PNOC (prepronociceptin) - Rat Genome Database

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Gene: PNOC (prepronociceptin) Homo sapiens
Analyze
Symbol: PNOC
Name: prepronociceptin
RGD ID: 733566
HGNC Page HGNC:9163
Description: Predicted to enable opioid receptor binding activity. Predicted to be involved in chemical synaptic transmission; neuropeptide signaling pathway; and sensory perception. Predicted to act upstream of or within signal transduction. Predicted to be located in extracellular region. Predicted to be active in several cellular components, including axon terminus; neuronal cell body; and synaptic membrane. Implicated in neonatal abstinence syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: N/OFQ; nociceptin; nocistatin; NOP; OFQ; orphanin FQ; ppN/OFQ; PPNOC; pre-pro-N/OFQ; pronociceptin; propronociceptin
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38828,316,988 - 28,343,351 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl828,316,986 - 28,343,355 (+)EnsemblGRCh38hg38GRCh38
GRCh37828,174,785 - 28,200,868 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36828,230,568 - 28,256,787 (+)NCBINCBI36Build 36hg18NCBI36
Build 34828,230,567 - 28,256,786NCBI
Celera827,134,504 - 27,160,720 (+)NCBICelera
Cytogenetic Map8p21.1NCBI
HuRef826,719,942 - 26,746,164 (+)NCBIHuRef
CHM1_1828,376,658 - 28,402,833 (+)NCBICHM1_1
T2T-CHM13v2.0828,595,062 - 28,621,518 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Variations in opioid receptor genes in neonatal abstinence syndrome. Wachman EM, etal., Drug Alcohol Depend. 2015 Oct 1;155:253-9. doi: 10.1016/j.drugalcdep.2015.07.001. Epub 2015 Jul 8.
4. Prenatal ethanol induces an anxiety phenotype and alters expression of dynorphin & nociceptin/orphanin FQ genes. Wille-Bille A, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jul 13;85:77-88. doi: 10.1016/j.pnpbp.2018.04.005. Epub 2018 Apr 18.
5. Immunomodulatory activity of orphanin FQ/nociceptin on traumatic rats. Zhao H, etal., Acta Pharmacol Sin. 2002 Apr;23(4):343-8.
Additional References at PubMed
PMID:8662940   PMID:8710928   PMID:8710930   PMID:8735615   PMID:8844779   PMID:9168905   PMID:9257731   PMID:9262184   PMID:9409745   PMID:9521323   PMID:9521621   PMID:9559929  
PMID:9822213   PMID:10025089   PMID:10082806   PMID:10101606   PMID:10380976   PMID:10419552   PMID:10570970   PMID:10655922   PMID:10692489   PMID:10812065   PMID:10998544   PMID:11027536  
PMID:11097863   PMID:11165763   PMID:11214319   PMID:11318773   PMID:11331401   PMID:11403992   PMID:11436130   PMID:11501941   PMID:11568656   PMID:11696742   PMID:11719021   PMID:11855841  
PMID:12062800   PMID:12128158   PMID:12217418   PMID:12225892   PMID:12352616   PMID:12371703   PMID:12477932   PMID:12576178   PMID:12736013   PMID:12812047   PMID:12950177   PMID:14695766  
PMID:14695788   PMID:14715146   PMID:14970396   PMID:15020071   PMID:15030536   PMID:15351928   PMID:15489334   PMID:15773823   PMID:15922491   PMID:16042989   PMID:16043263   PMID:16344560  
PMID:17910740   PMID:18247127   PMID:18292431   PMID:19058789   PMID:19501074   PMID:19560501   PMID:19573600   PMID:19874574   PMID:20100531   PMID:20379614   PMID:20413378   PMID:20589874  
PMID:20888736   PMID:21079395   PMID:21310194   PMID:21324928   PMID:21547539   PMID:21600132   PMID:21744319   PMID:21873635   PMID:22706982   PMID:23382691   PMID:23395957   PMID:23454174  
PMID:24066107   PMID:24124588   PMID:24189487   PMID:24228146   PMID:25677768   PMID:25677772   PMID:25677773   PMID:25677774   PMID:25677775   PMID:25677776   PMID:25677777   PMID:25677778  
PMID:25716007   PMID:26349406   PMID:26791055   PMID:27503909   PMID:27983768   PMID:33841428   PMID:33961781  


Genomics

Comparative Map Data
PNOC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38828,316,988 - 28,343,351 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl828,316,986 - 28,343,355 (+)EnsemblGRCh38hg38GRCh38
GRCh37828,174,785 - 28,200,868 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36828,230,568 - 28,256,787 (+)NCBINCBI36Build 36hg18NCBI36
Build 34828,230,567 - 28,256,786NCBI
Celera827,134,504 - 27,160,720 (+)NCBICelera
Cytogenetic Map8p21.1NCBI
HuRef826,719,942 - 26,746,164 (+)NCBIHuRef
CHM1_1828,376,658 - 28,402,833 (+)NCBICHM1_1
