Trpc2 (transient receptor potential cation channel, subfamily C, member 2) - Rat Genome Database

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Gene: Trpc2 (transient receptor potential cation channel, subfamily C, member 2) Mus musculus
Analyze
Symbol: Trpc2
Name: transient receptor potential cation channel, subfamily C, member 2
RGD ID: 734117
MGI Page MGI
Description: Enables diacylglycerol binding activity; inositol 1,4,5 trisphosphate binding activity; and store-operated calcium channel activity. Acts upstream of or within several processes, including female courtship behavior; inter-male aggressive behavior; and mating behavior, sex discrimination. Located in dendrite membrane and endomembrane system. Is expressed in brain; ganglia; genitourinary system; sensory organ; and skeletal muscle. Orthologous to human TRPC2 (transient receptor potential cation channel subfamily C member 2 (pseudogene)).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3010009O07Rik; AI115608; mTr; mTrp2; short transient receptor potential channel 2; smTRPC2; tr; transient receptor potential 2-like protein; transient receptor protein 2; TRP; TRP-2; trp2; TRPC; TRPC2a; TRPC2b; Trrp2
RGD Orthologs
Human
Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397101,732,323 - 101,746,071 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7101,732,323 - 101,745,603 (+)EnsemblGRCm39 Ensembl
GRCm387102,083,116 - 102,096,864 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7102,083,116 - 102,096,396 (+)EnsemblGRCm38mm10GRCm38
MGSCv377109,214,227 - 109,244,930 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367101,949,701 - 101,970,155 (+)NCBIMGSCv36mm8
Celera7102,440,894 - 102,463,475 (+)NCBICelera
Cytogenetic Map7E2NCBI
cM Map754.71NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. Zhu X, etal., Cell 1996 May 31;85(5):661-71.
Additional References at PubMed
PMID:9722956   PMID:10051594   PMID:10225993   PMID:10318963   PMID:10349636   PMID:10998353   PMID:11042159   PMID:11076861   PMID:11331878   PMID:11390792   PMID:11823606   PMID:11972034  
PMID:12167663   PMID:12477932   PMID:12601176   PMID:12629181   PMID:12631698   PMID:14505576   PMID:14610273   PMID:14642279   PMID:14699131   PMID:15329338   PMID:15336983   PMID:15385169  
PMID:15483558   PMID:15589997   PMID:16141072   PMID:16141073   PMID:16153633   PMID:16460286   PMID:16602821   PMID:16820028   PMID:17480026   PMID:17676034   PMID:18287559   PMID:18799693  
PMID:18989690   PMID:19322198   PMID:19501082   PMID:19521566   PMID:19706712   PMID:19797157   PMID:19799641   PMID:19834762   PMID:20147653   PMID:20478258   PMID:20573694   PMID:20596023  
PMID:21070815   PMID:21267068   PMID:21452247   PMID:21677750   PMID:21694713   PMID:21873635   PMID:21924222   PMID:21937988   PMID:22411552   PMID:22573694   PMID:22723178   PMID:22842147  
PMID:23637329   PMID:24089208   PMID:24587340   PMID:24828191   PMID:25001287   PMID:25090970   PMID:25471572   PMID:25578906   PMID:25701815   PMID:26321906   PMID:26878847   PMID:27177420  
PMID:27535696   PMID:27840094   PMID:27916458   PMID:28659282   PMID:28757304   PMID:29066740   PMID:29241537   PMID:29276045   PMID:30233329   PMID:30270038   PMID:30550786   PMID:30712868  
PMID:30786075   PMID:30804203   PMID:31653840   PMID:32350291   PMID:32846119   PMID:32961129   PMID:33884443   PMID:34186026   PMID:36592529   PMID:36796363   PMID:37424020   PMID:37496437  
PMID:38355793   PMID:38835669  


