Aldh1a2 (aldehyde dehydrogenase family 1, subfamily A2) - Rat Genome Database

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Gene: Aldh1a2 (aldehyde dehydrogenase family 1, subfamily A2) Mus musculus
Analyze
Symbol: Aldh1a2
Name: aldehyde dehydrogenase family 1, subfamily A2
RGD ID: 734164
MGI Page MGI
Description: Enables 3-chloroallyl aldehyde dehydrogenase activity and retinal dehydrogenase activity. Involved in cellular response to retinoic acid. Acts upstream of or within several processes, including circulatory system development; nervous system development; and retinoid metabolic process. Predicted to be located in perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study DiGeorge syndrome. Human ortholog(s) of this gene implicated in congenital diaphragmatic hernia. Orthologous to human ALDH1A2 (aldehyde dehydrogenase 1 family member A2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alcohol dehydrogenase family 1, subfamily A2; alcohol dehydrogenase family 1, subfamily A7; aldehyde dehydrogenase family 1 member A2; Aldh; Aldh1a7; AV116159; Ral; RALDH 2; RALDH(II); Raldh1; Raldh2; retinal dehydrogenase 2; retinaldehyde dehydrogenase 2; retinaldehyde-specific dehydrogenase type 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39971,123,071 - 71,203,525 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl971,123,071 - 71,203,525 (+)EnsemblGRCm39 Ensembl
GRCm38971,215,789 - 71,296,243 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl971,215,789 - 71,296,243 (+)EnsemblGRCm38mm10GRCm38
MGSCv37971,063,596 - 71,144,050 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36971,014,409 - 71,094,803 (+)NCBIMGSCv36mm8
Celera968,414,967 - 68,495,534 (+)NCBICelera
Cytogenetic Map9DNCBI
cM Map939.85NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-Ethylhexanoic acid  (EXP)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
22-Hydroxycholesterol  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-(diethylamino)benzaldehyde  (ISO)
4-[3-(4-tert-butylphenyl)-2-methylpropyl]-2,6-dimethylmorpholine  (EXP)
4-hydroperoxycyclophosphamide  (ISO)
4-nitrophenol  (EXP)
6-propyl-2-thiouracil  (ISO)
abacavir  (ISO)
acetaldehyde  (EXP)
aflatoxin B1  (ISO)
all-trans-retinal  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP)
ammonium chloride  (ISO)
arsenite(3-)  (EXP,ISO)
benzaldehydes  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (EXP)
bezafibrate  (EXP)
bictegravir  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
butylated hydroxyanisole  (EXP)
butyric acid  (ISO)
cadmium atom  (EXP)
carbon nanotube  (EXP)
CGP 52608  (ISO)
CHIR 99021  (ISO)
chloroprene  (ISO)
choline  (ISO)
citral  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cylindrospermopsin  (ISO)
D-gluconic acid  (ISO)
dabigatran  (ISO)
daidzein  (ISO)
daidzein 7-O-beta-D-glucoside  (ISO)
decanal  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
diquat  (EXP)
disulfiram  (ISO)
dolutegravir  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Doxylamine succinate  (ISO)
elvitegravir  (EXP)
entinostat  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP)
ethylene glycol  (ISO)
ethylparaben  (ISO)
fenofibrate  (EXP)
fenpropidin  (EXP)
ferric oxide  (ISO)
fulvestrant  (ISO)
furan  (ISO)
genistein  (ISO)
genistein 7-O-beta-D-glucoside  (ISO)
gentamycin  (ISO)
geranial  (ISO)
glycitein  (ISO)
glycitin  (ISO)
hexanal  (ISO)
Indeno[1,2,3-cd]pyrene  (EXP)
indirubin-3'-monoxime  (EXP)
indole-3-methanol  (EXP)
isotretinoin  (ISO)
lipopolysaccharide  (EXP,ISO)
methamphetamine  (ISO)
methoxyacetic acid  (EXP)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
methylparaben  (EXP)
metoclopramide  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nilotinib  (ISO)
nitrofen  (ISO)
ochratoxin A  (ISO)
ozone  (EXP,ISO)