T2T-CHM13v2.0828,595,062 - 28,621,518 (+)NCBIT2T-CHM13v2.0
Pnoc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391465,638,931 - 65,662,908 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1465,638,122 - 65,662,921 (-)EnsemblGRCm39 Ensembl
GRCm381465,400,673 - 65,425,564 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1465,400,673 - 65,425,472 (-)EnsemblGRCm38mm10GRCm38
MGSCv371466,019,510 - 66,044,046 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361464,354,783 - 64,379,319 (-)NCBIMGSCv36mm8
Celera1463,152,191 - 63,176,787 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1434.33NCBI
Pnoc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81543,800,240 - 43,827,841 (-)NCBIGRCr8
mRatBN7.21539,624,635 - 39,652,463 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1539,624,641 - 39,651,867 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1541,488,469 - 41,501,440 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01542,638,659 - 42,651,630 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01541,085,000 - 41,097,863 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01548,805,841 - 48,833,071 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1548,805,228 - 48,833,285 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01552,547,677 - 52,574,687 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41544,822,635 - 44,835,637 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11544,838,334 - 44,851,337 (-)NCBI
Celera1539,298,658 - 39,311,512 (-)NCBICelera
Cytogenetic Map15p12NCBI
Pnoc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540350,735,390 - 50,755,902 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540350,735,567 - 50,755,892 (+)NCBIChiLan1.0ChiLan1.0
PNOC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2746,856,738 - 46,883,138 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1822,571,113 - 22,597,566 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0827,596,413 - 27,622,844 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1824,796,490 - 24,822,764 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl824,796,638 - 24,822,758 (+)Ensemblpanpan1.1panPan2
PNOC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12529,223,758 - 29,246,487 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2529,224,092 - 29,245,851 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2529,873,540 - 29,896,041 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02529,382,377 - 29,404,891 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2529,382,715 - 29,404,498 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12529,342,437 - 29,364,950 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02529,226,990 - 29,249,199 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02529,393,029 - 29,415,545 (-)NCBIUU_Cfam_GSD_1.0
Pnoc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049437,451,235 - 7,473,199 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366751,113,435 - 1,134,910 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366751,113,435 - 1,134,916 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PNOC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1412,101,698 - 12,133,778 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11412,101,223 - 12,134,174 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21413,256,659 - 13,288,651 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PNOC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1826,418,473 - 26,444,689 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl826,418,815 - 26,444,677 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605215,687,564 - 15,713,855 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pnoc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475823,007,573 - 23,028,704 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475823,007,530 - 23,026,962 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PNOC
17 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8p23.1-11.21(chr8:12609975-42085703)x3 copy number gain See cases [RCV000050294] Chr8:12609975..42085703 [GRCh38]
Chr8:12467484..41943221 [GRCh37]
Chr8:12511855..42062378 [NCBI36]
Chr8:8p23.1-11.21
pathogenic
GRCh38/hg38 8p21.2-q11.21(chr8:25832130-48521849)x3 copy number gain See cases [RCV000050904] Chr8:25832130..48521849 [GRCh38]