Genomics

Comparative Map Data
Trpc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397101,732,323 - 101,746,071 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7101,732,323 - 101,745,603 (+)EnsemblGRCm39 Ensembl
GRCm387102,083,116 - 102,096,864 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7102,083,116 - 102,096,396 (+)EnsemblGRCm38mm10GRCm38
MGSCv377109,214,227 - 109,244,930 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367101,949,701 - 101,970,155 (+)NCBIMGSCv36mm8
Celera7102,440,894 - 102,463,475 (+)NCBICelera
Cytogenetic Map7E2NCBI
cM Map754.71NCBI
TRPC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38113,626,460 - 3,637,559 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl113,616,679 - 3,637,549 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p14 Ensembl113,626,438 - 3,637,677 (+)EnsemblGRCh38hg38GRCh38
GRCh37113,647,690 - 3,658,789 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36113,604,290 - 3,615,365 (+)NCBINCBI36Build 36hg18NCBI36
Build 34113,604,289 - 3,615,365NCBI
Celera113,659,826 - 3,663,093 (+)NCBICelera
Cytogenetic Map11p15.4NCBI
HuRef113,384,984 - 3,396,073 (+)NCBIHuRef
CHM1_1113,646,765 - 3,657,866 (+)NCBICHM1_1
T2T-CHM13v2.0113,671,928 - 3,682,997 (+)NCBIT2T-CHM13v2.0
Trpc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81165,871,991 - 165,885,339 (+)NCBIGRCr8
mRatBN7.21156,460,009 - 156,473,039 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1156,440,305 - 156,473,073 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1164,437,596 - 164,450,988 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01171,617,684 - 171,631,076 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01164,494,996 - 164,508,394 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01167,180,103 - 167,192,456 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1167,169,442 - 167,192,801 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01173,368,155 - 173,381,696 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41159,542,801 - 159,576,294 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11159,642,649 - 159,655,999 (+)NCBI
Celera1154,528,993 - 154,541,346 (+)NCBICelera
Cytogenetic Map1q32NCBI

