Ikbkb (inhibitor of kappaB kinase beta) - Rat Genome Database

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Gene: Ikbkb (inhibitor of kappaB kinase beta) Mus musculus
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Symbol: Ikbkb
Name: inhibitor of kappaB kinase beta
RGD ID: 733969
MGI Page MGI
Description: Enables IkappaB kinase activity and protein phosphatase binding activity. Involved in canonical NF-kappaB signal transduction; peptidyl-serine phosphorylation; and tumor necrosis factor-mediated signaling pathway. Acts upstream of or within several processes, including integrin-mediated signaling pathway; negative regulation of canonical NF-kappaB signal transduction; and positive regulation of monoatomic ion transport. Located in cytoplasmic side of plasma membrane. Part of CD40 receptor complex and IkappaB kinase complex. Is expressed in several structures, including cerebral cortex; genitourinary system; heart; and musculature. Used to study immunodeficiency 15A. Human ortholog(s) of this gene implicated in several diseases, including breast cancer; combined immunodeficiency (multiple); liver cancer; prostate cancer (multiple); and type 2 diabetes mellitus. Orthologous to human IKBKB (inhibitor of nuclear factor kappa B kinase subunit beta).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI132552; I-kappa-B kinase 2; I-kappa-B-kinase beta; IKK; IKK-; IKK-2; IKK-B; IKK-be; IKK-beta; IKK2; IKK2/beta; IKK[b; IKK[b]; IKKbe; IKKbeta; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; inhibitor of nuclear factor kappa-B kinase subunit beta; NFKBIKB; nuclear factor NF-kappa-B inhibitor kinase beta; serine/threonine protein kinase IKBKB
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39823,149,228 - 23,196,605 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl823,149,228 - 23,196,605 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38822,659,205 - 22,706,589 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl822,659,212 - 22,706,589 (-)Ensemblmm10GRCm38
MGSCv37823,769,677 - 23,817,055 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36824,125,308 - 24,172,108 (-)NCBIMGSCv36mm8
Celera824,149,472 - 24,196,863 (-)NCBICelera
Cytogenetic Map8A2NCBI
cM Map811.42NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (ISO)
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-colchicine  (EXP,ISO)
(S)-naringenin  (EXP)
1'-acetoxychavicol acetate  (ISO)
1,2-dimethylhydrazine  (EXP)
1,2-naphthoquinone  (EXP)
1,4-dithiothreitol  (EXP,ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-naphthyl isothiocyanate  (ISO)
15-oxo-ETE  (ISO)
17beta-estradiol  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-palmitoylglycerol  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-dihydroxybenzoic acid  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-vinylcyclohexene dioxide  (EXP)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (ISO)
[6]-Shogaol  (ISO)
abexinostat  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrolein  (ISO)
afatinib  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (EXP,ISO)
aldehydo-D-ribose  (EXP)
all-trans-retinoic acid  (ISO)
allopurinol  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (ISO)
Anemoside B4  (EXP)
anethole  (ISO)
aniline  (ISO)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimony(0)  (EXP)
apigenin  (EXP,ISO)
aristolochic acid A  (ISO)
arjunolic acid  (EXP)
Aroclor 1254  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenic trichloride  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (EXP)
Atractylodin  (EXP,ISO)
azadirachtin A  (ISO)
Azoxymethane  (EXP)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
beta-D-glucosamine  (EXP)
beta-D-glucosamine 6-sulfate  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (ISO)
bortezomib  (ISO)
butylated hydroxyanisole  (EXP)
butyric acid  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon atom  (ISO)
carbon nanotube  (EXP)
Carnosol  (ISO)
carvedilol  (ISO)
cefoxitin  (EXP)
cerium trichloride  (EXP)
chloroquine  (ISO)
chromium atom  (EXP)
chromium(6+)  (EXP)
chrysin  (ISO)
cisplatin  (EXP,ISO)
citalopram  (ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
curcumin  (EXP,ISO)
cytochalasin D  (ISO)
D-glucose  (EXP,ISO)
D-ribofuranose  (EXP)
deferiprone  (ISO)
dexamethasone  (EXP)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
dimercaprol  (ISO)
dimethyl fumarate  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
dipyridamole  (EXP)
doxorubicin  (ISO)
elemental carbon  (ISO)
elemental selenium  (EXP,ISO)
emamectin benzoate  (ISO)
endosulfan  (ISO)
enzyme inhibitor  (ISO)
escitalopram  (ISO)
ethanol  (EXP)
etoposide  (EXP,ISO)
eugenol  (ISO)
Evodiamine  (ISO)
farnesol  (EXP)
febuxostat  (ISO)
filipin III  (ISO)
flavonoids  (ISO)
fluorescein 5-isothiocyanate  (ISO)
folic acid  (EXP)
folpet  (EXP)
fructose  (ISO)
fulvestrant  (ISO)
Fusaric acid  (ISO)
gallic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP,ISO)
ginsenoside Re  (EXP)
glucose  (EXP,ISO)
glutathione  (EXP)
homoeriodictyol  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (EXP)
ibrutinib  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isorhapontigenin  (ISO)
JBIR-99  (ISO)
L-1,4-dithiothreitol  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
LY294002  (EXP,ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (ISO)
melittin  (EXP,ISO)
metformin  (ISO)
methapyrilene  (ISO)
methoxyacetic acid  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
metronidazole  (EXP)
miquelianin  (ISO)
Monobutylphthalate  (EXP,ISO)
monosodium L-glutamate  (EXP)
monotropein  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide  (EXP,ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP)
neratinib  (ISO)
nickel dichloride  (EXP,ISO)
niclosamide  (ISO)
nitroprusside  (EXP,ISO)
Nonylphenol  (ISO)
notoginsenoside R1  (EXP)
o-anisidine  (ISO)
okadaic acid  (ISO)
ozone  (EXP,ISO)
paclitaxel  (EXP,ISO)
Paeonol  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parthenolide  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (EXP)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
pifithrin-alpha hydrobromide  (ISO)
pioglitazone  (ISO)
platycodin D  (ISO)
Potassium 2,6-dihydroxytriazinecarboxylate  (EXP)
potassium chromate  (ISO)
progesterone  (EXP)
protein kinase inhibitor  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (EXP,ISO)
