Mmp14 (matrix metallopeptidase 14 (membrane-inserted)) - Rat Genome Database

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Gene: Mmp14 (matrix metallopeptidase 14 (membrane-inserted)) Mus musculus
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Symbol: Mmp14
Name: matrix metallopeptidase 14 (membrane-inserted)
RGD ID: 734119
MGI Page MGI
Description: Enables metalloendopeptidase activity. Involved in several processes, including negative regulation of Notch signaling pathway; positive regulation of cell differentiation; and positive regulation of macrophage migration. Acts upstream of or within several processes, including chondrocyte proliferation; collagen catabolic process; and skeletal system morphogenesis. Predicted to be located in several cellular components, including cytosol; intermediate filament cytoskeleton; and macropinosome. Predicted to be active in extracellular space and plasma membrane. Predicted to colocalize with cytoplasm. Is expressed in several structures, including embryo mesenchyme; exocrine system; genitourinary system; heart; and musculoskeletal system. Used to study rheumatoid arthritis. Human ortholog(s) of this gene implicated in Winchester syndrome; esophagus adenocarcinoma; and myocardial infarction. Orthologous to human MMP14 (matrix metallopeptidase 14).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AI325305; matrix metalloproteinase 14 (membrane-inserted); matrix metalloproteinase-14; Membrane type 1-MMP; membrane-type matrix metalloproteinase 1; membrane-type-1 matrix metalloproteinase; MMP-14; MMP-X1; MT-MMP 1; MT-MMP-1; MT1-MM; MT1-MMP; MT1MMP; MTMMP1; sa; sabe; type 1 matrix metalloprotease 14
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391454,669,055 - 54,679,913 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1454,669,069 - 54,682,821 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381454,431,598 - 54,442,456 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1454,431,612 - 54,445,364 (+)Ensemblmm10GRCm38
MGSCv371455,050,441 - 55,060,095 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361453,385,824 - 53,395,458 (+)NCBIMGSCv36mm8
Celera1452,223,646 - 52,233,174 (+)NCBICelera
Cytogenetic Map14C2NCBI
cM Map1427.79NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dinitrotoluene  (ISO)
2-butoxyethanol  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
4-Nerolidylcatechol  (ISO)
4-vinylcyclohexene dioxide  (EXP)
5-aza-2'-deoxycytidine  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (ISO)
acrolein  (EXP,ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
ageladine A  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP)
aminoguanidine  (ISO)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
Azoxymethane  (EXP)
barium(0)  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
berberine  (ISO)
beta-aminopropionitrile  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (ISO)
biochanin A  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
Butylbenzyl phthalate  (EXP)
cadmium dichloride  (ISO)
capsaicin  (ISO)
carbon nanotube  (EXP)
carbonyl sulfide  (ISO)
carvone  (ISO)
CGP 52608  (ISO)
CGS-21680  (ISO)
chrysene  (EXP)
ciguatoxin CTX1B  (EXP)
cisplatin  (EXP)
clozapine  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper(II) chloride  (ISO)
cumene  (EXP)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
cysteamine  (ISO)
D-glucose  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
demethoxycurcumin  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (ISO)
diethyl phthalate  (EXP)
diethylstilbestrol  (ISO)
dihydroartemisinin  (ISO)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dimethylarsinic acid  (EXP)
dioxygen  (EXP,ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
erlotinib hydrochloride  (EXP)
ethanol  (EXP)
ethylparaben  (ISO)
finasteride  (ISO)
flutamide  (ISO)
folic acid  (EXP)
folpet  (EXP)
furan  (ISO)
gadolinium trichloride  (ISO)
Geniposide pentaacetate  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glucose  (ISO)
glycidyl methacrylate  (ISO)
graphene oxide  (EXP)
heparin  (ISO)
hydrogen cyanide  (EXP)
hydroquinone  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
inulin  (EXP)
Isoangustone A  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
ketamine  (ISO)
ketoconazole  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (EXP)
LY294002  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
mercury dibromide  (ISO)
metformin  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
methylphenidate  (ISO)
