Flt4 (FMS-like tyrosine kinase 4) - Rat Genome Database

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Gene: Flt4 (FMS-like tyrosine kinase 4) Mus musculus
Analyze
Symbol: Flt4
Name: FMS-like tyrosine kinase 4
RGD ID: 733489
MGI Page MGI
Description: Enables vascular endothelial growth factor receptor activity. Involved in lymphangiogenesis; regulation of blood vessel remodeling; and sprouting angiogenesis. Acts upstream of or within lung alveolus development; positive regulation of cell population proliferation; and respiratory system process. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; extraembryonic component; and genitourinary system. Used to study hereditary lymphedema. Human ortholog(s) of this gene implicated in hereditary lymphedema IA. Orthologous to human FLT4 (fms related receptor tyrosine kinase 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI323512; Chy; chylous ascites; Flt-; Flt-4; receptor protein tyrosine kinase; tyrosine-protein kinase receptor FLT4; vascular endothelial growth factor receptor 3; vascular endothelial growth factor receptor-3; VEGF; VEGFR; VEGFR-3; VEGFR3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391149,500,506 - 49,543,566 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1149,500,090 - 49,543,566 (+)EnsemblGRCm39 Ensembl
GRCm381149,609,679 - 49,652,739 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1149,609,263 - 49,652,739 (+)EnsemblGRCm38mm10GRCm38
MGSCv371149,423,181 - 49,466,241 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361149,453,150 - 49,495,652 (+)NCBIMGSCv36mm8
Celera1154,171,357 - 54,214,402 (+)NCBICelera
Cytogenetic Map11B1.2NCBI
cM Map1129.69NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (ISO)
membrane  (IEA)
nucleoplasm  (ISO)
nucleus  (IEA)
plasma membrane  (IBA,ISO)
receptor complex  (IBA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Meta-analysis of contribution of genetic polymorphisms in drug-metabolizing enzymes or transporters to axitinib pharmacokinetics. Brennan M, etal., Eur J Clin Pharmacol. 2012 May;68(5):645-55. Epub 2011 Dec 15.
2. Expression pattern of VEGFR-1, -2, -3 and D2-40 protein in the skin of patients with systemic sclerosis. Higashi-Kuwata N, etal., Eur J Dermatol. 2011 Jul-Aug;21(4):490-4. doi: 10.1684/ejd.2011.1284.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Elevated expression of VEGFR-3 in lymphatic endothelial cells from lymphangiomas. Norgall S, etal., BMC Cancer. 2007 Jun 21;7:105.
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Nine Genes Mediate the Therapeutic Effects of Iodine-131 Radiotherapy in Thyroid Carcinoma Patients. Shuwen H, etal., Dis Markers. 2020 Jun 16;2020:9369341. doi: 10.1155/2020/9369341. eCollection 2020.
Additional References at PubMed
PMID:1319394   PMID:7596435   PMID:7596436   PMID:7622047   PMID:7675451   PMID:7687867   PMID:7724599   PMID:8386825   PMID:8393164   PMID:8889548   PMID:9012504   PMID:9070927  
PMID:9247316   PMID:9778514   PMID:9794766   PMID:10323857   PMID:10349636   PMID:10395786   PMID:10428027   PMID:10499794   PMID:10685072   PMID:10700190   PMID:10887117   PMID:11042159  
PMID:11076861   PMID:11090062   PMID:11114734   PMID:11124112   PMID:11217851   PMID:11250889   PMID:11279005   PMID:11439183   PMID:11566878   PMID:11592985   PMID:11927535   PMID:12070340  
PMID:12093914   PMID:12112468   PMID:12361971   PMID:12393458   PMID:12477932   PMID:12614002   PMID:12819011   PMID:12867434   PMID:14634646   PMID:15072591   PMID:15073150   PMID:15322537  
PMID:15465483   PMID:15466359   PMID:15536152   PMID:15601855   PMID:15632376   PMID:15687262   PMID:15705793   PMID:15743836   PMID:15746084   PMID:15855638   PMID:15882861   PMID:16141072  
PMID:16141073   PMID:16462734   PMID:16470183   PMID:16602821   PMID:16624815   PMID:16675495   PMID:16678147   PMID:16778080   PMID:16849433   PMID:16877368   PMID:16944957   PMID:17210781  
PMID:17287396   PMID:17348685   PMID:17395646   PMID:17438136   PMID:17458866   PMID:17535974   PMID:17540175   PMID:17573777   PMID:17576138   PMID:17673674   PMID:17722983   PMID:17766486  
PMID:17948123   PMID:18097475   PMID:18338756   PMID:18367164   PMID:18411305   PMID:18508041   PMID:18519586   PMID:18570254   PMID:18594512   PMID:18951277   PMID:18973680   PMID:19005491  
PMID:19060331   PMID:19196316   PMID:19233265   PMID:19265261   PMID:19398761   PMID:19644017   PMID:19646499   PMID:19686679   PMID:19714652   PMID:19808642   PMID:19881219   PMID:19901262  
PMID:19903896   PMID:19910638   PMID:19938109   PMID:20042635   PMID:20065093   PMID:20110415   PMID:20110424   PMID:20179099   PMID:20223757   PMID:20224550   PMID:20231530   PMID:20336138  
PMID:20364082   PMID:20431062   PMID:20439428   PMID:20439995   PMID:20584329   PMID:20586849   PMID:20627076   PMID:20697430   PMID:20823159   PMID:20837699   PMID:20932899   PMID:20947685  
