Agrp (agouti related neuropeptide)

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Gene: Agrp (agouti related neuropeptide) Mus musculus

Analyze

Symbol:

Agrp

Name:

agouti related neuropeptide

RGD ID:

733559

MGI Page

MGI

Description:

Enables neuropeptide hormone activity. Acts upstream of or within adult feeding behavior and neuropeptide signaling pathway. Predicted to be located in Golgi lumen and neuronal cell body. Predicted to be active in extracellular space. Is expressed in adrenal gland; brain; genitourinary system; lung; and spleen. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human AGRP (agouti related neuropeptide).

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

Ag; agouti-related protein; Agrt; Art; orexigenic neuropeptide

RGD Orthologs

Human

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	AGRP (agouti related neuropeptide)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Agrp (agouti related neuropeptide)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Agrp (agouti related neuropeptide)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	AGRP (agouti related neuropeptide)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	AGRP (agouti related neuropeptide)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Agrp (agouti related neuropeptide)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	AGRP (agouti related neuropeptide)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	AGRP (agouti related neuropeptide)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Agrp (agouti related neuropeptide)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Agrp (agouti related neuropeptide)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	AGRP (agouti related neuropeptide)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	agrp (agouti related neuropeptide)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid\|ZFIN)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	106,293,327 - 106,306,477 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	106,293,330 - 106,364,025 (-)	Ensembl		GRCm39 Ensembl
GRCm38	8	105,566,695 - 105,579,845 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	105,566,698 - 105,637,393 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	108,090,598 - 108,092,198 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	108,455,827 - 108,457,427 (-)	NCBI		MGSCv36	mm8
Celera	8	109,789,930 - 109,791,530 (-)	NCBI		Celera
Cytogenetic Map	8	D3	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant dyskeratosis congenita 6 (ISO)

genetic disease (ISO)

Hyperphagia (ISO)

obesity (ISO)

Thinness (ISO)

type 2 diabetes mellitus (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3',4,4',5-Pentachlorobiphenyl (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-deoxy-D-glucose (ISO)

4,4'-sulfonyldiphenol (EXP)

acadesine (EXP)

actinomycin D (EXP)

AM-251 (ISO)

ammonium chloride (ISO)

arachidonyl-2'-chloroethylamide (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

camptothecin (ISO)

carbon nanotube (EXP)

cerulenin (EXP)

chloroprene (EXP)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

diclofenac (ISO)

dimethyl sulfoxide (ISO)

diprotium oxide (ISO)

graphite (ISO)

metformin (EXP)

methylmercury chloride (EXP)

monosodium L-glutamate (ISO)

morphine (EXP)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (EXP)

olanzapine (EXP,ISO)

ozone (EXP)

potassium dichromate (EXP)

ruthenium red (EXP)

sodium arsenite (EXP)

streptozocin (ISO)

tetraphene (EXP)

triphenyl phosphate (EXP)

water (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adult feeding behavior (IBA,IDA,ISO)

circadian rhythm (ISO)

eating behavior (ISO)

hormone-mediated signaling pathway (IEA)

long-day photoperiodism (ISO)

maternal process involved in female pregnancy (ISO)

neuropeptide signaling pathway (IBA,IDA,ISO)

positive regulation of feeding behavior (IBA,ISO)

regulation of feeding behavior (ISO)

response to insulin (ISO)

Cellular Component

extracellular region (IEA,TAS)

extracellular space (IBA,ISO)

Golgi apparatus (IEA)

Golgi lumen (ISO)

neuronal cell body (ISO)

Molecular Function

neuropeptide hormone activity (IBA,IDA,ISO)

signaling receptor binding (IEA)

type 1 melanocortin receptor binding (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

altered melanocortin system pathway (ISO)

melanocortin system pathway (ISO)

obesity pathway (TAS)

syndecan signaling pathway (ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal blood homeostasis (IAGP)

abnormal eating behavior (IAGP)

abnormal energy expenditure (IAGP)

abnormal food intake (IAGP)

abnormal induced morbidity/mortality (IAGP)

abnormal inhibitory postsynaptic currents (IAGP)

abnormal liver physiology (IAGP)

abnormal postnatal growth/weight/body size (IAGP)