Chr8:25689646..49434409 [GRCh37]
Chr8:25745563..49596962 [NCBI36]
Chr8:8p21.2-q11.21
pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12728904-43673207)x3 copy number gain See cases [RCV000050912] Chr8:12728904..43673207 [GRCh38]
Chr8:12586413..43528350 [GRCh37]
Chr8:12630784..43647507 [NCBI36]
Chr8:8p23.1-11.1
pathogenic
GRCh38/hg38 8p23.1-12(chr8:12383584-36370018)x3 copy number gain See cases [RCV000051145] Chr8:12383584..36370018 [GRCh38]
Chr8:12241093..36227536 [GRCh37]
Chr8:12285464..36347088 [NCBI36]
Chr8:8p23.1-12
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.1-11.21(chr8:12728904-41928741)x3 copy number gain See cases [RCV000051110] Chr8:12728904..41928741 [GRCh38]
Chr8:12586413..41786259 [GRCh37]
Chr8:12630784..41905416 [NCBI36]
Chr8:8p23.1-11.21
pathogenic
GRCh38/hg38 8p23.1-11.23(chr8:12609975-37892000)x3 copy number gain See cases [RCV000053629] Chr8:12609975..37892000 [GRCh38]
Chr8:12467484..37749518 [GRCh37]
Chr8:12511855..37868676 [NCBI36]
Chr8:8p23.1-11.23
pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12609975-43336172)x3 copy number gain See cases [RCV000053630] Chr8:12609975..43336172 [GRCh38]
Chr8:12467484..43191315 [GRCh37]
Chr8:12511855..43310472 [NCBI36]
Chr8:8p23.1-11.1
pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12609975-43255410)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053631]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053631]|See cases [RCV000053631] Chr8:12609975..43255410 [GRCh38]
Chr8:12467484..43110553 [GRCh37]
Chr8:12511855..43229710 [NCBI36]
Chr8:8p23.1-11.1
pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12750796-43532444)x3 copy number gain See cases [RCV000053632] Chr8:12750796..43532444 [GRCh38]
Chr8:12608305..43387587 [GRCh37]
Chr8:12652676..43506744 [NCBI36]
Chr8:8p23.1-11.1
pathogenic
GRCh38/hg38 8p23.1-12(chr8:12750796-29445409)x3 copy number gain See cases [RCV000053633] Chr8:12750796..29445409 [GRCh38]
Chr8:12608305..29302926 [GRCh37]
Chr8:12652676..29358845 [NCBI36]
Chr8:8p23.1-12
pathogenic
GRCh38/hg38 8p22-q11.21(chr8:14940110-47929925)x3 copy number gain See cases [RCV000053635] Chr8:14940110..47929925 [GRCh38]
Chr8:14797619..48842485 [GRCh37]
Chr8:14841990..49005038 [NCBI36]
Chr8:8p22-q11.21
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-12(chr8:96310-30614703)x3 copy number gain See cases [RCV000053599] Chr8:96310..30614703 [GRCh38]
Chr8:46310..30472220 [GRCh37]
Chr8:36310..30591762 [NCBI36]
Chr8:8p23.3-12
pathogenic
GRCh38/hg38 8p21.2-12(chr8:24910364-31210737)x1 copy number loss See cases [RCV000054237] Chr8:24910364..31210737 [GRCh38]
Chr8:24767877..31068253 [GRCh37]
Chr8:24823781..31187795 [NCBI36]
Chr8:8p21.2-12
pathogenic
GRCh37/hg19 8p23.3-11.1(chr8:176814-43396776) copy number gain Abnormal fetal cardiovascular morphology [RCV001291977] Chr8:176814..43396776 [GRCh37]
Chr8:8p23.3-11.1
pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12609975-43673207)x3 copy number gain See cases [RCV000135786] Chr8:12609975..43673207 [GRCh38]
Chr8:12467484..43528350 [GRCh37]
Chr8:12511855..43647507 [NCBI36]
Chr8:8p23.1-11.1
pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12383584-43673207)x3 copy number gain See cases [RCV000135566] Chr8:12383584..43673207 [GRCh38]
Chr8:12241093..43528350 [GRCh37]
Chr8:12285464..43647507 [NCBI36]
Chr8:8p23.1-11.1
pathogenic
GRCh38/hg38 8p23.1-11.21(chr8:12728904-40169194)x3 copy number gain See cases [RCV000136516] Chr8:12728904..40169194 [GRCh38]
Chr8:12586413..40026713 [GRCh37]
Chr8:12630784..40145870 [NCBI36]
Chr8:8p23.1-11.21
pathogenic
GRCh38/hg38 8p21.2-12(chr8:24910364-31196357)x1 copy number loss See cases [RCV000136120] Chr8:24910364..31196357 [GRCh38]
Chr8:24767877..31053873 [GRCh37]
Chr8:24823781..31173415 [NCBI36]
Chr8:8p21.2-12
pathogenic
GRCh38/hg38 8p23.1-12(chr8:12725750-30180521)x3 copy number gain See cases [RCV000136825] Chr8:12725750..30180521 [GRCh38]
Chr8:12583259..30038037 [GRCh37]
Chr8:12627630..30157579 [NCBI36]
Chr8:8p23.1-12
pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12182421-43673207)x3 copy number gain See cases [RCV000137249] Chr8:12182421..43673207 [GRCh38]
Chr8:12039930..43528350 [GRCh37]
Chr8:12077339..43647507 [NCBI36]
Chr8:8p23.1-11.1
pathogenic
