Cd86 (CD86 antigen) - Rat Genome Database

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Gene: Cd86 (CD86 antigen) Mus musculus
Analyze
Symbol: Cd86
Name: CD86 antigen
RGD ID: 734336
MGI Page MGI
Description: Predicted to enable receptor ligand activity. Involved in several processes, including positive regulation of immunoglobulin production; positive regulation of non-canonical NF-kappaB signal transduction; and toll-like receptor 3 signaling pathway. Acts upstream of or within several processes, including cellular response to lipopolysaccharide; positive regulation of T cell proliferation; and toll-like receptor signaling pathway. Located in external side of plasma membrane and intracellular membrane-bounded organelle. Is expressed in central nervous system; mandible; and retina. Used to study Guillain-Barre syndrome. Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; autoimmune disease (multiple); chronic lymphocytic leukemia; chronic obstructive pulmonary disease; and systemic scleroderma. Orthologous to human CD86 (CD86 molecule).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: activation B7-2 antigen; B7; B7-2; B7.2; B70; Cd28l; Cd28l2; CLS1; early T cell costimulatory molecule-1; early T-cell costimulatory molecule 1; ETC-1; Gm8528; Ly-5; Ly-58; Ly5; Ly58; MB7; MB7-2; predicted gene 8528; T-lymphocyte activation antigen CD86; TS/A-2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391636,389,318 - 36,486,439 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1636,424,231 - 36,486,443 (-)EnsemblGRCm39 Ensembl
GRCm381636,568,956 - 36,666,158 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1636,603,869 - 36,666,081 (-)EnsemblGRCm38mm10GRCm38
MGSCv371636,603,955 - 36,666,163 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361636,523,113 - 36,585,290 (-)NCBIMGSCv36mm8
Celera1637,019,467 - 37,081,856 (-)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1625.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(R)-lipoic acid  (ISO)
(S)-nicotine  (ISO)
1,10-phenanthroline  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1,3-benzothiazole-2-thiol  (ISO)
1,4-benzoquinone  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-Methoxy-4-methylphenol  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-phenylprop-2-enal  (EXP,ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (EXP)
4-octylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (ISO)
adenosine 5'-[gamma-thio]triphosphate  (EXP)
albendazole  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-hexylcinnamaldehyde  (ISO)
alternariol  (EXP,ISO)
aluminium hydroxide  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
ammonium hexachloroplatinate  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antirheumatic drug  (ISO)
arachidonyl-2'-chloroethylamide  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
asbestos  (ISO)
atorvastatin calcium  (ISO)
Bandrowski's base  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzoyl chloride  (ISO)
benzyl benzoate  (ISO)
benzyl cinnamate  (ISO)
benzylpenicillin  (ISO)
beryllium sulfate  (ISO)
beta-D-glucan  (EXP)
beta-naphthoflavone  (ISO)
betamethasone valerate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (EXP)
calcitriol  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (EXP)
cefaloridine  (ISO)
CGP 52608  (ISO)
chloramine T  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
citral  (ISO)
citric acid  (ISO)
clobetasol  (EXP)
clodronic acid  (EXP)
clopidogrel  (EXP)
cobalt dichloride  (EXP,ISO)
cordycepin  (EXP)
cortisol  (EXP,ISO)
Cyclopamine  (ISO)
daidzein  (EXP)
DDE  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (EXP,ISO)
deoxynivalenol  (EXP)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
dicoumarol  (ISO)
diethyl maleate  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP,ISO)
diiodine  (ISO)
diisononyl phthalate  (EXP)
dimethoate  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (EXP)
diphenylmethane-4,4'-diisocyanate  (ISO)
diuron  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
equol  (EXP)
estriol  (EXP)
ethylene glycol dimethacrylate  (ISO)
ethylmercuric chloride  (ISO)
eugenol  (ISO)
fluorescein 5-isothiocyanate  (ISO)
flutamide  (ISO)
formaldehyde  (ISO)
fulvestrant  (EXP)
furan  (ISO)
genistein  (EXP)
geranial  (ISO)
geraniol  (ISO)
glucuronoxylomannan  (ISO)
glutaraldehyde  (ISO)
glutathione  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
graphite  (ISO)
Harpagide  (EXP)
helenalin  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (EXP,ISO)
hydroxycitronellal  (ISO)
imidurea  (ISO)
imiquimod  (EXP)
immunological adjuvant  (ISO)
indirubin-3'-monoxime  (EXP)
indole-3-methanol  (EXP,ISO)
ionomycin  (EXP,ISO)
kanamycin A  (ISO)
L-cysteine  (ISO)
lead diacetate  (EXP)
lead nitrate  (EXP)
levonorgestrel  (ISO)
lidocaine  (ISO)
