Itgb1 (integrin beta 1 (fibronectin receptor beta)) - Rat Genome Database

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Gene: Itgb1 (integrin beta 1 (fibronectin receptor beta)) Mus musculus
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Symbol: Itgb1
Name: integrin beta 1 (fibronectin receptor beta)
RGD ID: 733764
MGI Page MGI
Description: Enables integrin binding activity involved in cell-matrix adhesion and signaling receptor activity. Contributes to laminin binding activity. Involved in several processes, including basement membrane organization; cellular response to low-density lipoprotein particle stimulus; and regulation of synapse pruning. Acts upstream of or within with a negative effect on reactive gliosis and regulation of spontaneous synaptic transmission. Acts upstream of or within several processes, including G1/S transition of mitotic cell cycle; circulatory system development; and neuron projection morphogenesis. Located in several cellular components, including intercalated disc; myelin sheath abaxonal region; and sarcolemma. Part of integrin alpha7-beta1 complex and integrin alpha9-beta1 complex. Is active in Schaffer collateral - CA1 synapse and cerebellar climbing fiber to Purkinje cell synapse. Colocalizes with cytoplasmic vesicle; perinuclear region of cytoplasm; and plasma membrane. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and heart. Used to study Hirschsprung's disease. Orthologous to human ITGB1 (integrin subunit beta 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 4633401G24Rik; AA409975; AA960159; CD29; ENSMUSG00000051907; fibronectin receptor subunit beta; Fn; Fnrb; Gm9863; gpIIa; integrin beta-1; VLA-4 subunit beta
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm18928  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398129,412,135 - 129,460,060 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8129,412,135 - 129,459,681 (+)EnsemblGRCm39 Ensembl
GRCm388128,685,654 - 128,733,579 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8128,685,654 - 128,733,200 (+)EnsemblGRCm38mm10GRCm38
MGSCv378131,209,554 - 131,257,479 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368131,571,871 - 131,619,287 (+)NCBIMGSCv36mm8
Celera8133,002,434 - 133,050,263 (+)NCBICelera
Cytogenetic Map8E2NCBI
cM Map876.09NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP,ISO)
(20S)-ginsenoside Rh1  (ISO)
(24S)-24-hydroxycholesterol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(R)-adrenaline  (ISO)
(S)-nicotine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1,3-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (EXP)
2,4-dinitrotoluene  (ISO)
2,5-hexanedione  (ISO)
2,6-dinitrotoluene  (ISO)
2-deoxy-D-glucose  (ISO)
2-methoxyethanol  (ISO)
2-nitrotoluene  (ISO)
26-hydroxycholesterol  (ISO)
3',5'-cyclic AMP  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
7alpha-hydroxycholesterol  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
alternariol  (ISO)
Altertoxin II  (ISO)
aluminium oxide  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
Arg-Gly-Asp  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
artesunate  (ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
aucubin  (ISO)
beauvericin  (ISO)
benomyl  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-carotene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
blebbistatin  (ISO)
bromochloroacetic acid  (ISO)
bucladesine  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calciol  (EXP)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbendazim  (ISO)
carbon nanotube  (EXP)
carmustine  (ISO)
carvone  (EXP,ISO)
CEDRELONE  (ISO)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
