Stk39 (serine/threonine kinase 39) - Rat Genome Database

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Gene: Stk39 (serine/threonine kinase 39) Mus musculus
Analyze
Symbol: Stk39
Name: serine/threonine kinase 39
RGD ID: 734215
MGI Page MGI
Description: Enables protein serine/threonine kinase activity. Involved in several processes, including intracellular chloride ion homeostasis; negative regulation of transport; and protein phosphorylation. Acts upstream of or within monoatomic ion homeostasis; regulation of blood pressure; and regulation of inflammatory response. Located in basolateral plasma membrane. Is active in apical plasma membrane and cell body. Is expressed in brain and metanephros. Used to study Gitelman syndrome and pseudohypoaldosteronism. Orthologous to human STK39 (serine/threonine kinase 39).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AW227544; AW556857; DCHT; Gm50618; kidney-specific SPAK; LOC108168764; predicted gene, 50618; R; RF00; RF005; Rnl5; S; serine/threonine kinase 39, STE20/SPS1 homolog; serine/threonine-protein kinase 39; SPAK; Ste-20 related kinase; ste-20-related kinase; STE20/SPS1-related proline-alanine-rich protein kinase; uncharacterized LOC108168764
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39268,040,789 - 68,302,381 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl268,040,789 - 68,302,612 (-)EnsemblGRCm39 Ensembl
GRCm38268,210,445 - 68,472,108 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl268,210,445 - 68,472,268 (-)EnsemblGRCm38mm10GRCm38
MGSCv37268,048,504 - 68,310,038 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36268,011,286 - 68,272,820 (-)NCBIMGSCv36mm8
Celera269,878,607 - 70,140,879 (-)NCBICelera
Cytogenetic Map2C1.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (EXP)
carboplatin  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
choline  (EXP)
cisplatin  (ISO)
cobalt atom  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
dactolisib  (EXP)
daidzein  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
eplerenone  (EXP)
equol  (ISO)
ethanol  (EXP)
flavonoids  (ISO)
folic acid  (EXP,ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (ISO)
genistein  (ISO)
gentamycin  (ISO)
hydrogen peroxide  (ISO)
inulin  (EXP)
ivermectin  (ISO)
L-methionine  (EXP)
methapyrilene  (ISO)
methoxyacetic acid  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosomorpholine  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
permethrin  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
Rebamipide  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
temozolomide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell volume homeostasis  (IEA,ISO)
cellular hyperosmotic response  (IBA,IEA,ISO)
cellular hypotonic response  (IGI,ISO)
cellular response to chemokine  (ISO)
cellular response to potassium ion  (IDA)
chemokine (C-X-C motif) ligand 12 signaling pathway  (IEA,ISO)
chromatin remodeling  (IEA)
inflammatory response  (IMP)
intracellular chloride ion homeostasis  (IGI)
intracellular signal transduction  (IBA,IGI,ISO)
macrophage activation  (IMP)
maintenance of lens transparency  (IMP)
monoatomic ion homeostasis  (IMP)
negative regulation of creatine transmembrane transporter activity  (ISO)
negative regulation of pancreatic juice secretion  (IMP)
negative regulation of potassium ion transmembrane transport  (IGI,ISO)
negative regulation of potassium ion transmembrane transporter activity  (IGI,ISO)
negative regulation of sodium ion transmembrane transporter activity  (ISO)
peptidyl-serine phosphorylation  (ISO)
peptidyl-threonine phosphorylation  (IGI,IMP,ISO,ISS)
positive regulation of p38MAPK cascade  (ISO,ISS)
positive regulation of potassium ion import across plasma membrane  (ISO)
positive regulation of potassium ion transport  (IEA,ISO)
positive regulation of sodium ion import across plasma membrane  (ISO)
positive regulation of T cell chemotaxis  (IBA,IEA,ISO)
protein autophosphorylation  (IMP,ISO,ISS)
protein phosphorylation  (IMP,ISO)
regulation of blood pressure  (IMP)
regulation of inflammatory response  (IDA)
renal sodium ion absorption  (IEA,ISO)
response to aldosterone  (IGI)
response to dietary excess  (IMP)
signal transduction  (ISO)