decreased body temperature (IAGP)

decreased body weight (IAGP)

decreased cholesterol level (IAGP)

decreased circulating ketone body level (IAGP)

decreased circulating leptin level (IAGP)

decreased circulating VLDL triglyceride level (IAGP)

decreased food intake (IAGP)

decreased lean body mass (IAGP)

decreased liver triglyceride level (IAGP)

decreased neuron number (IAGP)

decreased respiratory quotient (IAGP)

decreased serotonin level (IAGP)

decreased susceptibility to diet-induced obesity (IAGP)

decreased total body fat amount (IAGP)

enhanced fertility (IAGP)

extended life span (IAGP)

hyperactivity (IAGP)

hyperdipsia (IAGP)

impaired adaptive thermogenesis (IAGP)

improved glucose tolerance (IAGP)

increased body weight (IAGP)

increased circulating thyroxine level (IAGP)

increased circulating triiodothyronine level (IAGP)

increased core body temperature (IAGP)

increased epididymal fat pad weight (IAGP)

increased food intake (IAGP)

increased locomotor activity (IAGP)

increased mesenteric fat pad weight (IAGP)

increased noradrenaline level (IAGP)

increased oxygen consumption (IAGP)

increased renal fat pad weight (IAGP)

increased sensitivity to induced morbidity/mortality (IAGP)

increased susceptibility to weight loss (IAGP)

increased total body fat amount (IAGP)

no abnormal phenotype detected (IAGP)

obese (IAGP)

weight loss (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	A polymorphism in the human agouti-related protein is associated with late-onset obesity.	Argyropoulos G, etal., J Clin Endocrinol Metab. 2002 Sep;87(9):4198-202.
2.	The genetic association database.	Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
3.	Reduced expression of the KATP channel subunit, Kir6.2, is associated with decreased expression of neuropeptide Y and agouti-related protein in the hypothalami of Zucker diabetic fatty rats.	Gyte A, etal., J Neuroendocrinol. 2007 Dec;19(12):941-51.
4.	Plasma levels of agouti-related protein are increased in obese men.	Katsuki A, etal., J Clin Endocrinol Metab 2001 May;86(5):1921-4.
5.	A role for the Agouti-Related Protein promoter in obesity and type 2 diabetes.	Mayfield DK, etal., Biochem Biophys Res Commun. 2001 Sep 21;287(2):568-73.
6.	Electronic Transfer of Homolog Data	MGD and Homologene mouse data transfer
7.	MGDs mouse GO annotations	MGD data from the GO Consortium
8.	MGD IEA	MGD IEA
9.	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
10.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
11.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12.	Agouti-related protein is a mediator of diabetic hyperphagia.	Qu SY, etal., Regul Pept. 2001 Apr 2;98(1-2):69-75.
13.	Mouse MP Annotation Import Pipeline	RGD automated import pipeline
14.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
16.	The critical role of the melanocortin system in the control of energy balance.	Seeley RJ, etal., Annu Rev Nutr 2004;24:133-49.

Additional References at PubMed

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PMID:10771094	PMID:11042159	PMID:11076861	PMID:11078460	PMID:11137996	PMID:11217851	PMID:11340336	PMID:12006366	PMID:12077332	PMID:12443978	PMID:12477932	PMID:12851299
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PMID:16141072	PMID:16141073	PMID:16141394	PMID:16254186	PMID:16330327	PMID:16602821	PMID:16604086	PMID:16709597	PMID:16978589	PMID:17097059	PMID:17202473	PMID:17873059
PMID:17974621	PMID:17974626	PMID:18098136	PMID:18162515	PMID:18162531	PMID:18272480	PMID:18316029	PMID:18470724	PMID:18583425	PMID:18784302	PMID:18799693	PMID:19074037
PMID:19160495	PMID:19524132	PMID:19563755	PMID:19566712	PMID:19737523	PMID:19805233	PMID:20051234	PMID:20096642	PMID:20103739	PMID:20980461	PMID:21209617	PMID:21267068
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Genomics