panobinostat  (ISO)
paraquat  (ISO)
phenethyl caffeate  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
pirinixic acid  (EXP)
pravastatin  (EXP)
progesterone  (EXP)
rac-lactic acid  (ISO)
resveratrol  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sotorasib  (ISO)
spiroxamine  (EXP)
thalidomide  (ISO)
thapsigargin  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trametinib  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
WIN 18446  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
9-cis-retinoic acid biosynthetic process  (IDA)
anterior/posterior pattern specification  (IGI,IMP)
blood vessel development  (IMP)
camera-type eye development  (IMP)
cardiac muscle tissue development  (IMP)
cell population proliferation  (IMP)
cellular response to retinoic acid  (IEP)
determination of bilateral symmetry  (IMP)
embryonic camera-type eye development  (IGI)
embryonic digestive tract development  (IMP)
embryonic forelimb morphogenesis  (IMP)
embryonic limb morphogenesis  (IMP)
face development  (IGI,IMP)
forebrain development  (IMP)
heart development  (TAS)
heart looping  (TAS)
heart morphogenesis  (IMP)
hindbrain development  (IMP)
kidney development  (IEA,ISO)
liver development  (IEA,ISO)
lung development  (IMP)
midgut development  (IEA,ISO)
morphogenesis of embryonic epithelium  (IMP)
negative regulation of cell population proliferation  (IEA,ISO)
neural crest cell development  (IGI,IMP)
neural tube development  (IEA,ISO)
neuron differentiation  (IMP)
pancreas development  (IMP)
pituitary gland development  (IEA,ISO)
positive regulation of apoptotic process  (IMP)
positive regulation of cell population proliferation  (IMP)
positive regulation of gene expression  (IMP)
protein homotetramerization  (ISO,ISS)
proximal/distal pattern formation  (IMP)
regulation of vascular endothelial cell proliferation  (IMP)
response to cytokine  (IEA,ISO)
response to estradiol  (IEA,ISO)
response to retinoic acid  (ISO,ISS)
response to vitamin A  (IEA,ISO)
retinal metabolic process  (IDA)
retinoic acid biosynthetic process  (ISO)
retinoic acid metabolic process  (IDA,IMP,ISO)
retinoic acid receptor signaling pathway  (IGI,IMP)
retinoid metabolic process  (TAS)
retinol metabolic process  (IEA)
ureter maturation  (IMP)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
aberrant origin of the right subclavian artery  (IAGP)
abnormal aortic arch and aortic arch branch attachment  (IAGP)
abnormal artery morphology  (IAGP)
abnormal common carotid artery morphology  (IAGP)
abnormal cranial nerve morphology  (IAGP)
abnormal cricoid cartilage morphology  (IAGP)
abnormal digit morphology  (IAGP)
abnormal embryo turning  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal fetal atrioventricular canal morphology  (IAGP)
abnormal fetal cardiomyocyte morphology  (IAGP)
abnormal first pharyngeal arch morphology  (IAGP)
abnormal glossopharyngeal ganglion morphology  (IAGP)
abnormal head mesenchyme morphology  (IAGP)
abnormal heart development  (IAGP)
abnormal heart tube morphology  (IAGP)
abnormal laryngeal cartilage morphology  (IAGP)
abnormal left subclavian artery morphology  (IAGP)
abnormal mandibular prominence morphology  (IAGP)
abnormal maxillary prominence morphology  (IAGP)
abnormal motor neuron innervation pattern  (IAGP)
abnormal myocardium layer morphology  (IAGP)
abnormal nervous system development  (IAGP)
abnormal neural crest cell migration  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal optic cup morphology  (IAGP)
abnormal otic vesicle morphology  (IAGP)
abnormal pharyngeal arch artery morphology  (IAGP)
abnormal pharyngeal arch morphology  (IAGP)
abnormal pharyngeal pouch morphology  (IAGP)
abnormal somite development  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal third pharyngeal arch artery morphology  (IAGP)