sodium ion transmembrane transport  (IMP)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. SPAK, a STE20/SPS1-related kinase that activates the p38 pathway. Johnston AM, etal., Oncogene 2000 Aug 31;19(37):4290-7.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12386165   PMID:12477932   PMID:14563843   PMID:15489334   PMID:15930150   PMID:16141072   PMID:16141073  
PMID:16284245   PMID:16382158   PMID:16530727   PMID:17595523   PMID:18787102   PMID:18800028   PMID:19008908   PMID:19240212   PMID:19307180   PMID:19343169   PMID:19717643   PMID:20006650  
PMID:20060021   PMID:20091762   PMID:20231443   PMID:20385770   PMID:20442269   PMID:20463172   PMID:20813865   PMID:21317537   PMID:21321328   PMID:21486947   PMID:21677750   PMID:21705622  
PMID:21768522   PMID:21873635   PMID:21907141   PMID:22977235   PMID:23235437   PMID:23393317   PMID:23499375   PMID:24019400   PMID:24039833   PMID:24058604   PMID:24133122   PMID:24173353  
PMID:24393035   PMID:24761002   PMID:24799612   PMID:24808538   PMID:24811174   PMID:25161031   PMID:25164821   PMID:25322850   PMID:25362046   PMID:25477470   PMID:25515571   PMID:25565204  
PMID:25651563   PMID:25761881   PMID:25797415   PMID:25893600   PMID:25994507   PMID:26108786   PMID:26160150   PMID:26208601   PMID:26728390   PMID:26861815   PMID:27068441   PMID:27519267  
PMID:27782176   PMID:27853306   PMID:28442491   PMID:28864211   PMID:28877076   PMID:29066461   PMID:29122955   PMID:29412702   PMID:29459793   PMID:29483157   PMID:30714348   PMID:30973865  
PMID:31615901   PMID:31736353   PMID:31786261   PMID:32325033   PMID:32581705   PMID:32714200   PMID:33051000   PMID:33588817   PMID:33719576   PMID:35069250   PMID:35379995   PMID:36114006  
PMID:36662229   PMID:36736544   PMID:37676724   PMID:38057317   PMID:38355793   PMID:38465625   PMID:38925962   PMID:39298551   PMID:39984435  


Genomics

Comparative Map Data
Stk39
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39268,040,789 - 68,302,381 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl268,040,789 - 68,302,612 (-)EnsemblGRCm39 Ensembl
GRCm38268,210,445 - 68,472,108 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl268,210,445 - 68,472,268 (-)EnsemblGRCm38mm10GRCm38
MGSCv37268,048,504 - 68,310,038 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36268,011,286 - 68,272,820 (-)NCBIMGSCv36mm8
Celera269,878,607 - 70,140,879 (-)NCBICelera
Cytogenetic Map2C1.3NCBI
STK39
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382167,954,022 - 168,247,595 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2167,954,020 - 168,247,595 (-)EnsemblGRCh38hg38GRCh38
GRCh372168,810,532 - 169,104,105 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362168,518,776 - 168,812,351 (-)NCBINCBI36Build 36hg18NCBI36
Build 342168,636,037 - 168,929,612NCBI
Celera2162,419,314 - 162,712,878 (-)NCBICelera
Cytogenetic Map2q24.3NCBI
HuRef2160,690,590 - 160,918,691 (-)NCBIHuRef
CHM1_12168,816,415 - 169,109,972 (-)NCBICHM1_1
T2T-CHM13v2.02168,411,922 - 168,705,066 (-)NCBIT2T-CHM13v2.0
Stk39
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8373,321,522 - 73,588,397 (-)NCBIGRCr8
mRatBN7.2352,913,583 - 53,179,060 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl352,913,585 - 53,179,060 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx356,307,442 - 56,572,955 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0364,891,008 - 65,156,536 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0362,649,675 - 62,915,802 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0354,359,449 - 54,625,702 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl354,359,451 - 54,625,414 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0360,973,443 - 61,244,306 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4350,249,626 - 50,517,085 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1350,297,966 - 50,413,457 (-)NCBI
Celera352,482,845 - 52,746,814 (-)NCBICelera
Cytogenetic Map3q21NCBI
Stk39
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554496,167,752 - 6,390,736 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554496,112,726 - 6,387,925 (+)NCBIChiLan1.0ChiLan1.0
STK39