microcystin-LR  (EXP)
mifepristone  (ISO)
mitomycin C  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nickel sulfate  (EXP)
omeprazole  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentane-2,3-dione  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
piperine  (ISO)
pirinixic acid  (ISO)
potassium cyanide  (EXP)
potassium dichromate  (ISO)
pravastatin  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propiconazole  (EXP)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
Rutecarpine  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
serpentine asbestos  (EXP)
silibinin  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sotorasib  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (ISO)
trametinib  (ISO)
Trapidil  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (EXP)
triticonazole  (ISO)
tyrphostin AG 1478  (ISO)
valproic acid  (EXP,ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vorinostat  (ISO)
wortmannin  (EXP)
Y-27632  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA,ISO)
astrocyte cell migration  (IEA,ISO)
bone development  (IGI)
branching morphogenesis of an epithelial tube  (IMP)
cell migration  (IMP)
cell motility  (IEA)
cell population proliferation  (IEA)
cellular response to genistein  (IEA,ISO)
chondrocyte proliferation  (IGI)
collagen catabolic process  (IBA,IEA,IGI)
craniofacial suture morphogenesis  (IGI)
embryonic cranial skeleton morphogenesis  (IGI)
endochondral ossification  (IGI)
endodermal cell differentiation  (IEA)
endothelial cell proliferation  (IEA,ISO)
extracellular matrix organization  (IBA)
GDF15-GFRAL signaling pathway  (ISO)
head development  (IMP)
lung development  (IMP)
male gonad development  (IEA,ISO)
negative regulation of focal adhesion assembly  (IEA,ISO)
negative regulation of GDF15-GFRAL signaling pathway  (IEA,ISO)
negative regulation of Notch signaling pathway  (IMP)
ossification  (IEA,IGI,ISO)
ovarian follicle development  (IEA,ISO)
positive regulation of B cell differentiation  (IMP)
positive regulation of cell growth  (IEA,ISO)
positive regulation of cell migration  (IEA,ISO)
positive regulation of macrophage migration  (IMP)
positive regulation of myotube differentiation  (IMP)
positive regulation of protein processing  (IEA,ISO)
protein catabolic process  (IEA,ISO)
proteolysis  (IEA,ISO)
regulation of protein localization to plasma membrane  (IEA,ISO)
response to estrogen  (IEA,ISO)
response to hormone  (IEA,ISO)
response to hypoxia  (IEA,ISO)
response to mechanical stimulus  (IEA,ISO)
response to odorant  (IEA,ISO)
response to oxidative stress  (IEA,ISO)
skeletal system development  (IBA,IMP)
tissue remodeling  (IEA,ISO)
tube morphogenesis  (IEA)
zymogen activation  (IBA,IEA,IMP,ISO)

Cellular Component
cytoplasm  (IEA,ISO)
cytoplasmic vesicle  (IEA,ISO)
cytosol  (IEA,ISO)
extracellular matrix  (IEA)
extracellular space  (IBA,IEA,ISO)
Golgi membrane  (TAS)
intermediate filament cytoskeleton  (IEA,ISO)
macropinosome  (IEA,ISO)
melanosome  (IEA)
membrane  (IEA)
nucleus  (IEA,ISO)
plasma membrane  (IBA,IEA,ISO,TAS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal axial skeleton morphology  (IAGP)
abnormal basement membrane morphology  (IAGP)
abnormal blood vessel morphology  (IAGP)
abnormal bone mineralization  (IAGP)
abnormal bone ossification  (IAGP)
abnormal bone remodeling  (IAGP)
abnormal bronchiole morphology  (IAGP)
abnormal cartilage development  (IAGP)
abnormal cartilage morphology  (IAGP)
abnormal chondrocyte morphology  (IAGP)
abnormal club cell morphology  (IAGP)
abnormal compact bone morphology  (IAGP)
abnormal cranial suture morphology  (IAGP)
abnormal cranial vertex morphology  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal cranium morphology  (IAGP)
abnormal dendritic cell physiology  (IAGP)
abnormal fontanelle morphology  (IAGP)
abnormal forelimb morphology  (IAGP)
abnormal gait  (IEA)
abnormal hypodermis fat layer morphology  (IAGP)
abnormal incisor morphology  (IAGP)
abnormal interparietal bone morphology  (IAGP)
abnormal joint morphology  (IAGP)
abnormal kidney corticomedullary boundary morphology  (IAGP)
abnormal kidney development  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal kidney papilla morphology  (IAGP)
abnormal long bone epiphyseal plate morphology  (IAGP)
abnormal long bone epiphyseal plate proliferative zone  (IAGP)
abnormal long bone hypertrophic chondrocyte zone  (IAGP)
abnormal long bone morphology  (IAGP)
abnormal lung morphology  (IAGP)
abnormal mandible morphology  (IAGP)
abnormal Meckel's cartilage morphology  (IAGP)
