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Gene: TIMM10 (translocase of inner mitochondrial membrane 10) Homo sapiens

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Symbol:

TIMM10

Name:

translocase of inner mitochondrial membrane 10

RGD ID:

734114

HGNC Page

HGNC:11814

Description:

Enables membrane insertase activity; protein homodimerization activity; and protein-folding chaperone binding activity. Involved in protein insertion into mitochondrial inner membrane. Located in mitochondrial inner membrane and mitochondrial intermembrane space. Part of TIM22 mitochondrial import inner membrane insertion complex and mitochondrial intermembrane space protein transporter complex.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

mitochondrial import inner membrane translocase subunit Tim10; TIM10; TIM10A; TIMM10A; translocase of inner mitochondrial membrane 10 homolog; translocase of inner mitochondrial membrane 10 homolog (yeast)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	57,528,464 - 57,530,754 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	57,528,464 - 57,530,803 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	57,295,937 - 57,298,227 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	57,052,512 - 57,054,808 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	57,052,511 - 57,054,790	NCBI
Celera	11	54,652,463 - 54,654,751 (-)	NCBI		Celera
Cytogenetic Map	11	q12.1	NCBI
HuRef	11	53,644,725 - 53,647,021 (-)	NCBI		HuRef
CHM1_1	11	57,162,177 - 57,164,473 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	57,478,642 - 57,492,843 (-)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Animal Disease Models (EXP)

intellectual disability (IAGP)

lung adenocarcinoma (EXP)

rhabdomyosarcoma (EXP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-alpha-phellandrene (EXP)

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrotoluene (ISO)

2,6-dinitrotoluene (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

alpha-phellandrene (EXP)

ammonium chloride (ISO)

arsane (EXP)

arsenic atom (EXP)

atrazine (EXP)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (ISO)

bisphenol F (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

CGP 52608 (EXP)

cisplatin (EXP)

clobetasol (ISO)

cobalt dichloride (EXP)

cyclosporin A (ISO)

cypermethrin (ISO)

DDE (EXP)

Dibutyl phosphate (EXP)

dioxygen (ISO)

dorsomorphin (EXP)

endosulfan (ISO)

epoxiconazole (ISO)

ethanol (ISO)

finasteride (ISO)

flutamide (ISO)

folic acid (ISO)

ivermectin (EXP)

Mesaconitine (ISO)

nefazodone (ISO)

nimesulide (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

paraquat (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP)

pirinixic acid (ISO)

piroxicam (EXP)

progesterone (ISO)

propiconazole (ISO)

resveratrol (ISO)

SB 431542 (EXP)

sodium arsenite (EXP,ISO)

sulindac (ISO)

temozolomide (EXP)

testosterone (EXP)

tetrachloromethane (ISO)

thiram (EXP)

tolcapone (ISO)

toluene (ISO)

triphenyl phosphate (EXP)

tris(2-butoxyethyl) phosphate (EXP)

valproic acid (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

protein insertion into mitochondrial inner membrane (IBA,IDA,IEA,ISS,NAS)

protein targeting to mitochondrion (TAS)

protein transport (IEA)

sensory perception of sound (TAS)

Cellular Component

membrane (IEA)

mitochondrial inner membrane (IBA,IDA,IEA,TAS)

mitochondrial intermembrane space (IDA,NAS,TAS)

mitochondrial intermembrane space protein transporter complex (IDA,IEA,IPI)

mitochondrion (HTP,IDA,IEA)

TIM22 mitochondrial import inner membrane insertion complex (IPI)

TIM23 mitochondrial import inner membrane translocase complex (TAS)

Molecular Function

membrane insertase activity (IDA)

metal ion binding (IEA)

protein binding (IPI)

protein homodimerization activity (IPI)

protein-folding chaperone binding (IPI)

zinc ion binding (TAS)

Molecular Pathway Annotations Click to see Annotation Detail View

beta-barrel pathway of mitochondrial protein import (TAS)

carrier pathway of mitochondrial protein import (IDA)

