Psen2 (presenilin 2) - Rat Genome Database

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Gene: Psen2 (presenilin 2) Mus musculus
Analyze
Symbol: Psen2
Name: presenilin 2
RGD ID: 733570
MGI Page MGI
Description: Enables aspartic endopeptidase activity, intramembrane cleaving. Involved in several processes, including protein catabolic process at postsynapse; regulation of macromolecule metabolic process; and skin morphogenesis. Acts upstream of or within several processes, including nervous system development; regulation of apoptotic signaling pathway; and regulation of protein phosphorylation. Located in several cellular components, including Z disc; ciliary basal body; and neuronal cell body. Part of gamma-secretase complex. Is active in glutamatergic synapse. Is expressed in central nervous system; late tubule; and sensory organ. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; Alzheimer's disease 4; breast cancer; and dilated cardiomyopathy 1V. Orthologous to human PSEN2 (presenilin 2).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: Ad4; Ad4h; AI266870; ALG; ALG-3; Alg3; P; presenilin-2; PS; PS-2; PS2; Psnl2; STM2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391180,054,569 - 180,091,030 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1180,054,569 - 180,091,003 (-)EnsemblGRCm39 Ensembl
GRCm381180,227,004 - 180,263,467 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1180,227,004 - 180,263,438 (-)EnsemblGRCm38mm10GRCm38
MGSCv371182,157,135 - 182,186,431 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361182,063,681 - 182,082,576 (-)NCBIMGSCv36mm8
Celera1187,291,668 - 187,320,266 (-)NCBICelera
Cytogenetic Map1H4NCBI
cM Map184.19NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(S)-naringenin  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (ISO)
2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
4-hydroxyphenyl retinamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (EXP)
aldrin  (EXP)
aminoguanidine  (ISO)
ammonium chloride  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
calcium dichloride  (ISO)
cannabidiol  (ISO)
carbon nanotube  (EXP)
chlorpyrifos  (EXP)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (EXP)
coumarin  (ISO)
crocidolite asbestos  (EXP)
cycloheximide  (ISO)
D-glucose  (EXP)
deguelin  (ISO)
dibutyl phthalate  (ISO)
diethyldithiocarbamic acid  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
enzalutamide  (ISO)
epoxiconazole  (EXP)
flutamide  (ISO)
FR900359  (ISO)
fucoxanthin  (EXP)
genistein  (ISO)
gentamycin  (ISO)
glucose  (EXP)
glyphosate  (ISO)
lipopolysaccharide  (EXP,ISO)
methoxychlor  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
niclosamide  (ISO)
nimesulide  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
parathion  (EXP)
picoxystrobin  (ISO)
pifithrin-alpha hydrobromide  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
prostaglandin E2  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
retinyl acetate  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sarin  (ISO)
scopolamine  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenate  (ISO)
sodium azide  (ISO)
staurosporine  (ISO)
taurine  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thiram  (ISO)
titanium dioxide  (EXP)
triphenyl phosphate  (ISO)
triptonide  (EXP)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid precursor protein catabolic process  (IEA,ISO)
amyloid-beta formation  (IBA,ISO)
amyloid-beta metabolic process  (IDA,IMP)
apoptotic signaling pathway  (IGI)
brain morphogenesis  (IGI)
calcium ion homeostasis  (IBA)
calcium ion transport  (IPI)
cardiac muscle contraction  (IMP)
cell fate specification  (IGI)
dorsal/ventral neural tube patterning  (IGI)
embryonic limb morphogenesis  (IGI)
endoplasmic reticulum calcium ion homeostasis  (IGI)
forebrain development  (IGI)
hair follicle development  (IGI)
hematopoietic progenitor cell differentiation  (IGI)
intracellular signal transduction  (IEA)
learning or memory  (IGI)
locomotion  (IGI)
lung alveolus development  (IMP)
membrane protein ectodomain proteolysis  (IBA,ISO,ISS)
memory  (IGI)
mitochondrion-endoplasmic reticulum membrane tethering  (ISO,ISS)
myeloid leukocyte differentiation  (IGI)
negative regulation of apoptotic signaling pathway  (IGI)
negative regulation of epidermal growth factor-activated receptor activity  (IMP)
negative regulation of protein phosphorylation  (IGI)
negative regulation of transcription by RNA polymerase II  (IMP)
negative regulation of ubiquitin-dependent protein catabolic process  (IMP)
negative regulation of ubiquitin-protein transferase activity  (IMP)
neuroinflammatory response  (IGI,IMP)
neuron cellular homeostasis  (IGI)
Notch signaling pathway  (IBA,IGI)
positive regulation of apoptotic process  (IGI)