abnormal midface morphology  (IAGP)
abnormal neurocranium morphology  (IAGP)
abnormal orbit morphology  (IAGP)
abnormal osteoclast physiology  (IAGP)
abnormal parietal bone morphology  (IAGP)
abnormal placenta labyrinth morphology  (IAGP)
abnormal placental labyrinth vasculature morphology  (IAGP)
abnormal postnatal growth/weight/body size  (IEA)
abnormal pulmonary alveolus morphology  (IAGP)
abnormal pulmonary elastic fiber morphology  (IAGP)
abnormal skeletal muscle fiber morphology  (IAGP)
abnormal skeletal muscle morphology  (IAGP)
abnormal skeleton development  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal skeleton physiology  (IAGP)
abnormal submandibular gland branching morphogenesis  (IAGP)
abnormal terminal bronchiole morphology  (IAGP)
abnormal tooth development  (IAGP)
abnormal trabecular bone morphology  (IAGP)
abnormal upper incisor morphology  (IAGP)
abnormal vomer bone morphology  (IAGP)
absent alveolar pores  (IAGP)
absent bone trabeculae  (IAGP)
absent palatine bone  (IAGP)
absent placental labyrinth  (IAGP)
absent sexual maturation  (IAGP)
autoimmune arthritis  (IAGP)
cachexia  (IAGP)
centrally nucleated skeletal muscle fibers  (IAGP)
cleft secondary palate  (IAGP)
cyanosis  (IAGP)
decreased angiogenesis  (IAGP)
decreased birth weight  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral density  (IAGP)
decreased bone ossification  (IAGP)
decreased cranium height  (IEA)
decreased cranium length  (IAGP)
decreased cranium width  (IEA)
decreased embryo size  (IAGP)
decreased kidney cell proliferation  (IAGP)
decreased length of long bones  (IAGP)
decreased locomotor activity  (IAGP)
decreased renal glomerulus number  (IAGP)
decreased submandibular gland size  (IAGP)
delayed bone ossification  (IAGP)
delayed cranial suture closure  (IAGP)
delayed endochondral bone ossification  (IAGP)
delayed intramembranous bone ossification  (IAGP)
delayed muscle development  (IAGP)
delayed tooth eruption  (IAGP)
dilated pulmonary alveolar duct  (IAGP)
dilated respiratory conducting tube  (IAGP)
dilated vasculature  (IAGP)
disproportionate dwarf  (IAGP)
domed cranium  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
enlarged optic nerve  (IEA)
enlarged pericardium  (IAGP)
exophthalmos  (IEA)
focal hair loss  (IAGP)
frontal bone hypoplasia  (IAGP)
impaired branching involved in ureteric bud morphogenesis  (IAGP)
impaired lung alveolus development  (IAGP)
impaired osteoblast differentiation  (IAGP)
increased bone marrow adipose tissue amount  (IAGP)
increased or absent threshold for auditory brainstem response  (IEA)
increased percent body fat/body weight  (IEA)
increased skeletal muscle fiber size  (IAGP)
increased width of hypertrophic chondrocyte zone  (IAGP)
infertility  (IEA)
kidney cortex hypoplasia  (IAGP)
kyphosis  (IAGP)
lethality at weaning, complete penetrance  (IAGP)
loose skin  (IAGP)
lordosis  (IAGP)
macrophthalmia  (IEA)
malocclusion  (IAGP)
maxilla hypoplasia  (IAGP)
nasal bone hypoplasia  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
osteoporosis  (IAGP)
overexpanded pulmonary alveolus  (IAGP)
palatal shelf hypoplasia  (IAGP)
palatal shelves fail to meet at midline  (IAGP)
parietal bone hypoplasia  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, incomplete penetrance  (IEA)
pterygoid bone hypoplasia  (IAGP)
pulmonary hypoplasia  (IAGP)
round head  (IEA)
short femur  (IAGP)
short humerus  (IAGP)
short incisors  (IAGP)
short limbs  (IAGP)
short lower incisors  (IAGP)
short mandible  (IAGP)
short maxilla  (IAGP)
short snout  (IAGP)
short upper incisors  (IAGP)
skeletal muscle fibrosis  (IAGP)
skeletal muscle interstitial fibrosis  (IAGP)
skin fibrosis  (IAGP)
small cranial cavity  (IAGP)
small ears  (IEA)
small kidney  (IAGP)
small lung  (IAGP)
small mandible  (IAGP)
thin diaphragm muscle  (IAGP)
thin neurocranium  (IAGP)
vomer bone hypoplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Up-regulation of matrix metalloproteinase-2 and membrane-type 1-matrix metalloproteinase were coupled with that of type I procollagen in granulation tissue response after the onset of aortic dissection. Akiyama M, etal., Virchows Arch. 2006 Jun;448(6):811-21. Epub 2006 Apr 12.
2. Differential regulation of matrix metalloproteinase activities in abdominal aortic aneurysms. Annabi B, etal., J Vasc Surg. 2002 Mar;35(3):539-46.
3. Upregulated expression and activation of membrane‑associated proteases in esophageal squamous cell carcinoma. Augoff K, etal., Oncol Rep. 2014 Jun;31(6):2820-6. doi: 10.3892/or.2014.3162. Epub 2014 Apr 29.