Comparative Map Data

Agrp
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	106,293,327 - 106,306,477 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	106,293,330 - 106,364,025 (-)	Ensembl		GRCm39 Ensembl
GRCm38	8	105,566,695 - 105,579,845 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	105,566,698 - 105,637,393 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	108,090,598 - 108,092,198 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	108,455,827 - 108,457,427 (-)	NCBI		MGSCv36	mm8
Celera	8	109,789,930 - 109,791,530 (-)	NCBI		Celera
Cytogenetic Map	8	D3	NCBI

AGRP
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	67,482,571 - 67,483,547 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	16	67,482,571 - 67,483,547 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	67,516,474 - 67,517,450 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	66,073,975 - 66,075,217 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	66,073,974 - 66,074,805	NCBI
Celera	16	52,024,676 - 52,025,918 (-)	NCBI		Celera
Cytogenetic Map	16	q22.1	NCBI
HuRef	16	53,389,602 - 53,390,844 (-)	NCBI		HuRef
CHM1_1	16	68,923,856 - 68,925,098 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	16	73,277,343 - 73,278,319 (-)	NCBI		T2T-CHM13v2.0

Agrp
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	19	33,447,992 - 33,523,068 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	33,447,992 - 33,449,584 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	40,263,577 - 40,265,169 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	19	40,916,914 - 40,918,506 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	19	43,214,688 - 43,216,280 (-)	NCBI	Rnor_WKY
Rnor_6.0	19	37,525,941 - 37,584,875 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	37,526,419 - 37,528,011 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	48,391,845 - 48,406,659 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	35,386,682 - 35,388,274 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	35,391,672 - 35,392,244 (-)	NCBI
Celera	19	32,876,306 - 32,877,927 (-)	NCBI		Celera
Cytogenetic Map	19	q12	NCBI

Agrp
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955484	9,165,120 - 9,166,789 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955484	9,165,120 - 9,166,789 (+)	NCBI	ChiLan1.0	ChiLan1.0

AGRP
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	16	82,924,463 - 82,925,968 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	47,827,532 - 47,872,727 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	67,216,008 - 67,217,258 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	67,216,008 - 67,217,258 (-)	Ensembl	panpan1.1		panPan2

AGRP
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	81,924,249 - 81,926,510 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	81,925,055 - 81,925,845 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	81,914,032 - 81,915,572 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	82,359,662 - 82,361,202 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	82,360,349 - 82,361,139 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	82,185,812 - 82,187,352 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	81,866,912 - 81,868,452 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	82,510,362 - 82,511,902 (+)	NCBI		UU_Cfam_GSD_1.0

Agrp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	41,652,027 - 41,660,973 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936475	17,927,985 - 17,937,147 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936475	17,927,991 - 17,929,377 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AGRP
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	28,132,615 - 28,134,900 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	28,132,614 - 28,135,594 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	25,399,704 - 25,401,437 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

