Gsk3b (glycogen synthase kinase 3 beta) - Rat Genome Database

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Gene: Gsk3b (glycogen synthase kinase 3 beta) Mus musculus
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Symbol: Gsk3b
Name: glycogen synthase kinase 3 beta
RGD ID: 733892
MGI Page MGI
Description: Enables several functions, including beta-catenin binding activity; dynein complex binding activity; and tau-protein kinase activity. Involved in several processes, including apoptotic signaling pathway; positive regulation of organelle organization; and regulation of macromolecule biosynthetic process. Acts upstream of with a positive effect on autosome genomic imprinting. Acts upstream of or within several processes, including cellular response to hepatocyte growth factor stimulus; positive regulation of protein metabolic process; and regulation of neuron projection development. Located in several cellular components, including dendritic shaft; growth cone; and neuronal cell body. Part of Wnt signalosome; beta-catenin destruction complex; and ribonucleoprotein complex. Is active in glutamatergic synapse; meiotic spindle; and postsynaptic density. Is expressed in several structures, including alimentary system; genitourinary system; immune system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; oral squamous cell carcinoma; and schizophrenia. Orthologous to human GSK3B (glycogen synthase kinase 3 beta).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 7330414F15Rik; 8430431H08Rik; C86142; glycogen synthase kinase-3 beta; GSK; GSK-; GSK-3; GSK-3 beta; GSK-3be; GSK-3beta; GSK3; serine/threonine-protein kinase GSK3B
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391637,909,363 - 38,066,446 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1637,909,363 - 38,066,446 (+)EnsemblGRCm39 Ensembl
GRCm381638,089,001 - 38,246,084 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1638,089,001 - 38,246,084 (+)EnsemblGRCm38mm10GRCm38
MGSCv371638,089,087 - 38,246,165 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361638,008,240 - 38,165,318 (+)NCBIMGSCv36mm8
Celera1638,497,488 - 38,655,086 (+)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1626.54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Aberrant Crypt Foci  (ISO)
acute kidney failure  (ISO)
acute myocardial infarction  (ISO)
Alzheimer's disease  (IEP,IMP,ISO)
amyotrophic lateral sclerosis  (ISO)
bipolar disorder  (ISO)
Brain Injuries  (ISO)
Breast Neoplasms  (ISO)
Burns  (ISO)
Cardiomegaly  (ISO)
cognitive disorder  (ISO)
colon cancer  (ISO)
Colonic Neoplasms  (ISO)
colorectal adenocarcinoma  (ISO)
congestive heart failure  (ISO)
degenerative disc disease  (ISO)
depressive disorder  (ISO)
diabetic encephalopathy  (ISO)
Diabetic Nephropathies  (ISO)
dilated cardiomyopathy  (ISO)
Drug-Induced Dyskinesia  (ISO)
endometrial carcinoma  (ISO)
Endometrial Neoplasms  (ISO)
Experimental Arthritis  (ISO)
Experimental Mammary Neoplasms  (ISO)
Hearing Loss, Cisplatin-Induced  (IMP)
heart disease  (ISO)
hypertension  (ISO)
Intestinal Neoplasms  (IDA)
Liver Reperfusion Injury  (ISO)
mantle cell lymphoma  (ISO)
middle cerebral artery infarction  (ISO)
Multiple Abnormalities  (ISO)
muscular atrophy  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplastic Cell Transformation  (ISO)
neuronal ceroid lipofuscinosis 6A  (ISO)
oral squamous cell carcinoma  (ISO)
Ovarian Neoplasms  (ISO)
Parkinson's disease  (ISO)
peritonitis  (ISO)
Poisoning  (ISO)
Prostatic Neoplasms  (ISO)
schizophrenia  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
status epilepticus  (ISO)
Subarachnoid Hemorrhage  (ISO)
substance-related disorder  (ISO)
Tachycardia  (ISO)
tauopathy  (ISO)
type 2 diabetes mellitus  (IMP,ISO)
urinary bladder cancer  (ISO)
vascular dementia  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Tetrandrine  (ISO)
(-)-Arctigenin  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(-)-gambogic acid  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(R)-lipoic acid  (EXP,ISO)
(R)-salsolinol  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,8-cineole  (EXP)
1-(4-methoxybenzyl)-3-(5-nitro-1,3-thiazol-2-yl)urea  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
1-naphthyl isothiocyanate  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,5-hexanedione  (ISO)
2,6-dinitrotoluene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-chloroethanol  (EXP)
2-deoxy-D-glucose  (ISO)
2-methylcholine  (ISO)
2-nitrotoluene  (ISO)
20-hydroxyecdysone  (ISO)
26-hydroxycholesterol  (ISO)
3',5'-cyclic AMP  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,3'-diindolylmethane  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
3-methyladenine  (EXP,ISO)
3-nitropropanoic acid  (ISO)
3-phenylprop-2-enal  (EXP)
3alpha-hydroxy-5beta-pregnan-20-one  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-\{[4-(dimethylamino)phenyl]diazenyl\}phenyl-beta-lactoside  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP,ISO)
4-nitrophenol  (EXP)
4-vinylcyclohexene dioxide  (EXP)
5-(2-chloroethyl)-4-methylthiazole  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-methoxypsoralen  (EXP)
5alpha-pregnane-3,20-dione  (ISO)
6-aminonicotinamide  (ISO)
6-bromoindirubin-3'-oxime  (EXP,ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
[6]-Shogaol  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
adenosine  (ISO)
aflatoxin B1  (ISO)
AH23848  (ISO)
alachlor  (EXP)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-D-galactose  (EXP)
alsterpaullone  (ISO)
aluminium hydroxide  (ISO)
amino acid  (EXP)
amiodarone  (EXP,ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
amphetamine  (EXP,ISO)
andrographolide  (EXP,ISO)
antirheumatic drug  (ISO)
Antrocin  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
aspartame  (ISO)
Atipamezole  (ISO)
atrazine  (ISO)
avobenzone  (ISO)
Azoxymethane  (EXP)
baicalein  (ISO)
BAPTA  (ISO)
Bardoxolone methyl  (ISO)
belinostat  (ISO)
bellidifolin  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (EXP,ISO)
beta-D-glucosamine  (ISO)
betulin  (ISO)
betulinic acid  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
brazilein  (ISO)
bromochloroacetic acid  (ISO)
Bufotalin  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calycosin  (ISO)
calyculin A  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
captan  (EXP)
carbamazepine  (ISO)
carbon monoxide  (EXP)
carbon nanotube  (EXP)
carboxy-PTIO  (ISO)
