Cited2 (Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Cited2 (Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2) Mus musculus
Analyze
Symbol: Cited2
Name: Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
RGD ID: 734121
MGI Page MGI
Description: Enables several functions, including RNA polymerase II-specific DNA-binding transcription factor binding activity; SMAD binding activity; and transcription coactivator activity. Involved in several processes, including adrenal cortex formation; heart morphogenesis; and left/right pattern formation. Acts upstream of or within several processes, including circulatory system development; embryo development; and hemopoiesis. Located in chromatin and nucleus. Is expressed in several structures, including brain; embryo mesenchyme; genitourinary system; heart; and sensory organ. Used to study tetralogy of Fallot. Human ortholog(s) of this gene implicated in atrial heart septal defect 8 and ventricular septal defect. Orthologous to human CITED2 (Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI835299; cbp/p300-interacting transactivator 2; ER154-like; melanocyte specific gene 2; Mrg; MRG-1; Mrg1; Msg; MSG-related protein 1; Msg2; p35; p35srj
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391017,598,452 - 17,601,422 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1017,598,966 - 17,601,422 (+)EnsemblGRCm39 Ensembl
GRCm381017,723,228 - 17,725,674 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1017,723,218 - 17,725,674 (+)EnsemblGRCm38mm10GRCm38
MGSCv371017,443,034 - 17,445,480 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361017,412,662 - 17,415,072 (+)NCBIMGSCv36mm8
Celera1017,602,360 - 17,604,805 (+)NCBICelera
Cytogenetic Map10A2NCBI
cM Map107.18NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1,8-cineole  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrotoluene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4-hydroxyphenyl retinamide  (EXP)
4-phenylbutyric acid  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
Ampullosporin  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (EXP)
butan-1-ol  (ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
carboplatin  (ISO)
cefaloridine  (ISO)
celastrol  (ISO)
CGP 52608  (ISO)
chlorpromazine  (ISO)
chrysene  (EXP)
ciglitazone  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
doxycycline  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP)
erastin  (ISO)
ethanol  (ISO)
flavonoids  (ISO)
flurbiprofen  (EXP)
flutamide  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gedunin  (ISO)
genistein  (ISO)
gentamycin  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
isoprenaline  (EXP)
kainic acid  (ISO)
kenpaullone  (ISO)
ketamine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (EXP)
menadione  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methimazole  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (ISO)
Muraglitazar  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nefazodone  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nimesulide  (ISO)
panobinostat  (ISO)
paracetamol  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
pifithrin-alpha hydrobromide  (ISO)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (EXP,ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
resorcinol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
Soman  (ISO)
streptozocin  (EXP,ISO)
sulfadimethoxine  (ISO)
sulforaphane  (ISO)
tamoxifen  (EXP,ISO)
tauroursodeoxycholic acid  (ISO)
testosterone  (EXP,ISO)
tetraphene  (EXP)
thimerosal  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
topiramate  (ISO)
topotecan  (ISO)
trichloroethene  (EXP,ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vanadyl sulfate  (ISO)
vinclozolin  (ISO)
WIN 55212-2  (EXP)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal cortex formation  (IMP)