abnormal thyroid cartilage morphology  (IAGP)
abnormal tracheal cartilage morphology  (IAGP)
abnormal trigeminal ganglion morphology  (IAGP)
abnormal truncus arteriosus septation  (IAGP)
abnormal vagus ganglion morphology  (IAGP)
abnormal vascular development  (IAGP)
abnormal vestibulocochlear ganglion morphology  (IAGP)
abnormal vitamin A level  (IAGP)
abnormal vitamin A metabolism  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
absent atrioventricular cushions  (IAGP)
absent forelimb buds  (IAGP)
absent fourth pharyngeal arch  (IAGP)
absent hindlimb buds  (IAGP)
absent myocardial trabeculae  (IAGP)
absent parathyroid glands  (IAGP)
absent pharyngeal arch arteries  (IAGP)
absent pharyngeal arches  (IAGP)
absent second pharyngeal arch  (IAGP)
absent third pharyngeal arch  (IAGP)
absent Wolffian ducts  (IAGP)
athymia  (IAGP)
azoospermia  (IAGP)
caudal body truncation  (IAGP)
cervical aortic arch  (IAGP)
conotruncal ridge hypoplasia  (IAGP)
cyanosis  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased embryo size  (IAGP)
decreased motor neuron number  (IAGP)
decreased Sertoli cell number  (IAGP)
decreased somite size  (IAGP)
decreased tracheal cartilage ring number  (IAGP)
double aortic arch  (IAGP)
embryonic growth arrest  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged heart  (IAGP)
failure of heart looping  (IAGP)
failure of ventral body wall closure  (IAGP)
fusion of glossopharyngeal and vagus nerve  (IAGP)
impaired branching involved in ureteric bud morphogenesis  (IAGP)
incomplete caudal neuropore closure  (IAGP)
male infertility  (IAGP)
no abnormal phenotype detected  (IAGP)
otic vesicle hypoplasia  (IAGP)
persistent truncus arteriosus  (IAGP)
pharyngeal arch hypoplasia  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
renal hypoplasia  (IAGP)
right aortic arch  (IAGP)
short trachea  (IAGP)
small first pharyngeal arch  (IAGP)
small forelimb buds  (IAGP)
small frontonasal prominence  (IAGP)
small otic vesicle  (IAGP)
syndactyly  (IAGP)
thick myocardium  (IAGP)
thymus hypoplasia  (IAGP)
ventricular septal defect  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Upregulation of retinal dehydrogenase 2 in alternatively activated macrophages during retinoid-dependent type-2 immunity to helminth infection in mice. Broadhurst MJ, etal., PLoS Pathog. 2012;8(8):e1002883. doi: 10.1371/journal.ppat.1002883. Epub 2012 Aug 23.
2. Immunolocalization of retinoic acid biosynthesis systems in selected sites in rat. Everts HB, etal., Exp Cell Res. 2005 Aug 15;308(2):309-19.
3. Mitochondrial Aldehyde Dehydrogenase 2 Regulates Revascularization in Chronic Ischemia: Potential Impact on the Development of Coronary Collateral Circulation. Liu X, etal., Arterioscler Thromb Vasc Biol. 2015 Oct;35(10):2196-206. doi: 10.1161/ATVBAHA.115.306012. Epub 2015 Aug 27.
4. Retinal dehydrogenase-2 is inhibited by compounds that induce congenital diaphragmatic hernias in rodents. Mey J, etal., Am J Pathol. 2003 Feb;162(2):673-9.
5. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. MGD IEA MGD IEA
8. Novel retinoic acid generating activities in the neural tube and heart identified by conditional rescue of Raldh2 null mutant mice. Mic FA, etal., Development. 2002 May;129(9):2271-82.
9. Physiological insights into all-trans-retinoic acid biosynthesis. Napoli JL Biochim Biophys Acta. 2012 Jan;1821(1):152-67. Epub 2011 May 19.
10. Retinaldehyde dehydrogenase 2 is down-regulated during duodenal atresia formation in Fgfr2IIIb-/- mice. Nichol PF, etal., J Surg Res. 2012 Jun 1;175(1):82-7. doi: 10.1016/j.jss.2011.02.040. Epub 2011 Mar 21.
11. Embryonic retinoic acid synthesis is essential for heart morphogenesis in the mouse. Niederreither K, etal., Development. 2001 Apr;128(7):1019-31.