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21370,588,939 - 70,885,297 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B70,603,916 - 70,900,274 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B55,204,203 - 55,501,033 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B172,674,514 - 172,904,723 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B172,674,514 - 172,970,063 (-)Ensemblpanpan1.1panPan2
STK39
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13612,866,867 - 13,118,736 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3612,867,188 - 13,183,160 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3612,875,995 - 13,167,194 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03612,983,192 - 13,273,757 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3612,913,021 - 13,297,691 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13613,068,051 - 13,358,464 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03613,054,289 - 13,344,871 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03613,165,580 - 13,457,184 (-)NCBIUU_Cfam_GSD_1.0
Stk39
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303130,101,476 - 130,374,107 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646911,274,409 - 11,516,752 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646911,274,398 - 11,516,244 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STK39
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1574,447,787 - 74,758,122 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11574,441,019 - 74,757,851 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21583,412,068 - 83,666,888 (-)NCBISscrofa10.2Sscrofa10.2susScr3
STK39
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11053,451,035 - 53,747,847 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1053,450,891 - 53,682,993 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040145,776,885 - 146,078,123 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stk39
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247875,681,928 - 5,966,699 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247875,682,023 - 5,966,770 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Stk39
15897 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1174
Count of miRNA genes:535
Interacting mature miRNAs:609
Transcripts:ENSMUST00000102715, ENSMUST00000123781, ENSMUST00000126663, ENSMUST00000130380, ENSMUST00000134442, ENSMUST00000139407, ENSMUST00000144457, ENSMUST00000149581
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13464141Hbbcq3_mhemoglobin concentration QTL 3 (mouse)25244801986448136Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)261830344136841920Mouse
1301402Ap2q_malcohol preference 2 QTL (mouse)Not determined24352061277520756Mouse
4142133Pbwg1.6_mpostnatal body weight growth 1.6 (mouse)Not determined3579732469797406Mouse
1300761Lgth1_mbody length 1 (mouse)Not determined25170327685703425Mouse
4141236Hbnr5_mHeligmosomoides bakeri nematode resistance 5 (mouse)Not determined31214567105143570Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
1301405Etohr_methanol response acute (mouse)Not determined26300595497006113Mouse
1301660Iba1_minduction of brown adipocytes 1 (mouse)Not determined267647887101648142Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1300875Taste1_mtaste-saccharin preference 1 (mouse)Not determined25092317584923278Mouse
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357577Trmq3_mT cell ratio modifier QTL 3 (mouse)Not determined260520612119355518Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
13432174Actres5_mactivity response to ethanol/saline 5 (mouse)25989228769792287Mouse
1300662Etohila_methanol induced locomotor activity (mouse)Not determined26300595497006113Mouse
1300788Cia2_mcollagen induced arthritis QTL 2 (mouse)Not determined24352061277520756Mouse
10053681Lith24_mlithogenic gene 24 (mouse)Not determined26300595497006113Mouse
1301048Actre2_mactivity response to ethanol 2 (mouse)Not determined26300595497006113Mouse
1300671Cia4_mcollagen induced arthritis QTL 4 (mouse)Not determined24352061277520756Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
1301411Pitm1_mprion incubation time 1 (mouse)Not determined24352061277520756Mouse
4141069Pbwg1.5_mpostnatal body weight growth 1.5 (mouse)Not determined4352061277520756Mouse