PMID:20978081   PMID:21166921   PMID:21267068   PMID:21273538   PMID:21282641   PMID:21481239   PMID:21498572   PMID:21508241   PMID:21515254   PMID:21677750   PMID:21704027   PMID:21705651  
PMID:21765212   PMID:21778431   PMID:21793101   PMID:21839079   PMID:21873635   PMID:21909098   PMID:22012621   PMID:22096492   PMID:22096573   PMID:22101523   PMID:22157817   PMID:22223733  
PMID:22306086   PMID:22426001   PMID:22430738   PMID:22474390   PMID:22538088   PMID:22615585   PMID:22665518   PMID:22723300   PMID:22761819   PMID:22797697   PMID:23056209   PMID:23219511  
PMID:23299940   PMID:23354168   PMID:23382219   PMID:23476047   PMID:23529931   PMID:23530147   PMID:23707896   PMID:24019535   PMID:24023956   PMID:24036251   PMID:24252749   PMID:24269955  
PMID:24357720   PMID:24361262   PMID:24469165   PMID:24550118   PMID:24567373   PMID:24590274   PMID:24656836   PMID:24690185   PMID:24700724   PMID:24723556   PMID:24733830   PMID:24917500  
PMID:24952961   PMID:25061878   PMID:25157650   PMID:25271254   PMID:25271623   PMID:25274728   PMID:25314967   PMID:25377552   PMID:25497097   PMID:25561555   PMID:25576926   PMID:25597700  
PMID:25606800   PMID:25637798   PMID:25643397   PMID:25704818   PMID:25737499   PMID:25772358   PMID:25800053   PMID:25958091   PMID:25992544   PMID:26002917   PMID:26027726   PMID:26038530  
PMID:26077718   PMID:26079578   PMID:26096340   PMID:26389677   PMID:26446156   PMID:26459520   PMID:26529256   PMID:26542011   PMID:26630461   PMID:26764350   PMID:26924464   PMID:26953188  
PMID:26984772   PMID:26993803   PMID:27066737   PMID:27251772   PMID:27313318   PMID:27329584   PMID:27464987   PMID:27507214   PMID:27525437   PMID:27699240   PMID:27789626   PMID:27810956  
PMID:27880905   PMID:27899284   PMID:27942023   PMID:27991863   PMID:28024299   PMID:28179430   PMID:28179432   PMID:28218908   PMID:28298294   PMID:28356442   PMID:28438786   PMID:28467822  
PMID:28526302   PMID:28658220   PMID:28663440   PMID:28849193   PMID:28924218   PMID:28935759   PMID:29035278   PMID:29141865   PMID:29169284   PMID:29361560   PMID:29550364   PMID:29569811  
PMID:29615616   PMID:29773646   PMID:29877568   PMID:29901792   PMID:30006544   PMID:30102256   PMID:30258227   PMID:30332639   PMID:30355615   PMID:30415924   PMID:30420641   PMID:30518756  
PMID:30582443   PMID:30582452   PMID:30586762   PMID:30601868   PMID:30618798   PMID:30621519   PMID:30635555   PMID:30718289   PMID:30783017   PMID:31083674   PMID:31112709   PMID:31138536  
PMID:31369756   PMID:31415243   PMID:31461654   PMID:31582413   PMID:31672914   PMID:31757960   PMID:31808745   PMID:31928974   PMID:31932457   PMID:32059772   PMID:32325033   PMID:32369453  
PMID:32405640   PMID:32513927   PMID:32518367   PMID:32544090   PMID:32673288   PMID:32903671   PMID:32941994   PMID:32951265   PMID:33060128   PMID:33253712   PMID:33298956   PMID:33299187  
PMID:33356387   PMID:33783987   PMID:33870127   PMID:33931446   PMID:34103491   PMID:34148274   PMID:34403369   PMID:34497373   PMID:34551997   PMID:34613809   PMID:34665379   PMID:35050301  
PMID:35222798   PMID:35728595   PMID:36046192   PMID:36051444   PMID:36064450   PMID:36196867   PMID:36216515   PMID:36362253   PMID:36395385   PMID:36450771   PMID:36688917   PMID:36697821  
PMID:37023750   PMID:37154714   PMID:37167063   PMID:37338522   PMID:37454290   PMID:37787089   PMID:37842094   PMID:38159569   PMID:38269589   PMID:38374152   PMID:38518198  


Genomics

Comparative Map Data
Flt4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391149,500,506 - 49,543,566 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1149,500,090 - 49,543,566 (+)EnsemblGRCm39 Ensembl
GRCm381149,609,679 - 49,652,739 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1149,609,263 - 49,652,739 (+)EnsemblGRCm38mm10GRCm38
MGSCv371149,423,181 - 49,466,241 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361149,453,150 - 49,495,652 (+)NCBIMGSCv36mm8
Celera1154,171,357 - 54,214,402 (+)NCBICelera
Cytogenetic Map11B1.2NCBI
cM Map1129.69NCBI
FLT4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385180,601,506 - 180,650,298 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5180,601,506 - 180,649,624 (-)EnsemblGRCh38hg38GRCh38
GRCh375180,028,506 - 180,076,600 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365179,961,112 - 180,009,206 (-)NCBINCBI36Build 36hg18NCBI36
Build 345179,962,147 - 180,009,171NCBI
Celera5175,651,089 - 175,699,841 (-)NCBICelera
Cytogenetic Map5q35.3NCBI
HuRef5174,752,484 - 174,782,989 (-)NCBIHuRef
CHM1_15179,460,942 - 179,509,118 (-)NCBICHM1_1
T2T-CHM13v2.05181,157,398 - 181,206,988 (-)NCBIT2T-CHM13v2.0
Flt4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81034,414,834 - 34,455,878 (+)NCBIGRCr8