resiquimod  (ISO)
resveratrol  (EXP,ISO)
rocaglamide  (ISO)
rotenone  (ISO)
SB 203580  (EXP,ISO)
scutellarin  (EXP)
selenium atom  (EXP,ISO)
selenomethionine  (ISO)
silicon dioxide  (EXP)
simvastatin  (ISO)
sodium acetate trihydrate  (EXP)
sodium arsenite  (EXP,ISO)
sodium aurothiomalate  (EXP)
sodium propionate  (EXP)
Sodium salicylate  (EXP,ISO)
streptozocin  (EXP)
sulfasalazine  (ISO)
sulfur dioxide  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
taurine  (ISO)
testosterone  (ISO)
titanium dioxide  (EXP,ISO)
trans-anethole  (ISO)
Triptolide  (EXP,ISO)
triptonide  (EXP,ISO)
trovafloxacin  (EXP)
tungsten  (EXP)
umbelliferone  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
vincaleukoblastine  (ISO)
vorinostat  (ISO)
wedelolactone  (ISO)
wogonin  (EXP)
zerumbone  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
autophagy  (IDA)
B cell homeostasis  (IMP)
canonical NF-kappaB signal transduction  (IDA,IMP,ISO)
cellular response to tumor necrosis factor  (ISO,ISS)
I-kappaB phosphorylation  (TAS)
inflammatory response  (ISO)
integrin-mediated signaling pathway  (IDA,IEA)
interleukin-1-mediated signaling pathway  (ISO)
negative regulation of autophagy  (IDA)
negative regulation of bicellular tight junction assembly  (ISO)
negative regulation of canonical NF-kappaB signal transduction  (IDA,ISO)
negative regulation of cytokine production involved in inflammatory response  (ISO)
neuron projection development  (ISO)
non-canonical NF-kappaB signal transduction  (ISO)
peptidyl-serine phosphorylation  (IDA,ISO)
positive regulation of canonical NF-kappaB signal transduction  (IBA,ISO)
positive regulation of cation channel activity  (IGI)
positive regulation of cell population proliferation  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of sodium ion transport  (IGI)
positive regulation of transcription by RNA polymerase II  (IBA,ISO,ISS)
protein localization to plasma membrane  (ISO)
protein maturation  (ISO)
protein phosphorylation  (ISO)
protein polyubiquitination  (ISO)
regulation of establishment of endothelial barrier  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to cholecystokinin  (ISO)
response to fatty acid  (ISO)
response to lipopolysaccharide  (ISO)
response to toxic substance  (ISO)
response to xenobiotic stimulus  (ISO)
signal transduction involved in regulation of gene expression  (ISO)
skeletal muscle contraction  (ISO)
tumor necrosis factor-mediated signaling pathway  (IBA,IEA,IMP,ISO,TAS)

Cellular Component
CD40 receptor complex  (IDA,IEA)
cytoplasm  (IBA,IEA,ISO,TAS)
cytoplasmic side of plasma membrane  (IDA,IEA)
cytosol  (ISO)
IkappaB kinase complex  (IBA,IDA,IEA,IPI,ISO)
membrane  (IEA)
membrane raft  (IEA)
nucleus  (IEA)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal B cell activation  (IAGP)
abnormal B cell physiology  (IEA)
abnormal bile canaliculus morphology  (IAGP)
abnormal bile duct morphology  (IAGP)
abnormal CD8-positive, alpha-beta T cell differentiation  (IEA)
abnormal cell physiology  (IAGP)
abnormal dorsal root ganglion morphology  (IAGP)
abnormal effector T cell number  (IAGP)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal fibroblast migration  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal hindbrain morphology  (IAGP)
abnormal humoral immune response  (IAGP)
abnormal intestinal mucosa morphology  (IAGP)
abnormal myotube morphology  (IAGP)
abnormal neural fold elevation formation  (IAGP)
abnormal response to infection  (IEA)
abnormal response to injury  (IAGP)
abnormal T cell activation  (IAGP)
broad limb buds  (IAGP)
cachexia  (IAGP)
curly tail  (IAGP)
decreased acute inflammation  (IAGP)
decreased B cell number  (IAGP)
decreased B cell proliferation  (IAGP)
decreased B-1 B cell number  (IAGP)
decreased body weight  (IEA)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased central memory CD4-positive, alpha-beta T cell number  (IEA)
decreased circulating tumor necrosis factor level  (IAGP)
decreased fibroblast cell migration  (IAGP)
decreased fibroblast chemotaxis  (IAGP)
decreased follicular B cell number  (IAGP)
decreased IgE level  (IAGP)
decreased IgG level  (IAGP)
decreased IgM level  (IAGP)
decreased immature B cell number  (IAGP)
decreased interleukin-6 secretion  (IAGP)
decreased marginal zone B cell number  (IAGP)
decreased mature B cell number  (IAGP)
decreased memory B cell number  (IAGP)
decreased memory T cell number  (IAGP)
decreased regulatory T cell number  (IAGP)
decreased single-positive T cell number  (IAGP)
decreased survivor rate  (IAGP)
decreased T cell number  (IAGP)
dissociated hepatocytes  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
epidermal hyperplasia  (IAGP)
impaired macrophage chemotaxis  (IAGP)
impaired neutrophil chemotaxis  (IAGP)
impaired neutrophil recruitment  (IAGP)
increased B cell apoptosis  (IAGP)
increased B cell proliferation  (IAGP)
increased body weight  (IEA)
increased cellular sensitivity to gamma-irradiation  (IAGP)
increased circulating alanine transaminase level  (IAGP)
increased circulating bilirubin level  (IAGP)
increased embryonic neuroepithelium apoptosis  (IAGP)
increased enterocyte apoptosis  (IAGP)
increased fibroblast apoptosis  (IAGP)
increased hepatocyte apoptosis  (IAGP)
increased hindbrain apoptosis  (IAGP)
increased macrophage apoptosis  (IAGP)
increased regulatory T cell number  (IAGP)
increased response to antigen  (IEA)
increased skeletal muscle fiber number  (IAGP)
increased spinal cord apoptosis  (IAGP)
increased susceptibility to endotoxin shock  (IAGP)
increased susceptibility to viral infection  (IEA)
intestinal edema  (IAGP)
intrahepatic cholestasis  (IAGP)
jaundice  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
liver degeneration  (IAGP)
liver hemorrhage  (IAGP)
no abnormal phenotype detected  (IAGP)
open neural tube  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
preweaning lethality, incomplete penetrance  (IEA)
psoriasis  (IAGP)
skin inflammation  (IAGP)
skin lesions  (IAGP)
small embryonic telencephalon  (IAGP)
small liver  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Inflammatory related gene IKKα, IKKβ, IKKγ cooperates to determine liver cancer stem cells progression by altering telomere via heterochromatin protein 1-HOTAIR axis. An J, etal., Oncotarget. 2016 Aug 2;7(31):50131-50149. doi: 10.18632/oncotarget.10321.