celastrol  (EXP,ISO)
celecoxib  (ISO)
chaetoglobosin A  (ISO)
Chikusetsusaponin-V  (EXP)
CHIR 99021  (EXP,ISO)
chitosan  (ISO)
chloroethene  (EXP)
chlorogenic acid  (EXP)
chlorophyllin  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (ISO)
choline  (EXP)
chromium atom  (EXP)
chromium(6+)  (EXP)
chrysin 5,7-dimethyl ether  (ISO)
cilostazol  (EXP)
Cinobufagin  (ISO)
cisplatin  (EXP,ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
coenzyme Q10  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
columbamine  (EXP)
conjugated linoleic acid  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (EXP,ISO)
corynoline  (EXP)
coumarin  (ISO)
crocidolite asbestos  (ISO)
Cryptotanshinone  (ISO)
curcumin  (EXP,ISO)
cyanidin cation  (ISO)
cycloastragenol  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP,ISO)
DDE  (ISO)
DDT  (ISO)
deguelin  (ISO)
deoxynivalenol  (EXP)
desferrioxamine B  (ISO)
desmopressin  (EXP)
dexamethasone  (EXP,ISO)
dexmedetomidine  (ISO)
Di-n-hexyl phthalate  (ISO)
Di-n-octyl phthalate  (ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP,ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
Dictamnine  (ISO)
Didymin  (ISO)
dihydrolipoic acid  (ISO)
dioxygen  (EXP,ISO)
disodium cromoglycate  (ISO)
disodium selenite  (ISO)
dizocilpine maleate  (ISO)
dobutamine  (EXP)
donepezil hydrochloride  (EXP,ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
enalapril  (ISO)
endosulfan  (EXP,ISO)
entinostat  (ISO)
enzacamene  (ISO)
erastin  (ISO)
erlotinib hydrochloride  (ISO)
estragole  (ISO)
ethanol  (EXP,ISO)
ethosuximide  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (EXP)
eugenol  (ISO)
Evodiamine  (ISO)
excitatory amino acid agonist  (EXP,ISO)
famotidine  (ISO)
fipronil  (ISO)
fisetin  (ISO)
fluoxetine  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
fructose  (ISO)
fulvestrant  (EXP,ISO)
Fusaric acid  (EXP)
galactose  (EXP)
Gastrodin  (EXP,ISO)
gefitinib  (ISO)
gemcitabine  (ISO)
Gentiopicrin  (EXP)
geraniol  (ISO)
gingerol  (EXP,ISO)
ginsenoside Re  (EXP)
ginsenoside Rg1  (ISO)
ginsenoside Rg2  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
Glutathione ethyl ester  (ISO)
glycidol  (ISO)
glycidyl methacrylate  (ISO)
GSK2193874  (EXP)
GSK690693  (EXP,ISO)
haloperidol  (ISO)
hesperetin  (ISO)
hexachlorobenzene  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
IC-87114  (EXP)
icariside II  (ISO)
Icaritin  (EXP)
indirubin-3'-monoxime  (ISO)
indometacin  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isoorientin  (ISO)
isoprenaline  (EXP,ISO)
isorhapontigenin  (ISO)
ivermectin  (ISO)
kaempferol  (ISO)
kahweol  (ISO)
kainic acid  (EXP)
kenpaullone  (ISO)
ketamine  (ISO)
KT 5823  (ISO)
L-ascorbic acid  (ISO)
L-glutamic acid  (ISO)
L-methionine  (EXP)
L-serine  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (EXP)
lead(0)  (EXP,ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
liraglutide  (ISO)
lithium atom  (EXP,ISO)
lithium chloride  (EXP,ISO)
lithium hydride  (EXP,ISO)
lithocholic acid  (EXP)
Lobetyolin  (ISO)
loliolide  (ISO)
lonafarnib  (ISO)
losartan  (ISO)
lovastatin  (ISO)
lupeol  (ISO)
LY294002  (EXP,ISO)
lysophosphatidylethanolamine  (ISO)
magnesium atom  (ISO)
Magnolol  (ISO)
malathion  (ISO)
malvidin  (EXP)
mancozeb  (EXP)
maneb  (EXP)
manganese(II) chloride  (ISO)
melatonin  (EXP,ISO)
memantine  (ISO)
menadione  (ISO)
mercury dichloride  (EXP)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylglyoxal  (ISO)
methylmercury chloride  (EXP,ISO)
methylseleninic acid  (ISO)
microcystin-LR  (EXP,ISO)
mifepristone  (ISO)
mitomycin C  (ISO)
Mizoribine  (ISO)
MK-2206  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monocrotaline  (ISO)
monodansylcadaverine  (ISO)
morin  (ISO)
morphine  (EXP)
mycophenolic acid  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-D-aspartic acid  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-phosphocreatine  (ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naloxone  (EXP)
nectandrin B  (EXP,ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nimesulide  (ISO)
nitrofurazone  (ISO)
nitroprusside  (EXP,ISO)
nordihydroguaiaretic acid  (ISO)
notoginsenoside R1  (EXP,ISO)
ochratoxin A  (ISO)
okadaic acid  (EXP,ISO)
olanzapine  (ISO)
oleic acid  (ISO)
oleuropein  (EXP)
omethoate  (ISO)
oxaliplatin  (ISO)
oxybenzone  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
palmatine  (EXP)
Panaxadiol  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parecoxib  (ISO)
pentetrazol  (ISO)
perfluorododecanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP)
phenylephrine  (ISO)
phloretin  (ISO)
phloroglucinol  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phytoestrogen  (ISO)
pioglitazone  (ISO)
pirfenidone  (EXP)
Plantamajoside  (EXP,ISO)
PNU-282987  (ISO)
potassium atom  (ISO)
potassium chromate  (ISO)
proanthocyanidin  (ISO)
procyanidin B1  (ISO)
procyanidin B2  (ISO)
progesterone  (EXP,ISO)
propofol  (ISO)
propranolol  (ISO)
prostaglandin E2  (EXP,ISO)
pterostilbene  (EXP)
puerarin  (EXP,ISO)
pyrithione  (ISO)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (EXP,ISO)
quinacrine  (ISO)
radon atom  (ISO)
radon(0)  (ISO)
raffinose  (EXP,ISO)
Rebamipide  (ISO)
resveratrol  (EXP,ISO)
riboflavin  (EXP)
risperidone  (ISO)
Ro 31-8220  (ISO)
rotenone  (EXP,ISO)
rottlerin  (ISO)
royal jelly  (ISO)
rubimaillin  (ISO)
ruthenium atom  (ISO)
Salinomycin  (ISO)
Salvianolic acid A  (EXP)
SB 203580  (ISO)
SB 415286  (EXP,ISO)
SB 431542  (ISO)
SB-239063  (ISO)
sclareol  (ISO)
selenium atom  (ISO)
serotonin  (ISO)
serpentine asbestos  (ISO)
sesquiterpene  (ISO)
sevoflurane  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (EXP,ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
sodium fluoride  (ISO)
sorafenib  (ISO)
sphingosine 1-phosphate  (ISO)
streptozocin  (EXP,ISO)
succimer  (EXP)
sulfasalazine  (ISO)
sulforaphane  (EXP,ISO)
sulindac  (ISO)
syringic acid  (EXP)
T-2 toxin  (EXP,ISO)
tacrolimus hydrate  (ISO)
tadalafil  (EXP)
tamibarotene  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
Tanshinone I  (EXP)
taurine  (EXP,ISO)
taurochenodeoxycholic acid  (EXP)
temozolomide  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP)
tetrahydropalmatine  (EXP)
theophylline  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
thymoquinone  (ISO)
tideglusib  (ISO)
titanium dioxide  (EXP)
tolonium chloride  (EXP)
toluene 2,4-diisocyanate  (EXP)
topiramate  (ISO)
topotecan  (ISO)