positive regulation of coagulation  (IMP)
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IDA)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IMP)
positive regulation of receptor recycling  (IMP)
protein catabolic process at postsynapse  (IDA,IEP,IMP)
protein maturation  (IGI)
protein processing  (IBA,IGI,ISO,ISS)
protein transport  (IGI)
regulation of calcium import into the mitochondrion  (ISO,ISS)
regulation of epidermal growth factor-activated receptor activity  (IGI)
regulation of postsynapse organization  (IDA,IEP,IMP)
regulation of synaptic plasticity  (IGI)
response to hypoxia  (ISO)
skin morphogenesis  (IMP)
somitogenesis  (IGI)
T cell activation involved in immune response  (IGI)
T cell receptor signaling pathway  (IGI)
thymus development  (IGI)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal apoptosis  (IAGP)
abnormal blood circulation  (IAGP)
abnormal brain development  (IAGP)
abnormal brain morphology  (IEA)
abnormal cerebral cortex morphology  (IAGP)
abnormal chorioallantoic fusion  (IAGP)
abnormal cornea epithelium morphology  (IAGP)
abnormal corpus callosum morphology  (IAGP)
abnormal digit morphology  (IEA)
abnormal epidermal layer morphology  (IAGP)
abnormal forebrain development  (IAGP)
abnormal forebrain morphology  (IAGP)
abnormal hair follicle inner root sheath morphology  (IAGP)
abnormal hair follicle morphology  (IAGP)
abnormal hair growth  (IAGP)
abnormal heart looping  (IAGP)
abnormal heart morphology  (IEA)
abnormal hindbrain development  (IAGP)
abnormal hippocampus molecular cell layer  (IAGP)
abnormal midbrain development  (IAGP)
abnormal neocortex morphology  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal neuron morphology  (IAGP)
abnormal object recognition memory  (IAGP)
abnormal paraxial mesoderm morphology  (IAGP)
abnormal retina morphology  (IEA)
abnormal seminal vesicle morphology  (IEA)
abnormal skin condition  (IAGP)
abnormal somite development  (IAGP)
abnormal spatial reference memory  (IAGP)
abnormal spatial working memory  (IAGP)
abnormal T cell subpopulation ratio  (IAGP)
abnormal thymus morphology  (IEA)
abnormal visceral yolk sac morphology  (IAGP)
abnormal vitelline vascular remodeling  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
absent sebocyte  (IAGP)
arteritis  (IAGP)
astrocytosis  (IAGP)
autoimmune response  (IAGP)
caudal body truncation  (IAGP)
chronic inflammation  (IAGP)
decreased body size  (IAGP)
decreased neuron number  (IAGP)
decreased paired-pulse facilitation  (IAGP)
delayed neural tube closure  (IAGP)
dermatitis  (IAGP)
distended pericardium  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
enlarged lateral ventricles  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
enlarged third ventricle  (IAGP)
enlarged thymus  (IEA)
epidermal cyst  (IAGP)
epidermal hyperplasia  (IAGP)
esophagus hyperplasia  (IAGP)
failure of heart looping  (IAGP)
failure of somite differentiation  (IAGP)
focal hair loss  (IAGP)
gliosis  (IAGP)
glomerulonephritis  (IAGP)
hair follicle degeneration  (IAGP)
hematuria  (IAGP)
hydrocephaly  (IEA)
hyperactivity  (IAGP)
hyperkeratosis  (IAGP)
impaired synaptic plasticity  (IAGP)
increased anti-single stranded DNA antibody level  (IAGP)
increased immunoglobulin level  (IAGP)
increased incidence of corneal inflammation  (IAGP)
increased inflammatory response  (IAGP)
increased leukocyte cell number  (IAGP)
increased lung apoptosis  (IAGP)
increased lung endothelial cell apoptosis  (IAGP)
increased mean corpuscular hemoglobin  (IEA)
increased pulmonary alveolus wall thickness  (IAGP)
increased susceptibility to autoimmune disorder  (IAGP)
increased synaptic depression  (IAGP)
increased urine protein level  (IAGP)
kidney inflammation  (IAGP)
kinked neural tube  (IAGP)
lung hemorrhage  (IAGP)
microgliosis  (IAGP)
neurodegeneration  (IAGP)
no abnormal phenotype detected  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
pulmonary fibrosis  (IAGP)
reduced long-term potentiation  (IAGP)
scaly skin  (IAGP)
short hair  (IAGP)
skin inflammation  (IAGP)
skin lesions  (IAGP)
small heart  (IAGP)
small second pharyngeal arch  (IAGP)
spontaneous skin ulceration  (IAGP)
thick epidermis  (IAGP)
thick skin  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. The role of presenilin 1 in the genetics of Alzheimer's disease. Clark RF, etal., Cold Spring Harb Symp Quant Biol 1996;61:551-8.
2. Cell and molecular biology of Notch. Fiuza UM and Arias AM, J Endocrinol. 2007 Sep;194(3):459-74.
3. Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency. Herreman A, etal., Proc Natl Acad Sci U S A 1999 Oct 12;96(21):11872-7.
4. Isolation and characterization of novel presenilin binding protein. Kashiwa A, etal., J Neurochem 2000 Jul;75(1):109-16.
5. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
6. Familial Alzheimer's disease: site of mutation influences clinical phenotype. Lippa CF, etal., Ann Neurol. 2000 Sep;48(3):376-9.
7. Uncommon polymorphism in the presenilin genes in human familial Alzheimer's disease: not to be mistaken with a pathogenic mutation. Lleo A, etal., Neurosci Lett 2002 Feb 1;318(3):166-8.
8. MGDs mouse GO annotations MGD data from the GO Consortium
9. MGD IEA MGD IEA
10. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. Mouse MP Annotation Import Pipeline RGD automated import pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Functional characterization of novel presenilin-2 variants identified in human breast cancers. To MD, etal., Oncogene. 2006 Jun 15;25(25):3557-64. Epub 2006 Feb 13.
Additional References at PubMed
PMID:8533168   PMID:8560270   PMID:8755489   PMID:8889548   PMID:8922407   PMID:8940094   PMID:8990127   PMID:9090377   PMID:9153393   PMID:9203550   PMID:9246482   PMID:9353287  
PMID:9450754   PMID:9535056   PMID:9648880   PMID:9928488   PMID:9950750   PMID:10206645   PMID:10349636   PMID:10356989   PMID:10497236   PMID:10537029   PMID:10557208   PMID:10662508  
PMID:10846187   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11104755   PMID:11172053   PMID:11518718   PMID:11567612   PMID:11715026   PMID:11719200   PMID:11756438   PMID:11817902  
PMID:11904448   PMID:11937492   PMID:11943765   PMID:12039862   PMID:12093789   PMID:12198112   PMID:12388777   PMID:12460542   PMID:12477932   PMID:12646573   PMID:12684521   PMID:12885769  
PMID:14566063   PMID:14610273   PMID:14717705   PMID:15066262   PMID:15122901   PMID:15128703   PMID:15148382   PMID:15264228   PMID:15274632   PMID:15280425   PMID:15287885   PMID:15322084  
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PMID:16000382   PMID:16103123   PMID:16103124   PMID:16141072   PMID:16141073   PMID:16169548   PMID:16204356   PMID:16384915   PMID:16394273   PMID:16602821   PMID:16641999   PMID:16887746  
PMID:17097608   PMID:17121184   PMID:17222949   PMID:17292944   PMID:17499883   PMID:17556541   PMID:17614943   PMID:17626841   PMID:17698590   PMID:17728018   PMID:17874292   PMID:17920016  
PMID:17980611   PMID:18195359   PMID:18287559   PMID:18293935   PMID:18297083   PMID:18297084   PMID:18367332   PMID:18440065   PMID:18507503   PMID:18539391   PMID:18591429   PMID:18665263  
PMID:18803281   PMID:18822370   PMID:18834536   PMID:18971484   PMID:19005074   PMID:19111578   PMID:19297528   PMID:19369394   PMID:19376115   PMID:19382908   PMID:19457123   PMID:19494151  
PMID:19573580   PMID:19573812   PMID:19584449   PMID:19641596   PMID:19656855   PMID:19723764   PMID:19779553   PMID:19834068   PMID:20130175   PMID:20208556   PMID:20573903   PMID:20854432  
PMID:20875805   PMID:20926667   PMID:20953898   PMID:20974250   PMID:21084199   PMID:21146496   PMID:21206757   PMID:21267068   PMID:21285369   PMID:21414900   PMID:21597003   PMID:21677750  
PMID:21703454   PMID:21873635   PMID:21910732   PMID:21914807   PMID:22002539   PMID:22140537   PMID:22170863   PMID:22311977   PMID:22496554   PMID:22505025   PMID:22715045   PMID:22723704  
PMID:22796216   PMID:22897852   PMID:22935613   PMID:23083742   PMID:23103503   PMID:23341629   PMID:23359614   PMID:23365231   PMID:23370287   PMID:23589300   PMID:23792007   PMID:23918386  
PMID:23924630   PMID:23952003   PMID:24018889   PMID:24145027   PMID:24353058   PMID:24699228   PMID:24858037   PMID:24952961   PMID:25204494   PMID:25429133   PMID:25574842   PMID:25652771  
PMID:25741723   PMID:25995356   PMID:26081153   PMID:26593275   PMID:27177724   PMID:27239030   PMID:27240887   PMID:27349870   PMID:27354375   PMID:27889678   PMID:28215940   PMID:28619096  
PMID:28879407   PMID:28994238   PMID:29229705   PMID:29623612   PMID:29867447   PMID:30059908   PMID:30316051   PMID:30429473   PMID:30559648   PMID:30560948   PMID:31376499   PMID:31433986  
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PMID:38791456  


Genomics

Comparative Map Data
Psen2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391180,054,569 - 180,091,030 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1180,054,569 - 180,091,003 (-)EnsemblGRCm39 Ensembl
GRCm381180,227,004 - 180,263,467 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1180,227,004 - 180,263,438 (-)EnsemblGRCm38mm10GRCm38
MGSCv371182,157,135 - 182,186,431 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361182,063,681 - 182,082,576 (-)NCBIMGSCv36mm8
Celera1187,291,668 - 187,320,266 (-)NCBICelera
Cytogenetic Map1H4NCBI
cM Map184.19NCBI