12. Embryonic retinoic acid synthesis is essential for early mouse post-implantation development. Niederreither K, etal., Nat Genet. 1999 Apr;21(4):444-8.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
15. Haploinsufficiency of retinaldehyde dehydrogenase 2 decreases the severity and incidence of duodenal atresia in the fibroblast growth factor receptor 2IIIb-/- mouse model. Reeder AL, etal., Surgery. 2012 Oct;152(4):768-75; discussion 775-6. doi: 10.1016/j.surg.2012.07.022.
16. Mouse MP Annotation Import Pipeline RGD automated import pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Retinaldehyde dehydrogenase 2 and Hoxc8 are required in the murine brachial spinal cord for the specification of Lim1+ motoneurons and the correct distribution of Islet1+ motoneurons. Vermot J, etal., Development. 2005 Apr;132(7):1611-21.
20. Decreased embryonic retinoic acid synthesis results in a DiGeorge syndrome phenotype in newborn mice. Vermot J, etal., Proc Natl Acad Sci U S A 2003 Feb 18;100(4):1763-8. Epub 2003 Jan 31.
21. Multiple retinol and retinal dehydrogenases catalyze all-trans-retinoic acid biosynthesis in astrocytes. Wang C, etal., J Biol Chem. 2011 Feb 25;286(8):6542-53. Epub 2010 Dec 7.
Additional References at PubMed
PMID:8393814   PMID:8797830   PMID:9022057   PMID:9106168   PMID:9676192   PMID:9819382   PMID:9826179   PMID:9892670   PMID:10192377   PMID:10204534   PMID:10331979   PMID:10349636  
PMID:10482234   PMID:10570467   PMID:10588879   PMID:10654602   PMID:10753524   PMID:10837133   PMID:10858567   PMID:10862743   PMID:10864957   PMID:10892744   PMID:10906479   PMID:10922068  
PMID:11025231   PMID:11042159   PMID:11076861   PMID:11134352   PMID:11138002   PMID:11144352   PMID:11217851   PMID:11231062   PMID:11386761   PMID:11472854   PMID:11562352   PMID:11688558  
PMID:11744377   PMID:11744378   PMID:11747070   PMID:11749040   PMID:11795391   PMID:11876656   PMID:11923206   PMID:11953746   PMID:12050134   PMID:12117807   PMID:12360493   PMID:12454286  
PMID:12466851   PMID:12477932   PMID:12588859   PMID:12610736   PMID:12702665   PMID:12782789   PMID:12808103   PMID:12930800   PMID:13129847   PMID:14550786   PMID:14623241   PMID:14627725  
PMID:14681479   PMID:15030763   PMID:15053971   PMID:15069081   PMID:15161092   PMID:15172686   PMID:15175265   PMID:15240886   PMID:15242798   PMID:15245423   PMID:15299009   PMID:15328022  
PMID:15342483   PMID:15366004   PMID:15380252   PMID:15489334   PMID:15634693   PMID:15634700   PMID:15652703   PMID:15731404   PMID:15739227   PMID:15765518   PMID:15766748   PMID:15843414  
PMID:15872003   PMID:15889094   PMID:15944189   PMID:16026781   PMID:16109395   PMID:16127714   PMID:16141072   PMID:16141073   PMID:16186816   PMID:16193510   PMID:16207763   PMID:16322559  
PMID:16364899   PMID:16368932   PMID:16399080   PMID:16427040   PMID:16470614   PMID:16489341   PMID:16496350   PMID:16511601   PMID:16574820   PMID:16600854   PMID:16602821   PMID:16611695  
PMID:16615129   PMID:16781703   PMID:16790475   PMID:16806149   PMID:16818722   PMID:16942767   PMID:16979153   PMID:17036046   PMID:17067568   PMID:17126317   PMID:17131407   PMID:17172448  
PMID:17184764   PMID:17207476   PMID:17270348   PMID:17332066   PMID:18028902   PMID:18065432   PMID:18093970   PMID:18157121   PMID:18287057   PMID:18287559   PMID:18328475   PMID:18331719  
PMID:18393306   PMID:18399539   PMID:18478160   PMID:18498088   PMID:18561907   PMID:18590716   PMID:18662545   PMID:18665267   PMID:18684862   PMID:18723448   PMID:18776146   PMID:18816858  
PMID:18971422   PMID:18973680   PMID:18992716   PMID:19075394   PMID:19168680   PMID:19273610   PMID:19411759   PMID:19448158   PMID:19464179   PMID:19519663   PMID:19521566   PMID:19539783  
PMID:19549509   PMID:19605690   PMID:19621436   PMID:19737349   PMID:19783990   PMID:19853565   PMID:19854269   PMID:19879845   PMID:19906845   PMID:20034106   PMID:20040494   PMID:20081195  
