Ascl3 (achaete-scute family bHLH transcription factor 3) - Rat Genome Database

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Gene: Ascl3 (achaete-scute family bHLH transcription factor 3) Mus musculus
Analyze
Symbol: Ascl3
Name: achaete-scute family bHLH transcription factor 3
RGD ID: 733791
MGI Page MGI
Description: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; salivary gland development; and sensory epithelium regeneration. Acts upstream of or within regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in parotid gland; sublingual gland; submandibular gland; and ureter. Orthologous to human ASCL3 (achaete-scute family bHLH transcription factor 3).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: achaete-scute complex homolog 3; achaete-scute complex homolog-like 3; achaete-scute homolog 3; ASH-3; bHLH transcriptional regulator Sgn-1; bHLHa; bHLHa42; ICRFP703B1614Q5.4; ICRFP703N2430Q5.4; mASH-3; mASH3; MGC129412; MGC129413; Sg; Sgn1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397109,326,672 - 109,330,939 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7109,326,672 - 109,330,933 (-)EnsemblGRCm39 Ensembl
GRCm387109,727,465 - 109,731,732 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7109,727,465 - 109,731,726 (-)EnsemblGRCm38mm10GRCm38
MGSCv377116,870,979 - 116,875,246 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367109,518,642 - 109,522,909 (-)NCBIMGSCv36mm8
Celera7109,701,621 - 109,705,880 (-)NCBICelera
Cytogenetic Map7E3NCBI
cM Map757.46NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Sgn1, a basic helix-loop-helix transcription factor delineates the salivary gland duct cell lineage in mice. Yoshida S, etal., Dev Biol 2001 Dec 15;240(2):517-30.
Additional References at PubMed
PMID:11528126   PMID:11528127   PMID:12477932   PMID:16602821   PMID:17079272   PMID:18287202   PMID:18287559   PMID:18557763   PMID:18572159   PMID:19521566   PMID:20059953   PMID:20211142  
PMID:21267068   PMID:21377457   PMID:21873635   PMID:24952961   PMID:27910949   PMID:30069044  