2. Constitutive IKK2 activation in acinar cells is sufficient to induce pancreatitis in vivo. Baumann B, etal., J Clin Invest. 2007 Jun;117(6):1502-13. Epub 2007 May 24.
3. IKKbeta-dependent NF-kappaB pathway controls vascular inflammation and intimal hyperplasia. Bu DX, etal., FASEB J. 2005 Aug;19(10):1293-5. Epub 2005 Jun 6.
4. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Cai D, etal., Nat Med. 2005 Feb;11(2):183-90. Epub 2005 Jan 30.
5. Ischemic preconditioning attenuates renal ischemia-reperfusion injury by inhibiting activation of IKKbeta and inflammatory response. Chen X, etal., Am J Nephrol. 2009;30(3):287-94. doi: 10.1159/000225928. Epub 2009 Jun 16.
6. An NF-κB pathway-mediated positive feedback loop amplifies Ras activity to pathological levels in mice. Daniluk J, etal., J Clin Invest. 2012 Apr;122(4):1519-28. doi: 10.1172/JCI59743. Epub 2012 Mar 12.
7. Imidazo[4,5-d]thiazolo[5,4-b]pyridine based inhibitors of IKK2: synthesis, SAR, PK/PD and activity in a preclinical model of rheumatoid arthritis. Dyckman AJ, etal., Bioorg Med Chem Lett. 2011 Jan 1;21(1):383-6. doi: 10.1016/j.bmcl.2010.10.133. Epub 2010 Oct 31.
8. Glutamine inhibits over-expression of pro-inflammatory genes and down-regulates the nuclear factor kappaB pathway in an experimental model of colitis in the rat. Fillmann H, etal., Toxicology. 2007 Jul 17;236(3):217-26. Epub 2007 Apr 27.
9. Periodic, partial inhibition of IkappaB Kinase beta-mediated signaling yields therapeutic benefit in preclinical models of rheumatoid arthritis. Gillooly KM, etal., J Pharmacol Exp Ther. 2009 Nov;331(2):349-60. doi: 10.1124/jpet.109.156018. Epub 2009 Aug 3.
10. Heat treatment improves glucose tolerance and prevents skeletal muscle insulin resistance in rats fed a high-fat diet. Gupte AA, etal., Diabetes. 2009 Mar;58(3):567-78. doi: 10.2337/db08-1070. Epub 2008 Dec 10.
11. Shared principles in NF-kappaB signaling. Hayden MS and Ghosh S, Cell. 2008 Feb 8;132(3):344-62.
12. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Hayes JD and Dinkova-Kostova AT, Trends Biochem Sci. 2014 Apr;39(4):199-218. doi: 10.1016/j.tibs.2014.02.002. Epub 2014 Mar 16.
13. IKK mediates ischemia-induced neuronal death. Herrmann O, etal., Nat Med. 2005 Dec;11(12):1322-9. Epub 2005 Nov 13.
14. Elevated expression of tumor necrosis factor-alpha signaling molecules in colonic tumors of Zucker obese (fa/fa) rats. Jain SS and Bird RP, Int J Cancer. 2010 Nov 1;127(9):2042-50. doi: 10.1002/ijc.25232.
15. Experimental study on early protective effect of ischemic preconditioning on rat kidney graft. Jia RP, etal., Transplant Proc. 2009 Jan-Feb;41(1):69-72. doi: 10.1016/j.transproceed.2008.11.001.
16. Brain nuclear factor-kappa B activation contributes to neurohumoral excitation in angiotensin II-induced hypertension. Kang YM, etal., Cardiovasc Res. 2009 Jun 1;82(3):503-12. doi: 10.1093/cvr/cvp073. Epub 2009 Feb 25.
17. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
18. KrasG12D-induced IKK2/β/NF-κB activation by IL-1α and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma. Ling J, etal., Cancer Cell. 2012 Jan 17;21(1):105-20. doi: 10.1016/j.ccr.2011.12.006.
19. IKK2 inhibition attenuates laser-induced choroidal neovascularization. Lu H, etal., PLoS One. 2014 Jan 28;9(1):e87530. doi: 10.1371/journal.pone.0087530. eCollection 2014.
20. Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice. Maniati E, etal., J Clin Invest. 2011 Dec;121(12):4685-99. doi: 10.1172/JCI45797. Epub 2011 Nov 7.
21. Acetylpuerarin reduces inflammation and improves memory function in a rat model of Alzheimer's disease induced by Abeta1-42. Meng QH, etal., Pharmazie. 2013 Nov;68(11):904-8.
22. MGDs mouse GO annotations MGD data from the GO Consortium
23. MGD IEA MGD IEA
24. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
25. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
26. Donor antigen-loaded IKK2dn gene-modified dendritic cells prolong allograft survival. Ouyang J, etal., Scand J Immunol. 2010 May;71(5):336-44.