1558820Moo1_mmodifier of Odc1 (mouse)Not determined174826974682269934Mouse
13432184Actdes1_mactivity chamber total difference ethanol/saline 1 (mouse)25939228769292287Mouse
13506939Pbwg1.12_mpostnatal body weight growth 1.12 (mouse)26513241268703425Mouse
4141186Pbwg1.8_mpostnatal body weight growth 1.8 (mouse)Not determined3579732469797406Mouse
13432178Actres2_mactivity response to ethanol/saline 2 (mouse)26069228774092287Mouse
12738429Lfibq18_mliver fibrosis QTL 18 (mouse)25791999191919991Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
11038703Ltpr1_mLeishmania tropica response 1 (mouse)23997166573971811Mouse
1300568Hdl1_mhigh density lipoprotein (HDL) level 1 (mouse)Not determined24826974682269934Mouse
1559001Eae33_mexperimental allergic encephalomyelitis susceptibility 33 (mouse)Not determined23599167971609412Mouse
4142447Pbwg1.7_mpostnatal body weight growth 1.7 (mouse)Not determined3579732469797406Mouse
1301059Hrtfm1_mheart failure modifier 1 (mouse)Not determined26759194074964933Mouse
1301703Bomd3_mbone mineral density 3 (mouse)Not determined26300595497006113Mouse
1301747Eae21_mexperimental allergic encephalomyelitis 21 (mouse)Not determined24826974682269934Mouse
1301235Alcw4_malcohol withdrawal 4 (mouse)Not determined24826974682269934Mouse
4141406Alpq2_malcohol preference QTL 2 (mouse)Not determined25752411791524288Mouse
10755526Lymph1_mlymphocyte differential 1 (mouse)25081931484819314Mouse
13463471Hctq6_mhematocrit QTL 6 (mouse)25244801986448136Mouse
1301873Hsl1_mhyperoxia susceptibility locus 1 (mouse)Not determined26357015497570301Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1301109Dntcs2_mdental caries susceptibility 2 (mouse)Not determined240885493114910165Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
10755532Lymph5_mlymphocyte differential 5 (mouse)24419901778199017Mouse
11532740Pbwg1.10_mpostnatal body weight growth 1.10 (mouse)24813241282132495Mouse
1300577Capsq1_mcapsaicin sensitivity related QTL 1 (mouse)Not determined22760206084013384Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245347635145312647Mouse
13463482Mchq17_mmean corpuscular hemoglobin QTL 17 (mouse)267647887101648142Mouse
1301480Pbwg1_mpostnatal body weight growth 1 (mouse)Not determined24182071975820843Mouse
10044002Hdl7_mHDL level 7 (mouse)Not determined26300595497006113Mouse

Markers in Region
AW227544  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38268,210,640 - 68,210,789UniSTSGRCm38
MGSCv37268,048,697 - 68,048,846UniSTSGRCm37
Celera269,878,800 - 69,878,949UniSTS
Cytogenetic Map2C3UniSTS
Whitehead/MRC_RH21074.0UniSTS
AW556857  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38268,210,956 - 68,211,069UniSTSGRCm38
MGSCv37268,049,013 - 68,049,126UniSTSGRCm37
Celera269,879,116 - 69,879,229UniSTS
Cytogenetic Map2C3UniSTS
Whitehead/MRC_RH21071.54UniSTS
BE107798  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38268,454,430 - 68,454,648UniSTSGRCm38
MGSCv37268,292,487 - 68,292,705UniSTSGRCm37
Celera270,123,235 - 70,123,453UniSTS
Cytogenetic Map2C3UniSTS
UniSTS:225172  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38268,289,957 - 68,290,112UniSTSGRCm38
MGSCv37268,128,014 - 68,128,169UniSTSGRCm37
Cytogenetic Map2C3UniSTS
Stk39  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2C3UniSTS
cM Map239.53UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001412544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001412545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001412546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001412547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001421480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001421481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_016866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_178213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017319128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017319129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017319130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030251878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001783147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001783322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001783323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