PSEN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381226,870,616 - 226,903,668 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1226,870,184 - 226,927,726 (+)EnsemblGRCh38hg38GRCh38
GRCh371227,058,317 - 227,083,799 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361225,124,896 - 225,150,427 (+)NCBINCBI36Build 36hg18NCBI36
Build 341223,365,694 - 223,390,532NCBI
Celera1200,249,068 - 200,274,610 (+)NCBICelera
Cytogenetic Map1q42.13NCBI
HuRef1197,575,178 - 197,600,711 (+)NCBIHuRef
CHM1_11228,331,030 - 228,356,564 (+)NCBICHM1_1
T2T-CHM13v2.01226,058,503 - 226,091,743 (+)NCBIT2T-CHM13v2.0
Psen2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81394,499,451 - 94,528,419 (-)NCBIGRCr8
mRatBN7.21391,967,506 - 91,993,240 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1391,967,983 - 91,993,174 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1394,473,112 - 94,489,800 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01395,873,282 - 95,889,973 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01393,047,983 - 93,064,680 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01398,513,600 - 98,539,347 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1398,513,570 - 98,530,724 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013103,521,460 - 103,547,174 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41395,934,674 - 95,951,836 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11396,123,177 - 96,145,989 (-)NCBI
Celera1391,515,731 - 91,532,398 (-)NCBICelera
Cytogenetic Map13q26NCBI
Psen2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554065,727,367 - 5,752,234 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554065,727,367 - 5,748,798 (+)NCBIChiLan1.0ChiLan1.0
PSEN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2122,644,288 - 22,669,733 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1122,592,732 - 22,618,185 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01202,328,987 - 202,354,440 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11207,320,937 - 207,346,295 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1207,320,937 - 207,346,295 (+)Ensemblpanpan1.1panPan2
PSEN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1738,147,157 - 38,163,023 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl738,147,173 - 38,166,722 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha737,629,753 - 37,654,335 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0737,981,322 - 38,006,377 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl737,980,700 - 38,006,369 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1737,820,678 - 37,845,261 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0737,827,826 - 37,852,402 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0738,098,241 - 38,122,853 (-)NCBIUU_Cfam_GSD_1.0
Psen2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934451,135,578 - 51,163,137 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365263,584,188 - 3,614,074 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365263,584,194 - 3,611,719 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PSEN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1014,532,767 - 14,577,251 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11014,532,556 - 14,561,862 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21016,862,708 - 16,891,775 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap10p16-p11NCBI
PSEN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1252,862,354 - 2,888,735 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl252,862,251 - 2,877,386 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660552,849,316 - 2,875,698 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Psen2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477117,183,447 - 17,224,188 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477117,183,538 - 17,205,460 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Psen2
2432 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1869
Count of miRNA genes:617
Interacting mature miRNAs:771
Transcripts:ENSMUST00000010753, ENSMUST00000111104, ENSMUST00000111105, ENSMUST00000111106, ENSMUST00000111108, ENSMUST00000128223, ENSMUST00000130029, ENSMUST00000130711, ENSMUST00000133340, ENSMUST00000136291, ENSMUST00000149590
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
4141245Cq2_mcholesterol QTL 2 (mouse)Not determined1157456299191456436Mouse
4141244Bmd5c_mbone mineral density 5c (mouse)Not determined155526796189526897Mouse
1558802Skmw6_mskeletal muscle weight 6 (mouse)Not determined1167954584195154279Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
13464138Hdlq107_mHDL QTL 107 (mouse)1152132744186132744Mouse
1301652Cpfd2_mcerebellum pattern fissures (mouse)Not determined1172303451195154279Mouse
