal glands  (IAGP)
enlarged heart  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged pituitary gland  (IAGP)
enlarged spleen  (IAGP)
enlarged testis  (IAGP)
enlarged thymus  (IAGP)
extramedullary hematopoiesis  (IAGP)
increased adenocarcinoma incidence  (IAGP)
increased adrenal gland tumor incidence  (IAGP)
increased B cell derived lymphoma incidence  (IAGP)
increased B cell number  (IAGP)
increased body size  (IAGP)
increased body weight  (IAGP)
increased bone marrow cell number  (IAGP)
increased bronchioalveolar stem cell number  (IAGP)
increased carcinoma incidence  (IAGP)
increased circulating follicle stimulating hormone level  (IAGP)
increased fibroblast proliferation  (IAGP)
increased hemangiosarcoma incidence  (IAGP)
increased Leydig cell number  (IAGP)
increased Leydig cell tumor incidence  (IAGP)
increased lung adenocarcinoma incidence  (IAGP)
increased lung adenoma incidence  (IAGP)
increased lung tumor incidence  (IAGP)
increased lymphoma incidence  (IAGP)
increased mammary adenocarcinoma incidence  (IAGP)
increased mammary gland tumor incidence  (IAGP)
increased medulloblastoma incidence  (IAGP)
increased metastatic potential  (IAGP)
increased pancreas tumor incidence  (IAGP)
increased parathyroid gland tumor incidence  (IAGP)
increased pheochromocytoma incidence  (IAGP)
increased pituitary adenoma incidence  (IAGP)
increased renal carcinoma incidence  (IAGP)
increased sarcoma incidence  (IAGP)
increased spleen white pulp amount  (IAGP)
increased T cell derived lymphoma incidence  (IAGP)
increased T cell number  (IAGP)
increased testis tumor incidence  (IAGP)
increased thyroid tumor incidence  (IAGP)
increased tumor incidence  (IAGP)
kidney cortex cyst  (IAGP)
kidney cyst  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lymph node hyperplasia  (IAGP)
lymphoid hyperplasia  (IAGP)
male infertility  (IAGP)
mammary gland hyperplasia  (IAGP)
oligozoospermia  (IAGP)
pancreas cyst  (IAGP)
pituitary gland hyperplasia  (IAGP)
pituitary intermediate lobe hyperplasia  (IAGP)
seminiferous tubule degeneration  (IAGP)
small testis  (IAGP)
spleen hyperplasia  (IAGP)
testicular atrophy  (IAGP)
thymus hyperplasia  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Haploinsufficiency of p18(INK4c) sensitizes mice to carcinogen-induced tumorigenesis. Bai F, etal., Mol Cell Biol 2003 Feb;23(4):1269-77.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. MGD IEA MGD IEA
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. The Pezcoller lecture: cancer cell cycles revisited. Sherr CJ Cancer Res. 2000 Jul 15;60(14):3689-95.