AGRP
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	59,972,728 - 59,974,728 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	59,973,922 - 59,974,660 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666047	22,722,627 - 22,723,740 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Agrp
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624746	18,826,545 - 18,827,299 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624746	18,826,206 - 18,827,453 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Agrp
279 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	124
Count of miRNA genes:	123
Interacting mature miRNAs:	124
Transcripts:	ENSMUST00000005849
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4140967	Bmd39_m	bone mineral density 39 (mouse)			Not determined		8	32506572	117965439	Mouse
1558875	Eae31_m	experimental allergic encephalomyelitis susceptibility 31 (mouse)			Not determined		8	35109930	115563747	Mouse
27226754	Femd6_m	femur midshaft diameter 6, 10 week (mouse)					8	37867154	110326632	Mouse
1357708	Orq1_m	ovulation rate QTL 1 (mouse)			Not determined		8	71740461	124622354	Mouse
4142023	W3q5_m	weight 3 weeks QTL 5 (mouse)			Not determined			71740461	124622354	Mouse
1300920	Pitm3_m	prion incubation time 3 (mouse)			Not determined		8	73929123	107929226	Mouse
27095912	Pglq14_m	pelvic girdle length QTL 14, 16 week (mouse)					8	74126628	126826739	Mouse
1558890	Lith18_m	lithogenic gene 18 (mouse)			Not determined		8	76402145	110402251	Mouse
1357470	Obq16_m	obesity QTL 16 (mouse)			Not determined		8	76411976	110412125	Mouse
10412234	Nhdlq14_m	non-HDL QTL 14 (mouse)			Not determined		8	76411976	110412125	Mouse
1301874	Hdlq16_m	HDL QTL 16 (mouse)			Not determined		8	76411976	110412125	Mouse
1301099	Cbm2_m	cerebellum weight 2 (mouse)			Not determined		8	79245241	113245331	Mouse
1301581	Char2_m	P. chabaudi malaria resistance QTL 2 (mouse)			Not determined		8	79808806	113809031	Mouse
10755530	Wbc2_m	white blood cell count 2 (mouse)					8	81819296	115819296	Mouse
10755519	Wbc1_m	white blood cell count 1 (mouse)					8	82345783	116345783	Mouse
1301766	Desp1_m	despair 1 (mouse)			Not determined		8	85486208	119486373	Mouse
1302049	Heal1_m	wound healing/regeneration 1 (mouse)			Not determined		8	86443553	120443701	Mouse
1301253	Skmw2_m	skeletal muscle weight 2 (mouse)			Not determined		8	86443553	120443701	Mouse
10045619	Heal14_m	wound healing/regeneration 14 (mouse)			Not determined		8	86443553	120443701	Mouse
27226796	Scvln16_m	sacral vertebrae length 2, 16 week (mouse)					8	89726628	130027694	Mouse
1357494	Obsty2_m	obesity 2 (mouse)			Not determined		8	96245241	129745061	Mouse
12880431	Fgf23lq2_m	FGF23 serum level QTL 2 (mouse)					8	97626632	130127694	Mouse
11252141	Fdr2_m	fat response to dietary restriction 2 (mouse)					8	98390634	130127694	Mouse
1301481	Lith11_m	lithogenic gene 11 (mouse)			Not determined		8	98563635	130127694	Mouse
1302105	Im1_m	Immunoregulatory 1 (mouse)			Not determined		8	99828531	130127694	Mouse
1301080	Sluc9_m	susceptibility to lung cancer 9 (mouse)			Not determined		8	99828531	130127694	Mouse
4141435	Fbtq3_m	femoral bone trait QTL 3 (mouse)			Not determined		8	100965309	130127694	Mouse
1300560	Tgl1_m	triglyceride level 1 (mouse)			Not determined		8	102486208	111650036	Mouse
1300681	Pgia22_m	proteoglycan induced arthritis 22 (mouse)			Not determined		8	102486208	116025457	Mouse
1301316	Dntcs1_m	dental caries susceptibility 1 (mouse)			Not determined		8	103443553	127781786	Mouse
11532691	Sluc38_m	susceptibility to lung cancer 38 (mouse)					8	105033977	130127694	Mouse
11532692	Sluc38a_m	susceptibility to lung cancer 38a (mouse)					8	105033977	130127694	Mouse

Markers in Region

RH94762

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	8	105,567,386 - 105,567,488	UniSTS	GRCm38
MGSCv37	8	108,091,286 - 108,091,388	UniSTS	GRCm37
Celera	8	109,790,618 - 109,790,720	UniSTS
Cytogenetic Map	8	D1-D2	UniSTS
Cytogenetic Map	8	D3	UniSTS

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001271806	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_007427	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC151573	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY497378	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY497379	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC079902	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466525	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CO044337	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U89484	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U89486	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSMUST00000005849 ⟹ ENSMUSP00000005849

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	8	106,293,330 - 106,294,930 (-)	Ensembl
GRCm38.p6 Ensembl	8	105,566,698 - 105,568,298 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000194091 ⟹ ENSMUSP00000142044

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	8	106,293,330 - 106,364,025 (-)	Ensembl
GRCm38.p6 Ensembl	8	105,566,698 - 105,637,393 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000194654 ⟹ ENSMUSP00000141783

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	8	106,293,430 - 106,306,477 (-)	Ensembl
GRCm38.p6 Ensembl	8	105,566,798 - 105,579,845 (-)	Ensembl

RefSeq Acc Id:

NM_001271806 ⟹ NP_001258735

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	8	106,293,327 - 106,306,477 (-)	NCBI
GRCm38	8	105,566,695 - 105,579,845 (-)	NCBI
Celera	8	109,789,927 - 109,803,342 (-)	NCBI