27. IKKbeta leads to an inflammatory skin disease resembling interface dermatitis. Page A, etal., J Invest Dermatol. 2010 Jun;130(6):1598-610. doi: 10.1038/jid.2010.28. Epub 2010 Mar 4.
28. TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2. Pasparakis M, etal., Nature. 2002 Jun 20;417(6891):861-6.
29. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
30. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
31. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
32. [Influence of electroacupuncture intervention on hippocampal IL-1beta content and I kappa B kinase beta expression in focal cerebral ischemia/reperfusion rats]. Qin WY, etal., Zhen Ci Yan Jiu. 2013 Aug;38(4):271-6.
33. Anti-inflammatory effect of a selective IkappaB kinase-beta inhibitor in rat lung in response to LPS and cigarette smoke. Rajendrasozhan S, etal., Pulm Pharmacol Ther. 2010 Jun;23(3):172-81. doi: 10.1016/j.pupt.2010.01.002. Epub 2010 Jan 18.
34. Mouse MP Annotation Import Pipeline RGD automated import pipeline
35. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
36. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
37. Xanthine oxidase-induced oxidative stress causes activation of NF-kappaB and inflammation in the liver of type I diabetic rats. Romagnoli M, etal., Free Radic Biol Med. 2010 Jul 15;49(2):171-7. doi: 10.1016/j.freeradbiomed.2010.03.024. Epub 2010 Mar 31.
38. Apigenin blocks IKKa activation and suppresses prostate cancer progression. Shukla S, etal., Oncotarget. 2015 Oct 13;6(31):31216-32. doi: 10.18632/oncotarget.5157.
39. Genetic variation in genes involved in hormones, inflammation, and energetic factors and breast cancer risk in an admixed population. Slattery M, etal., Carcinogenesis. 2012 May 4.
40. Localized inflammatory skin disease following inducible ablation of I kappa B kinase 2 in murine epidermis. Stratis A, etal., J Invest Dermatol. 2006 Mar;126(3):614-20.
41. The IkappaB kinases IKKalpha and IKKbeta are necessary and sufficient for skeletal muscle atrophy. Van Gammeren D, etal., FASEB J. 2009 Feb;23(2):362-70. doi: 10.1096/fj.08-114249. Epub 2008 Sep 30.
42. Tumor necrosis factor signaling. Wajant H, etal., Cell Death Differ. 2003 Jan;10(1):45-65.
43. Novel tricyclic inhibitors of IKK2: discovery and SAR leading to the identification of 2-methoxy-N-((6-(1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b] pyridin-7-yl)pyridin-2-yl)methyl)acetamide (BMS-066). Watterson SH, etal., Bioorg Med Chem Lett. 2011 Dec 1;21(23):7006-12. doi: 10.1016/j.bmcl.2011.09.111. Epub 2011 Oct 5.
44. Molecular determinants of melanoma malignancy: selecting targets for improved efficacy of chemotherapy. Yang J, etal., Mol Cancer Ther. 2009 Mar;8(3):636-47. doi: 10.1158/1535-7163.MCT-08-0749. Epub 2009 Mar 10.
45. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Yuan M, etal., Science. 2001 Aug 31;293(5535):1673-7.
46. Targeting I¿B Kinase ß/NF-¿B Signaling in Human Prostate Cancer by a Novel I¿B Kinase ß Inhibitor CmpdA. Zhang Y, etal., Mol Cancer Ther. 2016 Jul;15(7):1504-14. doi: 10.1158/1535-7163.MCT-15-0999. Epub 2016 Apr 8.
Additional References at PubMed
PMID:7590248   PMID:7963540   PMID:8889548   PMID:9520401   PMID:9597130   PMID:9813230   PMID:9819420   PMID:10072378   PMID:10195895   PMID:10195896   PMID:10195897   PMID:10229185  
PMID:10232975   PMID:10349636   PMID:10359587   PMID:10373503   PMID:10523828   PMID:10523854   PMID:10593965   PMID:10748240   PMID:10898787   PMID:10922068   PMID:11042159   PMID:11076861  
PMID:11290332   PMID:11694538   PMID:11713531   PMID:11777949   PMID:11918218   PMID:11937522   PMID:12070292   PMID:12202685   PMID:12221085   PMID:12235208   PMID:12477932   PMID:12520002  
PMID:12668256   PMID:12692538   PMID:12707341   PMID:12759443   PMID:12808104   PMID:12842894   PMID:14499113   PMID:14500727   PMID:14561702   PMID:14585846   PMID:14610273   PMID:14614859  
PMID:14654787   PMID:14660645   PMID:14741691   PMID:14755344   PMID:14960276   PMID:14963024   PMID:14963119   PMID:14966265   PMID:14978074   PMID:14983030   PMID:15021910   PMID:15029200  
PMID:15070758   PMID:15084260   PMID:15102471   PMID:15148408   PMID:15199157   PMID:15252035   PMID:15265889   PMID:15292220   PMID:15294155   PMID:15355979   PMID:15479644   PMID:15564469  
PMID:15611068   PMID:15684432   PMID:15685170   PMID:15692052   PMID:15721278   PMID:15746257   PMID:15761153   PMID:15776110   PMID:15778223   PMID:15782199   PMID:15790681   PMID:15829915  
PMID:15897281   PMID:15905851   PMID:15919917   PMID:15951441   PMID:15989949   PMID:16046471   PMID:16123045   PMID:16126728   PMID:16141072   PMID:16141073   PMID:16169504   PMID:16260493  
PMID:16291755   PMID:16306937   PMID:16317067   PMID:16319058   PMID:16378096   PMID:16413924   PMID:16469705   PMID:16498412   PMID:16547522   PMID:16602821   PMID:16612387   PMID:16775250  
PMID:16807293   PMID:16818780   PMID:16886058   PMID:16887827   PMID:16892069   PMID:16916935   PMID:16935850   PMID:16966325   PMID:17041603   PMID:17080195   PMID:17116751   PMID:17118453  
PMID:17123945   PMID:17151194   PMID:17204585   PMID:17237423   PMID:17244613   PMID:17267600   PMID:17292824   PMID:17322906   PMID:17361131   PMID:17380205   PMID:17429444   PMID:17526490  
PMID:17570221   PMID:17579036   PMID:17616684   PMID:17675566   PMID:17690092   PMID:17698569   PMID:17803913   PMID:17827258   PMID:17939994   PMID:17954568   PMID:17970697   PMID:18000063  
PMID:18216269   PMID:18240344   PMID:18266467   PMID:18287559   PMID:18299349   PMID:18308615   PMID:18316610   PMID:18321726   PMID:18391940   PMID:18393321   PMID:18432192   PMID:18490491  
