Siah2 (siah E3 ubiquitin protein ligase 2) - Rat Genome Database

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Gene: Siah2 (siah E3 ubiquitin protein ligase 2) Mus musculus
Analyze
Symbol: Siah2
Name: siah E3 ubiquitin protein ligase 2
RGD ID: 734304
MGI Page MGI
Description: Enables ubiquitin protein ligase activity. Involved in regulation of circadian rhythm and ubiquitin-dependent protein catabolic process. Predicted to be located in several cellular components, including early endosome; neuronal cell body; and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including bone; brain; gonad; hemolymphoid system gland; and sensory organ. Orthologous to human SIAH2 (siah E3 ubiquitin protein ligase 2).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: AA415433; E3 ubiquitin-protein ligase SIAH2; mSiah2; RING-type E3 ubiquitin transferase SIAH2; seven in absentia 2; seven in absentia homolog 2; Si; siah-2; Sinh2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39358,582,370 - 58,599,857 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl358,582,359 - 58,599,821 (-)EnsemblGRCm39 Ensembl
GRCm38358,674,949 - 58,692,439 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl358,674,938 - 58,692,400 (-)EnsemblGRCm38mm10GRCm38
MGSCv37358,478,871 - 58,496,310 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36358,762,878 - 58,780,317 (-)NCBIMGSCv36mm8
Celera358,369,358 - 58,387,000 (-)NCBICelera
Cytogenetic Map3DNCBI
cM Map328.68NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2,4-trimethylbenzene  (ISO)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (EXP)
benzo[a]pyrene diol epoxide I  (ISO)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (ISO)
Butylparaben  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
cidofovir anhydrous  (ISO)
ciguatoxin CTX1B  (EXP)
cisplatin  (ISO)
clodronic acid  (ISO)
clomiphene  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (EXP)
Dibutyl phosphate  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
erlotinib hydrochloride  (ISO)
estrone  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
fenofibrate  (ISO)
folic acid  (EXP)
fulvestrant  (ISO)
furan  (ISO)
genistein  (ISO)
gentamycin  (ISO)
hexestrol  (ISO)
ICI-164384  (ISO)
ifosfamide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
manganese(II) chloride  (ISO)
mestranol  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylparaben  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
naphthalenes  (ISO)
paracetamol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phytoestrogen  (ISO)
picene  (ISO)
pirinixic acid  (EXP)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
SB 431542  (ISO)
silicon dioxide  (EXP)
Soman  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP)
temozolomide  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
troglitazone  (EXP)
trovafloxacin  (EXP)
tunicamycin  (EXP)
valproic acid  (EXP,ISO)
vincristine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting. Hall JM and McDonnell DP, Mol Interv. 2005 Dec;5(6):343-57.
2. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Hayes JD and Dinkova-Kostova AT, Trends Biochem Sci. 2014 Apr;39(4):199-218. doi: 10.1016/j.tibs.2014.02.002. Epub 2014 Mar 16.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7895278   PMID:8404535   PMID:9143490   PMID:9637679   PMID:10349636   PMID:10681424   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11257006   PMID:11884614  
PMID:12411493   PMID:12417719   PMID:12477932   PMID:12952940   PMID:14610273   PMID:14645235   PMID:14645526   PMID:15210114   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16602821  
PMID:16888801   PMID:18323779   PMID:18946040   PMID:19712206   PMID:20059953   PMID:20609350   PMID:21109632   PMID:21389087   PMID:21677750   PMID:21873635   PMID:22008794   PMID:22055192  
PMID:22099302   PMID:22294748   PMID:22354750   PMID:23455005   PMID:23518348   PMID:23644657   PMID:24061476   PMID:24809345   PMID:25561546   PMID:26070566   PMID:26160177   PMID:26275748  
PMID:26380945   PMID:26392558   PMID:27136357   PMID:27178982   PMID:27864366   PMID:28338984   PMID:29892230   PMID:30987673   PMID:31825833   PMID:31911617   PMID:32042051   PMID:33082319  
PMID:33155406   PMID:35789210   PMID:37078793  


