Tgfbr2 (transforming growth factor, beta receptor II) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Tgfbr2 (transforming growth factor, beta receptor II) Mus musculus
Analyze
Symbol: Tgfbr2
Name: transforming growth factor, beta receptor II
RGD ID: 734333
MGI Page MGI
Description: Enables several functions, including SMAD binding activity; transforming growth factor beta binding activity; and transforming growth factor beta receptor activity. Involved in several processes, including circulatory system development; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; and skeletal system development. Acts upstream of or within several processes, including cell surface receptor signaling pathway; positive regulation of tolerance induction; and respiratory system development. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; early conceptus; embryo mesenchyme; genitourinary system; and nervous system. Used to study DiGeorge syndrome; Loeys-Dietz syndrome; cleft soft palate; lung cancer; and prostate cancer. Human ortholog(s) of this gene implicated in several diseases, including Loeys-Dietz syndrome 2; Lynch syndrome (multiple); Marfan syndrome; gastrointestinal system cancer (multiple); and mismatch repair cancer syndrome. Orthologous to human TGFBR2 (transforming growth factor beta receptor 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1110020H15Rik; AU042018; DNIIR; RIIDN; Tbet; Tbeta; TbetaR-II; TbetaRII; TBR; TBR-II; TGF-beta receptor II; TGF-beta receptor type II; TGF-beta receptor type-2; TGF-beta type II receptor; TGFR-2; transforming growth factor-beta receptor type II
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399115,916,763 - 116,004,431 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9115,913,361 - 116,004,428 (-)EnsemblGRCm39 Ensembl
GRCm389116,087,695 - 116,175,363 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9116,084,293 - 116,175,360 (-)EnsemblGRCm38mm10GRCm38
MGSCv379115,996,813 - 116,084,481 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369115,936,405 - 116,023,987 (-)NCBIMGSCv36mm8
Celera9116,548,860 - 116,637,499 (-)NCBICelera
Cytogenetic Map9F3NCBI
cM Map968.39NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
aortic aneurysm  (ISO)
arteriosclerosis  (ISO)
bone disease  (ISO)
Bone Fractures  (ISO)
Bone Neoplasms  (ISO)
Brain Neoplasms  (ISO)
carcinoma  (ISO)
Carotid Artery Injuries  (ISO)
cholangiocarcinoma  (ISO)
cleft soft palate  (IAGP)
colon cancer  (ISO)
Colonic Neoplasms  (ISO)
colorectal cancer  (ISO)
connective tissue disease  (ISO)
Craniofacial Abnormalities  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
DiGeorge syndrome  (IAGP)
Dissecting Aneurysm  (ISO)
Ehlers-Danlos syndrome  (ISO)
esophageal cancer  (ISO)
Esophageal Neoplasms  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Arthritis  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
Eye Abnormalities  (ISO)
Familial Thoracic Aortic Aneurysm 1  (ISO)
Fatigue  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
hepatoblastoma  (ISO)
hepatocellular carcinoma  (ISO)
hereditary nonpolyposis colorectal cancer type 6  (ISO)
Hyperplasia  (ISO)
inguinal hernia  (ISO)
kidney disease  (ISO)
Loeys-Dietz syndrome  (IAGP,ISO)
Loeys-Dietz syndrome 1  (ISO)
Loeys-Dietz syndrome 2  (ISO)
Loeys-Dietz Syndrome, Type 1b  (ISO)
Lung Neoplasms  (ISO)
Lynch syndrome  (ISO)
Marfan syndrome  (ISO)
Marfan Syndrome Type 2  (ISO)
Marfanoid Hypermobility Syndrome  (ISO)
membranoproliferative glomerulonephritis  (ISO)
Microsatellite Instability  (ISO)
migraine  (ISO)
mismatch repair cancer syndrome  (ISO)
multiple acyl-CoA dehydrogenase deficiency  (ISO)
myocardial infarction  (ISO)
Neoplasm Metastasis  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (IMP,ISO)
prostate cancer  (IAGP)
Prostatic Neoplasms  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
Radiation Injuries  (ISO)
Reperfusion Injury  (ISO)
thoracic aortic aneurysm  (ISO)
type 2 diabetes mellitus  (ISO)
vasculogenic impotence  (ISO)
Wolff-Parkinson-White syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
(S)-amphetamine  (EXP)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (EXP)
2-nitrotoluene  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-nitrophenol  (EXP)
4-vinylcyclohexene dioxide  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
8-Br-cAMP  (ISO)
acetaldehyde  (ISO)
acetamide  (ISO)
acteoside  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
aluminium oxide  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
asbestos  (ISO)
avobenzone  (ISO)
azoxystrobin  (ISO)
bellidifolin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (EXP)
bromochloroacetic acid  (ISO)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calciol  (EXP)
calcitriol  (ISO)
Candesartan cilexetil  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chloropicrin  (ISO)
chromium(6+)  (EXP)
cisplatin  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
cyproconazole  (EXP)
D-glucose  (ISO)
deguelin  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
diazepam  (ISO)
diethylstilbestrol  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (EXP)
diuron  (ISO)
doxorubicin  (EXP,ISO)
doxycycline  (EXP)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
folic acid  (EXP,ISO)
FR900359  (ISO)
fructose  (EXP)
furosemide  (ISO)
galangin  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glucose  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (ISO)
hexachlorobenzene  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
inulin  (EXP)
Isoangustone A  (ISO)
isobutanol  (ISO)
isoprenaline  (EXP)
isotretinoin  (ISO)
ketamine  (ISO)
ketoconazole  (ISO)
L-cysteine  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
lithocholic acid  (EXP)
medroxyprogesterone acetate  (ISO)
menadione  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methyl beta-cyclodextrin  (ISO)
methylarsonic acid  (ISO)
Methylazoxymethanol acetate  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N-Vinyl-2-pyrrolidone  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nitrofen  (ISO)
osthole  (ISO)
oxalic acid  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
patulin  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
perindopril  (ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
platycodin D  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
propiconazole  (EXP)
prostaglandin E2  (EXP)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
salvianolic acid B  (ISO)
SB 431542  (EXP)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
streptozocin  (EXP)
succimer  (EXP)
T-2 toxin  (ISO)
tacrolimus hydrate  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
thiram  (ISO)
tipifarnib  (ISO)
tolfenamic acid  (ISO)
toluene 2,4-diisocyanate  (EXP)
torcetrapib  (ISO)
tranilast  (ISO)
trichostatin A  (ISO)
troglitazone  (ISO)
valproic acid  (EXP)
valsartan  (ISO)
vancomycin  (EXP)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (ISO)
animal organ regeneration  (ISO)
aorta morphogenesis  (ISO)
aortic valve morphogenesis  (ISO)
apoptotic process  (ISO)
artery morphogenesis  (ISO)
atrioventricular valve morphogenesis  (IMP)
brain development  (IMP)
branching involved in blood vessel morphogenesis  (IMP)