PMID:18490760   PMID:18508047   PMID:18541671   PMID:18542057   PMID:18567579   PMID:18573490   PMID:18606991   PMID:18635759   PMID:18682563   PMID:18691550   PMID:18692471   PMID:18701687  
PMID:18704119   PMID:18755269   PMID:18815378   PMID:18816823   PMID:18819987   PMID:18854155   PMID:18949383   PMID:18952604   PMID:18981174   PMID:19136968   PMID:19150425   PMID:19171122  
PMID:19196987   PMID:19201871   PMID:19202066   PMID:19363130   PMID:19412180   PMID:19478205   PMID:19488402   PMID:19500387   PMID:19524538   PMID:19734906   PMID:19786027   PMID:19796012  
PMID:19821485   PMID:19828806   PMID:19897484   PMID:19959994   PMID:19962981   PMID:20007573   PMID:20007767   PMID:20018862   PMID:20080131   PMID:20097762   PMID:20129250   PMID:20195534  
PMID:20200955   PMID:20211142   PMID:20220849   PMID:20227042   PMID:20231695   PMID:20347815   PMID:20389019   PMID:20404153   PMID:20434986   PMID:20448200   PMID:20494824   PMID:20522742  
PMID:20530876   PMID:20534585   PMID:20569972   PMID:20600852   PMID:20614026   PMID:20622870   PMID:20637660   PMID:20657549   PMID:20671747   PMID:20686657   PMID:20797629   PMID:20814569  
PMID:20921405   PMID:20930169   PMID:21098220   PMID:21152019   PMID:21156282   PMID:21170027   PMID:21264230   PMID:21267068   PMID:21293322   PMID:21356358   PMID:21357939   PMID:21464320  
PMID:21465579   PMID:21469085   PMID:21490922   PMID:21533069   PMID:21537326   PMID:21576359   PMID:21587235   PMID:21606193   PMID:21642978   PMID:21677750   PMID:21701067   PMID:21728169  
PMID:21765415   PMID:21775686   PMID:21784844   PMID:21804564   PMID:21862579   PMID:21873635   PMID:21895414   PMID:21983082   PMID:21983962   PMID:21985298   PMID:21997190   PMID:22022477  
PMID:22037600   PMID:22067324   PMID:22147015   PMID:22161279   PMID:22169952   PMID:22227519   PMID:22253230   PMID:22301546   PMID:22327365   PMID:22343279   PMID:22363815   PMID:22464396  
PMID:22484734   PMID:22511786   PMID:22514330   PMID:22564672   PMID:22633953   PMID:22637744   PMID:22685314   PMID:22685599   PMID:22750522   PMID:22753500   PMID:22753932   PMID:22833419  
PMID:22836752   PMID:22848663   PMID:22893683   PMID:22915098   PMID:22940906   PMID:22988300   PMID:23011799   PMID:23023371   PMID:23241410   PMID:23273920   PMID:23296707   PMID:23332762  
PMID:23349802   PMID:23349803   PMID:23555249   PMID:23563311   PMID:23563314   PMID:23613522   PMID:23636330   PMID:23665348   PMID:23686246   PMID:23690607   PMID:23761888   PMID:23776175  
PMID:23817200   PMID:23825957   PMID:23839064   PMID:23871670   PMID:23939348   PMID:23960234   PMID:24023826   PMID:24078701   PMID:24084740   PMID:24119288   PMID:24211183   PMID:24240172  
PMID:24266532   PMID:24270572   PMID:24292713   PMID:24296718   PMID:24319055   PMID:24345681   PMID:24469399   PMID:24489962   PMID:24550492   PMID:24586253   PMID:24618907   PMID:24667561  
PMID:24683189   PMID:24747690   PMID:24751519   PMID:24792914   PMID:24799533   PMID:24832470   PMID:24882009   PMID:24911653   PMID:24912162   PMID:24993069   PMID:25057006   PMID:25132496  
PMID:25172655   PMID:25176657   PMID:25253847   PMID:25267645   PMID:25297800   PMID:25314080   PMID:25325922   PMID:25326420   PMID:25336190   PMID:25355930   PMID:25358444   PMID:25376721  
PMID:25456138   PMID:25466256   PMID:25526093   PMID:25563500   PMID:25606824   PMID:25648675   PMID:25652452   PMID:25694610   PMID:25891078   PMID:25968264   PMID:26102347   PMID:26260587  
PMID:26347470   PMID:26353931   PMID:26371187   PMID:26377563   PMID:26378659   PMID:26494620   PMID:26539991   PMID:26621452   PMID:26621453   PMID:26649818   PMID:26669856   PMID:26824076  
PMID:26968344   PMID:26987064   PMID:26991836   PMID:26993069   PMID:27058114   PMID:27060662   PMID:27099294   PMID:27320908   PMID:27387502   PMID:27450563   PMID:27582100   PMID:27605009  
PMID:27814504   PMID:27822501   PMID:28017612   PMID:28017833   PMID:28060857   PMID:28185240   PMID:28190767   PMID:28193238   PMID:28214532   PMID:28377875   PMID:28378742   PMID:28438992  
PMID:28467927   PMID:28480888   PMID:28584022   PMID:28683286   PMID:28725915   PMID:28797077   PMID:28883017   PMID:29036520   PMID:29045828   PMID:29203883   PMID:29249691   PMID:29301759  
PMID:29367460   PMID:29386112   PMID:29434332   PMID:29576482   PMID:29588349   PMID:29595073   PMID:29649481   PMID:29891719   PMID:29935185   PMID:29975753   PMID:29993183   PMID:30043530  
PMID:30131424   PMID:30143619   PMID:30214937   PMID:30285578   PMID:30335863   PMID:30337470   PMID:30463808   PMID:30737145   PMID:30755793   PMID:30818064   PMID:30887211   PMID:30973865  
PMID:30982734   PMID:30988283   PMID:31086261   PMID:31088970   PMID:31439641   PMID:31481750   PMID:31488203   PMID:31552024   PMID:31618063   PMID:31792060   PMID:31826938   PMID:31893948  
PMID:31903163   PMID:31989218   PMID:32117051   PMID:32130954   PMID:32294437   PMID:32325033   PMID:32434410   PMID:32554809   PMID:32711212   PMID:32857851   PMID:32968282   PMID:32978373  
PMID:33119032   PMID:33414459   PMID:33658989   PMID:33851975   PMID:33913480   PMID:34062371   PMID:34091985   PMID:34145059   PMID:34244313   PMID:34311141   PMID:34321999   PMID:34324438  
PMID:34454938   PMID:34565380   PMID:34626855   PMID:34685649   PMID:35083662   PMID:35145063   PMID:35146388   PMID:35401811   PMID:35413950   PMID:35597154   PMID:35626041   PMID:35810590  
PMID:36001064   PMID:36077596   PMID:36145208   PMID:36265554   PMID:36508247   PMID:36584405   PMID:36610396   PMID:36688823   PMID:36812915   PMID:36896602   PMID:36923932   PMID:36980752  
PMID:37199240   PMID:37283745   PMID:37310763   PMID:37329888   PMID:37402711   PMID:37566034   PMID:37572666   PMID:37611729   PMID:37902166   PMID:38197897   PMID:38279130   PMID:38355793  