Genomics

Comparative Map Data
Siah2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39358,582,370 - 58,599,857 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl358,582,359 - 58,599,821 (-)EnsemblGRCm39 Ensembl
GRCm38358,674,949 - 58,692,439 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl358,674,938 - 58,692,400 (-)EnsemblGRCm38mm10GRCm38
MGSCv37358,478,871 - 58,496,310 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36358,762,878 - 58,780,317 (-)NCBIMGSCv36mm8
Celera358,369,358 - 58,387,000 (-)NCBICelera
Cytogenetic Map3DNCBI
cM Map328.68NCBI
SIAH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383150,741,125 - 150,763,169 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3150,741,125 - 150,763,477 (-)EnsemblGRCh38hg38GRCh38
GRCh373150,458,912 - 150,480,956 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363151,941,600 - 151,963,953 (-)NCBINCBI36Build 36hg18NCBI36
Build 343151,941,608 - 151,963,961NCBI
Celera3148,871,981 - 148,894,332 (-)NCBICelera
Cytogenetic Map3q25.1NCBI
HuRef3147,832,386 - 147,876,859 (-)NCBIHuRef
CHM1_13150,421,938 - 150,444,291 (-)NCBICHM1_1
T2T-CHM13v2.03153,492,334 - 153,514,363 (-)NCBIT2T-CHM13v2.0
Siah2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82145,063,847 - 145,081,675 (-)NCBIGRCr8
mRatBN7.22142,913,924 - 142,931,752 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2142,914,003 - 142,931,950 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2149,552,206 - 149,570,039 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02147,658,831 - 147,676,654 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02142,291,261 - 142,309,088 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02148,874,151 - 148,891,900 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2148,874,151 - 148,891,900 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02168,292,053 - 168,309,802 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42148,022,641 - 148,040,390 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12147,972,605 - 147,990,353 (-)NCBI
Celera2137,342,181 - 137,359,932 (-)NCBICelera
Cytogenetic Map2q26NCBI
Siah2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554481,907,401 - 1,926,445 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554481,907,478 - 1,926,445 (-)NCBIChiLan1.0ChiLan1.0
SIAH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22148,630,486 - 148,652,743 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13148,635,203 - 148,657,271 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03147,759,375 - 147,781,639 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13155,332,751 - 155,354,135 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3155,332,751 - 155,354,139 (-)Ensemblpanpan1.1panPan2
SIAH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12345,366,343 - 45,418,960 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2345,341,199 - 45,385,546 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2345,233,446 - 45,252,449 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02345,995,112 - 46,014,122 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2345,996,108 - 46,014,111 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12345,585,094 - 45,604,128 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02345,637,159 - 45,656,202 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02345,913,240 - 45,932,290 (-)NCBIUU_Cfam_GSD_1.0
Siah2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560290,635,588 - 90,651,834 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367581,116,056 - 1,213,442 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367581,115,980 - 1,132,225 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIAH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1390,949,021 - 90,971,411 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11390,951,798 - 90,971,538 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21399,076,306 - 99,096,119 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SIAH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11539,939,209 - 39,960,750 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1539,939,832 - 39,959,734 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604112,757,953 - 12,779,570 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Siah2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473028,158,750 - 28,178,810 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473028,159,096 - 28,178,832 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Siah2
519 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:450
Count of miRNA genes:333
Interacting mature miRNAs:380
Transcripts:ENSMUST00000070368, ENSMUST00000145032
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
14746977Manh53_mmandible shape 53 (mouse)33592528069925280Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)351907421102307316Mouse
15039332Nmrs6_mNAFLD-associated magnetic resonance shift 6 (mouse)33417074168170741Mouse
1301585Cd4ts1_mCD4 T cell subset 1 (mouse)Not determined33970410273704231Mouse
4141116Lgaq4_mlate growth adjusted QTL 4 (mouse)Not determined1024922183184946Mouse
4141563Lgq3_mlate growth QTL 3 (mouse)Not determined1024922183184946Mouse
1357584Splq6_mspleen weight QTL 6 (mouse)Not determined31024922183184946Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
11041901Lmr11b_mleishmaniasis resistance 11b (mouse)33970410273704231Mouse
1357585Manln3_mmandible length 3 (mouse)Not determined35262550986625745Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)343954435101607316Mouse
13464139Nhdlq17_mnon-HDL QTL 17 (mouse)35292318386923183Mouse
1300895Hdl5_mHDL level 5 (mouse)Not determined34949500583495118Mouse
15039336Nmrs2_mNAFLD-associated magnetic resonance shift 2 (mouse)33457610368576103Mouse
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
1301917Tshp4_mtooth shape 4 (mouse)Not determined35262550986625745Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
1301824Susp_msuppressor of superoxide production (mouse)Not determined34949500583495118Mouse
1357440Hrtpq1_mheart weight percentage QTL 1 (mouse)Not determined31024922183184946Mouse
10755516Amzn1_manatomical modifier of Zfp423 1 (mouse)33970410273704231Mouse
1558925Hivan1_mHIV-associated nephropathy 1 (mouse)Not determined3758617468716946Mouse
9587784Afw13_mabdominal fat weight QTL 13 (mouse)Not determined33375204567752228Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
39128206Lwq18_mliver weight QTL 18 (mouse)31024922183184946Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1300593Skull4_mskull morphology 4 (mouse)Not determined35262550986625745Mouse
4141079Ath23_matherosclerosis 23 (mouse)Not determined4935758183357581Mouse
18337272Bmd46_mbone mineral density 46, males (mouse)33540742169407421Mouse
11039513Ltpr3a_mLeishmania tropica response 3a (mouse)33970410273704231Mouse
1300961Bh4p_mbar holding four paws (mouse)Not determined33183785465837997Mouse
10043882Bwtq13_mbody weight QTL 13 (mouse)Not determined33375204567752228Mouse
10412073Ssen2_msuseptibility to Sendai virus 2 (mouse)Not determined33353546567535615Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356704102100464137Mouse
4141255W10q3_mweight 10 weeks QTL 3 (mouse)Not determined1024922183184946Mouse
1300587Aod2_mautoimmune ovarian dysgenesis 2 (mouse)Not determined33717974268716946Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse
26884389Skwq10_mskull length QTL 10, 16 week (mouse)34395443565307421Mouse