bronchus development  (IMP)
bronchus morphogenesis  (IMP)
cardiac left ventricle morphogenesis  (IMP)
cartilage development  (IMP)
cell differentiation  (IEA)
cell proliferation involved in endocardial cushion morphogenesis  (IMP)
cell surface receptor protein serine/threonine kinase signaling pathway  (IEA)
cellular response to acetaldehyde  (ISO)
cellular response to growth factor stimulus  (IBA)
digestive tract development  (ISO)
embryo implantation  (ISO)
embryonic cranial skeleton morphogenesis  (IMP)
embryonic hemopoiesis  (IMP)
endocardial cushion fusion  (IMP)
epithelial to mesenchymal transition  (ISO)
gastrulation  (IMP)
growth plate cartilage chondrocyte growth  (IMP)
growth plate cartilage development  (IGI)
heart development  (IBA,IMP)
heart looping  (IMP)
in utero embryonic development  (IMP)
inferior endocardial cushion morphogenesis  (IMP)
Langerhans cell differentiation  (IMP)
lens development in camera-type eye  (IMP)
lens fiber cell apoptotic process  (IDA)
lung development  (IMP,ISO)
lung lobe morphogenesis  (IMP)
lung morphogenesis  (IMP)
mammary gland morphogenesis  (IMP)
membranous septum morphogenesis  (IMP)
miRNA transport  (IMP)
negative regulation of cardiac muscle cell proliferation  (ISO)
negative regulation of cell population proliferation  (ISO)
Notch signaling pathway  (IDA)
outflow tract morphogenesis  (IMP)
outflow tract septum morphogenesis  (IMP)
phosphorylation  (IEA)
positive regulation of angiogenesis  (IGI)
positive regulation of B cell tolerance induction  (IMP)
positive regulation of CD4-positive, alpha-beta T cell proliferation  (ISO)
positive regulation of epithelial cell migration  (IMP)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation  (IMP)
positive regulation of mesenchymal cell proliferation  (IMP)
positive regulation of NK T cell differentiation  (IMP)
positive regulation of reactive oxygen species metabolic process  (ISO)
positive regulation of skeletal muscle tissue regeneration  (ISO)
positive regulation of SMAD protein signal transduction  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of T cell tolerance induction  (IMP)
positive regulation of tolerance induction to self antigen  (IMP)
protein phosphorylation  (IBA,TAS)
receptor-mediated endocytosis  (ISO)
regulation of cell population proliferation  (IMP)
regulation of gene expression  (IMP)
regulation of stem cell differentiation  (ISO)
regulation of stem cell proliferation  (IMP)
response to cholesterol  (IDA,ISO)
response to estrogen  (ISO)
response to glucose  (ISO)
response to hypoxia  (ISO)
response to mechanical stimulus  (ISO)
response to nutrient  (ISO)
response to organic cyclic compound  (ISO)
response to steroid hormone  (ISO)
response to xenobiotic stimulus  (ISO)
roof of mouth development  (ISO)
secondary palate development  (IMP)
SMAD protein signal transduction  (IDA)
smoothened signaling pathway  (IMP)
superior endocardial cushion morphogenesis  (IMP)
trachea formation  (IMP)
trachea morphogenesis  (IMP)
transforming growth factor beta receptor signaling pathway  (IBA,IMP,ISO)
tricuspid valve morphogenesis  (IMP)
vasculogenesis  (IMP,ISO)
ventricular septum morphogenesis  (IMP)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal abdominal lymph node morphology  (IAGP)
abnormal aorta bulb morphology  (IAGP)
abnormal aorta elastic fiber morphology  (IAGP)
abnormal aortic arch and aortic arch branch attachment  (IAGP)
abnormal aortic arch morphology  (IAGP)
abnormal B cell physiology  (IAGP)
abnormal B-1 B cell morphology  (IAGP)
abnormal B-1 B cell number  (IAGP)
abnormal blood vessel physiology  (IAGP)
abnormal brain dura mater morphology  (IAGP)
abnormal branching involved in lung morphogenesis  (IAGP)
abnormal bronchial cartilage morphology  (IAGP)
abnormal bronchus morphology  (IAGP)
abnormal cartilage morphology  (IAGP)
abnormal cholangiocyte morphology  (IAGP)
abnormal coat/hair pigmentation  (IAGP)
abnormal coronary artery morphology  (IAGP)
abnormal craniofacial bone morphology  (IAGP)
abnormal cranium morphology  (IAGP)
abnormal dorsal aorta morphology  (IAGP)
abnormal duodenum morphology  (IAGP)
abnormal electroretinogram waveform feature  (IAGP)
abnormal embryonic hematopoiesis  (IAGP)
abnormal enamel mineralization  (IAGP)
abnormal enamel morphology  (IAGP)
abnormal erythropoiesis  (IAGP)
abnormal fat pad morphology  (IAGP)
abnormal fourth pharyngeal arch artery morphology  (IAGP)
abnormal hair follicle melanocyte morphology  (IAGP)
abnormal hard palate morphology  (IAGP)
abnormal heart morphology  (IAGP)
abnormal hepatic portal vein morphology  (IAGP)
abnormal hepatic portal vein thrombosis  (IAGP)
abnormal hindbrain morphology  (IAGP)
abnormal immune serum protein physiology  (IAGP)
abnormal immune system morphology  (IAGP)
abnormal immune system organ morphology  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal interleukin secretion  (IAGP)
abnormal kidney morphology  (IEA)
abnormal liver morphology  (IEA)
abnormal lung lobe morphology  (IAGP)
abnormal mandible morphology  (IAGP)
abnormal midbrain morphology  (IAGP)
abnormal molar morphology  (IAGP)
abnormal myeloid leukocyte morphology  (IAGP)
abnormal nasal septum morphology  (IAGP)
abnormal neural crest cell morphology  (IAGP)
abnormal neurocranium morphology  (IAGP)
abnormal palatal mesenchymal cell proliferation  (IAGP)
abnormal palatal shelf fusion at midline  (IAGP)
abnormal palatal shelf morphology  (IAGP)
abnormal palate development  (IAGP)
abnormal palate morphology  (IAGP)
abnormal pancreas development  (IAGP)
abnormal parathyroid gland morphology  (IAGP)
abnormal parietal bone morphology  (IAGP)
abnormal pericyte morphology  (IAGP)
abnormal pharyngeal arch morphology  (IAGP)
abnormal primary palate development  (IAGP)
abnormal retina blood vessel morphology  (IAGP)
abnormal retina layer morphology  (IAGP)
abnormal retina morphology  (IAGP)
abnormal retina neuronal layer morphology  (IAGP)
abnormal retina vasculature morphology  (IAGP)
abnormal skeletal muscle fiber morphology  (IAGP)
abnormal soft palate morphology  (IAGP)
abnormal soft palate muscle morphology  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal stationary movement  (IAGP)
abnormal T cell activation  (IAGP)
abnormal tooth attrition  (IAGP)
abnormal tracheal cartilage morphology  (IAGP)
abnormal vasodilation  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
absent frontal bone  (IAGP)
absent gastric milk in neonates  (IAGP)
absent mandibular angle  (IAGP)
absent parathyroid glands  (IAGP)
absent plasma cells  (IAGP)
absent vitelline blood vessels  (IAGP)
aortic dissection  (IAGP)
ascending aorta aneurysm  (IAGP)
autoimmune response  (IAGP)
blood vessel congestion  (IAGP)
centrally nucleated skeletal muscle fibers  (IAGP)
cleft secondary palate  (IAGP)
cleft soft palate  (IAGP)
congestive heart failure  (IAGP)
decreased a-wave amplitude  (IAGP)
decreased b-wave amplitude  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased cranial neural crest cell proliferation  (IAGP)
decreased embryo size  (IAGP)
decreased IgA level  (IAGP)
decreased interleukin-17 secretion  (IAGP)
decreased interleukin-9 secretion  (IAGP)
decreased Langerhans cell number  (IAGP)