adrenal gland development  (IMP)
blood vessel development  (IMP)
bone morphogenesis  (IMP)
branching involved in ureteric bud morphogenesis  (IMP)
cardiac neural crest cell development involved in heart development  (IMP)
cardiac septum morphogenesis  (IMP)
cell population proliferation  (ISO,ISS)
cellular response to growth factor stimulus  (ISO)
cellular response to hypoxia  (IEA,ISO)
cellular senescence  (IEA,ISO)
central nervous system development  (IMP)
cranial nerve morphogenesis  (IMP)
decidualization  (IMP)
determination of heart left/right asymmetry  (IMP)
determination of left/right asymmetry in lateral mesoderm  (IMP)
determination of left/right symmetry  (IMP)
embryonic camera-type eye morphogenesis  (IGI)
embryonic heart tube left/right pattern formation  (IMP)
embryonic placenta development  (IMP)
embryonic process involved in female pregnancy  (IMP)
endocardial cushion development  (IMP)
erythrocyte development  (IMP)
granulocyte differentiation  (IMP)
heart development  (IMP,ISO,ISS)
heart looping  (IMP)
hematopoietic progenitor cell differentiation  (IMP)
in utero embryonic development  (IMP)
kidney development  (IMP)
left/right axis specification  (IMP)
left/right pattern formation  (IBA)
lens morphogenesis in camera-type eye  (IMP)
leukocyte differentiation  (IMP)
liver development  (IMP)
male gonad development  (IGI)
morphogenesis of an epithelium  (IMP)
negative regulation of apoptotic process  (IMP)
negative regulation of cardiac muscle cell proliferation  (IEA,ISO)
negative regulation of cell migration  (IEA,ISO)
negative regulation of DNA-templated transcription  (ISO,ISS)
negative regulation of gene expression  (ISO,ISS)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
neural tube closure  (IMP)
neural tube formation  (IMP)
nodal signaling pathway  (IMP)
outflow tract morphogenesis  (IMP)
peripheral nervous system development  (IMP)
positive regulation of cell cycle  (IMP)
positive regulation of cell-cell adhesion  (IMP)
positive regulation of DNA-templated transcription  (IDA,IEA,ISO,ISS)
positive regulation of gene expression  (ISO,ISS)
positive regulation of male gonad development  (IMP)
positive regulation of peroxisome proliferator activated receptor signaling pathway  (ISO,ISS)
positive regulation of transcription by RNA polymerase II  (IMP,ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (IDA)
pulmonary artery morphogenesis  (IMP)
regulation of animal organ formation  (IMP)
regulation of DNA-templated transcription  (TAS)
regulation of transcription by RNA polymerase II  (IDA)
response to estrogen  (ISO,ISS)
response to fluid shear stress  (IEA,ISO)
response to hypoxia  (ISO,ISS)
response to mechanical stimulus  (IEA,ISO)
sex determination  (IBA,IMP)
skeletal muscle cell differentiation  (IMP)
spleen development  (IMP)
thymus development  (IGI,IMP)
transforming growth factor beta receptor signaling pathway  (IDA)
trophectodermal cell differentiation  (IMP)
uterus development  (IMP)
vasculature development  (IGI,IMP)
vasculogenesis  (IMP)
ventricular septum development  (IMP)
ventricular septum morphogenesis  (IMP)

Cellular Component
chromatin  (IDA)
cytoplasm  (ISO,ISS)
cytosol  (IEA,ISO)
intracellular membrane-bounded organelle  (ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IDA,ISO,ISS)
protein-containing complex  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
aberrant origin of the right subclavian artery  (IAGP)
abnormal aortic arch morphology  (IAGP)
abnormal atrioventricular cushion morphology  (IAGP)
abnormal basicranium morphology  (IAGP)
abnormal blood flow velocity  (IAGP)
abnormal cardiac neural crest cell morphology  (IAGP)
abnormal cardiac outflow tract development  (IAGP)
abnormal cranial ganglia morphology  (IAGP)
abnormal direction of heart looping  (IAGP)
abnormal embryo turning  (IAGP)
abnormal glossopharyngeal ganglion morphology  (IAGP)
abnormal heart and great artery attachment  (IAGP)
abnormal heart atrium morphology  (IAGP)
abnormal heart development  (IAGP)
abnormal heart left ventricle morphology  (IAGP)
abnormal heart morphology  (IAGP)
abnormal heart position or orientation  (IAGP)
abnormal heart ventricle morphology  (IAGP)
abnormal inferior vena cava morphology  (IAGP)
abnormal interventricular septum morphology  (IAGP)
abnormal kidney development  (IAGP)
abnormal left-right axis patterning  (IAGP)
abnormal lung development  (IAGP)
abnormal neural fold formation  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal neurocranium morphology  (IAGP)
abnormal pulmonary alveolus epithelial cell morphology  (IAGP)
abnormal pulmonary alveolus morphology  (IAGP)
abnormal pulmonary trunk morphology  (IAGP)
abnormal spinal cord central canal morphology  (IAGP)
abnormal stomach position or orientation  (IAGP)
abnormal surfactant secretion  (IAGP)
abnormal tail position or orientation  (IAGP)
abnormal truncus arteriosus septation  (IAGP)
abnormal type I pneumocyte morphology  (IAGP)
abnormal type II pneumocyte morphology  (IAGP)
abnormal vagus ganglion morphology  (IAGP)
absent adrenal gland  (IAGP)
absent alveolar lamellar bodies  (IAGP)
absent cardiac neural crest cells  (IAGP)
absent coronary sinus  (IAGP)
atrial septal defect  (IAGP)
atrioventricular valve regurgitation  (IAGP)
common atrioventricular valve  (IAGP)
common atrium  (IAGP)
decreased atrioventricular cushion size  (IAGP)
decreased cardiac neural crest cell number  (IAGP)
decreased embryo size  (IAGP)
decreased fetal size  (IAGP)
decreased survivor rate  (IAGP)
dextrocardia  (IAGP)
double outlet right ventricle  (IAGP)
edema  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
exencephaly  (IAGP)
fused dorsal root ganglion  (IAGP)
hydrops fetalis  (IAGP)
impaired lung alveolus development  (IAGP)
increased embryonic neuroepithelium apoptosis  (IAGP)
interrupted aortic arch  (IAGP)
iris coloboma  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
mesocardia  (IAGP)
no abnormal phenotype detected  (IAGP)
open neural tube  (IAGP)
ostium primum atrial septal defect  (IAGP)
overriding aortic valve  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
persistent truncus arteriosus  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
pulmonary artery stenosis  (IAGP)
right aortic arch  (IAGP)
right atrial isomerism  (IAGP)
right pulmonary isomerism  (IAGP)
right-sided isomerism  (IAGP)
situs inversus  (IAGP)
small dorsal root ganglion  (IAGP)
small geniculate ganglion  (IAGP)
small lung lobe  (IAGP)
small spleen  (IAGP)
small trigeminal ganglion  (IAGP)
small vestibular ganglion  (IAGP)
transposition of great arteries  (IAGP)
vascular ring  (IAGP)
ventricular septal defect  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Folic acid prevents exencephaly in Cited2 deficient mice. Barbera JP, etal., Hum Mol Genet 2002 Feb 1;11(3):283-93.
2. Silencing of Cited2 and Akap12 genes in radiation-induced rat osteosarcomas. Daino K, etal., Biochem Biophys Res Commun. 2009 Dec 18;390(3):654-8. Epub 2009 Oct 13.
3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
4. MRG1 expression in fibroblasts is regulated by Sp1/Sp3 and an Ets transcription factor. Han B, etal., J Biol Chem 2001 Mar 16;276(11):7937-42.
5. Identification of CITED2 as a negative regulator of fracture healing. Lee JY, etal., Biochem Biophys Res Commun. 2009 Oct 2;387(4):641-5. Epub 2009 Jul 14.
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. MGD IEA MGD IEA
8. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11. Mouse MP Annotation Import Pipeline RGD automated import pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Induction of CITED2 expression in the rat hippocampus following transient global ischemia. Sun W, etal., Brain Res. 2006 Feb 9;1072(1):15-8. Epub 2006 Jan 24.
Additional References at PubMed
PMID:8889548   PMID:9434189   PMID:9533950   PMID:9811838   PMID:9887100   PMID:10349636   PMID:10593900   PMID:10922068   PMID:11042159   PMID:11044621   PMID:11076861   PMID:11217851  
PMID:11694877   PMID:11743576   PMID:12149478   PMID:12237329   PMID:12477932   PMID:12504852   PMID:12586840   PMID:12606262   PMID:12647873   PMID:14560011   PMID:14681479   PMID:14736744  
PMID:15051727   PMID:15162501   PMID:15475956   PMID:15576406   PMID:15615595   PMID:15750185   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16498405   PMID:16579983   PMID:16619037  
PMID:17022961   PMID:17036050   PMID:17133411   PMID:17353275   PMID:17537799   PMID:17615577   PMID:17644732   PMID:17932483   PMID:18158893   PMID:18287559   PMID:18330926   PMID:18358466  
PMID:18440989   PMID:18495890   PMID:18653562   PMID:18725516   PMID:19032942   PMID:19457926   PMID:19598128   PMID:19632219   PMID:19757380   PMID:19951693   PMID:20412781   PMID:20534379  
PMID:20549734   PMID:20566713   PMID:21098220   PMID:21224256   PMID:21267068   PMID:21677750   PMID:21757499   PMID:21862448   PMID:21873635   PMID:21884692   PMID:22147266   PMID:22308296  
PMID:22426420   PMID:22504313   PMID:22615585   PMID:22665973   PMID:22761414   PMID:22988430   PMID:23082118   PMID:23095882   PMID:23243273   PMID:23843232   PMID:24083546   PMID:24265312  
PMID:24550112   PMID:24586749   PMID:24803182   PMID:25377420   PMID:25976672   PMID:26141512   PMID:26240138   PMID:26384430   PMID:26450995   PMID:26874185   PMID:27307230   PMID:27606604  
PMID:27818139   PMID:28013219   PMID:28049832   PMID:28684114   PMID:29072699   PMID:29203644   PMID:29513653   PMID:30718289   PMID:30891782   PMID:30967472   PMID:30986495   PMID:31241463  
PMID:31315556   PMID:32697413   PMID:33288951   PMID:33346116   PMID:34151583   PMID:34321999   PMID:34365659   PMID:34715054   PMID:35175194   PMID:36248641   PMID:36358994   PMID:36626551  
PMID:36736544   PMID:37196079   PMID:38922923  


Genomics

Comparative Map Data
Cited2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391017,598,452 - 17,601,422 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1017,598,966 - 17,601,422 (+)EnsemblGRCm39 Ensembl
GRCm381017,723,228 - 17,725,674 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1017,723,218 - 17,725,674 (+)EnsemblGRCm38mm10GRCm38
MGSCv371017,443,034 - 17,445,480 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361017,412,662 - 17,415,072 (+)NCBIMGSCv36mm8
Celera1017,602,360 - 17,604,805 (+)NCBICelera
Cytogenetic Map10A2NCBI
cM Map107.18NCBI
CITED2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386139,371,807 - 139,374,648 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6139,371,807 - 139,374,648 (-)EnsemblGRCh38hg38GRCh38
GRCh376139,692,944 - 139,695,785 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366139,735,089 - 139,737,478 (-)NCBINCBI36Build 36hg18NCBI36
Build 346139,735,088 - 139,737,478NCBI
Celera6140,433,459 - 140,435,848 (-)NCBICelera
Cytogenetic Map6q24.1NCBI
HuRef6137,254,618 - 137,257,015 (-)NCBIHuRef
CHM1_16139,956,432 - 139,958,827 (-)NCBICHM1_1
T2T-CHM13v2.06140,555,711 - 140,558,549 (-)NCBIT2T-CHM13v2.0
Cited2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8114,132,303 - 14,134,746 (+)NCBIGRCr8
mRatBN7.2112,312,426 - 12,314,869 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl112,312,160 - 12,314,897 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx112,084,290 - 12,086,734 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0118,086,206 - 18,088,650 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0112,292,779 - 12,295,222 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0112,823,363 - 12,825,806 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl112,823,363 - 12,825,786 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0114,515,629 - 14,518,072 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4112,721,500 - 12,723,943 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1112,721,561 - 12,724,003 (+)NCBI
Celera110,778,037 - 10,780,480 (+)NCBICelera
Cytogenetic Map1p12NCBI
Cited2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543620,370,950 - 20,372,677 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543620,370,950 - 20,372,677 (+)NCBIChiLan1.0ChiLan1.0
CITED2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25159,340,343 - 159,342,756 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16157,233,726 - 157,236,144 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06137,134,142 - 137,136,550 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16141,213,671 - 141,215,919 (-)NCBIpanpan1.1PanPan1.1panPan2
CITED2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1131,522,911 - 31,525,342 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl131,523,799 - 31,524,995 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha132,396,275 - 32,398,722 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0131,684,411 - 31,686,856 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl131,685,298 - 31,686,119 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1131,559,687 - 31,562,137 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0131,442,285 - 31,444,731 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0131,753,743 - 31,756,214 (-)NCBIUU_Cfam_GSD_1.0
Cited2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946126,574,685 - 126,577,867 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365606,354,338 - 6,356,735 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365606,353,901 - 6,356,749 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CITED2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl125,155,664 - 25,160,279 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1125,155,652 - 25,158,517 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2128,295,042 - 28,297,457 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CITED2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11334,009,527 - 34,011,924 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1334,010,228 - 34,011,046 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660406,152,738 - 6,155,148 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cited2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475314,630,827 - 14,632,536 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475314,630,842 - 14,633,245 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cited2
100 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:293
Count of miRNA genes:200
Interacting mature miRNAs:233
Transcripts:ENSMUST00000038107
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11532718Sluc44f_msusceptibility to lung cancer 44f (mouse)10126289265Mouse
11532717Sluc44g_msusceptibility to lung cancer 44g (mouse)10126289265Mouse
1300881Sluc29_msusceptibility to lung cancer 29 (mouse)Not determined10126289265Mouse
12879494Facq1_mfear acquisition QTL 1 (mouse)10131279130Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101270405184079784Mouse
1300759Geot_mgeotaxia (mouse)Not determined10126289265Mouse
1558865Lith21_mlithogenic gene 21 (mouse)Not determined10852500342525126Mouse
15039341Nmrs28_mNAFLD-associated magnetic resonance shift 28 (mouse)1035100134351001Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1270405184079784Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101270405184079784Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1270405184079784Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101270405184079784Mouse
1300997Eae15_msusceptibility to experimental allergic encephalomyelitis 15 (mouse)Not determined10440815438408276Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101010826587401095Mouse
11532725Sluc44b_msusceptibility to lung cancer 44b (mouse)10126289265Mouse
1301129Alcp15_malcohol preference locus 15 (mouse)Not determined10989026443890391Mouse
11532724Sluc44c_msusceptibility to lung cancer 44c (mouse)10126289265Mouse
1301448Pas11_mpulmonary adenoma susceptibility 11 (mouse)Not determined10989026443890391Mouse
11532723Sluc44d_msusceptibility to lung cancer 44d (mouse)10126289265Mouse
11532722Sluc44e_msusceptibility to lung cancer 44e (mouse)10126289265Mouse
11532721Sluc44_msusceptibility to lung cancer 44 (mouse)10126289265Mouse
11532720Sluc44a_msusceptibility to lung cancer 44a (mouse)10126289265Mouse
1302092Ath11_matherosclerosis 11 (mouse)Not determined10615194558693521Mouse
1357813Ath20_matherosclerosis 20 (mouse)Not determined10328318537283334Mouse
1300790Pgia6_mproteoglycan induced arthritis 6 (mouse)Not determined10381017137810295Mouse
1302133Alcp16_malcohol preference locus 16 (mouse)Not determined10989026443890391Mouse
11533917Mts2_mmammary tumor susceptibility 2 (mouse)10126289265Mouse
13208570Bmiq9_mbody mass index QTL 9 (mouse)101287574424875898Mouse
1301796Mop2_mmorphine preference 2 (mouse)Not determined10928911929028424Mouse
13208561Wght8_mweight 8 (mouse)10495000043875996Mouse
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1270405184079784Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101270405184079784Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1270405184079784Mouse

Markers in Region
AI835299  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381017,725,344 - 17,725,450UniSTSGRCm38
MGSCv371017,445,150 - 17,445,256UniSTSGRCm37
Celera1017,604,475 - 17,604,581UniSTS
Cytogenetic Map10A2UniSTS
Whitehead/MRC_RH10192.83UniSTS
Cited2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381017,723,274 - 17,724,772UniSTSGRCm38
MGSCv371017,443,080 - 17,444,578UniSTSGRCm37
Celera1017,602,406 - 17,603,903UniSTS
Cytogenetic Map10A2UniSTS
cM Map10 UniSTS
Meis2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381017,724,215 - 17,724,400UniSTSGRCm38
Celera1017,603,346 - 17,603,531UniSTS
Cytogenetic Map10A2UniSTS
Cytogenetic Map2E4-E5UniSTS
RH12860  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381017,725,374 - 17,725,502UniSTSGRCm38
MGSCv371017,445,180 - 17,445,308UniSTSGRCm37
Celera1017,604,505 - 17,604,633UniSTS
Cytogenetic Map10A2UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000038107   ⟹   ENSMUSP00000038405
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1017,598,966 - 17,601,422 (+)Ensembl
GRCm38.p6 Ensembl1017,723,218 - 17,725,674 (+)Ensembl
Ensembl Acc Id: ENSMUST00000218370   ⟹   ENSMUSP00000151600
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1017,598,990 - 17,599,721 (+)Ensembl
GRCm38.p6 Ensembl1017,723,242 - 17,723,973 (+)Ensembl
Ensembl Acc Id: ENSMUST00000219558   ⟹   ENSMUSP00000151452
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1017,598,981 - 17,601,391 (+)Ensembl
GRCm38.p6 Ensembl1017,723,233 - 17,725,643 (+)Ensembl
RefSeq Acc Id: NM_010828   ⟹   NP_034958
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391017,598,976 - 17,601,422 (+)NCBI
GRCm381017,723,228 - 17,725,674 (+)NCBI
MGSCv371017,443,034 - 17,445,480 (+)RGD
Celera1017,602,360 - 17,604,805 (+)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036155664   ⟹   XP_036011557
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391017,598,452 - 17,601,404 (+)NCBI
Sequence:
RefSeq Acc Id: NP_034958   ⟸   NM_010828
- UniProtKB: O55198 (UniProtKB/Swiss-Prot),   O35743 (UniProtKB/Swiss-Prot),   O35742 (UniProtKB/Swiss-Prot),   O35741 (UniProtKB/Swiss-Prot),   Q6PGA9 (UniProtKB/Swiss-Prot),   O35740 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000151600   ⟸   ENSMUST00000218370
Ensembl Acc Id: ENSMUSP00000151452   ⟸   ENSMUST00000219558
Ensembl Acc Id: ENSMUSP00000038405   ⟸   ENSMUST00000038107
RefSeq Acc Id: XP_036011557   ⟸   XM_036155664
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35740-F1-model_v2 AlphaFold O35740 1-269 view protein structure

Promoters
RGD ID:6819114
Promoter ID:MM_KWN:3600
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000038107,   ENSMUST00000105529,   UC007ELU.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361017,442,051 - 17,444,327 (+)MPROMDB
RGD ID:8671536
Promoter ID:EPDNEW_M13799
Type:multiple initiation site
Name:Cited2_1
Description:Mus musculus Cbp/p300-interacting transactivator, with Glu/Asp-richcarboxy-terminal domain, 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381017,723,226 - 17,723,286EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1306784 AgrOrtholog
Ensembl Genes ENSMUSG00000039910 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000038107 ENTREZGENE
  ENSMUST00000038107.9 UniProtKB/Swiss-Prot
  ENSMUST00000218370.2 UniProtKB/TrEMBL
  ENSMUST00000219558.2 UniProtKB/Swiss-Prot
Gene3D-CATH 6.10.140.2200 UniProtKB/Swiss-Prot
InterPro CITED UniProtKB/Swiss-Prot
KEGG Report mmu:17684 UniProtKB/Swiss-Prot
MGD MGI:1306784 ENTREZGENE
NCBI Gene 17684 ENTREZGENE
PANTHER CBP/P300-INTERACTING TRANSACTIVATOR 2 UniProtKB/Swiss-Prot
  PTHR17045 UniProtKB/Swiss-Prot
Pfam CITED UniProtKB/Swiss-Prot
PhenoGen Cited2 PhenoGen
UniProt A0A1W2P7B1_MOUSE UniProtKB/TrEMBL
  CITE2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  O35741 ENTREZGENE
  O35742 ENTREZGENE
  O35743 ENTREZGENE
  O55198 ENTREZGENE
  Q6PGA9 ENTREZGENE
UniProt Secondary O35741 UniProtKB/Swiss-Prot
  O35742 UniProtKB/Swiss-Prot
  O35743 UniProtKB/Swiss-Prot
  O55198 UniProtKB/Swiss-Prot
  Q6PGA9 UniProtKB/Swiss-Prot