linalool  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lupane  (ISO)
manganese(II) chloride  (ISO)
mercury dichloride  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methylarsonic acid  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mifepristone  (ISO)
MK-2206  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monosodium L-glutamate  (EXP)
muramyl dipeptide  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
n-propyl gallate  (ISO)
nandrolone  (ISO)
neomycin  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (ISO)
niclosamide  (EXP)
nicotine  (ISO)
nitric oxide  (ISO)
nonanoic acid  (ISO)
nystatin  (EXP)
ochratoxin A  (ISO)
octanoic acid  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenanthridone  (ISO)
phenethyl caffeate  (ISO)
phenyl benzoate  (ISO)
pirinixic acid  (EXP)
poly(I:C)  (ISO)
polymyxin B2  (EXP,ISO)
potassium dichromate  (ISO)
progesterone  (EXP)
pyridine  (ISO)
pyrithione  (EXP)
quercetin  (EXP)
rac-lactic acid  (ISO)
raloxifene  (EXP)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
S-nitrosoglutathione  (ISO)
SB 203580  (ISO)
SCH 23390  (EXP)
sevoflurane  (EXP)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sirolimus  (EXP)
sodium arsenate  (EXP,ISO)
sodium arsenite  (EXP)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
Soman  (ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sulpiride  (EXP)
tacrolimus hydrate  (ISO)
testosterone  (EXP)
testosterone undecanoate  (ISO)
tetrachloromethane  (EXP)
thimerosal  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
Tributyltin oxide  (EXP)
tributyrin  (EXP)
trimethyltin  (ISO)
Triptolide  (EXP,ISO)
troglitazone  (EXP)
trovafloxacin  (EXP)
ursolic acid  (EXP)
vincristine  (ISO)
vitamin E  (ISO)
Y-27632  (EXP)
zearalenone  (ISO)
zinc dichloride  (EXP)
zinc protoporphyrin  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal action potential  (IAGP)
abnormal CD4-positive, alpha-beta T cell physiology  (IAGP)
abnormal cytokine level  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal dorsal root ganglion morphology  (IAGP)
abnormal dorsal spinal root morphology  (IAGP)
abnormal humoral immune response  (IAGP)
abnormal lymph node B cell domain morphology  (IAGP)
abnormal meninges morphology  (IAGP)
abnormal myelin sheath morphology  (IAGP)
abnormal nerve conduction  (IAGP)
abnormal nervous system morphology  (IAGP)
abnormal spinal cord meninges morphology  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal T cell number  (IAGP)
abnormal T cell physiology  (IAGP)
abnormal T cell proliferation  (IAGP)
abnormal ventral spinal root morphology  (IAGP)
absent spleen germinal center  (IAGP)
brain inflammation  (IAGP)
decreased cell proliferation  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased grip strength  (IAGP)
decreased IgG level  (IAGP)
decreased IgG1 level  (IAGP)
decreased IgG2a level  (IAGP)
decreased interleukin-12 secretion  (IAGP)
decreased interleukin-2 secretion  (IAGP)
decreased nerve conduction velocity  (IAGP)
decreased regulatory T cell number  (IAGP)
decreased susceptibility to autoimmune diabetes  (IAGP)
decreased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
decreased T cell proliferation  (IAGP)
decreased tumor necrosis factor secretion  (IAGP)
demyelination  (IAGP)
hindlimb paralysis  (IAGP)
increased autoantibody level  (IAGP)
increased IgG3 level  (IAGP)
increased IgM level  (IAGP)
increased interferon-gamma secretion  (IAGP)
increased susceptibility to autoimmune diabetes  (IAGP)
increased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
increased T cell proliferation  (IAGP)
increased tumor necrosis factor secretion  (IAGP)
insulitis  (IAGP)
muscular atrophy  (IAGP)
paresis  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Activated microglial cells acquire an immature dendritic cell phenotype and may terminate the immune response in an acute model of EAE. Almolda B, etal., J Neuroimmunol. 2010 Jun;223(1-2):39-54. Epub 2010 May 6.
2. Altered phenotype and function of dendritic cells in children with type 1 diabetes. Angelini F, etal., Clin Exp Immunol. 2005 Nov;142(2):341-6.
3. Small interfering RNA against CD86 during allergen challenge blocks experimental allergic asthma. Asai-Tajiri Y, etal., Respir Res. 2014 Oct 27;15:132. doi: 10.1186/s12931-014-0132-z.
4. A role for dendritic cells in bleomycin-induced pulmonary fibrosis in mice? Bantsimba-Malanda C, etal., Am J Respir Crit Care Med. 2010 Aug 1;182(3):385-95. Epub 2010 Apr 15.
5. Francisella tularensis induces aberrant activation of pulmonary dendritic cells. Bosio CM and Dow SW, J Immunol. 2005 Nov 15;175(10):6792-801.
6. CD86+ or HLA-G+ can be transferred via trogocytosis from myeloma cells to T cells and are associated with poor prognosis. Brown R, etal., Blood. 2012 Sep 6;120(10):2055-63. doi: 10.1182/blood-2012-03-416792. Epub 2012 Jun 15.