12790987Tgl5_mtriglyceride 5 (mouse)1160097157194097157Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
4142389Scfr1_mstem cell frequency regulator 1 (mouse)Not determined171632048189303617Mouse
12790984Pcho7_mplasma cholesterol 7 (mouse)1147219390181219390Mouse
1300888Berr1_mberghei resistance locus 1 (mouse)Not determined1164143227190534272Mouse
12790988Phdlc5_mplasma HDL cholesterol 5 (mouse)9160097157194097157Mouse
1301251Scc3_mcolon tumor susceptibility 3 (mouse)Not determined1168213823195154279Mouse
1301122Cd8mts1_mCD8 T memory cell subset 1 (mouse)Not determined1155831765189831892Mouse
1301632Bw8q1_mbody weight at 8 weeks QTL 1 (mouse)Not determined1161201261195154279Mouse
4141483Femwf7_mfemur work to failure 7 (mouse)Not determined167462514195154279Mouse
1302023Orch4_mautoimmune orchitis resistance 4 (mouse)Not determined1175211318195154279Mouse
1301385Radpf2_mradiation pulmonary fibrosis 2 (mouse)Not determined1147125258182873798Mouse
12791001Aath6_maortic arch atherosclerosis 6 (mouse)1147219390181219390Mouse
1300745Gvhd1_mgraft-versus-host disease 1 (mouse)Not determined1157456299191456436Mouse
10412162Nobq3_mNew Zealand obese QTL 3 (mouse)Not determined1103933405191225397Mouse
4141346Skmw12_mskeletal muscle weight 12 (mouse)Not determined150756737184756922Mouse
1301134Bmd1_mbone mineral density 1 (mouse)Not determined1156602037189303617Mouse
1302158Fembrs5_mfemur breaking strength 5 (mouse)Not determined1167462514195154279Mouse
1301132Mors1_mmodifier of obesity related sterility 1 (mouse)Not determined1170379500195154279Mouse
1357493Lgaq3_mlate growth adjusted QTL 3 (mouse)Not determined1150193673188359312Mouse
11251722Ewc1_methanol withdrawal and consumption 1 (mouse)1152132744186132744Mouse
10043963Obq25_mobesity QTL 25 (mouse)Not determined1154410512188410512Mouse
1301431Pcho1_mplasma cholesterol 1 (mouse)Not determined1159262573193262693Mouse
1357618Splq5_mspleen weight QTL 5 (mouse)Not determined1150193673188359312Mouse
1301301Sle1_msystemic lupus erythmatosus susceptibility 1 (mouse)Not determined1152038741186038913Mouse
10045887Cplaq13_mcircadian period of locomotor activity 13 (mouse)Not determined1172831765181400659Mouse
12904936Edlmmq1_mextensor digitorum longus muscle mass QTL 1 (mouse)1155002940189002940Mouse
1301565Mnotch_mmodifier of Notch (mouse)Not determined1157456299191456436Mouse
1301309Emo1_memotionality 1 (mouse)Not determined1162977097185994196Mouse
1357732Tbbmd1_mtotal body bone mineral density 1 (mouse)Not determined1171983110195154279Mouse
1301025Lbw7_mlupus NZB x NZW 7 (mouse)Not determined1152038741186038913Mouse
10412074Nhdlt1_mnon-HDL cholesterol and triglyceride levels 1 (mouse)Not determined1153675990187676105Mouse
12904944Tammq1_mtibialis anterior muscle mass QTL 1 (mouse)1155002940189002940Mouse
1357485Lgq4_mlate growth QTL 4 (mouse)Not determined1150193673188359312Mouse
12904957Gmmq1_mgastrocnemius muscle mass QTL 1 (mouse)1155002940189002940Mouse
1300777Chol10_mcholesterol 10 (mouse)Not determined9147875502181875616Mouse
11532690Sluc37_msusceptibility to lung cancer 37 (mouse)1175468817194111528Mouse
1301932Ssta2_msusceptibility to Salmonella typhimurium antigens 2 (mouse)Not determined1155716221189716369Mouse
1301202Yaa4_mY-linked autoimmune acceleration 4 (mouse)Not determined1158468817192468938Mouse
10054490Opefa_mopen field activity (mouse)Not determined1153712853187712853Mouse
1300823Ath9_matherosclerosis 9 (mouse)Not determined1160112768194112883Mouse
1301333Mop3_mmorphine preference 3 (mouse)Not determined1167756737189303617Mouse
1300948Fglu2_mfasting glucose 2 (mouse)Not determined1157456299191456436Mouse
1301339Hdlq15_mHDL QTL 15 (mouse)Not determined1165873675195154279Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
11059556Lmr20b_mleishmaniasis resistance 20b (mouse)1158468817192468938Mouse
4141554Cfmq1_mcystic fibrosis modifier QTL 1 (mouse)Not determined1152038741186038913Mouse
11059557Lmr20a_mleishmaniasis resistance 20a (mouse)1158468817192468938Mouse
11059558Lmr20c_mleishmaniasis resistance 20c (mouse)1158468817192468938Mouse
10043863Swrl5_mSWR lupus locus 5 (mouse)Not determined1172303451195154279Mouse
1301596Elnt_mescape latencies during navigation task (mouse)Not determined1162145207194111528Mouse
11049575Lmr8b_mleishmaniasis resistance 8b (mouse)1172303451195154279Mouse
4141165Bglu3_mblood glucose level 3 (mouse)Not determined155831765189831892Mouse
12792983Liq1_mlimb inflammation QTL 1 (mouse)1167586086191225397Mouse
1357889Lprq3_mlipoprotein QTL 3 (mouse)Not determined1152038741186038913Mouse
1301189Lmr8_mleishmaniasis resistance 8 (mouse)Not determined1156602037189303617Mouse