Genomics

Comparative Map Data
Ascl3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397109,326,672 - 109,330,939 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7109,326,672 - 109,330,933 (-)EnsemblGRCm39 Ensembl
GRCm387109,727,465 - 109,731,732 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7109,727,465 - 109,731,726 (-)EnsemblGRCm38mm10GRCm38
MGSCv377116,870,979 - 116,875,246 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367109,518,642 - 109,522,909 (-)NCBIMGSCv36mm8
Celera7109,701,621 - 109,705,880 (-)NCBICelera
Cytogenetic Map7E3NCBI
cM Map757.46NCBI
ASCL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38118,937,578 - 8,943,016 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl118,937,578 - 8,943,016 (-)EnsemblGRCh38hg38GRCh38
GRCh37118,959,125 - 8,964,563 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36118,915,695 - 8,921,156 (-)NCBINCBI36Build 36hg18NCBI36
Build 34118,915,694 - 8,921,156NCBI
Celera119,078,881 - 9,084,342 (-)NCBICelera
Cytogenetic Map11p15.4NCBI
HuRef118,629,425 - 8,634,887 (-)NCBIHuRef
CHM1_1118,958,058 - 8,963,517 (-)NCBICHM1_1
T2T-CHM13v2.0119,021,751 - 9,027,203 (-)NCBIT2T-CHM13v2.0
Ascl3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81173,190,061 - 173,194,302 (-)NCBIGRCr8
mRatBN7.21163,755,306 - 163,755,951 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1163,754,956 - 163,759,682 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1172,091,948 - 172,092,593 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01179,277,994 - 179,278,639 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01171,960,108 - 171,960,753 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01174,351,413 - 174,355,590 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01181,336,764 - 181,337,409 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41167,345,397 - 167,349,614 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11167,456,059 - 167,456,648 (-)NCBI
Cytogenetic Map1q33NCBI
Ascl3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541424,688,233 - 24,691,361 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541424,688,233 - 24,691,361 (-)NCBIChiLan1.0ChiLan1.0
ASCL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2911,372,606 - 11,376,393 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11111,330,976 - 11,334,741 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0119,066,304 - 9,067,511 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1118,807,814 - 8,813,289 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl118,807,858 - 8,808,403 (-)Ensemblpanpan1.1panPan2
ASCL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12132,295,736 - 32,303,349 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2132,297,197 - 32,297,742 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2131,865,151 - 31,870,054 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02133,170,543 - 33,175,448 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12132,440,212 - 32,444,712 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02132,605,938 - 32,610,840 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02132,899,811 - 32,904,714 (-)NCBIUU_Cfam_GSD_1.0
Ascl3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494753,095,137 - 53,097,617 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365289,129,722 - 9,130,521 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM9B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9462,643 - 521,013 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19518,449 - 519,710 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29585,232 - 588,005 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ASCL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1155,868,503 - 55,869,744 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl155,868,641 - 55,869,183 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038153,556,537 - 153,557,178 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ascl3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247661,081,694 - 1,082,236 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247661,080,948 - 1,082,372 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ascl3
111 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:132
Count of miRNA genes:127
Interacting mature miRNAs:131
Transcripts:ENSMUST00000035372
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357460Vtbt4_mvertebral trabecular bone trait 4 (mouse)Not determined7101693381135693530Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
27226781Tibl3_mtibia length 3, 5 week (mouse)774849748122199223Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)756949748134001729Mouse
1301781Capsq3_mcapsaicin sensitivity related QTL 3 (mouse)Not determined787143137119485380Mouse
14746989Manh62_mmandible shape 62 (mouse)775742528109742528Mouse
11039524Tbbr3_mTrypanosoma brucei brucei response 3 (mouse)7100750722134750843Mouse
27226769Tibl12_mtibia length 12, 10 week (mouse)787249208126499172Mouse
25394573Skmw62_mskeletal muscle weight 62, gastroc (mouse)7106893715110612309Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745161966118693530Mouse
27226765Tibl18_mtibia length 18, 16 week (mouse)781849748126499172Mouse
27226763Feml20_mfemur length 20, 16 week (mouse)785049208124199223Mouse
4142500Morq1_mmodifier of Rs1 QTL 1 (mouse)Not determined80551681114551791Mouse
1301647Elpt_melevated leptin (mouse)Not determined786500186120500329Mouse
13208555Lgth10_mbody length 10 (mouse)751649748125599172Mouse
26884408Bzwq13_mbi-zygomatic width QTL 13, 16 week (mouse)761749748121399223Mouse
1301937Skull10_mskull morphology 10 (mouse)Not determined791482996125483156Mouse
1300528Ssial3_msusceptibility to sialadenitis 3 (mouse)Not determined793391848127392041Mouse
5491192Mobq1_mmultigenic obesity QTL 1 (mouse)Not determined7105250663139250811Mouse
1301566Adip3_madiposity 3 (mouse)Not determined775394215109394346Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)778649748136901729Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
27226790Feml15_mfemur length 15, 10 week (mouse)787249208126499172Mouse
13524852Asrq7a_macoustic startle response 7a (mouse)7105350008139350008Mouse
13524850Asrq7_macoustic startle response 7 (mouse)798394974132394974Mouse
1302062Stheal6_msoft tissue heal 6 (mouse)Not determined787043932121044066Mouse
4141056Lskcn2_mLSK cell number 2 (mouse)Not determined108482996118693530Mouse
26884440Sklq4_mskull length QTL 4, 5 week (mouse)765249748126499172Mouse
27095903Scvln10_msacral vertebrae length 2, 10 week (mouse)781449748126499172Mouse
27226715Metcl3_mmetatarsal-calcaneal length 3, 5 week (mouse)767849748119499223Mouse
26884444Sklq8_mskull length QTL 8, 10 week (mouse)767849748124199223Mouse
25823170Hrsq7_mhost response to SARS QTL 7, log titer (mouse)754819589116822815Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736280015116416877Mouse
10412110Cctq1_mcentral corneal thickness QTL 1 (mouse)Not determined780551681114551791Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1301447Fembm3_mfemoral bone morphometry 3 (mouse)Not determined7100993261134993342Mouse
10412104Tons2_mtongue size 2 (mouse)Not determined799837716133837716Mouse
1301188Heal6_mwound healing/regeneration 6 (mouse)Not determined787043932121044066Mouse
4142312Nilac4_mnicotine induced locomotor activity 4 (mouse)Not determined7102485219136485380Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
1301105Cfld4_mcystic fibrosis lung disease 4 (mouse)Not determined7101693381135693530Mouse
1300721Cfbw3_mcystic fibrosis body weight 3 (mouse)Not determined7101693381135693530Mouse
13524524Bodwtq6_mbody wweight QTL 6 (mouse)7107245693113055693Mouse
27226745Metcl9_mmetatarsal-calcaneal length 9, 10 week (mouse)774849748122199223Mouse
27095930Ulnl10_mulna length 10, 16 week (mouse)780849748126699172Mouse
27095923Pglq3_mpelvic girdle length QTL 3, 5 week (mouse)781249748124199223Mouse
27095916Scvln15_msacral vertebrae length 2, 16 week (mouse)761749748123699223Mouse
1357664Nba3_mNew Zealand Black autoimmunity 3 (mouse)Not determined791482996125483156Mouse
1301478Eae26_msusceptibility to experimental allergic encephalomyelitis 26 (mouse)Not determined798164922132165010Mouse
26884451Sklq14_mskull length QTL 14, 16 week (mouse)767849748124999172Mouse
27095910Pglq13_mpelvic girdle length QTL 13, 16 week (mouse)773049748125699172Mouse
13463473Hbbcq4_mhemoglobin concentration QTL 4 (mouse)787043932121044066Mouse
25394559Skmw63_mskeletal muscle weight 63, TA (mouse)7108791458110612309Mouse
27095907Scvln4_msacral vertebrae length 2, 5 week (mouse)769949748120499223Mouse
1301997Cia7_mcollagen induced arthritis QTL 7 (mouse)Not determined785365595112533819Mouse
25394557Skmw64_mskeletal muscle weight 64, soleus (mouse)7108715780114592736Mouse
35673311Ari6_mantibody response to influenza 6, day 15, IgG2b (mouse)7108699207115099235Mouse
25394556Skmw65_mskeletal muscle weight 65, EDL (mouse)7109059337110612309Mouse