Phenotype Annotations Click to see Annotation Detail View

Human Phenotype

Intellectual disability (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Assembly of beta-barrel proteins in the mitochondrial outer membrane.	Hohr AI, etal., Biochim Biophys Acta. 2015 Jan;1853(1):74-88. doi: 10.1016/j.bbamcr.2014.10.006. Epub 2014 Oct 8.
2.	Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria.	Muhlenbein N, etal., J Biol Chem. 2004 Apr 2;279(14):13540-6. Epub 2004 Jan 15.
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:9430585	PMID:10552927	PMID:10611480	PMID:11489896	PMID:12138093	PMID:12477932	PMID:12882976	PMID:15489334	PMID:16387659	PMID:16669873	PMID:16712791	PMID:16751776
PMID:18029348	PMID:19953087	PMID:20877624	PMID:21873635	PMID:22939629	PMID:22944692	PMID:23824909	PMID:26344197	PMID:27173435	PMID:28514442	PMID:28986522	PMID:29568061
PMID:30021884	PMID:30884312	PMID:31617661	PMID:31839598	PMID:32296183	PMID:32353859	PMID:32901109	PMID:33060197	PMID:33961781	PMID:34373451	PMID:34800366	PMID:35140242
PMID:35384245	PMID:35944360	PMID:38334954

Genomics

Comparative Map Data

TIMM10
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	57,528,464 - 57,530,754 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	57,528,464 - 57,530,803 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	57,295,937 - 57,298,227 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	57,052,512 - 57,054,808 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	57,052,511 - 57,054,790	NCBI
Celera	11	54,652,463 - 54,654,751 (-)	NCBI		Celera
Cytogenetic Map	11	q12.1	NCBI
HuRef	11	53,644,725 - 53,647,021 (-)	NCBI		HuRef
CHM1_1	11	57,162,177 - 57,164,473 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	57,478,642 - 57,492,843 (-)	NCBI		T2T-CHM13v2.0

Timm10
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	84,657,365 - 84,660,557 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	84,657,341 - 84,660,557 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	84,827,021 - 84,830,213 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	84,826,997 - 84,830,213 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	84,667,178 - 84,670,370 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	84,627,882 - 84,631,052 (+)	NCBI		MGSCv36	mm8
Celera	2	86,425,462 - 86,428,654 (+)	NCBI		Celera
Cytogenetic Map	2	D	NCBI
cM Map	2	49.45	NCBI

Timm10
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	90,315,048 - 90,318,613 (+)	NCBI		GRCr8
mRatBN7.2	3	69,908,397 - 69,911,943 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	69,908,456 - 69,911,940 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	73,290,091 - 73,293,533 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	81,888,758 - 81,892,200 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	79,647,735 - 79,651,165 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	72,226,563 - 72,230,087 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	72,226,613 - 72,230,084 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	78,747,501 - 78,751,016 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	68,036,888 - 68,040,362 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	67,933,259 - 67,936,731 (+)	NCBI
Celera	3	69,263,439 - 69,266,913 (+)	NCBI		Celera
Cytogenetic Map	3	q24	NCBI

Timm10
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955511	2,497,307 - 2,500,786 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955511	2,498,498 - 2,500,828 (-)	NCBI	ChiLan1.0	ChiLan1.0

TIMM10
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	58,684,939 - 58,687,272 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	59,702,013 - 59,704,346 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	52,769,429 - 52,771,763 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	56,241,079 - 56,243,361 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	56,241,078 - 56,243,351 (-)	Ensembl	panpan1.1		panPan2

TIMM10
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	38,638,277 - 38,641,623 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	38,638,696 - 38,641,623 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	38,184,397 - 38,187,748 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	39,320,287 - 39,323,638 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	39,320,707 - 39,323,634 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	38,902,862 - 38,906,207 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	38,476,461 - 38,479,815 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	39,106,918 - 39,110,270 (+)	NCBI		UU_Cfam_GSD_1.0

Timm10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	14,858,349 - 14,861,272 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936581	4,972,178 - 4,975,189 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936581	4,972,241 - 4,975,092 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TIMM10
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	13,393,282 - 13,396,439 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	13,393,225 - 13,396,241 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