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:7632
Count of miRNA genes:881
Interacting mature miRNAs:1230
Transcripts:ENSMUST00000084843, ENSMUST00000094129, ENSMUST00000094130, ENSMUST00000106943, ENSMUST00000106950, ENSMUST00000123372, ENSMUST00000124189, ENSMUST00000125197, ENSMUST00000139104, ENSMUST00000140395, ENSMUST00000141646, ENSMUST00000142629, ENSMUST00000143839, ENSMUST00000146450, ENSMUST00000153176, ENSMUST00000155078
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357460Vtbt4_mvertebral trabecular bone trait 4 (mouse)Not determined7101693381135693530Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
27226781Tibl3_mtibia length 3, 5 week (mouse)774849748122199223Mouse
25314305Vmm6_mvariable multisystem mineralization 6, eye (mouse)761849748102749207Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)756949748134001729Mouse
1301781Capsq3_mcapsaicin sensitivity related QTL 3 (mouse)Not determined787143137119485380Mouse
14746989Manh62_mmandible shape 62 (mouse)775742528109742528Mouse
11039524Tbbr3_mTrypanosoma brucei brucei response 3 (mouse)7100750722134750843Mouse
27226769Tibl12_mtibia length 12, 10 week (mouse)787249208126499172Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745161966118693530Mouse
27226765Tibl18_mtibia length 18, 16 week (mouse)781849748126499172Mouse
27226763Feml20_mfemur length 20, 16 week (mouse)785049208124199223Mouse
4142500Morq1_mmodifier of Rs1 QTL 1 (mouse)Not determined80551681114551791Mouse
1301647Elpt_melevated leptin (mouse)Not determined786500186120500329Mouse
13208555Lgth10_mbody length 10 (mouse)751649748125599172Mouse
26884408Bzwq13_mbi-zygomatic width QTL 13, 16 week (mouse)761749748121399223Mouse
1301937Skull10_mskull morphology 10 (mouse)Not determined791482996125483156Mouse
1300528Ssial3_msusceptibility to sialadenitis 3 (mouse)Not determined793391848127392041Mouse
1300791Abbp3_mA/J and C57BL/6 blood pressure 3 (mouse)Not determined739673887103510010Mouse
1301566Adip3_madiposity 3 (mouse)Not determined775394215109394346Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730199425108999207Mouse
1301155Bpq7_mblood pressure QTL 7 (mouse)Not determined770143137104143379Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)778649748136901729Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
27226790Feml15_mfemur length 15, 10 week (mouse)787249208126499172Mouse
13524850Asrq7_macoustic startle response 7 (mouse)798394974132394974Mouse
1300654Bomd1_mbone mineral density 1 (mouse)Not determined768365595102365702Mouse
1302062Stheal6_msoft tissue heal 6 (mouse)Not determined787043932121044066Mouse
26884440Sklq4_mskull length QTL 4, 5 week (mouse)765249748126499172Mouse
27095903Scvln10_msacral vertebrae length 2, 10 week (mouse)781449748126499172Mouse
27226715Metcl3_mmetatarsal-calcaneal length 3, 5 week (mouse)767849748119499223Mouse
26884444Sklq8_mskull length QTL 8, 10 week (mouse)767849748124199223Mouse
25823170Hrsq7_mhost response to SARS QTL 7, log titer (mouse)754819589116822815Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736280015116416877Mouse
10412110Cctq1_mcentral corneal thickness QTL 1 (mouse)Not determined780551681114551791Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1301447Fembm3_mfemoral bone morphometry 3 (mouse)Not determined7100993261134993342Mouse
10412104Tons2_mtongue size 2 (mouse)Not determined799837716133837716Mouse
1301188Heal6_mwound healing/regeneration 6 (mouse)Not determined787043932121044066Mouse
26884418Bzwq7_mbi-zygomatic width QTL 7, 10 week (mouse)767849748105449207Mouse
10043973Obq29_mobesity QTL 29 (mouse)Not determined772263372106263372Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
1301105Cfld4_mcystic fibrosis lung disease 4 (mouse)Not determined7101693381135693530Mouse
1300721Cfbw3_mcystic fibrosis body weight 3 (mouse)Not determined7101693381135693530Mouse
27095929Pglq8_mpelvic girdle length QTL 8, 10 week (mouse)787849208108099207Mouse
27226745Metcl9_mmetatarsal-calcaneal length 9, 10 week (mouse)774849748122199223Mouse
27095930Ulnl10_mulna length 10, 16 week (mouse)780849748126699172Mouse
27095923Pglq3_mpelvic girdle length QTL 3, 5 week (mouse)781249748124199223Mouse
27095916Scvln15_msacral vertebrae length 2, 16 week (mouse)761749748123699223Mouse
13464255Ifvrq2_minfluenza virus resistance QTL 2 (mouse)792500698106455693Mouse
1357664Nba3_mNew Zealand Black autoimmunity 3 (mouse)Not determined791482996125483156Mouse
1301478Eae26_msusceptibility to experimental allergic encephalomyelitis 26 (mouse)Not determined798164922132165010Mouse
26884451Sklq14_mskull length QTL 14, 16 week (mouse)767849748124999172Mouse
27095910Pglq13_mpelvic girdle length QTL 13, 16 week (mouse)773049748125699172Mouse
13463473Hbbcq4_mhemoglobin concentration QTL 4 (mouse)787043932121044066Mouse
11553869Stmm2b_mskin tumor modifier of MSM 2a (mouse)773725965107725965Mouse
27095907Scvln4_msacral vertebrae length 2, 5 week (mouse)769949748120499223Mouse
1301997Cia7_mcollagen induced arthritis QTL 7 (mouse)Not determined785365595112533819Mouse