decreased regulatory T cell number  (IAGP)
decreased retina ganglion cell number  (IAGP)
decreased tracheal cartilage ring number  (IAGP)
delayed brain development  (IAGP)
delayed heart development  (IAGP)
dilated aorta bulb  (IAGP)
dilated cardiomyopathy  (IAGP)
dilated gallbladder  (IAGP)
dilated respiratory conducting tube  (IAGP)
distended abdomen  (IAGP)
ectopic hair follicle melanin granules  (IAGP)
ectopic melanocytes  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
enlarged heart  (IEA)
enlarged kidney  (IEA)
enlarged pericardium  (IAGP)
enlarged Peyer's patches  (IAGP)
enlarged spleen  (IAGP)
eye inflammation  (IAGP)
hemopericardium  (IAGP)
hemorrhagic ascites  (IAGP)
hemothorax  (IAGP)
hepatic necrosis  (IAGP)
hypoxia  (IAGP)
increased aorta wall thickness  (IAGP)
increased B cell number  (IAGP)
increased fatty acids level  (IAGP)
increased hepatocyte proliferation  (IAGP)
increased IgG level  (IAGP)
increased IgM level  (IAGP)
increased incidence of tumors by chemical induction  (IAGP)
increased inflammatory response  (IAGP)
increased interferon-gamma secretion  (IAGP)
increased interleukin-2 secretion  (IAGP)
increased interleukin-21 secretion  (IAGP)
increased leukocyte cell number  (IAGP)
increased liver weight  (IAGP)
increased lung adenocarcinoma incidence  (IAGP)
increased memory T cell number  (IAGP)
increased metastatic potential  (IAGP)
increased pancreas tumor incidence  (IAGP)
increased pancreatic ductal adenocarcinoma incidence  (IAGP)
increased pancreatic intraepithelial neoplasia incidence  (IAGP)
increased prostate gland adenocarcinoma incidence  (IAGP)
increased prostate intraepithelial neoplasia incidence  (IAGP)
increased regulatory T cell number  (IAGP)
increased retina apoptosis  (IAGP)
increased susceptibility to autoimmune diabetes  (IAGP)
increased T cell number  (IAGP)
increased total body fat amount  (IAGP)
interrupted aortic arch, type b  (IAGP)
jaundice  (IAGP)
kyphosis  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
liver fibrosis  (IAGP)
liver inflammation  (IAGP)
lung inflammation  (IAGP)
microgliosis  (IAGP)
neonatal lethality  (IAGP)
no abnormal phenotype detected  (IAGP)
palatal shelf hypoplasia  (IAGP)
palatal shelves fail to meet at midline  (IAGP)
pale yolk sac  (IAGP)
pancreas inflammation  (IAGP)
paralysis  (IAGP)
parathyroid hypoplasia  (IAGP)
pericardial effusion  (IAGP)
perinatal lethality  (IAGP)
persistence of hyaloid vascular system  (IAGP)
persistent truncus arteriosus  (IAGP)
pigment incontinence  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IAGP)
pulmonary fibrosis  (IAGP)
reduced enamel thickness  (IAGP)
retina detachment  (IAGP)
retina hemorrhage  (IAGP)
retina microaneurysm  (IAGP)
retina neovascularization  (IAGP)
retroesophageal right subclavian artery  (IAGP)
small cranium  (IAGP)
small levator veli palatini muscle  (IAGP)
small liver  (IEA)
small mandible  (IAGP)
small mandibular condyloid process  (IAGP)
small mandibular coronoid process  (IAGP)
small maxilla  (IAGP)
small tensor veli palatini muscle  (IAGP)
small thymus  (IAGP)
stomach inflammation  (IAGP)
thin retina outer nuclear layer  (IAGP)
ventricular septal defect  (IAGP)
vitreous body hemorrhage  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Molecular mechanisms of TGF beta receptor-triggered signaling cascades rapidly induced by the calcineurin inhibitors cyclosporin A and FK506. Akool el-S, etal., J Immunol. 2008 Aug 15;181(4):2831-45.
2. Comparison of expression of TGF-beta1, its receptors TGFbeta1R-I and TGFbeta1R-II in rat kidneys during chronic nephropathy induced by cyclosporine and tacrolimus. Bing P, etal., Transplant Proc. 2006 Sep;38(7):2180-2.
3. Down-modulation of lung immune responses by interleukin-10 and transforming growth factor beta (TGF-beta) and analysis of TGF-beta receptors I and II in active tuberculosis. Bonecini-Almeida MG, etal., Infect Immun. 2004 May;72(5):2628-34.
4. Prognostic significance of transforming growth factor beta receptor II in estrogen receptor-negative breast cancer patients. Buck MB, etal., Clin Cancer Res. 2004 Jan 15;10(2):491-8.
5. Genomic profiling identifies alterations in TGFbeta signaling through loss of TGFbeta receptor expression in human renal cell carcinogenesis and progression. Copland JA, etal., Oncogene. 2003 Sep 11;22(39):8053-62.
6. Bone marrow derived-mesenchymal stem cells downregulate IL17A dependent IL6/STAT3 signaling pathway in CCl4-induced rat liver fibrosis. Farouk S, etal., PLoS One. 2018 Oct 22;13(10):e0206130. doi: 10.1371/journal.pone.0206130. eCollection 2018.
7. Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas. Goggins M, etal., Cancer Res. 1998 Dec 1;58(23):5329-32.
8. Role of transforming growth factor-beta superfamily signaling pathways in human disease. Gordon KJ and Blobe GC, Biochim Biophys Acta. 2008 Apr;1782(4):197-228. Epub 2008 Feb 11.
9. [Detection of the expression of Smad4, transforming growth factor beta(1) and beta receptor II proteins in paraffin-embedded human pancreatic cancer tissues] Gu L, etal., Zhonghua Bing Li Xue Za Zhi. 2001 Dec;30(6):439-42.
10. Elevation of expression of Smads 2, 3, and 4, decorin and TGF-beta in the chronic phase of myocardial infarct scar healing. Hao J, etal., J Mol Cell Cardiol. 1999 Mar;31(3):667-78.
11. Dynamic expression patterns of transforming growth factor-beta(2) and transforming growth factor-beta receptors in experimental glomerulonephritis. Hartner A, etal., J Mol Med. 2003 Jan;81(1):32-42. Epub 2002 Dec 14.
12. Vascular proliferation and transforming growth factor-beta expression in pre- and early stage of diabetes mellitus in Otsuka Long-Evans Tokushima fatty rats. Hosomi N, etal., Atherosclerosis. 2002 May;162(1):69-76.
13. Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression. Ijichi H, etal., Genes Dev. 2006 Nov 15;20(22):3147-60.
14. Mammalian transforming growth factor-betas: Smad signaling and physio-pathological roles. Javelaud D and Mauviel A, Int J Biochem Cell Biol. 2004 Jul;36(7):1161-5.
15. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Jones S, etal., Science. 2008 Sep 26;321(5897):1801-6. Epub 2008 Sep 4.
16. Transforming growth factor-beta 1, 2, 3 and receptor type I and II in diabetic foot ulcers. Jude EB, etal., Diabet Med. 2002 Jun;19(6):440-7.
17. Loss of activin receptor type 2 protein expression in microsatellite unstable colon cancers. Jung B, etal., Gastroenterology. 2004 Mar;126(3):654-9.
18. Effects of anti-TGF-beta type II receptor antibody on experimental glomerulonephritis. Kasuga H, etal., Kidney Int. 2001 Nov;60(5):1745-55.
19. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
20. Differential expression of transforming growth factor-beta type I and II receptors by pulmonary cells in bleomycin-induced lung injury: correlation with repair and fibrosis. Khalil N, etal., Exp Lung Res. 2002 Apr-May;28(3):233-50.
21. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
22. A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2. Loeys BL, etal., Nat Genet. 2005 Mar;37(3):275-81. Epub 2005 Jan 30.
23. In situ detection of TGF betas, TGF beta receptor II mRNA and telomerase activity in rat cholangiocarcinogenesis. Lu JP, etal., World J Gastroenterol 2003 Mar;9(3):590-4.