4142182Shali5_msurvival time to hyperoxic acute lung injury 5 (mouse)Not determined155582237185994196Mouse
10766456Sle21_msystematic lupus erythematosus susceptibility 21 (mouse)1155831765189831892Mouse
10402498Lmr20_mleishmaniasis resistance 20 (mouse)Not determined1158468817192468938Mouse
1301619Cafq1_mcaffeine metabolism QTL 1 (mouse)Not determined1155716221189716369Mouse
27095935Ulnl5_mulna length 5, 10 week (mouse)1128727737181327565Mouse
4141149Hbnr4_mHeligmosomoides bakeri nematode resistance 4 (mouse)Not determined147125258188983224Mouse
10043899Hdlq99_mHDL QTL 99 (mouse)Not determined1147875502181875616Mouse
1300727Mptp1_mMPTP sensitivity 1 (mouse)Not determined1171632048192681050Mouse
10054271Nba9_mNew Zealand Black autoimmunity 9 (mouse)Not determined1155525623189527533Mouse
11081167Tir8_mtrypanosome infection response 8 (mouse)1155716221189716369Mouse
10054270Nba10_mNew Zealand Black autoimmunity 10 (mouse)Not determined1152794822186438620Mouse
1302132Pbw1_mpentobarbital withdrawal QTL 1 (mouse)Not determined1155831765189831892Mouse
1559024Zit1_mzinc induced tolerance 1 (mouse)Not determined1167462514195154279Mouse
12880429V25Dq1_mvitamin D inactive form serum level QTL 1 (mouse)1172632197195154279Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
12880426V25Dq2_mvitamin D inactive form serum level QTL 2 (mouse)1172532197195154279Mouse
1300732Melm2_mmelanoma modifier 2 (mouse)Not determined1157456299191456436Mouse
4142159Nba2_mNew Zealand Black autoimmunity 2 (mouse)Not determined151835111185835280Mouse
1301602Bslm4_mbasal locomotor activity 4 (mouse)Not determined1157456299191456436Mouse
1301216Cbm1_mcerebellum weight 1 (mouse)Not determined1157456299191456436Mouse
1300960Hpic2_mhaloperidol induced catalepsy 2 (mouse)Not determined1175468817181400659Mouse
1301866Cplaq3_mcircadian period of locomotor activity 3 (mouse)Not determined1155721528189722608Mouse
1300842Sle9_msystematic lupus erythematosus susceptibility 9 (mouse)Not determined1158468817192468938Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)175976637181327565Mouse
1300969Sluc5_msusceptibility to lung cancer 5 (mouse)Not determined1151186243185186402Mouse
1301614Cgnz1_mchronic glomerulonephritis in NZM 1 (mouse)Not determined1152038741186038913Mouse

Markers in Region
AI266870  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381180,227,192 - 180,227,295UniSTSGRCm38
MGSCv371182,157,323 - 182,157,426UniSTSGRCm37
Celera1187,291,856 - 187,291,959UniSTS
Cytogenetic Map1H4UniSTS
cM Map1101.0UniSTS
Whitehead/MRC_RH12255.55UniSTS
Psen2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1H4UniSTS
cM Map1 UniSTS
PMC317124P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381180,245,343 - 180,245,694UniSTSGRCm38
MGSCv371182,175,474 - 182,175,825UniSTSGRCm37
Celera1187,309,199 - 187,309,550UniSTS
Cytogenetic Map1H4UniSTS
cM Map1101.0UniSTS
PMC317124P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381180,235,771 - 180,235,972UniSTSGRCm38
MGSCv371182,165,902 - 182,166,103UniSTSGRCm37
Celera1187,300,389 - 187,300,590UniSTS
Cytogenetic Map1H4UniSTS
cM Map1101.0UniSTS
PMC317124P3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381180,238,241 - 180,238,890UniSTSGRCm38
MGSCv371182,168,372 - 182,169,021UniSTSGRCm37
Celera1187,302,928 - 187,303,577UniSTS
Cytogenetic Map1H4UniSTS
cM Map1101.0UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001128605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001420470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001420471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001420472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_185180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_185181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_185182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_185183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_185184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011238776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC132436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF038935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI118332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK014706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK077576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY864737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC010403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM935552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY136632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U49111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U57324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U57325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000010753   ⟹   ENSMUSP00000010753