Sequence:

show sequence

AGCTTTGTTCCTTCTTGTCTATAGTTATTCCCCTGTCCTAGACCTTCCAGAACTGATGGGAAAC
TCTGACCAAATCCACCCCCTCCCCAAGAATGGACTGAGCATAAAGATGGCATGAGAGATGCCAT
CTTCCACCTTTGCAGCATTCCAGGCTATATAACAAAATCTGTGAGCTGGGACTGCAGACAACAC
AATGGGAGGCACCTCATGCCCTGGCTACAGGAAGCAGTCACGTGTGGACCCTTTATTAGGCACT
GCCATATAAGCTCAGGGCACAAGAGACCAGGACATCCCTAGGCAAAGATCAGCAAGCAAAGGCC
ATGCTGACTGCAATGTTGCTGAGTTGTGTTCTGCTGTTGGCACTGCCTCCCACACTGGGGGTCC
AGATGGGCGTGGCTCCACTGAAGGGCATCAGAAGGCCTGACCAGGCTCTGTTCCCAGAGTTCCC
AGGTCTAAGTCTGAATGGCCTCAAGAAGACAACTGCAGACCGAGCAGAAGAAGTTCTGCTGCAG
AAGGCAGAAGCTTTGGCGGAGGTGCTAGATCCACAGAACCGCGAGTCTCGTTCTCCGCGTCGCT
GTGTAAGGCTGCACGAGTCCTGCTTGGGACAGCAGGTACCTTGCTGCGACCCGTGCGCTACGTG
CTACTGCCGCTTCTTCAATGCCTTTTGCTACTGCCGCAAGCTGGGTACGGCCACGAACCTCTGT
AGTCGCACCTAGCCAATGGATGTTGTTTGGGCAAAGGCAGGGGATGAGAATAAAGGATGGGACG
GTTTAACCT

hide sequence

RefSeq Acc Id:

NM_007427 ⟹ NP_031453

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	8	106,293,327 - 106,294,933 (-)	NCBI
GRCm38	8	105,566,695 - 105,568,301 (-)	NCBI
MGSCv37	8	108,090,598 - 108,092,198 (-)	RGD
Celera	8	109,789,927 - 109,803,342 (-)	NCBI
cM Map	8		ENTREZGENE

Sequence:

show sequence

AGGCGGCCTGAAAGCTTTGTCCTCTGAAGCTGTATGCCCACCGGGGGAACAGTGTTTTCTGCTC
CCTTGGTTTCCAGGAACCTTAGGGAGGCACCTCATGCCCTGGCTACAGGAAGCAGTCACGTGTG
GACCCTTTATTAGGCACTGCCATATAAGCTCAGGGCACAAGAGACCAGGACATCCCTAGGCAAA
GATCAGCAAGCAAAGGCCATGCTGACTGCAATGTTGCTGAGTTGTGTTCTGCTGTTGGCACTGC
CTCCCACACTGGGGGTCCAGATGGGCGTGGCTCCACTGAAGGGCATCAGAAGGCCTGACCAGGC
TCTGTTCCCAGAGTTCCCAGGTCTAAGTCTGAATGGCCTCAAGAAGACAACTGCAGACCGAGCA
GAAGAAGTTCTGCTGCAGAAGGCAGAAGCTTTGGCGGAGGTGCTAGATCCACAGAACCGCGAGT
CTCGTTCTCCGCGTCGCTGTGTAAGGCTGCACGAGTCCTGCTTGGGACAGCAGGTACCTTGCTG
CGACCCGTGCGCTACGTGCTACTGCCGCTTCTTCAATGCCTTTTGCTACTGCCGCAAGCTGGGT
ACGGCCACGAACCTCTGTAGTCGCACCTAGCCAATGGATGTTGTTTGGGCAAAGGCAGGGGATG
AGAATAAAGGATGGGACGGTTTAACCT

