Fgf23 (fibroblast growth factor 23) - Rat Genome Database

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Gene: Fgf23 (fibroblast growth factor 23) Mus musculus
Analyze
Symbol: Fgf23
Name: fibroblast growth factor 23
RGD ID: 734317
MGI Page MGI
Description: Enables type 1 fibroblast growth factor receptor binding activity. Involved in several processes, including ERK1 and ERK2 cascade; positive regulation of ERK1 and ERK2 cascade; and response to sodium phosphate. Acts upstream of or within several processes, including intracellular phosphate ion homeostasis; positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway; and regulation of bone mineralization. Located in extracellular space. Is expressed in compact bone; coronal suture; femur; tibia; and tongue. Used to study autosomal dominant hypophosphatemic rickets. Human ortholog(s) of this gene implicated in autosomal dominant hypophosphatemic rickets. Orthologous to human FGF23 (fibroblast growth factor 23).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: FGF-23; Fgf8b; fibroblast growth factor 8b
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396127,049,865 - 127,059,257 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6127,049,865 - 127,058,371 (+)EnsemblGRCm39 Ensembl
GRCm386127,072,902 - 127,082,296 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6127,072,902 - 127,081,408 (+)EnsemblGRCm38mm10GRCm38
MGSCv376127,022,920 - 127,031,426 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366127,038,593 - 127,046,844 (+)NCBIMGSCv36mm8
Celera6128,754,493 - 128,762,966 (+)NCBICelera
Cytogenetic Map6F3NCBI
cM Map661.92NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
1-naphthyl isothiocyanate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid  (ISO)
adenine  (ISO)
ammonium chloride  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
calcidiol  (ISO)
calcitriol  (EXP,ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (EXP)
chlorpyrifos  (ISO)
chondroitin sulfate  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
D-mannitol  (EXP,ISO)
dermatan sulfate  (EXP)
dextran sulfate  (EXP)
diazinon  (ISO)
dibenzofurans  (EXP)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
ethylparaben  (ISO)
folic acid  (EXP)
glycerol 2-phosphate  (ISO)
heparin  (EXP)
hyaluronic acid  (EXP)
hydrazine  (EXP)
lipopolysaccharide  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
ozone  (EXP)
pamidronate  (ISO)
paracetamol  (EXP)
PD 0325901  (ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
phosphorus atom  (EXP,ISO)
phosphorus(.)  (EXP,ISO)
prostaglandin E2  (EXP)
protein kinase inhibitor  (ISO)
ranitidine  (ISO)
resveratrol  (ISO)
SB 203580  (EXP)
silicon dioxide  (EXP)
sodium atom  (EXP)
sodium chlorate  (ISO)
sodium chloride  (EXP,ISO)
tetrachloromethane  (ISO)
theophylline  (ISO)
titanium dioxide  (EXP)
valproic acid  (EXP)
vitamin D  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal axial skeleton morphology  (IAGP)
abnormal blood urea nitrogen level  (IAGP)
abnormal bone mineralization  (IAGP)
abnormal bone structure  (IAGP)
abnormal bronchus morphology  (IAGP)
abnormal circulating calcium level  (IAGP)
abnormal circulating phosphate level  (IAGP)
abnormal compact bone morphology  (IAGP)
abnormal digestive system morphology  (IAGP)
abnormal femur morphology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal long bone epiphyseal plate morphology  (IAGP)
abnormal long bone hypertrophic chondrocyte zone  (IAGP)
abnormal long bone metaphysis morphology  (IAGP)
abnormal long bone morphology  (IAGP)
abnormal mineral homeostasis  (IAGP)
abnormal osteoid morphology  (IAGP)
abnormal postnatal growth/weight/body size  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal renal phosphate reabsorption  (IAGP)
abnormal reproductive system morphology  (IAGP)
abnormal rib morphology  (IAGP)
abnormal skeleton development  (IAGP)
abnormal trabecular bone morphology  (IAGP)
abnormal vertebrae morphology  (IAGP)
abnormal vitamin D level  (IAGP)
calcified artery  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral density  (IAGP)
decreased chondrocyte number  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating parathyroid hormone level  (IAGP)
decreased circulating phosphate level  (IAGP)
decreased circulating serum albumin level  (IAGP)
decreased circulating triglyceride level  (IAGP)
decreased compact bone thickness  (IAGP)
decreased diameter of femur  (IAGP)
decreased long bone epiphyseal plate size  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased volumetric bone mineral density  (IAGP)
emphysema  (IAGP)
epidermal cyst  (IAGP)
fragile skeleton  (IAGP)
hypoglycemia  (IAGP)
improved glucose tolerance  (IAGP)
increased blood urea nitrogen level  (IAGP)
increased bone mineral content  (IAGP)
increased bone mineral density  (IAGP)
increased circulating alkaline phosphatase level  (IAGP)
increased circulating calcium level  (IAGP)
increased circulating cholesterol level  (IAGP)
increased circulating parathyroid hormone level  (IAGP)
increased circulating phosphate level  (IAGP)
increased diameter of femur  (IAGP)
increased osteoid thickness  (IAGP)
infertility  (IAGP)
long femur  (IAGP)
nephrocalcinosis  (IAGP)
osteomalacia  (IAGP)
postnatal growth retardation  (IAGP)
premature death  (IAGP)
rickets  (IAGP)
short femur  (IAGP)
small spleen  (IAGP)
spleen hypoplasia  (IAGP)
thickened long bone epiphysis  (IAGP)
thin skin  (IAGP)
thymus atrophy  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. The relationship between fibroblast growth factor 23 and osteoporosis in postmenopausal women. Celik E, etal., Minerva Med. 2013 Oct;104(5):497-504.