GRCh38/hg38 8p23.1-12(chr8:12698495-35476082)x3 copy number gain See cases [RCV000138058] Chr8:12698495..35476082 [GRCh38]
Chr8:12556004..35333600 [GRCh37]
Chr8:12600375..35453142 [NCBI36]
Chr8:8p23.1-12
pathogenic
GRCh38/hg38 8p21.2-12(chr8:25171103-31750600)x1 copy number loss See cases [RCV000138081] Chr8:25171103..31750600 [GRCh38]
Chr8:25028618..31608116 [GRCh37]
Chr8:25084535..31727658 [NCBI36]
Chr8:8p21.2-12
pathogenic
GRCh38/hg38 8p23.3-11.23(chr8:226452-38021728)x3 copy number gain See cases [RCV000137807] Chr8:226452..38021728 [GRCh38]
Chr8:176452..37879246 [GRCh37]
Chr8:166452..37998403 [NCBI36]
Chr8:8p23.3-11.23
pathogenic|likely pathogenic
GRCh38/hg38 8p23.3-12(chr8:241605-31091074)x3 copy number gain See cases [RCV000138831] Chr8:241605..31091074 [GRCh38]
Chr8:191605..30948590 [GRCh37]
Chr8:181605..31068132 [NCBI36]
Chr8:8p23.3-12
pathogenic
GRCh38/hg38 8p23.1-21.1(chr8:12382844-28625564)x3 copy number gain See cases [RCV000138244] Chr8:12382844..28625564 [GRCh38]
Chr8:12240353..28483081 [GRCh37]
Chr8:12284724..28539000 [NCBI36]
Chr8:8p23.1-21.1
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.1-11.22(chr8:7141697-38695546)x3 copy number gain See cases [RCV000139891] Chr8:7141697..38695546 [GRCh38]
Chr8:6999219..38553064 [GRCh37]
Chr8:6986629..38672221 [NCBI36]
Chr8:8p23.1-11.22
pathogenic
GRCh38/hg38 8p23.1-11.22(chr8:12729023-39235934)x3 copy number gain See cases [RCV000139770] Chr8:12729023..39235934 [GRCh38]
Chr8:12586532..39093453 [GRCh37]
Chr8:12630903..39212610 [NCBI36]
Chr8:8p23.1-11.22
pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12646123-43686843)x3 copy number gain See cases [RCV000139796] Chr8:12646123..43686843 [GRCh38]
Chr8:12503632..43541986 [GRCh37]
Chr8:12548003..43661143 [NCBI36]
Chr8:8p23.1-11.1
pathogenic
GRCh38/hg38 8p23.1-11.23(chr8:11851113-37216333)x3 copy number gain See cases [RCV000139549] Chr8:11851113..37216333 [GRCh38]
Chr8:11708622..37073851 [GRCh37]
Chr8:11746031..37193009 [NCBI36]
Chr8:8p23.1-11.23
pathogenic
GRCh38/hg38 8p23.3-12(chr8:226452-34491890)x3 copy number gain See cases [RCV000141410] Chr8:226452..34491890 [GRCh38]
Chr8:176452..34349408 [GRCh37]
Chr8:166452..34468950 [NCBI36]
Chr8:8p23.3-12
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.1-12(chr8:12383584-29033946)x1 copy number loss See cases [RCV000142516] Chr8:12383584..29033946 [GRCh38]
Chr8:12241093..28891463 [GRCh37]
Chr8:12285464..28947382 [NCBI36]
Chr8:8p23.1-12
pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p22-12(chr8:18972996-33619264)x1 copy number loss See cases [RCV000142747] Chr8:18972996..33619264 [GRCh38]
Chr8:18830506..33476782 [GRCh37]
Chr8:18874786..33596324 [NCBI36]
Chr8:8p22-12
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.1-11.21(chr8:12633490-40685533)x3 copy number gain See cases [RCV000143508] Chr8:12633490..40685533 [GRCh38]
Chr8:12490999..40543052 [GRCh37]
Chr8:12535370..40662209 [NCBI36]
Chr8:8p23.1-11.21
pathogenic
GRCh38/hg38 8p23.1-11.21(chr8:12609975-42085703)x3 copy number gain See cases [RCV000148249] Chr8:12609975..42085703 [GRCh38]
Chr8:12467484..41943221 [GRCh37]
Chr8:12511855..42062378 [NCBI36]
Chr8:8p23.1-11.21
pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12728904-43673207)x3 copy number gain See cases [RCV000148237] Chr8:12728904..43673207 [GRCh38]
Chr8:12586413..43528350 [GRCh37]
Chr8:12630784..43647507 [NCBI36]
Chr8:8p23.1-11.1
pathogenic
GRCh37/hg19 8p21.3-12(chr8:20478546-28986438)x3 copy number gain See cases [RCV000203434] Chr8:20478546..28986438 [GRCh37]
Chr8:8p21.3-12
pathogenic
GRCh37/hg19 8p23.1-11.22(chr8:12528482-39593802)x3 copy number gain See cases [RCV000511325] Chr8:12528482..39593802 [GRCh37]
Chr8:8p23.1-11.22
pathogenic
NM_006228.5(PNOC):c.232G>A (p.Glu78Lys) single nucleotide variant not specified [RCV004309636] Chr8:28339145 [GRCh38]
Chr8:28196662 [GRCh37]
Chr8:8p21.1
uncertain significance
GRCh37/hg19 8p23.3-12(chr8:158048-30262760)x3 copy number gain See cases [RCV000449225] Chr8:158048..30262760 [GRCh37]
Chr8:8p23.3-12
pathogenic
GRCh37/hg19 8p21.2-q12.1(chr8:24772064-24813176)x3 copy number gain See cases [RCV000446588] Chr8:24772064..24813176 [GRCh37]
Chr8:8p21.2-q12.1
uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3 copy number gain See cases [RCV000447507] Chr8:158991..146280828 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-11.1(chr8:158048-43786723)x3 copy number gain See cases [RCV000447909] Chr8:158048..43786723 [GRCh37]