PMID:20110314   PMID:20110535   PMID:20185795   PMID:20299672   PMID:20439714   PMID:20448247   PMID:20484817   PMID:20589901   PMID:20711475   PMID:20737513   PMID:20801112   PMID:20826310  
PMID:20833146   PMID:20881014   PMID:21035938   PMID:21046629   PMID:21138976   PMID:21205789   PMID:21224842   PMID:21252157   PMID:21305688   PMID:21311046   PMID:21343363   PMID:21364285  
PMID:21385575   PMID:21402589   PMID:21409183   PMID:21436255   PMID:21497760   PMID:21521737   PMID:21532733   PMID:21538808   PMID:21663736   PMID:21750036   PMID:21757651   PMID:21839733  
PMID:21858105   PMID:21873635   PMID:21930923   PMID:22278926   PMID:22279234   PMID:22319578   PMID:22365545   PMID:22387209   PMID:22396766   PMID:22451728   PMID:22535523   PMID:22573622  
PMID:22627279   PMID:22675207   PMID:22819676   PMID:22833126   PMID:22833130   PMID:22911456   PMID:22926762   PMID:22930583   PMID:22954964   PMID:22984617   PMID:23012458   PMID:23077214  
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PMID:23685333   PMID:23763947   PMID:23806210   PMID:23829703   PMID:23833249   PMID:23874217   PMID:23988635   PMID:23993789   PMID:24000064   PMID:24005908   PMID:24074870   PMID:24331925  
PMID:24353058   PMID:24357327   PMID:24361260   PMID:24361262   PMID:24401276   PMID:24699546   PMID:24733397   PMID:24788806   PMID:24821700   PMID:24952961   PMID:24997521   PMID:25053430  
PMID:25139858   PMID:25152336   PMID:25190705   PMID:25209250   PMID:25261715   PMID:25299188   PMID:25577283   PMID:25617432   PMID:25624266   PMID:25753732   PMID:25813538   PMID:25843547  
PMID:25861444   PMID:26235626   PMID:26237517   PMID:26238476   PMID:26243870   PMID:26427057   PMID:26442704   PMID:26446231   PMID:26511275   PMID:26739565   PMID:27253890   PMID:27488639  
PMID:27506116   PMID:27568519   PMID:27642710   PMID:27671872   PMID:27740873   PMID:27793834   PMID:28011626   PMID:28049658   PMID:28087631   PMID:28188179   PMID:28190640   PMID:28274610  
PMID:28324176   PMID:28334964   PMID:28346476   PMID:28363736   PMID:28465335   PMID:28539333   PMID:28655168   PMID:28715412   PMID:28737171   PMID:28779023   PMID:28790015   PMID:29029363  
PMID:29084269   PMID:29093497   PMID:29095919   PMID:29109083   PMID:29217200   PMID:29361518   PMID:29379870   PMID:29391420   PMID:29447006   PMID:29509905   PMID:29708625   PMID:29771958  
PMID:29945868   PMID:29986869   PMID:30016433   PMID:30166332   PMID:30247516   PMID:30254164   PMID:30377232   PMID:30413670   PMID:30478225   PMID:30487180   PMID:30559277   PMID:30578278  
PMID:30615824   PMID:30632787   PMID:30642949   PMID:30649340   PMID:30885956   PMID:30916783   PMID:31028279   PMID:31112136   PMID:31118232   PMID:31118233   PMID:31299141   PMID:31515492  
PMID:31550482   PMID:31659279   PMID:31870435   PMID:31879367   PMID:31913463   PMID:31928974   PMID:31940751   PMID:31969659   PMID:32001436   PMID:32152201   PMID:32169905   PMID:32209473  
PMID:32253237   PMID:32324134   PMID:32325033   PMID:32421711   PMID:32457985   PMID:32494737   PMID:32553152   PMID:32562756   PMID:32634398   PMID:32715478   PMID:32901287   PMID:33201874  
PMID:33298461   PMID:33452727   PMID:33482080   PMID:33560225   PMID:33735101   PMID:33795231   PMID:33822475   PMID:33892704   PMID:34321999   PMID:34368133   PMID:34599305   PMID:34623260  
PMID:34643182   PMID:34994686   PMID:35020897   PMID:35103284   PMID:35177643   PMID:35315776   PMID:35521669   PMID:35574006   PMID:35704566   PMID:35817961   PMID:35905011   PMID:35950911  
PMID:35974052   PMID:36028102   PMID:36094016   PMID:36293499   PMID:36542696   PMID:36575170   PMID:36880532   PMID:36960826   PMID:36994104   PMID:36996816   PMID:37146794   PMID:37160119  
PMID:37414952   PMID:37590085   PMID:37756583   PMID:37756602   PMID:37852253   PMID:38177914   PMID:38183987   PMID:38345319   PMID:38828908  


Genomics

Comparative Map Data