Additional References at PubMed
PMID:7739547   PMID:8575754   PMID:8889548   PMID:9040936   PMID:9244355   PMID:9372237   PMID:9482902   PMID:9528803   PMID:9744866   PMID:9887329   PMID:9988218   PMID:10349636  
PMID:10498883   PMID:10773440   PMID:10880462   PMID:10913196   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11287627   PMID:11544316   PMID:11606789   PMID:11891212   PMID:12196289  
PMID:12381668   PMID:12477932   PMID:12668976   PMID:14500377   PMID:14500378   PMID:14610273   PMID:14681479   PMID:15107822   PMID:15122268   PMID:15254233   PMID:15475001   PMID:15489334  
PMID:15584024   PMID:15591344   PMID:15730892   PMID:15800025   PMID:15867383   PMID:16141072   PMID:16141073   PMID:16226707   PMID:16234365   PMID:16260494   PMID:16479172   PMID:16602821  
PMID:16625857   PMID:16738322   PMID:16864777   PMID:16919269   PMID:17099725   PMID:17145768   PMID:17177285   PMID:17342741   PMID:17363588   PMID:17409423   PMID:17442339   PMID:17510401  
PMID:17822758   PMID:18316595   PMID:18347090   PMID:18381405   PMID:18625706   PMID:18685787   PMID:19029828   PMID:19076778   PMID:19147535   PMID:19147556   PMID:19196975   PMID:19411068  
PMID:19769959   PMID:19805107   PMID:19854167   PMID:19889636   PMID:20007774   PMID:20059953   PMID:20506362   PMID:20516124   PMID:20671115   PMID:21163929   PMID:21267068   PMID:21543644  
PMID:21677750   PMID:21936707   PMID:22037578   PMID:22154697   PMID:22340591   PMID:22465667   PMID:22504641   PMID:22777348   PMID:22896639   PMID:22958929   PMID:23506836   PMID:23565059  
PMID:24167278   PMID:24220145   PMID:24614758   PMID:24684846   PMID:24687853   PMID:24928431   PMID:24993528   PMID:25150253   PMID:25157181   PMID:25196150   PMID:25239453   PMID:25463925  
PMID:25531316   PMID:25692908   PMID:25784544   PMID:26091048   PMID:26199091   PMID:26292318   PMID:26621269   PMID:26655900   PMID:26766587   PMID:27050100   PMID:27484146   PMID:27588406  
PMID:28287250   PMID:28504719   PMID:28791750   PMID:28923932   PMID:29103956   PMID:29298882   PMID:29334315   PMID:29996906   PMID:30979723   PMID:32325033   PMID:34321999   PMID:34746147  
PMID:34747973   PMID:34851661   PMID:34976209   PMID:37345432  


Genomics

Comparative Map Data
Cdkn2c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394109,518,073 - 109,523,953 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4109,518,073 - 109,524,386 (-)EnsemblGRCm39 Ensembl
GRCm384109,660,876 - 109,666,756 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4109,660,876 - 109,667,189 (-)EnsemblGRCm38mm10GRCm38
MGSCv374109,333,481 - 109,337,977 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364109,158,808 - 109,163,304 (-)NCBIMGSCv36mm8
Celera4108,000,724 - 108,005,200 (-)NCBICelera
Cytogenetic Map4C7NCBI
cM Map451.32NCBI
CDKN2C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38150,960,745 - 50,974,634 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl150,960,745 - 50,974,634 (+)EnsemblGRCh38hg38GRCh38
GRCh37151,434,378 - 51,440,306 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36151,206,955 - 51,212,897 (+)NCBINCBI36Build 36hg18NCBI36
Celera149,720,878 - 49,726,820 (+)NCBICelera
Cytogenetic Map1p32.3NCBI
HuRef149,551,948 - 49,557,890 (+)NCBIHuRef
CHM1_1151,551,919 - 51,557,861 (+)NCBICHM1_1
T2T-CHM13v2.0150,840,624 - 50,854,515 (+)NCBIT2T-CHM13v2.0
Cdkn2c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85129,639,736 - 129,645,564 (-)NCBIGRCr8
mRatBN7.25124,411,123 - 124,416,278 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5124,411,124 - 124,416,278 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5127,025,144 - 127,030,301 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05128,748,224 - 128,753,381 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05128,799,502 - 128,804,659 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05129,347,731 - 129,352,886 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5129,347,732 - 129,352,886 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05133,181,576 - 133,187,391 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45131,012,524 - 131,017,679 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15131,017,750 - 131,022,905 (-)NCBI