TIMM10
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	15,701,586 - 15,703,867 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	15,701,469 - 15,703,900 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	113,053,475 - 113,056,303 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Timm10
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624864	3,127,286 - 3,129,773 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624864	3,127,282 - 3,129,773 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in TIMM10
6 total Variants

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 11q12.1(chr11:57372226-57936167)x3	copy number gain	See cases [RCV000051908]	Chr11:57372226..57936167 [GRCh38] Chr11:57139699..57703639 [GRCh37] Chr11:56896275..57460215 [NCBI36] Chr11:11q12.1	uncertain significance
GRCh38/hg38 11q11-12.1(chr11:55316535-57539457)x3	copy number gain	See cases [RCV000141200]	Chr11:55316535..57539457 [GRCh38] Chr11:55084011..57306930 [GRCh37] Chr11:54840587..57063506 [NCBI36] Chr11:11q11-12.1	uncertain significance
GRCh38/hg38 11q11-12.1(chr11:55319519-58998777)x3	copy number gain	See cases [RCV000142757]	Chr11:55319519..58998777 [GRCh38] Chr11:55086995..58766250 [GRCh37] Chr11:54843571..58522826 [NCBI36] Chr11:11q11-12.1	pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)	copy number gain	See cases [RCV000511729]	Chr11:230616..134938470 [GRCh37] Chr11:11p15.5-q25	pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3	copy number gain	See cases [RCV000510881]	Chr11:230616..134938470 [GRCh37] Chr11:11p15.5-q25	pathogenic
GRCh37/hg19 11p11.12-q12.1(chr11:49313405-59008426)x3	copy number gain	not provided [RCV000683370]	Chr11:49313405..59008426 [GRCh37] Chr11:11p11.12-q12.1	uncertain significance
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3	copy number gain	not provided [RCV000737348]	Chr11:198510..134934063 [GRCh37] Chr11:11p15.5-q25	pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3	copy number gain	not provided [RCV000749874]	Chr11:70864..134938470 [GRCh37] Chr11:11p15.5-q25	pathogenic
GRCh37/hg19 11q12.1(chr11:57147016-57667222)x3	copy number gain	not provided [RCV000750056]	Chr11:57147016..57667222 [GRCh37] Chr11:11q12.1	benign
Single allele	duplication	not provided [RCV000844966]	Chr11:55033164..57518726 [GRCh37] Chr11:11q11-12.1	not provided
Single allele	deletion	Intellectual disability [RCV001293382]	Chr11:118359328..118372573 [GRCh37] Chr11:11p15.3-q23.3	pathogenic
NC_000011.9:g.(?_57235082)_(57467503_?)del	deletion	not provided [RCV001390202]	Chr11:57235082..57467503 [GRCh37] Chr11:11q12.1	pathogenic
GRCh37/hg19 11q12.1(chr11:57112299-57871866)x3	copy number gain	not provided [RCV001825196]	Chr11:57112299..57871866 [GRCh37] Chr11:11q12.1	not provided
GRCh37/hg19 11q12.1(chr11:57037091-57453575)x3	copy number gain	not provided [RCV001829225]	Chr11:57037091..57453575 [GRCh37] Chr11:11q12.1	uncertain significance
GRCh37/hg19 11p13-q25(chr11:32799481-134938470)x3	copy number gain	MISSED ABORTION [RCV002282973]	Chr11:32799481..134938470 [GRCh37] Chr11:11p13-q25	pathogenic
GRCh37/hg19 11p11.2-q12.2(chr11:51581311-54891247)x3	copy number gain	See cases [RCV002286338]	Chr11:51581311..54891247 [GRCh37] Chr11:11p11.2-q12.2	pathogenic
GRCh37/hg19 11q12.1(chr11:56637024-57361915)x3	copy number gain	not provided [RCV002473570]	Chr11:56637024..57361915 [GRCh37] Chr11:11q12.1	uncertain significance
NM_012456.3(TIMM10):c.16G>T (p.Ala6Ser)	single nucleotide variant	not specified [RCV004215073]	Chr11:57530174 [GRCh38] Chr11:57297647 [GRCh37] Chr11:11q12.1	uncertain significance
NM_012456.3(TIMM10):c.242A>G (p.Lys81Arg)	single nucleotide variant	not specified [RCV004239084]	Chr11:57528748 [GRCh38] Chr11:57296221 [GRCh37] Chr11:11q12.1	uncertain significance
NM_012456.3(TIMM10):c.97T>C (p.Cys33Arg)	single nucleotide variant	not specified [RCV004113533]	Chr11:57528893 [GRCh38] Chr11:57296366 [GRCh37] Chr11:11q12.1	uncertain significance
GRCh37/hg19 11q12.1-13.3(chr11:56895955-69295402)x3	copy number gain	not specified [RCV003986944]	Chr11:56895955..69295402 [GRCh37] Chr11:11q12.1-13.3	likely pathogenic
GRCh37/hg19 11p11.12-q13.1(chr11:50398499-63924462)x3	copy number gain	not specified [RCV003986918]	Chr11:50398499..63924462 [GRCh37] Chr11:11p11.12-q13.1	likely pathogenic
GRCh37/hg19 11q12.1(chr11:57112299-57871866)x3	copy number gain	not specified [RCV003986941]	Chr11:57112299..57871866 [GRCh37] Chr11:11q12.1	uncertain significance
NM_012456.3(TIMM10):c.127C>T (p.Leu43Phe)	single nucleotide variant	not specified [RCV004469847]	Chr11:57528863 [GRCh38] Chr11:57296336 [GRCh37] Chr11:11q12.1	uncertain significance
NM_012456.3(TIMM10):c.92G>A (p.Arg31Gln)	single nucleotide variant	not specified [RCV004676961]	Chr11:57528898 [GRCh38] Chr11:57296371 [GRCh37] Chr11:11q12.1	uncertain significance
GRCh37/hg19 11q12.1(chr11:57003258-57596656)x3	copy number gain	Pontocerebellar hypoplasia type 10 [RCV004767746]	Chr11:57003258..57596656 [GRCh37] Chr11:11q12.1	likely pathogenic

