Itgb1 (integrin beta 1 (fibronectin receptor beta)) - Rat Genome Database

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Gene: Itgb1 (integrin beta 1 (fibronectin receptor beta)) Mus musculus
Symbol: Itgb1
Name: integrin beta 1 (fibronectin receptor beta)
RGD ID: 733764
Description: Enables integrin binding activity involved in cell-matrix adhesion and signaling receptor activity. Contributes to laminin binding activity. Involved in several processes, including basement membrane organization; cellular response to low-density lipoprotein particle stimulus; and regulation of synapse pruning. Acts upstream of or within with a negative effect on reactive gliosis and regulation of spontaneous synaptic transmission. Acts upstream of or within several processes, including G1/S transition of mitotic cell cycle; circulatory system development; and neuron projection morphogenesis. Located in several cellular components, including intercalated disc; myelin sheath abaxonal region; and sarcolemma. Part of integrin alpha7-beta1 complex and integrin alpha9-beta1 complex. Is active in Schaffer collateral - CA1 synapse and cerebellar climbing fiber to Purkinje cell synapse. Colocalizes with cytoplasmic vesicle; perinuclear region of cytoplasm; and plasma membrane. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and heart. Used to study Hirschsprung's disease. Orthologous to human ITGB1 (integrin subunit beta 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 4633401G24Rik; AA409975; AA960159; CD29; ENSMUSG00000051907; fibronectin receptor subunit beta; Fn; Fnrb; Gm9863; gpIIa; integrin beta-1; VLA-4 subunit beta
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm18928  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm398129,412,135 - 129,460,060 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8129,412,135 - 129,459,681 (+)EnsemblGRCm39 Ensembl
GRCm388128,685,654 - 128,733,579 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8128,685,654 - 128,733,200 (+)EnsemblGRCm38mm10GRCm38
MGSCv378131,209,554 - 131,257,479 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368131,571,871 - 131,619,287 (+)NCBIMGSCv36mm8
Celera8133,002,434 - 133,050,263 (+)NCBICelera
Cytogenetic Map8E2NCBI
cM Map876.09NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP,ISO)
(20S)-ginsenoside Rh1  (ISO)
(24S)-24-hydroxycholesterol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(R)-adrenaline  (ISO)
(S)-nicotine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1,3-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (EXP)
2,4-dinitrotoluene  (ISO)
2,5-hexanedione  (ISO)
2,6-dinitrotoluene  (ISO)
2-deoxy-D-glucose  (ISO)
2-methoxyethanol  (ISO)
2-nitrotoluene  (ISO)
26-hydroxycholesterol  (ISO)
3',5'-cyclic AMP  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
7alpha-hydroxycholesterol  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
alternariol  (ISO)
Altertoxin II  (ISO)
aluminium oxide  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
Arg-Gly-Asp  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
artesunate  (ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
aucubin  (ISO)
beauvericin  (ISO)
benomyl  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-carotene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
blebbistatin  (ISO)
bromochloroacetic acid  (ISO)
bucladesine  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calciol  (EXP)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbendazim  (ISO)
carbon nanotube  (EXP)
carmustine  (ISO)
carvone  (EXP,ISO)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
chrysene  (EXP)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clotrimazole  (ISO)
cocaine  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
crocidolite asbestos  (EXP,ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
diuron  (ISO)
dobutamine  (EXP)
doxorubicin  (ISO)
endosulfan  (ISO)
enniatin  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (EXP)
ethyl trans-caffeate  (ISO)
etodolac  (ISO)
eugenol  (ISO)
fenamidone  (EXP)
fenhexamid  (ISO)
fenofibrate  (ISO)
folic acid  (EXP,ISO)
fructose  (ISO)
fulvestrant  (ISO)
furan  (ISO)
gefitinib  (ISO)
genistein  (EXP,ISO)
geranylgeraniol  (ISO)
ginsenoside C-K  (ISO)
glucose  (EXP,ISO)
glycidyl methacrylate  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (EXP,ISO)
ifosfamide  (ISO)
indirubin  (ISO)