Celera5123,151,768 - 123,156,925 (-)NCBICelera
Cytogenetic Map5q35NCBI
Cdkn2c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554648,021,887 - 8,028,241 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554648,022,596 - 8,028,241 (-)NCBIChiLan1.0ChiLan1.0
CDKN2C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21175,890,034 - 175,898,033 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11175,003,649 - 175,036,456 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0150,214,767 - 50,221,465 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1151,704,528 - 51,718,374 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl151,704,528 - 51,718,374 (+)Ensemblpanpan1.1panPan2
CDKN2C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11510,219,974 - 10,224,944 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1510,220,185 - 10,224,390 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1510,371,011 - 10,375,935 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01510,351,609 - 10,356,542 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1510,351,820 - 10,356,034 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11510,156,940 - 10,161,864 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01510,245,354 - 10,250,296 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01510,262,239 - 10,267,163 (-)NCBIUU_Cfam_GSD_1.0
Cdkn2c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505865,640,933 - 65,646,533 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365229,769,756 - 9,775,077 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365229,769,761 - 9,775,374 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDKN2C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6161,160,297 - 161,166,529 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16161,160,290 - 161,166,681 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26148,743,931 - 148,749,851 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDKN2C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12081,964,164 - 81,970,891 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2081,963,562 - 81,968,450 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603335,266,761 - 35,273,493 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdkn2c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248592,091,734 - 2,097,659 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248592,092,622 - 2,097,628 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

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Variants in Cdkn2c
184 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:137
Count of miRNA genes:67
Interacting mature miRNAs:73
Transcripts:ENSMUST00000063531, ENSMUST00000097921
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226782Tibl2_mtibia length 2, 5 week (mouse)490888237111257197Mouse
13824982Svwq1_mseminal vesicle weight QTL 1 (mouse)489888237118857197Mouse
11532714Sluc43_msusceptibility to lung cancer 43 (mouse)446642108123127211Mouse
12904002Opfaq9_mopen field activity QTL 9 (mouse)492975790126975790Mouse
4141623W6q13_mweight 6 weeks QTL 13 (mouse)Not determined88982069140468203Mouse
12910797Pwgrq4_mpre-weaning growth rate QTL 4 (mouse)4105835310141433838Mouse
25314312Syncl2_msynaptonemal complex length 2 (mouse)465718237146584457Mouse
1357726Lnopy1_mlens opacity 1 (mouse)Not determined485428838119429037Mouse
14696687Gdq1_mgrooming duration QTL 1, males (mouse)496888237111857197Mouse
12910794Pwbwq8_mpost-weaning body weight QTL 8 (mouse)4105835310141433838Mouse
14696689Gdq2_mgrooming duration QTL 2, females (mouse)4100857197124893793Mouse
1301382Arvm2_mautoimmune renal vasculitis 2 (mouse)Not determined4107791564141791756Mouse
12910813Pwbwq4_mpre-weaning body weight QTL 4 (mouse)4105835310141433838Mouse
4141093W3q17_mweight 3 weeks QTL 17 (mouse)Not determined88982069140468203Mouse
12910808Pwbwq9_mpost-weaning body weight QTL 9 (mouse)4105835310141433838Mouse
27095939Ulnl9_mulna length 9, 16 week (mouse)465318237118857197Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
12904933Edlmmq3_mextensor digitorum longus muscle mass QTL 3 (mouse)481213991115213991Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined494957579150676858Mouse