PMID:38461418   PMID:38470493   PMID:38528069   PMID:39122678   PMID:39365876   PMID:39475511   PMID:39862865   PMID:40532025  


Genomics

Comparative Map Data
Ikbkb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39823,149,228 - 23,196,605 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl823,149,228 - 23,196,605 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38822,659,205 - 22,706,589 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl822,659,212 - 22,706,589 (-)Ensemblmm10GRCm38
MGSCv37823,769,677 - 23,817,055 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36824,125,308 - 24,172,108 (-)NCBIMGSCv36mm8
Celera824,149,472 - 24,196,863 (-)NCBICelera
Cytogenetic Map8A2NCBI
cM Map811.42NCBI
IKBKB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38842,271,302 - 42,332,460 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl842,271,302 - 42,332,460 (+)Ensemblhg38GRCh38
GRCh37842,128,820 - 42,189,978 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36842,247,986 - 42,309,122 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34842,247,985 - 42,309,122NCBI
Celera841,077,798 - 41,138,835 (+)NCBICelera
Cytogenetic Map8p11.21NCBI
HuRef840,656,604 - 40,717,697 (+)NCBIHuRef
CHM1_1842,177,451 - 42,238,764 (+)NCBICHM1_1
T2T-CHM13v2.0842,545,654 - 42,606,501 (+)NCBIT2T-CHM13v2.0
Ikbkb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81676,021,968 - 76,075,717 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1676,022,008 - 76,081,911 (+)EnsemblGRCr8
mRatBN7.21669,319,487 - 69,373,251 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1669,319,554 - 69,373,250 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1674,593,277 - 74,646,961 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01678,025,765 - 78,078,546 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01673,274,913 - 73,327,717 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01674,177,233 - 74,230,809 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1674,177,215 - 74,230,815 (+)Ensemblrn6Rnor6.0
Rnor_5.01673,809,854 - 73,863,636 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41673,804,730 - 73,858,510 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1667,214,025 - 67,266,348 (+)NCBICelera
RGSC_v3.11673,805,346 - 73,858,348 (+)NCBI
Cytogenetic Map16q12.5NCBI
Ikbkb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955536612,774 - 658,647 (-)Ensembl
ChiLan1.0NW_004955536611,965 - 658,647 (-)NCBIChiLan1.0ChiLan1.0
IKBKB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2760,723,875 - 60,784,734 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1836,441,096 - 36,501,335 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0841,515,613 - 41,576,229 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1838,960,594 - 39,020,971 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl838,960,594 - 39,020,971 (+)EnsemblpanPan2panpan1.1
IKBKB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11623,359,551 - 23,419,114 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1623,359,813 - 23,419,075 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1623,864,109 - 23,923,669 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01625,108,158 - 25,167,347 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1625,108,158 - 25,167,336 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11623,479,268 - 23,538,442 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01624,042,615 - 24,101,962 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01624,093,332 - 24,152,694 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ikbkb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494346,401,726 - 46,450,359 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936785356,168 - 406,773 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936785358,128 - 406,751 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IKBKB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1711,289,690 - 11,348,549 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11711,289,607 - 11,348,557 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21713,063,170 - 13,101,270 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IKBKB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1840,267,532 - 40,325,282 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl840,268,079 - 40,326,381 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660521,461,878 - 1,520,432 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ikbkb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624780923,744 - 970,519 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624780922,524 - 978,687 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Ikbkb
3851 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:4007
Count of miRNA genes:896
Interacting mature miRNAs:1206
Transcripts:ENSMUST00000033939, ENSMUST00000063401, ENSMUST00000125314, ENSMUST00000126439, ENSMUST00000126496, ENSMUST00000131767, ENSMUST00000132279, ENSMUST00000135326, ENSMUST00000144583, ENSMUST00000144895, ENSMUST00000146212, ENSMUST00000149093, ENSMUST00000150214, ENSMUST00000150259
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357525Pnhdlc3_mplasma non-HDL cholesterol 3 (mouse)Not determined8721249923753815Mouse
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81477316071498244Mouse
1301298Pgia4_mproteoglycan induced arthritis 4 (mouse)Not determined81656937350569697Mouse
1300912Daq19_mdirectional asymmetry QTL 19 (mouse)Not determined81550657249506729Mouse
11532713Sluc42_msusceptibility to lung cancer 42 (mouse)81344721035321225Mouse
4142199Poats1_mpost-ovarectomy adrenal tumor susceptibility 1 (mouse)Not determined1708262628849467Mouse
1300603Cd8ts2_mCD8 T cell subset 2 (mouse)Not determined81945501853455150Mouse