indometacin  (ISO)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
latrunculin A  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (EXP)
lithocholic acid  (ISO)
lovastatin  (EXP)
magnesium atom  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
medroxyprogesterone acetate  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
metformin  (ISO)
methimazole  (ISO)
methotrexate  (EXP,ISO)
methyl methanesulfonate  (ISO)
methylseleninic acid  (EXP)
mevalonic acid  (ISO)
microcystin-LR  (ISO)
ML-7  (ISO)
monocrotaline  (EXP)
morusin  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nicotine  (ISO)
notoginsenoside R1  (EXP)
Octicizer  (ISO)
Ophiopogonin D  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
pentane-2,3-dione  (ISO)
perfluorohexanesulfonic acid  (ISO)
phenobarbital  (ISO)
phenytoin  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP)
potassium iodide  (ISO)
pravastatin  (ISO)
prednisone  (EXP)
progesterone  (ISO)
prostaglandin E2  (ISO)
quercetin  (ISO)
quercitrin  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
rimonabant  (EXP)
rotenone  (ISO)
ruxolitinib  (ISO)
SB 431542  (ISO)
Shikonin  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
spiromesifen  (ISO)
streptozocin  (EXP,ISO)
sulfadimethoxine  (ISO)
superoxide  (EXP)
T-2 toxin  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
trichloroethene  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
tunicamycin  (EXP)
valproic acid  (ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
vorinostat  (ISO)
Y-27632  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
axon extension  (IGI,IMP)
basement membrane organization  (IMP)
bicellular tight junction assembly  (ISO)
calcium-independent cell-matrix adhesion  (ISO)
cardiac cell fate specification  (IMP)
cardiac muscle cell differentiation  (IMP)
cardiac muscle cell myoblast differentiation  (IMP)
CD40 signaling pathway  (ISO)
cell adhesion  (ISO)
cell adhesion mediated by integrin  (IBA,ISO)
cell migration  (IBA)
cell migration involved in sprouting angiogenesis  (IMP)
cell population proliferation  (IMP)
cell projection organization  (ISO)
cell-cell adhesion  (IBA)
cell-cell adhesion mediated by integrin  (ISO)
cell-matrix adhesion  (IBA,IGI,IMP,ISO)
cell-substrate adhesion  (ISO)
cellular response to ionizing radiation  (ISO)
cellular response to low-density lipoprotein particle stimulus  (IDA)
cellular response to mechanical stimulus  (ISO)
cellular response to vitamin D  (ISO)
dendrite morphogenesis  (IGI,IMP)
establishment of mitotic spindle orientation  (ISO)
establishment of Sertoli cell barrier  (ISO)
formation of radial glial scaffolds  (IMP)
G1/S transition of mitotic cell cycle  (IMP)
germ cell migration  (IMP)
heterotypic cell-cell adhesion  (ISO)
in utero embryonic development  (IMP)
integrin-mediated signaling pathway  (IBA,ISO)
lamellipodium assembly  (ISO)
leukocyte cell-cell adhesion  (ISO)
leukocyte tethering or rolling  (ISO)
maintenance of postsynaptic specialization structure  (ISO)
maternal process involved in female pregnancy  (ISO)
mesodermal cell differentiation  (ISO)
modulation of chemical synaptic transmission  (IDA,IMP)
muscle organ development  (IEA)
myoblast fate specification  (IMP)
negative regulation of anoikis  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cell projection organization  (ISO)
negative regulation of neuron differentiation  (IMP,ISO)
negative regulation of Rho protein signal transduction  (IGI)
negative regulation of vasoconstriction  (ISO)
neuroblast proliferation  (IMP)
neuron differentiation  (IMP)
neuron projection development  (IMP)
phagocytosis  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell-substrate adhesion  (ISO)
positive regulation of endocytosis  (ISO)
positive regulation of fibroblast growth factor receptor signaling pathway  (ISO)
positive regulation of fibroblast migration  (ISO)
positive regulation of glutamate uptake involved in transmission of nerve impulse  (IMP)
positive regulation of neuroblast proliferation  (IMP)
positive regulation of neuron differentiation  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of protein localization to plasma membrane  (ISO)
positive regulation of vascular endothelial growth factor signaling pathway  (ISO)
positive regulation of wound healing  (ISO)
protein transport within lipid bilayer  (ISO)
reactive gliosis  (IMP)
receptor internalization  (IDA)
regulation of cell cycle  (IMP)