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	787
Count of miRNA genes:	359
Interacting mature miRNAs:	389
Transcripts:	ENST00000257245, ENST00000525158, ENST00000525587
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region

RH80354

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	11	57,296,109 - 57,296,346	UniSTS	GRCh37
Build 36	11	57,052,685 - 57,052,922	RGD	NCBI36
Celera	11	54,652,628 - 54,652,865	RGD
Cytogenetic Map	11	q12.1-q12.3	UniSTS
HuRef	11	53,644,898 - 53,645,135	UniSTS

TIMM10_9493

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	11	57,295,837 - 57,296,356	UniSTS	GRCh37
Build 36	11	57,052,413 - 57,052,932	RGD	NCBI36
Celera	11	54,652,364 - 54,652,875	RGD
HuRef	11	53,644,626 - 53,645,145	UniSTS

RH45362

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	11	57,296,001 - 57,296,242	UniSTS	GRCh37
Build 36	11	57,052,577 - 57,052,818	RGD	NCBI36
Celera	11	54,652,520 - 54,652,761	RGD
Cytogenetic Map	11	q12.1-q12.3	UniSTS
HuRef	11	53,644,790 - 53,645,031	UniSTS
GeneMap99-GB4 RH Map	11	214.67	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	entire extraembryonic component	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	pharyngeal arch	renal system	reproductive system	respiratory system	sensory system	visual system
1204	2439	2788	2253	4974	1726	2351	6	624	1951	465	2270	7306	6472	53	3734	1	852	1744	1617	175	1

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_012456	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_024448436	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054368409	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054368410	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF150089	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF152354	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AI498204	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK289751	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AP002893	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC032133	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB106298	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471076	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068267	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ579709	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENST00000257245 ⟹ ENSP00000257245