24. Genomic structure of the transforming growth factor beta type II receptor gene and its mutations in hereditary nonpolyposis colorectal cancers. Lu SL, etal., Cancer Res. 1996 Oct 15;56(20):4595-8.
25. Presence of two signaling TGF-beta receptors in human pancreatic cancer correlates with advanced tumor stage. Lu Z, etal., Dig Dis Sci. 1997 Oct;42(10):2054-63.
26. Frameshift mutational target gene analysis identifies similarities and differences in constitutional mismatch repair-deficiency and Lynch syndrome. Maletzki C, etal., Mol Carcinog. 2017 Jul;56(7):1753-1764. doi: 10.1002/mc.22632. Epub 2017 Mar 30.
27. Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Markowitz S, etal., Science. 1995 Jun 2;268(5215):1336-8.
28. TGFbeta in Cancer. Massagué J, Cell. 2008 Jul 25;134(2):215-30. doi: 10.1016/j.cell.2008.07.001.
29. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
30. MGDs mouse GO annotations MGD data from the GO Consortium
31. MGD IEA MGD IEA
32. Heterozygous TGFBR2 mutations in Marfan syndrome. Mizuguchi T, etal., Nat Genet. 2004 Aug;36(8):855-60. Epub 2004 Jul 4.
33. Dynamic expression of transforming growth factor-betas (TGF-beta) and their type I and type II receptors in the synovial tissue of arthritic rats. Mussener A, etal., Clin Exp Immunol. 1997 Jan;107(1):112-9.
34. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
35. Combination gene therapy of HGF and truncated type II TGF-beta receptor for rat liver cirrhosis after partial hepatectomy. Ozawa S, etal., Surgery. 2006 Apr;139(4):563-73.
36. Mutations in transforming growth factor-beta receptor type II cause familial thoracic aortic aneurysms and dissections. Pannu H, etal., Circulation. 2005 Jul 26;112(4):513-20. Epub 2005 Jul 18.
37. Expressions of transforming growth factor (TGF)-beta1 and TGF-beta type II receptor and their relationship with apoptosis during chemical hepatocarcinogenesis in rats. Park DY, etal., Hepatol Res. 2003 Nov;27(3):205-213.
38. Effect of transforming growth factor beta-1 in endotoxin-induced uveitis. Peng B, etal., Invest Ophthalmol Vis Sci. 1997 Jan;38(1):257-60.
39. Significant expression of endoglin (CD105), TGFbeta-1 and TGFbeta R-2 in the atherosclerotic aorta: an immunohistological study. Piao M and Tokunaga O, J Atheroscler Thromb. 2006 Apr;13(2):82-9.
40. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
41. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
42. Soluble TGFbeta type II receptor gene therapy ameliorates acute radiation-induced pulmonary injury in rats. Rabbani ZN, etal., Int J Radiat Oncol Biol Phys. 2003 Oct 1;57(2):563-72.
43. Mouse MP Annotation Import Pipeline RGD automated import pipeline
44. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
45. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
46. Expression of cavernous transforming growth factor-beta1 and its type II receptor in patients with erectile dysfunction. Ryu JK, etal., Int J Androl. 2004 Feb;27(1):42-9.
47. DNA microarray analysis of pulmonary fibrosis three months after exposure to paraquat in rats. Satomi Y, etal., J Toxicol Sci. 2006 Oct;31(4):345-55.
48. Albumin endocytosis in endothelial cells induces TGF-beta receptor II signaling. Siddiqui SS, etal., Am J Physiol Lung Cell Mol Physiol. 2004 May;286(5):L1016-26. Epub 2004 Jan 16.
49. Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis. Siegel PM, etal., Proc Natl Acad Sci U S A 2003 Jul 8;100(14):8430-5. Epub 2003 Jun 13.
50. Transforming growth factor beta type II receptor expression in gastric cancer: evidence for two independent subgroups. Takeno S, etal., Anticancer Res. 2002 Jul-Aug;22(4):2247-52.
51. A dominant negative mutation of transforming growth factor-beta receptor type II gene in microsatellite stable oesophageal carcinoma. Tanaka S, etal., Br J Cancer. 2000 May;82(9):1557-60.
52. Enhanced expression of the type II transforming growth factor-beta receptor is associated with decreased survival in human pancreatic cancer. Wagner M, etal., Pancreas. 1999 Nov;19(4):370-6.
53. Inhibitory effects of tranilast on expression of transforming growth factor-beta isoforms and receptors in injured arteries. Ward MR, etal., Atherosclerosis. 1998 Apr;137(2):267-75. doi: 10.1016/s0021-9150(97)00275-x.
54. Immunohistochemical expression of FGF-2, PDGF-A, VEGF and TGF beta RII in the pancreas in the course of ischemia/reperfusion-induced acute pancreatitis. Warzecha Z, etal., J Physiol Pharmacol. 2004 Dec;55(4):791-810.
55. A direct interaction between TGFbeta activated kinase 1 and the TGFbeta type II receptor: implications for TGFbeta signalling and cardiac hypertrophy. Watkins SJ, etal., Cardiovasc Res. 2006 Feb 1;69(2):432-9. Epub 2005 Dec 19.
56. Cell-type-specific activation of PAK2 by transforming growth factor beta independent of Smad2 and Smad3. Wilkes MC, etal., Mol Cell Biol. 2003 Dec;23(23):8878-89.
57. Pancreatic cancer: molecular pathogenesis and new therapeutic targets. Wong HH and Lemoine NR, Nat Rev Gastroenterol Hepatol. 2009 Jul;6(7):412-22. Epub 2009 Jun 9.
58. Expression of TGF beta1 genes and their receptor types I, II, and III in low- and high-grade malignancy non-Hodgkin's lymphomas. Woszczyk D, etal., Med Sci Monit. 2004 Jan;10(1):CR33-7.
59. TGF-beta signaling alterations and susceptibility to colorectal cancer. Xu Y and Pasche B, Hum Mol Genet. 2007 Apr 15;16 Spec No 1:R14-20.
60. The TGF-{beta}/Smad2,3 signalling axis is impaired in experimental pulmonary hypertension. Zakrzewicz A, etal., Eur Respir J. 2007 Mar 28;.