Chr8:8p23.3-11.1
pathogenic
GRCh37/hg19 8p23.1-11.1(chr8:12580132-43388233)x3 copy number gain See cases [RCV000447913] Chr8:12580132..43388233 [GRCh37]
Chr8:8p23.1-11.1
pathogenic
GRCh37/hg19 8p21.2-12(chr8:24514488-34808438) copy number gain See cases [RCV000448582] Chr8:24514488..34808438 [GRCh37]
Chr8:8p21.2-12
pathogenic
GRCh37/hg19 8p21.1-12(chr8:27501662-29342607)x3 copy number gain See cases [RCV000510519] Chr8:27501662..29342607 [GRCh37]
Chr8:8p21.1-12
uncertain significance
GRCh37/hg19 8p22-12(chr8:16992973-32612724)x1 copy number loss not provided [RCV000509389] Chr8:16992973..32612724 [GRCh37]
Chr8:8p22-12
not provided
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771) copy number gain See cases [RCV000510234] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.1-12(chr8:12528482-33684786)x3 copy number gain See cases [RCV000510571] Chr8:12528482..33684786 [GRCh37]
Chr8:8p23.1-12
pathogenic
GRCh37/hg19 8p23.1-11.1(chr8:11935023-43824035)x3 copy number gain See cases [RCV000511028] Chr8:11935023..43824035 [GRCh37]
Chr8:8p23.1-11.1
pathogenic
GRCh37/hg19 8p23.1-12(chr8:11945855-34875355)x3 copy number gain See cases [RCV000510899] Chr8:11945855..34875355 [GRCh37]
Chr8:8p23.1-12
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3 copy number gain See cases [RCV000511095] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
NM_006228.5(PNOC):c.322C>A (p.Gln108Lys) single nucleotide variant not specified [RCV004282566] Chr8:28339235 [GRCh38]
Chr8:28196752 [GRCh37]
Chr8:8p21.1
uncertain significance
NM_006228.5(PNOC):c.500G>A (p.Arg167Gln) single nucleotide variant not specified [RCV004295304] Chr8:28339413 [GRCh38]
Chr8:28196930 [GRCh37]
Chr8:8p21.1
uncertain significance
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3 copy number gain See cases [RCV000512169] Chr8:12490999..146295771 [GRCh37]
Chr8:8p23.1-q24.3
pathogenic
GRCh37/hg19 8p23.1-12(chr8:12552775-35935825)x3 copy number gain not provided [RCV000683043] Chr8:12552775..35935825 [GRCh37]
Chr8:8p23.1-12
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3 copy number gain not provided [RCV000747254] Chr8:164984..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3 copy number gain not provided [RCV000747248] Chr8:10213..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.1-12(chr8:12556004-34374150)x3 copy number gain not provided [RCV000762735] Chr8:12556004..34374150 [GRCh37]
Chr8:8p23.1-12
likely pathogenic
NM_006228.5(PNOC):c.402C>T (p.Thr134=) single nucleotide variant not provided [RCV000879289] Chr8:28339315 [GRCh38]
Chr8:28196832 [GRCh37]
Chr8:8p21.1
benign
Single allele duplication not provided [RCV000768452] Chr8:12546855..35816855 [GRCh37]
Chr8:8p23.1-12
likely pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not provided [RCV000848478] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
NM_006228.5(PNOC):c.334G>A (p.Glu112Lys) single nucleotide variant not specified [RCV004306949] Chr8:28339247 [GRCh38]
Chr8:28196764 [GRCh37]
Chr8:8p21.1
uncertain significance
GRCh37/hg19 8p21.2-11.22(chr8:26808969-38346383)x1 copy number loss not provided [RCV002472596] Chr8:26808969..38346383 [GRCh37]
Chr8:8p21.2-11.22
pathogenic
GRCh37/hg19 8p21.2-21.1(chr8:24305969-28673405)x1 copy number loss not provided [RCV001006090] Chr8:24305969..28673405 [GRCh37]
Chr8:8p21.2-21.1
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771) copy number gain Polydactyly [RCV002280629] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.1-12(chr8:12528482-29886483)x3 copy number gain not provided [RCV001260030] Chr8:12528482..29886483 [GRCh37]
Chr8:8p23.1-12
likely pathogenic
NC_000008.10:g.(?_27319146)_(28608383_?)dup duplication Autosomal dominant nocturnal frontal lobe epilepsy [RCV003107941]|not provided [RCV002043387] Chr8:27319146..28608383 [GRCh37]
Chr8:8p21.2-21.1
uncertain significance|no classifications from unflagged records
GRCh37/hg19 8p23.3-12(chr8:158048-30187456)x1 copy number loss See cases [RCV002286343] Chr8:158048..30187456 [GRCh37]
Chr8:8p23.3-12
pathogenic
Single allele complex See cases [RCV002292428] Chr8:6999114..11935023 [GRCh37]
Chr8:8p23.3-11.21
pathogenic