4. Vascular extracellular matrix remodeling in cerebral aneurysms. Bruno G, etal., J Neurosurg. 1998 Sep;89(3):431-40.
5. Identification of new therapeutic targets by genome-wide analysis of gene expression in the ipsilateral cortex of aged rats after stroke. Buga AM, etal., PLoS One. 2012;7(12):e50985. doi: 10.1371/journal.pone.0050985. Epub 2012 Dec 12.
6. Upregulation of extracellular matrix metalloproteinase inducer (EMMPRIN) and gelatinases in human atherosclerosis infected with Chlamydia pneumoniae: the potential role of Chlamydia pneumoniae infection in the progression of atherosclerosis. Choi EY, etal., Exp Mol Med. 2002 Dec 31;34(6):391-400.
7. Ischemia-induced cleavage of cadherins in NRK cells requires MT1-MMP (MMP-14). Covington MD, etal., Am J Physiol Renal Physiol. 2006 Jan;290(1):F43-51. Epub 2005 Aug 2.
8. Differential transcriptional activation of matrix metalloproteinase-2 and membrane type-1 matrix metalloproteinase by experimental deep venous thrombosis and thrombin. Dahi S, etal., J Vasc Surg. 2005 Sep;42(3):539-45.
9. MT1-matrix metalloproteinase directs arterial wall invasion and neointima formation by vascular smooth muscle cells. Filippov S, etal., J Exp Med. 2005 Sep 5;202(5):663-71.
10. Enhanced expression of membrane type-1 matrix metalloproteinase in mesangial proliferative glomerulonephritis. Hayashi K, etal., J Am Soc Nephrol. 1998 Dec;9(12):2262-71.
11. Macrophage-derived MT1-MMP and increased MMP-2 activity are associated with glomerular damage in crescentic glomerulonephritis. Hayashi K, etal., J Pathol. 2000 Jul;191(3):299-305.
12. Angiotensin type 1 receptor blockage improves ischemic injury following transient focal cerebral ischemia. Hosomi N, etal., Neuroscience. 2005;134(1):225-31.
13. Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with Marfan syndrome. Ikonomidis JS, etal., Circulation. 2006 Jul 4;114(1 Suppl):I365-70.
14. Combination of tumor necrosis factor-alpha ablation and matrix metalloproteinase inhibition prevents heart failure after pressure overload in tissue inhibitor of metalloproteinase-3 knock-out mice. Kassiri Z, etal., Circ Res. 2005 Aug 19;97(4):380-90. Epub 2005 Jul 21.
15. Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human urothelial carcinomas. Kitagawa Y, etal., J Urol. 1998 Oct;160(4):1540-5.
16. MGDs mouse GO annotations MGD data from the GO Consortium
17. MGD IEA MGD IEA
18. Decreased vascular matrix metalloproteinase abundance in diabetic patients with symptomatic macroangiopathy. Mondy JS, etal., Ethn Dis. 2002 Fall;12(4):S3-18-22.
19. Elevated expression of extracellular matrix metalloproteinase inducer (CD147) and membrane-type matrix metalloproteinases in venous leg ulcers. Norgauer J, etal., Br J Dermatol. 2002 Dec;147(6):1180-6.
20. Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas. Okada A, etal., Proc Natl Acad Sci U S A 1995 Mar 28;92(7):2730-4.
21. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
22. Increased expression and activity of matrix metalloproteinases characterize embolic cardiac myxomas. Orlandi A, etal., Am J Pathol. 2005 Jun;166(6):1619-28.
23. Evolution of matrix metalloprotease and tissue inhibitor expression during heart failure progression in the infarcted rat. Peterson JT, etal., Cardiovasc Res. 2000 May;46(2):307-15.
24. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
25. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
26. Mouse MP Annotation Import Pipeline RGD automated import pipeline
27. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. Extracellular matrix metalloproteinase inducer regulates matrix metalloproteinase activity in cardiovascular cells: implications in acute myocardial infarction. Schmidt R, etal., Circulation. 2006 Feb 14;113(6):834-41. Epub 2006 Feb 6.
30. Early MT-1 MMP expression following elastase exposure is associated with increased cleaved MMP-2 activity in experimental rodent aortic aneurysms. Sinha I, etal., Surgery. 2004 Aug;136(2):176-82.
31. Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human invasive breast carcinomas. Ueno H, etal., Cancer Res. 1997 May 15;57(10):2055-60.
32. Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma. Wu IC, etal., Neoplasia. 2011 Apr;13(4):386-92. doi: 10.1593/neo.101722.
Additional References at PubMed
PMID:8015608   PMID:8743942   PMID:9037199   PMID:9325265   PMID:9648071   PMID:10349636   PMID:10419448   PMID:10433819   PMID:10520996   PMID:10737763   PMID:10949577   PMID:11042159  
PMID:11076861   PMID:11165481   PMID:11217851   PMID:11221894   PMID:11359935   PMID:11675412   PMID:11747814   PMID:11828004   PMID:11865039   PMID:11973313   PMID:12049638   PMID:12477932  
PMID:12507218   PMID:12592384   PMID:12815621   PMID:12842442   PMID:12900459   PMID:12950084   PMID:12952212   PMID:12952213   PMID:14610065   PMID:14688206   PMID:14979875   PMID:15064723  
PMID:15094525   PMID:15304103   PMID:15456762   PMID:15516694   PMID:15522913   PMID:15545316   PMID:15557125   PMID:15563592   PMID:15572153   PMID:15601659   PMID:15695374   PMID:15734845  
PMID:15739229   PMID:15782199   PMID:15800063   PMID:15805464   PMID:15895410   PMID:15944163   PMID:15978592   PMID:16113801   PMID:16141072   PMID:16141073   PMID:16158179   PMID:16234249  
PMID:16236725   PMID:16251193   PMID:16551362   PMID:16678100   PMID:16778201   PMID:16926191   PMID:17018528   PMID:17136358   PMID:17204469   PMID:17229722   PMID:17393098   PMID:17405818  
PMID:17483344   PMID:17548469   PMID:17557804   PMID:17606763   PMID:17620416   PMID:17623673   PMID:17709990   PMID:18022611   PMID:18071307   PMID:18250269   PMID:18445063   PMID:18541723  
PMID:18627313   PMID:18639653   PMID:18663148   PMID:18762577   PMID:18799693   PMID:19010778   PMID:19051246   PMID:19066283   PMID:19085378   PMID:19197139   PMID:19264910   PMID:19371380  
PMID:19419317   PMID:19542530   PMID:19566825   PMID:19571574   PMID:19706774   PMID:19855192   PMID:19898483   PMID:19915148   PMID:20049897   PMID:20056917   PMID:20152179   PMID:20223936  
PMID:20356925   PMID:20418476   PMID:20620173   PMID:20643648   PMID:20660624   PMID:20663879   PMID:20727881   PMID:20858856   PMID:20978081   PMID:21267068   PMID:21372132   PMID:21436261  
PMID:21572390   PMID:21641389   PMID:21666120   PMID:21738685   PMID:21840960   PMID:21873635   PMID:21893028   PMID:22014525   PMID:22171010   PMID:22202174   PMID:22262018   PMID:22345520  
PMID:22423112   PMID:22464947   PMID:22544701   PMID:22632802   PMID:22670674   PMID:22687584   PMID:22688677   PMID:22717126   PMID:22859368   PMID:22971618   PMID:23091646   PMID:23250208  
PMID:23334579   PMID:23349620   PMID:23413031   PMID:23421805   PMID:23438179   PMID:23438475   PMID:23685250   PMID:23984338   PMID:24095877   PMID:24136919   PMID:24395927   PMID:24492617  
PMID:24611815   PMID:24990232   PMID:25015352   PMID:25180193   PMID:25636537   PMID:25664857   PMID:25735873   PMID:25770908   PMID:25794647   PMID:25920569   PMID:25991604   PMID:26234751  
PMID:26390284   PMID:26724533   PMID:26780723   PMID:26926389   PMID:27066886   PMID:27085457   PMID:27435625   PMID:27573347   PMID:27633994   PMID:27736644   PMID:28120021   PMID:28531375  
PMID:28692057   PMID:28735290   PMID:28763805   PMID:28914985   PMID:28993312   PMID:29033361   PMID:29196321   PMID:29401593   PMID:29567669   PMID:29643184   PMID:29712618   PMID:29934628  
PMID:30160940   PMID:30269950   PMID:30389913   PMID:30521382   PMID:30822518   PMID:31297933   PMID:31366822   PMID:31600777   PMID:31677819   PMID:31793743   PMID:31988105   PMID:32024800  
PMID:32208136   PMID:32229724   PMID:32268857   PMID:32325033   PMID:32523119   PMID:32730638   PMID:33000497   PMID:33063665   PMID:33294797   PMID:33767172   PMID:33805743   PMID:34048934  
PMID:34572097   PMID:34830157   PMID:34968503   PMID:35140200   PMID:35150612   PMID:35364055   PMID:35446024   PMID:36073351   PMID:36162272   PMID:36302921   PMID:36465133   PMID:36564389  
PMID:36892459   PMID:37139431   PMID:37261735   PMID:37598898   PMID:37701782   PMID:37913834   PMID:38670210   PMID:38990714   PMID:39217171   PMID:39415005   PMID:39746830   PMID:40207531  


Genomics

Comparative Map Data
Mmp14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391454,669,055 - 54,679,913 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1454,669,069 - 54,682,821 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381454,431,598 - 54,442,456 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1454,431,612 - 54,445,364 (+)Ensemblmm10GRCm38
MGSCv371455,050,441 - 55,060,095 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361453,385,824 - 53,395,458 (+)NCBIMGSCv36mm8
Celera1452,223,646 - 52,233,174 (+)NCBICelera
Cytogenetic Map14C2NCBI
cM Map1427.79NCBI
MMP14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381422,836,585 - 22,847,758 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1422,836,560 - 22,849,041 (+)Ensemblhg38GRCh38
GRCh371423,305,794 - 23,316,967 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361422,375,633 - 22,386,643 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341422,375,632 - 22,386,642NCBI
Celera143,168,679 - 3,179,688 (+)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef143,422,922 - 3,433,986 (+)NCBIHuRef
CHM1_11423,304,418 - 23,315,462 (+)NCBICHM1_1
T2T-CHM13v2.01417,034,651 - 17,045,822 (+)NCBIT2T-CHM13v2.0
Mmp14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81531,857,824 - 31,867,049 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1531,857,546 - 31,869,893 (+)EnsemblGRCr8
mRatBN7.21527,887,795 - 27,897,020 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1527,887,727 - 27,899,864 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1529,727,071 - 29,736,290 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01530,874,288 - 30,883,507 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01529,124,651 - 29,133,873 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01533,074,441 - 33,083,666 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1533,074,441 - 33,083,655 (+)Ensemblrn6Rnor6.0
Rnor_5.01536,960,282 - 36,969,507 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41532,493,852 - 32,503,077 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1527,470,861 - 27,480,086 (+)NCBICelera
RGSC_v3.11532,509,551 - 32,518,777 (+)NCBI
Cytogenetic Map15p13NCBI
Mmp14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540937,440,541 - 37,448,437 (-)Ensembl
ChiLan1.0NW_00495540937,438,924 - 37,448,704 (-)NCBIChiLan1.0ChiLan1.0
MMP14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21524,266,301 - 24,277,533 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11423,482,405 - 23,494,022 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0143,654,125 - 3,665,158 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11421,753,305 - 21,764,061 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1421,753,305 - 21,764,058 (+)EnsemblpanPan2panpan1.1
MMP14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.183,183,419 - 3,193,079 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl83,183,606 - 3,194,122 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha83,132,308 - 3,142,668 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.083,291,562 - 3,301,919 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl83,291,310 - 3,301,917 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.182,983,033 - 2,993,386 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.083,044,810 - 3,055,166 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.083,306,779 - 3,317,137 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mmp14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864034,931,359 - 34,941,231 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367221,447,335 - 1,457,611 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367221,447,189 - 1,457,632 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MMP14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl776,172,971 - 76,185,928 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1776,174,502 - 76,185,931 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2781,413,927 - 81,424,899 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MMP14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12923,201,425 - 23,212,408 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2923,201,112 - 23,212,679 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605923,209,848 - 23,220,925 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mmp14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248209,667,262 - 9,677,774 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248209,667,371 - 9,677,488 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Mmp14
346 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:246
Count of miRNA genes:193
Interacting mature miRNAs:209
Transcripts:ENSMUST00000089688
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1300625Cosz2_mcocaine seizure 2 (mouse)Not determined143504579768785736Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144296241676962593Mouse
1301489Lbm10_mlean body mass 10 (mouse)Not determined145376129687761529Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144296241676962593Mouse
4142364Pbwg18_mpostnatal body weight growth 18 (mouse)Not determined145228198486282125Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144306584777066045Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
4142485Modor2_mmodifier of ocular retardation 2 (mouse)Not determined142492624858179769Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4033731974337319Mouse
27226737Metcl12_mmetatarsal-calcaneal length 12, 10 week (mouse)143322195759437449Mouse
1300605El5_mepilepsy 5 (mouse)Not determined144945542583455556Mouse
1301091Bbaa21_mB.burgdorferi-associated arthritis 21 (mouse)Not determined144306584777066045Mouse
4141484Hcbip1_mhexachlorobenzene induced porphyria 1 (mouse)Not determined4733525059962593Mouse
12880432Fgf23lq3_mFGF23 serum level QTL 3 (mouse)145393744087937440Mouse
1300998Cia17_mcollagen induced arthritis 17 (mouse)Not determined143033525064335381Mouse
10043887Cia50_mcollagen induced arthritis QTL 50 (mouse)Not determined143743018571430320Mouse
1300805Mors3_mmodifier of obesity related sterility 3 (mouse)Not determined144303727077037418Mouse
10043886Cia49_mcollagen induced arthritis QTL 49 (mouse)Not determined142999699463997133Mouse
14746973Manh76_mmandible shape 76 (mouse)142228721756287217Mouse
1300909Ath13_matherosclerosis 13 (mouse)Not determined143033525064335381Mouse
13506929Recrq10_mrecombination rate in male meiosis QTL 10 (mouse)142792195761137449Mouse

Markers in Region
AI325305  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381454,440,400 - 54,440,507UniSTSGRCm38
MGSCv371455,059,237 - 55,059,344UniSTSGRCm37
Celera1452,232,316 - 52,232,423UniSTS
Cytogenetic Map14C2UniSTS
cM Map1412.5UniSTS
Whitehead/MRC_RH14620.35UniSTS
Mmp14  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371455,057,881 - 55,059,490UniSTSGRCm37
MGSCv371455,058,232 - 55,058,815UniSTSGRCm37
MGSCv371455,053,910 - 55,054,140UniSTSGRCm37
Celera1452,227,115 - 52,227,371UniSTS
Celera1452,231,306 - 52,231,889UniSTS
Celera1452,230,955 - 52,232,569UniSTS
Cytogenetic Map14C2UniSTS
cM Map1412.5UniSTS
cM Map1412.5UniSTS
cM Map1412.5UniSTS
MARC_9867-9868:996688667:1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381454,439,375 - 54,440,406UniSTSGRCm38
MGSCv371455,058,212 - 55,059,243UniSTSGRCm37
Celera1452,231,286 - 52,232,322UniSTS
Cytogenetic Map14C2UniSTS
cM Map1412.5UniSTS
Mmp14  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381454,435,073 - 54,435,303UniSTSGRCm38
MGSCv371455,053,910 - 55,054,140UniSTSGRCm37
Celera1452,227,115 - 52,227,371UniSTS
Cytogenetic Map14C2UniSTS
cM Map1412.5UniSTS
Mmp14  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381454,439,044 - 54,440,653UniSTSGRCm38
MGSCv371455,057,881 - 55,059,490UniSTSGRCm37
Celera1452,230,955 - 52,232,569UniSTS
Cytogenetic Map14C2UniSTS
cM Map1412.5UniSTS
MMP14  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381454,439,395 - 54,439,978UniSTSGRCm38
MGSCv371455,058,232 - 55,058,815UniSTSGRCm37
Celera1452,231,306 - 52,231,889UniSTS
Cytogenetic Map14C2UniSTS
Mmp14  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14C2UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_008608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC164433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC206013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH005635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK040968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK134340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK138611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK180055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK180818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK182079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK182471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK183589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK203136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK209696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY622974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC076638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY700899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ249870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U54984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  W75261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X83536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000089688   ⟹   ENSMUSP00000087119
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1454,669,069 - 54,678,722 (+)Ensembl
GRCm38.p6 Ensembl1454,431,612 - 54,441,265 (+)Ensembl
Ensembl Acc Id: ENSMUST00000196155   ⟹   ENSMUSP00000143012
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1454,669,893 - 54,673,329 (+)Ensembl
GRCm38.p6 Ensembl1454,432,436 - 54,435,872 (+)Ensembl
Ensembl Acc Id: ENSMUST00000197874   ⟹   ENSMUSP00000142665
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1454,669,080 - 54,673,645 (+)Ensembl
GRCm38.p6 Ensembl1454,431,623 - 54,436,188 (+)Ensembl
Ensembl Acc Id: ENSMUST00000197947
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1454,669,121 - 54,673,617 (+)Ensembl
GRCm38.p6 Ensembl1454,431,664 - 54,436,160 (+)Ensembl
Ensembl Acc Id: ENSMUST00000198679
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1454,669,175 - 54,670,722 (+)Ensembl
GRCm38.p6 Ensembl1454,431,718 - 54,433,265 (+)Ensembl
Ensembl Acc Id: ENSMUST00000225641   ⟹   ENSMUSP00000153679
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1454,669,090 - 54,682,821 (+)Ensembl
GRCm38.p6 Ensembl1454,431,633 - 54,445,364 (+)Ensembl
Ensembl Acc Id: ENSMUST00000226710
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1454,676,049 - 54,677,936 (+)Ensembl
GRCm38.p6 Ensembl1454,438,592 - 54,440,479 (+)Ensembl
RefSeq Acc Id: NM_008608   ⟹   NP_032634
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391454,669,055 - 54,679,913 (+)NCBI
GRCm381454,431,598 - 54,442,456 (+)NCBI
MGSCv371455,050,441 - 55,060,095 (+)RGD
Celera1452,223,646 - 52,233,174 (+)RGD
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_032634   ⟸   NM_008608
- Peptide Label: preproprotein
- UniProtKB: O35369 (UniProtKB/Swiss-Prot),   O08645 (UniProtKB/Swiss-Prot),   Q8BTX2 (UniProtKB/Swiss-Prot),   P53690 (UniProtKB/Swiss-Prot),   Q3TQH0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000142665   ⟸   ENSMUST00000197874
Ensembl Acc Id: ENSMUSP00000153679   ⟸   ENSMUST00000225641
Ensembl Acc Id: ENSMUSP00000087119   ⟸   ENSMUST00000089688
Ensembl Acc Id: ENSMUSP00000143012   ⟸   ENSMUST00000196155
Protein Domains
Peptidase M10A matrix metallopeptidase C-terminal   Peptidase metallopeptidase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P53690-F1-model_v2 AlphaFold P53690 1-582 view protein structure

Promoters
RGD ID:8682338
Promoter ID:EPDNEW_M19199
Type:initiation region
Name:Mmp14_1
Description:Mus musculus matrix metallopeptidase 14 (membrane-inserted) ,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381454,431,648 - 54,431,708EPDNEW
RGD ID:6825184
Promoter ID:MM_KWN:16869
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000089688
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361455,049,451 - 55,050,652 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:101900 AgrOrtholog
Ensembl Genes ENSMUSG00000000957 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000089688 ENTREZGENE
  ENSMUST00000089688.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.101.10 UniProtKB/Swiss-Prot
  2.110.10.10 UniProtKB/Swiss-Prot
  3.40.390.10 UniProtKB/Swiss-Prot
InterPro Hemopexin-like_dom UniProtKB/Swiss-Prot
  Hemopexin-like_dom_sf UniProtKB/Swiss-Prot
  Hemopexin-like_repeat UniProtKB/Swiss-Prot
  Hemopexin_CS UniProtKB/Swiss-Prot
  M10A_MMP UniProtKB/Swiss-Prot
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot
  Pept_M10_metallopeptidase UniProtKB/Swiss-Prot
  Pept_M10A UniProtKB/Swiss-Prot
  Pept_M10A_metallopeptidase_C UniProtKB/Swiss-Prot
  Pept_M10A_Zn_BS UniProtKB/Swiss-Prot
  Peptidase_Metallo UniProtKB/Swiss-Prot
  Peptidoglycan-bd-like UniProtKB/Swiss-Prot
  PGBD-like_sf UniProtKB/Swiss-Prot
  PGBDSf UniProtKB/Swiss-Prot
KEGG Report mmu:17387 UniProtKB/Swiss-Prot
MGD MGI:101900 ENTREZGENE
NCBI Gene 17387 ENTREZGENE
PANTHER MATRIX METALLOPROTEINASE UniProtKB/Swiss-Prot
  MATRIX METALLOPROTEINASE-14 UniProtKB/Swiss-Prot
Pfam DUF3377 UniProtKB/Swiss-Prot
  Hemopexin UniProtKB/Swiss-Prot
  Peptidase_M10 UniProtKB/Swiss-Prot
  PG_binding_1 UniProtKB/Swiss-Prot
PhenoGen Mmp14 PhenoGen
PIRSF Peptidase_M10A_matrix UniProtKB/Swiss-Prot
PRINTS MATRIXIN UniProtKB/Swiss-Prot
PROSITE CYSTEINE_SWITCH UniProtKB/Swiss-Prot
  HEMOPEXIN UniProtKB/Swiss-Prot
  HEMOPEXIN_2 UniProtKB/Swiss-Prot
  ZINC_PROTEASE UniProtKB/Swiss-Prot
SMART SM00120 UniProtKB/Swiss-Prot
  ZnMc UniProtKB/Swiss-Prot
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot
  SSF47090 UniProtKB/Swiss-Prot
  SSF50923 UniProtKB/Swiss-Prot
UniProt A0A0G2JE78_MOUSE UniProtKB/TrEMBL
  A0A0G2JF39_MOUSE UniProtKB/TrEMBL
  A0A286YED2_MOUSE UniProtKB/TrEMBL
  MMP14_MOUSE UniProtKB/Swiss-Prot
  O08645 ENTREZGENE
  O35369 ENTREZGENE
  P53690 ENTREZGENE
  Q3TQH0 ENTREZGENE, UniProtKB/TrEMBL
  Q3U2T0_MOUSE UniProtKB/TrEMBL
  Q6DFU5_MOUSE UniProtKB/TrEMBL
  Q6GX97_MOUSE UniProtKB/TrEMBL
  Q8BTX2 ENTREZGENE
UniProt Secondary O08645 UniProtKB/Swiss-Prot
  O35369 UniProtKB/Swiss-Prot
  Q8BTX2 UniProtKB/Swiss-Prot