mRatBN7.21033,913,725 - 33,954,770 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1033,913,608 - 33,954,770 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1038,589,263 - 38,630,365 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0107,127,669 - 7,168,775 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01033,582,919 - 33,624,021 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01035,078,782 - 35,120,296 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1035,078,726 - 35,121,599 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01034,850,707 - 34,892,141 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41035,071,002 - 35,112,006 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11035,072,050 - 35,113,055NCBI
Celera1033,270,535 - 33,311,432 (+)NCBICelera
Cytogenetic Map10q21NCBI
Flt4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955408107,056 - 140,056 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540898,995 - 137,922 (+)NCBIChiLan1.0ChiLan1.0
FLT4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24175,624,976 - 175,674,118 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15173,789,056 - 173,838,198 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05175,804,728 - 175,852,703 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15183,114,166 - 183,148,518 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5183,115,856 - 183,149,006 (-)Ensemblpanpan1.1panPan2
FLT4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1111,145,643 - 1,184,097 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl111,145,585 - 1,185,165 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha111,205,492 - 1,245,028 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0111,114,649 - 1,154,193 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1111,067,618 - 1,107,139 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0111,165,705 - 1,205,208 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0111,405,676 - 1,445,228 (+)NCBIUU_Cfam_GSD_1.0
Flt4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213119,026,753 - 119,071,689 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936739236,510 - 281,729 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936739240,572 - 281,925 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FLT4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl278,076,080 - 78,115,126 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1278,076,008 - 78,115,137 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2279,479,951 - 79,504,057 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FLT4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12382,328,257 - 82,373,785 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2382,328,258 - 82,357,044 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607513,749,531 - 13,795,003 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Flt4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473343,204,651 - 43,238,674 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473343,203,311 - 43,238,664 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Flt4
1052 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1474
Count of miRNA genes:627
Interacting mature miRNAs:787
Transcripts:ENSMUST00000020617, ENSMUST00000152253
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357844Si5lq5_mserum IGFBP-5 level QTL 5 (mouse)Not determined112816587362165976Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
12910804Pwbwq16_mpost-weaning body weight QTL 16 (mouse)112719805750636094Mouse
12910806Pwbwq15_mpost-weaning body weight QTL 15 (mouse)112719805750636094Mouse
12910801Pwbwq14_mpost-weaning body weight QTL 14 (mouse)112719805750636094Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
1301426Desp2_mdespair 2 (mouse)Not determined112870858162708700Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
12910817Pwgrq20_mpost-weaning growth rate QTL 20 (mouse)112719805750636094Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
12910818Ogrq5_moverall growth rate QTL 5 (mouse)112719805750636094Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111778196668500330Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
10053675Eae44b_mexperimental allergic encephalomyelitis susceptibility 44b (mouse)Not determined113995072854094448Mouse
4142475Ity2a_mimmunity to S. typhimurium 2a (mouse)Not determined113776858060402716Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
14746971Manh70_mmandible shape 70 (mouse)111990589053905890Mouse
13524848Ppiq7_mprepulse inhibition QTL 7 (mouse)112856914762569147Mouse
13452402Hipmt3_mhippocampal morphometry trait 3 (mouse)114797732550277325Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113557861669684987Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113210057766100694Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