Additional References at PubMed
PMID:1319842   PMID:7641785   PMID:7813789   PMID:7957954   PMID:8002998   PMID:8026322   PMID:8117262   PMID:8119124   PMID:8140412   PMID:8268187   PMID:8541216   PMID:8660988  
PMID:8873772   PMID:8883836   PMID:8889548   PMID:8948588   PMID:9010342   PMID:9122204   PMID:9334355   PMID:9449696   PMID:9639680   PMID:9727838   PMID:9856985   PMID:9879710  
PMID:9921650   PMID:10030593   PMID:10198068   PMID:10349636   PMID:10433915   PMID:10446266   PMID:10477295   PMID:10521784   PMID:10588868   PMID:10754527   PMID:10922068   PMID:10951568  
PMID:10960786   PMID:11042159   PMID:11070163   PMID:11076861   PMID:11106407   PMID:11337363   PMID:11559531   PMID:11590434   PMID:11641223   PMID:11675471   PMID:11846446   PMID:11850179  
PMID:11857781   PMID:11893733   PMID:11943186   PMID:12021305   PMID:12070302   PMID:12091349   PMID:12141444   PMID:12466145   PMID:12466851   PMID:12477932   PMID:12588999   PMID:12666204  
PMID:12707256   PMID:12773577   PMID:12773615   PMID:12838410   PMID:12840808   PMID:12975342   PMID:14580334   PMID:14701881   PMID:14764882   PMID:14976186   PMID:14996829   PMID:15073150  
PMID:15158160   PMID:15239668   PMID:15256431   PMID:15322193   PMID:15342483   PMID:15389868   PMID:15459394   PMID:15489334   PMID:15496155   PMID:15496156   PMID:15531369   PMID:15548578  
PMID:15558476   PMID:15562441   PMID:15708853   PMID:15735717   PMID:15741317   PMID:15744664   PMID:15761153   PMID:15781643   PMID:15799023   PMID:15856015   PMID:15965475   PMID:16103213  
PMID:16131565   PMID:16141072   PMID:16141073   PMID:16332365   PMID:16343477   PMID:16368934   PMID:16384533   PMID:16410076   PMID:16598383   PMID:16602821   PMID:16702406   PMID:16780827  
PMID:16806156   PMID:16887142   PMID:16914667   PMID:16948497   PMID:16973386   PMID:16973387   PMID:17047044   PMID:17050629   PMID:17078885   PMID:17168649   PMID:17204263   PMID:17299519  
PMID:17408644   PMID:17418116   PMID:17449229   PMID:17495323   PMID:17543885   PMID:17559664   PMID:17560204   PMID:17576802   PMID:17611229   PMID:17634193   PMID:17638882   PMID:17673906  
PMID:17727833   PMID:17822689   PMID:17823982   PMID:17878231   PMID:17911384   PMID:17936557   PMID:17938236   PMID:18005957   PMID:18029401   PMID:18089935   PMID:18095342   PMID:18098320  
PMID:18167337   PMID:18174260   PMID:18184786   PMID:18240750   PMID:18243111   PMID:18287559   PMID:18321928   PMID:18337748   PMID:18339861   PMID:18385792   PMID:18462697   PMID:18474727  
PMID:18487357   PMID:18498113   PMID:18508041   PMID:18559517   PMID:18563179   PMID:18572160   PMID:18602626   PMID:18648910   PMID:18684439   PMID:18694570   PMID:18724388   PMID:18796535  
PMID:18804439   PMID:18821589   PMID:18945958   PMID:18990706   PMID:19088845   PMID:19165826   PMID:19208363   PMID:19270708   PMID:19304887   PMID:19335617   PMID:19351843   PMID:19361496  
PMID:19369394   PMID:19403103   PMID:19451264   PMID:19463158   PMID:19465598   PMID:19520971   PMID:19556242   PMID:19580641   PMID:19625278   PMID:19653094   PMID:19676134   PMID:19699732  
PMID:19741161   PMID:19757385   PMID:19801644   PMID:19943263   PMID:19959467   PMID:19959810   PMID:20020490   PMID:20054123   PMID:20059955   PMID:20139972   PMID:20144786   PMID:20176743  
PMID:20193675   PMID:20207738   PMID:20213136   PMID:20214815   PMID:20304828   PMID:20346356   PMID:20404343   PMID:20471291   PMID:20471380   PMID:20603020   PMID:20652948   PMID:20660068  
PMID:20709822   PMID:20801928   PMID:20881059   PMID:20886110   PMID:20975697   PMID:21062784   PMID:21135509   PMID:21213115   PMID:21267068   PMID:21282335   PMID:21295274   PMID:21308864  
PMID:21374085   PMID:21376704   PMID:21420963   PMID:21441353   PMID:21518866   PMID:21537080   PMID:21593251   PMID:21593423   PMID:21670270   PMID:21731673   PMID:21873635   PMID:21876535  
PMID:21911454   PMID:21917935   PMID:21926469   PMID:21979435   PMID:22069187   PMID:22087328   PMID:22118468   PMID:22123828   PMID:22190171   PMID:22225602   PMID:22226356   PMID:22279205  
PMID:22290877   PMID:22326956   PMID:22369999   PMID:22371886   PMID:22399565   PMID:22408746   PMID:22496155   PMID:22560297   PMID:22634866   PMID:22685318   PMID:22689996   PMID:22703233  
PMID:22745736   PMID:22753928   PMID:22773728   PMID:22814601   PMID:22863752   PMID:22872153   PMID:22885149   PMID:22901754   PMID:22904682   PMID:22966001   PMID:22972928   PMID:22984076  
PMID:23060211   PMID:23065670   PMID:23103542   PMID:23145171   PMID:23160515   PMID:23227180   PMID:23231014   PMID:23248173   PMID:23290524   PMID:23342175   PMID:23378339   PMID:23406900  
PMID:23408900   PMID:23562608   PMID:23565059   PMID:23569233   PMID:23595735   PMID:23604118   PMID:23610450   PMID:23613893   PMID:23624079   PMID:23661553   PMID:23685840   PMID:23686479  
PMID:23695722   PMID:23712751   PMID:23720048   PMID:23816882   PMID:23856251   PMID:23868260   PMID:23913274   PMID:23929912   PMID:23932572   PMID:23933490   PMID:23946447   PMID:23950180  
PMID:23960190   PMID:23975680   PMID:23982761   PMID:23986258   PMID:23993699   PMID:23995785   PMID:24076049   PMID:24089514   PMID:24115907   PMID:24150221   PMID:24165986   PMID:24278477  
PMID:24282281   PMID:24319055   PMID:24351048   PMID:24355923   PMID:24401272   PMID:24436421   PMID:24449835   PMID:24496627   PMID:24573206   PMID:24586749   PMID:24651496   PMID:24728352  
PMID:24741067   PMID:24760528   PMID:24835278   PMID:24856586   PMID:24898060   PMID:24899714   PMID:24917498   PMID:24946212   PMID:24952961   PMID:24964772   PMID:24983314   PMID:24990151  
PMID:24996922   PMID:25086906   PMID:25108224   PMID:25127858   PMID:25132272   PMID:25138534   PMID:25140527   PMID:25157822   PMID:25233932   PMID:25323858   PMID:25377551   PMID:25382630  
PMID:25406396   PMID:25444235   PMID:25446530   PMID:25450370   PMID:25451249   PMID:25452386   PMID:25456500   PMID:25484855   PMID:25497097   PMID:25505200   PMID:25569154   PMID:25577439  
PMID:25591994   PMID:25680275   PMID:25687406   PMID:25706747   PMID:25722190   PMID:25723170   PMID:25759071   PMID:25760325   PMID:25779936   PMID:25801897   PMID:25818583   PMID:25848047  
PMID:25857227   PMID:25865348   PMID:25924065   PMID:25926361   PMID:26014037   PMID:26032413   PMID:26053644   PMID:26120030   PMID:26151572   PMID:26173585   PMID:26183924   PMID:26202810  
PMID:26216407   PMID:26255562   PMID:26276819   PMID:26279296   PMID:26283373   PMID:26355014   PMID:26407325   PMID:26417101   PMID:26438692   PMID:26494233   PMID:26505114   PMID:26510396  
PMID:26522286   PMID:26526997   PMID:26560028   PMID:26586223   PMID:26587792   PMID:26590320   PMID:26598235   PMID:26627606   PMID:26699479   PMID:26699655   PMID:26792178   PMID:26860770  
PMID:26884601   PMID:26930384   PMID:26988590   PMID:27026702   PMID:27089513   PMID:27141930   PMID:27156386   PMID:27180663   PMID:27224923   PMID:27235139   PMID:27318131   PMID:27329220  
PMID:27362800   PMID:27378170   PMID:27479807   PMID:27481847   PMID:27566402   PMID:27573189   PMID:27599295   PMID:27605619   PMID:27637888   PMID:27667193   PMID:27683557   PMID:27739498  
PMID:27776109   PMID:27777976   PMID:27791005   PMID:27824055   PMID:27835699   PMID:27853171   PMID:27864286   PMID:27866874   PMID:27894066   PMID:27927647   PMID:28009291   PMID:28009292  