003953672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF099988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK017292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK132016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL844841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL845486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC051964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC064443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX936296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF410085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JN368425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000102715   ⟹   ENSMUSP00000099776
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl268,040,789 - 68,302,612 (-)Ensembl
GRCm38.p6 Ensembl268,210,445 - 68,472,268 (-)Ensembl
Ensembl Acc Id: ENSMUST00000123781
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl268,093,135 - 68,302,284 (-)Ensembl
GRCm38.p6 Ensembl268,262,791 - 68,471,940 (-)Ensembl
Ensembl Acc Id: ENSMUST00000126663
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl268,040,792 - 68,196,863 (-)Ensembl
GRCm38.p6 Ensembl268,210,448 - 68,366,519 (-)Ensembl
Ensembl Acc Id: ENSMUST00000130380
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl268,042,084 - 68,053,670 (-)Ensembl
GRCm38.p6 Ensembl268,211,740 - 68,223,326 (-)Ensembl
Ensembl Acc Id: ENSMUST00000134442
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl268,042,084 - 68,081,695 (-)Ensembl
GRCm38.p6 Ensembl268,211,740 - 68,251,351 (-)Ensembl
Ensembl Acc Id: ENSMUST00000139407
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl268,042,091 - 68,081,673 (-)Ensembl
GRCm38.p6 Ensembl268,211,747 - 68,251,329 (-)Ensembl
Ensembl Acc Id: ENSMUST00000144457
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl268,042,084 - 68,081,700 (-)Ensembl
GRCm38.p6 Ensembl268,211,740 - 68,251,356 (-)Ensembl
Ensembl Acc Id: ENSMUST00000149581
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl268,189,330 - 68,217,025 (-)Ensembl
GRCm38.p6 Ensembl268,358,986 - 68,386,681 (-)Ensembl
RefSeq Acc Id: NM_001412544   ⟹   NP_001399473
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39268,079,231 - 68,302,381 (-)NCBI
RefSeq Acc Id: NM_001412545   ⟹   NP_001399474
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39268,040,791 - 68,302,381 (-)NCBI
RefSeq Acc Id: NM_001412546   ⟹   NP_001399475
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39268,040,791 - 68,298,914 (-)NCBI
RefSeq Acc Id: NM_001412547   ⟹   NP_001399476
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39268,040,791 - 68,298,914 (-)NCBI
RefSeq Acc Id: NM_001421480   ⟹   NP_001408409
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39268,093,439 - 68,302,381 (-)NCBI
RefSeq Acc Id: NM_001421481   ⟹   NP_001408410
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39268,040,791 - 68,081,697 (-)NCBI
RefSeq Acc Id: NM_016866   ⟹   NP_058562
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39268,040,791 - 68,302,381 (-)NCBI
GRCm38268,210,447 - 68,471,981 (-)NCBI
MGSCv37268,048,504 - 68,310,038 (-)RGD
Celera269,878,607 - 70,140,879 (-)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_178213
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39268,040,791 - 68,302,381 (-)NCBI
RefSeq Acc Id: XM_017319128   ⟹   XP_017174617
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39268,040,789 - 68,243,828 (-)NCBI
GRCm38268,210,445 - 68,413,484 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017319129   ⟹   XP_017174618
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39268,040,789 - 68,243,828 (-)NCBI
GRCm38268,210,445 - 68,413,484 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017319130   ⟹   XP_017174619
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39268,040,789 - 68,246,133 (-)NCBI
GRCm38268,210,777 - 68,415,789 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030251878   ⟹   XP_030107738
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39268,040,789 - 68,208,721 (-)NCBI
GRCm38268,210,445 - 68,378,324 (-)NCBI
Sequence:
RefSeq Acc Id: XR_001783147
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39268,040,789 - 68,243,828 (-)NCBI