Aldh1a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39971,123,071 - 71,203,525 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl971,123,071 - 71,203,525 (+)EnsemblGRCm39 Ensembl
GRCm38971,215,789 - 71,296,243 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl971,215,789 - 71,296,243 (+)EnsemblGRCm38mm10GRCm38
MGSCv37971,063,596 - 71,144,050 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36971,014,409 - 71,094,803 (+)NCBIMGSCv36mm8
Celera968,414,967 - 68,495,534 (+)NCBICelera
Cytogenetic Map9DNCBI
cM Map939.85NCBI
ALDH1A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381557,953,429 - 58,065,711 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1557,953,424 - 58,497,866 (-)EnsemblGRCh38hg38GRCh38
GRCh371558,245,627 - 58,357,909 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361556,032,919 - 56,145,198 (-)NCBINCBI36Build 36hg18NCBI36
Build 341556,032,918 - 56,093,527NCBI
Celera1535,135,291 - 35,247,470 (-)NCBICelera
Cytogenetic Map15q21.3NCBI
HuRef1535,068,702 - 35,181,099 (-)NCBIHuRef
CHM1_11558,363,582 - 58,476,117 (-)NCBICHM1_1
T2T-CHM13v2.01555,755,851 - 55,868,018 (-)NCBIT2T-CHM13v2.0
Aldh1a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8880,758,641 - 80,837,891 (+)NCBIGRCr8
mRatBN7.2871,877,850 - 71,957,107 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl871,877,850 - 71,957,107 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx877,412,501 - 77,491,856 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0875,685,476 - 75,764,833 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0873,522,516 - 73,601,878 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0877,640,234 - 77,719,488 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl877,640,222 - 77,719,489 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0875,363,285 - 75,442,554 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4875,692,099 - 75,771,159 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1875,711,165 - 75,790,204 (+)NCBI
Celera869,779,737 - 69,858,993 (-)NCBICelera
Cytogenetic Map8q24NCBI
Aldh1a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545016,406,436 - 16,453,180 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545016,406,578 - 16,453,048 (+)NCBIChiLan1.0ChiLan1.0
ALDH1A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21647,196,709 - 47,377,143 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11551,379,387 - 51,559,409 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01536,925,443 - 37,038,288 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11555,237,101 - 55,349,851 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1555,237,101 - 55,557,168 (-)Ensemblpanpan1.1panPan2
ALDH1A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13023,074,432 - 23,170,374 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3023,074,432 - 23,340,030 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3023,045,955 - 23,141,851 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03023,233,206 - 23,329,111 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3023,233,206 - 23,498,331 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13023,164,758 - 23,260,609 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03023,250,334 - 23,346,246 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03023,392,036 - 23,488,058 (-)NCBIUU_Cfam_GSD_1.0
Aldh1a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640101,327,905 - 101,415,451 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647119,175,992 - 19,263,335 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647119,175,997 - 19,263,335 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALDH1A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1113,932,739 - 114,037,046 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11113,932,722 - 114,037,059 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21126,038,541 - 126,105,080 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ALDH1A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12625,439,159 - 25,557,199 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2625,439,360 - 25,557,202 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048115,756,952 - 115,875,731 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aldh1a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478113,756,390 - 13,845,479 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478113,756,469 - 13,845,253 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Aldh1a2