1300938Bulb3_mbulb size 3 (mouse)Not determined111857861652578716Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
4141398Tgq22_mtriglyceride QTL 22 (mouse)Not determined2116340655163406Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113100820965008209Mouse
1300579Thypr1_mthymocyte proliferative response 1 (mouse)Not determined111928257753282715Mouse
12801459Leuf1_mleukocyte filtration 1 (mouse)111857861652578716Mouse
12801457Intmrm2_mintima/media ratio modifier 2 (mouse)111857861652578716Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
12801460Intim2_mintima modifier 2 (mouse)111857861652578716Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
1300713Vmbic10_mventral midbrain iron content 10 (mouse)Not determined114277262654081064Mouse
10044006Hbnr13_mHeligmosomoides bakeri nematode resistance 13 (mouse)Not determined112577262659772741Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse

Markers in Region
AI323512  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381149,652,469 - 49,652,580UniSTSGRCm38
MGSCv371149,465,971 - 49,466,082UniSTSGRCm37
Celera1154,214,132 - 54,214,243UniSTS
Cytogenetic Map11A5-B1UniSTS
Cytogenetic Map11B1.2UniSTS
Whitehead/MRC_RH11690.23UniSTS
Flt4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11A5-B1UniSTS
cM Map1125.0UniSTS
39.MMHAP15FRE12.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381149,645,579 - 49,645,747UniSTSGRCm38
MGSCv371149,459,081 - 49,459,249UniSTSGRCm37
Celera1154,207,242 - 54,207,410UniSTS
Cytogenetic Map11A5-B1UniSTS
Whitehead_YAC11 UniSTS
L07296  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381149,651,258 - 49,651,371UniSTSGRCm38
MGSCv371149,464,760 - 49,464,873UniSTSGRCm37
Celera1154,212,921 - 54,213,034UniSTS
Cytogenetic Map11B1.2UniSTS
Cytogenetic Map11A5-B1UniSTS
Whitehead/MRC_RH11688.0UniSTS
Flt4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11A5-B1UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000020617   ⟹   ENSMUSP00000020617
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1149,500,090 - 49,543,566 (+)Ensembl
GRCm38.p6 Ensembl1149,609,263 - 49,652,739 (+)Ensembl
RefSeq Acc Id: ENSMUST00000152253
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1149,500,090 - 49,519,768 (+)Ensembl
GRCm38.p6 Ensembl1149,609,263 - 49,628,941 (+)Ensembl
RefSeq Acc Id: NM_008029   ⟹   NP_032055
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391149,500,506 - 49,543,566 (+)NCBI
GRCm381149,609,679 - 49,652,739 (+)ENTREZGENE
MGSCv371149,423,181 - 49,466,241 (+)RGD
Celera1154,171,357 - 54,214,402 (+)RGD
cM Map11 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_032055 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40077 (Get FASTA)   NCBI Sequence Viewer  
  AAI38347 (Get FASTA)   NCBI Sequence Viewer  
  AAI38349 (Get FASTA)   NCBI Sequence Viewer  
  AAL05952 (Get FASTA)   NCBI Sequence Viewer  
  EDL33745 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000020617
  ENSMUSP00000020617.3
GenBank Protein P35917 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_032055   ⟸   NM_008029
- Peptide Label: precursor
- UniProtKB: P35917 (UniProtKB/Swiss-Prot),   Q5SU94 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000020617   ⟸   ENSMUST00000020617
Protein Domains
Ig-like   Ig-like C2-type   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35917-F1-model_v2 AlphaFold P35917 1-1363 view protein structure

Promoters
RGD ID:8674476
Promoter ID:EPDNEW_M15268
Type:multiple initiation site
Name:Flt4_1
Description:Mus musculus FMS-like tyrosine kinase 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381149,609,715 - 49,609,775EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95561 AgrOrtholog
Ensembl Genes ENSMUSG00000020357 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000020617 ENTREZGENE
  ENSMUST00000020617.3 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_rcpt_3_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VEGFR-2_TMD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14257 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:95561 ENTREZGENE
NCBI Gene 14257 ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VEGFR-1-like_Ig-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VEGFR-2_TMD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Flt4 PhenoGen
PIRSF TyrPK_CSF1-R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS VEGFRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VEGFRECEPTR3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_III UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IGc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt P35917 ENTREZGENE
  Q5SU94 ENTREZGENE, UniProtKB/TrEMBL
  VGFR3_MOUSE UniProtKB/Swiss-Prot