Torularhodin  (ISO)
trametinib  (EXP)
trichloroethene  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
tungsten  (EXP)
urethane  (ISO)
Ursonic acid  (EXP)
valproic acid  (EXP,ISO)
valsartan  (EXP,ISO)
vanillic acid  (ISO)
vinclozolin  (ISO)
vitamin E  (EXP,ISO)
vitamin K  (ISO)
warfarin  (ISO)
wogonin  (ISO)
wortmannin  (EXP,ISO)
xanthosine  (ISO)
XAV939  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (IMP)
autosome genomic imprinting  (IEA,IMP)
axon extension  (IGI)
axonogenesis  (IGI)
bone remodeling  (ISO)
canonical Wnt signaling pathway  (IDA,IGI,ISO,ISS)
cell differentiation  (IBA,IEA)
cell growth involved in cardiac muscle cell development  (ISO)
cell migration  (IGI)
cellular response to amyloid-beta  (ISO)
cellular response to dopamine  (ISO)
cellular response to erythropoietin  (ISO)
cellular response to glucocorticoid stimulus  (IEA,IGI)
cellular response to hepatocyte growth factor stimulus  (IDA)
cellular response to hydrogen peroxide  (ISO)
cellular response to interleukin-3  (IDA,IEA)
cellular response to iron(II) ion  (ISO)
cellular response to lithium ion  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to retinoic acid  (ISO)
circadian rhythm  (IMP)
conditioned place preference  (ISO)
cytoplasmic translational initiation  (ISO)
cytoskeleton organization  (TAS)
epithelial to mesenchymal transition  (ISO,ISS)
ER overload response  (IDA,ISO)
establishment of cell polarity  (ISO)
establishment or maintenance of cell polarity  (ISO)
extrinsic apoptotic signaling pathway  (IGI)
extrinsic apoptotic signaling pathway in absence of ligand  (IDA,IEA)
fat cell differentiation  (IDA)
G1/S transition of mitotic cell cycle  (ISO)
glycogen metabolic process  (IEA,ISO)
hepatic stellate cell activation  (ISO)
hepatocyte apoptotic process  (ISO)
hippocampus development  (ISO)
insulin receptor signaling pathway  (IBA,IDA)
intracellular signal transduction  (ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (IDA)
lipopolysaccharide-mediated signaling pathway  (IMP)
maintenance of cell polarity  (ISO)
meiosis I  (IMP)
mitochondrion organization  (ISO)
myoblast fusion  (IDA,IGI)
myotube differentiation  (IGI)
negative regulation of apoptotic process  (IMP,ISO)
negative regulation of calcineurin-NFAT signaling cascade  (ISO,ISS)
negative regulation of canonical Wnt signaling pathway  (IBA,IMP,ISO)
negative regulation of cardiac muscle hypertrophy  (IDA,IEA)
negative regulation of cell migration  (ISO)
negative regulation of dendrite development  (ISO)
negative regulation of dendrite morphogenesis  (ISO)
negative regulation of developmental process  (IEA)
negative regulation of dopaminergic neuron differentiation  (ISO)
negative regulation of epithelial to mesenchymal transition  (ISO,ISS)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (ISO,ISS)
negative regulation of gene expression  (ISO)
negative regulation of glycogen biosynthetic process  (IMP)
negative regulation of insulin receptor signaling pathway  (ISO)
negative regulation of MAP kinase activity  (ISO)
negative regulation of mesenchymal stem cell differentiation  (ISO)
negative regulation of neuron maturation  (IGI)
negative regulation of neuron migration  (ISO)
negative regulation of neuron projection development  (IGI,IMP)
negative regulation of nitric-oxide synthase activity  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of proteasomal ubiquitin-dependent protein catabolic process  (ISO)
negative regulation of protein localization to centrosome  (IMP)
negative regulation of protein localization to nucleus  (ISO)
negative regulation of protein-containing complex assembly  (ISO)
negative regulation of signal transduction  (IEA)
negative regulation of smooth muscle cell apoptotic process  (ISO)
negative regulation of synaptic assembly at neuromuscular junction  (ISO)
negative regulation of TOR signaling  (IBA,IEA,IGI)
negative regulation of TORC2 signaling  (ISO,ISS)
negative regulation of ubiquitin-dependent protein catabolic process  (ISO)
nervous system development  (IEA)
neuron projection development  (ISO,ISS)
neuron projection organization  (ISO)
peptidyl-serine phosphorylation  (IDA,ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IMP,ISO)
phosphorylation  (IMP)
positive regulation of apoptotic process  (ISO)
positive regulation of autophagy  (IBA,IDA,IEA,IGI)
positive regulation of axon extension  (IGI)
positive regulation of cardiac muscle cell differentiation  (IMP)
positive regulation of cell differentiation  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell-matrix adhesion  (ISO)
positive regulation of cilium assembly  (IMP)
positive regulation of DNA biosynthetic process  (ISO)
positive regulation of excitatory postsynaptic potential  (ISO)
positive regulation of gene expression  (IGI,IMP,ISO)
positive regulation of mitochondrial membrane potential  (ISO)
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  (IDA,IEA)
positive regulation of neuron apoptotic process  (IBA,ISO)
positive regulation of osteoblast proliferation  (ISO)
positive regulation of osteoclast differentiation  (ISO)
positive regulation of osteoclast proliferation  (ISO)
positive regulation of peptidyl-threonine phosphorylation  (IDA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IBA,IGI,ISO)
positive regulation of protein catabolic process  (ISO)
positive regulation of protein export from nucleus  (ISO)
positive regulation of protein localization to centrosome  (ISO)
positive regulation of protein localization to cilium  (IMP)
positive regulation of protein ubiquitination  (ISO)
positive regulation of protein-containing complex assembly  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of stem cell differentiation  (IMP)
positive regulation of substrate adhesion-dependent cell spreading  (IMP)
positive regulation of synaptic assembly at neuromuscular junction  (ISO)
positive regulation of transcription by RNA polymerase II  (IMP,ISO)
positive regulation of translation  (ISO)
presynaptic modulation of chemical synaptic transmission  (ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (ISO,NAS)
protein autophosphorylation  (ISO)
protein export from nucleus  (IDA)
protein localization to microtubule  (IGI)
protein phosphorylation  (IDA,IGI,IMP,ISO)
re-entry into mitotic cell cycle  (IDA)
regulation of apoptotic process  (IMP)
regulation of axon extension  (ISO)
regulation of axonogenesis  (ISO)
regulation of cell growth  (IEA,IMP)