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1180,054,571 - 180,073,515 (-)Ensembl
GRCm38.p6 Ensembl1180,227,006 - 180,245,950 (-)Ensembl
Ensembl Acc Id: ENSMUST00000111104   ⟹   ENSMUSP00000106733
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1180,055,010 - 180,073,322 (-)Ensembl
GRCm38.p6 Ensembl1180,227,445 - 180,245,757 (-)Ensembl
Ensembl Acc Id: ENSMUST00000111105   ⟹   ENSMUSP00000106734
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1180,055,008 - 180,075,715 (-)Ensembl
GRCm38.p6 Ensembl1180,227,443 - 180,248,150 (-)Ensembl
Ensembl Acc Id: ENSMUST00000111106   ⟹   ENSMUSP00000106735
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1180,054,569 - 180,080,703 (-)Ensembl
GRCm38.p6 Ensembl1180,227,004 - 180,253,138 (-)Ensembl
Ensembl Acc Id: ENSMUST00000111108   ⟹   ENSMUSP00000106737
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1180,054,569 - 180,083,865 (-)Ensembl
GRCm38.p6 Ensembl1180,227,004 - 180,256,300 (-)Ensembl
Ensembl Acc Id: ENSMUST00000128223
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1180,062,739 - 180,066,787 (-)Ensembl
GRCm38.p6 Ensembl1180,235,174 - 180,239,222 (-)Ensembl
Ensembl Acc Id: ENSMUST00000130029
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1180,055,033 - 180,057,590 (-)Ensembl
GRCm38.p6 Ensembl1180,227,468 - 180,230,025 (-)Ensembl
Ensembl Acc Id: ENSMUST00000130711
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1180,054,569 - 180,057,630 (-)Ensembl
GRCm38.p6 Ensembl1180,227,004 - 180,230,065 (-)Ensembl
Ensembl Acc Id: ENSMUST00000133340   ⟹   ENSMUSP00000120216
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1180,073,203 - 180,091,003 (-)Ensembl
GRCm38.p6 Ensembl1180,245,638 - 180,263,438 (-)Ensembl
Ensembl Acc Id: ENSMUST00000136291
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1180,054,954 - 180,057,627 (-)Ensembl
GRCm38.p6 Ensembl1180,227,389 - 180,230,062 (-)Ensembl
Ensembl Acc Id: ENSMUST00000149590
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1180,060,089 - 180,083,809 (-)Ensembl
GRCm38.p6 Ensembl1180,232,524 - 180,256,244 (-)Ensembl
Ensembl Acc Id: ENSMUST00000193897
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1180,054,571 - 180,057,133 (-)Ensembl
GRCm38.p6 Ensembl1180,227,006 - 180,229,568 (-)Ensembl
RefSeq Acc Id: NM_001128605   ⟹   NP_001122077
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391180,054,569 - 180,083,816 (-)NCBI
GRCm381180,227,004 - 180,256,300 (-)NCBI
MGSCv371182,157,135 - 182,186,431 (-)RGD
Celera1187,291,668 - 187,320,266 (-)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001420470   ⟹   NP_001407399
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391180,054,569 - 180,083,816 (-)NCBI
RefSeq Acc Id: NM_001420471   ⟹   NP_001407400
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391180,054,569 - 180,057,627 (-)NCBI
RefSeq Acc Id: NM_001420472   ⟹   NP_001407401
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391180,054,569 - 180,057,627 (-)NCBI
RefSeq Acc Id: NM_011183   ⟹   NP_035313
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391180,054,569 - 180,073,498 (-)NCBI
GRCm381180,227,004 - 180,245,950 (-)NCBI
MGSCv371182,157,135 - 182,186,431 (-)RGD
Celera1187,291,668 - 187,320,266 (-)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_185180
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391180,054,569 - 180,083,816 (-)NCBI
RefSeq Acc Id: NR_185181
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391180,054,569 - 180,057,627 (-)NCBI
RefSeq Acc Id: NR_185182
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391180,054,569 - 180,057,627 (-)NCBI
RefSeq Acc Id: NR_185183
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391180,054,569 - 180,057,627 (-)NCBI
RefSeq Acc Id: NR_185184
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391180,054,569 - 180,057,627 (-)NCBI
RefSeq Acc Id: XM_011238776   ⟹   XP_011237078
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391180,054,569 - 180,091,030 (-)NCBI
GRCm381180,227,004 - 180,263,467 (-)NCBI
Sequence:
RefSeq Acc Id: NP_035313   ⟸   NM_011183
- Peptide Label: isoform 1
- UniProtKB: Q9D616 (UniProtKB/Swiss-Prot),   Q91VS3 (UniProtKB/Swiss-Prot),   P97935 (UniProtKB/Swiss-Prot),   P97934 (UniProtKB/Swiss-Prot),   O54977 (UniProtKB/Swiss-Prot),   Q61144 (UniProtKB/Swiss-Prot),   Q3U4P5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001122077   ⟸   NM_001128605
- Peptide Label: isoform 1
- UniProtKB: Q9D616 (UniProtKB/Swiss-Prot),   Q91VS3 (UniProtKB/Swiss-Prot),   P97935 (UniProtKB/Swiss-Prot),   P97934 (UniProtKB/Swiss-Prot),   O54977 (UniProtKB/Swiss-Prot),   Q61144 (UniProtKB/Swiss-Prot),   Q3U4P5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011237078   ⟸   XM_011238776