2. Amelioration of the premature ageing-like features of Fgf-23 knockout mice by genetically restoring the systemic actions of FGF-23. DeLuca S, etal., J Pathol. 2008 Nov;216(3):345-55. doi: 10.1002/path.2409.
3. Fibroblast growth factor 23 contributes to diminished bone mineral density in childhood inflammatory bowel disease. El-Hodhod MA, etal., BMC Gastroenterol. 2012 May 2;12:44. doi: 10.1186/1471-230X-12-44.
4. Parathyroid cell resistance to fibroblast growth factor 23 in secondary hyperparathyroidism of chronic kidney disease. Galitzer H, etal., Kidney Int. 2010 Feb;77(3):211-8. doi: 10.1038/ki.2009.464. Epub 2009 Dec 16.
5. An autosomal dominant hypophosphatemic rickets phenotype in a Tunisian family caused by a new FGF23 missense mutation. Gribaa M, etal., J Bone Miner Metab. 2010;28(1):111-5. doi: 10.1007/s00774-009-0111-5. Epub 2009 Aug 5.
6. Premature aging in vitamin D receptor mutant mice. Keisala T, etal., J Steroid Biochem Mol Biol. 2009 Jul;115(3-5):91-7. doi: 10.1016/j.jsbmb.2009.03.007. Epub 2009 Mar 31.
7. Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis. Larsson T, etal., Endocrinology. 2004 Jul;145(7):3087-94. Epub 2004 Feb 26.
8. MGDs mouse GO annotations MGD data from the GO Consortium
9. MGD IEA MGD IEA
10. Serum fibroblast growth factor-23 (FGF-23) and fracture risk in elderly men. Mirza MA, etal., J Bone Miner Res. 2011 Apr;26(4):857-64. doi: 10.1002/jbmr.263.
11. Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. NO_AUTHOR Nat Genet. 2000 Nov;26(3):345-8.
12. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16. Mouse MP Annotation Import Pipeline RGD automated import pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Regulation of fibroblast growth factor 23 production in bone in uremic rats. Saji F, etal., Nephron Physiol. 2009;111(4):p59-66. doi: 10.1159/000210389. Epub 2009 Apr 1.
20. Renal expression of FGF23 in progressive renal disease of diabetes and the effect of ACE inhibitor. Zanchi C, etal., PLoS One. 2013 Aug 14;8(8):e70775. doi: 10.1371/journal.pone.0070775. eCollection 2013.