regulation of collagen catabolic process  (ISO)
regulation of G protein-coupled receptor signaling pathway  (ISO)
regulation of postsynaptic neurotransmitter receptor diffusion trapping  (ISO)
regulation of spontaneous synaptic transmission  (IMP)
regulation of synapse pruning  (IDA,IMP)
response to activity  (ISO)
response to gonadotropin  (ISO)
response to muscle activity  (IDA)
response to nutrient levels  (ISO)
response to transforming growth factor beta  (ISO)
response to xenobiotic stimulus  (ISO)
sarcomere organization  (IMP)
stress fiber assembly  (IMP)
tissue homeostasis  (ISO)
transforming growth factor beta receptor signaling pathway  (IMP)
visual learning  (IGI,IMP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal atrial thrombosis  (IAGP)
abnormal basement membrane morphology  (IAGP)
abnormal Bergmann glial cell morphology  (IAGP)
abnormal blastocoele morphology  (IAGP)
abnormal bone mineralization  (IAGP)
abnormal bone ossification  (IAGP)
abnormal brain morphology  (IAGP)
abnormal Cajal-Retzius cell morphology  (IAGP)
abnormal cardiac mesenchyme morphology  (IAGP)
abnormal cardiac muscle cell glucose uptake  (IAGP)
abnormal cardiac muscle relaxation  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal cartilage development  (IAGP)
abnormal cell adhesion  (IAGP)
abnormal cell cycle  (IAGP)
abnormal cell death  (IAGP)
abnormal cell morphology  (IAGP)
abnormal cell physiology  (IAGP)
abnormal cellular extravasation  (IAGP)
abnormal cerebellar foliation  (IAGP)
abnormal cerebellum development  (IAGP)
abnormal cerebellum external granule cell layer morphology  (IAGP)
abnormal cerebellum fissure morphology  (IAGP)
abnormal cerebellum lobule morphology  (IAGP)
abnormal cerebellum morphology  (IAGP)
abnormal cerebellum vermis morphology  (IAGP)
abnormal cerebral cortex morphology  (IAGP)
abnormal chondrocyte morphology  (IAGP)
abnormal choroid plexus morphology  (IAGP)
abnormal circulating lipid level  (IAGP)
abnormal CNS glial cell morphology  (IAGP)
abnormal coat/ hair morphology  (IAGP)
abnormal cortical marginal zone morphology  (IAGP)
abnormal cranial nerve morphology  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal crypts of Lieberkuhn morphology  (IAGP)
abnormal dendritic cell physiology  (IAGP)
abnormal dermal layer morphology  (IAGP)
abnormal dermal pigmentation  (IAGP)
abnormal digit development  (IAGP)
abnormal ear position  (IAGP)
abnormal ear shape  (IAGP)
abnormal embryo development  (IAGP)
abnormal embryo implantation  (IAGP)
abnormal enteric neural crest cell migration  (IAGP)
abnormal enteric neural crest cell morphology  (IAGP)
abnormal enteric neuron morphology  (IAGP)
abnormal enterocyte morphology  (IAGP)
abnormal epidermal layer morphology  (IAGP)
abnormal epidermal-dermal junction morphology  (IAGP)
abnormal epidermis stratum basale morphology  (IAGP)
abnormal esophageal epithelium morphology  (IAGP)
abnormal eye distance/ position  (IAGP)
abnormal eyelid morphology  (IAGP)
abnormal facial morphology  (IAGP)
abnormal first pharyngeal arch morphology  (IAGP)
abnormal gait  (IAGP)
abnormal glomerular capillary morphology  (IAGP)
abnormal hair follicle development  (IAGP)
abnormal hair follicle morphology  (IAGP)
abnormal hair follicle outer root sheath morphology  (IAGP)
abnormal hair growth  (IAGP)
abnormal head morphology  (IAGP)
abnormal heart morphology  (IAGP)
abnormal heart ventricle morphology  (IAGP)
abnormal inner cell mass morphology  (IAGP)
abnormal innervation  (IAGP)
abnormal innervation pattern to muscle  (IAGP)
abnormal intestinal absorption  (IAGP)
abnormal intestinal epithelium morphology  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal keratinocyte morphology  (IAGP)
abnormal kidney collecting duct morphology  (IAGP)
abnormal kidney cortex morphology  (IAGP)
abnormal kidney medulla morphology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal large intestine morphology  (IAGP)
abnormal left-right axis patterning  (IAGP)
abnormal lens epithelium morphology  (IAGP)
abnormal lens fiber morphology  (IAGP)
abnormal limb morphology  (IAGP)
abnormal long bone epiphyseal plate morphology  (IAGP)
abnormal long bone hypertrophic chondrocyte zone  (IAGP)
abnormal mammary gland growth during lactation  (IAGP)
abnormal mammary gland morphology  (IAGP)
abnormal meninges morphology  (IAGP)
abnormal mitosis  (IAGP)
abnormal motor coordination/balance  (IAGP)