regulation of circadian rhythm  (IMP)
regulation of dendrite morphogenesis  (ISO)
regulation of long-term synaptic potentiation  (IMP)
regulation of microtubule anchoring at centrosome  (ISO)
regulation of microtubule cytoskeleton organization  (IBA,ISO)
regulation of microtubule-based process  (IDA,ISO)
regulation of mitotic cell cycle  (ISO)
regulation of modification of postsynaptic structure  (ISO)
regulation of neuron projection development  (IBA,IGI)
regulation of neuronal synaptic plasticity  (ISO)
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane  (ISO)
regulation of osteoblast differentiation  (ISO)
regulation of protein export from nucleus  (ISO,ISS)
regulation of striated muscle cell differentiation  (IEA)
response to activity  (ISO)
response to angiotensin  (ISO)
response to endoplasmic reticulum stress  (ISO)
response to epinephrine  (ISO)
response to estradiol  (ISO)
response to insulin  (ISO)
response to insulin-like growth factor stimulus  (ISO)
response to L-glutamate  (ISO)
response to methamphetamine hydrochloride  (ISO)
response to ultrasound  (ISO)
response to xenobiotic stimulus  (ISO)
response to zinc ion  (ISO)
rhythmic process  (IEA)
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  (ISO)
stem cell differentiation  (IMP)
superior temporal gyrus development  (ISO)
TORC2 signaling  (ISO)
transcription by RNA polymerase II  (IMP)
Wnt signaling pathway  (IEA,IGI,ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal behavioral response to xenobiotic  (IAGP)
abnormal bone healing  (IAGP)
abnormal circulating glucose level  (IAGP)
abnormal circulating insulin level  (IAGP)
abnormal clavicle morphology  (IAGP)
abnormal contextual conditioning behavior  (IAGP)
abnormal fontanelle morphology  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal glycogen homeostasis  (IAGP)
abnormal heart electrocardiography waveform feature  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal learning/memory/conditioning  (IAGP)
abnormal liver morphology  (IAGP)
abnormal long-term depression  (IAGP)
abnormal osteoblast physiology  (IAGP)
abnormal palate development  (IAGP)
abnormal pancreatic islet cell apoptosis  (IAGP)
abnormal proximal convoluted tubule morphology  (IAGP)
abnormal renal tubule morphology  (IAGP)
abnormal S wave  (IAGP)
abnormal skeleton development  (IAGP)
abnormal skeleton physiology  (IAGP)
abnormal social investigation  (IAGP)
abnormal spatial reference memory  (IAGP)
abnormal sternum ossification  (IAGP)
abnormal urinary bladder urothelium morphology  (IAGP)
abnormal Wallerian degeneration  (IAGP)
behavioral despair  (IAGP)
cardiac fibrosis  (IAGP)
cleft palate  (IAGP)
cleft secondary palate  (IAGP)
complete cleft palate  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased coping response  (IAGP)
decreased exploration in new environment  (IAGP)
decreased myocardial infarct size  (IAGP)
decreased P wave amplitude  (IAGP)
decreased pancreatic beta cell mass  (IAGP)
decreased prepulse inhibition  (IAGP)
delayed bone ossification  (IAGP)
enhanced contextual conditioning behavior  (IAGP)
enhanced osteoblast differentiation  (IAGP)
failure of palatal shelf elevation  (IAGP)
hyperactivity  (IAGP)
impaired cued conditioning behavior  (IAGP)
improved glucose tolerance  (IAGP)
increased anxiety-related response  (IAGP)
increased bone mass  (IAGP)
increased bone ossification  (IAGP)
increased bone resorption  (IAGP)
increased circulating corticosterone level  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating interleukin-6 level  (IAGP)
increased compact bone mass  (IAGP)
increased compact bone thickness  (IAGP)
increased compact bone volume  (IAGP)
increased exploration in new environment  (IAGP)
increased glycogen level  (IAGP)
increased liver glycogen level  (IAGP)
increased myocardial infarct size  (IAGP)
increased pancreatic beta cell proliferation  (IAGP)
increased Q wave amplitude  (IAGP)
increased thigmotaxis  (IAGP)
increased trabecular bone mass  (IAGP)
increased trabecular bone volume  (IAGP)
insulin resistance  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IEA)
palatal shelves fail to meet at midline  (IAGP)
preweaning lethality, complete penetrance  (IEA)
prolonged PR interval  (IAGP)
prolonged QRS complex duration  (IAGP)
split sternum  (IAGP)
xiphoid process foramen  (IAGP)
References

References - curated
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46. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
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Additional References at PubMed
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PMID:12420304   PMID:12432063   PMID:12447879   PMID:12477932   PMID:12489109   PMID:12520002   PMID:12584189   PMID:12668682   PMID:12714590   PMID:12796505   PMID:12805290   PMID:12808104  
PMID:12871932   PMID:12874278   PMID:12904583   PMID:12937146   PMID:14502571   PMID:14522949   PMID:14536078   PMID:14563837   PMID:14602710   PMID:14610273   PMID:14651959   PMID:14660435  
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PMID:15073180   PMID:15140013   PMID:15192701   PMID:15207235   PMID:15252041   PMID:15282284   PMID:15282335   PMID:15308623   PMID:15327768   PMID:15345747   PMID:15456937   PMID:15466414  
PMID:15489334   PMID:15527765   PMID:15548427   PMID:15572268   PMID:15582777   PMID:15592455   PMID:15674326   PMID:15695173   PMID:15713628   PMID:15731007   PMID:15782199   PMID:15791206  
PMID:15867159   PMID:15972822   PMID:15980066   PMID:15993040   PMID:15994955   PMID:16007092   PMID:16049178   PMID:16051150   PMID:16054035   PMID:16055726   PMID:16109394   PMID:16141072  
PMID:16141073   PMID:16162663   PMID:16166627   PMID:16176184   PMID:16179343   PMID:16192643   PMID:16230462   PMID:16257959   PMID:16258844   PMID:16303557   PMID:16341242   PMID:16428445  
PMID:16452087   PMID:16462886   PMID:16464655   PMID:16510873   PMID:16522636   PMID:16537926   PMID:16543145   PMID:16543730   PMID:16551619   PMID:16600022   PMID:16601113   PMID:16602821  
PMID:16682216   PMID:16687499   PMID:16713974   PMID:16723502   PMID:16772333   PMID:16803897   PMID:16815997   PMID:16816383   PMID:16941690   PMID:16942622   PMID:16943560   PMID:16954147  
PMID:16959610   PMID:16962829   PMID:16987252   PMID:16987962   PMID:17021036   PMID:17026964   PMID:17032918   PMID:17043650   PMID:17052453   PMID:17053159   PMID:17108173   PMID:17114649  
