Rock1 (Rho-associated coiled-coil containing protein kinase 1) - Rat Genome Database

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Gene: Rock1 (Rho-associated coiled-coil containing protein kinase 1) Mus musculus
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Symbol: Rock1
Name: Rho-associated coiled-coil containing protein kinase 1
RGD ID: 733752
MGI Page MGI
Description: Predicted to enable Rho-dependent protein serine/threonine kinase activity; aspartic-type endopeptidase inhibitor activity; and small GTPase binding activity. Involved in several processes, including podocyte cell migration; positive regulation of focal adhesion assembly; and response to angiotensin. Acts upstream of or within several processes, including apical constriction; bleb assembly; and negative regulation of motor neuron apoptotic process. Located in several cellular components, including cytoplasmic stress granule; lamellipodium; and ruffle. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including central nervous system; genitourinary system; gut; heart; and skeletal muscle. Orthologous to human ROCK1 (Rho associated coiled-coil containing protein kinase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1110055K06Rik; p160 ROCK-1; p160ROCK; Rho-associated coiled-coil forming kinase 1; rho-associated protein kinase 1; rho-associated, coiled-coil-containing protein kinase 1; rho-associated, coiled-coil-containing protein kinase I; Roc; Rock-I
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm5374  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391810,064,401 - 10,182,225 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1810,064,401 - 10,182,045 (-)EnsemblGRCm39 Ensembl
GRCm381810,064,401 - 10,182,251 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1810,064,401 - 10,182,045 (-)EnsemblGRCm38mm10GRCm38
MGSCv371810,064,399 - 10,181,790 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361810,067,465 - 10,181,315 (-)NCBIMGSCv36mm8
Celera1810,094,528 - 10,211,725 (-)NCBICelera
Cytogenetic Map18A1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,8-cineole  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-vinylcyclohexene dioxide  (EXP)
5-aza-2'-deoxycytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
Alkannin  (EXP,ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
aspartame  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
Brodifacoum  (ISO)
bufalin  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calciol  (EXP)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
chromium atom  (ISO)
cisplatin  (ISO)
clobetasol  (EXP)
clofibric acid  (ISO)
cobalt dichloride  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP)
D-glucose  (EXP,ISO)
daunorubicin  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
emodin  (ISO)
endosulfan  (ISO)
ethanol  (EXP)
fasudil  (EXP,ISO)
gentamycin  (ISO)
Ginkgoic acid  (ISO)
glucose  (EXP,ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
hyaluronic acid  (ISO)
hypochlorous acid  (EXP)
ivermectin  (ISO)
lead diacetate  (EXP)
maneb  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (EXP)
methylmercury(1+)  (ISO)
miconazole  (EXP)
microcystin-LR  (ISO)
monosodium L-glutamate  (EXP)
N-nitrosodiethylamine  (ISO)
niclosamide  (ISO)
notoginsenoside R1  (ISO)
ochratoxin A  (ISO)
ouabain  (ISO)
paclitaxel  (ISO)
pamidronate  (ISO)
paracetamol  (EXP)
paraquat  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
propiconazole  (EXP)
pyridaben  (EXP)
pyrimidifen  (ISO)
quercetin  (ISO)
quercitrin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (ISO)
sorafenib  (ISO)
streptozocin  (ISO)
succimer  (EXP)
testosterone  (ISO)
thapsigargin  (ISO)
tipifarnib  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
Triptolide  (EXP,ISO)
troglitazone  (ISO)
tungsten  (EXP)
valproic acid  (ISO)
Y-27632  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IGI)
actomyosin structure organization  (IBA)
aortic valve morphogenesis  (ISO)
apical constriction  (IGI)
apoptotic process  (IEA)
bleb assembly  (IMP)
blood vessel diameter maintenance  (IMP)
cellular response to transforming growth factor beta stimulus  (ISO)
cortical actin cytoskeleton organization  (IBA,ISO)
cytoskeleton organization  (ISO)
embryonic morphogenesis  (IBA)
epithelial to mesenchymal transition  (IGI)
I-kappaB kinase/NF-kappaB signaling  (ISO)
leukocyte cell-cell adhesion  (ISO)
leukocyte migration  (ISO)
leukocyte tethering or rolling  (ISO)
membrane to membrane docking  (ISO)
mitotic cytokinesis  (IBA)
motor neuron apoptotic process  (IMP)
mRNA destabilization  (IMP)
myoblast migration  (IMP)
negative regulation of amyloid precursor protein catabolic process  (ISO)
negative regulation of amyloid-beta formation  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of bicellular tight junction assembly  (ISO)
negative regulation of biomineral tissue development  (ISO)
negative regulation of motor neuron apoptotic process  (IMP)
negative regulation of myosin-light-chain-phosphatase activity  (ISO)
negative regulation of phosphorylation  (IMP)
negative regulation of protein binding  (ISO)
neuron projection arborization  (ISO)
neuron projection development  (ISO)
peptidyl-serine phosphorylation  (ISO)
peptidyl-threonine phosphorylation  (IBA)
phosphorylation  (IEA)
podocyte cell migration  (IMP)
positive regulation of amyloid-beta clearance  (ISO)
positive regulation of autophagy  (ISO)
positive regulation of cardiac muscle hypertrophy  (ISO)
positive regulation of connective tissue replacement  (ISO)
positive regulation of dephosphorylation  (ISO)
positive regulation of focal adhesion assembly  (IMP)
positive regulation of gene expression  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of phosphatase activity  (ISO)
positive regulation of protein localization to nucleus  (ISO)
protein localization to plasma membrane  (ISO)
protein phosphorylation  (ISO)
regulation of actin cytoskeleton organization  (IMP,ISO)
regulation of actin filament-based process  (IGI)
regulation of angiotensin-activated signaling pathway  (ISO)
regulation of cell junction assembly  (IBA)
regulation of cell migration  (ISO)
regulation of establishment of endothelial barrier  (ISO)
regulation of keratinocyte differentiation  (ISO)
regulation of microtubule cytoskeleton organization  (ISO)
regulation of neuron differentiation  (ISO)
regulation of synapse maturation  (IDA,IMP)
regulation of synaptic vesicle endocytosis  (ISO)
response to angiotensin  (IGI)
response to transforming growth factor beta  (IGI,ISO)
Rho protein signal transduction  (IBA,ISO)
signal transduction  (IEA)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal autophagy  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal eyelid morphology  (IAGP)
abnormal keratinocyte morphology  (IAGP)
abnormal leukocyte adhesion  (IAGP)
abnormal leukocyte migration  (IAGP)
abnormal mitochondrial physiology  (IAGP)
abnormal nervous system electrophysiology  (IAGP)
abnormal respiratory system physiology  (IAGP)
abnormal vascular endothelial cell physiology  (IAGP)
abnormal vascular smooth muscle morphology  (IAGP)
abnormal vascular wound healing  (IAGP)
albuminuria  (IAGP)
blepharitis  (IAGP)
decreased locomotor activity  (IAGP)
edema  (IEA)
embryonic lethality at implantation, incomplete penetrance  (IAGP)
enlarged kidney  (IAGP)
expanded mesangial matrix  (IAGP)
eyelids open at birth  (IAGP)
hyperglycemia  (IAGP)
impaired macrophage chemotaxis  (IAGP)
impaired neutrophil recruitment  (IAGP)
increased body size  (IAGP)
increased body weight  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating leptin level  (IAGP)
increased epididymal fat pad weight  (IAGP)
increased food intake  (IAGP)
increased heart rate  (IAGP)
increased kidney weight  (IAGP)
increased mesenteric fat pad weight  (IAGP)
increased renal fat pad weight  (IAGP)
increased renal glomerulus apoptosis  (IAGP)
increased renal glomerulus basement membrane thickness  (IAGP)
increased total body fat amount  (IAGP)
insulin resistance  (IAGP)
lethality, incomplete penetrance  (IAGP)
obese  (IAGP)
ocular hypotension  (IAGP)
omphalocele  (IAGP)
oxidative stress  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
preweaning lethality, incomplete penetrance  (IEA)
References

References - curated
# Reference Title Reference Citation
1. Re-expression of proteins involved in cytokinesis during cardiac hypertrophy. Ahuja P, etal., Exp Cell Res. 2007 Apr 1;313(6):1270-83. Epub 2007 Jan 27.
2. Defective neurogenesis in citron kinase knockout mice by altered cytokinesis and massive apoptosis. Di Cunto F, etal., Neuron 2000 Oct;28(1):115-27.
3. The rho/rho-kinase pathway is involved in the progression of testicular germ cell tumour. Kamai T, etal., BJU Int. 2002 Mar;89(4):449-53.
4. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
5. Ginkgolic acid (GA) suppresses gastric cancer growth by inducing apoptosis and suppressing STAT3/JAK2 signaling regulated by ROS. Liang JR and Yang H, Biomed Pharmacother. 2020 May;125:109585. doi: 10.1016/j.biopha.2019.109585. Epub 2020 Feb 25.
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. MGD IEA MGD IEA
8. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11. Mouse MP Annotation Import Pipeline RGD automated import pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8772201   PMID:9247125   PMID:9535835   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11532918   PMID:11544199   PMID:12021256   PMID:12477932   PMID:12508221  
PMID:12588996   PMID:12773565   PMID:12832488   PMID:12897243   PMID:12904583   PMID:14559914   PMID:14610273   PMID:14657354   PMID:14726536   PMID:14962675   PMID:15071095   PMID:15096457  
PMID:15151987   PMID:15322110   PMID:15464581   PMID:15489334   PMID:15601830   PMID:15637299   PMID:15665004   PMID:15753128   PMID:15775972   PMID:15845872   PMID:15956119   PMID:16098146  
PMID:16098829   PMID:16107646   PMID:16141072   PMID:16141073   PMID:16141422   PMID:16249236   PMID:16260611   PMID:16260635   PMID:16574652   PMID:16613852   PMID:16675849   PMID:16705174  
PMID:16741948   PMID:16862148   PMID:16983089   PMID:17005937   PMID:17135244   PMID:17229766   PMID:17299801   PMID:17347801   PMID:17524389   PMID:17606625   PMID:17606864   PMID:17654484  
PMID:17681946   PMID:17875933   PMID:17928439   PMID:18084615   PMID:18178218   PMID:18332105   PMID:18339671   PMID:18414683   PMID:18477564   PMID:18556458   PMID:18695640   PMID:18714354  
PMID:18723680   PMID:18799693   PMID:18829867   PMID:18946488   PMID:19014928   PMID:19036714   PMID:19106222   PMID:19113908   PMID:19181962   PMID:19201893   PMID:19265163   PMID:19276091  
PMID:19286943   PMID:19406912   PMID:19456252   PMID:19666843   PMID:19755789   PMID:19801895   PMID:19808661   PMID:19923274   PMID:20004716   PMID:20008297   PMID:20086008   PMID:20133903  
PMID:20169147   PMID:20435688   PMID:20558775   PMID:20593289   PMID:20605790   PMID:20709073   PMID:21177343   PMID:21267068   PMID:21327982   PMID:21451048   PMID:21471517   PMID:21493898  
PMID:21558549   PMID:21565918   PMID:21576392   PMID:21685893   PMID:21732490   PMID:21747168   PMID:21792909   PMID:21873635   PMID:21895889   PMID:21903164   PMID:21907926   PMID:22088464  
PMID:22100295   PMID:22140430   PMID:22186730   PMID:22205227   PMID:22244698   PMID:22278938   PMID:22326220   PMID:22355071   PMID:22389400   PMID:22433673   PMID:22465314   PMID:22547064  
PMID:22629443   PMID:22794259   PMID:22798675   PMID:22798677   PMID:22863010   PMID:22889758   PMID:22934846   PMID:22941110   PMID:22986902   PMID:23066013   PMID:23139861   PMID:23169653  
PMID:23250919   PMID:23271052   PMID:23327740   PMID:23392171   PMID:23562267   PMID:23566117   PMID:23598717   PMID:23707981   PMID:23723064   PMID:23877263   PMID:23885017   PMID:23946538  
PMID:24240172   PMID:24244596   PMID:24289040   PMID:24326423   PMID:24358370   PMID:24378336   PMID:24429217   PMID:24562870   PMID:24595357   PMID:24637663   PMID:24638037   PMID:24825879  
PMID:25129107   PMID:25596276   PMID:25703008   PMID:25704819   PMID:25774552   PMID:25857352   PMID:25908026   PMID:25934709   PMID:26040287   PMID:26054539   PMID:26134406   PMID:26276827  
PMID:26335717   PMID:26481340   PMID:26496610   PMID:26658190   PMID:26765561   PMID:26842599   PMID:26875770   PMID:26881253   PMID:26915982   PMID:26943578   PMID:27221467   PMID:27246255  
PMID:27411515   PMID:27430620   PMID:27575935   PMID:27619816   PMID:27626380   PMID:27633771   PMID:27780848   PMID:27791202   PMID:27880913   PMID:27886408   PMID:28323616   PMID:28477140  
PMID:28650466   PMID:28671696   PMID:28678840   PMID:28679962   PMID:28751650   PMID:28923399   PMID:29044117   PMID:29115372   PMID:29211497   PMID:29353861   PMID:29428217   PMID:29560126  
PMID:29654945   PMID:29800294   PMID:29987023   PMID:30115939   PMID:30120419   PMID:30194990   PMID:30196430   PMID:30226474   PMID:30228103   PMID:30811958   PMID:30826947   PMID:30848941  
PMID:31182644   PMID:31228531   PMID:31262973   PMID:31302146   PMID:31387911   PMID:31578315   PMID:31638192   PMID:31647781   PMID:31914704   PMID:32070020   PMID:32141548   PMID:32325033  
PMID:32507765   PMID:32511952   PMID:32554809   PMID:32725958   PMID:33297931   PMID:33525555   PMID:33871359   PMID:34050187   PMID:34058434   PMID:34274973   PMID:34365196   PMID:34555357  
PMID:34774989   PMID:34988124   PMID:35265203   PMID:35303680   PMID:35597365   PMID:36116511   PMID:36252478   PMID:36374631   PMID:36497425   PMID:36509022  


Genomics

Comparative Map Data
Rock1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391810,064,401 - 10,182,225 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1810,064,401 - 10,182,045 (-)EnsemblGRCm39 Ensembl
GRCm381810,064,401 - 10,182,251 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1810,064,401 - 10,182,045 (-)EnsemblGRCm38mm10GRCm38
MGSCv371810,064,399 - 10,181,790 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361810,067,465 - 10,181,315 (-)NCBIMGSCv36mm8
Celera1810,094,528 - 10,211,725 (-)NCBICelera
Cytogenetic Map18A1NCBI
ROCK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381820,946,906 - 21,111,813 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1820,946,906 - 21,111,813 (-)EnsemblGRCh38hg38GRCh38
GRCh371818,526,867 - 18,691,774 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361816,783,699 - 16,945,810 (-)NCBINCBI36Build 36hg18NCBI36
Build 341816,787,532 - 16,944,869NCBI
Celera1815,335,539 - 15,497,459 (-)NCBICelera
Cytogenetic Map18q11.1NCBI
HuRef1815,376,598 - 15,538,887 (-)NCBIHuRef
CHM1_11818,456,721 - 18,618,879 (-)NCBICHM1_1
T2T-CHM13v2.01821,131,976 - 21,296,884 (-)NCBIT2T-CHM13v2.0
Rock1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2181,114,532 - 1,236,345 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl181,115,905 - 1,235,571 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx181,332,915 - 1,454,715 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0182,120,746 - 2,242,546 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0181,334,812 - 1,456,617 (-)NCBIRnor_WKY
Rnor_6.0181,273,490 - 1,390,790 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl181,273,453 - 1,390,190 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,316,022 - 1,433,175 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4181,391,751 - 1,511,865 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1181,391,824 - 1,511,866 (-)NCBI
Celera181,001,677 - 1,120,847 (-)NCBICelera
Cytogenetic Map18p13NCBI
Rock1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554029,750,730 - 9,864,317 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554029,752,101 - 9,864,317 (-)NCBIChiLan1.0ChiLan1.0
ROCK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11824,061,911 - 24,221,935 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01814,192,293 - 14,352,357 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11817,831,594 - 17,991,039 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1817,833,047 - 17,990,086 (-)Ensemblpanpan1.1panPan2
ROCK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1766,862,614 - 67,001,538 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl766,862,608 - 67,142,853 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha766,316,405 - 66,455,341 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0766,927,186 - 67,066,094 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl766,927,171 - 67,066,030 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1766,592,264 - 66,730,420 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0766,616,250 - 66,754,480 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0766,917,945 - 67,056,895 (+)NCBIUU_Cfam_GSD_1.0
Rock1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494462,941,517 - 63,085,618 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936550733,239 - 874,601 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936550730,462 - 874,601 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ROCK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6106,163,989 - 106,314,944 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16106,163,899 - 106,314,998 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2698,710,281 - 98,860,883 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ROCK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11859,384,822 - 59,538,780 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1859,384,944 - 59,540,070 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605034,174,637 - 34,329,252 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rock1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477010,592,304 - 10,731,640 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rock1
2771 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir335mmu-miR-335-5pOncomiRDBexternal_infoNANA22382496
Mir148ammu-miR-148a-3pMirtarbaseexternal_infoImmunofluorescence//Luciferase reporter assay//qRTFunctional MTI22547064
Mir148ammu-miR-148a-3pOncomiRDBexternal_infoNANA21994419
Mir146bmmu-miR-146b-5pOncomiRDBexternal_infoNANA18174313

Predicted Target Of
Summary Value
Count of predictions:368
Count of miRNA genes:276
Interacting mature miRNAs:304
Transcripts:ENSMUST00000067947
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142127Rafaril_mRafar interacting locus (mouse)Not determined18123108555Mouse
14928307Manh83_mmandible shape 83 (mouse)18126902168Mouse
11354953Mom21_mmodifier of Min 21 (mouse)18128893823Mouse
12801462Intim3_mintima modifier 3 (mouse)18131720756Mouse
12801458Intmrm3_mintima/media ratio modifier 3 (mouse)18131720756Mouse
13207585Mwmlpt3_mMorris water maze latency to platform, training, 3 (mouse)18133547739Mouse
13207589Mwmlpa3_mMorris water maze latency to platform, all, 3 (mouse)18133547739Mouse
27226723Tibw9_mtibia width 9, proximal, 16 week (mouse)18320000060933072Mouse
1558849W3q15_mweight 3 weeks QTL 15 (mouse)Not determined18504111961272643Mouse
4142250Idd21.3_minsulin dependent diabetes susceptibility 21.3 (mouse)Not determined18610840421646477Mouse
1558873Hrtfm7_mheart failure modifier 7 (mouse)Not determined18808696442087106Mouse

Markers in Region
UniSTS:237735  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381810,065,095 - 10,065,467UniSTSGRCm38
MGSCv371810,065,093 - 10,065,465UniSTSGRCm37
Celera1810,095,222 - 10,095,594UniSTS
Cytogenetic Map18A2UniSTS
Rock1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381313,275,312 - 13,275,604UniSTSGRCm38
MGSCv371313,367,579 - 13,367,871UniSTSGRCm37
Celera1313,101,700 - 13,101,992UniSTS
Cytogenetic Map13A1UniSTS
Cytogenetic Map18A2UniSTS
cM Map18 UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_009071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006525725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001782350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA163962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC102437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC132622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK050269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK077297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK085974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC057154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DR754490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U58512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000067947   ⟹   ENSMUSP00000069549
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1810,064,401 - 10,182,045 (-)Ensembl
GRCm38.p6 Ensembl1810,064,401 - 10,182,045 (-)Ensembl
RefSeq Acc Id: ENSMUST00000234050
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1810,096,937 - 10,098,813 (-)Ensembl
GRCm38.p6 Ensembl1810,096,937 - 10,098,813 (-)Ensembl
RefSeq Acc Id: ENSMUST00000234463
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1810,068,650 - 10,072,143 (-)Ensembl
GRCm38.p6 Ensembl1810,068,650 - 10,072,143 (-)Ensembl
RefSeq Acc Id: ENSMUST00000234610   ⟹   ENSMUSP00000157135
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1810,065,756 - 10,150,328 (-)Ensembl
GRCm38.p6 Ensembl1810,065,756 - 10,150,328 (-)Ensembl
RefSeq Acc Id: ENSMUST00000234734   ⟹   ENSMUSP00000157140
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1810,106,351 - 10,181,792 (-)Ensembl
GRCm38.p6 Ensembl1810,106,351 - 10,181,792 (-)Ensembl
RefSeq Acc Id: ENSMUST00000234926
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1810,084,369 - 10,088,208 (-)Ensembl
GRCm38.p6 Ensembl1810,084,369 - 10,088,208 (-)Ensembl
RefSeq Acc Id: ENSMUST00000235067
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1810,065,679 - 10,067,910 (-)Ensembl
GRCm38.p6 Ensembl1810,065,679 - 10,067,910 (-)Ensembl
RefSeq Acc Id: ENSMUST00000235075
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1810,109,644 - 10,112,378 (-)Ensembl
GRCm38.p6 Ensembl1810,109,644 - 10,112,378 (-)Ensembl
RefSeq Acc Id: NM_009071   ⟹   NP_033097
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391810,064,401 - 10,181,792 (-)NCBI
GRCm381810,064,401 - 10,181,792 (-)ENTREZGENE
MGSCv371810,064,399 - 10,181,790 (-)RGD
Celera1810,094,528 - 10,211,725 (-)RGD
cM Map18 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006525725   ⟹   XP_006525788
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391810,064,528 - 10,182,045 (-)NCBI
GRCm381810,064,528 - 10,182,045 (-)NCBI
Sequence:
RefSeq Acc Id: XR_001782350
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391810,064,528 - 10,182,225 (-)NCBI
GRCm381810,064,528 - 10,182,251 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_033097   ⟸   NM_009071
- UniProtKB: Q8C7H0 (UniProtKB/Swiss-Prot),   P70335 (UniProtKB/Swiss-Prot),   Q3UE22 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006525788   ⟸   XM_006525725
- Peptide Label: isoform X1
- UniProtKB: P70335 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000069549   ⟸   ENSMUST00000067947
RefSeq Acc Id: ENSMUSP00000157140   ⟸   ENSMUST00000234734
RefSeq Acc Id: ENSMUSP00000157135   ⟸   ENSMUST00000234610
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70335-F1-model_v2 AlphaFold P70335 1-1354 view protein structure

Promoters
RGD ID:6829509
Promoter ID:MM_KWN:24569
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000067947,   NM_009071,   UC008EAR.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361810,181,436 - 10,182,517 (-)MPROMDB
RGD ID:13677084
Promoter ID:EPDNEW_M22691
Type:multiple initiation site
Name:Rock1_1
Description:Mus musculus Rho-associated coiled-coil containing protein kinase1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381810,181,766 - 10,181,826EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107927 AgrOrtholog
Ensembl Genes ENSMUSG00000024290 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000069549 ENTREZGENE
  ENSMUSP00000069549.6 UniProtKB/Swiss-Prot
  ENSMUSP00000157135.2 UniProtKB/TrEMBL
  ENSMUSP00000157140.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000067947 ENTREZGENE
  ENSMUST00000067947.7 UniProtKB/Swiss-Prot
  ENSMUST00000234610.2 UniProtKB/TrEMBL
  ENSMUST00000234734.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.340 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.60.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Single helix bin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C1-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HR1_rho-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PE/DAG-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rho-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ROCK1/ROCK2 UniProtKB/Swiss-Prot
  ROCK1_HR1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:19877 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:107927 ENTREZGENE
NCBI Gene 19877 ENTREZGENE
PANTHER MYOTONIC DYSTROPHY S/T KINASE-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHO-ASSOCIATED PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHO-ASSOCIATED PROTEIN KINASE 1 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rho_Binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rock1 PhenoGen
PIRSF Integrin-linked_kinase UniProtKB/TrEMBL
  Rho_kinase UniProtKB/Swiss-Prot
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  REM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHO_BD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TK_X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00109 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP G protein-binding domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin rod fragments UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57889 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A3Q4EGR2_MOUSE UniProtKB/TrEMBL
  A0A3Q4L2X0_MOUSE UniProtKB/TrEMBL
  P70335 ENTREZGENE
  Q3TBE0_MOUSE UniProtKB/TrEMBL
  Q3UE22 ENTREZGENE, UniProtKB/TrEMBL
  Q8C7H0 ENTREZGENE
  ROCK1_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q8C3G4 UniProtKB/Swiss-Prot
  Q8C7H0 UniProtKB/Swiss-Prot