abnormal myelination  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal myocardium layer morphology  (IAGP)
abnormal myogenesis  (IAGP)
abnormal myotube morphology  (IAGP)
abnormal nervous system morphology  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal neuromuscular synapse morphology  (IAGP)
abnormal neuronal migration  (IAGP)
abnormal neuronal precursor cell migration  (IAGP)
abnormal pharyngeal arch morphology  (IAGP)
abnormal placenta labyrinth morphology  (IAGP)
abnormal placenta morphology  (IAGP)
abnormal placental labyrinth vasculature morphology  (IAGP)
abnormal platelet physiology  (IAGP)
abnormal posture  (IAGP)
abnormal radial glial cell morphology  (IAGP)
abnormal renal filtration rate  (IAGP)
abnormal renal glomerular capsule morphology  (IAGP)
abnormal renal glomerulus basement membrane morphology  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal renal transport  (IAGP)
abnormal renal tubule epithelium morphology  (IAGP)
abnormal rostral migratory stream morphology  (IAGP)
abnormal sciatic nerve morphology  (IAGP)
abnormal skeletal muscle morphology  (IAGP)
abnormal skin condition  (IAGP)
abnormal skin pigmentation  (IAGP)
abnormal small intestine morphology  (IAGP)
abnormal spine curvature  (IAGP)
abnormal trophoblast layer morphology  (IAGP)
abnormal tumor morphology  (IAGP)
abnormal tumor susceptibility  (IAGP)
abnormal urine homeostasis  (IAGP)
abnormal visceral endoderm morphology  (IAGP)
absent blastocoele  (IAGP)
absent inner cell mass  (IAGP)
absent kidney  (IAGP)
absent Schwann cell precursors  (IAGP)
absent sebaceous gland  (IAGP)
aganglionic megacolon  (IAGP)
albuminuria  (IAGP)
alopecia  (IAGP)
anemia  (IAGP)
aphakia  (IAGP)
ataxia  (IAGP)
blistering  (IAGP)
cardiac fibrosis  (IAGP)
chondrodystrophy  (IAGP)
cleft palate  (IAGP)
congestive heart failure  (IAGP)
cyanosis  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased cell proliferation  (IAGP)
decreased chondrocyte number  (IAGP)
decreased chondrocyte proliferation  (IAGP)
decreased circulating bicarbonate level  (IAGP)
decreased circulating noradrenaline level  (IAGP)
decreased embryo size  (IAGP)
decreased fetal size  (IAGP)
decreased fibroblast cell migration  (IAGP)
decreased fibroblast proliferation  (IAGP)
decreased hair follicle cell proliferation  (IAGP)
decreased hair follicle number  (IAGP)
decreased heart left ventricle muscle contractility  (IAGP)
decreased hematocrit  (IAGP)
decreased hindbrain size  (IAGP)
decreased incidence of tumors by chemical induction  (IAGP)
decreased keratinocyte adhesion  (IAGP)
decreased keratinocyte migration  (IAGP)
decreased keratinocyte proliferation  (IAGP)
decreased kidney weight  (IAGP)
decreased length of long bones  (IAGP)
decreased locomotor activity  (IAGP)
decreased mammary gland tumor incidence  (IAGP)
decreased metastatic potential  (IAGP)
decreased platelet calcium level  (IAGP)
decreased skeletal muscle fiber number  (IAGP)
decreased skeletal muscle mass  (IAGP)
decreased urine osmolality  (IAGP)
delayed somite formation  (IAGP)
delayed wound healing  (IAGP)
dermal-epidermal separation  (IAGP)
dilated cardiomyopathy  (IAGP)
dilated glomerular capillary  (IAGP)
dilated heart  (IAGP)
dilated heart left ventricle  (IAGP)
dilated heart right ventricle  (IAGP)
dilated kidney collecting duct  (IAGP)
dilated renal tubule  (IAGP)
disorganized pancreatic islets  (IAGP)
disproportionate dwarf  (IAGP)
early cellular replicative senescence  (IAGP)
ectopic cerebellar granule cells  (IAGP)
edema  (IAGP)
embryonic growth arrest  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality before implantation, complete penetrance  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
embryonic lethality, incomplete penetrance  (IAGP)
enlarged hair follicles  (IAGP)
epidermal hyperplasia  (IAGP)
exencephaly  (IAGP)
expanded mesangial matrix  (IAGP)
failure of chorioallantoic fusion  (IAGP)
hemorrhage  (IAGP)
hyperactivity  (IEA)
hypopigmentation  (IAGP)
impaired skin barrier function  (IAGP)
increased apoptosis  (IAGP)
increased blood urea nitrogen level  (IAGP)
increased chondrocyte apoptosis  (IAGP)
increased diameter of long bones  (IAGP)
increased embryonic neuroepithelium thickness  (IAGP)
increased heart atrium size  (IAGP)
increased kidney apoptosis  (IAGP)
increased kidney cell proliferation  (IAGP)
increased mesangial cell number  (IAGP)
increased pancreatic alpha cell number  (IAGP)
increased podocyte apoptosis  (IAGP)