PMID:28043895   PMID:28119285   PMID:28143937   PMID:28219480   PMID:28329690   PMID:28368414   PMID:28423340   PMID:28439013   PMID:28518142   PMID:28621313   PMID:28628120   PMID:28662367  
PMID:28701516   PMID:28723546   PMID:28729364   PMID:28734833   PMID:28759001   PMID:28759002   PMID:28775125   PMID:28807903   PMID:28811219   PMID:28823871   PMID:28827353   PMID:28844693  
PMID:28891814   PMID:28924218   PMID:28945200   PMID:28957681   PMID:29031500   PMID:29051340   PMID:29072299   PMID:29091291   PMID:29126797   PMID:29144460   PMID:29186693   PMID:29228234  
PMID:29247325   PMID:29282223   PMID:29337106   PMID:29352019   PMID:29355842   PMID:29364867   PMID:29416028   PMID:29443964   PMID:29449309   PMID:29483576   PMID:29554973   PMID:29575117  
PMID:29662171   PMID:29689292   PMID:29720662   PMID:29753718   PMID:29898959   PMID:29934328   PMID:29945868   PMID:29981310   PMID:30014520   PMID:30156908   PMID:30183689   PMID:30275444  
PMID:30340822   PMID:30385721   PMID:30555301   PMID:30566042   PMID:30592710   PMID:30594464   PMID:30666961   PMID:30745426   PMID:30846482   PMID:30855280   PMID:30940161   PMID:31068441  
PMID:31167144   PMID:31209059   PMID:31289197   PMID:31315051   PMID:31393266   PMID:31398665   PMID:31400222   PMID:31451397   PMID:31455725   PMID:31641222   PMID:31710120   PMID:31770533  
PMID:31801886   PMID:31845891   PMID:31857584   PMID:31949002   PMID:31961320   PMID:32001436   PMID:32243809   PMID:32259484   PMID:32268106   PMID:32290105   PMID:32296307   PMID:32312837  
PMID:32326436   PMID:32369453   PMID:32424365   PMID:32451418   PMID:32470079   PMID:32501213   PMID:32554809   PMID:32581832   PMID:32582853   PMID:32620760   PMID:32745914   PMID:32749453  
PMID:32997394   PMID:33022131   PMID:33027668   PMID:33086036   PMID:33153107   PMID:33175881   PMID:33227706   PMID:33273652   PMID:33615521   PMID:33711270   PMID:33855682   PMID:33881909  
PMID:33927274   PMID:33945787   PMID:34103493   PMID:34129836   PMID:34161267   PMID:34202311   PMID:34211396   PMID:34335618   PMID:34359856   PMID:34452925   PMID:34473197   PMID:34630143  
PMID:34677611   PMID:34975835   PMID:35008801   PMID:35143327   PMID:35166070   PMID:35217866   PMID:35236825   PMID:35269767   PMID:35316682   PMID:35332150   PMID:35344629   PMID:35348629  
PMID:35356426   PMID:35385750   PMID:35439167   PMID:35443795   PMID:35688320   PMID:35894043   PMID:35930670   PMID:35942952   PMID:36045219   PMID:36354355   PMID:36463362   PMID:36521562  
PMID:36580919   PMID:36608150   PMID:36631487   PMID:36762637   PMID:36910145   PMID:36967587   PMID:37024636   PMID:37205636   PMID:37209006   PMID:37220183   PMID:37385754   PMID:37392736  
PMID:37393064   PMID:37625403   PMID:37641131   PMID:37653024   PMID:37702066   PMID:37709007   PMID:37865088   PMID:38157853   PMID:38354086   PMID:38355793   PMID:38645005   PMID:38717426  
PMID:38750036   PMID:38781073   PMID:38871984   PMID:38999956  


Genomics

Comparative Map Data
Tgfbr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399115,916,763 - 116,004,431 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9115,913,361 - 116,004,428 (-)EnsemblGRCm39 Ensembl
GRCm389116,087,695 - 116,175,363 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9116,084,293 - 116,175,360 (-)EnsemblGRCm38mm10GRCm38
MGSCv379115,996,813 - 116,084,481 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369115,936,405 - 116,023,987 (-)NCBIMGSCv36mm8
Celera9116,548,860 - 116,637,499 (-)NCBICelera
Cytogenetic Map9F3NCBI
cM Map968.39NCBI
TGFBR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38330,606,356 - 30,694,142 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl330,606,478 - 30,694,249 (+)EnsemblGRCh38hg38GRCh38
GRCh37330,647,994 - 30,735,634 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36330,622,998 - 30,710,638 (+)NCBINCBI36Build 36hg18NCBI36
Build 34330,623,041 - 30,708,147NCBI
Celera330,584,920 - 30,672,564 (+)NCBICelera
Cytogenetic Map3p24.1NCBI
HuRef330,590,599 - 30,678,240 (+)NCBIHuRef
CHM1_1330,598,177 - 30,685,783 (+)NCBICHM1_1
T2T-CHM13v2.0330,608,862 - 30,696,629 (+)NCBIT2T-CHM13v2.0
Tgfbr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88124,672,677 - 124,761,741 (-)NCBIGRCr8
mRatBN7.28115,794,537 - 115,883,615 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8115,794,537 - 115,883,228 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8121,401,503 - 121,487,689 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08119,600,574 - 119,686,750 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08117,443,698 - 117,530,245 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08124,310,288 - 124,399,345 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8124,312,754 - 124,399,494 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08123,585,765 - 123,671,209 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48120,593,595 - 120,680,453 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18120,613,331 - 120,700,190 (-)NCBI
Celera8115,012,175 - 115,096,500 (-)NCBICelera
Cytogenetic Map8q32NCBI
Tgfbr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543021,932,553 - 22,001,837 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543021,919,338 - 21,999,688 (+)NCBIChiLan1.0ChiLan1.0
TGFBR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2230,595,399 - 30,683,103 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1330,600,475 - 30,687,834 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0330,536,187 - 30,623,653 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1330,854,071 - 30,941,378 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl330,854,460 - 30,938,856 (+)Ensemblpanpan1.1panPan2
TGFBR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12313,886,869 - 13,946,480 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2313,889,000 - 13,977,636 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2313,869,985 - 13,959,686 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02314,182,445 - 14,272,114 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2314,182,447 - 14,272,161 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12313,979,792 - 14,069,422 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02314,125,731 - 14,215,435 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02314,144,194 - 14,234,152 (-)NCBIUU_Cfam_GSD_1.0
Tgfbr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118188,186,107 - 188,270,859 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647321,324,658 - 21,409,430 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647321,324,669 - 21,409,430 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TGFBR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1316,784,490 - 16,878,160 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11316,784,370 - 16,875,828 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21318,707,787 - 18,712,636 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TGFBR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11575,112,903 - 75,200,263 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1575,112,561 - 75,197,711 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604148,399,611 - 48,486,893 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tgfbr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247888,447,542 - 8,535,959 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247888,447,679 - 8,535,821 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tgfbr2