chrysene  (EXP)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clotrimazole  (ISO)
cocaine  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
crocidolite asbestos  (EXP,ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
DDT  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
diuron  (ISO)
dobutamine  (EXP)
doxorubicin  (ISO)
endosulfan  (ISO)
enniatin  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (EXP)
ethyl trans-caffeate  (ISO)
etodolac  (ISO)
eugenol  (ISO)
fenamidone  (EXP)
fenhexamid  (ISO)
fenofibrate  (ISO)
folic acid  (EXP,ISO)
fructose  (ISO)
fulvestrant  (ISO)
furan  (ISO)
gefitinib  (ISO)
genistein  (EXP,ISO)
geranylgeraniol  (ISO)
ginsenoside C-K  (ISO)
glucose  (EXP,ISO)
glycidyl methacrylate  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (EXP,ISO)
ifosfamide  (ISO)
indirubin  (ISO)
indometacin  (ISO)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
latrunculin A  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (EXP)
lithocholic acid  (ISO)
lovastatin  (EXP)
magnesium atom  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
medroxyprogesterone acetate  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
metformin  (ISO)
methimazole  (ISO)
methotrexate  (EXP,ISO)
methyl methanesulfonate  (ISO)
methylseleninic acid  (EXP)
mevalonic acid  (ISO)
microcystin-LR  (ISO)
ML-7  (ISO)
monocrotaline  (EXP)
morusin  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nicotine  (ISO)
notoginsenoside R1  (EXP)
Octicizer  (ISO)
Ophiopogonin D  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
pentane-2,3-dione  (ISO)
perfluorohexanesulfonic acid  (ISO)
phenobarbital  (ISO)
phenytoin  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP)
potassium iodide  (ISO)
pravastatin  (ISO)
prednisone  (EXP)
progesterone  (ISO)
prostaglandin E2  (ISO)
quercetin  (ISO)
quercitrin  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
rimonabant  (EXP)
rotenone  (ISO)
ruxolitinib  (ISO)
SB 431542  (ISO)
Shikonin  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
spiromesifen  (ISO)
streptozocin  (EXP,ISO)
sulfadimethoxine  (ISO)
superoxide  (EXP)
T-2 toxin  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
trichloroethene  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
tunicamycin  (EXP)
valproic acid  (ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
vorinostat  (ISO)
Y-27632  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
axon extension  (IGI,IMP)
basement membrane organization  (IMP)
bicellular tight junction assembly  (ISO)
calcium-independent cell-matrix adhesion  (ISO)
cardiac cell fate specification  (IMP)
cardiac muscle cell differentiation  (IMP)
cardiac muscle cell myoblast differentiation  (IMP)
CD40 signaling pathway  (ISO)
cell adhesion  (ISO)
cell adhesion mediated by integrin  (IBA,ISO)
cell migration  (IBA)
cell migration involved in sprouting angiogenesis  (IMP)
cell population proliferation  (IMP)
cell projection organization  (ISO)
cell-cell adhesion  (IBA)
cell-cell adhesion mediated by integrin  (ISO)
cell-matrix adhesion  (IBA,IGI,IMP,ISO)
cell-substrate adhesion  (ISO)
cellular response to ionizing radiation  (ISO)
cellular response to low-density lipoprotein particle stimulus  (IDA)
cellular response to mechanical stimulus  (ISO)
cellular response to vitamin D  (ISO)
dendrite morphogenesis  (IGI,IMP)
establishment of mitotic spindle orientation  (ISO)
establishment of Sertoli cell barrier  (ISO)
formation of radial glial scaffolds  (IMP)
G1/S transition of mitotic cell cycle  (IMP)
germ cell migration  (IMP)
heterotypic cell-cell adhesion  (ISO)
in utero embryonic development  (IMP)
integrin-mediated signaling pathway  (IBA,ISO)
lamellipodium assembly  (ISO)
leukocyte cell-cell adhesion  (ISO)