Single allele complex 8p inverted duplication/deletion syndrome [RCV002280753] Chr8:158048..43019304 [GRCh37]
Chr8:8p23.3-11.21
pathogenic
NM_006228.5(PNOC):c.472G>A (p.Val158Ile) single nucleotide variant not specified [RCV004309210] Chr8:28339385 [GRCh38]
Chr8:28196902 [GRCh37]
Chr8:8p21.1
uncertain significance
GRCh37/hg19 8p21.2-12(chr8:27064033-28832392)x3 copy number gain not provided [RCV002472907] Chr8:27064033..28832392 [GRCh37]
Chr8:8p21.2-12
uncertain significance
NM_006228.5(PNOC):c.242C>T (p.Ala81Val) single nucleotide variant not specified [RCV004127879] Chr8:28339155 [GRCh38]
Chr8:28196672 [GRCh37]
Chr8:8p21.1
uncertain significance
NM_006228.5(PNOC):c.521G>C (p.Gly174Ala) single nucleotide variant not specified [RCV004106478] Chr8:28339434 [GRCh38]
Chr8:28196951 [GRCh37]
Chr8:8p21.1
uncertain significance
NM_006228.5(PNOC):c.375G>C (p.Gln125His) single nucleotide variant not specified [RCV004188951] Chr8:28339288 [GRCh38]
Chr8:28196805 [GRCh37]
Chr8:8p21.1
uncertain significance
NM_006228.5(PNOC):c.80C>T (p.Thr27Ile) single nucleotide variant not specified [RCV004134588] Chr8:28329237 [GRCh38]
Chr8:28186754 [GRCh37]
Chr8:8p21.1
uncertain significance
NM_006228.5(PNOC):c.165C>A (p.Ser55Arg) single nucleotide variant not specified [RCV004069451] Chr8:28339078 [GRCh38]
Chr8:28196595 [GRCh37]
Chr8:8p21.1
uncertain significance
NM_006228.5(PNOC):c.184A>G (p.Thr62Ala) single nucleotide variant not specified [RCV004108862] Chr8:28339097 [GRCh38]
Chr8:28196614 [GRCh37]
Chr8:8p21.1
uncertain significance
GRCh38/hg38 8p23.1-12(chr8:12721809-30183737)x1 copy number loss Microcephaly [RCV003327707] Chr8:12721809..30183737 [GRCh38]
Chr8:8p23.1-12
pathogenic
Single allele duplication not provided [RCV003448693] Chr8:12530550..43483193 [GRCh37]
Chr8:8p23.1-11.1
pathogenic
GRCh37/hg19 8p23.2-11.21(chr8:2201405-41723095)x3 copy number gain not provided [RCV003484713] Chr8:2201405..41723095 [GRCh37]
Chr8:8p23.2-11.21
pathogenic
GRCh37/hg19 8p23.1-11.23(chr8:11945856-37902453)x3 copy number gain not provided [RCV003484722] Chr8:11945856..37902453 [GRCh37]
Chr8:8p23.1-11.23
pathogenic
GRCh37/hg19 8p23.1-11.22(chr8:12560782-38748763)x3 copy number gain not provided [RCV003484724] Chr8:12560782..38748763 [GRCh37]
Chr8:8p23.1-11.22
pathogenic
GRCh37/hg19 8p22-11.1(chr8:14240573-43824035)x3 copy number gain not provided [RCV003484725] Chr8:14240573..43824035 [GRCh37]
Chr8:8p22-11.1
pathogenic
NM_006228.5(PNOC):c.305G>A (p.Arg102Gln) single nucleotide variant not specified [RCV004509820] Chr8:28339218 [GRCh38]
Chr8:28196735 [GRCh37]
Chr8:8p21.1
uncertain significance
NM_006228.5(PNOC):c.299G>A (p.Arg100Gln) single nucleotide variant not specified [RCV004509819] Chr8:28339212 [GRCh38]
Chr8:28196729 [GRCh37]
Chr8:8p21.1
uncertain significance
NM_006228.5(PNOC):c.218G>A (p.Ser73Asn) single nucleotide variant not specified [RCV004509818] Chr8:28339131 [GRCh38]
Chr8:28196648 [GRCh37]
Chr8:8p21.1
uncertain significance
GRCh37/hg19 8p21.2-12(chr8:23754939-30219110)x1 copy number loss not specified [RCV003986748] Chr8:23754939..30219110 [GRCh37]
Chr8:8p21.2-12
pathogenic
GRCh37/hg19 8p21.2-q21.3(chr8:27024288-89410121)x3 copy number gain not specified [RCV003986754] Chr8:27024288..89410121 [GRCh37]
Chr8:8p21.2-q21.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not specified [RCV003986742] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-11.21(chr8:158048-41600696)x3 copy number gain not specified [RCV003986756] Chr8:158048..41600696 [GRCh37]
Chr8:8p23.3-11.21
pathogenic
GRCh37/hg19 8p21.3-11.1(chr8:20136266-43786723)x3 copy number gain not specified [RCV003986767] Chr8:20136266..43786723 [GRCh37]
Chr8:8p21.3-11.1
pathogenic
NM_006228.5(PNOC):c.471G>C (p.Leu157Phe) single nucleotide variant not specified [RCV004509821] Chr8:28339384 [GRCh38]
Chr8:28196901 [GRCh37]
Chr8:8p21.1
uncertain significance
NM_006228.5(PNOC):c.328G>A (p.Glu110Lys) single nucleotide variant not specified [RCV004653567] Chr8:28339241 [GRCh38]
Chr8:28196758 [GRCh37]
Chr8:8p21.1
uncertain significance
NM_006228.5(PNOC):c.161C>G (p.Pro54Arg) single nucleotide variant not specified [RCV004653568] Chr8:28339074 [GRCh38]
Chr8:28196591 [GRCh37]
Chr8:8p21.1
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1057
Count of miRNA genes:523
Interacting mature miRNAs:583