2579 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:251
Count of miRNA genes:188
Interacting mature miRNAs:204
Transcripts:ENSMUST00000034723
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300563Pgia5_mproteoglycan induced arthritis 5 (mouse)Not determined94883105682831177Mouse
1301456Adip5_madiposity 5 (mouse)Not determined95936994693370128Mouse
12790986Pcho9_mplasma cholesterol 9 (mouse)93809957572099575Mouse
12790990Tgl7_mtriglyceride 7 (mouse)95455996088559960Mouse
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93397884073439255Mouse
10412174Habiir4_mhyperoxic acute lung injury imprinted region 4 (mouse)Not determined96926774798701707Mouse
14746993Manh66_mmandible shape 66 (mouse)94981404883814048Mouse
1301184Bdln4_mbody length 4 (mouse)Not determined95015132084151448Mouse
4141676Neogq1_mneonatal growth QTL 1 (mouse)Not determined95780504786121973Mouse
12790992Arlsq1_maortic root lesion size QTL 1 (mouse)93809957572099575Mouse
12738449Spcq2_msperm count QTL 2 (mouse)93939988573399885Mouse
1301702Brm1_mbrachyury modifier 1 (mouse)Not determined94080504774805204Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63239711120191934Mouse
1301636Lith5_mlithogenic gene 5 (mouse)Not determined966089077100089175Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963239711120191934Mouse
4141224Dxmod_mdoxorubicin nephropathy modifier (mouse)Not determined49452421101406120Mouse
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959897283109089068Mouse
12791002Arlsq2_maortic root lesion size QTL 2 (mouse)93809957572099575Mouse
10043971Obq32_mobesity QTL 32 (mouse)Not determined93781952871819528Mouse
10045639Heal28_mwound healing/regeneration 28 (mouse)Not determined94348071477480860Mouse
10045638Heal29_mwound healing/regeneration 29 (mouse)Not determined967006220101006220Mouse
1300848Skull13_mskull morphology 13 (mouse)Not determined95936994693370128Mouse
11081165Psl6_mpromotion susceptibility QTL 6 (mouse)96504119195522808Mouse
1301558Stheal8_msoft tissue heal 8 (mouse)Not determined94348071477480860Mouse
1301302Pas4_mpulmonary adenoma susceptibility 4 (mouse)Not determined969121898103121973Mouse
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93730619798701707Mouse
1301621Hpic1_mhaloperidol-induced catalepsy 1 (mouse)Not determined969428566103428698Mouse
1301172Fembrs6_mfemur breaking strength 6 (mouse)Not determined95902438793024534Mouse
1301435Trigq1_mtriglyceride QTL 1 (mouse)Not determined94442817478428262Mouse
5491195Mobq8_mmultigenic obesity QTL 8 (mouse)Not determined95936994693370128Mouse
1301241Renf1_mrenal failure 1 (mouse)Not determined95203447899792481Mouse
4141071Ath29_matherosclerosis 29 (mouse)Not determined94041959474607925Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63239711120191934Mouse
1301924Bmd10_mbone mineral density 10 (mouse)Not determined968779563102779705Mouse
1301611Lrnx3_mlearning contextual 3 (mouse)Not determined96214976796149881Mouse
1301803Stheal9_msoft tissue heal 9 (mouse)Not determined95902438793024534Mouse
1301290Smgd1_msubmucosal gland distribution 1 (mouse)Not determined96583105686577967Mouse
10043877Adip21_madiposity 21 (mouse)Not determined95643910890439255Mouse
1301549Bbaa9_mB.burgdorferi-associated arthritis 9 (mouse)Not determined95780504771481754Mouse
1357610Vtbt8_mvertebral trabecular bone trait 8 (mouse)Not determined968779563102779705Mouse
1300716Cd4ts4_mCD4 T cell subset 4 (mouse)Not determined94883105682831177Mouse