3443 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2190
Count of miRNA genes:582
Interacting mature miRNAs:714
Transcripts:ENSMUST00000035014, ENSMUST00000061101
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982792386116792481Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989440541123440541Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989289476123289595Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986121898120118690Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9101829255124359700Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991560372124359700Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982792386116792481Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989162124123162124Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989859058118767089Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103118511124359700Mouse
14746992Manh67_mmandible shape 67 (mouse)993865836124359700Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982792386116792481Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63239711120191934Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986107600120107729Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963239711120191934Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103118511124359700Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103118511124359700Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993591658124359700Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9100889929124359700Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987677199121677199Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996746658124359700Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991560372124359700Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9101829255124359700Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986625682120625682Mouse
12910773Splic3_mspleen iron content 3 (mouse)991291078124359700Mouse
12910772Lvic6_mliver iron content 6 (mouse)991291078124359700Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991518283124359700Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63239711120191934Mouse
12910770Splic1_mspleen iron content 1 (mouse)991291078124359700Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991560372124359700Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991518283124359700Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991518283124359700Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991518283124359700Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984406017118406120Mouse
13515058Adip20d_madiposity 20d (mouse)9108744078118744078Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991518283124359700Mouse
1301484Bwq6_mbody weight (mouse)Not determined993591658124359700Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991518283124359700Mouse

Markers in Region
Tgfbr2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9F3UniSTS
cM Map969.0UniSTS
cM Map969.0UniSTS
AU042018  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389116,087,912 - 116,088,093UniSTSGRCm38
MGSCv379115,997,030 - 115,997,211UniSTSGRCm37
Celera9116,549,077 - 116,549,258UniSTS
Cytogenetic Map9F3UniSTS
cM Map969.0UniSTS
Whitehead/MRC_RH91147.12UniSTS
UniSTS:236275  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389116,088,017 - 116,088,270UniSTSGRCm38
MGSCv379115,997,135 - 115,997,388UniSTSGRCm37
Celera9116,549,182 - 116,549,435UniSTS
Cytogenetic Map9F3UniSTS
cM Map969.0UniSTS
UniSTS:224191  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389116,137,385 - 116,137,540UniSTSGRCm38
MGSCv379116,046,503 - 116,046,658UniSTSGRCm37
Celera9116,598,652 - 116,598,807UniSTS
Cytogenetic Map9F3UniSTS
cM Map969.0UniSTS
D10Mit157.2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6D1UniSTS
Cytogenetic Map16B4UniSTS
Cytogenetic Map18E2UniSTS
Cytogenetic Map4C3UniSTS
Cytogenetic Map7B2UniSTS
Cytogenetic Map4D2.3UniSTS
Cytogenetic Map11E1UniSTS
Cytogenetic Map14E2.2UniSTS
Cytogenetic Map4C7UniSTS
Cytogenetic Map2H4UniSTS
Cytogenetic Map1FUniSTS
Cytogenetic Map6C3UniSTS
Cytogenetic Map11DUniSTS
Cytogenetic Map3G2UniSTS
Cytogenetic Map17A1UniSTS
Cytogenetic Map9F2UniSTS
Cytogenetic Map12F1UniSTS
Cytogenetic Map19C2UniSTS
Cytogenetic Map3BUniSTS
Cytogenetic Map8C1UniSTS
Cytogenetic Map18A2UniSTS
Cytogenetic Map3F2UniSTS
Cytogenetic Map14C3UniSTS
Cytogenetic Map8E1UniSTS
Cytogenetic Map8E2UniSTS
Cytogenetic Map5B1UniSTS
Cytogenetic Map18B1UniSTS
Cytogenetic Map9CUniSTS
Cytogenetic Map14C2UniSTS
Cytogenetic Map6A1UniSTS
Cytogenetic Map10B4UniSTS
Cytogenetic Map13D2.1UniSTS
Cytogenetic Map5E5UniSTS
Cytogenetic Map11B1.3UniSTS
Cytogenetic Map4D1UniSTS
Cytogenetic Map9A5.2UniSTS
Cytogenetic Map3F1UniSTS
Cytogenetic Map17E3UniSTS
Cytogenetic Map11B3UniSTS
Cytogenetic Map1H4UniSTS
Cytogenetic Map6A3UniSTS
Cytogenetic Map5E4-E5UniSTS
Cytogenetic Map15E1UniSTS
Cytogenetic Map13DUniSTS
Cytogenetic Map14BUniSTS
Cytogenetic Map14D1UniSTS
Cytogenetic Map7B4UniSTS
Cytogenetic Map8D3UniSTS
Cytogenetic MapXDUniSTS
Cytogenetic Map17A3.3UniSTS
Cytogenetic Map7E2UniSTS
Cytogenetic Map1H2.3UniSTS
Cytogenetic Map7A2UniSTS
Cytogenetic Map7F3UniSTS
Cytogenetic Map9F1UniSTS
Cytogenetic Map10C1UniSTS
Cytogenetic Map4E2UniSTS
Cytogenetic Map16A1UniSTS
Cytogenetic Map8B3.3UniSTS
Cytogenetic Map8D2UniSTS
Cytogenetic Map3DUniSTS
Cytogenetic Map15D2UniSTS
Cytogenetic Map17B1UniSTS
Cytogenetic Map7A3UniSTS
Cytogenetic Map15F1UniSTS
Cytogenetic Map16B2UniSTS
Cytogenetic Map7CUniSTS
Cytogenetic Map3F2.1UniSTS
Cytogenetic Map6F3UniSTS
Cytogenetic Map1C4UniSTS
Cytogenetic Map11E2UniSTS
Cytogenetic Map11B5UniSTS
Cytogenetic Map9F3UniSTS
Cytogenetic Map2BUniSTS
Cytogenetic Map13B3UniSTS
Cytogenetic Map9A4UniSTS
Cytogenetic Map5A3UniSTS
Cytogenetic Map2H1UniSTS
Cytogenetic Map16B1UniSTS
Cytogenetic Map1A5UniSTS
Cytogenetic Map11CUniSTS
Cytogenetic Map9E1UniSTS
Cytogenetic Map6G1UniSTS
Cytogenetic MapXA2UniSTS
Cytogenetic Map13B1UniSTS
Cytogenetic Map5E2UniSTS
Cytogenetic Map12C1UniSTS
Cytogenetic Map5FUniSTS
Cytogenetic Map4D3UniSTS
Cytogenetic Map10C2UniSTS
Cytogenetic Map9BUniSTS
Cytogenetic Map5G2UniSTS
Cytogenetic Map7F1UniSTS
Cytogenetic Map12C3UniSTS
Cytogenetic Map10A4UniSTS
Cytogenetic Map8A2UniSTS
Cytogenetic Map18A1UniSTS
Cytogenetic Map12A1.1UniSTS
Cytogenetic Map1C2UniSTS
Cytogenetic Map11B2UniSTS
Cytogenetic Map6E3UniSTS
Cytogenetic Map5C3.3UniSTS
Cytogenetic Map1BUniSTS
Cytogenetic Map17A3.1UniSTS
Cytogenetic Map7A1UniSTS
Cytogenetic Map2E5UniSTS
Cytogenetic Map11A1UniSTS
Cytogenetic Map4B1UniSTS
Cytogenetic Map15A2UniSTS
Cytogenetic Map8C3UniSTS
Cytogenetic Map2A3UniSTS
Cytogenetic Map5G3UniSTS
Cytogenetic Map4A3UniSTS
Cytogenetic Map2H3UniSTS
Cytogenetic Map8A1UniSTS
Cytogenetic Map8A1.1UniSTS
Cytogenetic Map16A3UniSTS
Cytogenetic Map10B1UniSTS
Cytogenetic Map19AUniSTS
Cytogenetic Map10A1UniSTS
Cytogenetic Map13D1UniSTS
Cytogenetic Map4A1UniSTS
Cytogenetic Map9A3UniSTS
Cytogenetic Map17CUniSTS