1300663Start2_mstartle response 2 (mouse)Not determined4107264957141265153Mouse
1300918Stheal4_msoft tissue heal 4 (mouse)Not determined489969627123969747Mouse
1301556Cd4vts1_mCD4 virgin T cell subset 1 (mouse)Not determined485428838119429037Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined488982069151654550Mouse
1302204Spm1_msplenomegaly modifier (mouse)Not determined482244395116244582Mouse
11039517Ltpr4_mLeishmania tropica response 4 (mouse)479365751113365867Mouse
11039504Ltpr4a_mLeishmania tropica response 4a (mouse)479365751113365867Mouse
11039505Ltpr4c_mLeishmania tropica response 4c (mouse)479365751113365867Mouse
1301930Papg1_mpulmonary adenoma progression 1 (mouse)Not determined485781167119781279Mouse
1301545Gauc_mglucose area under curve (mouse)Not determined476763107110763305Mouse
11039506Ltpr4b_mLeishmania tropica response 4b (mouse)479365751113365867Mouse
13208562Wght7_mweight 7 (mouse)490888237148084457Mouse
1300781Lith8_mlithogenic gene 8 (mouse)Not determined4107264957141265153Mouse
39128212Lwq21_mliver weight QTL 21 (mouse)488982069140468203Mouse
1300689Dob1_mDietary obesity 1 (mouse)Body weight4101574601123127211Mouse
27226716Metcl2_mmetatarsal-calcaneal length 2, 5 week (mouse)488118237118557197Mouse
1301847Fecq2_mfecundity QTL 2 (mouse)Not determined4100071971134072206Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468018237150884457Mouse
1300697Sle2_msystemic lupus erythmatosus susceptibility 2 (mouse)Not determined477957579111957775Mouse
1301597Anxty_manxiety (mouse)Not determined474137574128009280Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse
4141549W10q10_mweight 10 weeks QTL 10 (mouse)Not determined88982069140468203Mouse
1357895Ctrcts_mcataract severity (mouse)Not determined445709925138342753Mouse
1300809Ccrs2_mcorpus callosum hemisphere surface size 2 (mouse)Not determined4107264957141265153Mouse
4142047Mvwf3_mmodifier of von Willebrand factor 3 (mouse)Not determined14010457117072206Mouse
1301106Skts7_mskin tumor susceptibility 7 (mouse)Not determined4100071971134072206Mouse
1301233Sbw2_msplenomegaly-NZB x NZW 2 (mouse)Not determined494957579128009280Mouse
10755520Rbc1_mred blood cell count 1 (mouse)4108477692142477692Mouse
10755521Hct1_mhematocrit 1 (mouse)4108477692142477692Mouse
10755522Hgb1_mhemoglobin 1 (mouse)4108477692142477692Mouse
27095924Pglq2_mpelvic girdle length QTL 2, 5 week (mouse)469118237130727311Mouse
1301118Bbaa23_mB.burgdorferi-associated arthritis 23 (mouse)Not determined485781167119781279Mouse
11532738Abd1_mautoimmune biliary disease 1 (mouse)488982069116271120Mouse
15039368Nmrs19_mNAFLD-associated magnetic resonance shift 19 (mouse)490882780124882780Mouse
27095917Scvln14_msacral vertebrae length 2, 16 week (mouse)468018237130277062Mouse
1301731Cafq2_mcaffeine metabolism QTL 2 (mouse)Not determined494732255128732454Mouse
4141900Skts-fp1_mskin tumor susceptibility in FVB and PWK 1 (mouse)Not determined453550839124055180Mouse
15039382Ltgq7_mliver triglyceride QTL 7 (mouse)4105705794139705794Mouse
15039377Bw45_mbody weight QTL 45 (mouse)4105705794139705794Mouse
12880433Fgf23lq1_mFGF23 serum level QTL 1 (mouse)4101157197135157197Mouse
1300580Lbw2_mlupus NZB x NZW 2 (mouse)Not determined498545539128009280Mouse
15039378Adip30_madiposity 30 (mouse)4105705794139705794Mouse
1301867Idd11_minsulin dependent diabetes susceptibility 11 (mouse)Not determined483604870117605006Mouse
26884449Sklq2_mskull length QTL 2, 5 week (mouse)436700000128993793Mouse
27095905Scvln3_msacral vertebrae length 2, 5 week (mouse)455600000128993793Mouse
1357800Tgq3_mtriglyceride QTL 3 (mouse)Not determined4107055093141055180Mouse
11553870Cmmm_mcarcinoma modifier of MSM (mouse)490590668124590781Mouse

Markers in Region
PMC141153P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384109,664,954 - 109,665,223UniSTSGRCm38
MGSCv374109,337,559 - 109,337,828UniSTSGRCm37
Celera4108,004,782 - 108,005,051UniSTS
Cytogenetic Map4C7UniSTS
cM Map424.7UniSTS
PMC141153P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384109,661,602 - 109,661,952UniSTSGRCm38
MGSCv374109,334,207 - 109,334,557UniSTSGRCm37
Celera4108,001,450 - 108,001,800UniSTS
Cytogenetic Map4C7UniSTS
cM Map424.7UniSTS
RH126134  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384109,660,976 - 109,661,187UniSTSGRCm38
MGSCv374109,333,581 - 109,333,792UniSTSGRCm37
Celera4108,000,824 - 108,001,035UniSTS
Cytogenetic Map4C7UniSTS
cM Map424.7UniSTS
Whitehead/MRC_RH41497.33UniSTS
Cdkn2c  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4C7UniSTS
cM Map424.7UniSTS
D5Lev19  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384109,661,349 - 109,661,531UniSTSGRCm38
MGSCv374109,333,954 - 109,334,136UniSTSGRCm37
Celera4108,001,197 - 108,001,379UniSTS
Cytogenetic Map4C7UniSTS
cM Map424.7UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000063531   ⟹   ENSMUSP00000070313
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4109,518,073 - 109,522,569 (-)Ensembl
GRCm38.p6 Ensembl4109,660,876 - 109,665,372 (-)Ensembl
Ensembl Acc Id: ENSMUST00000097921   ⟹   ENSMUSP00000095534
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4109,518,073 - 109,524,386 (-)Ensembl
GRCm38.p6 Ensembl4109,660,876 - 109,667,189 (-)Ensembl
RefSeq Acc Id: NM_001301368   ⟹   NP_001288297
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394109,518,073 - 109,523,953 (-)NCBI
GRCm384109,660,876 - 109,666,756 (-)NCBI
Celera4108,000,724 - 108,006,584 (-)NCBI
Sequence:
RefSeq Acc Id: NM_007671   ⟹   NP_031697
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394109,518,073 - 109,522,569 (-)NCBI
GRCm384109,660,876 - 109,665,372 (-)NCBI
MGSCv374109,333,481 - 109,337,977 (-)RGD
Celera4108,000,724 - 108,006,584 (-)NCBI
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_031697   ⟸   NM_007671
- UniProtKB: Q60772 (UniProtKB/Swiss-Prot),   Q9D153 (UniProtKB/TrEMBL),   Q3U054 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001288297   ⟸   NM_001301368
- UniProtKB: Q60772 (UniProtKB/Swiss-Prot),   Q9D153 (UniProtKB/TrEMBL),   Q3U054 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000095534   ⟸   ENSMUST00000097921
Ensembl Acc Id: ENSMUSP00000070313   ⟸   ENSMUST00000063531

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q60772-F1-model_v2 AlphaFold Q60772 1-168 view protein structure

Promoters
RGD ID:6835047
Promoter ID:MM_KWN:38980
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_4Hour,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_007671,   OTTMUST00000019256
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364109,337,771 - 109,339,787 (-)MPROMDB
RGD ID:6884172
Promoter ID:EPDNEW_M5537
Type:multiple initiation site
Name:Cdkn2c_1
Description:Mus musculus cyclin-dependent kinase inhibitor 2C (p18, inhibitsCDK4) , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M5538  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384109,665,260 - 109,665,320EPDNEW
RGD ID:6884174
Promoter ID:EPDNEW_M5538
Type:initiation region
Name:Cdkn2c_2
Description:Mus musculus cyclin-dependent kinase inhibitor 2C (p18, inhibitsCDK4) , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M5537  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384109,666,759 - 109,666,819EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:105388 AgrOrtholog
Ensembl Genes ENSMUSG00000028551 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000063531 ENTREZGENE
  ENSMUST00000063531.5 UniProtKB/Swiss-Prot
  ENSMUST00000097921 ENTREZGENE
  ENSMUST00000097921.10 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ank_Repeat/CDKN_Inhibitor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12580 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:105388 ENTREZGENE
NCBI Gene 12580 ENTREZGENE
PANTHER ANK_REP_REGION DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYCLIN-DEPENDENT KINASE 4 INHIBITOR C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ank_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cdkn2c PhenoGen
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ANK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CDN2C_MOUSE UniProtKB/Swiss-Prot
  Q3U054 ENTREZGENE, UniProtKB/TrEMBL
  Q60772 ENTREZGENE
  Q9D153 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-01 Cdkn2c  cyclin dependent kinase inhibitor 2C    cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)  Symbol and/or name change 5135510 APPROVED