Transcripts:ENST00000301908, ENST00000518479, ENST00000519592, ENST00000522209
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407054595GWAS703571_Hbody mass index QTL GWAS703571 (human)5e-09body mass indexbody mass index (BMI) (CMO:0000105)82833378928333790Human
1298482BP2_HBlood pressure QTL 2 (human)1.8Blood pressurediastolic8695325632953256Human
406996181GWAS645157_Hdaytime rest measurement QTL GWAS645157 (human)2e-12daytime rest measurement82833378928333790Human
1558703SCL6_HSerum cholesterol level QTL 1 (human)1.2Lipid levelHDL cholesterol81246863538468635Human
407125677GWAS774653_Hserum IgG glycosylation measurement QTL GWAS774653 (human)0.000009serum IgG glycosylation measurement82832423828324239Human

Markers in Region
D8S1809  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37828,191,474 - 28,191,645UniSTSGRCh37
Build 36828,247,393 - 28,247,564RGDNCBI36
Celera827,151,340 - 27,151,499RGD
Cytogenetic Map8p21UniSTS
HuRef826,736,769 - 26,736,940UniSTS
Marshfield Genetic Map854.98RGD
Marshfield Genetic Map854.98UniSTS
Genethon Genetic Map854.2UniSTS
deCODE Assembly Map847.81UniSTS
Whitehead-YAC Contig Map8 UniSTS
SHGC-110036  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37828,199,074 - 28,199,408UniSTSGRCh37
Build 36828,254,993 - 28,255,327RGDNCBI36
Celera827,158,928 - 27,159,262RGD
Cytogenetic Map8p21UniSTS
HuRef826,744,370 - 26,744,704UniSTS
TNG Radiation Hybrid Map813642.0UniSTS
STS-U48263  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37828,200,579 - 28,200,789UniSTSGRCh37
Build 36828,256,498 - 28,256,708RGDNCBI36
Celera827,160,431 - 27,160,641RGD
Cytogenetic Map8p21UniSTS
HuRef826,745,875 - 26,746,085UniSTS
GeneMap99-GB4 RH Map8108.79UniSTS
NCBI RH Map8339.8UniSTS
PNOC  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37828,196,687 - 28,196,871UniSTSGRCh37
Build 36828,252,606 - 28,252,790RGDNCBI36
Celera827,156,541 - 27,156,725RGD
HuRef826,741,983 - 26,742,167UniSTS
WI-18480  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37828,200,738 - 28,200,864UniSTSGRCh37
Build 36828,256,657 - 28,256,783RGDNCBI36
Celera827,160,590 - 27,160,716RGD
Cytogenetic Map8p21UniSTS
HuRef826,746,034 - 26,746,160UniSTS
GeneMap99-GB4 RH Map8107.49UniSTS
Whitehead-RH Map8112.0UniSTS
NCBI RH Map8339.8UniSTS
WI-15701  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37828,200,728 - 28,200,852UniSTSGRCh37
Build 36828,256,647 - 28,256,771RGDNCBI36
Celera827,160,580 - 27,160,704RGD
Cytogenetic Map8p21UniSTS
HuRef826,746,024 - 26,746,148UniSTS
GeneMap99-GB4 RH Map8108.5UniSTS
Whitehead-RH Map8114.0UniSTS
NCBI RH Map8339.8UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
767 2071 1115 1114 3763 1167 1731 1 472 1881 313 1096 4792 4424 34 3182 1 600 1353 1221 162

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001284244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_006228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005273532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011544559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017013578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054360695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054360696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC021678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK289633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY011845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY335948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC034758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF976583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT019334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA412176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA403369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM759608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U48263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X97367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X97370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000301908   ⟹   ENSP00000301908
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl828,317,268 - 28,343,351 (+)Ensembl
Ensembl Acc Id: ENST00000518479   ⟹   ENSP00000428059
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl828,316,986 - 28,339,376 (+)Ensembl