leukocyte tethering or rolling  (ISO)
maintenance of postsynaptic specialization structure  (ISO)
maternal process involved in female pregnancy  (ISO)
mesodermal cell differentiation  (ISO)
modulation of chemical synaptic transmission  (IDA,IMP)
muscle organ development  (IEA)
myoblast fate specification  (IMP)
negative regulation of anoikis  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cell projection organization  (ISO)
negative regulation of neuron differentiation  (IMP,ISO)
negative regulation of Rho protein signal transduction  (IGI)
negative regulation of vasoconstriction  (ISO)
neuroblast proliferation  (IMP)
neuron differentiation  (IMP)
neuron projection development  (IMP)
phagocytosis  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell-substrate adhesion  (ISO)
positive regulation of endocytosis  (ISO)
positive regulation of fibroblast growth factor receptor signaling pathway  (ISO)
positive regulation of fibroblast migration  (ISO)
positive regulation of glutamate uptake involved in transmission of nerve impulse  (IMP)
positive regulation of neuroblast proliferation  (IMP)
positive regulation of neuron differentiation  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of protein localization to plasma membrane  (ISO)
positive regulation of vascular endothelial growth factor signaling pathway  (ISO)
positive regulation of wound healing  (ISO)
protein transport within lipid bilayer  (ISO)
reactive gliosis  (IMP)
receptor internalization  (IDA)
regulation of cell cycle  (IMP)
regulation of collagen catabolic process  (ISO)
regulation of G protein-coupled receptor signaling pathway  (ISO)
regulation of postsynaptic neurotransmitter receptor diffusion trapping  (ISO)
regulation of spontaneous synaptic transmission  (IMP)
regulation of synapse pruning  (IDA,IMP)
response to activity  (ISO)
response to gonadotropin  (ISO)
response to muscle activity  (IDA)
response to nutrient levels  (ISO)
response to transforming growth factor beta  (ISO)
response to xenobiotic stimulus  (ISO)
sarcomere organization  (IMP)
stress fiber assembly  (IMP)
tissue homeostasis  (ISO)
transforming growth factor beta receptor signaling pathway  (IMP)
visual learning  (IGI,IMP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal atrial thrombosis  (IAGP)
abnormal basement membrane morphology  (IAGP)
abnormal Bergmann glial cell morphology  (IAGP)
abnormal blastocoele morphology  (IAGP)
abnormal bone mineralization  (IAGP)
abnormal bone ossification  (IAGP)
abnormal brain morphology  (IAGP)
abnormal Cajal-Retzius cell morphology  (IAGP)
abnormal cardiac mesenchyme morphology  (IAGP)
abnormal cardiac muscle cell glucose uptake  (IAGP)
abnormal cardiac muscle relaxation  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal cartilage development  (IAGP)
abnormal cell adhesion  (IAGP)
abnormal cell cycle  (IAGP)
abnormal cell death  (IAGP)
abnormal cell morphology  (IAGP)
abnormal cell physiology  (IAGP)
abnormal cellular extravasation  (IAGP)
abnormal cerebellar foliation  (IAGP)
abnormal cerebellum development  (IAGP)
abnormal cerebellum external granule cell layer morphology  (IAGP)
abnormal cerebellum fissure morphology  (IAGP)
abnormal cerebellum lobule morphology  (IAGP)
abnormal cerebellum morphology  (IAGP)
abnormal cerebellum vermis morphology  (IAGP)
abnormal cerebral cortex morphology  (IAGP)
abnormal chondrocyte morphology  (IAGP)
abnormal choroid plexus morphology  (IAGP)
abnormal circulating lipid level  (IAGP)
abnormal CNS glial cell morphology  (IAGP)
abnormal coat/ hair morphology  (IAGP)
abnormal cortical marginal zone morphology  (IAGP)
abnormal cranial nerve morphology  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal crypts of Lieberkuhn morphology  (IAGP)
abnormal dendritic cell physiology  (IAGP)
abnormal dermal layer morphology  (IAGP)
abnormal dermal pigmentation  (IAGP)
abnormal digit development  (IAGP)
abnormal ear position  (IAGP)
abnormal ear shape  (IAGP)
abnormal embryo development  (IAGP)
abnormal embryo implantation  (IAGP)
abnormal enteric neural crest cell migration  (IAGP)
abnormal enteric neural crest cell morphology  (IAGP)
abnormal enteric neuron morphology  (IAGP)
abnormal enterocyte morphology  (IAGP)
abnormal epidermal layer morphology  (IAGP)
abnormal epidermal-dermal junction morphology  (IAGP)
abnormal epidermis stratum basale morphology  (IAGP)
abnormal esophageal epithelium morphology  (IAGP)
abnormal eye distance/ position  (IAGP)
abnormal eyelid morphology  (IAGP)
abnormal facial morphology  (IAGP)
abnormal first pharyngeal arch morphology  (IAGP)
abnormal gait  (IAGP)
abnormal glomerular capillary morphology  (IAGP)
abnormal hair follicle development  (IAGP)
abnormal hair follicle morphology  (IAGP)
abnormal hair follicle outer root sheath morphology  (IAGP)
abnormal hair growth  (IAGP)
abnormal head morphology  (IAGP)
abnormal heart morphology  (IAGP)
abnormal heart ventricle morphology  (IAGP)
abnormal inner cell mass morphology  (IAGP)
abnormal innervation  (IAGP)
abnormal innervation pattern to muscle  (IAGP)
abnormal intestinal absorption  (IAGP)
abnormal intestinal epithelium morphology  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal keratinocyte morphology  (IAGP)
abnormal kidney collecting duct morphology  (IAGP)
abnormal kidney cortex morphology  (IAGP)
abnormal kidney medulla morphology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal large intestine morphology  (IAGP)
abnormal left-right axis patterning  (IAGP)
abnormal lens epithelium morphology  (IAGP)
abnormal lens fiber morphology  (IAGP)
abnormal limb morphology  (IAGP)
abnormal long bone epiphyseal plate morphology  (IAGP)
abnormal long bone hypertrophic chondrocyte zone  (IAGP)
abnormal mammary gland growth during lactation  (IAGP)
abnormal mammary gland morphology  (IAGP)
abnormal meninges morphology  (IAGP)
abnormal mitosis  (IAGP)
abnormal motor coordination/balance  (IAGP)
abnormal myelination  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal myocardium layer morphology  (IAGP)
abnormal myogenesis  (IAGP)
abnormal myotube morphology  (IAGP)
abnormal nervous system morphology  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal neuromuscular synapse morphology  (IAGP)
abnormal neuronal migration  (IAGP)
abnormal neuronal precursor cell migration  (IAGP)
abnormal pharyngeal arch morphology  (IAGP)
abnormal placenta labyrinth morphology  (IAGP)
abnormal placenta morphology  (IAGP)
abnormal placental labyrinth vasculature morphology  (IAGP)
abnormal platelet physiology  (IAGP)
abnormal posture  (IAGP)
abnormal radial glial cell morphology  (IAGP)
abnormal renal filtration rate  (IAGP)
abnormal renal glomerular capsule morphology  (IAGP)
abnormal renal glomerulus basement membrane morphology  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal renal transport  (IAGP)
abnormal renal tubule epithelium morphology  (IAGP)
abnormal rostral migratory stream morphology  (IAGP)
abnormal sciatic nerve morphology  (IAGP)
abnormal skeletal muscle morphology  (IAGP)
abnormal skin condition  (IAGP)
abnormal skin pigmentation  (IAGP)
abnormal small intestine morphology  (IAGP)
abnormal spine curvature  (IAGP)
abnormal trophoblast layer morphology  (IAGP)
abnormal tumor morphology  (IAGP)
abnormal tumor susceptibility  (IAGP)
abnormal urine homeostasis  (IAGP)
abnormal visceral endoderm morphology  (IAGP)
absent blastocoele  (IAGP)
absent inner cell mass  (IAGP)
absent kidney  (IAGP)
absent Schwann cell precursors  (IAGP)
absent sebaceous gland  (IAGP)
aganglionic megacolon  (IAGP)
albuminuria  (IAGP)
alopecia  (IAGP)
anemia  (IAGP)
aphakia  (IAGP)
ataxia  (IAGP)
blistering  (IAGP)
cardiac fibrosis  (IAGP)
chondrodystrophy  (IAGP)
cleft palate  (IAGP)
congestive heart failure  (IAGP)
cyanosis  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased cell proliferation  (IAGP)
decreased chondrocyte number  (IAGP)
decreased chondrocyte proliferation  (IAGP)
decreased circulating bicarbonate level  (IAGP)
decreased circulating noradrenaline level  (IAGP)
decreased embryo size  (IAGP)
decreased fetal size  (IAGP)
decreased fibroblast cell migration  (IAGP)
decreased fibroblast proliferation  (IAGP)
decreased hair follicle cell proliferation  (IAGP)
decreased hair follicle number  (IAGP)
decreased heart left ventricle muscle contractility  (IAGP)
decreased hematocrit  (IAGP)
decreased hindbrain size  (IAGP)
decreased incidence of tumors by chemical induction  (IAGP)
decreased keratinocyte adhesion  (IAGP)
decreased keratinocyte migration  (IAGP)
decreased keratinocyte proliferation  (IAGP)
decreased kidney weight  (IAGP)
decreased length of long bones  (IAGP)
decreased locomotor activity  (IAGP)
decreased mammary gland tumor incidence  (IAGP)
decreased metastatic potential  (IAGP)
decreased platelet calcium level  (IAGP)
decreased skeletal muscle fiber number  (IAGP)
decreased skeletal muscle mass  (IAGP)
decreased urine osmolality  (IAGP)
delayed somite formation  (IAGP)
delayed wound healing  (IAGP)
dermal-epidermal separation  (IAGP)
dilated cardiomyopathy  (IAGP)
dilated glomerular capillary  (IAGP)
dilated heart  (IAGP)
dilated heart left ventricle  (IAGP)
dilated heart right ventricle  (IAGP)
dilated kidney collecting duct  (IAGP)
dilated renal tubule  (IAGP)
disorganized pancreatic islets  (IAGP)
disproportionate dwarf  (IAGP)
early cellular replicative senescence  (IAGP)
ectopic cerebellar granule cells  (IAGP)
edema  (IAGP)
embryonic growth arrest  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality before implantation, complete penetrance  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
embryonic lethality, incomplete penetrance  (IAGP)
enlarged hair follicles  (IAGP)
epidermal hyperplasia  (IAGP)
exencephaly  (IAGP)
expanded mesangial matrix  (IAGP)
failure of chorioallantoic fusion  (IAGP)
hemorrhage  (IAGP)
hyperactivity  (IEA)
hypopigmentation  (IAGP)
impaired skin barrier function  (IAGP)
increased apoptosis  (IAGP)
increased blood urea nitrogen level  (IAGP)
increased chondrocyte apoptosis  (IAGP)
increased diameter of long bones  (IAGP)
increased embryonic neuroepithelium thickness  (IAGP)
increased heart atrium size  (IAGP)
increased kidney apoptosis  (IAGP)
increased kidney cell proliferation  (IAGP)
increased mesangial cell number  (IAGP)
increased pancreatic alpha cell number  (IAGP)
increased podocyte apoptosis  (IAGP)
increased response of heart to induced stress  (IAGP)
increased susceptibility to induced morbidity/mortality  (IAGP)
increased urine pH  (IAGP)
increased urine protein level  (IAGP)
infertility  (IAGP)
inner cell mass degeneration  (IAGP)
intestine polyps  (IAGP)
isosthenuria  (IAGP)
kidney failure  (IAGP)
kidney medulla cyst  (IAGP)
kidney medulla hypoplasia  (IAGP)
kinked neural tube  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lethality, complete penetrance  (IAGP)
liver vascular congestion  (IAGP)
mandible hypoplasia  (IAGP)
mesangiolysis  (IAGP)
metabolic acidosis  (IAGP)
micrognathia  (IAGP)
microphthalmia  (IAGP)
muscular atrophy  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
open neural tube  (IAGP)
pale kidney  (IAGP)
pallor  (IAGP)
perianal ulcer  (IAGP)
pericardial effusion  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
pleural effusion  (IAGP)
podocyte foot process effacement  (IAGP)
polyuria  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
preweaning lethality, complete penetrance  (IAGP)
preweaning lethality, incomplete penetrance  (IAGP)
progressive hair loss  (IAGP)
progressive muscle weakness  (IAGP)
radial glial endfoot detachment  (IAGP)
reddish skin  (IAGP)
renal cast  (IAGP)
renal hypoplasia  (IAGP)
renal tubular acidosis  (IAGP)
respiratory distress  (IAGP)
short humerus  (IAGP)
short tibia  (IAGP)
single kidney  (IAGP)
skin inflammation  (IAGP)
skin lesions  (IAGP)
small cerebellum  (IAGP)
small first pharyngeal arch  (IAGP)
small kidney  (IAGP)
small olfactory bulb  (IAGP)
small second pharyngeal arch  (IAGP)
sparse hair  (IAGP)
spina bifida  (IAGP)
steatorrhea  (IAGP)
thick epidermis  (IAGP)
thick ventricular wall  (IAGP)
thin epidermis  (IAGP)
thin skin  (IAGP)
tight skin  (IAGP)
wavy neural tube  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Connection between integrins and cell activation in rat adrenal glomerulosa cells: a role for Arg-Gly-Asp peptide in the activation of the p42/p44(mapk) pathway and intracellular calcium. Campbell S, etal., Endocrinology. 2003 Apr;144(4):1486-95.
2. Integrin signaling in inflammatory and neuropathic pain in the rat. Dina OA, etal., Eur J Neurosci. 2004 Feb;19(3):634-42.
3. Primary afferent second messenger cascades interact with specific integrin subunits in producing inflammatory hyperalgesia. Dina OA, etal., Pain. 2005 May;115(1-2):191-203.
4. Reelin glycoprotein: structure, biology and roles in health and disease. Fatemi SH Mol Psychiatry. 2005 Mar;10(3):251-7.
5. Bcl-2 and ß1-integrin predict survival in a tissue microarray of small cell lung cancer. Lawson MH, etal., Br J Cancer. 2010 Nov 23;103(11):1710-5. doi: 10.1038/sj.bjc.6605950. Epub 2010 Nov 9.
6. Integrin ß1 Increases Stem Cell Survival and Cardiac Function after Myocardial Infarction. Li L, etal., Front Pharmacol. 2017 Mar 17;8:135. doi: 10.3389/fphar.2017.00135. eCollection 2017.
7. High expression of miR-493-5p positively correlates with clinical prognosis of non small cell lung cancer by targeting oncogene ITGB1. Liang Z, etal., Oncotarget. 2017 Jul 18;8(29):47389-47399. doi: 10.18632/oncotarget.17650.
8. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
9. MGDs mouse GO annotations MGD data from the GO Consortium
10. MGD IEA MGD IEA
11. Intraventricular injection of antibodies to beta1-integrins generates pressure gradients in the brain favoring hydrocephalus development in rats. Nagra G, etal., Am J Physiol Regul Integr Comp Physiol. 2009 Nov;297(5):R1312-21. Epub 2009 Sep 2.
12. Podocyte foot process effacement in very early phase of passive Heymann nephritis is not a prerequisite for proteinuria. Nosaka H, etal., J Nephrol. 2009 Jul-Aug;22(4):484-90.
13. Increased expression of integrin beta1 is a poor prognostic factor in small-cell lung cancer. Oshita F, etal., Anticancer Res. 2002 Mar-Apr;22(2B):1065-70.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16. Mouse MP Annotation Import Pipeline RGD automated import pipeline
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. The integrins. Takada Y, etal., Genome Biol. 2007;8(5):215.
19. Complex patterns of expression suggest extensive roles for the alpha 2 beta 1 integrin in murine development. Wu JE and Santoro SA, Dev Dyn 1994 Apr;199(4):292-314.
20. Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery Zhong Q, etal., Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2010 Feb;24(2):133-7.
Additional References at PubMed
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