Markers in Region
AA415433  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38358,674,997 - 58,675,113UniSTSGRCm38
MGSCv37358,478,919 - 58,479,035UniSTSGRCm37
Celera358,369,406 - 58,369,522UniSTS
Cytogenetic Map3DUniSTS
cM Map335.0UniSTS
Whitehead/MRC_RH3528.05UniSTS


Sequence


Ensembl Acc Id: ENSMUST00000070368   ⟹   ENSMUSP00000067496
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl358,582,359 - 58,599,821 (-)Ensembl
GRCm38.p6 Ensembl358,674,938 - 58,692,400 (-)Ensembl
Ensembl Acc Id: ENSMUST00000145032
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl358,583,597 - 58,593,458 (-)Ensembl
GRCm38.p6 Ensembl358,676,176 - 58,686,037 (-)Ensembl
RefSeq Acc Id: NM_009174   ⟹   NP_033200
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39358,582,370 - 58,599,809 (-)NCBI
GRCm38358,674,949 - 58,692,388 (-)NCBI
MGSCv37358,478,871 - 58,496,310 (-)RGD
Celera358,369,358 - 58,387,000 (-)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XR_001783671
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39358,583,774 - 58,599,857 (-)NCBI
GRCm38358,676,353 - 58,692,439 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_033200 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH58400 (Get FASTA)   NCBI Sequence Viewer  
  BAE24087 (Get FASTA)   NCBI Sequence Viewer  
  BAE28809 (Get FASTA)   NCBI Sequence Viewer  
  CAA79632 (Get FASTA)   NCBI Sequence Viewer  
  EDL35339 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000067496
  ENSMUSP00000067496.8
GenBank Protein Q06986 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_033200   ⟸   NM_009174
- UniProtKB: Q06986 (UniProtKB/Swiss-Prot),   Q3UEV2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000067496   ⟸   ENSMUST00000070368
Protein Domains
RING-type   SIAH-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q06986-F1-model_v2 AlphaFold Q06986 1-325 view protein structure

Promoters
RGD ID:6834458
Promoter ID:MM_KWN:34409
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:OTTMUST00000073093
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36358,490,384 - 58,490,884 (-)MPROMDB
RGD ID:6833213
Promoter ID:MM_KWN:34410
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:AK017132_4930593A02RIK,   ENSMUST00000070368,   ENSMUST00000099089,   UC008PIB.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36358,494,766 - 58,496,532 (+)MPROMDB
RGD ID:6880720
Promoter ID:EPDNEW_M3811
Type:initiation region
Name:Siah2_2
Description:Mus musculus siah E3 ubiquitin protein ligase 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M3812  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38358,692,064 - 58,692,124EPDNEW
RGD ID:6880722
Promoter ID:EPDNEW_M3812
Type:multiple initiation site
Name:Siah2_1
Description:Mus musculus siah E3 ubiquitin protein ligase 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M3811  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38358,692,401 - 58,692,461EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:108062 AgrOrtholog
Ensembl Genes ENSMUSG00000036432 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000070368 ENTREZGENE
  ENSMUST00000070368.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 7-in-absentia-prot_TRAF-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SINA-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sina-like_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRAF-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_SIAH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20439 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:108062 ENTREZGENE
NCBI Gene 20439 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE SIAH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR45877 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sina UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sina_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sina_ZnF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Siah2 PhenoGen
PROSITE ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_SIAH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRAF domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Q06986 ENTREZGENE
  Q3UEV2 ENTREZGENE, UniProtKB/TrEMBL
  Q3UT93_MOUSE UniProtKB/TrEMBL
  SIAH2_MOUSE UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-31 Siah2  siah E3 ubiquitin protein ligase 2    seven in absentia 2  Symbol and/or name change 5135510 APPROVED