increased response of heart to induced stress  (IAGP)
increased susceptibility to induced morbidity/mortality  (IAGP)
increased urine pH  (IAGP)
increased urine protein level  (IAGP)
infertility  (IAGP)
inner cell mass degeneration  (IAGP)
intestine polyps  (IAGP)
isosthenuria  (IAGP)
kidney failure  (IAGP)
kidney medulla cyst  (IAGP)
kidney medulla hypoplasia  (IAGP)
kinked neural tube  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lethality, complete penetrance  (IAGP)
liver vascular congestion  (IAGP)
mandible hypoplasia  (IAGP)
mesangiolysis  (IAGP)
metabolic acidosis  (IAGP)
micrognathia  (IAGP)
microphthalmia  (IAGP)
muscular atrophy  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
open neural tube  (IAGP)
pale kidney  (IAGP)
pallor  (IAGP)
perianal ulcer  (IAGP)
pericardial effusion  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
pleural effusion  (IAGP)
podocyte foot process effacement  (IAGP)
polyuria  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
preweaning lethality, complete penetrance  (IAGP)
preweaning lethality, incomplete penetrance  (IAGP)
progressive hair loss  (IAGP)
progressive muscle weakness  (IAGP)
radial glial endfoot detachment  (IAGP)
reddish skin  (IAGP)
renal cast  (IAGP)
renal hypoplasia  (IAGP)
renal tubular acidosis  (IAGP)
respiratory distress  (IAGP)
short humerus  (IAGP)
short tibia  (IAGP)
single kidney  (IAGP)
skin inflammation  (IAGP)
skin lesions  (IAGP)
small cerebellum  (IAGP)
small first pharyngeal arch  (IAGP)
small kidney  (IAGP)
small olfactory bulb  (IAGP)
small second pharyngeal arch  (IAGP)
sparse hair  (IAGP)
spina bifida  (IAGP)
steatorrhea  (IAGP)
thick epidermis  (IAGP)
thick ventricular wall  (IAGP)
thin epidermis  (IAGP)
thin skin  (IAGP)
tight skin  (IAGP)
wavy neural tube  (IAGP)

References - curated
# Reference Title Reference Citation
1. Connection between integrins and cell activation in rat adrenal glomerulosa cells: a role for Arg-Gly-Asp peptide in the activation of the p42/p44(mapk) pathway and intracellular calcium. Campbell S, etal., Endocrinology. 2003 Apr;144(4):1486-95.
2. Integrin signaling in inflammatory and neuropathic pain in the rat. Dina OA, etal., Eur J Neurosci. 2004 Feb;19(3):634-42.
3. Primary afferent second messenger cascades interact with specific integrin subunits in producing inflammatory hyperalgesia. Dina OA, etal., Pain. 2005 May;115(1-2):191-203.
4. Reelin glycoprotein: structure, biology and roles in health and disease. Fatemi SH Mol Psychiatry. 2005 Mar;10(3):251-7.
5. Bcl-2 and ß1-integrin predict survival in a tissue microarray of small cell lung cancer. Lawson MH, etal., Br J Cancer. 2010 Nov 23;103(11):1710-5. doi: 10.1038/sj.bjc.6605950. Epub 2010 Nov 9.
6. Integrin ß1 Increases Stem Cell Survival and Cardiac Function after Myocardial Infarction. Li L, etal., Front Pharmacol. 2017 Mar 17;8:135. doi: 10.3389/fphar.2017.00135. eCollection 2017.
7. High expression of miR-493-5p positively correlates with clinical prognosis of non small cell lung cancer by targeting oncogene ITGB1. Liang Z, etal., Oncotarget. 2017 Jul 18;8(29):47389-47399. doi: 10.18632/oncotarget.17650.
8. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
9. MGDs mouse GO annotations MGD data from the GO Consortium
11. Intraventricular injection of antibodies to beta1-integrins generates pressure gradients in the brain favoring hydrocephalus development in rats. Nagra G, etal., Am J Physiol Regul Integr Comp Physiol. 2009 Nov;297(5):R1312-21. Epub 2009 Sep 2.
12. Podocyte foot process effacement in very early phase of passive Heymann nephritis is not a prerequisite for proteinuria. Nosaka H, etal., J Nephrol. 2009 Jul-Aug;22(4):484-90.
13. Increased expression of integrin beta1 is a poor prognostic factor in small-cell lung cancer. Oshita F, etal., Anticancer Res. 2002 Mar-Apr;22(2B):1065-70.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16. Mouse MP Annotation Import Pipeline RGD automated import pipeline
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. The integrins. Takada Y, etal., Genome Biol. 2007;8(5):215.
19. Complex patterns of expression suggest extensive roles for the alpha 2 beta 1 integrin in murine development. Wu JE and Santoro SA, Dev Dyn 1994 Apr;199(4):292-314.
20. Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery Zhong Q, etal., Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2010 Feb;24(2):133-7.