Markers in Region
RH135897  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387102,094,604 - 102,094,814UniSTSGRCm38
MGSCv377109,243,118 - 109,243,328UniSTSGRCm37
Celera7102,461,659 - 102,461,869UniSTS
Cytogenetic Map7F1UniSTS
cM Map750.0UniSTS
Trpc2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387102,095,883 - 102,096,007UniSTSGRCm38
MGSCv377109,244,397 - 109,244,521UniSTSGRCm37
Celera7102,462,942 - 102,463,066UniSTS
Cytogenetic Map7F1UniSTS
cM Map750.0UniSTS
Trrp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387102,093,592 - 102,094,251UniSTSGRCm38
MGSCv377109,242,106 - 109,242,765UniSTSGRCm37
Celera7102,460,647 - 102,461,306UniSTS
Cytogenetic Map7F1UniSTS
cM Map750.0UniSTS
Trpc2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387102,088,247 - 102,089,129UniSTSGRCm38
MGSCv377109,236,761 - 109,237,643UniSTSGRCm37
Celera7102,455,320 - 102,456,202UniSTS
Cytogenetic Map7F1UniSTS
Trpc2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F1UniSTS
Trpc2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F1UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000124189   ⟹   ENSMUSP00000116934
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7101,732,323 - 101,745,603 (+)Ensembl
GRCm38.p6 Ensembl7102,083,116 - 102,096,396 (+)Ensembl
RefSeq Acc Id: NM_001109897   ⟹   NP_001103367
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397101,732,323 - 101,746,071 (+)NCBI
GRCm387102,083,116 - 102,096,864 (+)NCBI
MGSCv377109,214,227 - 109,244,930 (+)RGD
Celera7102,451,426 - 102,463,923 (+)NCBI
cM Map7 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001103367 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52700 (Get FASTA)   NCBI Sequence Viewer  
  AAG29951 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000116934
  ENSMUSP00000116934.3
GenBank Protein Q9R244 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001103367   ⟸   NM_001109897
- UniProtKB: Q9R244 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000116934   ⟸   ENSMUST00000124189
Protein Domains
DNA-repair protein Xrcc1 N-terminal   Ion transport

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R244-F1-model_v2 AlphaFold Q9R244 1-1172 view protein structure

Promoters
RGD ID:8665009
Promoter ID:EPDNEW_M10536
Type:single initiation site
Name:Trpc2_1
Description:Mus musculus transient receptor potential cation channel, subfamilyC, member 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387102,083,116 - 102,083,176EPDNEW
RGD ID:6841939
Promoter ID:MM_KWN:51815
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000084843,   ENSMUST00000089052,   ENSMUST00000094129,   ENSMUST00000106949,   ENSMUST00000106950,   OTTMUST00000054531,   OTTMUST00000054537,   OTTMUST00000054538,   OTTMUST00000054580,   OTTMUST00000054583,   OTTMUST00000054584,   OTTMUST00000054585,   UC009IQJ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367109,213,601 - 109,214,397 (-)MPROMDB
RGD ID:6842252
Promoter ID:MM_KWN:51820
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell,   Kidney
Transcripts:OTTMUST00000054540,   OTTMUST00000054541
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367109,229,151 - 109,229,907 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109527 AgrOrtholog
Ensembl Genes ENSMUSG00000066284
  ENSMUSG00000100254 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000124189 ENTREZGENE
  ENSMUST00000124189.3 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot
  Galactose-binding domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot
  Galactose-bd-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRP_dom UniProtKB/Swiss-Prot
  TRPC2_channel UniProtKB/Swiss-Prot
  TRPC_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Xrcc1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:22064 UniProtKB/Swiss-Prot
MGD MGI:109527 ENTREZGENE
NCBI Gene 22064 ENTREZGENE
PANTHER DNA-REPAIR PROTEIN XRCC1 UniProtKB/TrEMBL
  PTHR10117 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10117:SF6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  XRCC1_N DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRP_2 UniProtKB/Swiss-Prot
  XRCC1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Trpc2 PhenoGen
PRINTS TRNSRECEPTRP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRPCHANNEL2 UniProtKB/Swiss-Prot
SMART TRP_2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot
  SSF49785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Q61057_MOUSE UniProtKB/TrEMBL
  Q641L3_MOUSE UniProtKB/TrEMBL
  Q6J3R1_MOUSE UniProtKB/TrEMBL
  Q8CDC6_MOUSE UniProtKB/TrEMBL
  Q8CEM7_MOUSE UniProtKB/TrEMBL
  Q9R244 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q9ES59 UniProtKB/Swiss-Prot
  Q9ES60 UniProtKB/Swiss-Prot
  Q9R243 UniProtKB/Swiss-Prot