4140978Nilac5_mnicotine induced locomotor activity 5 (mouse)Not determined8131773288Mouse
1301532Scc8_mcolon tumor susceptibility 8 (mouse)Not determined8721249935110107Mouse
10412209Cypr7_mcytokine production 7 (mouse)Not determined8810320142103372Mouse
1301088Alcw6_malcohol withdrawal 6 (mouse)Not determined81550657249506729Mouse
11533914Mts5_mmammary tumor susceptibility 5 (mouse)8130447432Mouse
13432571Scvg1_msubcutaneous vessel growth QTL 1 (mouse)8124751082Mouse
1300906Ap8q_malcohol preference 8 QTL (mouse)Not determined8798418941984342Mouse
1301929Eae24_msusceptibility to experimental allergic encephalomyelitis 24 (mouse)Not determined8810320142103372Mouse
27226756Femd2_mfemur midshaft diameter 2, 5 week (mouse)8495000035067154Mouse
1301128Sluc20_msusceptibility to lung cancer 20 (mouse)Not determined8810320142103372Mouse
1301160Eae14_msusceptibility to experimental allergic encephalomyelitis 14 (mouse)Not determined81945501853455150Mouse
1301550Fembrs2_mfemur breaking strength 2 (mouse)Not determined81832109752321225Mouse

Markers in Region
AI132552  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38822,659,335 - 22,659,621UniSTSGRCm38
MGSCv37823,769,807 - 23,770,093UniSTSGRCm37
Celera824,149,602 - 24,149,888UniSTS
Cytogenetic Map8A3-A4UniSTS
Whitehead/MRC_RH8261.26UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001159774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001424830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001424831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001424832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_188955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_188956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_188957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_188958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_188959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006509022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036153764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA203913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC121835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF026524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF088910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK003927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK051128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK053346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK086442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK139972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK156294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK177348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK182153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK201390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC004772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC019210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC020334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC037723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY015258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000033939   ⟹   ENSMUSP00000033939
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl823,149,228 - 23,196,594 (-)Ensembl
GRCm38.p6 Ensembl822,659,212 - 22,706,578 (-)Ensembl
Ensembl Acc Id: ENSMUST00000063401   ⟹   ENSMUSP00000064235
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl823,149,784 - 23,196,605 (-)Ensembl
GRCm38.p6 Ensembl822,659,768 - 22,706,589 (-)Ensembl
Ensembl Acc Id: ENSMUST00000125314   ⟹   ENSMUSP00000138156
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl823,149,229 - 23,196,556 (-)Ensembl
GRCm38.p6 Ensembl822,659,213 - 22,706,540 (-)Ensembl
Ensembl Acc Id: ENSMUST00000126439
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl823,181,856 - 23,196,590 (-)Ensembl
GRCm38.p6 Ensembl822,691,840 - 22,706,574 (-)Ensembl
Ensembl Acc Id: ENSMUST00000126496
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl823,158,027 - 23,159,042 (-)Ensembl
GRCm38.p6 Ensembl822,668,011 - 22,669,026 (-)Ensembl
Ensembl Acc Id: ENSMUST00000131767   ⟹   ENSMUSP00000120916
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl823,172,773 - 23,184,081 (-)Ensembl
GRCm38.p6 Ensembl822,682,757 - 22,694,065 (-)Ensembl
Ensembl Acc Id: ENSMUST00000132279   ⟹   ENSMUSP00000120049
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl823,150,124 - 23,151,498 (-)Ensembl
GRCm38.p6 Ensembl822,660,108 - 22,661,482 (-)Ensembl
Ensembl Acc Id: ENSMUST00000135326   ⟹   ENSMUSP00000138378
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl823,149,229 - 23,196,550 (-)Ensembl
GRCm38.p6 Ensembl822,659,213 - 22,706,534 (-)Ensembl
Ensembl Acc Id: ENSMUST00000144583
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl823,171,228 - 23,196,555 (-)Ensembl
GRCm38.p6 Ensembl822,681,212 - 22,706,539 (-)Ensembl
Ensembl Acc Id: ENSMUST00000144895
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl823,179,147 - 23,196,575 (-)Ensembl
GRCm38.p6 Ensembl822,689,131 - 22,706,559 (-)Ensembl
Ensembl Acc Id: ENSMUST00000146212
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl823,150,373 - 23,196,594 (-)Ensembl
GRCm38.p6 Ensembl822,660,357 - 22,706,578 (-)Ensembl
Ensembl Acc Id: ENSMUST00000149093
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl823,192,024 - 23,196,579 (-)Ensembl
GRCm38.p6 Ensembl822,702,008 - 22,706,563 (-)Ensembl
Ensembl Acc Id: ENSMUST00000150214
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl823,192,468 - 23,196,541 (-)Ensembl
GRCm38.p6 Ensembl822,702,452 - 22,706,525 (-)Ensembl
Ensembl Acc Id: ENSMUST00000150259
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl823,166,000 - 23,196,556 (-)Ensembl