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	11	57,528,464 - 57,530,754 (-)	Ensembl

Ensembl Acc Id:

ENST00000525158 ⟹ ENSP00000433627

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	11	57,528,641 - 57,530,734 (-)	Ensembl

Ensembl Acc Id:

ENST00000525587 ⟹ ENSP00000435678

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	11	57,528,626 - 57,530,803 (-)	Ensembl

RefSeq Acc Id:

NM_012456 ⟹ NP_036588

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	11	57,528,464 - 57,530,754 (-)	NCBI
GRCh37	11	57,295,936 - 57,298,232 (-)	RGD
Build 36	11	57,052,512 - 57,054,808 (-)	NCBI Archive
Celera	11	54,652,463 - 54,654,751 (-)	RGD
HuRef	11	53,644,725 - 53,647,021 (-)	RGD
CHM1_1	11	57,162,177 - 57,164,473 (-)	NCBI
T2T-CHM13v2.0	11	57,478,642 - 57,480,924 (-)	NCBI

Sequence:

show sequence

ACGTGCTTCCGCTGGAGCCTCTCGGGAGGCGGGTAACGTTATAGTATTTGTCAGAAGTTGGGGT
CTCCGTGGGCATTGTGATCCGTCCCAGGCAGTGGATTAGGAGGCCAGAAGGAGATCCCTTCCAC
GGTGCTAGGCTGAGATGGATCCTCTCAGGGCCCAACAGCTGGCTGCGGAGCTGGAGGTGGAGAT
GATGGCCGATATGTACAACAGAATGACCAGTGCCTGCCACCGGAAGTGTGTGCCTCCTCACTAC
AAGGAAGCAGAGCTCTCCAAGGGCGAGTCTGTGTGCCTGGACCGATGTGTCTCTAAGTACCTGG
ACATCCATGAGCGGATGGGCAAAAAGTTGACAGAGTTGTCTATGCAGGATGAAGAGCTGATGAA
GAGGGTGCAGCAGAGCTCTGGGCCTGCATGAGGTCCCTGTCAGTATACACCCTGGGGTGTACCC
CACCCCTTCCCACTTTAATAAACGTGCTCCCTGTTGGGTGTCATCTGTGAAGACTGCCAGGCCT
AGGCTCTCTGTAGAGAGTCTTCAAGATCCCGGAGTGGTAGCGCTGTCTCCTGGTGAAGGAGTAT
TTGTCACACTGGAATGTGACTGTGTGTGTATGTATGTGTATATATATATATATATATATATATA
TATATATAAACAAGTTTGTTGACACCTA

hide sequence

RefSeq Acc Id:

XM_024448436 ⟹ XP_024304204

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	11	57,528,464 - 57,530,754 (-)	NCBI

Sequence:

show sequence

ATCACGAAGGAGAGAGAAGTGCTTCCCCAAAGCTGGGATGGTTGGGCTACATTGACATGACGTT
GGATGGTGTTCACCTGATGCCCCTCGTGGGGAATGAGTGAATGGTGCAGTTTGAAGAACACATT
AAGTCTTGAAAGTTGGAAAGTTCACCAGTACCCTTCTTTCCCTCACCCAAGATTAGCCCTGGTG
GCAGCCGAAATTGCTTTTATTATCTCTTTGTGGCTGAGGACCTCTAACTGTTGAAGAAAACATA
TTTTACACGTCTTGTCTTTCTGCGAACAGGAAGCCTATCTCGCTTATCTTTGCAACCCCAGACG
GGGCTTAGTGTGACCTACACACAGCAGTAATCGCACAACGTCCCGTGGAGCACTGCTTCTCAAA
TTTGGCTGTACATACGAATCACCTGGGGAATTTTAAATTGTATTGCTGCCTGAGGAATTTTAAA
CTGTACTCCCAGAGATTCTGATTTAATTGAAATGAGGTGAGTCCTGGGCACTGGGATGTTTAAA
AACGTTCCAGGTGATTTTAACGCGAAACAAAAACAGAACCGCTGTTTGGGGGCGTTCTTCCTTC
TCCACGCCTGATTTGCGCACAGGAGTCGGCTGTCTGGAACGGGGGTGAGGTTCACAGGTGTCTG
TCGCCACGCCTCTTCCTACAGAACCAATAAACTGAAGCCGCTCGGTGACATCCCAAAGGACTTG
AATTCTGATCGGGCTGCAGACGCTCTGCACCCCGCCCAAGCTTCTATGGTACTTTGGTGTCCTC
TCTAGCACTGGCAAGTCGCCTTCCTCTTCGCCCGGCGCCAGCCGCTCCCTCTCTATGATCGCCG
AGTTCCCGGCGCCGTCTCGTTGGTATTTAATTCCGGAAGCGAGTTTGAATCAAAGAAGAGGCGG
GACTTTCCTCCCGGAAGTAACCCACGTGCTTCCGCTGGAGCCTCTCGGGAGGCGGGTAACGTTA
TAGTATTTGTCAGAAGTTGGGGTCTCCGTGGGCATTGTGATCCGTCCCAGGCAGTGCCCCAGGG
GTAGGAGAGTGAACGGCGGCGGTGGGTGCTGATGGTGATGTCTGCTCCCAGGATTAGGAGGCCA
GAAGGAGATCCCTTCCACGGTGCTAGGCTGAGATGGATCCTCTCAGGGCCCAACAGCTGGCTGC
GGAGCTGGAGGTGGAGATGATGGCCGATATGTACAACAGAATGACCAGTGCCTGCCACCGGAAG
TGTGTGCCTCCTCACTACAAGGAAGCAGAGCTCTCCAAGGGCGAGTCTGTGTGCCTGGACCGAT
GTGTCTCTAAGTACCTGGACATCCATGAGCGGATGGGCAAAAAGTTGACAGAGTTGTCTATGCA
GGATGAAGAGCTGATGAAGAGGGTGCAGCAGAGCTCTGGGCCTGCATGAGGTCCCTGTCAGTAT
ACACCCTGGGGTGTACCCCACCCCTTCCCACTTTAATAAACGTGCTCCCTGTTGGGTGTCATCT
GTGAA

hide sequence

RefSeq Acc Id:

XM_054368409 ⟹ XP_054224384

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
T2T-CHM13v2.0	11	57,478,642 - 57,492,832 (-)	NCBI

RefSeq Acc Id:

XM_054368410 ⟹ XP_054224385

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
T2T-CHM13v2.0	11	57,478,642 - 57,492,843 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_036588	(Get FASTA)	NCBI Sequence Viewer
	XP_024304204	(Get FASTA)	NCBI Sequence Viewer
	XP_054224384	(Get FASTA)	NCBI Sequence Viewer
	XP_054224385	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAD39995	(Get FASTA)	NCBI Sequence Viewer
	AAF15104	(Get FASTA)	NCBI Sequence Viewer
	AAH32133	(Get FASTA)	NCBI Sequence Viewer
	BAF82440	(Get FASTA)	NCBI Sequence Viewer
	EAW73753	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000257245
	ENSP00000257245.4
	ENSP00000433627
	ENSP00000433627.1
	ENSP00000435678.1
GenBank Protein	P62072	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_036588 ⟸ NM_012456
- UniProtKB:	Q9WVA0 (UniProtKB/Swiss-Prot), Q9WV99 (UniProtKB/Swiss-Prot), A8K136 (UniProtKB/Swiss-Prot), Q9Y5J8 (UniProtKB/Swiss-Prot), P62072 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MDPLRAQQLAAELEVEMMADMYNRMTSACHRKCVPPHYKEAELSKGESVCLDRCVSKYLDIHER MGKKLTELSMQDEELMKRVQQSSGPA hide sequence