Cytogenetic Map1DUniSTS
Cytogenetic Map5E3UniSTS
Cytogenetic Map15D3UniSTS
Cytogenetic Map2H2UniSTS
Cytogenetic Map7D3UniSTS
Cytogenetic Map2A1UniSTS
Cytogenetic Map14C1UniSTS
Cytogenetic Map14E5UniSTS
Cytogenetic Map10CUniSTS
Cytogenetic Map18B2UniSTS
Cytogenetic Map2F1UniSTS
Cytogenetic Map10D3UniSTS
Cytogenetic Map17A2UniSTS
Cytogenetic Map2C3UniSTS
Cytogenetic Map1C3UniSTS
Cytogenetic Map17B2UniSTS
Cytogenetic Map5B2UniSTS
Cytogenetic Map5G1UniSTS
Cytogenetic Map4C6UniSTS
Cytogenetic Map13C3UniSTS
Cytogenetic Map2E1UniSTS
Cytogenetic Map17A3.2-A3.3UniSTS
Cytogenetic Map19C3UniSTS
Cytogenetic Map7E3UniSTS
Cytogenetic Map13C1UniSTS
Cytogenetic Map9E3.1UniSTS
Cytogenetic Map15E3UniSTS
Cytogenetic Map6B1UniSTS
Cytogenetic MapXE3UniSTS
Cytogenetic Map4C4UniSTS
Cytogenetic Map3E3UniSTS
Cytogenetic Map11A4UniSTS
Cytogenetic Map4C5UniSTS
Cytogenetic Map18B3UniSTS
Cytogenetic Map9A2UniSTS
Cytogenetic Map7E1UniSTS
Cytogenetic Map5D-E1UniSTS
Cytogenetic Map5B3UniSTS
Cytogenetic Map13A2-A3UniSTS
Cytogenetic Map5A2UniSTS
Cytogenetic Map4B3UniSTS
Cytogenetic Map1E4UniSTS
Cytogenetic Map17E4UniSTS
Cytogenetic Map1G2UniSTS
Cytogenetic Map15B3.1UniSTS
Cytogenetic Map12EUniSTS
Cytogenetic MapXA5UniSTS
Cytogenetic Map6A3.3UniSTS
Cytogenetic Map6G3UniSTS
Cytogenetic Map6F2UniSTS
Cytogenetic Map5C1UniSTS
Cytogenetic Map4D2.1UniSTS
Cytogenetic Map4A5UniSTS
Cytogenetic Map3F2.2UniSTS
Cytogenetic Map1E3-E4UniSTS
Cytogenetic Map9F1-F3UniSTS
Cytogenetic Map1C1.1UniSTS
Cytogenetic Map14D2UniSTS
Cytogenetic Map12A2UniSTS
Cytogenetic Map17A3-BUniSTS
Cytogenetic Map7F5UniSTS
Cytogenetic Map14A3UniSTS
Cytogenetic Map5G1.1UniSTS
Cytogenetic MapXF2-F4UniSTS
Cytogenetic Map7D2UniSTS
Cytogenetic Map2F3UniSTS
Cytogenetic Map10A3UniSTS
Cytogenetic MapXA7.3UniSTS
Cytogenetic Map9F1-F2UniSTS
Cytogenetic Map13A3.2UniSTS
Cytogenetic Map10A2UniSTS
Cytogenetic Map1C1UniSTS
Cytogenetic Map1A1UniSTS
Cytogenetic Map12D3UniSTS
Cytogenetic Map1A3-A5UniSTS
Cytogenetic Map2A2UniSTS
Cytogenetic Map3A1UniSTS
Cytogenetic MapXA3.3UniSTS
Cytogenetic Map16A-B1UniSTS
Cytogenetic Map1D2.3UniSTS
Cytogenetic Map6B2.3UniSTS
Cytogenetic Map2G3UniSTS
Cytogenetic MapXA2-A3.1UniSTS
Cytogenetic Map9A5.3UniSTS
Cytogenetic Map14A2-BUniSTS
Cytogenetic Map8E1-E2UniSTS
Cytogenetic Map8A3UniSTS
Cytogenetic Map1G3-H1UniSTS
Cytogenetic Map8B3-C1UniSTS
Cytogenetic Map19C1UniSTS
Cytogenetic Map8C5UniSTS
Cytogenetic Map8A4UniSTS
Cytogenetic Map15F3UniSTS
Cytogenetic Map14E4UniSTS
Cytogenetic Map4D2.2UniSTS
Cytogenetic MapXF5UniSTS
cM Map1040.0UniSTS
Whitehead Genetic1033.9UniSTS
Tgfbr2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9F3UniSTS
Tgfbr2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9F3UniSTS
cM Map969.0UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_009371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_029575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC131777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF118264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF406755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK003861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK043619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK046561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK053793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK090393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC016262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC052629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO039384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S69114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000035014   ⟹   ENSMUSP00000035014
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9115,917,997 - 116,004,428 (-)Ensembl
GRCm38.p6 Ensembl9116,088,929 - 116,175,360 (-)Ensembl
Ensembl Acc Id: ENSMUST00000061101   ⟹   ENSMUSP00000062333
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9115,913,361 - 116,004,333 (-)Ensembl
GRCm38.p6 Ensembl9116,084,293 - 116,175,265 (-)Ensembl
RefSeq Acc Id: NM_009371   ⟹   NP_033397
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399115,916,763 - 116,004,431 (-)NCBI
GRCm389116,087,695 - 116,175,363 (-)ENTREZGENE
MGSCv379115,996,813 - 116,084,481 (-)RGD
Celera9116,548,860 - 116,637,499 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_029575   ⟹   NP_083851
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399115,916,763 - 116,004,431 (-)NCBI
GRCm389116,087,695 - 116,175,363 (-)ENTREZGENE
MGSCv379115,996,813 - 116,084,481 (-)RGD
Celera9116,548,860 - 116,637,499 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_033397   ⟸   NM_009371
- Peptide Label: isoform 1 precursor
- UniProtKB: Q543C0 (UniProtKB/TrEMBL),   Q8BQS9 (UniProtKB/TrEMBL),   Q8BRS2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_083851   ⟸   NM_029575
- Peptide Label: isoform 2 precursor
- UniProtKB: Q62312 (UniProtKB/Swiss-Prot),   Q63947 (UniProtKB/Swiss-Prot),   Q3UG22 (UniProtKB/TrEMBL),   Q91ZR8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000035014   ⟸   ENSMUST00000035014
Ensembl Acc Id: ENSMUSP00000062333   ⟸   ENSMUST00000061101
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62312-F1-model_v2 AlphaFold Q62312 1-592 view protein structure

Promoters
RGD ID:6848487
Promoter ID:MM_ACW:52319
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour,   Lung
Transcripts:TGFBR2.CSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369116,018,841 - 116,019,341 (-)MPROMDB
RGD ID:6848486
Promoter ID:MM_ACW:52321
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour
Transcripts:TGFBR2.FSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369116,068,121 - 116,068,621 (-)MPROMDB
RGD ID:6845241
Promoter ID:MM_KWN:59066
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000035014,   ENSMUST00000061101
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369116,084,061 - 116,084,882 (-)MPROMDB
RGD ID:8671146
Promoter ID:EPDNEW_M13604
Type:initiation region
Name:Tgfbr2_1
Description:Mus musculus transforming growth factor, beta receptor II , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389116,175,284 - 116,175,344EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98729 AgrOrtholog
Ensembl Genes ENSMUSG00000032440 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000035014 ENTREZGENE
  ENSMUST00000035014.8 UniProtKB/Swiss-Prot
  ENSMUST00000061101 ENTREZGENE
  ENSMUST00000061101.12 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.60.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Snake_toxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFB_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transform_growth_fac-b_typ-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transforming_GF_b_rcpt_2_ecto UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:21813 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:98729 ENTREZGENE
NCBI Gene 21813 ENTREZGENE
PANTHER PTHR23255 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-BETA RECEPTOR TYPE-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ecTbetaR2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tgfbr2 PhenoGen
PIRSF TGFRII UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS ACTIVIN2R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL