Nlgn3 (neuroligin 3) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Nlgn3 (neuroligin 3) Mus musculus
Analyze
Symbol: Nlgn3
Name: neuroligin 3
RGD ID: 733572
MGI Page MGI
Description: Predicted to enable several functions, including cell adhesion molecule binding activity; neurexin family protein binding activity; and scaffold protein binding activity. Involved in several processes, including chemical postsynaptic transmission; modulation of chemical synaptic transmission; and regulation of synapse organization. Acts upstream of or within several processes, including oligodendrocyte differentiation; regulation of respiratory gaseous exchange by nervous system process; and visual learning. Predicted to be located in several cellular components, including excitatory synapse; inhibitory synapse; and postsynaptic membrane. Predicted to be active in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and postsynaptic specialization membrane. Is expressed in several structures, including central nervous system; eye; and heart. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human NLGN3 (neuroligin 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A230085M13Rik; gliotactin homolog; HN; HNL3; N; neuroligin 3 protein; neuroligin-3; NL; NL3; NLG3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X100,342,785 - 100,364,956 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX100,342,774 - 100,369,569 (+)EnsemblGRCm39 Ensembl
GRCm38X101,299,179 - 101,321,350 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX101,299,168 - 101,325,963 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X98,494,520 - 98,516,689 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X97,501,929 - 97,524,067 (+)NCBIMGSCv36mm8
CeleraX88,215,228 - 88,237,795 (+)NCBICelera
Cytogenetic MapXDNCBI
cM MapX43.95NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult behavior  (ISO)
axon extension  (ISO,ISS)
chemical synaptic transmission  (IBA)
circadian sleep/wake cycle  (ISO)
excitatory postsynaptic potential  (IMP)
inhibitory postsynaptic potential  (IMP,ISO)
learning  (ISO)
long-term synaptic potentiation  (IMP)
modulation of chemical synaptic transmission  (IBA,IGI)
negative regulation of dendritic spine morphogenesis  (IMP)
negative regulation of excitatory postsynaptic potential  (IMP)
neuron cell-cell adhesion  (IBA,ISO,ISS)
oligodendrocyte differentiation  (IMP)
positive regulation of AMPA receptor activity  (IMP)
positive regulation of dendritic spine development  (ISO)
positive regulation of excitatory postsynaptic potential  (IMP)
positive regulation of glutamate receptor signaling pathway  (IMP)
positive regulation of inhibitory postsynaptic potential  (ISO)
positive regulation of protein localization to synapse  (ISO)
positive regulation of synapse assembly  (IMP,ISO,ISS)
positive regulation of synaptic transmission, glutamatergic  (IMP)
positive regulation of synaptic vesicle clustering  (IMP)
postsynaptic membrane assembly  (IBA,IMP)
postsynaptic specialization assembly  (ISO)
prepulse inhibition  (ISO)
presynaptic membrane assembly  (IBA,ISO,ISS)
receptor-mediated endocytosis  (ISO,ISS)
regulation of AMPA receptor activity  (IMP)
regulation of dendritic spine morphogenesis  (IMP)
regulation of long-term synaptic potentiation  (IMP)
regulation of NMDA receptor activity  (IMP)
regulation of respiratory gaseous exchange by nervous system process  (IGI)
regulation of synaptic transmission, glutamatergic  (IMP)
regulation of terminal button organization  (IMP)
rhythmic synaptic transmission  (ISO,ISS)
social behavior  (IMP,ISO)
synapse assembly  (ISO)
synapse organization  (IGI,ISO)
synaptic vesicle endocytosis  (IBA)
visual learning  (IMP)
vocalization behavior  (ISO)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal blood uric acid level  (IEA)
abnormal CNS synaptic transmission  (IAGP)
abnormal excitatory postsynaptic potential  (IAGP)
abnormal glutamate-mediated receptor currents  (IAGP)
abnormal inhibitory postsynaptic currents  (IAGP)
abnormal learning/memory/conditioning  (IAGP)
abnormal locomotor activation  (IEA)
abnormal miniature excitatory postsynaptic currents  (IAGP)
abnormal miniature inhibitory postsynaptic currents  (IAGP)
abnormal motor coordination/balance  (IAGP)
abnormal nervous system development  (IAGP)
abnormal parental behavior  (IAGP)
abnormal pre-Botzinger complex physiology  (IAGP)
abnormal respiration  (IAGP)
abnormal righting response  (IAGP)
abnormal social investigation  (IAGP)
abnormal spatial learning  (IAGP)
abnormal synapse morphology  (IAGP)
abnormal synaptic bouton morphology  (IAGP)
absent long-term depression  (IAGP)
decreased anxiety-related response  (IEA)
decreased body weight  (IAGP)
decreased brain size  (IAGP)
decreased excitatory postsynaptic current amplitude  (IAGP)
decreased locomotor activity  (IAGP)
decreased miniature inhibitory postsynaptic current amplitude  (IAGP)
decreased miniature inhibitory postsynaptic current frequency  (IAGP)
decreased startle reflex  (IAGP)
decreased vertical activity  (IAGP)
decreased vocalization  (IAGP)
enhanced coordination  (IAGP)
enhanced learning  (IAGP)
hyperactivity  (IAGP)
impaired contextual conditioning behavior  (IAGP)
impaired coordination  (IAGP)
impaired cued conditioning behavior  (IAGP)
impaired olfaction  (IAGP)
impaired synaptic plasticity  (IAGP)
increased bone mineral density  (IEA)
increased CNS synapse formation  (IAGP)
increased eosinophil cell number  (IEA)
increased excitatory postsynaptic current amplitude  (IAGP)
increased exploration in new environment  (IAGP)
increased growth rate  (IAGP)
increased locomotor activity  (IAGP)
increased stereotypic behavior  (IAGP)
increased thigmotaxis  (IAGP)
increased vertical activity  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
postnatal growth retardation  (IAGP)
reduced AMPA-mediated synaptic currents  (IAGP)
reduced fertility  (IAGP)
stereotypic behavior  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Fmr1 and Nlgn3 knockout rats: novel tools for investigating autism spectrum disorders. Hamilton SM, etal., Behav Neurosci. 2014 Apr;128(2):103-9. doi: 10.1037/a0035988.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Transcellular neuroligin-2 interactions enhance insulin secretion and are integral to pancreatic beta cell function. Suckow AT, etal., J Biol Chem. 2012 Jun 8;287(24):19816-26. doi: 10.1074/jbc.M111.280537. Epub 2012 Apr 23.
10. Sleep/Wake Physiology and Quantitative Electroencephalogram Analysis of the Neuroligin-3 Knockout Rat Model of Autism Spectrum Disorder. Thomas AM, etal., Sleep. 2017 Oct 1;40(10). pii: 4100612. doi: 10.1093/sleep/zsx138.
11. Down-regulation of mRNAs for synaptic adhesion molecules neuroligin-2 and -3 and synCAM1 in spinal motoneurons after axotomy. Zelano J, etal., J Comp Neurol. 2007 Jul 10;503(2):308-18.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11329178   PMID:11544199   PMID:12477932   PMID:14610273   PMID:15368895   PMID:15681343   PMID:16141072  
PMID:16141073   PMID:16186258   PMID:16602821   PMID:16982420   PMID:17540781   PMID:17823315   PMID:17897391   PMID:18227507   PMID:18799693   PMID:18854036   PMID:19139271   PMID:19243448  
PMID:19360662   PMID:19406211   PMID:19607885   PMID:20163789   PMID:20579107   PMID:20630950   PMID:21267068   PMID:21642956   PMID:21677750   PMID:21788371   PMID:21808020   PMID:21873635  
PMID:22633921   PMID:22671294   PMID:22768092   PMID:22983708   PMID:23010509   PMID:23226954   PMID:23583622   PMID:24046374   PMID:24151012   PMID:24619977   PMID:24995986   PMID:25144834  
PMID:25299583   PMID:25347860   PMID:25592157   PMID:25693924   PMID:25778475   PMID:26291161   PMID:26403076   PMID:26469287   PMID:27050589   PMID:27080031   PMID:27217145   PMID:27452274  
PMID:27507650   PMID:27581450   PMID:27725662   PMID:28067903   PMID:28255463   PMID:28385162   PMID:28607166   PMID:28671696   PMID:28706196   PMID:28708891   PMID:28795135   PMID:28864826  
PMID:28921757   PMID:28939043   PMID:28959975   PMID:29100073   PMID:29254152   PMID:29503190   PMID:29724786   PMID:29742426   PMID:30056576   PMID:30093665   PMID:30123111   PMID:30201312  
PMID:30664619   PMID:30871858   PMID:31379628   PMID:31827744   PMID:32011705   PMID:32325033   PMID:32327975   PMID:32381505   PMID:32581705   PMID:32669345   PMID:32719346   PMID:32760004  
PMID:32879325   PMID:32973045   PMID:33335150   PMID:33347690   PMID:33355091   PMID:33758193   PMID:34040258   PMID:34085373   PMID:34262438   PMID:34321999   PMID:34616037   PMID:34715405  
PMID:34845591   PMID:34848499   PMID:34919427   PMID:35704570   PMID:35992071   PMID:36280753   PMID:36476879   PMID:36582822   PMID:36810932   PMID:37142655   PMID:37196079   PMID:37509099  
PMID:37542090   PMID:37699715   PMID:37865312   PMID:37880221   PMID:38047770   PMID:38272450   PMID:38355793   PMID:38459194   PMID:39058792  


Genomics

Comparative Map Data
Nlgn3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X100,342,785 - 100,364,956 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX100,342,774 - 100,369,569 (+)EnsemblGRCm39 Ensembl
GRCm38X101,299,179 - 101,321,350 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX101,299,168 - 101,325,963 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X98,494,520 - 98,516,689 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X97,501,929 - 97,524,067 (+)NCBIMGSCv36mm8
CeleraX88,215,228 - 88,237,795 (+)NCBICelera
Cytogenetic MapXDNCBI
cM MapX43.95NCBI
NLGN3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X71,144,841 - 71,175,307 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX71,144,821 - 71,175,255 (+)EnsemblGRCh38hg38GRCh38
GRCh37X70,364,691 - 70,391,051 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X70,281,436 - 70,307,776 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X70,147,731 - 70,174,070NCBI
CeleraX70,718,556 - 70,744,930 (+)NCBICelera
Cytogenetic MapXq13.1NCBI
HuRefX64,183,444 - 64,209,758 (+)NCBIHuRef
CHM1_1X70,257,401 - 70,284,066 (+)NCBICHM1_1
T2T-CHM13v2.0X69,578,926 - 69,609,395 (+)NCBIT2T-CHM13v2.0
Nlgn3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X70,469,251 - 70,497,380 (+)NCBIGRCr8
mRatBN7.2X66,427,926 - 66,457,378 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX66,429,458 - 66,451,876 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX67,912,829 - 67,935,228 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X71,413,217 - 71,435,616 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X68,974,124 - 68,996,518 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X71,199,390 - 71,227,460 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX71,199,491 - 71,222,732 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X72,051,846 - 72,075,119 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X89,376,193 - 89,398,665 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X89,449,625 - 89,471,949 (+)NCBI
CeleraX66,785,377 - 66,807,774 (+)NCBICelera
Cytogenetic MapXq22NCBI
Nlgn3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547510,712,170 - 10,735,857 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547510,712,170 - 10,735,857 (+)NCBIChiLan1.0ChiLan1.0
NLGN3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X70,822,214 - 70,848,479 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X70,825,828 - 70,852,082 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X60,413,098 - 60,439,359 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X70,469,764 - 70,496,526 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX70,469,764 - 70,496,526 (+)Ensemblpanpan1.1panPan2
NLGN3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X55,510,729 - 55,532,396 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX55,513,626 - 55,531,371 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX46,337,800 - 46,359,510 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X56,479,897 - 56,501,589 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX56,479,918 - 56,501,589 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X54,447,828 - 54,469,515 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X55,779,249 - 55,800,946 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X55,706,411 - 55,728,100 (+)NCBIUU_Cfam_GSD_1.0
Nlgn3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X46,672,077 - 46,696,110 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936762435,729 - 458,423 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936762435,729 - 458,261 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NLGN3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX57,176,103 - 57,201,461 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X57,174,506 - 57,204,770 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X64,705,492 - 64,727,915 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NLGN3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X60,941,371 - 60,967,942 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX60,941,654 - 60,967,936 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660652,802,397 - 2,828,656 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nlgn3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249031,438,428 - 1,463,172 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249031,437,663 - 1,465,955 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nlgn3
411 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:9213
Count of miRNA genes:1016
Interacting mature miRNAs:1530
Transcripts:ENSMUST00000065858, ENSMUST00000118111, ENSMUST00000130555, ENSMUST00000144860, ENSMUST00000147443, ENSMUST00000151528
Prediction methods:Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141630Gct6_mgranulosa cell tumorigenesis 6 (mouse)Not determined47179121129764756Mouse
13208552Wght12_mweight 12 (mouse)X94043606149782996Mouse
4141803Lmr30_mleishmaniasis resistance 30 (mouse)Not determined85062606119062720Mouse
1302054Gct4_mgranulosa cell tumorigenesis 4 (mouse)Not determinedX76124336102062720Mouse
13208556Lgth14_mbody length 14 (mouse)X94043606149782996Mouse
13824980Ferq1_mgenetic fertility QTL 1 (mouse)X54045360148782996Mouse
11075102Modc2_mmodifier of Odc2 (mouse)X80189914114190059Mouse
1357500Mdmsc6_mmodifier of muscularity 6 (mouse)Not determinedX75306671109306758Mouse
12879918Shm4_msperm head morphology 4 (mouse)X72072050102062720Mouse
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse
4141665Mhysq2_mmale hybrid sterility QTL 2 (mouse)Not determined71453852139203212Mouse

Markers in Region
RH79662  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X101,297,218 - 101,297,400UniSTSGRCm38
MGSCv37X98,492,557 - 98,492,739UniSTSGRCm37
CeleraX88,213,265 - 88,213,447UniSTS
Cytogenetic MapXDUniSTS
Cytogenetic MapXC2UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000065858   ⟹   ENSMUSP00000066304
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX100,342,816 - 100,369,569 (+)Ensembl
GRCm38.p6 EnsemblX101,299,210 - 101,325,963 (+)Ensembl
Ensembl Acc Id: ENSMUST00000118111   ⟹   ENSMUSP00000113863
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX100,342,774 - 100,369,569 (+)Ensembl
GRCm38.p6 EnsemblX101,299,168 - 101,325,963 (+)Ensembl
Ensembl Acc Id: ENSMUST00000130555   ⟹   ENSMUSP00000122213
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX100,342,781 - 100,362,281 (+)Ensembl
GRCm38.p6 EnsemblX101,299,175 - 101,318,675 (+)Ensembl
Ensembl Acc Id: ENSMUST00000144860
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX100,357,997 - 100,361,757 (+)Ensembl
GRCm38.p6 EnsemblX101,314,391 - 101,318,151 (+)Ensembl
Ensembl Acc Id: ENSMUST00000147443
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX100,344,080 - 100,345,660 (+)Ensembl
GRCm38.p6 EnsemblX101,300,474 - 101,302,054 (+)Ensembl
Ensembl Acc Id: ENSMUST00000151528   ⟹   ENSMUSP00000123283
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX100,342,800 - 100,369,569 (+)Ensembl
GRCm38.p6 EnsemblX101,299,194 - 101,325,963 (+)Ensembl
RefSeq Acc Id: NM_172932   ⟹   NP_766520
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X100,342,785 - 100,364,956 (+)NCBI
GRCm38X101,299,179 - 101,321,350 (+)ENTREZGENE
MGSCv37X98,494,520 - 98,516,689 (+)RGD
CeleraX88,215,226 - 88,237,795 (+)ENTREZGENE
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NP_766520   ⟸   NM_172932
- Peptide Label: precursor
- UniProtKB: A2AGI1 (UniProtKB/Swiss-Prot),   Q8BXR4 (UniProtKB/Swiss-Prot),   Q8BYM5 (UniProtKB/Swiss-Prot),   A0A5S9EF37 (UniProtKB/TrEMBL),   A0A5S9EER5 (UniProtKB/TrEMBL),   A0A5S9EES2 (UniProtKB/TrEMBL),   B2RWZ9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000122213   ⟸   ENSMUST00000130555
Ensembl Acc Id: ENSMUSP00000066304   ⟸   ENSMUST00000065858
Ensembl Acc Id: ENSMUSP00000113863   ⟸   ENSMUST00000118111
Ensembl Acc Id: ENSMUSP00000123283   ⟸   ENSMUST00000151528
Protein Domains
Carboxylesterase type B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BYM5-F1-model_v2 AlphaFold Q8BYM5 1-825 view protein structure

Promoters
RGD ID:6846030
Promoter ID:MM_KWN:61313
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour
Transcripts:UC009TXI.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X98,489,716 - 98,490,216 (+)MPROMDB
RGD ID:6846031
Promoter ID:MM_KWN:61314
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Liver,   Spleen
Transcripts:OTTMUST00000043943,   OTTMUST00000043998
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X98,490,506 - 98,491,947 (+)MPROMDB
RGD ID:6846026
Promoter ID:MM_KWN:61315
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Lung,   MEF_B6,   Spleen
Transcripts:ENSMUST00000118111,   OTTMUST00000043939,   OTTMUST00000043941,   OTTMUST00000043942
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X98,493,841 - 98,494,617 (+)MPROMDB
RGD ID:6846028
Promoter ID:MM_KWN:61316
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour,   Brain
Transcripts:OTTMUST00000043944
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X98,495,266 - 98,496,032 (+)MPROMDB
RGD ID:6846029
Promoter ID:MM_KWN:61317
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000043945
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X98,509,231 - 98,509,731 (+)MPROMDB
RGD ID:13681070
Promoter ID:EPDNEW_M24684
Type:initiation region
Name:Nlgn3_1
Description:Mus musculus neuroligin 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X101,299,179 - 101,299,239EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2444609 AgrOrtholog
Ensembl Genes ENSMUSG00000031302 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000065858 ENTREZGENE
  ENSMUST00000065858.3 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot
InterPro AB_hydrolase UniProtKB/Swiss-Prot
  CarbesteraseB UniProtKB/Swiss-Prot
  Carboxylesterase_B_CS UniProtKB/Swiss-Prot
  Neuroligin/BSAL UniProtKB/Swiss-Prot
  Nlgn UniProtKB/Swiss-Prot
KEGG Report mmu:245537 UniProtKB/Swiss-Prot
MGD MGI:2444609 ENTREZGENE
NCBI Gene 245537 ENTREZGENE
PANTHER NEUROLIGIN UniProtKB/Swiss-Prot
Pfam COesterase UniProtKB/Swiss-Prot
PhenoGen Nlgn3 PhenoGen
PRINTS NEUROLIGIN UniProtKB/Swiss-Prot
PROSITE CARBOXYLESTERASE_B_2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot
UniProt A0A5S9EER5 ENTREZGENE, UniProtKB/TrEMBL
  A0A5S9EES2 ENTREZGENE, UniProtKB/TrEMBL
  A0A5S9EF37 ENTREZGENE
  A2AGI0_MOUSE UniProtKB/TrEMBL
  A2AGI1 ENTREZGENE
  A2AGI2_MOUSE UniProtKB/TrEMBL
  A2AGI3_MOUSE UniProtKB/TrEMBL
  B2RWZ9 ENTREZGENE, UniProtKB/TrEMBL
  NLGN3_MOUSE UniProtKB/Swiss-Prot
  Q8BXR4 ENTREZGENE
  Q8BYM5 ENTREZGENE
  Q924X0_MOUSE UniProtKB/TrEMBL
UniProt Secondary A2AGI1 UniProtKB/Swiss-Prot
  Q8BXR4 UniProtKB/Swiss-Prot