RefSeq Acc Id:	XP_024304204 ⟸ XM_024448436
- Peptide Label:	isoform X1
- UniProtKB:	Q9WVA0 (UniProtKB/Swiss-Prot), Q9WV99 (UniProtKB/Swiss-Prot), P62072 (UniProtKB/Swiss-Prot), A8K136 (UniProtKB/Swiss-Prot), Q9Y5J8 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MDPLRAQQLAAELEVEMMADMYNRMTSACHRKCVPPHYKEAELSKGESVCLDRCVSKYLDIHER MGKKLTELSMQDEELMKRVQQSSGPA hide sequence

Ensembl Acc Id:

ENSP00000257245 ⟸ ENST00000257245

Ensembl Acc Id:

ENSP00000433627 ⟸ ENST00000525158

Ensembl Acc Id:

ENSP00000435678 ⟸ ENST00000525587

RefSeq Acc Id:	XP_054224385 ⟸ XM_054368410
- Peptide Label:	isoform X1
- UniProtKB:	Q9WVA0 (UniProtKB/Swiss-Prot), Q9WV99 (UniProtKB/Swiss-Prot), P62072 (UniProtKB/Swiss-Prot), A8K136 (UniProtKB/Swiss-Prot), Q9Y5J8 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_054224384 ⟸ XM_054368409
- Peptide Label:	isoform X1
- UniProtKB:	Q9WVA0 (UniProtKB/Swiss-Prot), Q9WV99 (UniProtKB/Swiss-Prot), P62072 (UniProtKB/Swiss-Prot), A8K136 (UniProtKB/Swiss-Prot), Q9Y5J8 (UniProtKB/Swiss-Prot)

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P62072-F1-model_v2	AlphaFold	P62072	1-90	view protein structure

Promoters

RGD ID:

6789433

Promoter ID:

HG_KWN:12927

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell, CD4+TCell_12Hour, CD4+TCell_2Hour, HeLa_S3, Jurkat, K562, Lymphoblastoid, NB4

Transcripts:

NM_012456

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	11	57,054,579 - 57,055,079 (-)	MPROMDB

RGD ID:

7220343

Promoter ID:

EPDNEW_H15917

Type:

initiation region

Name:

TIMM10_1

Description:

translocase of inner mitochondrial membrane 10

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	11	57,530,750 - 57,530,810	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:11814	AgrOrtholog
COSMIC	TIMM10	COSMIC
Ensembl Genes	ENSG00000134809	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENST00000257245	ENTREZGENE
	ENST00000257245.9	UniProtKB/Swiss-Prot
	ENST00000525158	ENTREZGENE
	ENST00000525158.1	UniProtKB/Swiss-Prot
	ENST00000525587.1	UniProtKB/Swiss-Prot
Gene3D-CATH	1.10.287.810	UniProtKB/Swiss-Prot
GTEx	ENSG00000134809	GTEx
HGNC ID	HGNC:11814	ENTREZGENE
Human Proteome Map	TIMM10	Human Proteome Map
InterPro	Tim10-like	UniProtKB/Swiss-Prot
	Tim10-like_dom_sf	UniProtKB/Swiss-Prot
KEGG Report	hsa:26519	UniProtKB/Swiss-Prot
NCBI Gene	26519	ENTREZGENE
OMIM	602251	OMIM
PANTHER	MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10	UniProtKB/Swiss-Prot
	PTHR11038:SF16	UniProtKB/Swiss-Prot
Pfam	zf-Tim10_DDP	UniProtKB/Swiss-Prot
PharmGKB	PA36521	PharmGKB
Superfamily-SCOP	SSF144122	UniProtKB/Swiss-Prot
UniProt	A8K136	ENTREZGENE
	P62072	ENTREZGENE
	Q9WV99	ENTREZGENE
	Q9WVA0	ENTREZGENE
	Q9Y5J8	ENTREZGENE
	TIM10_HUMAN	UniProtKB/Swiss-Prot
UniProt Secondary	A8K136	UniProtKB/Swiss-Prot
	Q9WV99	UniProtKB/Swiss-Prot
	Q9WVA0	UniProtKB/Swiss-Prot
	Q9Y5J8	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-10-04	TIMM10	translocase of inner mitochondrial membrane 10		translocase of inner mitochondrial membrane 10 homolog (yeast)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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