Ensembl Acc Id: ENST00000519592
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl828,338,648 - 28,340,208 (+)Ensembl
Ensembl Acc Id: ENST00000522209   ⟹   ENSP00000430145
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl828,338,648 - 28,343,355 (+)Ensembl
RefSeq Acc Id: NM_001284244   ⟹   NP_001271173
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38828,338,647 - 28,343,351 (+)NCBI
HuRef826,719,942 - 26,746,168 (+)NCBI
CHM1_1828,398,130 - 28,402,837 (+)NCBI
T2T-CHM13v2.0828,616,817 - 28,621,518 (+)NCBI
Sequence:
RefSeq Acc Id: NM_006228   ⟹   NP_006219
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38828,317,268 - 28,343,351 (+)NCBI
GRCh37828,174,562 - 28,200,872 (+)NCBI
Build 36828,230,568 - 28,256,787 (+)NCBI Archive
HuRef826,719,942 - 26,746,168 (+)NCBI
CHM1_1828,376,658 - 28,402,837 (+)NCBI
T2T-CHM13v2.0828,595,445 - 28,621,518 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005273532   ⟹   XP_005273589
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38828,317,268 - 28,343,351 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011544559   ⟹   XP_011542861
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38828,316,988 - 28,343,351 (+)NCBI
Sequence:
RefSeq Acc Id: XM_054360695   ⟹   XP_054216670
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0828,595,445 - 28,621,518 (+)NCBI
RefSeq Acc Id: XM_054360696   ⟹   XP_054216671
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0828,595,062 - 28,621,518 (+)NCBI
RefSeq Acc Id: NP_006219   ⟸   NM_006228
- Peptide Label: isoform 1 preproprotein
- UniProtKB: B7Z749 (UniProtKB/Swiss-Prot),   Q6FH16 (UniProtKB/Swiss-Prot),   Q13519 (UniProtKB/Swiss-Prot),   A8K0R8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005273589   ⟸   XM_005273532
- Peptide Label: isoform X1
- UniProtKB: A8K0R8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001271173   ⟸   NM_001284244
- Peptide Label: isoform 2
- UniProtKB: Q13519 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011542861   ⟸   XM_011544559
- Peptide Label: isoform X1
- UniProtKB: A8K0R8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000428059   ⟸   ENST00000518479
Ensembl Acc Id: ENSP00000430145   ⟸   ENST00000522209
Ensembl Acc Id: ENSP00000301908   ⟸   ENST00000301908
RefSeq Acc Id: XP_054216671   ⟸   XM_054360696
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054216670   ⟸   XM_054360695
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q13519-F1-model_v2 AlphaFold Q13519 1-176 view protein structure

Promoters
RGD ID:6806945
Promoter ID:HG_KWN:61015
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid
Transcripts:OTTHUMT00000219964,   UC010LVA.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36828,230,071 - 28,230,732 (+)MPROMDB
RGD ID:7212979
Promoter ID:EPDNEW_H12235
Type:single initiation site
Name:PNOC_1
Description:prepronociceptin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38828,317,269 - 28,317,329EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9163 AgrOrtholog
COSMIC PNOC COSMIC
Ensembl Genes ENSG00000168081 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000301908 ENTREZGENE
  ENST00000301908.8 UniProtKB/Swiss-Prot
  ENST00000518479.5 UniProtKB/TrEMBL
  ENST00000522209 ENTREZGENE
  ENST00000522209.1 UniProtKB/Swiss-Prot
GTEx ENSG00000168081 GTEx
HGNC ID HGNC:9163 ENTREZGENE
Human Proteome Map PNOC Human Proteome Map
InterPro Nociceptin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Opioid_neupept UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5368 UniProtKB/Swiss-Prot
NCBI Gene 5368 ENTREZGENE
OMIM 601459 OMIM
PANTHER PREPRONOCICEPTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11438 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Opiods_neuropep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA33485 PharmGKB
PRINTS OPIOIDPRCRSR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ORPHNNPRCRSR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE OPIOIDS_PRECURSOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
UniProt A8K0R8 ENTREZGENE, UniProtKB/TrEMBL
  B7Z749 ENTREZGENE
  E7EVP0_HUMAN UniProtKB/TrEMBL
  PNOC_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q6FH16 ENTREZGENE
  Q9BYY3_HUMAN UniProtKB/TrEMBL
UniProt Secondary B7Z749 UniProtKB/Swiss-Prot
  Q6FH16 UniProtKB/Swiss-Prot