7. Studies in B7-deficient mice reveal a critical role for B7 costimulation in both induction and effector phases of experimental autoimmune encephalomyelitis. Chang TT, etal., J Exp Med. 1999 Sep 6;190(5):733-40.
8. Cauterization of central cornea induces recruitment of major histocompatibility complex class II+ Langerhans cells from limbal basal epithelium. Chen W, etal., Cornea. 2010 Jan;29(1):73-9.
9. Anti-tumor immunity in a model of acute myeloid leukemia. Cheuk AT, etal., Leuk Lymphoma. 2009 Mar;50(3):447-54.
10. Increased gene expression of Toll-like receptors and antigen-presenting cell-related molecules in the onset of experimentally induced furcation lesions of endodontic origin in rat molars. Chokechanachaisakul U, etal., J Endod. 2010 Feb;36(2):251-5. Epub 2009 Dec 4.
11. Dexamethasone inhibits immunoreactivity of dendritic cells in patients with chronic idiopathic thrombocytopenic purpura. Chu XX, etal., Blood Coagul Fibrinolysis. 2010 Sep;21(6):564-7. doi: 10.1097/MBC.0b013e32833c2b8c.
12. A functional CD86 polymorphism associated with asthma and related allergic disorders. Corydon TJ, etal., J Med Genet. 2007 Aug;44(8):509-15. Epub 2007 May 18.
13. Low CD86 expression in the nonobese diabetic mouse results in the impairment of both T cell activation and CTLA-4 up-regulation. Dahlen E, etal., J Immunol. 2000 Mar 1;164(5):2444-56.
14. Low expression of antigen-presenting and costimulatory molecules by lung cells from tuberculosis patients. Flores-Batista VC, etal., Braz J Med Biol Res. 2007 Dec;40(12):1671-9. Epub 2007 Oct 29.
15. Lung dendritic cell expression of maturation molecules increases with worsening chronic obstructive pulmonary disease. Freeman CM, etal., Am J Respir Crit Care Med. 2009 Dec 15;180(12):1179-88. Epub 2009 Sep 3.
16. Mature CD11c(+) cells are enhanced in hypersensitivity pneumonitis. Girard M, etal., Eur Respir J. 2009 Sep;34(3):749-56. Epub 2009 Mar 12.
17. Development of human T-cell leukemia virus type 1-transformed tumors in rats following suppression of T-cell immunity by CD80 and CD86 blockade. Hanabuchi S, etal., J Virol. 2000 Jan;74(1):428-35.
18. CD28/B7 costimulation regulates autoimmune diabetes induced with multiple low doses of streptozotocin. Herold KC, etal., J Immunol. 1997 Jan 15;158(2):984-91.
19. Streptococcus pneumoniae Infection aggravates experimental autoimmune encephalomyelitis via Toll-like receptor 2. Herrmann I, etal., Infect Immun. 2006 Aug;74(8):4841-8.
20. Upregulation of B7.2, but not B7.1, on B cells from patients with allergic asthma. Hofer MF, etal., J Allergy Clin Immunol. 1998 Jan;101(1 Pt 1):96-102.
21. House dust mite regulate the lung inflammation of asthmatic mice through TLR4 pathway in airway epithelial cells. Hongjia L, etal., Cell Biochem Funct. 2010 Oct;28(7):597-603.
22. A Lower Proportion of Regulatory B Cells in Patients with Henoch-Schoenlein Purpura Nephritis. Hu X, etal., PLoS One. 2016 Mar 31;11(3):e0152368. doi: 10.1371/journal.pone.0152368. eCollection 2016.
23. AID induces intraclonal diversity and genomic damage in CD86(+) chronic lymphocytic leukemia cells. Huemer M, etal., Eur J Immunol. 2014 Dec;44(12):3747-57. doi: 10.1002/eji.201344421. Epub 2014 Oct 18.
24. Islet-infiltrating t lymphocytes in insulin-dependent diabetic patients express CD80 (B7-1) and CD86 (B7-2). Imagawa A, etal., J Autoimmun. 1996 Jun;9(3):391-6.
25. Distinct transcriptional control in major immunogenetic subsets of chronic lymphocytic leukemia exhibiting subset-biased global DNA methylation profiles. Kanduri M, etal., Epigenetics. 2012 Dec 1;7(12):1435-42. doi: 10.4161/epi.22901. Epub 2012 Nov 15.
26. Artificial dental pulp exposure injury up-regulates antigen-presenting cell-related molecules in rat central nervous system. Kaneko T, etal., J Endod. 2010 Mar;36(3):459-64.
27. Development of murine allergic asthma is dependent upon B7-2 costimulation. Keane-Myers AM, etal., J Immunol. 1998 Jan 15;160(2):1036-43.