PMID:17166938   PMID:17178402   PMID:17182001   PMID:17185343   PMID:17293880   PMID:17314294   PMID:17322895   PMID:17371841   PMID:17387146   PMID:17391670   PMID:17490435   PMID:17543867  
PMID:17548347   PMID:17560576   PMID:17569662   PMID:17607667   PMID:17608927   PMID:17666435   PMID:17698586   PMID:17709384   PMID:17711861   PMID:17726008   PMID:17786208   PMID:17895382  
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PMID:18295757   PMID:18316368   PMID:18318434   PMID:18322105   PMID:18323411   PMID:18327788   PMID:18346206   PMID:18351675   PMID:18353303   PMID:18367454   PMID:18367611   PMID:18367674  
PMID:18369660   PMID:18398001   PMID:18451303   PMID:18466329   PMID:18469539   PMID:18490522   PMID:18492954   PMID:18502760   PMID:18550525   PMID:18551195   PMID:18563716   PMID:18583716  
PMID:18602000   PMID:18619545   PMID:18632640   PMID:18632848   PMID:18655171   PMID:18669927   PMID:18690793   PMID:18694957   PMID:18701453   PMID:18716223   PMID:18721193   PMID:18723505  
PMID:18723514   PMID:18760348   PMID:18778410   PMID:18786638   PMID:18787067   PMID:18799693   PMID:18801732   PMID:18806775   PMID:18824542   PMID:18830417   PMID:18838540   PMID:18851840  
PMID:18929413   PMID:18946023   PMID:18946175   PMID:18952601   PMID:18958152   PMID:18978355   PMID:18981097   PMID:18987114   PMID:19011050   PMID:19047045   PMID:19064989   PMID:19106302  
PMID:19107203   PMID:19118544   PMID:19141611   PMID:19193882   PMID:19214430   PMID:19218245   PMID:19223464   PMID:19233194   PMID:19233709   PMID:19237556   PMID:19243017   PMID:19258035  
PMID:19303846   PMID:19324938   PMID:19328817   PMID:19349584   PMID:19357198   PMID:19369384   PMID:19379814   PMID:19382207   PMID:19389373   PMID:19398579   PMID:19408126   PMID:19412553  
PMID:19430525   PMID:19448134   PMID:19454488   PMID:19481076   PMID:19507191   PMID:19515997   PMID:19520363   PMID:19542364   PMID:19542610   PMID:19555761   PMID:19576224   PMID:19607922  
PMID:19620286   PMID:19622347   PMID:19642201   PMID:19675674   PMID:19706605   PMID:19799873   PMID:19801986   PMID:19829382   PMID:19833727   PMID:19840222   PMID:19840939   PMID:19841191  
PMID:19850877   PMID:19858210   PMID:19903789   PMID:19959876   PMID:20004245   PMID:20007913   PMID:20010698   PMID:20040596   PMID:20049328   PMID:20056751   PMID:20061376   PMID:20083607  
PMID:20093356   PMID:20111716   PMID:20123978   PMID:20127719   PMID:20146080   PMID:20150512   PMID:20194497   PMID:20211702   PMID:20231377   PMID:20299330   PMID:20300527   PMID:20347018  
PMID:20347968   PMID:20351102   PMID:20357757   PMID:20360256   PMID:20371704   PMID:20404919   PMID:20497256   PMID:20528914   PMID:20530871   PMID:20534517   PMID:20541704   PMID:20552232  
PMID:20553816   PMID:20575007   PMID:20576499   PMID:20576936   PMID:20584904   PMID:20592205   PMID:20592207   PMID:20596079   PMID:20600866   PMID:20604929   PMID:20623542   PMID:20625330  
PMID:20626347   PMID:20665729   PMID:20680007   PMID:20687111   PMID:20696171   PMID:20696185   PMID:20720513   PMID:20729209   PMID:20729907   PMID:20818428   PMID:20823064   PMID:20848477  
PMID:20858757   PMID:20890042   PMID:20926391   PMID:20969844   PMID:20980993   PMID:20981831   PMID:21035757   PMID:21047779   PMID:21061060   PMID:21062867   PMID:21063101   PMID:21072211  
PMID:21076497   PMID:21084607   PMID:21130869   PMID:21148798   PMID:21160051   PMID:21173228   PMID:21191064   PMID:21194439   PMID:21233250   PMID:21242974   PMID:21245377   PMID:21246654  
PMID:21248711   PMID:21253590   PMID:21253820   PMID:21267068   PMID:21295277   PMID:21295697   PMID:21317289   PMID:21319221   PMID:21325041   PMID:21376063   PMID:21392539   PMID:21421818  
PMID:21435461   PMID:21460223   PMID:21471969   PMID:21482799   PMID:21493770   PMID:21502951   PMID:21515258   PMID:21531375   PMID:21541314   PMID:21557011   PMID:21558417   PMID:21602809  
PMID:21624348   PMID:21628472   PMID:21631154   PMID:21658600   PMID:21660969   PMID:21677750   PMID:21685889   PMID:21690373   PMID:21697359   PMID:21697459   PMID:21700708   PMID:21709141  
PMID:21709260   PMID:21731673   PMID:21731714   PMID:21737790   PMID:21738215   PMID:21782525   PMID:21803945   PMID:21821916   PMID:21832246   PMID:21856776   PMID:21873526   PMID:21873635  
PMID:21898827   PMID:21911068   PMID:21914493   PMID:21922189   PMID:21937454   PMID:21949120   PMID:21956113   PMID:21960132   PMID:22019984   PMID:22022450   PMID:22022457   PMID:22037925  
PMID:22057101   PMID:22064483   PMID:22065737   PMID:22073301   PMID:22096483   PMID:22114306   PMID:22131333   PMID:22140263   PMID:22152249   PMID:22158133   PMID:22179679   PMID:22219288  
PMID:22249311   PMID:22275805   PMID:22355693   PMID:22384031   PMID:22393041   PMID:22420773   PMID:22484461   PMID:22508726   PMID:22539723   PMID:22625652   PMID:22640738   PMID:22660580  
PMID:22661511   PMID:22665058   PMID:22672822   PMID:22674256   PMID:22682247   PMID:22687243   PMID:22693173   PMID:22698482   PMID:22732552   PMID:22751928   PMID:22761446   PMID:22763697  
PMID:22768254   PMID:22773863   PMID:22785175   PMID:22791713   PMID:22800848   PMID:22814108   PMID:22814751   PMID:22814966   PMID:22825252   PMID:22826345   PMID:22832527   PMID:22849606  
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PMID:23570858   PMID:23606540   PMID:23618343   PMID:23628704   PMID:23632329   PMID:23648819   PMID:23658842   PMID:23707483   PMID:23737518   PMID:23769106   PMID:23778311   PMID:23784744  
PMID:23796137   PMID:23798682   PMID:23807397   PMID:23817039   PMID:23823480   PMID:23853095   PMID:23860320   PMID:23880761   PMID:23884889   PMID:23900020   PMID:23904355   PMID:23919927  
PMID:23951407   PMID:23972596   PMID:23973862   PMID:24003036   PMID:24018603   PMID:24020380   PMID:24055036   PMID:24094580   PMID:24099767   PMID:24124534   PMID:24138923   PMID:24141459  
PMID:24142875   PMID:24162165   PMID:24204656   PMID:24209762   PMID:24227739   PMID:24260404   PMID:24275123   PMID:24298146   PMID:24302887   PMID:24319055   PMID:24333443   PMID:24333578  
PMID:24335145   PMID:24356466   PMID:24371086   PMID:24397546   PMID:24412473   PMID:24425879   PMID:24457600   PMID:24458356   PMID:24462873   PMID:24468825   PMID:24523925   PMID:24531650  
PMID:24623780   PMID:24634145   PMID:24634488   PMID:24685987   PMID:24691449   PMID:24692544   PMID:24705253   PMID:24713193   PMID:24733831   PMID:24777252   PMID:24811175   PMID:24899689  