Additional References at PubMed
PMID:1381390   PMID:1431091   PMID:1698797   PMID:1748636   PMID:1833411   PMID:1839357   PMID:2521606   PMID:2523953   PMID:2973567   PMID:3262537   PMID:7493623   PMID:7504677  
PMID:7508365   PMID:7515889   PMID:7525645   PMID:7533171   PMID:7544312   PMID:7544313   PMID:7583004   PMID:7589890   PMID:7594538   PMID:7600577   PMID:7621877   PMID:7626796  
PMID:7671812   PMID:7691492   PMID:7983147   PMID:8043949   PMID:8070619   PMID:8070623   PMID:8081870   PMID:8245132   PMID:8306881   PMID:8360188   PMID:8521519   PMID:8567725  
PMID:8600394   PMID:8601592   PMID:8626034   PMID:8663265   PMID:8682318   PMID:8722691   PMID:8821033   PMID:8834471   PMID:8838570   PMID:8870969   PMID:8915827   PMID:8930896  
PMID:8951069   PMID:8977314   PMID:9004034   PMID:9013328   PMID:9015267   PMID:9016309   PMID:9019241   PMID:9022052   PMID:9054500   PMID:9359872   PMID:9361014   PMID:9388785  
PMID:9415431   PMID:9421166   PMID:9427295   PMID:9427478   PMID:9537266   PMID:9545227   PMID:9553049   PMID:9683634   PMID:9686317   PMID:9698453   PMID:9742403   PMID:9832163  
PMID:9844629   PMID:9858678   PMID:9885280   PMID:9916011   PMID:9925758   PMID:10079228   PMID:10090148   PMID:10091056   PMID:10206722   PMID:10349636   PMID:10433923   PMID:10547352  
PMID:10598816   PMID:10613898   PMID:10634791   PMID:10742111   PMID:10894165   PMID:10906147   PMID:10921880   PMID:10922068   PMID:10939329   PMID:10972224   PMID:10974002   PMID:11042159  
PMID:11044609   PMID:11076861   PMID:11217851   PMID:11223950   PMID:11319859   PMID:11331578   PMID:11371349   PMID:11381080   PMID:11431366   PMID:11438667   PMID:11470398   PMID:11516395  
PMID:11543617   PMID:11544199   PMID:11732910   PMID:11744715   PMID:11777940   PMID:11850066   PMID:11884376   PMID:11911830   PMID:11912004   PMID:11959837   PMID:11980921   PMID:12021063  
PMID:12021259   PMID:12112462   PMID:12183834   PMID:12189152   PMID:12244214   PMID:12354388   PMID:12388754   PMID:12466851   PMID:12477932   PMID:12486108   PMID:12488427   PMID:12496264  
PMID:12519075   PMID:12520002   PMID:12573995   PMID:12586747   PMID:12591243   PMID:12620989   PMID:12629153   PMID:12637511   PMID:12670870   PMID:12690105   PMID:12691739   PMID:12721290  
PMID:12737803   PMID:12773577   PMID:12803239   PMID:12805567   PMID:12837282   PMID:12837626   PMID:12843252   PMID:12844491   PMID:12879062   PMID:12904471   PMID:12904583   PMID:12921739  
PMID:12941630   PMID:12957148   PMID:12960301   PMID:12967561   PMID:14512161   PMID:14516674   PMID:14516789   PMID:14522949   PMID:14552869   PMID:14610273   PMID:14622142   PMID:14645004  
PMID:14688336   PMID:14699139   PMID:14998999   PMID:15023537   PMID:15034138   PMID:15056720   PMID:15102471   PMID:15117962   PMID:15138161   PMID:15153775   PMID:15181153   PMID:15226259  
PMID:15252120   PMID:15253938   PMID:15258770   PMID:15265981   PMID:15324699   PMID:15329344   PMID:15331325   PMID:15361073   PMID:15366018   PMID:15368439   PMID:15370361   PMID:15371519  
PMID:15383613   PMID:15465888   PMID:15466886   PMID:15489334   PMID:15504324   PMID:15525768   PMID:15590642   PMID:15610531   PMID:15611085   PMID:15615721   PMID:15688013   PMID:15703255  
PMID:15713743   PMID:15713750   PMID:15721307   PMID:15723043   PMID:15728252   PMID:15746965   PMID:15817462   PMID:15884052   PMID:15886326   PMID:15889143   PMID:15913604   PMID:15928047  
PMID:15954093   PMID:15976328   PMID:16000373   PMID:16003770   PMID:16054021   PMID:16123222   PMID:16141072   PMID:16141073   PMID:16166590   PMID:16198011   PMID:16258728   PMID:16268053  
PMID:16301336   PMID:16319112   PMID:16332675   PMID:16354192   PMID:16365040   PMID:16369019   PMID:16399691   PMID:16418227   PMID:16424942   PMID:16436605   PMID:16455949   PMID:16467530  
PMID:16501085   PMID:16510507   PMID:16529735   PMID:16533505   PMID:16554364   PMID:16571628   PMID:16575886   PMID:16602821   PMID:16618804   PMID:16636073   PMID:16690036   PMID:16717059  