28. An essential role for dendritic cells in human and experimental allergic rhinitis. KleinJan A, etal., J Allergy Clin Immunol. 2006 Nov;118(5):1117-25. Epub 2006 Aug 28.
29. CTLA4 and CD86 gene polymorphisms and susceptibility to chronic obstructive pulmonary disease. Liu Y, etal., Hum Immunol. 2010 Nov;71(11):1141-6. Epub 2010 Aug 21.
30. [Expression of co-stimulatory molecules in peripheral blood of patients with idiopathic thrombocytopenic purpura in relation with platelet antibodies]. Ma XR, etal., Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009 Apr;17(2):483-6.
31. Fc gamma receptors regulate immune activation and susceptibility during Mycobacterium tuberculosis infection. Maglione PJ, etal., J Immunol. 2008 Mar 1;180(5):3329-38.
32. Increased expression of costimulatory molecules CD86 and sCTLA-4 in patients with acute lymphoblastic leukemia. Mansour A, etal., Leuk Lymphoma. 2014 Sep;55(9):2120-4. doi: 10.3109/10428194.2013.869328. Epub 2014 Mar 7.
33. MGDs mouse GO annotations MGD data from the GO Consortium
34. Low expression of T-cell co-stimulatory molecules in bone marrow-derived dendritic cells in a mouse model of chronic respiratory infection with Pseudomonas aeruginosa. Mukae H, etal., Tohoku J Exp Med. 2010 Jan;220(1):59-65.
35. A microsphere-based vaccine prevents and reverses new-onset autoimmune diabetes. Phillips B, etal., Diabetes. 2008 Jun;57(6):1544-55. Epub 2008 Mar 3.
36. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
37. B7-1/2 (CD80/CD86) direct signaling to B cells enhances IgG secretion. Rau FC, etal., J Immunol. 2009 Dec 15;183(12):7661-71. Epub .
38. Arming parvoviruses with CpG motifs to improve their oncosuppressive capacity. Raykov Z, etal., Int J Cancer. 2008 Jun 15;122(12):2880-4.
39. Mouse MP Annotation Import Pipeline RGD automated import pipeline
40. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
41. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
42. Functional and phenotypic characteristics of testicular macrophages in experimental autoimmune orchitis. Rival C, etal., J Pathol. 2008 Jun;215(2):108-17.
43. CpG-ODN and MPLA prevent mortality in a murine model of post-hemorrhage-Staphyloccocus aureus pneumonia. Roquilly A, etal., PLoS One. 2010 Oct 7;5(10):e13228.
44. Appearance of cells expressing CD80 and CD86 costimulatory antigens in the pancreas of nonobese diabetic mice. Sainio-Pollanen S, etal., Pancreas. 1996 Nov;13(4):388-94.
45. Enhanced activation of memory, but not naive, B cells in chronic hepatitis C virus-infected patients with cryoglobulinemia and advanced liver fibrosis. Santer DM, etal., PLoS One. 2013 Jun 28;8(6):e68308. doi: 10.1371/journal.pone.0068308. Print 2013.
46. Effects of in vivo administration of anti-B7-1/B7-2 monoclonal antibodies on the survival of mice with chronic ongoing myocarditis caused by Coxsackievirus B3. Seko Y, etal., J Pathol. 1999 May;188(1):107-12. doi: 10.1002/(SICI)1096-9896(199905)188:1<107::AID-PATH319>3.0.CO;2-7.
47. High expression of co-stimulatory and adhesion molecules are observed on eosinophils during human Schistosoma mansoni infection. Silveira-Lemos D, etal., Mem Inst Oswaldo Cruz. 2006 Sep;101 Suppl 1:345-51.
48. Impaired primary immune response in type-1 diabetes. Functional impairment at the level of APCs and T-cells. Spatz M, etal., Cell Immunol. 2003 Jan;221(1):15-26.
49. Boosting airway T-regulatory cells by gastrointestinal stimulation as a strategy for asthma control. Strickland DH, etal., Mucosal Immunol. 2011 Jan;4(1):43-52. Epub 2010 Jul 28.
50. Expression of functional B7-H2 and B7.2 costimulatory molecules and their prognostic implications in de novo acute myeloid leukemia. Tamura H, etal., Clin Cancer Res. 2005 Aug 15;11(16):5708-17.
51. CD86 has sustained costimulatory effects on CD8 T cells. Thomas IJ, etal., J Immunol. 2007 Nov 1;179(9):5936-46.
52. Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke. Thored P, etal., Glia. 2009 Jun;57(8):835-49.
53. CD28-B7-2 but not CD28-B7-1 interaction is required for T cell costimulation in experimental obliterative bronchiolitis in the rat. Tikkanen JM, etal., Transplant Proc. 2001 Feb-Mar;33(1-2):535.
54. Polymorphisms in CD28, CTLA-4, CD80 and CD86 genes may influence the risk of multiple sclerosis and its age of onset. Wagner M, etal., J Neuroimmunol. 2015 Nov 15;288:79-86. doi: 10.1016/j.jneuroim.2015.09.004. Epub 2015 Sep 18.