Additional References at PubMed
PMID:10349636   PMID:11032749   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11276432   PMID:11900978   PMID:12032146   PMID:12477932   PMID:12519781   PMID:12791601   PMID:12874285  
PMID:14517998   PMID:14681479   PMID:14733920   PMID:14966565   PMID:15284207   PMID:15531762   PMID:15579309   PMID:15869926   PMID:15885032   PMID:15998839   PMID:16012775   PMID:16020653  
PMID:16076377   PMID:16105045   PMID:16123981   PMID:16141072   PMID:16141073   PMID:16144964   PMID:16436388   PMID:16436465   PMID:16449303   PMID:16597685   PMID:17086194   PMID:17099775  
PMID:17123805   PMID:17148678   PMID:17174939   PMID:17333246   PMID:17494882   PMID:17554146   PMID:17848631   PMID:17855636   PMID:17911089   PMID:17942069   PMID:18346951   PMID:18442315  
PMID:18528324   PMID:18559986   PMID:18678710   PMID:18688277   PMID:18753255   PMID:18835926   PMID:18984852   PMID:19063940   PMID:19213845   PMID:19357251   PMID:19480830   PMID:19483273  
PMID:19515808   PMID:19544582   PMID:19549991   PMID:19556340   PMID:19584304   PMID:19819968   PMID:19933269   PMID:19966287   PMID:20040496   PMID:20200981   PMID:20299748   PMID:20348033  
PMID:20466874   PMID:20499360   PMID:20562862   PMID:20583265   PMID:20618171   PMID:20675303   PMID:20734454   PMID:21037388   PMID:21427221   PMID:21472778   PMID:21488937   PMID:21507898  
PMID:21561999   PMID:21590742   PMID:21678127   PMID:21726676   PMID:21812026   PMID:21824606   PMID:21873635   PMID:21876757   PMID:21896668   PMID:21908609   PMID:21985788   PMID:22006328  
PMID:22031097   PMID:22275752   PMID:22285620   PMID:22294750   PMID:22359666   PMID:22360923   PMID:22370560   PMID:22396163   PMID:22615579   PMID:22615584   PMID:22647635   PMID:22647968  
PMID:22739976   PMID:22836867   PMID:22930691   PMID:22970174   PMID:23038738   PMID:23095356   PMID:23187128   PMID:23233539   PMID:23235154   PMID:23443925   PMID:23451204   PMID:23523568  
PMID:23577141   PMID:23635517   PMID:23747333   PMID:23873717   PMID:23884339   PMID:23895994   PMID:24019880   PMID:24038141   PMID:24068282   PMID:24140714   PMID:24198358   PMID:24259513  
PMID:24302726   PMID:24348262   PMID:24402093   PMID:24434184   PMID:24470103   PMID:24487286   PMID:24509850   PMID:24525546   PMID:24601885   PMID:24710520   PMID:24797667   PMID:24952961  
PMID:25007710   PMID:25051439   PMID:25053401   PMID:25089825   PMID:25243481   PMID:25475745   PMID:25665715   PMID:25858796   PMID:26094741   PMID:26148725   PMID:26235988   PMID:26273529  
PMID:26311115   PMID:26428657   PMID:26476373   PMID:26527066   PMID:26588476   PMID:26748348   PMID:26751835   PMID:26762170   PMID:26784541   PMID:26792657   PMID:27035636   PMID:27085781  
PMID:27457912   PMID:27498418   PMID:27579618   PMID:27732085   PMID:27733366   PMID:27871077   PMID:27879395   PMID:27929669   PMID:28005411   PMID:28183805   PMID:28324013   PMID:28425622  
PMID:28512310   PMID:28600880   PMID:28794403   PMID:28877877   PMID:28900153   PMID:28919046   PMID:29073196   PMID:29395333   PMID:29481308   PMID:29561836   PMID:29599772   PMID:29635291  
PMID:29718273   PMID:29735309   PMID:29751971   PMID:29861059   PMID:29861060   PMID:29942284   PMID:29993278   PMID:30791553   PMID:30830862   PMID:30852297   PMID:30911673   PMID:31097591  
PMID:31301888   PMID:31420162   PMID:31484825   PMID:31599948   PMID:31758181   PMID:31801907   PMID:31928110   PMID:32065590   PMID:32154933   PMID:32325033   PMID:32476270   PMID:32729975  
PMID:32759495   PMID:32792620   PMID:32853180   PMID:33057033   PMID:33150413   PMID:33295868   PMID:33299044   PMID:33460402   PMID:33475190   PMID:33512467   PMID:33729479   PMID:33731726  
PMID:33853949   PMID:33866326   PMID:33929896   PMID:34103575   PMID:34245331   PMID:34304712   PMID:34929174   PMID:35020897   PMID:35042527   PMID:35118076   PMID:35216216   PMID:35428804  
PMID:35656701   PMID:35807756   PMID:36162588   PMID:36244766   PMID:36624273   PMID:36943390   PMID:37053547   PMID:37142227   PMID:37256933   PMID:37439399   PMID:37711045   PMID:37943605  
PMID:37972265   PMID:37992803   PMID:38066669   PMID:38189228   PMID:38299214   PMID:38395995   PMID:38479224  


Genomics

Comparative Map Data
Fgf23
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396127,049,865 - 127,059,257 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6127,049,865 - 127,058,371 (+)EnsemblGRCm39 Ensembl
GRCm386127,072,902 - 127,082,296 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6127,072,902 - 127,081,408 (+)EnsemblGRCm38mm10GRCm38
MGSCv376127,022,920 - 127,031,426 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366127,038,593 - 127,046,844 (+)NCBIMGSCv36mm8
Celera6128,754,493 - 128,762,966 (+)NCBICelera
Cytogenetic Map6F3NCBI
cM Map661.92NCBI
FGF23