hide sequence

Protein Sequences


Protein RefSeqs	NP_001258735	(Get FASTA)	NCBI Sequence Viewer
	NP_031453	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB68620	(Get FASTA)	NCBI Sequence Viewer
	AAB68622	(Get FASTA)	NCBI Sequence Viewer
	AAH79902	(Get FASTA)	NCBI Sequence Viewer
	AAS77295	(Get FASTA)	NCBI Sequence Viewer
	EDL11287	(Get FASTA)	NCBI Sequence Viewer
	P56473	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_031453 ⟸ NM_007427
- Peptide Label:	precursor
- UniProtKB:	O35967 (UniProtKB/Swiss-Prot), P56473 (UniProtKB/Swiss-Prot), Q3UU47 (UniProtKB/TrEMBL), A0A8C6HDU6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLTAMLLSCVLLLALPPTLGVQMGVAPLKGIRRPDQALFPEFPGLSLNGLKKTTADRAEEVLLQ KAEALAEVLDPQNRESRSPRRCVRLHESCLGQQVPCCDPCATCYCRFFNAFCYCRKLGTATNLC SRT hide sequence

RefSeq Acc Id:	NP_001258735 ⟸ NM_001271806
- Peptide Label:	precursor
- UniProtKB:	O35967 (UniProtKB/Swiss-Prot), P56473 (UniProtKB/Swiss-Prot), Q3UU47 (UniProtKB/TrEMBL), A0A8C6HDU6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLTAMLLSCVLLLALPPTLGVQMGVAPLKGIRRPDQALFPEFPGLSLNGLKKTTADRAEEVLLQ KAEALAEVLDPQNRESRSPRRCVRLHESCLGQQVPCCDPCATCYCRFFNAFCYCRKLGTATNLC SRT hide sequence

RefSeq Acc Id:

ENSMUSP00000142044 ⟸ ENSMUST00000194091

RefSeq Acc Id:

ENSMUSP00000005849 ⟸ ENSMUST00000005849

RefSeq Acc Id:

ENSMUSP00000141783 ⟸ ENSMUST00000194654

Protein Domains

Agouti

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P56473-F1-model_v2	AlphaFold	P56473	1-131	view protein structure

Promoters

RGD ID:

8668101

Promoter ID:

EPDNEW_M12081

Type:

initiation region

Name:

Agrp_2

Description:

Mus musculus agouti related neuropeptide , transcript variant1, mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_M12082

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	8	105,579,860 - 105,579,920	EPDNEW

RGD ID:

8668103

Promoter ID:

EPDNEW_M12082

Type:

single initiation site

Name:

Agrp_1

Description:

Mus musculus agouti related neuropeptide , transcript variant1, mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_M12081

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	8	105,586,228 - 105,586,288	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:892013	AgrOrtholog
Ensembl Genes	ENSMUSG00000005705	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSMUSP00000005849	ENTREZGENE
	ENSMUSP00000005849.6	UniProtKB/Swiss-Prot
	ENSMUSP00000141783	ENTREZGENE
	ENSMUSP00000141783.2	UniProtKB/TrEMBL
	ENSMUSP00000142044.2	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSMUST00000005849	ENTREZGENE
	ENSMUST00000005849.11	UniProtKB/Swiss-Prot
	ENSMUST00000194091.6	UniProtKB/Swiss-Prot
	ENSMUST00000194654	ENTREZGENE
	ENSMUST00000194654.2	UniProtKB/TrEMBL
Gene3D-CATH	4.10.760.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Agouti	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Agouti_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Agouti_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:11604	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD	MGI:892013	ENTREZGENE
NCBI Gene	11604	ENTREZGENE
PANTHER	AGOUTI-RELATED PROTEIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR16551	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Agouti	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Agrp	PhenoGen
PROSITE	AGOUTI_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	AGOUTI_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	Agouti	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF57055	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0A6YX09_MOUSE	UniProtKB/TrEMBL
	A0A8C6HDU6	ENTREZGENE
	AGRP_MOUSE	UniProtKB/Swiss-Prot
	O35967	ENTREZGENE
	P56473	ENTREZGENE
	Q3UU47	ENTREZGENE, UniProtKB/TrEMBL
	Q5J6B1_MOUSE	UniProtKB/TrEMBL
UniProt Secondary	O35967	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-01-27	Agrp	agouti related neuropeptide		agouti related protein	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - GAD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)

Mammalian Phenotype

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - GAD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)

Mammalian Phenotype