55. Impairment of monocyte-derived dendritic cells in idiopathic pulmonary arterial hypertension. Wang W, etal., J Clin Immunol. 2009 Nov;29(6):705-13. Epub 2009 Aug 20.
56. In vivo role of dendritic cells in a murine model of pulmonary cryptococcosis. Wozniak KL, etal., Infect Immun. 2006 Jul;74(7):3817-24.
57. B7-2 (CD86) controls the priming of autoreactive CD4 T cell response against pancreatic islets. Yadav D, etal., J Immunol. 2004 Sep 15;173(6):3631-9.
58. Association between high-mobility group box-1 protein release and immune function of dendritic cells in thermal injury. Zhang LT, etal., J Interferon Cytokine Res. 2010 Jul;30(7):487-95.
59. Circulating myeloid dendritic cells are increased in individuals with severe aplastic anemia. Zonghong S, etal., Int J Hematol. 2011 Feb;93(2):156-62. doi: 10.1007/s12185-010-0761-z. Epub 2011 Jan 14.
Additional References at PubMed
PMID:1431091   PMID:2542174   PMID:6411613   PMID:7499829   PMID:7499830   PMID:7504059   PMID:7513726   PMID:7514631   PMID:7515912   PMID:7519245   PMID:7519638   PMID:7525841  
PMID:7531145   PMID:7534198   PMID:7642234   PMID:7720862   PMID:8625983   PMID:8649453   PMID:8683128   PMID:8686742   PMID:8746558   PMID:8943044   PMID:9075931   PMID:9139887  
PMID:9244437   PMID:9250865   PMID:9414288   PMID:9492990   PMID:9548473   PMID:9600957   PMID:9665379   PMID:9690456   PMID:9892625   PMID:10072537   PMID:10201938   PMID:10349636  
PMID:10438978   PMID:10453003   PMID:10490971   PMID:10590107   PMID:10605004   PMID:10623811   PMID:10630300   PMID:10696062   PMID:10725709   PMID:10784605   PMID:10795741   PMID:10820290  
PMID:10878340   PMID:10975864   PMID:11015443   PMID:11029611   PMID:11042159   PMID:11076861   PMID:11120800   PMID:11160311   PMID:11217851   PMID:11285307   PMID:11535635   PMID:11726649  
PMID:11807776   PMID:11826754   PMID:11877291   PMID:11884443   PMID:11929778   PMID:11937530   PMID:11956287   PMID:12055247   PMID:12055251   PMID:12165495   PMID:12207354   PMID:12210763  
PMID:12218093   PMID:12218136   PMID:12244135   PMID:12370335   PMID:12429713   PMID:12444136   PMID:12466851   PMID:12477932   PMID:12516542   PMID:12517941   PMID:12642836   PMID:12682276  
PMID:12734361   PMID:12759417   PMID:12801066   PMID:12835481   PMID:12847135   PMID:14560001   PMID:14610273   PMID:14643301   PMID:14688306   PMID:14724434   PMID:14742503   PMID:14966193  
PMID:15034031   PMID:15096453   PMID:15116295   PMID:15128777   PMID:15197224   PMID:15240714   PMID:15294937   PMID:15314074   PMID:15356139   PMID:15385483   PMID:15467837   PMID:15470046  
PMID:15482852   PMID:15522961   PMID:15528348   PMID:15582152   PMID:15630140   PMID:15634886   PMID:15657954   PMID:15778288   PMID:15780990   PMID:15788440   PMID:15790784   PMID:15808622  
PMID:15843526   PMID:15905503   PMID:15919909   PMID:15944341   PMID:15972645   PMID:15972646   PMID:16002674   PMID:16014035   PMID:16051865   PMID:16078277   PMID:16141072   PMID:16141073  
PMID:16148116   PMID:16200068   PMID:16221763   PMID:16237054   PMID:16237117   PMID:16272276   PMID:16301639   PMID:16424201   PMID:16439314   PMID:16462800   PMID:16476058   PMID:16602821  
PMID:16708399   PMID:16709832   PMID:16724117   PMID:16805995   PMID:16879309   PMID:16886063   PMID:16934307   PMID:16940527   PMID:17109973   PMID:17122127   PMID:17182586   PMID:17237403  
PMID:17277142   PMID:17314080   PMID:17376197   PMID:17429849   PMID:17442938   PMID:17475851   PMID:17513738   PMID:17629367   PMID:17641017   PMID:17699744   PMID:17785819   PMID:17804511  
PMID:17911596   PMID:17982038   PMID:17989345   PMID:18097035   PMID:18178855   PMID:18205792   PMID:18250436   PMID:18279702   PMID:18287559   PMID:18322171   PMID:18328742   PMID:18453575  
PMID:18542049   PMID:18550809   PMID:18606642   PMID:18607347   PMID:18617557   PMID:18628995   PMID:18684917   PMID:18799693   PMID:18802089   PMID:18832683   PMID:18832694   PMID:18848987  
PMID:19047410   PMID:19050296   PMID:19179471   PMID:19188497   PMID:19201420   PMID:19221395   PMID:19234186   PMID:19265158   PMID:19299714   PMID:19326996   PMID:19398542   PMID:19454657  
PMID:19672303   PMID:19710456   PMID:19734906   PMID:19757438   PMID:19770391   PMID:19843945   PMID:19917682   PMID:19917700   PMID:20114085   PMID:20563597   PMID:20574047   PMID:20601595  
PMID:20601598   PMID:20709956   PMID:20724599   PMID:20956339   PMID:20980516   PMID:21040905   PMID:21098219   PMID:21119111   PMID:21126972   PMID:21220452   PMID:21267999   PMID:21277900  
PMID:21357256   PMID:21389258   PMID:21441451   PMID:21474713   PMID:21555535   PMID:21690252   PMID:21697455   PMID:21813777   PMID:21849678   PMID:21849683   PMID:21873635   PMID:21896490  
PMID:21911468   PMID:22199280   PMID:22231652   PMID:22307040   PMID:22312128   PMID:22371880   PMID:22522653   PMID:22544394   PMID:22585421   PMID:22732586   PMID:22733595   PMID:22798683  
PMID:22908331   PMID:23018463   PMID:23108101   PMID:23241883   PMID:23248258   PMID:23248264   PMID:23281398   PMID:23300712   PMID:23335749   PMID:23362346   PMID:23365665   PMID:23377201  
PMID:23439211   PMID:23487421   PMID:23533995   PMID:23584070   PMID:23630352   PMID:23744647   PMID:23793062   PMID:23850635   PMID:23908246   PMID:24099792   PMID:24222350   PMID:24270545  
PMID:24317039   PMID:24337745   PMID:24338929   PMID:24349559   PMID:24470500   PMID:24510964   PMID:24532579   PMID:24610010   PMID:24687086   PMID:24708417   PMID:24771983   PMID:24807557  
PMID:24845056   PMID:24912173   PMID:24981893   PMID:25002484   PMID:25158758   PMID:25548162   PMID:25646266   PMID:25653051   PMID:26263500   PMID:26410627   PMID:26485753   PMID:26952749  
PMID:26979751   PMID:27034402   PMID:27037189   PMID:27075414   PMID:27183612   PMID:27432861   PMID:27569212   PMID:27708164   PMID:27729526   PMID:27732846   PMID:28215575   PMID:28338767  
PMID:28460187   PMID:28767735   PMID:28768709   PMID:28795433   PMID:28919076   PMID:29402722   PMID:29615658   PMID:30010888   PMID:30068595   PMID:30427069   PMID:30468863   PMID:30684382  
PMID:30814730   PMID:30944247   PMID:31010850   PMID:31263704   PMID:31415574   PMID:31448543   PMID:31712675   PMID:32049052   PMID:32572241   PMID:33293517   PMID:33895168   PMID:34788602  
PMID:36450247   PMID:37160118   PMID:38349740   PMID:38596358  


Genomics

Comparative Map Data
Cd86
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391636,389,318 - 36,486,439 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1636,424,231 - 36,486,443 (-)EnsemblGRCm39 Ensembl
GRCm381636,568,956 - 36,666,158 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1636,603,869 - 36,666,081 (-)EnsemblGRCm38mm10GRCm38
MGSCv371636,603,955 - 36,666,163 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361636,523,113 - 36,585,290 (-)NCBIMGSCv36mm8
Celera1637,019,467 - 37,081,856 (-)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1625.72NCBI
CD86
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383122,055,362 - 122,121,136 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3122,055,362 - 122,121,139 (+)EnsemblGRCh38hg38GRCh38
GRCh373121,774,209 - 121,839,983 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363123,256,911 - 123,322,673 (+)NCBINCBI36Build 36hg18NCBI36
Celera3120,183,894 - 120,249,657 (+)NCBICelera
Cytogenetic Map3q13.33NCBI
HuRef3119,148,000 - 119,213,630 (+)NCBIHuRef
CHM1_13121,738,233 - 121,803,970 (+)NCBICHM1_1
T2T-CHM13v2.03124,775,351 - 124,841,114 (+)NCBIT2T-CHM13v2.0
Cd86
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81177,647,565 - 77,706,178 (+)NCBIGRCr8
mRatBN7.21164,142,193 - 64,200,816 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1164,163,828 - 64,200,818 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1172,976,468 - 73,012,708 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01165,638,701 - 65,674,935 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01164,669,718 - 64,705,519 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01167,060,305 - 67,117,990 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1167,082,193 - 67,118,795 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01170,150,748 - 70,208,995 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41166,215,233 - 66,238,882 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11166,272,821 - 66,296,468 (-)NCBI
Celera1163,635,203 - 63,670,914 (+)NCBICelera
Cytogenetic Map11q22NCBI
Cd86
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542721,375,794 - 21,435,874 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542721,375,820 - 21,436,767 (+)NCBIChiLan1.0ChiLan1.0
CD86
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22120,006,752 - 120,072,511 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13120,011,537 - 120,077,290 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03119,151,884 - 119,217,641 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13126,059,008 - 126,124,339 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3126,059,008 - 126,124,339 (+)Ensemblpanpan1.1panPan2
CD86
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13325,256,267 - 25,318,855 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3325,256,267 - 25,318,087 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3325,281,506 - 25,343,086 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03325,491,858 - 25,554,625 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3325,491,761 - 25,553,455 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13325,289,910 - 25,351,816 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03325,332,469 - 25,394,248 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03325,890,298 - 25,952,478 (+)NCBIUU_Cfam_GSD_1.0
Cd86
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602129,038,128 - 129,107,520 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365368,414,491 - 8,481,712 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD86