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38124,368,227 - 4,379,712 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl124,368,227 - 4,379,712 (-)EnsemblGRCh38hg38GRCh38
GRCh37124,477,393 - 4,488,878 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36124,347,654 - 4,359,155 (-)NCBINCBI36Build 36hg18NCBI36
Build 34124,347,653 - 4,359,155NCBI
Celera126,099,463 - 6,110,952 (-)NCBICelera
Cytogenetic Map12p13.32NCBI
HuRef124,334,034 - 4,345,523 (-)NCBIHuRef
CHM1_1124,477,002 - 4,488,504 (-)NCBICHM1_1
T2T-CHM13v2.0124,375,010 - 4,386,480 (-)NCBIT2T-CHM13v2.0
Fgf23
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84161,600,439 - 161,609,991 (+)NCBIGRCr8
mRatBN7.24159,914,267 - 159,923,821 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4159,914,272 - 159,923,821 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4166,144,203 - 166,151,883 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04161,927,113 - 161,934,785 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04160,561,155 - 160,568,833 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04159,622,404 - 159,630,082 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4159,622,404 - 159,630,082 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04231,971,932 - 231,990,610 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44163,468,604 - 163,476,325 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14163,713,539 - 163,721,261 (+)NCBI
Celera4148,629,372 - 148,637,127 (+)NCBICelera
Cytogenetic Map4q42NCBI
Fgf23
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554132,182,459 - 2,192,279 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554132,182,459 - 2,192,279 (-)NCBIChiLan1.0ChiLan1.0
FGF23
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2109,910,396 - 9,919,599 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1129,902,683 - 9,916,357 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0124,479,116 - 4,488,797 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1124,400,802 - 4,412,000 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl124,400,802 - 4,412,000 (-)Ensemblpanpan1.1panPan2
FGF23
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12740,501,655 - 40,511,785 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2740,501,731 - 40,509,766 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha276,170,287 - 6,180,384 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02740,857,426 - 40,867,540 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2740,857,191 - 40,866,460 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12740,746,195 - 40,756,275 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02740,771,149 - 40,781,234 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0275,580,979 - 5,591,077 (-)NCBIUU_Cfam_GSD_1.0
Fgf23
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945104,622,105 - 104,630,138 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366064,555,034 - 4,561,961 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366064,555,034 - 4,561,961 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGF23
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl566,028,776 - 66,038,740 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1566,028,591 - 66,038,078 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2568,250,524 - 68,260,006 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FGF23
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1114,398,318 - 4,408,415 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl114,398,675 - 4,407,209 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660633,836,189 - 3,845,260 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fgf23
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248601,479,303 - 1,486,323 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248601,478,712 - 1,486,808 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fgf23
254 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:452
Count of miRNA genes:331
Interacting mature miRNAs:366
Transcripts:ENSMUST00000000186
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645290993128811995Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46912919136400690Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648696934148351498Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673476983134676963Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683690851146954059Mouse
11353842Bmiq4_mbody mass index QTL 4 (mouse)692584287146330736Mouse
1301292Cfbw2_mcystic fibrosis body weight 2 (mouse)Not determined694981612128981699Mouse
11040599Lmr4b_mleishmaniasis resistance 4b (mouse)696324286130324483Mouse
1300704Cia3_mcollagen induced arthritis QTL 3 (mouse)Not determined696324286130324483Mouse
4141940W6q5_mweight 6 weeks QTL 5 (mouse)Not determined96632912146535124Mouse
4142416Egq11_mearly growth QTL 11 (mouse)Not determined96632912146535124Mouse