GRCm38.p6 Ensembl822,675,984 - 22,706,540 (-)Ensembl
RefSeq Acc Id: NM_001159774   ⟹   NP_001153246
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39823,149,228 - 23,196,575 (-)NCBI
GRCm38822,659,205 - 22,706,583 (-)NCBI
MGSCv37823,769,677 - 23,817,055 (-)RGD
Celera824,149,472 - 24,196,863 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001424830   ⟹   NP_001411759
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39823,149,228 - 23,196,575 (-)NCBI
RefSeq Acc Id: NM_001424831   ⟹   NP_001411760
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39823,149,228 - 23,196,575 (-)NCBI
RefSeq Acc Id: NM_001424832   ⟹   NP_001411761
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39823,149,228 - 23,196,575 (-)NCBI
RefSeq Acc Id: NM_010546   ⟹   NP_034676
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39823,149,228 - 23,196,575 (-)NCBI
GRCm38822,659,205 - 22,706,583 (-)NCBI
MGSCv37823,769,677 - 23,817,055 (-)RGD
Celera824,149,472 - 24,196,863 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_188955
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39823,149,228 - 23,196,575 (-)NCBI
RefSeq Acc Id: NR_188956
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39823,149,228 - 23,196,575 (-)NCBI
RefSeq Acc Id: NR_188957
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39823,149,228 - 23,196,575 (-)NCBI
RefSeq Acc Id: NR_188958
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39823,149,228 - 23,196,575 (-)NCBI
RefSeq Acc Id: NR_188959
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39823,149,228 - 23,196,575 (-)NCBI
RefSeq Acc Id: XM_006509022   ⟹   XP_006509085
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39823,157,300 - 23,196,605 (-)NCBI
GRCm38822,667,298 - 22,706,589 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036153764   ⟹   XP_036009657
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39823,149,239 - 23,196,596 (-)NCBI
Sequence:
RefSeq Acc Id: NP_034676   ⟸   NM_010546
- Peptide Label: isoform 2
- UniProtKB: Q9R1J6 (UniProtKB/Swiss-Prot),   O88351 (UniProtKB/Swiss-Prot),   A0A0R4J0T4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001153246   ⟸   NM_001159774
- Peptide Label: isoform 1
- UniProtKB: Q9R1J6 (UniProtKB/Swiss-Prot),   O88351 (UniProtKB/Swiss-Prot),   Q5D0E0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006509085   ⟸   XM_006509022
- Peptide Label: isoform X3
- Sequence:
Ensembl Acc Id: ENSMUSP00000138156   ⟸   ENSMUST00000125314
Ensembl Acc Id: ENSMUSP00000120049   ⟸   ENSMUST00000132279
Ensembl Acc Id: ENSMUSP00000120916   ⟸   ENSMUST00000131767
Ensembl Acc Id: ENSMUSP00000033939   ⟸   ENSMUST00000033939
Ensembl Acc Id: ENSMUSP00000138378   ⟸   ENSMUST00000135326
Ensembl Acc Id: ENSMUSP00000064235   ⟸   ENSMUST00000063401
RefSeq Acc Id: XP_036009657   ⟸   XM_036153764
- Peptide Label: isoform X4
RefSeq Acc Id: NP_001411761   ⟸   NM_001424832
- Peptide Label: isoform 5
RefSeq Acc Id: NP_001411760   ⟸   NM_001424831
- Peptide Label: isoform 4
- UniProtKB: Q05DR8 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001411759   ⟸   NM_001424830
- Peptide Label: isoform 3
- UniProtKB: Q9R1J6 (UniProtKB/Swiss-Prot),   O88351 (UniProtKB/Swiss-Prot)
Protein Domains
I-kappa-kinase-beta NEMO binding   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88351-F1-model_v2 AlphaFold O88351 1-757 view protein structure

Promoters
RGD ID:8666689
Promoter ID:EPDNEW_M11376
Type:initiation region
Name:Ikbkb_1
Description:Mus musculus inhibitor of kappaB kinase beta , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38822,706,559 - 22,706,619EPDNEW
RGD ID:6843312
Promoter ID:MM_KWN:53934
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:OTTMUST00000048779
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36823,803,831 - 23,804,331 (-)MPROMDB
RGD ID:6843338
Promoter ID:MM_KWN:53935
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4
Transcripts:NM_001159774,   OTTMUST00000048768,   OTTMUST00000048770,   OTTMUST00000048771,   OTTMUST00000048773,   OTTMUST00000048775,   OTTMUST00000048776,   UC009LDN.1,   UC009LDP.1,   UC009LDQ.1,   UC009LDS.1,   UC009LDV.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36823,816,774 - 23,817,274 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1338071 AgrOrtholog
Ensembl Genes ENSMUSG00000031537 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000033939 ENTREZGENE
  ENSMUST00000063401 ENTREZGENE
  ENSMUST00000125314 ENTREZGENE
  ENSMUST00000135326 ENTREZGENE
Gene3D-CATH 1.20.1270.250 UniProtKB/Swiss-Prot
  6.10.250.2110 UniProtKB/Swiss-Prot
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro IKBKB_SDD UniProtKB/Swiss-Prot
  IKBKB_SDD_sf UniProtKB/Swiss-Prot
  IKK UniProtKB/Swiss-Prot
  IKKbetaNEMObind UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report mmu:16150 UniProtKB/Swiss-Prot
MGD MGI:1338071 ENTREZGENE
NCBI Gene 16150 ENTREZGENE
PANTHER IKB KINASE UniProtKB/Swiss-Prot
  INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA UniProtKB/Swiss-Prot
Pfam IKBKB_SDD UniProtKB/Swiss-Prot
  IKKbetaNEMObind UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
PhenoGen Ikbkb PhenoGen
PROSITE PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
SMART IKKbetaNEMObind UniProtKB/Swiss-Prot
  S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A0R4J0T4 ENTREZGENE, UniProtKB/TrEMBL
  F6ULQ4_MOUSE UniProtKB/TrEMBL
  F6XPL0_MOUSE UniProtKB/TrEMBL
  IKKB_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q05DR8 ENTREZGENE, UniProtKB/TrEMBL
  Q3U141_MOUSE UniProtKB/TrEMBL
  Q3USX8_MOUSE UniProtKB/TrEMBL
  Q3V454_MOUSE UniProtKB/TrEMBL
  Q5D0E0 ENTREZGENE, UniProtKB/TrEMBL
  Q8BQA9_MOUSE UniProtKB/TrEMBL
  Q9R1J6 ENTREZGENE
UniProt Secondary Q9R1J6 UniProtKB/Swiss-Prot