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13138,427,533 - 138,504,310 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113138,427,573 - 138,504,307 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213148,055,863 - 148,130,754 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CD86
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12258,741,534 - 58,805,417 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2258,741,525 - 58,805,366 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041107,540,631 - 107,604,240 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cd86
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624912350,157 - 426,712 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624912350,201 - 432,410 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cd86
2913 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1059
Count of miRNA genes:587
Interacting mature miRNAs:689
Transcripts:ENSMUST00000089620, ENSMUST00000135280, ENSMUST00000145506, ENSMUST00000154485
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11059560Lmr12b_mleishmaniasis resistance 12b (mouse)162879281362792952Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16841786490896888Mouse
1301841Lrnx9_mlearning-contextual 9 (mouse)Not determined161222536046225471Mouse
1302096Aod1a_mautoimmune ovarian dysgenesis 1a (mouse)Not determined163544664392573008Mouse
4141179Ipng3_mimprinted postnatal growth 3 (mouse)Not determined2277525257594076Mouse
38501069Tip4_mtuberculosis immunophenotype 4, IFN-g level (mouse)16431786444520363Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16381786464620363Mouse
11049571Lmr12c_mleishmaniasis resistance 12c (mouse)162879281362792952Mouse
1301086Lprm5_mlymphoproliferation modifier 5 (mouse)Not determined161184882445848923Mouse
27226768Tibl9_mtibia length 9, 5 week (mouse)16331786451420363Mouse
11059559Lmr12a_mleishmaniasis resistance 12a (mouse)162879281362792952Mouse
1301443Mopkd2_mmodifier of polycystic kidney disease progression 2 (mouse)Not determined16464631438646414Mouse
10043978Obq35_mobesity QTL 35 (mouse)Not determined16988163143881631Mouse
25671380Hrsq2_mhost response to SARS QTL 2, titer (mouse)163140250136540273Mouse
4142187Arrd3_mage-related retinal degeneration 3 (mouse)Not determined3252290965466552Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16654297965466552Mouse
1357517Bwtn1_mbody weight at necropsy 1 (mouse)Not determined162001932985600826Mouse
1300943Skts9_mskin tumor susceptibility 9 (mouse)Not determined16577525239775440Mouse
1301070Cypr1_mcytokine production 1 (mouse)Not determined163231279566312933Mouse
1300915Lmr12_mleishmaniasis resistance 12 (mouse)Not determined162879281362792952Mouse
1300656Bgeq15_mbody growth early QTL 15 (mouse)Not determined16577525239775440Mouse
4142236Pstc4_mperiosteal circumference 4 (mouse)Not determined161552290949523112Mouse
1300534Bmd15_mbone mineral density 15 (mouse)Not determined162193838355938574Mouse
11251724Ewc6_methanol withdrawal and consumption 6 (mouse)16822605242226052Mouse
1300987Skull23_mskull morphology 23 (mouse)Not determined16577525239775440Mouse
1301945Skl7_mskeletal size (tail length) 7 (mouse)Not determined16577525239775440Mouse
10045614Rapop6_mradiation-induced apoptosis 6 (mouse)Not determined161480292148803032Mouse
15092062Egrme4_mearly growth rate, maternal effect 4 (mouse)162521866444220250Mouse
27095908Scvln7_msacral vertebrae length 2, 5 week (mouse)16331786439820362Mouse
10412263Gvhd6_mgraft-versus host disease 6 (mouse)Not determined163606085745511148Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16331786464620363Mouse

Markers in Region
D16Mit11  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381636,633,635 - 36,633,808UniSTSGRCm38
MGSCv371636,633,721 - 36,633,894UniSTSGRCm37
Celera1637,049,377 - 37,049,550UniSTS
Cytogenetic Map16B5UniSTS
cM Map1627.5UniSTS
Whitehead Genetic1625.1UniSTS
Whitehead_YAC16 UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006521741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011245812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004939150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_384517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC117662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF065897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF065898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF065899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF065900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH006741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK079513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY741809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC013807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU284847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L25606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S70108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000089620   ⟹   ENSMUSP00000087047