Markers in Region
Aldh1a2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9DUniSTS
cM Map942.0UniSTS
cM Map942.0UniSTS
AV116159  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38971,296,058 - 71,296,138UniSTSGRCm38
MGSCv37971,143,865 - 71,143,945UniSTSGRCm37
Celera968,495,349 - 68,495,429UniSTS
Cytogenetic Map9DUniSTS
cM Map942.0UniSTS
Whitehead/MRC_RH9688.16UniSTS
X99273  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38971,295,647 - 71,295,748UniSTSGRCm38
MGSCv37971,143,454 - 71,143,555UniSTSGRCm37
Celera968,494,938 - 68,495,039UniSTS
Cytogenetic Map9DUniSTS
cM Map942.0UniSTS
Whitehead/MRC_RH9688.12UniSTS
Whitehead_YAC9 UniSTS
Aldh1a2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9DUniSTS
Aldh1a2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9DUniSTS
cM Map942.0UniSTS
Aldh1a2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9DUniSTS
Aldh1a2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9DUniSTS
Aldh1a2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9DUniSTS
X99273  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9DUniSTS
Whitehead/MRC_RH9688.12UniSTS
Aldh1a2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9DUniSTS
cM Map942.0UniSTS
Aldh1a2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9DUniSTS
Aldh1a2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9DUniSTS
Aldh1a2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9DUniSTS
cM Map942.0UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000034723   ⟹   ENSMUSP00000034723
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl971,123,071 - 71,203,525 (+)Ensembl
GRCm38.p6 Ensembl971,215,789 - 71,296,243 (+)Ensembl
RefSeq Acc Id: NM_009022   ⟹   NP_033048
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39971,123,071 - 71,203,525 (+)NCBI
GRCm38971,215,789 - 71,296,243 (+)ENTREZGENE
MGSCv37971,063,596 - 71,144,050 (+)RGD
Celera968,414,967 - 68,495,534 (+)RGD
cM Map9 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_033048 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH75704 (Get FASTA)   NCBI Sequence Viewer  
  AAK64273 (Get FASTA)   NCBI Sequence Viewer  
  BAC37332 (Get FASTA)   NCBI Sequence Viewer  
  CAA67666 (Get FASTA)   NCBI Sequence Viewer  
  EDL26223 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000034723
  ENSMUSP00000034723.6
GenBank Protein Q62148 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_033048   ⟸   NM_009022
- UniProtKB: Q6DI79 (UniProtKB/Swiss-Prot),   Q62148 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000034723   ⟸   ENSMUST00000034723

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62148-F1-model_v2 AlphaFold Q62148 1-518 view protein structure

Promoters
RGD ID:8670116
Promoter ID:EPDNEW_M13088
Type:multiple initiation site
Name:Aldh1a2_1
Description:Mus musculus aldehyde dehydrogenase family 1, subfamily A2 ,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38971,215,815 - 71,215,875EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107928 AgrOrtholog
Ensembl Genes ENSMUSG00000013584 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000034723 ENTREZGENE
  ENSMUST00000034723.6 UniProtKB/Swiss-Prot
InterPro Ald_DH/histidinol_DH UniProtKB/Swiss-Prot
  Ald_DH_C UniProtKB/Swiss-Prot
  Ald_DH_CS_CYS UniProtKB/Swiss-Prot
  Ald_DH_CS_GLU UniProtKB/Swiss-Prot
  Ald_DH_N UniProtKB/Swiss-Prot
  Aldehyde_DH_dom UniProtKB/Swiss-Prot
KEGG Report mmu:19378 UniProtKB/Swiss-Prot
MGD MGI:107928 ENTREZGENE
NCBI Gene 19378 ENTREZGENE
PANTHER ALDEHYDE DEHYDROGENASE-RELATED UniProtKB/Swiss-Prot
  RETINAL DEHYDROGENASE 2 UniProtKB/Swiss-Prot
Pfam Aldedh UniProtKB/Swiss-Prot
PhenoGen Aldh1a2 PhenoGen
PROSITE ALDEHYDE_DEHYDR_CYS UniProtKB/Swiss-Prot
  ALDEHYDE_DEHYDR_GLU UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53720 UniProtKB/Swiss-Prot
UniProt AL1A2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q6DI79 ENTREZGENE
UniProt Secondary Q6DI79 UniProtKB/Swiss-Prot