PMID:24912492   PMID:24915968   PMID:24923837   PMID:24952961   PMID:24974728   PMID:25003317   PMID:25038456   PMID:25046438   PMID:25064057   PMID:25073924   PMID:25078444   PMID:25088904  
PMID:25127359   PMID:25150591   PMID:25183803   PMID:25192600   PMID:25195860   PMID:25196127   PMID:25208523   PMID:25219467   PMID:25224226   PMID:25231981   PMID:25234596   PMID:25239564  
PMID:25239914   PMID:25273085   PMID:25313506   PMID:25316136   PMID:25331900   PMID:25339176   PMID:25355398   PMID:25390651   PMID:25394490   PMID:25398937   PMID:25468908   PMID:25472995  
PMID:25477508   PMID:25484286   PMID:25496993   PMID:25525303   PMID:25565601   PMID:25573755   PMID:25629551   PMID:25629553   PMID:25630719   PMID:25691750   PMID:25701174   PMID:25724980  
PMID:25728276   PMID:25767272   PMID:25779040   PMID:25781227   PMID:25788881   PMID:25808536   PMID:25814664   PMID:25821218   PMID:25828701   PMID:25833158   PMID:25833708   PMID:25860027  
PMID:25926459   PMID:25937288   PMID:25963821   PMID:25975226   PMID:25977369   PMID:26026611   PMID:26063791   PMID:26100021   PMID:26109067   PMID:26116229   PMID:26151480   PMID:26156074  
PMID:26159930   PMID:26160071   PMID:26179612   PMID:26206086   PMID:26220974   PMID:26240067   PMID:26240334   PMID:26243309   PMID:26313916   PMID:26370326   PMID:26487282   PMID:26493106  
PMID:26496610   PMID:26499802   PMID:26526197   PMID:26546129   PMID:26567873   PMID:26582204   PMID:26633882   PMID:26638989   PMID:26647425   PMID:26667039   PMID:26719331   PMID:26749572  
PMID:26766591   PMID:26809587   PMID:26822034   PMID:26876299   PMID:26885856   PMID:26886780   PMID:26887949   PMID:26926143   PMID:26974342   PMID:26976650   PMID:26993057   PMID:26996481  
PMID:27003207   PMID:27010852   PMID:27026523   PMID:27053198   PMID:27092510   PMID:27106044   PMID:27113764   PMID:27124580   PMID:27140617   PMID:27152166   PMID:27161213   PMID:27170189  
PMID:27170944   PMID:27190311   PMID:27215380   PMID:27232654   PMID:27284979   PMID:27313176   PMID:27378458   PMID:27466200   PMID:27478647   PMID:27501329   PMID:27507650   PMID:27526674  
PMID:27537208   PMID:27575935   PMID:27614023   PMID:27628899   PMID:27632389   PMID:27649495   PMID:27663455   PMID:27678414   PMID:27681429   PMID:27687730   PMID:27693558   PMID:27738106  
PMID:27789627   PMID:27807348   PMID:27832289   PMID:27841351   PMID:28053206   PMID:28057765   PMID:28063983   PMID:28077597   PMID:28098160   PMID:28114292   PMID:28137967   PMID:28153048  
PMID:28161398   PMID:28164238   PMID:28196122   PMID:28240305   PMID:28244152   PMID:28266127   PMID:28298444   PMID:28352664   PMID:28421199   PMID:28453729   PMID:28556462   PMID:28562582  
PMID:28609678   PMID:28617442   PMID:28617951   PMID:28630333   PMID:28637674   PMID:28639695   PMID:28650469   PMID:28671696   PMID:28706196   PMID:28720858   PMID:28754897   PMID:28790387  
PMID:28808228   PMID:28819213   PMID:28892081   PMID:28903391   PMID:28916722   PMID:28943449   PMID:28952285   PMID:28952290   PMID:29036833   PMID:29049420   PMID:29073967   PMID:29082245  
PMID:29109121   PMID:29111324   PMID:29129695   PMID:29142209   PMID:29143288   PMID:29228573   PMID:29353218   PMID:29382851   PMID:29420689   PMID:29437042   PMID:29452207   PMID:29461205  
PMID:29555900   PMID:29574946   PMID:29579399   PMID:29587154   PMID:29593329   PMID:29642012   PMID:29669786   PMID:29742424   PMID:29761559   PMID:29768193   PMID:29775963   PMID:29790931  
PMID:29883716   PMID:29997171   PMID:30061109   PMID:30068389   PMID:30069702   PMID:30119888   PMID:30125581   PMID:30197003   PMID:30217816   PMID:30326250   PMID:30447378   PMID:30457570  
PMID:30499878   PMID:30502054   PMID:30511419   PMID:30535296   PMID:30579834   PMID:30678114   PMID:30679422   PMID:30688489   PMID:30704899   PMID:30711399   PMID:30745182   PMID:30790505  
PMID:30854564   PMID:30866939   PMID:30890376   PMID:30898653   PMID:30978208   PMID:30981804   PMID:31073040   PMID:31075901   PMID:31138536   PMID:31185200   PMID:31220102   PMID:31284950  
PMID:31420527   PMID:31442251   PMID:31453382   PMID:31462248   PMID:31509448   PMID:31515471   PMID:31540917   PMID:31553910   PMID:31577955   PMID:31581792   PMID:31619538   PMID:31679397  
PMID:31722791   PMID:31760890   PMID:31783102   PMID:31791666   PMID:31831767   PMID:31881263   PMID:31892408   PMID:31900153   PMID:32000863   PMID:32034125   PMID:32087280   PMID:32113851  
PMID:32141492   PMID:32149120   PMID:32163656   PMID:32165725   PMID:32209671   PMID:32325033   PMID:32365965   PMID:32366272   PMID:32439763   PMID:32554707   PMID:32560668   PMID:32575075  
PMID:32578216   PMID:32581704   PMID:32581705   PMID:32584144   PMID:32680958   PMID:32706136   PMID:32711020   PMID:32713252   PMID:32719388   PMID:32729236   PMID:32798765   PMID:32812777  
PMID:32813289   PMID:32817370   PMID:32828530   PMID:32937135   PMID:32961796   PMID:33029741   PMID:33067366   PMID:33107080   PMID:33190828   PMID:33259794   PMID:33431651   PMID:33436499  
PMID:33547321   PMID:33777320   PMID:33823913   PMID:33848269   PMID:34301885   PMID:34321999   PMID:34394077   PMID:34400288   PMID:34431536   PMID:34489431   PMID:34518365   PMID:34547456  
PMID:34599818   PMID:34623920   PMID:34638997   PMID:34710087   PMID:34812500   PMID:34948382   PMID:34997541   PMID:35159367   PMID:35166234   PMID:35168370   PMID:35259458   PMID:35260764  
PMID:35401100   PMID:35440636   PMID:35476671   PMID:35563060   PMID:35589394   PMID:35614465   PMID:35634666   PMID:35718239   PMID:35747513   PMID:35902588   PMID:36057401   PMID:36070513  
PMID:36103829   PMID:36209826   PMID:36223831   PMID:36337049   PMID:36422999   PMID:36447045   PMID:36613781   PMID:36854759   PMID:36883011   PMID:37037996   PMID:37142655   PMID:37156294  
PMID:37255478   PMID:37258579   PMID:37330908   PMID:37349645   PMID:37392853   PMID:37511396   PMID:37553426   PMID:37553428   PMID:37632751   PMID:37700593   PMID:37737269   PMID:37762417  
PMID:37771085   PMID:37778692   PMID:37922427   PMID:37944068   PMID:37982452   PMID:38193163   PMID:38351062   PMID:38479223   PMID:38536552   PMID:38546584   PMID:38653356   PMID:38719751  
PMID:38762650   PMID:39217874   PMID:39510449   PMID:40013943   PMID:40052215  


Genomics

Comparative Map Data
Gsk3b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391637,909,363 - 38,066,446 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1637,909,363 - 38,066,446 (+)EnsemblGRCm39 Ensembl