PMID:16735603   PMID:16754661   PMID:16775606   PMID:16785564   PMID:16855094   PMID:16882656   PMID:16914328   PMID:16917498   PMID:16940438   PMID:16940508   PMID:16954348   PMID:16967503  
PMID:16977325   PMID:16980616   PMID:17023412   PMID:17032923   PMID:17043354   PMID:17060328   PMID:17065460   PMID:17068473   PMID:17079689   PMID:17088430   PMID:17099249   PMID:17118692  
PMID:17237400   PMID:17267546   PMID:17276340   PMID:17301228   PMID:17306631   PMID:17334455   PMID:17339338   PMID:17344408   PMID:17366632   PMID:17377534   PMID:17420280   PMID:17492285  
PMID:17493607   PMID:17507648   PMID:17530710   PMID:17537792   PMID:17541405   PMID:17548654   PMID:17562714   PMID:17576798   PMID:17576799   PMID:17601529   PMID:17616930   PMID:17618648  
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PMID:17901052   PMID:17948866   PMID:17960184   PMID:17984225   PMID:18000613   PMID:18032737   PMID:18037995   PMID:18055553   PMID:18058911   PMID:18077697   PMID:18082680   PMID:18086863  
PMID:18165225   PMID:18198349   PMID:18202311   PMID:18216114   PMID:18216331   PMID:18227284   PMID:18230652   PMID:18245559   PMID:18250451   PMID:18278053   PMID:18289871   PMID:18292208  
PMID:18296493   PMID:18313694   PMID:18328474   PMID:18332223   PMID:18340010   PMID:18343155   PMID:18356808   PMID:18381073   PMID:18431835   PMID:18436621   PMID:18451854   PMID:18469806  
PMID:18480158   PMID:18480266   PMID:18499669   PMID:18503049   PMID:18541700   PMID:18566374   PMID:18573216   PMID:18577581   PMID:18579745   PMID:18590826   PMID:18606782   PMID:18611855  
PMID:18619537   PMID:18622550   PMID:18633440   PMID:18658130   PMID:18662549   PMID:18676816   PMID:18676835   PMID:18692570   PMID:18794329   PMID:18799693   PMID:18802456   PMID:18804439  
PMID:18832573   PMID:18983968   PMID:18990704   PMID:19056886   PMID:19064993   PMID:19103643   PMID:19104148   PMID:19118216   PMID:19118220   PMID:19118221   PMID:19126201   PMID:19126672  
PMID:19129508   PMID:19132244   PMID:19144637   PMID:19160486   PMID:19176588   PMID:19176753   PMID:19179279   PMID:19192113   PMID:19193855   PMID:19217425   PMID:19240021   PMID:19252491  
PMID:19300477   PMID:19338281   PMID:19342448   PMID:19346499   PMID:19347869   PMID:19373938   PMID:19379667   PMID:19383784   PMID:19416892   PMID:19424505   PMID:19427292   PMID:19439520  
PMID:19443705   PMID:19451276   PMID:19454481   PMID:19458188   PMID:19470583   PMID:19487454   PMID:19502425   PMID:19515914   PMID:19535581   PMID:19555977   PMID:19576795   PMID:19586917  
PMID:19587159   PMID:19633169   PMID:19633172   PMID:19652092   PMID:19668337   PMID:19688041   PMID:19710172   PMID:19714619   PMID:19725119   PMID:19726564   PMID:19769957   PMID:19783738  
PMID:19789387   PMID:19793892   PMID:19797768   PMID:19805288   PMID:19812190   PMID:19815553   PMID:19821765   PMID:19839056   PMID:19840869   PMID:19887442   PMID:20033667   PMID:20052668  
PMID:20081050   PMID:20087368   PMID:20093499   PMID:20097443   PMID:20103531   PMID:20105241   PMID:20118278   PMID:20152176   PMID:20160019   PMID:20164359   PMID:20179098   PMID:20188101  
PMID:20197418   PMID:20237282   PMID:20368353   PMID:20371608   PMID:20380881   PMID:20382852   PMID:20385709   PMID:20388801   PMID:20406330   PMID:20407016   PMID:20483748   PMID:20483780  
PMID:20493807   PMID:20592186   PMID:20639577   PMID:20651280   PMID:20677223   PMID:20709799   PMID:20713705   PMID:20713715   PMID:20720202   PMID:20802515   PMID:20813881   PMID:20813953  
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PMID:21897373   PMID:21903667   PMID:21903675   PMID:21921419   PMID:21936403   PMID:21945075   PMID:21947080   PMID:21979816   PMID:21983115   PMID:22038049   PMID:22103309   PMID:22153897  