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1636,424,231 - 36,486,439 (-)Ensembl
GRCm38.p6 Ensembl1636,603,869 - 36,666,077 (-)Ensembl
Ensembl Acc Id: ENSMUST00000135280
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1636,441,075 - 36,463,167 (-)Ensembl
GRCm38.p6 Ensembl1636,620,713 - 36,642,805 (-)Ensembl
Ensembl Acc Id: ENSMUST00000145506
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1636,481,136 - 36,486,443 (-)Ensembl
GRCm38.p6 Ensembl1636,660,774 - 36,666,081 (-)Ensembl
Ensembl Acc Id: ENSMUST00000154485
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1636,424,259 - 36,424,881 (-)Ensembl
GRCm38.p6 Ensembl1636,603,897 - 36,604,519 (-)Ensembl
RefSeq Acc Id: NM_019388   ⟹   NP_062261
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391636,424,231 - 36,486,439 (-)NCBI
GRCm381636,603,869 - 36,666,077 (-)NCBI
MGSCv371636,603,955 - 36,666,163 (-)RGD
Celera1637,019,467 - 37,081,856 (-)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006521741   ⟹   XP_006521804
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391636,424,232 - 36,463,162 (-)NCBI
GRCm381636,603,870 - 36,642,800 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011245812   ⟹   XP_011244114
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391636,424,232 - 36,462,864 (-)NCBI
GRCm381636,603,874 - 36,642,502 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004939150
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391636,389,318 - 36,463,162 (-)NCBI
Sequence:
RefSeq Acc Id: XR_384517
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391636,389,318 - 36,463,162 (-)NCBI
GRCm381636,568,956 - 36,642,800 (-)NCBI
Sequence:
RefSeq Acc Id: NP_062261   ⟸   NM_019388
- Peptide Label: precursor
- UniProtKB: P42082 (UniProtKB/Swiss-Prot),   Q549Q9 (UniProtKB/TrEMBL),   Q3T9F8 (UniProtKB/TrEMBL),   Q3TDR5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006521804   ⟸   XM_006521741
- Peptide Label: isoform X1
- UniProtKB: Q61238 (UniProtKB/TrEMBL),   Q3T9F8 (UniProtKB/TrEMBL),   Q3TDR5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011244114   ⟸   XM_011245812
- Peptide Label: isoform X2
- UniProtKB: Q3T9F8 (UniProtKB/TrEMBL),   Q3TDR5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000087047   ⟸   ENSMUST00000089620
Protein Domains
Ig-like   Ig-like C2-type   Ig-like V-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P42082-F1-model_v2 AlphaFold P42082 1-309 view protein structure

Promoters
RGD ID:6826901
Promoter ID:MM_KWN:20912
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour
Transcripts:OTTMUST00000071002
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361636,604,221 - 36,604,721 (-)MPROMDB
RGD ID:6826902
Promoter ID:MM_KWN:20913
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung
Transcripts:OTTMUST00000070739
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361636,642,671 - 36,643,372 (-)MPROMDB
RGD ID:6826897
Promoter ID:MM_KWN:20914
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:ENSMUST00000023618
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361636,661,206 - 36,661,706 (-)MPROMDB
RGD ID:6826896
Promoter ID:MM_KWN:20915
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Spleen
Transcripts:NM_019388,   OTTMUST00000070738
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361636,665,836 - 36,666,336 (-)MPROMDB
RGD ID:8686130
Promoter ID:EPDNEW_M21096
Type:initiation region
Name:Cd86_1
Description:Mus musculus CD86 antigen , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381636,666,077 - 36,666,137EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:101773 AgrOrtholog
Ensembl Genes ENSMUSG00000022901 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000089620 ENTREZGENE
  ENSMUST00000089620.11 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CD86_IgV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T-cell_Activation_Regulation UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12524 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:101773 ENTREZGENE
NCBI Gene 12524 ENTREZGENE
PANTHER T-LYMPHOCYTE ACTIVATION ANTIGEN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T-LYMPHOCYTE ACTIVATION ANTIGEN CD86 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cd86 PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IGv UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0X9RAD7_MOUSE UniProtKB/TrEMBL
  CD86_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3T9F8 ENTREZGENE, UniProtKB/TrEMBL
  Q3TDR5 ENTREZGENE, UniProtKB/TrEMBL
  Q549Q9 ENTREZGENE, UniProtKB/TrEMBL
  Q61238 ENTREZGENE, UniProtKB/TrEMBL
  Q91YV7_MOUSE UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-05 Cd86  CD86 antigen  Gm8528  predicted gene 8528  Data merged from RGD:1620990 737654 PROVISIONAL