1357555Tesq2_mtestis weight QTL 2 (mouse)Not determined696632912146535124Mouse
10043923Bhr7_mbronchial hyperresponsiveness 7 (mouse)Not determined698219814132219938Mouse
1301518Bbaa5_mB.burgdorferi-associated arthritis 5 (mouse)Not determined698483798145881170Mouse
1301923Lith6_mlithogenic gene 6 (mouse)Not determined698694477132694676Mouse
1301915Chab3_mcholesterol absorption 3 (mouse)Not determined698908709132916997Mouse
1302131Bmd8_mbone mineral density 8 (mouse)Not determined699132089133132228Mouse
1300887Pabr1_mplasma apolipoprotein B (human) regulator 1 (mouse)Not determined6103754405136400690Mouse
1357806Aaj3_manxiety in A/J 3 (mouse)Not determined6104480321136400690Mouse
10412207Cypr5_mcytokine production 5 (mouse)Not determined6110815180144815323Mouse
13463481Mcvq14_mmean corpuscular volume QTL 14 (mouse)6111142448145142541Mouse
11252138Clas1_mcarcinogen-induced lung adenoma susceptibility 1 (mouse)6112246918146954059Mouse
4140980Mvwf2_mmodifier of von Willebrand factor 2 (mouse)Not determined114345693145601739Mouse
1301658Radpf3_mradiation pulmonary fibrosis 3 (mouse)Not determined6115219814146330736Mouse
4141889Qui_mquinine sensitivity, taste (mouse)Not determined115546805149549364Mouse
4141194Cyx_mcycloheximide tasting (mouse)Not determined115546805149549364Mouse
4141295Rua_mraffinose acetate tasting (mouse)Not determined115546805149549364Mouse
1301927Etohcta6_methanol conditioned taste aversion 6 (mouse)Not determined6115578005149578150Mouse
1301083Bhr5_mbronchial hyperresponsiveness 5 (mouse)Not determined6115694477132578150Mouse
4141064Ath37_matherosclerosis 37 (mouse)Not determined6116641858128495988Mouse
4142079Skmw15_mskeletal muscle weight 15 (mouse)Not determined6116829851149588044Mouse
1301152Athsq2_matherosclerosis susceptibility QTL 2 (mouse)Not determined6117059949149588044Mouse
1301804Bulb2_mbulb size 2 (mouse)Not determined6120416806149588044Mouse
10449436Pas17_mpulmonary adenoma susceptibility 17 (mouse)6124334273145601739Mouse
1302089Wta2_mweight adult 2 (mouse)Not determined6125269523149588044Mouse
4141611Btts_mbitterness tasting (mouse)Not determined6125333609134096586Mouse

Markers in Region
Fgf23  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6F3UniSTS
cM Map6 UniSTS
Fgf23  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6F3UniSTS
cM Map6 UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000000186   ⟹   ENSMUSP00000000186
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6127,049,865 - 127,058,371 (+)Ensembl
GRCm38.p6 Ensembl6127,072,902 - 127,081,408 (+)Ensembl
RefSeq Acc Id: NM_022657   ⟹   NP_073148
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396127,049,869 - 127,059,257 (+)NCBI
GRCm386127,072,902 - 127,082,296 (+)NCBI
MGSCv376127,022,920 - 127,031,426 (+)RGD
Celera6128,754,493 - 128,763,832 (+)NCBI
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036152259   ⟹   XP_036008152
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396127,049,865 - 127,059,257 (+)NCBI
Sequence:
RefSeq Acc Id: NP_073148   ⟸   NM_022657
- Peptide Label: precursor
- UniProtKB: Q9EPC2 (UniProtKB/Swiss-Prot),   Q3U1V5 (UniProtKB/TrEMBL),   Q0VBJ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000000186   ⟸   ENSMUST00000000186
RefSeq Acc Id: XP_036008152   ⟸   XM_036152259
- Peptide Label: isoform X1
- UniProtKB: Q0VBJ8 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9EPC2-F1-model_v2 AlphaFold Q9EPC2 1-251 view protein structure

Promoters
RGD ID:6847993
Promoter ID:MM_ACW:42779
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   ES_Cell
Transcripts:FGF23.BSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366127,029,861 - 127,030,361 (+)MPROMDB
RGD ID:6891100
Promoter ID:EPDNEW_M9001
Type:single initiation site
Name:Fgf23_1
Description:Mus musculus fibroblast growth factor 23 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm386127,072,907 - 127,072,967EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1891427 AgrOrtholog
Ensembl Genes ENSMUSG00000000182 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000000186 ENTREZGENE
  ENSMUST00000000186.9 UniProtKB/Swiss-Prot
Gene3D-CATH 2.80.10.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Fibroblast_GF_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL1/FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:64654 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1891427 ENTREZGENE
NCBI Gene 64654 ENTREZGENE
PANTHER PTHR11486 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11486:SF69 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fgf23 PhenoGen
PROSITE HBGF_FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50353 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt FGF23_MOUSE UniProtKB/Swiss-Prot
  Q0VBJ8 ENTREZGENE, UniProtKB/TrEMBL
  Q3U1V5 ENTREZGENE, UniProtKB/TrEMBL
  Q9EPC2 ENTREZGENE