GRCm38268,210,445 - 68,413,484 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003953672
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39268,040,789 - 68,243,828 (-)NCBI
GRCm38268,210,445 - 68,413,484 (-)NCBI
Sequence:
RefSeq Acc Id: NP_058562   ⟸   NM_016866
- Peptide Label: isoform 1
- UniProtKB: Q9Z1W9 (UniProtKB/Swiss-Prot),   Q80W13 (UniProtKB/Swiss-Prot),   A2AQL0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017174618   ⟸   XM_017319129
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017174617   ⟸   XM_017319128
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017174619   ⟸   XM_017319130
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_030107738   ⟸   XM_030251878
- Peptide Label: isoform X5
- UniProtKB: G1JLS7 (UniProtKB/TrEMBL),   Q3V256 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000099776   ⟸   ENSMUST00000102715
RefSeq Acc Id: NP_001399474   ⟸   NM_001412545
- Peptide Label: isoform 3
RefSeq Acc Id: NP_001399476   ⟸   NM_001412547
- Peptide Label: isoform 5
RefSeq Acc Id: NP_001399475   ⟸   NM_001412546
- Peptide Label: isoform 4
RefSeq Acc Id: NP_001399473   ⟸   NM_001412544
- Peptide Label: isoform 2
RefSeq Acc Id: NP_001408410   ⟸   NM_001421481
- Peptide Label: isoform 7
RefSeq Acc Id: NP_001408409   ⟸   NM_001421480
- Peptide Label: isoform 6
Protein Domains
Protein kinase   Serine/threonine-protein kinase OSR1/WNK CCT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z1W9-F1-model_v2 AlphaFold Q9Z1W9 1-556 view protein structure

Promoters
RGD ID:6832872
Promoter ID:MM_KWN:29513
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000031249
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36268,224,141 - 68,224,641 (-)MPROMDB
RGD ID:6832877
Promoter ID:MM_KWN:29514
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000031247,   UC008JXP.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36268,309,716 - 68,310,216 (-)MPROMDB
RGD ID:6877478
Promoter ID:EPDNEW_M2189
Type:initiation region
Name:Stk39_2
Description:Mus musculus serine/threonine kinase 39 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M2190  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38268,366,533 - 68,366,593EPDNEW
RGD ID:6877480
Promoter ID:EPDNEW_M2190
Type:initiation region
Name:Stk39_1
Description:Mus musculus serine/threonine kinase 39 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M2189  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38268,472,022 - 68,472,082EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1858416 AgrOrtholog
Ensembl Genes ENSMUSG00000027030 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000102715 ENTREZGENE
  ENSMUST00000102715.4 UniProtKB/Swiss-Prot
  ENSMUST00000123781 ENTREZGENE
Gene3D-CATH Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase_OSR1/WNK_CCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STE20/SPS1-PAK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:53416 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1858416 ENTREZGENE
NCBI Gene Stk39 ENTREZGENE
PANTHER STE20/SPS1-RELATED PROLINE-ALANINE-RICH PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STERILE20-LIKE KINASE, ISOFORM B-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam OSR1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Stk39 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2AQL0 ENTREZGENE, UniProtKB/TrEMBL
  G1JLS7 ENTREZGENE, UniProtKB/TrEMBL
  Q3TR01_MOUSE UniProtKB/TrEMBL
  Q3V256 ENTREZGENE, UniProtKB/TrEMBL
  Q80W13 ENTREZGENE
  Q9Z1W9 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q80W13 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-26 Stk39  serine/threonine kinase 39  Spak-pending  Ste-20 related kinase  Symbol and/or name updated 27372883 PROVISIONAL
2024-08-21 Spak-pending  Ste-20 related kinase  Stk39  serine/threonine kinase 39  Symbol and/or name change 5135510 APPROVED
2023-05-25 Stk39  serine/threonine kinase 39  Gm50618  predicted gene, 50618  Data merged from RGD:39129326 737654 PROVISIONAL
2020-11-24 Gm50618  predicted gene, 50618  LOC108168764  uncharacterized LOC108168764  Symbol and/or name change 5135510 APPROVED
2012-07-05 Stk39  serine/threonine kinase 39  Stk39  serine/threonine kinase 39, STE20/SPS1 homolog (yeast)  Symbol and/or name change 5135510 APPROVED