- Peptide Label: isoform X1
- UniProtKB: Q9D616 (UniProtKB/Swiss-Prot),   Q91VS3 (UniProtKB/Swiss-Prot),   P97935 (UniProtKB/Swiss-Prot),   P97934 (UniProtKB/Swiss-Prot),   O54977 (UniProtKB/Swiss-Prot),   Q61144 (UniProtKB/Swiss-Prot),   Q3U4P5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000106737   ⟸   ENSMUST00000111108
Ensembl Acc Id: ENSMUSP00000106733   ⟸   ENSMUST00000111104
Ensembl Acc Id: ENSMUSP00000106734   ⟸   ENSMUST00000111105
Ensembl Acc Id: ENSMUSP00000106735   ⟸   ENSMUST00000111106
Ensembl Acc Id: ENSMUSP00000120216   ⟸   ENSMUST00000133340
Ensembl Acc Id: ENSMUSP00000010753   ⟸   ENSMUST00000010753
RefSeq Acc Id: NP_001407399   ⟸   NM_001420470
- Peptide Label: isoform 2
- UniProtKB: Q9D616 (UniProtKB/Swiss-Prot),   Q91VS3 (UniProtKB/Swiss-Prot),   Q61144 (UniProtKB/Swiss-Prot),   P97935 (UniProtKB/Swiss-Prot),   P97934 (UniProtKB/Swiss-Prot),   O54977 (UniProtKB/Swiss-Prot),   A0A0R4J1F2 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001407401   ⟸   NM_001420472
- Peptide Label: isoform 4
RefSeq Acc Id: NP_001407400   ⟸   NM_001420471
- Peptide Label: isoform 3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61144-F1-model_v2 AlphaFold Q61144 1-448 view protein structure

Promoters
RGD ID:6875908
Promoter ID:EPDNEW_M1405
Type:initiation region
Name:Psen2_2
Description:Mus musculus presenilin 2 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M1406  EPDNEW_M1407  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381180,229,966 - 180,230,026EPDNEW
RGD ID:6875910
Promoter ID:EPDNEW_M1406
Type:initiation region
Name:Psen2_3
Description:Mus musculus presenilin 2 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M1405  EPDNEW_M1407  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381180,245,933 - 180,245,993EPDNEW
RGD ID:6875912
Promoter ID:EPDNEW_M1407
Type:multiple initiation site
Name:Psen2_1
Description:Mus musculus presenilin 2 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M1405  EPDNEW_M1406  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381180,256,251 - 180,256,311EPDNEW
RGD ID:6818290
Promoter ID:MM_KWN:3113
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:OTTMUST00000050932,   OTTMUST00000050933,   OTTMUST00000050934
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361182,159,841 - 182,160,341 (-)MPROMDB
RGD ID:6818288
Promoter ID:MM_KWN:3114
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:OTTMUST00000050931
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361182,169,261 - 182,169,761 (-)MPROMDB
RGD ID:6818291
Promoter ID:MM_KWN:3115
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver,   Lung,   Spleen
Transcripts:ENSMUST00000010753,   UC007DWB.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361182,175,724 - 182,176,224 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109284 AgrOrtholog
Ensembl Genes ENSMUSG00000010609 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000010753 ENTREZGENE
  ENSMUST00000010753.14 UniProtKB/TrEMBL
  ENSMUST00000111104 ENTREZGENE
  ENSMUST00000111104.2 UniProtKB/TrEMBL
  ENSMUST00000111105.8 UniProtKB/TrEMBL
  ENSMUST00000111106.8 UniProtKB/TrEMBL
  ENSMUST00000111108 ENTREZGENE
  ENSMUST00000111108.10 UniProtKB/TrEMBL
  ENSMUST00000130711 ENTREZGENE
  ENSMUST00000133340.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.472.100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Pept_A22A_PS2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_A22A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Preselin/SPP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Presenilin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:19165 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:109284 ENTREZGENE
NCBI Gene 19165 ENTREZGENE
PANTHER PRESENILIN-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10202 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Presenilin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Psen2 PhenoGen
PRINTS PRESENILIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRESENILIN2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0R4J1F2 ENTREZGENE, UniProtKB/TrEMBL
  D3Z0X1_MOUSE UniProtKB/TrEMBL
  O54977 ENTREZGENE
  P97934 ENTREZGENE
  P97935 ENTREZGENE
  PSN2_MOUSE UniProtKB/Swiss-Prot
  Q3U4P5 ENTREZGENE, UniProtKB/TrEMBL
  Q5EM20_MOUSE UniProtKB/TrEMBL
  Q61144 ENTREZGENE
  Q91VS3 ENTREZGENE
  Q9D616 ENTREZGENE
UniProt Secondary O54977 UniProtKB/Swiss-Prot
  P97934 UniProtKB/Swiss-Prot
  P97935 UniProtKB/Swiss-Prot
  Q91VS3 UniProtKB/Swiss-Prot
  Q9D616 UniProtKB/Swiss-Prot