GRCm381638,089,001 - 38,246,084 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1638,089,001 - 38,246,084 (+)EnsemblGRCm38mm10GRCm38
MGSCv371638,089,087 - 38,246,165 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361638,008,240 - 38,165,318 (+)NCBIMGSCv36mm8
Celera1638,497,488 - 38,655,086 (+)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1626.54NCBI
GSK3B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383119,821,321 - 120,094,447 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3119,821,321 - 120,094,994 (-)EnsemblGRCh38hg38GRCh38
GRCh373119,540,168 - 119,813,294 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363121,028,233 - 121,295,203 (-)NCBINCBI36Build 36hg18NCBI36
Build 343121,028,237 - 121,295,203NCBI
Celera3117,949,905 - 118,223,017 (-)NCBICelera
Cytogenetic Map3q13.33NCBI
HuRef3116,916,542 - 117,189,344 (-)NCBIHuRef
CHM1_13119,504,331 - 119,776,722 (-)NCBICHM1_1
T2T-CHM13v2.03122,541,048 - 122,814,129 (-)NCBIT2T-CHM13v2.0
Gsk3b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81176,004,502 - 76,154,665 (-)NCBIGRCr8
GRCr8 Ensembl1176,009,507 - 76,153,249 (-)EnsemblGRCr8 Ensembl
mRatBN7.21162,498,997 - 62,648,665 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1162,504,316 - 62,648,646 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1171,316,816 - 71,460,263 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01163,979,039 - 64,122,494 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01163,029,506 - 63,172,937 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01165,060,884 - 65,208,842 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,066,235 - 65,209,268 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01166,873,291 - 67,016,640 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41164,284,731 - 64,428,698 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1162,004,680 - 62,147,081 (-)NCBICelera
RGSC_v3.11164,342,319 - 64,486,287 (-)NCBI
RH 3.4 Map11501.41RGD
Cytogenetic Map11q21NCBI
Gsk3b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542719,495,422 - 19,671,137 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542719,489,972 - 19,671,137 (-)NCBIChiLan1.0ChiLan1.0
GSK3B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22117,803,084 - 118,069,881 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13117,803,362 - 118,073,878 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03116,943,205 - 117,215,001 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13123,856,047 - 124,126,747 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3123,861,379 - 124,126,771 (-)Ensemblpanpan1.1panPan2
GSK3B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13323,458,369 - 23,659,878 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3323,463,767 - 23,659,666 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3323,488,457 - 23,689,804 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03323,696,164 - 23,823,688 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3323,714,581 - 23,900,333 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13323,500,322 - 23,702,303 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03323,541,326 - 23,742,436 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03324,104,403 - 24,306,119 (-)NCBIUU_Cfam_GSD_1.0
Gsk3b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602130,628,163 - 130,791,946 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365366,730,062 - 6,894,303 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365366,730,070 - 6,893,818 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GSK3B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13140,136,158 - 140,369,569 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113140,136,109 - 140,370,197 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213149,431,156 - 149,510,315 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.213149,599,661 - 149,702,154 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GSK3B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12260,732,449 - 61,002,735 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2260,733,465 - 60,997,239 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041105,307,531 - 105,584,674 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gsk3b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473128,178,628 - 28,366,420 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473128,178,647 - 28,368,784 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gsk3b
4883 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:2163
Count of miRNA genes:844
Interacting mature miRNAs:1135
Transcripts:ENSMUST00000023507, ENSMUST00000114750, ENSMUST00000132057, ENSMUST00000134870
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11059560Lmr12b_mleishmaniasis resistance 12b (mouse)162879281362792952Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16841786490896888Mouse
1301841Lrnx9_mlearning-contextual 9 (mouse)Not determined161222536046225471Mouse
1302096Aod1a_mautoimmune ovarian dysgenesis 1a (mouse)Not determined163544664392573008Mouse
4141179Ipng3_mimprinted postnatal growth 3 (mouse)Not determined2277525257594076Mouse
38501069Tip4_mtuberculosis immunophenotype 4, IFN-g level (mouse)16431786444520363Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16381786464620363Mouse
11049571Lmr12c_mleishmaniasis resistance 12c (mouse)162879281362792952Mouse
1301086Lprm5_mlymphoproliferation modifier 5 (mouse)Not determined161184882445848923Mouse
27226768Tibl9_mtibia length 9, 5 week (mouse)16331786451420363Mouse
11059559Lmr12a_mleishmaniasis resistance 12a (mouse)162879281362792952Mouse
1301443Mopkd2_mmodifier of polycystic kidney disease progression 2 (mouse)Not determined16464631438646414Mouse
10043978Obq35_mobesity QTL 35 (mouse)Not determined16988163143881631Mouse
4142187Arrd3_mage-related retinal degeneration 3 (mouse)Not determined3252290965466552Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16654297965466552Mouse
1357517Bwtn1_mbody weight at necropsy 1 (mouse)Not determined162001932985600826Mouse
26884416Bzwq5_mbi-zygomatic width QTL 5, 5 week (mouse)163732036284696888Mouse
1300943Skts9_mskin tumor susceptibility 9 (mouse)Not determined16577525239775440Mouse
1301070Cypr1_mcytokine production 1 (mouse)Not determined163231279566312933Mouse
1300915Lmr12_mleishmaniasis resistance 12 (mouse)Not determined162879281362792952Mouse
1300656Bgeq15_mbody growth early QTL 15 (mouse)Not determined16577525239775440Mouse