Markers in Region
Ascl3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387109,727,465 - 109,728,117UniSTSGRCm38
Celera7109,701,621 - 109,702,273UniSTS
Cytogenetic Map7E3UniSTS
cM Map757.46UniSTS
Ascl3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7E3UniSTS


Expression


Sequence


Ensembl Acc Id: ENSMUST00000035372   ⟹   ENSMUSP00000037702
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7109,326,672 - 109,330,933 (-)Ensembl
GRCm38.p6 Ensembl7109,727,465 - 109,731,726 (-)Ensembl
RefSeq Acc Id: NM_020051   ⟹   NP_064435
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397109,326,672 - 109,330,939 (-)NCBI
GRCm387109,727,465 - 109,731,732 (-)ENTREZGENE
MGSCv377116,870,979 - 116,875,246 (-)RGD
Celera7109,701,621 - 109,705,880 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_064435   ⟸   NM_020051
- UniProtKB: Q3SXE3 (UniProtKB/Swiss-Prot),   Q9JJR7 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000037702   ⟸   ENSMUST00000035372
Protein Domains
bHLH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JJR7-F1-model_v2 AlphaFold Q9JJR7 1-174 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1928820 AgrOrtholog
Ensembl Genes ENSMUSG00000035951 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000035372 ENTREZGENE
  ENSMUST00000035372.3 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot
InterPro bHLH_dom UniProtKB/Swiss-Prot
  E-box_TF_Regulators UniProtKB/Swiss-Prot
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot
KEGG Report mmu:56787 UniProtKB/Swiss-Prot
MGD MGI:1928820 ENTREZGENE
NCBI Gene 56787 ENTREZGENE
PANTHER BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST UniProtKB/Swiss-Prot
  FACTOR IN THE GERMLINE ALPHA UniProtKB/Swiss-Prot
Pfam HLH UniProtKB/Swiss-Prot
PhenoGen Ascl3 PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot
SMART HLH UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot
UniProt ASCL3_MOUSE UniProtKB/Swiss-Prot
  Q3SXE3 ENTREZGENE
  Q9JJR7 ENTREZGENE
UniProt Secondary Q3SXE3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-22 Ascl3  achaete-scute family bHLH transcription factor 3    achaete-scute complex homolog 3 (Drosophila)  Symbol and/or name change 5135510 APPROVED