PMID:22157817   PMID:22160594   PMID:22198504   PMID:22198947   PMID:22210772   PMID:22228097   PMID:22247553   PMID:22248583   PMID:22274697   PMID:22287577   PMID:22331032   PMID:22331870  
PMID:22342243   PMID:22357865   PMID:22374686   PMID:22430151   PMID:22472609   PMID:22488504   PMID:22492727   PMID:22496232   PMID:22511753   PMID:22560297   PMID:22561348   PMID:22648512  
PMID:22654117   PMID:22666383   PMID:22683734   PMID:22689267   PMID:22728432   PMID:22748100   PMID:22761447   PMID:22767228   PMID:22767514   PMID:22772469   PMID:22807400   PMID:22829980  
PMID:22869523   PMID:22878525   PMID:22908313   PMID:22918955   PMID:22923640   PMID:22973009   PMID:22982319   PMID:22989875   PMID:23011393   PMID:23015592   PMID:23023225   PMID:23041440  
PMID:23069938   PMID:23100420   PMID:23118221   PMID:23152823   PMID:23175628   PMID:23175850   PMID:23190902   PMID:23226541   PMID:23236519   PMID:23250208   PMID:23263281   PMID:23266827  
PMID:23285215   PMID:23299940   PMID:23305098   PMID:23325811   PMID:23349620   PMID:23359252   PMID:23359821   PMID:23382219   PMID:23385480   PMID:23395392   PMID:23395612   PMID:23395910  
PMID:23497137   PMID:23509351   PMID:23515331   PMID:23523587   PMID:23552075   PMID:23559562   PMID:23562267   PMID:23578932   PMID:23593489   PMID:23608456   PMID:23620790   PMID:23632027  
PMID:23642664   PMID:23680479   PMID:23685250   PMID:23692868   PMID:23702582   PMID:23708002   PMID:23708969   PMID:23709605   PMID:23715271   PMID:23720740   PMID:23722005   PMID:23744351  
PMID:23764511   PMID:23789592   PMID:23791818   PMID:23797810   PMID:23812936   PMID:23814067   PMID:23863477   PMID:23887637   PMID:23911822   PMID:23911870   PMID:23923962   PMID:23925489  
PMID:23936390   PMID:23999380   PMID:24004668   PMID:24006257   PMID:24006485   PMID:24036928   PMID:24044949   PMID:24065117   PMID:24077284   PMID:24091324   PMID:24244022   PMID:24256316  
PMID:24277939   PMID:24289792   PMID:24317509   PMID:24338367   PMID:24344238   PMID:24344262   PMID:24371086   PMID:24375788   PMID:24390135   PMID:24495803   PMID:24505282   PMID:24509849  
PMID:24518294   PMID:24531548   PMID:24551245   PMID:24559672   PMID:24598164   PMID:24611815   PMID:24614228   PMID:24659687   PMID:24681597   PMID:24687281   PMID:24694902   PMID:24705394  
PMID:24706882   PMID:24749073   PMID:24831527   PMID:24833794   PMID:24844558   PMID:24858485   PMID:24939421   PMID:24952961   PMID:25084151   PMID:25089569   PMID:25098415   PMID:25145933  
PMID:25180193   PMID:25183373   PMID:25202019   PMID:25242040   PMID:25278023   PMID:25342668   PMID:25355554   PMID:25395457   PMID:25416549   PMID:25504047   PMID:25511181   PMID:25545242  
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PMID:25808491   PMID:25808553   PMID:25830530   PMID:25830763   PMID:25854700   PMID:25911095   PMID:25925201   PMID:25995225   PMID:25997909   PMID:26027930   PMID:26071356   PMID:26085643  
PMID:26120030   PMID:26120033   PMID:26143257   PMID:26148229   PMID:26151572   PMID:26188246   PMID:26212757   PMID:26247610   PMID:26352002   PMID:26358409   PMID:26434918   PMID:26436690  
PMID:26456333   PMID:26496610   PMID:26529256   PMID:26595647   PMID:26610862   PMID:26641717   PMID:26644476   PMID:26659448   PMID:26681494   PMID:26702126   PMID:26733533   PMID:26801741  
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PMID:27228460   PMID:27314666   PMID:27370713   PMID:27371534   PMID:27376575   PMID:27427791   PMID:27438371   PMID:27449702   PMID:27535340   PMID:27542621   PMID:27562932   PMID:27596755  
PMID:27627840   PMID:27653694   PMID:27693578   PMID:27718357   PMID:27810956   PMID:27861803   PMID:27905407   PMID:27940654   PMID:27990663   PMID:28111199   PMID:28153048   PMID:28153772  
PMID:28175314   PMID:28218908   PMID:28251149   PMID:28266574   PMID:28281529   PMID:28289267   PMID:28340616   PMID:28370666   PMID:28417486   PMID:28465335   PMID:28536193   PMID:28536952  
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