4142236Pstc4_mperiosteal circumference 4 (mouse)Not determined161552290949523112Mouse
1300534Bmd15_mbone mineral density 15 (mouse)Not determined162193838355938574Mouse
11251724Ewc6_methanol withdrawal and consumption 6 (mouse)16822605242226052Mouse
1300987Skull23_mskull morphology 23 (mouse)Not determined16577525239775440Mouse
1301945Skl7_mskeletal size (tail length) 7 (mouse)Not determined16577525239775440Mouse
10045614Rapop6_mradiation-induced apoptosis 6 (mouse)Not determined161480292148803032Mouse
15092062Egrme4_mearly growth rate, maternal effect 4 (mouse)162521866444220250Mouse
27095908Scvln7_msacral vertebrae length 2, 5 week (mouse)16331786439820362Mouse
10412263Gvhd6_mgraft-versus host disease 6 (mouse)Not determined163606085745511148Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16331786464620363Mouse

Markers in Region
RH127269  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381638,243,757 - 38,243,988UniSTSGRCm38
MGSCv371638,243,843 - 38,244,074UniSTSGRCm37
Celera1638,652,766 - 38,652,997UniSTS
Cytogenetic Map16B4UniSTS
RH136442  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381638,243,676 - 38,243,875UniSTSGRCm38
MGSCv371638,243,762 - 38,243,961UniSTSGRCm37
Celera1638,652,685 - 38,652,884UniSTS
Cytogenetic Map16B4UniSTS
RH129577  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381638,144,261 - 38,144,449UniSTSGRCm38
MGSCv371638,144,347 - 38,144,535UniSTSGRCm37
Celera1638,552,858 - 38,553,046UniSTS
Cytogenetic Map16B4UniSTS
Gsk3b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16B4UniSTS
cM Map16 UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001347232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_019827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030249221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB066114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC120020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC154284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF156099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK005170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK020183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK021230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK078822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC006936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC032976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC060743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000023507   ⟹   ENSMUSP00000023507
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1637,909,363 - 38,066,446 (+)Ensembl
GRCm38.p6 Ensembl1638,089,001 - 38,246,084 (+)Ensembl
Ensembl Acc Id: ENSMUST00000114750   ⟹   ENSMUSP00000110398
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1637,910,650 - 38,061,141 (+)Ensembl
GRCm38.p6 Ensembl1638,090,288 - 38,240,779 (+)Ensembl
Ensembl Acc Id: ENSMUST00000132057
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1637,964,657 - 38,029,852 (+)Ensembl
GRCm38.p6 Ensembl1638,144,295 - 38,209,490 (+)Ensembl
Ensembl Acc Id: ENSMUST00000134870
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1637,963,693 - 38,011,993 (+)Ensembl
GRCm38.p6 Ensembl1638,143,331 - 38,191,631 (+)Ensembl
Ensembl Acc Id: ENSMUST00000231437   ⟹   ENSMUSP00000156065
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1638,028,400 - 38,061,466 (+)Ensembl
GRCm38.p6 Ensembl1638,208,038 - 38,241,104 (+)Ensembl
RefSeq Acc Id: NM_001347232   ⟹   NP_001334161
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391637,909,363 - 38,066,446 (+)NCBI
GRCm381638,089,001 - 38,246,084 (+)NCBI
Sequence:
RefSeq Acc Id: NM_019827   ⟹   NP_062801
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391637,909,363 - 38,066,446 (+)NCBI
GRCm381638,089,001 - 38,246,084 (+)NCBI
MGSCv371638,089,087 - 38,246,165 (+)RGD
Celera1638,497,488 - 38,655,086 (+)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030249221   ⟹   XP_030105081
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391637,963,640 - 38,066,442 (+)NCBI
GRCm381638,143,248 - 38,246,080 (+)NCBI
Sequence:
RefSeq Acc Id: NP_062801   ⟸   NM_019827
- Peptide Label: isoform 1
- UniProtKB: Q9WV60 (UniProtKB/Swiss-Prot),   Q5KU03 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001334161   ⟸   NM_001347232
- Peptide Label: isoform 2
- UniProtKB: E9QAQ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_030105081   ⟸   XM_030249221
- Peptide Label: isoform X1
Ensembl Acc Id: ENSMUSP00000156065   ⟸   ENSMUST00000231437
Ensembl Acc Id: ENSMUSP00000110398   ⟸   ENSMUST00000114750
Ensembl Acc Id: ENSMUSP00000023507   ⟸   ENSMUST00000023507
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WV60-F1-model_v2 AlphaFold Q9WV60 1-420 view protein structure

Promoters
RGD ID:8686174
Promoter ID:EPDNEW_M21118
Type:initiation region
Name:Gsk3b_2
Description:Mus musculus glycogen synthase kinase 3 beta , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M21119  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381638,089,087 - 38,089,147EPDNEW
RGD ID:6827108
Promoter ID:MM_KWN:20967
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000114750,   OTTMUST00000039047
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361638,089,196 - 38,090,647 (+)MPROMDB
RGD ID:8686176
Promoter ID:EPDNEW_M21119
Type:initiation region
Name:Gsk3b_1
Description:Mus musculus glycogen synthase kinase 3 beta , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M21118  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381638,089,526 - 38,089,586EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1861437 AgrOrtholog
Ensembl Genes ENSMUSG00000022812 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000023507 ENTREZGENE
  ENSMUST00000023507.13 UniProtKB/Swiss-Prot
  ENSMUST00000114750 ENTREZGENE
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro GSK-3 UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
  STKc_GSK3 UniProtKB/Swiss-Prot
KEGG Report mmu:56637 UniProtKB/Swiss-Prot
MGD MGI:1861437 ENTREZGENE
NCBI Gene 56637 ENTREZGENE
PANTHER GLYCOGEN SYNTHASE KINASE-3 ALPHA UniProtKB/Swiss-Prot
  PTHR24057:SF8 UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PhenoGen Gsk3b PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A338P6P8_MOUSE UniProtKB/TrEMBL
  E9QAQ5 ENTREZGENE, UniProtKB/TrEMBL
  GSK3B_MOUSE UniProtKB/Swiss-Prot
  Q3TB31_MOUSE UniProtKB/TrEMBL
  Q5KU03 ENTREZGENE, UniProtKB/TrEMBL
  Q9WV60 ENTREZGENE